CN107661228A - A kind of multiple-effect toothpaste of the mineral element containing the tremolite - Google Patents
A kind of multiple-effect toothpaste of the mineral element containing the tremolite Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention discloses a kind of multiple-effect toothpaste of mineral element containing the tremolite, this toothpaste are composed of the following components：Lauryl sodium sulfate, sodium carboxymethylcellulose, xanthans, saccharin sodium, methyl p-hydroxybenzoate, allantoin, tremolite miberal powder, strontium carbonate, silica, calcium carbonate, glucose oxidase, sodium phytate, calcium pyrophosphate, deionized water；Toothpaste of the present invention not only makes tremolite ore deposit heel obtain secondary use, and has good inhibiting effect to streptococcus mutans, porphyromonas gingivalis, and has anti-allergic effects；Toothpaste of the present invention can also dispel the generation that dental plaque prevents tooth stain, remove the glucose of tooth attachment, prevent bacteria breed, preferably take care of one's teeth, and long-term use of toothpaste of the present invention, can reach the effect of good tooth-whitening.
Description
Technical field
The present invention relates to daily chemical products field, and in particular to a kind of multiple-effect toothpaste of mineral element containing the tremolite.
Background technology
Toothpaste turns into the necessity of people's daily life already, and with the continuous improvement of living standard, toothpaste is by common
The type that cleans the teeth develops to curative effect-type, or even develops to multiple-effect type.The additive added by multiple-effect type toothpaste is mostly peroxide at present
Compound, solvent-borne type compound or high friction valve compound, or simultaneously added with several above type of compounds.Peroxide
Compound, there is obvious multiple-effect to act on, but such compound is extremely unstable, the proportioning poor-performing with the other components of toothpaste,
Its using effect is have impact on, and peroxide is used for oral cavity, and its security is restricted.Solvent-borne type additive such as polyethylene glycol
Play the role of necessarily to dissolve color spot, but DeGrain, and cost is not also low.Height friction value compound such as calcium phosphate dibasic anhydrous
Deng easily fray enamel.
It has been confirmed that, among carious tooth and chronic periodontitis (gum disease) both most common mouth diseases, dental plaque
Bacterium is main pathogenic factor.The prevention of both diseases of past focuses primarily upon the cleaning and maintenance of oral hygiene, including
Tartar is removed with toothbrush mechanical, or (is such as removed with other methods with wax wire or toothpick), later, people are tended to using fluorination
Thing, and fluoride has no effect to tartar bacterium, can only prevent tooth surface decalcification.Consider prevention the various of gum disease to arrange
Apply, machinery still takes advantage except tartar prevents the disease, and it is the most commonly used and most general to carry out oral cleaning with toothpaste and toothbrush
And method.
Tremolite ore deposit is worth high nonmetallic minerals as a kind of, its have can exploring mining the characteristics of.Exploitation is dodged thoroughly
Stone ore, substantial amounts of heel is inevitably resulted from, and still can profit containing active ingredient or element in tremolite ore deposit heel
With the waste of resource can be caused by abandoning tremolite ore deposit heel.
Chinese patent application (CN200610047542.X), discloses a kind of toothpaste prepared from natural jade mineral, including with the following group
Point：Magnesia MgO, silica SiO2, calcium oxide CaO, crystallization water H2O and selenium, zinc, nickel, copper, cobalt, manganese various trace elements
Soapstone or serpentine-jade or Khotan jade, the Nanyang jade jade fine powder of composition；This toothpaste utilizes natural jade medical health care function
It is safe and non-toxic to substitute the rubbing agent in conventional dentifrices, bactericide, preservative, any adverse side effect will not be produced, is made for a long time
With not only having good cleaning-nursing to act on to tooth and oral cavity, various tooth diseases and mouth disease are prevented and treated, while can also be effective
Inorganic microelement and mineral nutrition are provided；But the granularity of this toothpaste jade fine powder is 1nm~1mm, granularity mistake in toothpaste
Damage tooth and gum are likely to greatly, and prevents and treats the effect and unobvious of various tooth diseases and mouth disease.
