KR20220117720A - Powder-type oral cleaner comprising hydroxy apatite - Google Patents

Abstract

The present invention relates to a powder-type mouthwash comprising hydroxyapatite. The mouthwash comprising hydroxyapatite, calcium carbonate, sodium bicarbonate, and xylitol powder, which have excellent plaque removal, tooth surface restoration, and tooth remineralization, is in powder form. Therefore, the mouthwash is easy to carry, bio-friendly, and can be easily used for oral health and bad breath removal.

Description

Powder-type oral cleaner comprising hydroxy apatite

The present invention relates to a powder-type mouthwash comprising hydroxyapatite.

When people eat food, the bacterial activity in the mouth becomes active. Caries bacteria such as Streptococcus mutans (S. mutans) attach to the tooth surface and metabolize food residues to produce organic acid, which increases the acidity in the mouth, which corrodes the tooth enamel, and forms plaque, a bacterial film, on the tooth surface. to form If left unattended, the plaque gradually calcifies and forms dental calculus on the surface of the teeth. also do In addition, food residues in the oral cavity are decomposed by microorganisms to produce volatile sulfides, such as hydrogen sulfide, methyl mercaptan, dimethyl mercaptan, ammonia, etc., resulting in bad breath. .

In order to prevent tooth decay and periodontal disease and to suppress the occurrence of bad breath, it is important to physically wipe the teeth to remove plaque and food residues. However, there is a problem in that plaque or food residues cannot be completely removed by brushing alone. In particular, in the case of children or the elderly who have difficulty brushing their teeth thoroughly, problems of tooth decay, periodontal disease, and bad breath occur easily. In this case, a mouthwash or gargle is used as a substitute for brushing or as an aid to brushing teeth. However, in the case of gargles on sale, many additives such as periodontal disease inhibitory fragrances, whitening agents, coloring agents, sweeteners, surfactants, preservatives, abrasives, synthetic antibacterial agents are included. By removing all the good bacteria in the mouth, it can cause an imbalance in the normal bacterial flora, causing mold to form in the mouth. Also, gargles that are generally provided in a liquid form have a problem in that they are not easy to carry, such as leaking from the storage container.

Meanwhile, in the 1970s, the National Aeronautics and Space Administration (NASA) discovered hydroxyapatite as a material to restore minerals from the teeth and bones of astronauts living in zero gravity. Hydroxyapatite is a major component of the human body, accounting for 70% of tooth dentin, 97% of enamel, and 60% of bone. In addition, it is abundantly contained in saliva, and by replenishing the lost minerals in the oral cavity, it protects teeth from tooth decay through a natural healing process known as 'remineralization'. That is, it adsorbs and removes plaque, fills and repairs micro-scratches on the tooth surface, and remineralizes demineralized initial cavities.

This hydroxyapatite has been mainly used in toothpaste and chewing gum. Korean Patent No. 1142305 discloses a toothpaste composition containing nano-sized apatite carbonate, which has an effect of relieving pain in patients with hypersensitivity teeth, and Korean Patent No. 1272226 discloses a binder in hydroxyapatite, Tablet-type toothpaste is prepared by mixing and tableting abrasives, foaming agents, sweeteners, antioxidants, and flavoring agents. There is a problem that is not easy, and there is a limit to removing food residues and plaque from every corner of the gum in the form of chewing gum.

Korean Patent No. 1142305, Toothpaste composition for hypersensitive teeth containing nano-sized carbonic apatite, registered on April 26, 2012. Korean Patent Registration No. 1272226, tablet-type toothpaste, 2013.05.31. registration.

It is an object of the present invention to provide a powder-type mouthwash containing hydroxyapatite.

In order to solve the above problems, the present invention provides a powder-type mouthwash containing hydroxyapatite.

Step 1 of reacting the hydroxyapatite with a calcium nitrate and phosphoric acid solution at 25° C. for 30 minutes;

a second step of centrifuging the reaction product of step 1 at 2500 rpm for 2 minutes to obtain a pellet and washing 2-3 times with distilled water;

Step 3 of drying the pellets of step 2 at 80° C. for 48 hours; and

It may be prepared according to a manufacturing method comprising; pulverizing the dried product of the three steps. In this case, the phosphoric acid solution of step 1 may include H ₃ PO ₄ , KH ₂ PO ₄ , K ₂ HPO ₄ , NaH ₂ PO ₄ , Na ₂ HPO ₄ , etc., preferably H ₃ PO ₄ , but limited thereto it is not

The powder-type mouthwash is characterized in that it contains 100 parts by weight of hydroxyapatite powder, 100 to 200 parts by weight of xylitol powder, 50 to 100 parts by weight of sodium bicarbonate, and 50 to 100 parts by weight of calcium carbonate.

The powder-type mouthwash may further include at least one functional powder selected from the group consisting of peppermint powder, turmeric powder, cinnamon powder, lettuce powder, and green tea powder.

