NO130041B - - Google Patents
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- Publication number
- NO130041B NO130041B NO267469A NO267469A NO130041B NO 130041 B NO130041 B NO 130041B NO 267469 A NO267469 A NO 267469A NO 267469 A NO267469 A NO 267469A NO 130041 B NO130041 B NO 130041B
- Authority
- NO
- Norway
- Prior art keywords
- weight
- water
- soluble
- phosphate
- phosphates
- Prior art date
Links
- 239000000203 mixture Substances 0.000 claims description 20
- 229910019142 PO4 Inorganic materials 0.000 claims description 15
- 150000002222 fluorine compounds Chemical class 0.000 claims description 15
- 235000021317 phosphate Nutrition 0.000 claims description 15
- 239000003795 chemical substances by application Substances 0.000 claims description 13
- 239000003513 alkali Substances 0.000 claims description 11
- 102000004190 Enzymes Human genes 0.000 claims description 10
- 108090000790 Enzymes Proteins 0.000 claims description 10
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims description 10
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 8
- 229910052816 inorganic phosphate Inorganic materials 0.000 claims description 8
- AVPCPPOOQICIRJ-UHFFFAOYSA-L sodium glycerol 2-phosphate Chemical compound [Na+].[Na+].OCC(CO)OP([O-])([O-])=O AVPCPPOOQICIRJ-UHFFFAOYSA-L 0.000 claims description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 5
- 239000010452 phosphate Substances 0.000 claims description 5
- 239000000654 additive Substances 0.000 claims description 4
- 229910000397 disodium phosphate Inorganic materials 0.000 claims description 4
- 235000019800 disodium phosphate Nutrition 0.000 claims description 4
- 229940074371 monofluorophosphate Drugs 0.000 claims description 4
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 claims description 4
- 230000000395 remineralizing effect Effects 0.000 claims description 4
- 239000012736 aqueous medium Substances 0.000 claims description 3
- 239000004566 building material Substances 0.000 claims description 3
- 150000005846 sugar alcohols Polymers 0.000 claims description 2
- 239000000606 toothpaste Substances 0.000 description 14
- 229940034610 toothpaste Drugs 0.000 description 12
- 241001465754 Metazoa Species 0.000 description 10
- 208000002925 dental caries Diseases 0.000 description 9
- 229940088598 enzyme Drugs 0.000 description 9
- 238000004140 cleaning Methods 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical class F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 4
- -1 glucose-1-fpsfat Chemical compound 0.000 description 4
- 235000019796 monopotassium phosphate Nutrition 0.000 description 4
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 4
- 239000002324 mouth wash Substances 0.000 description 4
- 229940051866 mouthwash Drugs 0.000 description 4
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 4
- 108010065511 Amylases Proteins 0.000 description 3
- 102000013142 Amylases Human genes 0.000 description 3
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 3
- 239000004367 Lipase Substances 0.000 description 3
- 102000004882 Lipase Human genes 0.000 description 3
- 108090001060 Lipase Proteins 0.000 description 3
- 239000004365 Protease Substances 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- 235000019418 amylase Nutrition 0.000 description 3
- 210000003298 dental enamel Anatomy 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 229940091249 fluoride supplement Drugs 0.000 description 3
- 235000019421 lipase Nutrition 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 2
- 244000063299 Bacillus subtilis Species 0.000 description 2
- 235000014469 Bacillus subtilis Nutrition 0.000 description 2
- 108010001682 Dextranase Proteins 0.000 description 2
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 108010019160 Pancreatin Proteins 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 229940025131 amylases Drugs 0.000 description 2
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- 239000000551 dentifrice Substances 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 229940079919 digestives enzyme preparation Drugs 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 2
- PQXKHYXIUOZZFA-UHFFFAOYSA-M lithium fluoride Chemical compound [Li+].[F-] PQXKHYXIUOZZFA-UHFFFAOYSA-M 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 125000005341 metaphosphate group Chemical group 0.000 description 2
- 229940055695 pancreatin Drugs 0.000 description 2
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- BHHYHSUAOQUXJK-UHFFFAOYSA-L zinc fluoride Chemical compound F[Zn]F BHHYHSUAOQUXJK-UHFFFAOYSA-L 0.000 description 2
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 description 1
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 1
- RMSOEGBYNWXXBG-UHFFFAOYSA-N 1-chloronaphthalen-2-ol Chemical compound C1=CC=CC2=C(Cl)C(O)=CC=C21 RMSOEGBYNWXXBG-UHFFFAOYSA-N 0.000 description 1
- 229940090248 4-hydroxybenzoic acid Drugs 0.000 description 1
- DDFHBQSCUXNBSA-UHFFFAOYSA-N 5-(5-carboxythiophen-2-yl)thiophene-2-carboxylic acid Chemical compound S1C(C(=O)O)=CC=C1C1=CC=C(C(O)=O)S1 DDFHBQSCUXNBSA-UHFFFAOYSA-N 0.000 description 1
- 241000223600 Alternaria Species 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 241000228212 Aspergillus Species 0.000 description 1
- 241000980809 Aspergillus aureus Species 0.000 description 1
- 241001513093 Aspergillus awamori Species 0.000 description 1
- 241000228197 Aspergillus flavus Species 0.000 description 1
- 241000178168 Aspergillus inuii Species 0.000 description 1
- 241000228245 Aspergillus niger Species 0.000 description 1
- 240000006439 Aspergillus oryzae Species 0.000 description 1
- 241000134719 Aspergillus tamarii Species 0.000 description 1
- 241001507822 Aspergillus terricola Species 0.000 description 1
- 241001112078 Aspergillus usamii Species 0.000 description 1
- 241000228260 Aspergillus wentii Species 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