The content of the invention
In view of the above-mentioned problems, the invention provides a kind of multiple-effect toothpaste of mineral element containing the tremolite, this toothpaste uses
The strontium carbonate and tremolite miberal powder prepared by tremolite ore deposit heel, not only makes the tremolite ore deposit heel obtain secondary use, and institute
Obtained toothpaste has good inhibiting effect to streptococcus mutans, porphyromonas gingivalis, and has anti-allergic effects；Dodge thoroughly
Containing materials such as titanium dioxide, calcium oxide in stone ore powder, multiple-effect toothpaste of the present invention is set to dispel the life that dental plaque prevents tooth stain
Into preferably taking care of one's teeth；Toothpaste of the present invention with the addition of glucose oxidase, can effectively remove the glucose of tooth attachment, prevent
Only bacteria breed, therefore, long-term use of toothpaste of the present invention, it can reach the effect of good tooth-whitening.
The present invention is achieved through the following technical solutions：
The multiple-effect toothpaste of a kind of mineral element containing the tremolite, by the material composition of following parts by weight：Lauryl sodium sulfate
It is 1-3 parts, sodium carboxymethylcellulose 0.1-0.3 parts, xanthans 0.05-0.15 parts, spices 1-2 parts, saccharin sodium 0.05-0.2 parts, sweet
Oily 15-30 parts, methyl p-hydroxybenzoate 0.05-0.3 parts, allantoin 0.1-0.3 parts, tremolite miberal powder 10-20 parts, strontium carbonate
0.2-0.5 parts, -7 parts of silica 1, calcium carbonate 5-10 parts, glucose oxidase part 0.05-0.1 parts, sodium phytate 2-5 parts, Jiao
Calcium phosphate 15-30 parts, deionized water 30-50 parts.
Preferably, the multiple-effect toothpaste of a kind of mineral element containing the tremolite, by the material composition of following parts by weight：Dodecyl
2 parts of sodium sulphate, 0.2 part of sodium carboxymethylcellulose, 0.1 part of xanthans, 1 part of spices, 0.1 part of saccharin sodium, 20 parts of glycerine, to hydroxyl
0.15 part of methyl benzoate, 0.2 part of allantoin, 15 parts of tremolite miberal powder, 0.3 part of strontium carbonate, 5 parts of silica, calcium carbonate 8
Part, 0.1 part of glucose oxidase part, 3 parts of sodium phytate, 22 parts of calcium pyrophosphate, 40 parts of deionized water.
Preferably, a kind of multiple-effect toothpaste of mineral element containing the tremolite, the preparation method of described tremolite miberal powder are：
(1) take tremolite ore deposit leftover bits and pieces to pulverize 100 mesh sieves, obtain the powder that granularity is not more than 150 μm；(2) step (1) is obtained
Powder ultramicro grinding, obtain the powder that granularity is not more than 50 μm, as tremolite miberal powder.
Preferably, described tremolite miberal powder includes following component：The tremolite, sodium oxide molybdena, magnesia, calcium oxide, oxidation
Aluminium, iron oxide, potassium oxide, zinc oxide, titanium dioxide, ratio of these raw materials in tremolite miberal powder are the tremolite：Sodium oxide molybdena:
Magnesia:Calcium oxide:Aluminum oxide:Iron oxide:Potassium oxide:Zinc oxide:Titanium dioxide=(800-1000)：(5-6):(60-65):
(25-30):(2-2.5):(6-8):(1-2):(0.05-0.08):(2-2.5)。
Preferably, a kind of multiple-effect toothpaste of mineral element containing the tremolite, the preparation method of described strontium carbonate are：(1) take
Tremolite ore deposit leftover bits and pieces pulverized 200 mesh sieves, obtained granularity≤0.075mm powder；(2) powder that will be obtained in step (1)
Be placed in reactor and mixed with water, uniform stirring, be slowly added to 12mol/L hydrochloric acid, add the volume of hydrochloric acid for water ten/
One, blowup is passed through, then pours out all filtrates, saturation NaOH solution is added into filtrate to filtrate in neutrality；(3) to step
Suddenly neutral filtrate addition soda ash obtained by (2), adds water to stir, solid-to-liquid ratio 1:1, then steam heating is passed through, 7h is reacted, it is heavy to collect
Form sediment；(4) precipitation in step (3) is washed repeatedly with purified water repeatedly in neutrality, is then slowly added into 50% thereto
Dust technology, after solution ph is adjusted to 4~5, appropriate steam is passed through, adds saturation NaOH solution, added to the pH value of solution
For 14.It is 6 that 50% dust technology regulation pH is added dropwise into this solution, is filtrated to get precipitation；(5) it is deposited in what step (4) obtained
24h is dried at 180~200 DEG C, dried precipitation is obtained into the SrCO of granularity≤50 μm through ultramicro grinding3, as strontium carbonate.