The powder-type mouthwash may further include a sweetener. The sweetener may be selected from the group consisting of sorbitol, dextrose, saccharin, sucrose, compressed sugar, starch syrup, honey, lactose, mannitol, fructose and glucose, and sorbitol may be preferably used. Sorbitol is a sweetening agent, but it also has a moisturizing effect and has less irritation to the oral cavity and is harmless. The sweetener may be included in 5 to 10% by weight based on the total weight of the composition of the present invention, and may be adjusted according to the type and preference of the sweetener, but is not limited to the above range.

The present invention relates to a powder-type mouthwash containing hydroxyapatite, comprising hydroxyapatite, calcium carbonate, sodium bicarbonate, and xylitol powder having excellent plaque removal, dental restoration and tooth remineralization effects. It is not only easy to carry, but also bio-friendly and can be easily used for oral health and bad breath removal.

1 is a schematic diagram showing a manufacturing process of hydroxyapatite of the present invention.
2 is a photograph of the peppermint mixed powder mouthwash of the present invention.
3 is a photograph showing a plaque removal experiment of the liquid mouthwash (A) and the powder mouthwash (B) of the present invention.
4 is a comparative photograph showing the plaque removal aspects before and after the plaque removal experiment of the liquid mouthwash (A) and the powder mouthwash (B) of the present invention.

Hereinafter, preferred embodiments of the present invention will be described in detail. However, the present invention is not limited to the embodiments described herein and may be embodied in other forms. Rather, it is provided so that this disclosure will be thorough and complete, and will fully convey the spirit of the invention to those skilled in the art.

< Example One. hydroxy Manufacture of apatite>

In order to prepare a powder-type mouthwash containing hydroxyapatite of the present invention, hydroxyapatite was first prepared.

First, 100 ml of 0.4 M calcium nitrate (Ca(NO ₃ ) ₂ ) was mixed with 100 ml of a 0.24 M phosphoric acid solution adjusted to pH 11-13, and stirred at 25° C. for 30 minutes. Thereafter, it was centrifuged at 2500 rpm for 2 minutes to obtain a precipitate. The resulting precipitate was suspended in distilled water and the washing process of centrifugation was repeated 2-3 times. The washed precipitate was dried in a dry oven at 80°C for 48 hours. The dried hydroxyapatite was pulverized with a mixer, and the pulverized powder was filtered through 100 to 300 mesh, preferably 200 mesh, to prepare hydroxyapatite powder. The manufacturing process of the hydroxyapatite is shown in FIG. 1 .

< Example 2. Preparation of powder mouthwash>

A powder-type mouthwash was prepared using the hydroxyapatite powder prepared in Example 1.

100 parts by weight of the hydroxyapatite powder of Example 1, 200 parts by weight of the xylitol powder, 100 parts by weight of sodium bicarbonate, and 100 parts by weight of calcium carbonate were placed in a mixer and uniformly mixed.

Xylitol is a natural sugar alcohol-based sweetener and is widely used in various sugar-free products such as chewing gum, confectionery, pharmaceuticals and oral hygiene products. In particular, xylitol inhibits the growth of Streptococcus mutans , a representative caries-causing bacterium, reduces the formation of plaque, a bacterial film on the tooth surface, prevents enamel from being separated from teeth, and also acts to re-deposit the already separated enamel. .

Sodium bicarbonate, also known as baking soda, is harmless to the human body and is a raw material for baking powder. It belongs to weak alkali with a hydrogen ion index pH of 8.3, and as a deodorant, it has the effect of neutralizing and removing the odor of acidic substances, which helps to remove bad breath.

Calcium carbonate acts as a powerful natural abrasive for teeth. When the radioactive dentin abrasion (RDA) of calcium pyrophosphate is expressed as 100, calcium carbonate is known to be between 100 and 200, so it is effective when used for strong cleaning of teeth.

The above composition is a powder mixture, which has good preservation at room temperature and is not well agglomerated, so it is very suitable as a portable mouthwash. In particular, it is possible to remove plaque and remove bad breath without excessively suppressing oral microorganisms through antibacterial agents or the like.

< Example 3. Preparation of Mixed Powder Mouthwash>

By adding a functional powder to the powder-type mouthwash of Example 2, effects such as removing bad breath, whitening teeth, and reducing sore throat can be added. In particular, by mixing a functional powder having a unique color, it is possible to increase the visual refreshing feeling.

Example Add 3-1 Peppermint Powder

100 parts by weight of hydroxyapatite powder, 200 parts by weight of xylitol powder, 100 parts by weight of sodium bicarbonate and 100 parts by weight of calcium carbonate were placed in a mixer and mixed uniformly. The appearance of the prepared peppermint powder mixed powder mouthwash is shown in FIG. 2 .

