KR102622833B1 - Powder-type oral cleaner comprising hydroxy apatite - Google Patents

Abstract

The present invention relates to a powdered mouthwash containing hydroxyapatite, which has excellent plaque removal, tooth surface restoration, and tooth remineralization effects, and a powdered mouthwash containing hydroxyapatite, calcium carbonate, sodium bicarbonate, and xylitol powder. It is not only easy to carry, but also bio-friendly and can be easily used for oral health and bad breath removal.

Description

Powder-type oral cleaner comprising hydroxy apatite}

The present invention relates to a powder-type mouthwash containing hydroxyapatite.

When people eat food, bacterial activity in the oral cavity becomes active. Cavity-causing bacteria such as Streptococcus mutans (S. mutans) attach to the surface of teeth and metabolize food residues, producing organic acids, increasing the acidity in the mouth, which erodes tooth enamel and forms plaque, a bacterial film on the surface of teeth. form If left untreated, plaque gradually calcifies and forms dental calculus on the surface of the teeth. Bacteria and their metabolites in plaque and tartar cause not only dental caries but also an inflammatory response in periodontal tissue, causing periodontal disease. I also do it. Additionally, as food residues in the oral cavity are decomposed by microorganisms, volatile sulfides such as hydrogen sulfide, methyl mercaptan, dimethyl mercaptan, and ammonia are produced, causing bad breath (bad breath). .

To prevent cavities and periodontal disease and suppress bad breath, it is important to physically brush teeth to remove plaque and food residue. However, there is a problem in that plaque and food residue cannot be completely removed by toothbrushing alone. In particular, children and the elderly who have difficulty brushing their teeth thoroughly can easily develop cavities, periodontal disease, and bad breath. In these cases, mouthwashes or mouthwashes are used as an aid or replacement for brushing teeth. However, marketed mouthwashes contain many additives such as periodontal disease suppressing fragrances, whitening agents, colorants, sweeteners, surfactants, preservatives, abrasives, and synthetic antibacterial agents. Especially when mouthwashes are frequently used, antibacterial agents such as chlorhexidine are used. It can even kill all the good bacteria in the mouth, causing an imbalance in the normal bacterial flora, which can have negative effects such as mold forming in the mouth. In addition, mouthwashes that are generally provided in liquid form have problems such as leaking from the storage container and are not easy to carry.

Meanwhile, in the 1970s, the National Aeronautics and Space Administration (NASA) discovered hydroxyapatite as a material to restore mineral loss from the teeth and bones of astronauts living in zero gravity. Hydroxyapatite is a major component of the human body, accounting for 70% of tooth dentin, 97% of enamel, and 60% of bone. It is a material with excellent biocompatibility and is used as a material for bone and tissue restoration in artificial teeth. It is also abundant in saliva, so it replenishes lost minerals in the oral cavity and protects teeth from cavities through a natural healing process known as ‘remineralization.’ In other words, it absorbs and removes plaque, fills and restores microscopic scratches on the tooth surface, and remineralizes demineralized early cavities.

This hydroxyapatite has been mainly used in toothpaste and chewing gum. Korean Patent No. 1142305 describes a toothpaste composition containing nano-sized apatite carbonate that is effective in relieving sensitive teeth in patients with sensitive teeth, and Korean Patent No. 1272226 describes a toothpaste composition containing hydroxyapatite as a binder; Tablet-type toothpaste is manufactured by mixing abrasives, foaming agents, sweeteners, antioxidants, flavoring agents, etc. into tablets. However, in the case of children, disabled patients, or the elderly who are not skilled in dental care, careful brushing is not recommended. There is a problem that it is not easy, and there are limitations in removing food residue and plaque from every corner of the gums using the chewing gum form.

Korean Patent No. 1142305, Toothpaste composition for sensitive teeth containing nano-sized apatite carbonate, registered on April 26, 2012. Korean Patent No. 1272226, tablet-type toothpaste, 2013.05.31. registration.

The purpose of the present invention is to provide a powder-type mouthwash containing hydroxyapatite.

In order to solve the above problems, the present invention provides a powder-type mouthwash containing hydroxyapatite.

The hydroxyapatite is prepared in the first step of reacting calcium nitrate and phosphoric acid solution at 25°C for 30 minutes;

Step 2 of centrifuging the reaction product from step 1 at 2500 rpm for 2 minutes to obtain a pellet and washing it 2 to 3 times with distilled water;

Step 3 of drying the pellets from step 2 at 80°C for 48 hours; and

It can be manufactured according to a manufacturing method including the step of pulverizing the dried product of the above three steps. At this time, the phosphoric acid solution in step 1 may be H ₃ PO ₄ , KH ₂ PO ₄ , K ₂ HPO ₄ , NaH ₂ PO ₄ , Na ₂ HPO ₄ , etc., preferably H ₃ PO ₄ , but limited to these. That is not the case.

The powdered mouthwash is characterized in that it contains 100 parts by weight of hydroxyapatite powder, 100 to 200 parts by weight of xylitol powder, 50 to 100 parts by weight of sodium bicarbonate, and 50 to 100 parts by weight of calcium carbonate.