A kind of preparation method of the multiple-effect toothpaste of mineral element containing the tremolite is provided here, comprised the following steps：(1) will be sweet
In oil, sodium carboxymethylcellulose input glue pot, wetting stirring, the raw material such as the saccharin sodium dissolved, deionized water are added,
Continue to stir, it is in uniform translucent viscous shape liquid to make manufactured glue, is then stored, and allows its dissolve fully to use after expanding；(2)
By glue obtained by step (1) and lauryl sodium sulfate, xanthans, spices, methyl p-hydroxybenzoate, allantoin, the tremolite
Miberal powder, strontium carbonate, silica, calcium carbonate, glucose oxidase, sodium phytate, calcium pyrophosphate, deionized water input block conjunction pot
It is interior, stirred, be made with certain sticky, dilute thick appropriate lotion by mechanical mixture；(3) cream for obtaining step (2)
Body is ground by grinder, makes lotion fine and smooth, uniformly, stably, grinding is carried out in two times, is stored after grinding for the first time, is ground for the second time
Vacuum outgas is carried out after mill, untill vacuum reaches -0.096Mpa, the time is about 50min, and lotion degassing stands 3h, obtained
To product.
Strontium carbonate：It is white powder or particle, odorless, tasteless.Strontium carbonate is the inorganic industrial raw material of important role, main
It is used for the preparing raw material of electronic ceramics, metallurgy, fireworks, color picture tube glass bulb, magnetic material and other strontium salts, strontium carbonate resistance
The dentinal tubule that plug opens reaches desensitization effect.
Glucose oxidase：Glucose oxidase is a kind of important industrial enzymes in food industry, is widely used in grape
The deoxidation of the food such as wine, beer, fruit juice, milk powder, flour improvement, food brown stain etc. is prevented, in food science literature and biology
Also it is widely used on sensor.Glucose oxidase can remove residual and the glucose of tooth attachment in oral cavity.
Tremolite miberal powder：The tremolite, the normal radial or columnar arrangement of crystal, molecular formula Ca2Mg5(OH)2(Si4O11)2。
After tremolite miberal powder in the present invention obtains powder of the granularity no more than 150 μm for ground 100 mesh sieve of tremolite ore deposit leftover bits and pieces,
Through ultramicro grinding, obtained granularity is not more than 50 μm of powder.
Beneficial effects of the present invention：
Toothpaste of the present invention has used the strontium carbonate and tremolite miberal powder prepared by tremolite ore deposit heel, to tremolite ore deposit heel
Secondary use, containing materials such as titanium dioxide, calcium oxide in tremolite miberal powder, multiple-effect toothpaste of the present invention is set to dispel dental plaque
The generation of tooth stain is prevented, coordinates strontium carbonate multiple-effect toothpaste of the present invention is had well streptococcus mutans, porphyromonas gingivalis
Inhibitory action, then glucose oxidase is compounded, the glucose of tooth attachment can be effectively removed, bacteria breed is prevented and treated, reaches
The effect of good tooth-whitening.
Embodiment
Embodiment 1
The multiple-effect toothpaste of a kind of mineral element containing the tremolite, by the material composition of following parts by weight：Lauryl sodium sulfate 1
Part, 0.1 part of sodium carboxymethylcellulose, 0.05 part of xanthans, 1 part of spices, 0.05 part of saccharin sodium, 15 parts of glycerine, para hydroxybenzene first
Sour 0.05 part of methyl esters, 0.1 part of allantoin, 10 parts of tremolite miberal powder, 0.2 part of strontium carbonate, silica 1 part, 5 parts of calcium carbonate, Portugal
0.05 part of grape carbohydrate oxidase part, 2 parts of sodium phytate, 15 parts of calcium pyrophosphate, 50 parts of deionized water.