- 108010004032 Bromelains Proteins 0.000 description 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 1
- 108090000317 Chymotrypsin Proteins 0.000 description 1
- 229910021594 Copper(II) fluoride Inorganic materials 0.000 description 1
- GSXOAOHZAIYLCY-UHFFFAOYSA-N D-F6P Natural products OCC(=O)C(O)C(O)C(O)COP(O)(O)=O GSXOAOHZAIYLCY-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- NBSCHQHZLSJFNQ-GASJEMHNSA-N D-Glucose 6-phosphate Chemical compound OC1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O NBSCHQHZLSJFNQ-GASJEMHNSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- GACTWZZMVMUKNG-UHFFFAOYSA-N D-sorbitol phosphate Natural products OCC(O)C(O)C(O)C(O)COP(O)(O)=O GACTWZZMVMUKNG-UHFFFAOYSA-N 0.000 description 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
- 241001409019 Eulampis Species 0.000 description 1
- 108090000270 Ficain Proteins 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- VFRROHXSMXFLSN-UHFFFAOYSA-N Glc6P Natural products OP(=O)(O)OCC(O)C(O)C(O)C(O)C=O VFRROHXSMXFLSN-UHFFFAOYSA-N 0.000 description 1
- 241000896533 Gliocladium Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- 229920000877 Melamine resin Polymers 0.000 description 1
- 241001363490 Monilia Species 0.000 description 1
- 241000235395 Mucor Species 0.000 description 1
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 1
- 241000221960 Neurospora Species 0.000 description 1
- 108090000526 Papain Proteins 0.000 description 1
- 241000228143 Penicillium Species 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 229920000388 Polyphosphate Polymers 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 241000235527 Rhizopus Species 0.000 description 1
- 235000004443 Ricinus communis Nutrition 0.000 description 1
- 240000000528 Ricinus communis Species 0.000 description 1
- 241000235070 Saccharomyces Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 241000187747 Streptomyces Species 0.000 description 1
- 241001136494 Talaromyces funiculosus Species 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- 241000223259 Trichoderma Species 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 229920001807 Urea-formaldehyde Polymers 0.000 description 1
- JZJNHPJBZWEHPD-UHFFFAOYSA-N [F].[Na] Chemical compound [F].[Na] JZJNHPJBZWEHPD-UHFFFAOYSA-N 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 102000004139 alpha-Amylases Human genes 0.000 description 1
- 108090000637 alpha-Amylases Proteins 0.000 description 1
- 229940024171 alpha-amylase Drugs 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 229940024548 aluminum oxide Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- LFVGISIMTYGQHF-UHFFFAOYSA-N ammonium dihydrogen phosphate Chemical compound [NH4+].OP(O)([O-])=O LFVGISIMTYGQHF-UHFFFAOYSA-N 0.000 description 1
- ZRIUUUJAJJNDSS-UHFFFAOYSA-N ammonium phosphates Chemical compound [NH4+].[NH4+].[NH4+].[O-]P([O-])([O-])=O ZRIUUUJAJJNDSS-UHFFFAOYSA-N 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 230000003625 amylolytic effect Effects 0.000 description 1
- 230000000675 anti-caries Effects 0.000 description 1
- 235000019568 aromas Nutrition 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- BGWGXPAPYGQALX-ARQDHWQXSA-N beta-D-fructofuranose 6-phosphate Chemical compound OC[C@@]1(O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O BGWGXPAPYGQALX-ARQDHWQXSA-N 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 235000019835 bromelain Nutrition 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
- 229940043256 calcium pyrophosphate Drugs 0.000 description 1
- 108010089934 carbohydrase Proteins 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 229960002376 chymotrypsin Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000007859 condensation product Substances 0.000 description 1
- GWFAVIIMQDUCRA-UHFFFAOYSA-L copper(ii) fluoride Chemical compound [F-].[F-].[Cu+2] GWFAVIIMQDUCRA-UHFFFAOYSA-L 0.000 description 1
- 238000005115 demineralization Methods 0.000 description 1
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 1
- SAEOCANGOMBQSP-UHFFFAOYSA-N diazanium;fluoro-dioxido-oxo-$l^{5}-phosphane Chemical compound [NH4+].[NH4+].[O-]P([O-])(F)=O SAEOCANGOMBQSP-UHFFFAOYSA-N 0.000 description 1
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
- 229940038472 dicalcium phosphate Drugs 0.000 description 1
- 150000004683 dihydrates Chemical class 0.000 description 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
- 235000019797 dipotassium phosphate Nutrition 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 235000014103 egg white Nutrition 0.000 description 1
- 210000000969 egg white Anatomy 0.000 description 1
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- 239000003925 fat Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 235000019836 ficin Nutrition 0.000 description 1
- POTUGHMKJGOKRI-UHFFFAOYSA-N ficin Chemical compound FI=CI=N POTUGHMKJGOKRI-UHFFFAOYSA-N 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
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- 239000010794 food waste Substances 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 229910000040 hydrogen fluoride Inorganic materials 0.000 description 1
- SHXXPRJOPFJRHA-UHFFFAOYSA-K iron(iii) fluoride Chemical compound F[Fe](F)F SHXXPRJOPFJRHA-UHFFFAOYSA-K 0.000 description 1
- 229940045996 isethionic acid Drugs 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
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- 229910052744 lithium Inorganic materials 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- 235000019960 monoglycerides of fatty acid Nutrition 0.000 description 1
- DBJLJFTWODWSOF-UHFFFAOYSA-L nickel(ii) fluoride Chemical compound F[Ni]F DBJLJFTWODWSOF-UHFFFAOYSA-L 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 150000004812 organic fluorine compounds Chemical class 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- BHZSLLSDZFAPFH-UHFFFAOYSA-L palladium(2+);difluoride Chemical compound F[Pd]F BHZSLLSDZFAPFH-UHFFFAOYSA-L 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