The powdered mouthwash may further include one or more functional powders selected from the group consisting of peppermint powder, turmeric powder, cinnamon powder, lettuce powder, and green tea powder.

The powdered mouthwash may further include a sweetener. The sweetener may be selected from the group consisting of sorbitol, dextrose, saccharin, white sugar, compressed sugar, starch syrup, honey, lactose, mannitol, fructose, and glucose, and sorbitol is preferably used. Sorbitol is a sweetener, but it also has a moisturizing effect and is non-irritating and harmless to the oral cavity. The sweetener may be included in an amount of 5 to 10% by weight based on the total weight of the composition of the present invention, and may be adjusted depending on the type and preference of the sweetener, but is not limited to the above range.

The present invention relates to a powdered mouthwash containing hydroxyapatite, which has excellent plaque removal, tooth surface restoration, and tooth remineralization effects, and a powdered mouthwash containing hydroxyapatite, calcium carbonate, sodium bicarbonate, and xylitol powder. It is not only easy to carry, but also bio-friendly and can be easily used for oral health and bad breath removal.

Figure 1 is a schematic diagram showing the manufacturing process of hydroxyapatite of the present invention.
Figure 2 is a photograph of the peppermint mixed powder mouthwash of the present invention.
Figure 3 is a photograph showing a plaque removal experiment of a liquid mouthwash (A) and a powder-type mouthwash (B) of the present invention.
Figure 4 is a comparative photograph showing the plaque removal aspects of the liquid mouthwash (A) and the powdery mouthwash (B) of the present invention before and after the plaque removal test.

Hereinafter, preferred embodiments of the present invention will be described in detail. However, the present invention is not limited to the embodiments described herein and may be embodied in other forms. Rather, the content introduced herein is provided to be thorough and complete, and to fully convey the spirit of the present invention to those skilled in the art.

< Example One. hydroxy Manufacturing of apatite>

To prepare a powder-type mouthwash containing hydroxyapatite of the present invention, hydroxyapatite was first prepared.

First, 100 ml of 0.4 M calcium nitrate (Ca(NO ₃ ) ₂ ) was mixed with 100 ml of 0.24 M phosphoric acid solution adjusted to pH 11-13, and stirred at 25°C for 30 minutes. Afterwards, it was centrifuged at 2500 rpm for 2 minutes to obtain a precipitate. At this time, the washing process of suspending the obtained precipitate in distilled water and centrifuging was repeated 2-3 times. The washed sediment was dried in a dry oven at 80°C for 48 hours. The dried hydroxyapatite was pulverized with a mixer, and the pulverized powder was filtered through a 100 to 300 mesh, preferably 200 mesh to prepare hydroxyapatite powder. The manufacturing process of the hydroxyapatite is shown in Figure 1.

< Example 2. Manufacturing of powdered mouthwash>

A powder-type mouthwash was prepared using the hydroxyapatite powder prepared in Example 1.

100 parts by weight of the hydroxyapatite powder of Example 1, 200 parts by weight of xylitol powder, 100 parts by weight of sodium bicarbonate, and 100 parts by weight of calcium carbonate were added to a mixer and mixed uniformly.

Xylitol is a natural sugar alcohol-based sweetener and is widely used in a variety of sugar-free products such as chewing gum, confectionery, pharmaceuticals, and oral hygiene products, and has an excellent volatilization effect when dissolved in the mouth. In particular, xylitol inhibits the growth of Streptococcus mutans , a representative cavity-causing bacteria, reduces the formation of plaque, a bacterial film on the tooth surface, and not only prevents enamel from being removed from teeth, but also acts to redeposit already removed enamel. .

Sodium bicarbonate, also known as baking soda, is harmless to the human body and is also a raw material for baking powder. With a hydrogen ion index pH of 8.3, it is slightly alkaline, and as a deodorant, it is effective in neutralizing and eliminating the odor of acidic substances, helping to eliminate bad breath.

Calcium carbonate acts as a powerful natural abrasive for teeth. When the radioactive dentin abrasion (RDA) of calcium pyrophosphate is expressed as 100, calcium carbonate is known to be between 100 and 200, so it is effective when used for strong cleaning of teeth.

The composition described above is a powder mixture that has good preservability at room temperature and does not clump up easily, making it very suitable as a portable mouthwash. In particular, it can remove plaque and eliminate bad breath without excessively suppressing oral microorganisms through antibacterial agents.

< Example 3. Manufacturing of mixed powder mouthwash>

Functional powders can be added to the powdered mouthwash of Example 2 to add effects such as removing bad breath, whitening teeth, and reducing sore throat. In particular, mixing functional powders with unique colors can enhance visual refreshing.

Example 3-1 Add peppermint powder

100 parts by weight of hydroxyapatite powder, 200 parts by weight of xylitol powder, 100 parts by weight of sodium bicarbonate, and 100 parts by weight of calcium carbonate were added to 100 parts by weight of peppermint powder in a mixer and mixed evenly. The appearance of the prepared peppermint powder mixed powder mouthwash is shown in Figure 2.