The preparation method of described tremolite miberal powder is：(1) take tremolite ore deposit leftover bits and pieces to pulverize 100 mesh sieves, obtain grain
Powder of the degree no more than 150 μm；(2) the powder ultramicro grinding for obtaining step (1), the powder that granularity is not more than 50 μm is obtained,
As tremolite miberal powder.
The preparation method of described strontium carbonate is：(1) take tremolite ore deposit leftover bits and pieces to pulverize 200 mesh sieves, obtain granularity≤
0.075mm powder；(2) powder obtained in step (1) is placed in reactor and mixed with water, uniform stirring, is slowly added to
12mol/L hydrochloric acid, the volume for adding hydrochloric acid is 1/10th of water, is passed through blowup, then pours out all filtrates, to filtrate
Middle addition saturation NaOH solution is to filtrate in neutrality；(3) soda ash is added to neutral filtrate obtained by step (2), adds water to stir, solid-liquid
Than for 1:1, then steam heating is passed through, 7h is reacted, collects precipitation；(4) precipitation in step (3) is washed repeatedly with purified water more
It is secondary to be then slowly added into 50% dust technology thereto to being in neutrality, after solution ph is adjusted to 4~5, be passed through appropriate steam,
Saturation NaOH solution is added, the pH value added to solution is 14.It is 6 that 50% dust technology regulation pH is added dropwise into this solution, mistake
Filter is precipitated；(5) dry 24h is deposited at 180~200 DEG C by what step (4) obtained, by dried precipitation through Ultramicro-powder
It is broken to obtain the SrCO of granularity≤50 μm3, as strontium carbonate.
A kind of preparation method of the multiple-effect toothpaste of above-mentioned mineral element containing the tremolite, comprises the following steps：(1) by glycerine,
In sodium carboxymethylcellulose input glue pot, wetting stirring, the raw material such as the saccharin sodium dissolved, deionized water are added, after
Continuous stirring, it is in uniform translucent viscous shape liquid to make manufactured glue, is then stored, and allows its dissolve fully to be used after expanding；(2) will
Glue and lauryl sodium sulfate, xanthans, spices, methyl p-hydroxybenzoate, allantoin, tremolite ore deposit obtained by step (1)
Powder, strontium carbonate, silica, calcium carbonate, glucose oxidase, sodium phytate, calcium pyrophosphate, deionized water input are blocked and closed in pot,
Stirred, be made with certain sticky, dilute thick appropriate lotion by mechanical mixture；(3) lotion for obtaining step (2) passes through
Grinder grinding is crossed, makes lotion fine and smooth, uniformly, stably, grinding is carried out in two times, is stored after grinding for the first time, after second is ground
Vacuum outgas is carried out, untill vacuum reaches -0.096Mpa, the time is about 50min, and lotion degassing stands 3h, produced
Product.
Embodiment 2
The multiple-effect toothpaste of a kind of mineral element containing the tremolite, by the material composition of following parts by weight：Lauryl sodium sulfate 3
Part, 0.3 part of sodium carboxymethylcellulose, 0.15 part of xanthans, 2 parts of spices, 0.2 part of saccharin sodium, 30 parts of glycerine, P-hydroxybenzoic acid
0.3 part of methyl esters, 0.3 part of allantoin, 20 parts of tremolite miberal powder, 0.5 part of strontium carbonate, 7 parts of silica, 10 parts of calcium carbonate, grape
0.1 part of carbohydrate oxidase part, 5 parts of sodium phytate, 30 parts of calcium pyrophosphate, 30 parts of deionized water.
The preparation method of described tremolite miberal powder is：(1) take tremolite ore deposit leftover bits and pieces to pulverize 100 mesh sieves, obtain grain
Powder of the degree no more than 150 μm；(2) the powder ultramicro grinding for obtaining step (1), the powder that granularity is not more than 50 μm is obtained,
As tremolite miberal powder.