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- 229920002223 polystyrene Polymers 0.000 description 1
- 229920000166 polytrimethylene carbonate Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
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- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 235000003270 potassium fluoride Nutrition 0.000 description 1
- 239000011698 potassium fluoride Substances 0.000 description 1
- KNBZLZHMHWFBSE-UHFFFAOYSA-M potassium;2-aminoacetic acid;fluoride Chemical compound [F-].[K+].NCC(O)=O KNBZLZHMHWFBSE-UHFFFAOYSA-M 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 229910052814 silicon oxide Inorganic materials 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- BFDWBSRJQZPEEB-UHFFFAOYSA-L sodium fluorophosphate Chemical group [Na+].[Na+].[O-]P([O-])(F)=O BFDWBSRJQZPEEB-UHFFFAOYSA-L 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- GACTWZZMVMUKNG-ZXXMMSQZSA-N sorbitol 6-phosphate Chemical compound OC[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)COP(O)(O)=O GACTWZZMVMUKNG-ZXXMMSQZSA-N 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- YUOWTJMRMWQJDA-UHFFFAOYSA-J tin(iv) fluoride Chemical compound [F-].[F-].[F-].[F-].[Sn+4] YUOWTJMRMWQJDA-UHFFFAOYSA-J 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 229960001322 trypsin Drugs 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 229910052845 zircon Inorganic materials 0.000 description 1
- GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Description
Den kariesbeskyttendé virkning av de forskjellige fluorforbindelser har lenge vært kjent og har i det vesentlige vært ube-stridt. Denne erkjennelse har vært utnyttet i terapeutisk bye-med ved at man har latt forskjellige fluorforbindelser inngå i The caries-protective effect of the various fluorine compounds has long been known and has essentially been undisputed. This realization has been utilized in therapeutic bye-med by including different fluorine compounds
tannpleiemidler, f.eks. tannpasta, munnvann, tannpulver eller tannrerisetabletter. Det er også kjent at kariesrisikoen har dental care products, e.g. toothpaste, mouthwash, tooth powder or teeth whitening tablets. It is also known that the caries risk has
forbindelse med deminéraliseringsprosesser i tannemaljen. Det har vist seg at en remineralisering av tannemaljen dg dermed en connection with demineralization processes in the tooth enamel. It has been shown that a remineralization of the tooth enamel dg thus a
bedre beskyttelse mot karies" kan oppnåes ved tannpleie med tannpleiemidler som inneholder en kombinasjon av vannopploselige anorganiske fosfater, vannopploselige organiske fosfater'og better protection against caries" can be achieved by dental care with dental care agents containing a combination of water-soluble inorganic phosphates, water-soluble organic phosphates' and
vannopploselige fluorforbindelser og i et vandig medium har en pH-yerdi mellom 4,5 og 6,5. water-soluble fluorine compounds and in an aqueous medium have a pH between 4.5 and 6.5.
Tannpleiemidler i forbindelse med oppfinnelsen er tannpasta, munnvann, tannpulver, tyggegummi og tannrensetabletter. Tooth care products in connection with the invention are toothpaste, mouthwash, tooth powder, chewing gum and teeth cleaning tablets.
Tannpleiemiddel ifolge nærværende oppfinnelse med remineraliserende egenskaper .på basis av'vanlige oppbygnings- og .tilsetningsstoffer, som inneholder en blanding av organiske fosfater, uorganiske fosfater og fluorforbindelser, fortrinnsvis et alkalimonofluorfosfat, såvel som eventuelt enzymer, karakteriseres ved at det inneholder 0,5 til 15 vekts% vannopploselige uorganiske fosfater , .0,5 til 10 vekts% vannopploselige organiske fos-fa£er som sukkérfosfat og/eller fosfat av flerverdige alkoholer, og 0,1 til 10 vek'ts% vannopploselige f luorf orbindelser og har en pH-verdi på 4,5 til 6,5 i vandig medium. Som vannopploselige anorganiske fosfater kan det f.eks. benyttes monokaliumdi-hydrogenortofosfat, dikaliumhydrogenortofosfat, trikaliumorto- ' fosfat, ammoniumdihydrogenortofosfat, diammoniumhydrogenortofos-fat, triammoniumortofosfat, natriumdihydrogenortofosfat, dinatriumhydrogenortofosfat, trinatriumortofosfat, vannopploselige alkalimetafosfater, vannopploselige alkalipolyfosfater eller blandinger av disse fosfater i valgfrie blandingsforhold. En blanding av kaliumdihydrogenortofosfat og dinatriumhydrogén-ortofosfat i forholdet 1:1 har vist seg å være spesielt gunstig. Tooth care agent according to the present invention with remineralizing properties, based on common building materials and additives, which contains a mixture of organic phosphates, inorganic phosphates and fluorine compounds, preferably an alkali monofluorophosphate, as well as possibly enzymes, is characterized by containing 0.5 to 15% by weight of water-soluble inorganic phosphates, 0.5 to 10% by weight of water-soluble organic phosphates such as sugar phosphate and/or phosphate of polyhydric alcohols, and 0.1 to 10% by weight of water-soluble fluorine compounds and has a pH -value of 4.5 to 6.5 in aqueous medium. As water-soluble inorganic phosphates, it can e.g. monopotassium dihydrogen orthophosphate, dipotassium hydrogen orthophosphate, tripotassium orthophosphate, ammonium dihydrogen orthophosphate, diammonium hydrogen orthophosphate, triammonium orthophosphate, sodium dihydrogen orthophosphate, disodium hydrogen orthophosphate, trisodium orthophosphate, water-soluble alkali metaphosphates, water-soluble alkali polyphosphates or mixtures of these phosphates in optional mixing ratios are used. A mixture of potassium dihydrogen orthophosphate and disodium hydrogen orthophosphate in a 1:1 ratio has proven to be particularly beneficial.