Peppermint leaves have been used since ancient times to refresh the mouth and whiten teeth. In particular, the menthol contained in peppermint has been found to be more effective in preventing inflammation in the mouth than the mouthwash chemical chlorhexidine.

Example 3-2 Add other powders

In addition to the peppermint powder of Example 3-1, turmeric, cinnamon, ginger, lettuce, or green tea powder can be added. Turmeric is a natural product that has been traditionally used in India for dental health. The root of turmeric contains curcumine, which is known to not only whiten teeth but also protect the heart, improve immune function, have anticancer properties, and improve depression and digestive disorders. Turmeric powder is used by mixing 1 to 10 parts by weight per 100 parts by weight of hydroxyapatite. At this time, the mixed powder mouthwash containing turmeric powder has a bright yellow color, and the mixed powder mouthwash containing cinnamon powder has a bright cinnamon color.

In addition, the essential oil components of cinnamon are very effective in whitening teeth and eliminating bad breath, and polyphenols are effective in controlling blood sugar levels and high blood pressure along with whitening teeth. Raffinose, a natural substance in ginger, prevents bacterial infection on the tooth surface and inhibits tooth decay. Cinnamon and ginger are used in a mixture of 1 to 10 parts by weight per 100 parts by weight of hydroxyapatite. Lettuce and green tea powder, which have been used for teeth whitening since ancient times, can be used in an amount of 10 to 50 parts by weight, respectively, for 100 parts by weight of hydroxyapatite. Powdered mouthwash mixed with lettuce powder, especially green tea powder, has a bright green color. As described above, the white color of hydroxyapatite becomes an overall bright pastel color when mixed with the functional powder, so it can have a decorative effect when carried in a transparent container.

The mixed powder mouthwash has a bright pastel color overall when mixed with the functional powder, so it can have a decorative effect when carried in a transparent container. Peppermint (white), turmeric (bright yellow), You can optionally carry cinnamon (light cinnamon color) or lettuce/green tea (light green) mixed powder mouthwash in a transparent container, or stack it in layers by color to enhance the aesthetics of the rainbow color.

The powder-type mouthwash of the present invention can be used lightly every day, and can benefit not only teeth but also health by adding functional powder as described above.

< Example 4. Confirm the plaque removal effect of powdered mouthwash>

The plaque removal effect was confirmed using the mixed powder mouthwash of Example 3-1.

A commercial liquid mouthwash (Listerine) was set as a control, and a suspension was prepared with physiological saline solution to mimic the mixing of the powder-type mouthwash of the present invention with saliva in the mouth, and each was placed in a container. Here, the tooth model with artificial plaque applied was placed in each container, and then the tooth model with artificial plaque attached was shaken left and right 30 times each inside the container containing liquid or powdered mouthwash, imitating gargling. The experimental process is shown in Figure 3.

Afterwards, the tooth model was taken out and irradiated with ultraviolet light in a dark room to confirm the plaque remaining on the tooth model, as shown in Figure 4. The above process was repeated 3 times.

As shown in Figure 4, compared to the liquid mouthwash (Listerine), the powder-type mouthwash of the present invention had a higher overall plaque removal efficiency. In particular, in the case of plaque located between teeth, liquid mouthwash hardly removed it, while powdered mouthwash was effective in removing plaque between teeth. Based on the above results, it was confirmed that the powdered mouthwash of the present invention can more effectively remove plaque from areas that are difficult to clean completely by brushing, such as the deep inner side of the molars, the inside of the front teeth, the interdental area, and the periodontal pocket area. This confirms that the powdered mouthwash of the present invention can be used as a toothbrushing aid for busy modern people such as office workers, and that it can contribute to the oral health of the elderly, the disabled, and children who feel uncomfortable brushing their teeth.

Claims (4)

In the powdered mouthwash containing hydroxyapatite,
The powdered mouthwash includes 100 parts by weight of hydroxyapatite powder, 100 to 200 parts by weight of xylitol powder, 50 to 100 parts by weight of sodium bicarbonate, and 50 to 100 parts by weight of calcium carbonate,
The powder-type mouthwash is a powder-type mouthwash, characterized in that it is used to remove dental plaque between teeth. According to paragraph 1,
The hydroxyapatite is prepared in the first step of reacting calcium nitrate and phosphoric acid solution at 25°C for 30 minutes;
Step 2 of centrifuging the reaction product from step 1 at 2500 rpm for 2 minutes to obtain a pellet and washing it 2 to 3 times with distilled water;
Step 3 of drying the pellets from step 2 at 80°C for 48 hours; and
A powder-type mouthwash, characterized in that it is manufactured according to a manufacturing method comprising the fourth step of pulverizing the dried material of the three steps above. delete According to paragraph 1,
A powder-type mouthwash, characterized in that the powder-type mouthwash further comprises one or more functional powders selected from the group consisting of peppermint powder, turmeric powder, cinnamon powder, lettuce powder, and green tea powder.