The preparation method of described strontium carbonate is：(1) take tremolite ore deposit leftover bits and pieces to pulverize 200 mesh sieves, obtain granularity≤
0.075mm powder；(2) powder obtained in step (1) is placed in reactor and mixed with water, uniform stirring, is slowly added to
12mol/L hydrochloric acid, the volume for adding hydrochloric acid is 1/10th of water, is passed through blowup, then pours out all filtrates, to filtrate
Middle addition saturation NaOH solution is to filtrate in neutrality；(3) soda ash is added to neutral filtrate obtained by step (2), adds water to stir, solid-liquid
Than for 1:1, then steam heating is passed through, 7h is reacted, collects precipitation；(4) precipitation in step (3) is washed repeatedly with purified water more
It is secondary to be then slowly added into 50% dust technology thereto to being in neutrality, after solution ph is adjusted to 4~5, be passed through appropriate steam,
Saturation NaOH solution is added, the pH value added to solution is 14.It is 6 that 50% dust technology regulation pH is added dropwise into this solution, mistake
Filter is precipitated；(5) dry 24h is deposited at 180~200 DEG C by what step (4) obtained, by dried precipitation through Ultramicro-powder
It is broken to obtain the SrCO of granularity≤50 μm3, as strontium carbonate.
A kind of preparation method of the multiple-effect toothpaste of above-mentioned mineral element containing the tremolite, comprises the following steps：(1) by glycerine,
In sodium carboxymethylcellulose input glue pot, wetting stirring, the raw material such as the saccharin sodium dissolved, deionized water are added, after
Continuous stirring, it is in uniform translucent viscous shape liquid to make manufactured glue, is then stored, and allows its dissolve fully to be used after expanding；(2) will
Glue and lauryl sodium sulfate, xanthans, spices, methyl p-hydroxybenzoate, allantoin, tremolite ore deposit obtained by step (1)
Powder, strontium carbonate, silica, calcium carbonate, glucose oxidase, sodium phytate, calcium pyrophosphate, deionized water input are blocked and closed in pot,
Stirred, be made with certain sticky, dilute thick appropriate lotion by mechanical mixture；(3) lotion for obtaining step (2) passes through
Grinder grinding is crossed, makes lotion fine and smooth, uniformly, stably, grinding is carried out in two times, is stored after grinding for the first time, after second is ground
Vacuum outgas is carried out, untill vacuum reaches -0.096Mpa, the time is about 50min, and lotion degassing stands 3h, produced
Product.
Embodiment 3
The multiple-effect toothpaste of a kind of mineral element containing the tremolite, by the material composition of following parts by weight：Lauryl sodium sulfate 1
Part, 0.1 part of sodium carboxymethylcellulose, 0.05 part of xanthans, 1 part of spices, 0.05 part of saccharin sodium, 15 parts of glycerine, para hydroxybenzene first
Sour 0.05 part of methyl esters, 0.1 part of allantoin, 10 parts of tremolite miberal powder, 0.2 part of strontium carbonate, silica 1 part, 5 parts of calcium carbonate, Portugal
0.05 part of grape carbohydrate oxidase part, 2 parts of sodium phytate, 15 parts of calcium pyrophosphate, 30 parts of deionized water.
The preparation method of described tremolite miberal powder is：(1) take tremolite ore deposit leftover bits and pieces to pulverize 100 mesh sieves, obtain grain
Powder of the degree no more than 150 μm；(2) the powder ultramicro grinding for obtaining step (1), the powder that granularity is not more than 50 μm is obtained,
As tremolite miberal powder.
The preparation method of described strontium carbonate is：(1) take tremolite ore deposit leftover bits and pieces to pulverize 200 mesh sieves, obtain granularity≤
0.075mm powder；(2) powder obtained in step (1) is placed in reactor and mixed with water, uniform stirring, is slowly added to
12mol/L hydrochloric acid, the volume for adding hydrochloric acid is 1/10th of water, is passed through blowup, then pours out all filtrates, to filtrate
Middle addition saturation NaOH solution is to filtrate in neutrality；(3) soda ash is added to neutral filtrate obtained by step (2), adds water to stir, solid-liquid
Than for 1:1, then steam heating is passed through, 7h is reacted, collects precipitation；(4) precipitation in step (3) is washed repeatedly with purified water more
It is secondary to be then slowly added into 50% dust technology thereto to being in neutrality, after solution ph is adjusted to 4~5, be passed through appropriate steam,
Saturation NaOH solution is added, the pH value added to solution is 14.It is 6 that 50% dust technology regulation pH is added dropwise into this solution, mistake
Filter is precipitated；(5) dry 24h is deposited at 180~200 DEG C by what step (4) obtained, by dried precipitation through Ultramicro-powder
It is broken to obtain the SrCO of granularity≤50 μm3, as strontium carbonate.