Som vannopploselige organiske fosfater benyttes f.eks. mdno- As water-soluble organic phosphates, e.g. mdno-
og dinatriumglycerofosfat, fruktose-6-fosfat, sorbit-6-fosfat, glukose-l-fpsfat, glukose-6-fosfat, deres vannopploselige salter eller blandinger av disse fosfater. Som foretrukket orga-nisk vannopploselig fosfat benyttes dinatriumglycerofosfat. and disodium glycerophosphate, fructose-6-phosphate, sorbitol-6-phosphate, glucose-1-fpsfat, glucose-6-phosphate, their water-soluble salts or mixtures of these phosphates. The preferred organic water-soluble phosphate is disodium glycerophosphate.
Som vannopploselige fluorforbindelser kan det f.eks. benyttes alkalifluorider, som litiumfluorid, kaliumfluorid, natrium-fluorid, ammoniumfluorid, samt sinkfluorid, indiumfluorid, tinnfluorid, zirkonfluorid, :jernfluorid, solvfluoridj kobber-fluorid, nikkelfluorid, palladiumfluorid, komple.ksbundne f luorforbindelser , som alkalif luorzirkOnater , tinnf luor-.,. zirkonat, . f luorsilikater,. f luor borat er ,. f luorstanniter eller alkalifluorfosfater. Som eksempler på vannopplose- As water-soluble fluorine compounds, it can e.g. Alkali fluorides are used, such as lithium fluoride, potassium fluoride, sodium fluoride, ammonium fluoride, as well as zinc fluoride, indium fluoride, stannous fluoride, zircon fluoride, iron fluoride, solv fluoride, copper fluoride, nickel fluoride, palladium fluoride, complex fluorine compounds, such as alkali fluoride zirconate, tin fluoride, . zirconate, . f fluorosilicates,. f luor borate is ,. f fluorstannites or alkali fluorophosphates. As examples of water-dissolving
lige organiske fluorforbindelser kan nevnes amin- equal organic fluorine compounds can be mentioned amine-
hydrofluorider, alkanolaminh<y>drofluorider, kvaternære ammonium-fluorider, vannopploselige addisjonsforbindelser av aminosyrer og fluorhydrogen eller fluorider, som betainhydrofluorid eller glycinkaliumfluorid. Det kan også benyttes blandinger av slike fluorforbindelser. Alkalimonofluorfosfater, som litium-, na-trium-, kalium- eller.ammoniummonofluorfosfat, har vist seg å være særdeles velegnede vannopploselige fluorforbindelser i kombinasjonen ifolge oppfinnelsen. hydrofluorides, alkanolamine hydrofluorides, quaternary ammonium fluorides, water-soluble addition compounds of amino acids and hydrogen fluoride or fluorides, such as betaine hydrofluoride or glycine potassium fluoride. Mixtures of such fluorine compounds can also be used. Alkali monofluorophosphates, such as lithium, sodium, potassium or ammonium monofluorophosphate, have proven to be particularly suitable water-soluble fluorine compounds in the combination according to the invention.
En foretrukket utforelsesform av oppfinnelsen som har vist en optimal reduksjon av kariesangrep, består av et tannpleiemiddel, som foruten de vanlige tilsetnings- og fyllstoffer inneholder 3,0 til 10,0 vekt-% av en blanding av monokaliumdihydro-genortofosfat og dinatriumhydrogenortofosfat i forholdet .1:1,. 1,0 til 5,0 vekt-% dinatriumglycerofosfat og 0,1'5 til 5,0 vekt-% av et alkalimonofluorfosfat. A preferred embodiment of the invention which has shown an optimal reduction of caries attack consists of a dental care agent, which, in addition to the usual additives and fillers, contains 3.0 to 10.0% by weight of a mixture of monopotassium dihydrogenorthophosphate and disodium hydrogenorthophosphate in the ratio . 1:1,. 1.0 to 5.0% by weight disodium glycerophosphate and 0.1.5 to 5.0% by weight of an alkali monofluorophosphate.