Peppermint leaves have been used since ancient times to freshen the mouth and whiten teeth. In particular, the menthol contained in peppermint has been shown to act more strongly than the mouthwash chemical chlorhexidine, which prevents inflammation in the mouth.

Example 3-2 Add other powders

In addition to the peppermint powder of Example 3-1, turmeric, cinnamon, ginger, lettuce or green tea powder may be added. Turmeric is a natural product that has been traditionally used for dental health in India. The root of turmeric contains curcumin, which is known not only for teeth whitening, but also for heart protection, immune function improvement, anticancer action, and improvement of depression and digestive disorders. Turmeric powder is used by mixing 1 to 10 parts by weight based on 100 parts by weight of hydroxyapatite. At this time, the mixed powder mouthwash containing turmeric powder has a bright yellow color, and the mixed powder type mouthwash containing cinnamon powder has a bright cinnamon color.

In addition, the essential oil component of cinnamon is very effective in whitening teeth and removing bad breath, and polyphenol is effective in controlling blood sugar and high blood pressure along with teeth whitening. Raffinose, a natural substance in ginger, inhibits tooth decay by preventing bacterial infection on the tooth surface. Cinnamon and ginger are used in a mixture of 1 to 10 parts by weight, respectively, based on 100 parts by weight of hydroxyapatite. Lettuce and green tea powder, which have been used for teeth whitening since ancient times, may be used in an amount of 10 to 50 parts by weight based on 100 parts by weight of hydroxyapatite. A mixed powdered mouthwash with lettuce powder, especially green tea powder, has a bright green color. As described above, since the white color of hydroxyapatite is mixed with the functional powder and has a bright pastel color as a whole, it can exhibit a decorative effect when carried in a transparent container.

The mixed powder mouthwash has a decorative effect when carried in a transparent container because the white color of hydroxyapatite is mixed with the functional powder and has a bright pastel color as a whole, peppermint (white), turmeric (light yellow), Cinnamon (bright cinnamon color), lettuce/green tea (light green) mixed powder mouthwash can be optionally carried in a transparent container or layered by color to enhance the aesthetics with iridescent colors.

The powder-type mouthwash of the present invention can be used lightly every day, and by adding the functional powder as described above, it can help not only teeth but also health.

< Example 4. Confirmation of Plaque Removal Effect of Powder Mouthwash>

The effect of removing plaque was confirmed by using the mixed powder mouthwash of Example 3-1.

A commercial liquid mouthwash (Listerine) was set as a control, and a suspension was prepared with physiological saline by mimicking the mixing of the powdered mouthwash of the present invention with saliva in the mouth, and each was placed in a container. After placing the dental model coated with artificial plaque in each container, the tooth model with artificial plaque was shaken left and right 30 times in a container containing a liquid or powder mouthwash by mimicking gargling. The experimental procedure is shown in FIG. 3 .

Thereafter, the tooth model was taken out and irradiated with ultraviolet light in a dark room to check the plaque remaining on the tooth model, and is shown in FIG. 4 . The above process was repeated 3 times.

As shown in FIG. 4 , the powder mouthwash of the present invention had higher overall plaque removal efficiency than the liquid mouthwash (Listerine). In particular, in the case of plaque located between the teeth, the liquid mouthwash hardly removed it, whereas the powder-type mouthwash was effective in removing the plaque in the interdental space. From the above results, it was confirmed that the powder-type mouthwash of the present invention can more effectively remove plaque in areas that are difficult to completely clean, such as deep inner side of molars, inner incisors, interdental, and periodontal pockets, by brushing. This confirms that the powdered mouthwash of the present invention can be used as an aid to brushing teeth of busy modern people such as office workers, and can contribute to the oral health of the elderly, the disabled, and children who feel uncomfortable brushing teeth.

Claims (4)

A powdered mouthwash containing hydroxyapatite. According to claim 1,
Step 1 of reacting the hydroxyapatite with a calcium nitrate and phosphoric acid solution at 25° C. for 30 minutes;
a second step of centrifuging the reaction product of step 1 at 2500 rpm for 2 minutes to obtain a pellet and washing 2-3 times with distilled water;
Step 3 of drying the pellets of step 2 at 80° C. for 48 hours; and
A powder mouthwash, characterized in that it is manufactured according to a manufacturing method comprising; step 4 of pulverizing the dried product of step 3 above. According to claim 1,
The powder mouthwash, 100 parts by weight of hydroxyapatite powder, 100 to 200 parts by weight of xylitol powder, 50 to 100 parts by weight of sodium bicarbonate, and 50 to 100 parts by weight of calcium carbonate. 4. The method of claim 3,
Powder mouthwash, characterized in that it further comprises at least one functional powder selected from the group consisting of peppermint powder, turmeric powder, cinnamon powder, lettuce powder and green tea powder in the powdery mouthwash.

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