A kind of preparation method of the multiple-effect toothpaste of above-mentioned mineral element containing the tremolite, comprises the following steps：(1) by glycerine,
In sodium carboxymethylcellulose input glue pot, wetting stirring, the raw material such as the saccharin sodium dissolved, deionized water are added, after
Continuous stirring, it is in uniform translucent viscous shape liquid to make manufactured glue, is then stored, and allows its dissolve fully to be used after expanding；(2) will
Glue and lauryl sodium sulfate, xanthans, spices, methyl p-hydroxybenzoate, allantoin, tremolite ore deposit obtained by step (1)
Powder, strontium carbonate, silica, calcium carbonate, glucose oxidase, sodium phytate, calcium pyrophosphate, deionized water input are blocked and closed in pot,
Stirred, be made with certain sticky, dilute thick appropriate lotion by mechanical mixture；(3) lotion for obtaining step (2) passes through
Grinder grinding is crossed, makes lotion fine and smooth, uniformly, stably, grinding is carried out in two times, is stored after grinding for the first time, after second is ground
Vacuum outgas is carried out, untill vacuum reaches -0.096Mpa, the time is about 50min, and lotion degassing stands 3h, produced
Product.
Comparative example 1：Be not added with strontium carbonate and tremolite miberal powder with differing only in for embodiment 1, other preparation conditions and
Method is same as Example 1.
Comparative example 2：Be not added with glucose oxidase with differing only in for embodiment 1, other preparation conditions and method with
Embodiment 1 is identical.
Comparative example 3：Comparative example 2：For toothpaste obtained by Chinese patent application (CN200610047542.X).
Application Example 1
Bacteriostatic test
Using streptococcus mutans, porphyromonas gingivalis as test strain, 0.03mol/L phosphate buffers are as cloudy
Property control group, for embodiment 1-3 as test group, comparative example 1-3 carries out antibacterial effect as a control group, according to QB/T 2738-2012
Fruit is tested, as a result as shown in table 1：
Table 1
There is good suppression to streptococcus mutans and porphyromonas gingivalis by the visible toothpaste of the embodiment of the present invention 1~3 of table 1
Effect.
Application Example 2
Plaque index
To being counted using the Dental Plaque index before and after each embodiment and comparative example toothpaste.
144 adult men and women are divided into 6 groups, respectively brushed teeth once sooner or later daily using toothpaste, each toothpaste dosage is 2g.It is right
It is measured using subject's dental plaque index before toothpaste and after continuous use toothpaste 3 months, calculates and use front and rear tooth
Plaque index.As a result it is as shown in table 2.
Specific dental plaque index assay method is as follows：
Facing is dried up with air gun, direct visual perception is simultaneously observed by mouth mirror, and the side that probe pinpoint is used in combination is drawn
Facing is crossed, so that it is determined that the bacterial plaque amount near facing and gum edge.
Facings of the 0=at nearly gum edge is without bacterial plaque；
1=facings at nearly gum edge have thin bacterial plaque, but are invisible to the naked eye, and only streak facing just with the side of probe pinpoint
It can find；
2=has macroscopic moderate bacterial plaque in Yin Yuan areas or tooth proximal surface；
3=is in gingival sulcus and (or) Yin Yuan areas and neighbouring facing have a large amount of soft dirts.
Each tooth be divided into buccal surface it is near in, center, it is remote neutralize 4 areas of lingual surface, score respectively.The summation of 4 score values divided by 4 it is
For the score value of the tooth, the score value of each tooth is added divided by is the individual score value by inspection tooth number.The present invention shows liquid using with bacterial plaque
(basic fuchsin) carries out plaque stain, and method makes to be extruded with the cotton pellet containing plaque disclosing agent between each two phase adjacent teeth
Plaque disclosing agent diffuses to facing, is coated with the cheek of dental pattern, lingual surface, then is gargled with clear water, is then observed, colour attaching area is
Area be present in bacterial plaque.
As a result criterion is as follows：
0=is without bacterial plaque；
There is the mottled bacterial plaque being dispersed on facing at the nearly gum edge of 1=；
Bacterial plaque thin on facing is in continuously banding at the nearly gum edge of 2=；
3=bacterial plaque colored band is wider than 1mm, but the area of coverage is less than the 1/3 of facing；
4=bacterial plaques cover facing more than 1/3, but are no more than facing 2/3；
5=bacterial plaques cover facing more than 2/3.