Den remineraliserende virkning av vannopploselige anorganiske og organiske fosfater, på tannemaljen er i og for seg kjent. Det er også blitt foreslått tannpleiemidler, som tannpasta og munnvann, som inneholder en kombinasjon av vannopploselige anorganiske fosfater og vannopploselige fluorforbindelser, og som er foreslått brukt som kariesforebyggende midler. Den utmerkede antikaries-virkning vedTkombinasjonen ifolge oppfinnelsen av. vannopploselige anorganiske fosfater, vannopploselige organiske fosfater og vannopploselige f luorf orbindelser og dennes o.yerle^ genhet i forhold til kombinasjoner som svarer til teknikkens, stand, vil fremgå av nedenstående omtalte dyreforsdk. The remineralizing effect of water-soluble inorganic and organic phosphates on tooth enamel is known per se. Dental care agents, such as toothpaste and mouthwash, have also been proposed, which contain a combination of water-soluble inorganic phosphates and water-soluble fluorine compounds, and which have been proposed for use as caries preventive agents. The excellent anti-caries effect of the T combination according to the invention of. water-soluble inorganic phosphates, water-soluble organic phosphates and water-soluble fluorine compounds and their superiority in relation to combinations that correspond to the state of the art, will be apparent from the animal research mentioned below.
Forsoksberetninq Trial report
For det omtalte, 21 dogns dyreforsdk ble det brukt 14 dager gamle Osborne-Mendél-rotter, som ble foret med karibgen kost (Stephan-kost 580). Det ble brukt 20 dyr pr. gruppe. Av dyrene dode\bare ett dyr for forsbkets slutt i placébo-gruppén (gruppe 2). Dyrene i de enkelte grupper fikk sine tenner pusset to gan-ger om dagen med en spesialtannbbrste som i storrelse vår til-passet rottegapet, og med tannpastaer av- fblgendé sammensetning: For the mentioned, 21-day animal study, 14-day-old Osborne-Mendél rats were used, which were fed Carib diet (Stephan diet 580). 20 animals were used per group. Of the animals, only one animal died before the end of the experiment in the placebo group (group 2). The animals in the individual groups had their teeth brushed twice a day with a special toothbrush which, in size, was adapted to the rat's gap, and with toothpastes of the following composition:
Gruppe 1: Ubehandlet kontrollgruppe Group 1: Untreated control group
Gruppe 2: Grunnresept Group 2: Basic recipe
Gruppe 3: Grunnresept + blanding av Group 3: Basic recipe + mixture of
3,75 vekt-% dinatriumhydrogenfosfat x 2H»0 og 2,85 vekt-% kaliumdihydrogenfosfat 3.75% by weight disodium hydrogen phosphate x 2H»0 and 2.85% by weight potassium dihydrogen phosphate
Gruppe 4: Grunnresept + 2,lo vekt-% dinatriumglycerofosf at x 5 H20 Gruppe 5: Grunnresept + 0,75 vekt-% natriummonofluorfosfat Gruppe 6: Grunnresept + blanding av Group 4: Basic recipe + 2.lo weight-% disodium glycerophosphat at x 5 H20 Group 5: Basic recipe + 0.75 weight-% sodium monofluorophosphate Group 6: Basic recipe + mixture of
3,75 vekt-% dinatriumhydrogenfosfat x 21^0, 2,85 vekt-% kaliumdihydrogenfosfat.og 2,lo vekt-% dinatriumglycerofosfat x 5H20 Gruppe 7: Grunnresept + blanding' av 3,75 vekt-% dinatriumhydrogenfosfat. x^I^O 2,85 vekt-% kaliumdihydrogenfosfat og 3.75 wt-% disodium hydrogen phosphate x 21^0, 2.85 wt-% potassium dihydrogen phosphate.and 2.lo wt-% disodium glycerophosphate x 5H20 Group 7: Basic recipe + mixture' of 3.75 wt-% disodium hydrogen phosphate. x^I^O 2.85% by weight potassium dihydrogen phosphate and
0,'75 vekt-% natriummonof luorf osf at Gruppe 8: Grunnresept + blanding av 0.75% by weight of sodium monofluorine, etc. Group 8: Basic recipe + mixture of
2, lo vekt-% dinatriumglycerofosf at x 51^0 0,75 vekt-% natriummonofluorfosfat 2, lo weight-% disodium glycerophosphat at x 51^0 0.75 weight-% sodium monofluorophosphate
Gruppe 9: Grunnresept + blanding av Group 9: Basic recipe + mixture of
3,75 vekt-% dinatriumhydrogenfosfat x 21^0 3.75% by weight disodium hydrogen phosphate x 21^0
2,85 vekt-% kaliumdihydrogenfosfat 2.85% by weight potassium dihydrogen phosphate
2,lo vekt-% dinatriumglycerofosfat x 51^0 o,75 vekt-% natriummonofluorfosfat. 2.lo weight-% disodium glycerophosphate x 51^0 o.75 weight-% sodium monofluorophosphate.
Grunnresepten har folgende sammensetning: The basic recipe has the following composition:
Vektutligningen ved tilsetning av.de forskjellige aktive stoffer ble oppnådd ved forandring av vanngehalten. The weight equalization by adding the different active substances was achieved by changing the water content.
Etter at forsokene var avsluttet,: ble dyrene drept og deres tenner undersokt. De karieslesjoner. som ble observert på dyrenes tenner ble gradert A, B, C. og D etter deres ■. styrke. Su er summen av lesjonsgradene, x er den utregnede gjennomsnittsverdi.. After the experiments were finished, the animals were killed and their teeth examined. The carious lesions. which were observed on the animals' teeth were graded A, B, C. and D according to their ■. strength. Su is the sum of the lesion degrees, x is the calculated average value.
Av de anforte dyreforsok fremgår det således én entydig over-legen kariesprotektiv virkningihos den ifolge oppfinnelsen fo-reslåtte kombinasjon av aktive stoffer, sammenlignet med de kjente sammensetninger. From the animal experiments cited, there is thus one clearly superior caries protective effect in the combination of active substances proposed according to the invention, compared to the known compositions.
Virkningen av disse tannpleiemidler, spesielt deres renseevne og dermed deres kariesprofylaktiske effekt, kan okes ytterligere hvis man i tillegg tilsetter enzymer til disse midler. Enzymene skal tjene til å bryte ned matrester som måtte være igjen i tann- og munnområdet, og dermed sikre en fullstendig rengjoring. Spesielt egnet er proteolytiske enzymer, som spalter eggehvite, skjont det er også hensiktsmessig å bruke carbohydraser, spesielt amylaser, som bryter ned kullhydrater, og lipaser, som bryter ned fettstoffer, i tannpleiemidlene ifolge oppfinnelsen. Særdeles hensiktsmessig vil det således være å benytte blandinger av disse enzymer, f.eks. slik de foreligger i pankreatin. The effect of these dental care agents, especially their cleaning ability and thus their caries-prophylactic effect, can be increased further if enzymes are additionally added to these agents. The enzymes will serve to break down food residues that may be left in the teeth and mouth area, thus ensuring a complete cleaning. Proteolytic enzymes, which break down egg whites, are particularly suitable, although it is also appropriate to use carbohydrases, especially amylases, which break down carbohydrates, and lipases, which break down fats, in the dental care products according to the invention. It would thus be particularly appropriate to use mixtures of these enzymes, e.g. as they exist in pancreatin.
Enzymer med proteolytisk, amylolytisk og/éller lipolytisk akti-vitet, som kan benyttes innenfor'rammen for foreliggende oppfinnelse, ér i det "vesentlige alle hittil kjente enzymer, uansett om deres anvendelse i tannpleiemidler er ny eller i og for seg kjent, som f .eks,, enzymer av animalsk eller vegetabilsk opprin-nelse. Til disse horer foruten det ovennevnte pankreatin også pepsin, trypsin, chymotrypsih,. amylase og lipase av pankreas-kjertler samt de vegetabilske enzymer papain,.; bromelin,", f icin, Enzymes with proteolytic, amylolytic and/or lipolytic activity, which can be used within the framework of the present invention, are essentially all enzymes known to date, regardless of whether their use in dental care products is new or known per se, such as .eg, enzymes of animal or vegetable origin. In addition to the above-mentioned pancreatin, these also include pepsin, trypsin, chymotrypsin, amylase and lipase of pancreatic glands as well as the vegetable enzymes papain, bromelain, ficin,
a-amylase av malt og lipase av ricinusbonner. α-amylase from malt and lipase from castor beans.
Videre har "enzympreparater"som kan utvinnes ved dyrking av mikroorganismer som muggsopp eller bakterier, vist seg.hensikts-messige i tannpleiemidler ifolge foreliggende oppfinnelse. Egnede muggsopper er f.eks. muggsopper av arten Candida, Saccharo-myces, Aspergillus, som A.niger, A.oryzae, A. flavus, A.usamii, A.inuii, A.awamori, A.aureus, A.tamarii, A.wentii og A.terri-cola, videre sopp av arten Alternaria, Rhizopus, Mucor, Monilia, Gliocladium, Neurospora, Trichoderma eller Penicillium. Som en-zymdannende bakteriestammer er f.eks. artene Streptomyces og Bacillus, som B.subtilis, B.mesentericus, B.hydrolyticus, B.mq-riguchiensis og B.diastaticus, egnet for fremstilling av enzym-preparater som kan benyttes i tannpleiemidlene ifolge oppfinnelsen. Proteaser og/eller amylaser av Bacillus subtilis er spesielt foretrukket på grunn.av sin-utmerkede stabilitet i nærvær av vann. Furthermore, "enzyme preparations" which can be extracted by cultivating microorganisms such as molds or bacteria have proven to be appropriate in dental care products according to the present invention. Suitable molds are e.g. molds of the species Candida, Saccharo-myces, Aspergillus, such as A.niger, A.oryzae, A.flavus, A.usamii, A.inuii, A.awamori, A.aureus, A.tamarii, A.wentii and A. terri-cola, further fungi of the species Alternaria, Rhizopus, Mucor, Monilia, Gliocladium, Neurospora, Trichoderma or Penicillium. As enzyme-producing bacterial strains are e.g. the species Streptomyces and Bacillus, such as B. subtilis, B. mesentericus, B. hydrolyticus, B. mq-riguchiensis and B. diastaticus, suitable for the production of enzyme preparations which can be used in the dental care products according to the invention. Proteases and/or amylases of Bacillus subtilis are particularly preferred because of their excellent stability in the presence of water.
Hensiktsmessig for okning-av den kariesprofylaktiske virkning . -.a^tannpleiemidlene ifolge oppfinnelsen med remineraliserende egenskaper er også tilsetning av dextranaser, .sorti i og for seg : er kjent -i tannpleiemidler, spesielt dextranaser av Penicillium funiculosum. Suitable for increasing the caries-prophylactic effect. - The dental care agents according to the invention with remineralizing properties are also the addition of dextranases, various in and of themselves: are known - in dental care agents, especially dextranases from Penicillium funiculosum.
Enzymene foreligger i tannpleiemidlene fortrinnsvis i mengder, på o,o5 til lo,o vekt-% av den totale komposisjon.,. The enzymes are present in the dentifrices preferably in amounts of 0.05 to 10.0% by weight of the total composition.
Tannpleiemidlene ifolge foreliggende oppfinnelse inneholder de.. vanlige oppbygnings- og tilsetningsstoffer. Ved fremstilling av tannpasta, tannpulver og tannrensetabletter kan det som pole-ringsmidler brukes alle stoffer som hittil er foreslått for det-te formål, som dikalsiumfosfat og/eller, dettes dihydrat, trikal-siumfosfat, kalsiumpyrofosfat, aluminiumoksyd, silisiumoksyd, kaolin, vannuopploselige: alkalimetafosfater', samt pulveriserte kunststoffer,, som polyvinylklorid, polyamider, polymetylmeta-crylat, polystyrol, . fenol-formal.dehyd-harpiksér, .-melamin-formaldehyd-harpikser, urinstoff-formaldehyd-harpikser.., epoksyharpik-ser, polykarbonater o.l.. Det kan. også brukes blandinger av dis- The dentifrices according to the present invention contain the usual building materials and additives. In the production of toothpaste, tooth powder and tooth cleaning tablets, all substances that have been proposed for that purpose up to now can be used as polishing agents, such as dicalcium phosphate and/or its dihydrate, tricalcium phosphate, calcium pyrophosphate, aluminum oxide, silicon oxide, kaolin, water insoluble: alkali metaphosphates', as well as powdered plastics, such as polyvinyl chloride, polyamides, polymethyl methacrylate, polystyrene, . phenol-formaldehyde resins, .-melamine-formaldehyde resins, urea-formaldehyde resins.., epoxy resins, polycarbonates etc.. It can. mixtures of dis-
se stoffer. see substances.
Som binde- og tykningsmidler i tannpasta brukes f.eks. stivelse, tragant, alginater, pektin, cellulosederivater, polyakrylsyre og dennes salter, polyvinylpyrrolidon, samt forskjellige gummer (Gummen). As binding and thickening agents in toothpaste, e.g. starch, tragacanth, alginates, pectin, cellulose derivatives, polyacrylic acid and its salts, polyvinylpyrrolidone, as well as various gums (Gummen).
Egnede fuktighetsbevarende midler er glycerin, sorbit, 1,3-propandiol og/eller 1,4 butandiol. Suitable humectants are glycerin, sorbitol, 1,3-propanediol and/or 1,4 butanediol.
Foruten de vanlige smaks- og aromastoffér kan tannpleiemidlene inneholdé konserveringsmidler som p-hydroksy-bensoesyreester -,- In addition to the usual flavors and aromas, the toothpastes may contain preservatives such as p-hydroxy-benzoic acid ester -,-
/ i. samt eventuelt otiske lysgjoringsmidler og farvestoffer. / i. as well as possibly otic lighting agents and dyes.
Videre kan det tilsettes overflateaktive substanser. F.eks. kan Furthermore, surface-active substances can be added. E.g. can
nevnes fettalkoholsulfater, salter av sulfonerte monoglycéridér av fettsyrer med 10 til 20 karbonatomer, fettsyre-eggehvite-kondensas jonsprodukter , salter av fettsyreamider og tauriner "og/éller salter av fettsyreestere av isetionsyre samt eventuelt ikke-ioniske, kationiske og/eller amfotere tensider. Det kan og- mention is made of fatty alcohol sulfates, salts of sulfonated monoglycerides of fatty acids with 10 to 20 carbon atoms, fatty acid-egg white condensation products, salts of fatty acid amides and taurines "and/or salts of fatty acid esters of isethionic acid and possibly non-ionic, cationic and/or amphoteric surfactants. can and-
så anvendes blandinger av de forskjellige overflateaktive stof- then mixtures of the different surfactants are used
fer. ferry.
Som nevnt ovenfor, skal tannpleiemidlets pH-verdi, ligge mellom As mentioned above, the toothpaste's pH value must lie between
4,5 og 6,5. Folgende eksempler er ment som illustrasjoner av foreliggende oppfinnelse. 4.5 and 6.5. The following examples are intended as illustrations of the present invention.
EKSEMPEL 1 - tannpasta EXAMPLE 1 - toothpaste
EKSEMPEL 2 - tannpasta EXAMPLE 2 - toothpaste
EKSEMPEL 3 - tannpasta EXAMPLE 3 - toothpaste
EKSEMPEL 4 - tannpasta EXAMPLE 4 - toothpaste
EKSEMPEL 5 - tannpasta EXAMPLE 5 - toothpaste
EKSEMPEL 6 - munnvann EKSEMPEL 7 - tannpulver EXAMPLE 6 - mouthwash EXAMPLE 7 - tooth powder
EKSEMPEL 8 - tannpulver EXAMPLE 8 - tooth powder
EKSEMPEL 9 - tannrensetabletter EKSEMPEL lo - tannrensetabletter EXAMPLE 9 - teeth cleaning tablets EXAMPLE lo - teeth cleaning tablets
EKSEMPEL 11 - tannpasta . EXAMPLE 11 - toothpaste.
Claims (2)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT760868A AT278247B (en) | 1968-08-05 | 1968-08-05 | Dentifrice with remineralizing properties |
| AT282969A AT286501B (en) | 1969-03-21 | 1969-03-21 | Dentifrice with remineralizing properties |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO130041B true NO130041B (en) | 1974-07-01 |
Family
ID=25599138
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO267469A NO130041B (en) | 1968-08-05 | 1969-06-26 |
Country Status (13)
| Country | Link |
|---|---|
| BE (1) | BE737082A (en) |
| CH (1) | CH517491A (en) |
| DE (1) | DE1936276C3 (en) |
| DK (1) | DK122707B (en) |
| FI (1) | FI50051C (en) |
| FR (1) | FR2015038A1 (en) |
| GB (1) | GB1222197A (en) |
| IE (1) | IE33101B1 (en) |
| IT (1) | IT1044771B (en) |
| LU (1) | LU59177A1 (en) |
| NO (1) | NO130041B (en) |
| RO (1) | RO54259A (en) |
| SE (1) | SE355725B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK155973B (en) * | 1979-12-19 | 1989-06-12 | Colgate Palmolive Co | TOOTHPASTE |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1938189A1 (en) * | 1969-07-28 | 1971-02-25 | Blendax Werke Schneider Co | Dental and oral care products containing enzymes |
| DE1943971A1 (en) * | 1969-08-29 | 1971-03-11 | Blendax Werke Schneider Co | Dentifrices |
| BE755331A (en) * | 1969-09-01 | 1971-02-01 | Blendax Werke Schneider Co | ORAL AND DENTAL CARE PRODUCTS |
| US4193988A (en) | 1971-04-29 | 1980-03-18 | Beecham Group Limited | Oral hygiene compositions |
| JPS5335139B2 (en) * | 1972-11-09 | 1978-09-26 | ||
| JPS5335136B2 (en) * | 1973-02-22 | 1978-09-26 | ||
| CH598821A5 (en) * | 1974-05-31 | 1978-05-12 | Gaba Ag | |
| GB1547874A (en) * | 1976-05-19 | 1979-06-27 | Unilever Ltd | Dentifrices |
| DE2752852B2 (en) * | 1977-11-26 | 1980-09-04 | Giulini Chemie Gmbh, 6700 Ludwigshafen | Dentifrices |
| US4292306A (en) | 1978-12-28 | 1981-09-29 | Faunce Frank R | Dentifrice with topical and systemic phosphate fluoride system |
| SE8005321L (en) * | 1979-07-31 | 1981-02-01 | Lion Corp | ORAL COMPOSITION |
| JPS5835965B2 (en) * | 1979-07-31 | 1983-08-05 | ライオン株式会社 | Oral composition |
| JPS5846483B2 (en) | 1979-09-20 | 1983-10-17 | ライオン株式会社 | Oral composition |
| CA1187417A (en) * | 1981-07-03 | 1985-05-21 | Jan Weststrate | Dentifrice |
| US4532124A (en) * | 1981-08-19 | 1985-07-30 | Development Finance Corporation Of New Zealand | Dental rinse |
| ATE28398T1 (en) * | 1982-04-20 | 1987-08-15 | Beecham Group Plc | AGENTS FOR ORAL HYGIENE. |
| GB8316382D0 (en) * | 1983-06-16 | 1983-07-20 | Beecham Group Plc | Toothpaste |
| GB8326974D0 (en) * | 1983-10-08 | 1983-11-09 | Beecham Group Plc | Oral hygiene composition |
| US5011830A (en) * | 1989-07-03 | 1991-04-30 | The Proctor & Gamble Company | Oral compositions having improved anticalculus properties containing pyrophosphate and an acrylic acid polymer |
| DE102006001148B4 (en) * | 2006-01-06 | 2008-03-27 | Henkel Kgaa | Oral and dental care and cleaners with enzyme (s) |
-
1969
- 1969-05-26 IE IE71769A patent/IE33101B1/en unknown
- 1969-06-05 GB GB2844469A patent/GB1222197A/en not_active Expired
- 1969-06-06 FR FR6918696A patent/FR2015038A1/fr not_active Withdrawn
- 1969-06-11 SE SE827769A patent/SE355725B/xx unknown
- 1969-06-26 NO NO267469A patent/NO130041B/no unknown
- 1969-07-05 IT IT1924969A patent/IT1044771B/en active
- 1969-07-08 RO RO6046469A patent/RO54259A/ro unknown
- 1969-07-10 FI FI205469A patent/FI50051C/en active
- 1969-07-17 DE DE19691936276 patent/DE1936276C3/en not_active Expired
- 1969-07-22 DK DK393869A patent/DK122707B/en unknown
- 1969-07-28 LU LU59177D patent/LU59177A1/xx unknown
- 1969-08-05 CH CH1188969A patent/CH517491A/en not_active IP Right Cessation
- 1969-08-05 BE BE737082D patent/BE737082A/xx unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK155973B (en) * | 1979-12-19 | 1989-06-12 | Colgate Palmolive Co | TOOTHPASTE |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1936276B2 (en) | 1974-08-29 |
| FI50051B (en) | 1975-09-01 |
| DK122707B (en) | 1972-04-04 |
| IE33101L (en) | 1970-02-05 |
| FR2015038A1 (en) | 1970-04-24 |
| IE33101B1 (en) | 1974-03-20 |
| FI50051C (en) | 1975-12-10 |
| CH517491A (en) | 1972-01-15 |
| RO54259A (en) | 1973-08-20 |
| LU59177A1 (en) | 1969-12-05 |
| SE355725B (en) | 1973-05-07 |
| DE1936276A1 (en) | 1970-02-19 |
| DE1936276C3 (en) | 1975-04-24 |
| IT1044771B (en) | 1980-04-21 |
| BE737082A (en) | 1970-01-16 |
| GB1222197A (en) | 1971-02-10 |
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