Table 2
There is the effect of removing bacterial plaque well by the visible toothpaste of the present invention of table 2.Use embodiment 1-3 3, toothpaste
After month, dental plaque index has and significantly reduced relative to comparative example.Confirm that embodiment toothpaste has compared to comparative example toothpaste
There is more superior antibacterial effect.
Application Example 3
Whitening effect is evaluated
Using the Isolated Tooth for having tooth stain, first manually saliva infiltrates under 37 DEG C, 100% relative humidity, then using 2g teeth
Cream, scrubbed using common soft bristle tooth brush, every time brush 1 minute, after rinsed well, dry with water, repeat abovementioned steps,
Scrub 30 times altogether.All teeth gather image in 2 weeks before scrub, after scrub by DIC respectively, and whole gatherer process enters in darkroom
OK.Machine system is debugged before operation every time, proofreaded 2 times with hawk, colored steel is proofreaded 1 time, to ensure shooting bar every time
The uniformity of part, then be placed in imaging center with standard color sample and calibrated, the state of machine is protected when gathering image every time with guarantee
Hold unanimously, colour code is removed after proof.In operating process, calibration should be repeated per hour to reduce error.By the digital picture of shooting
Input in computer, the L of corona color is determined using color analysis software GIANT*, a*, b*Value, and calculate front and rear hair of brushing teeth
Luminosity (L* values).
The whitening effect of table 3 is evaluated
Found out by table 3, after embodiment 1-3 toothpaste 3 months, tooth whitening effect evaluation number (luminosity) has
Relative to significantly improving for comparative example 1-3.Confirm that embodiment toothpaste compared to comparative example toothpaste there is more superior whitening to imitate
Fruit.
Above example only illustrates embodiment of the present invention, does not have any formal limitation to the present invention；Appoint
What is engaged in professional and technical personnel, all has the ability to make some changes or modification using the technology contents disclosed, turns into equivalent
The equivalent embodiment of change, according to the technology of the present invention essence, simple modification, equivalent change and modification is carried out to the present invention, belonged to
In the range of technical solution of the present invention.
Claims (6)
1. the multiple-effect toothpaste of a kind of mineral element containing the tremolite, it is characterised in that composed of the following components in parts by mass：12
Sodium alkyl sulfate 1-3 parts, sodium carboxymethylcellulose 0.1-0.3 parts, xanthans 0.05-0.15 parts, spices 1-2 parts, saccharin sodium
0.05-0.2 parts, glycerine 15-30 parts, methyl p-hydroxybenzoate 0.05-0.3 parts, allantoin 0.1-0.3 parts, tremolite miberal powder
10-20 parts, strontium carbonate 0.2-0.5 parts, -7 parts of silica 1, calcium carbonate 5-10 parts, glucose oxidase 0.05-0.1 parts, plant
Sour sodium 2-5 parts, calcium pyrophosphate 15-30 parts, deionized water 30-50 parts.
2. the multiple-effect toothpaste of a kind of mineral element containing the tremolite according to claim 1, it is characterised in that in parts by mass
It is composed of the following components：2 parts of lauryl sodium sulfate, 0.2 part of sodium carboxymethylcellulose, 0.1 part of xanthans, 1 part of spices, saccharin
0.1 part of sodium, 20 parts of glycerine, 0.15 part of methyl p-hydroxybenzoate, 0.2 part of allantoin, 15 parts of tremolite miberal powder, strontium carbonate 0.3
Part, 5 parts of silica, 8 parts of calcium carbonate, 0.1 part of glucose oxidase, 3 parts of sodium phytate, 22 parts of calcium pyrophosphate, deionized water 40
Part.
3. the multiple-effect toothpaste of a kind of mineral element containing the tremolite according to claim 1 or 2, it is characterised in that described
The preparation method of tremolite miberal powder is：(1) take tremolite ore deposit leftover bits and pieces to pulverize 100 mesh sieves, obtain granularity and be not more than 150 μm
Powder；(2) the powder ultramicro grinding for obtaining step (1), the powder that granularity is not more than 50 μm, as tremolite miberal powder are obtained.
4. the multiple-effect toothpaste of a kind of mineral element containing the tremolite according to claim 1 or 2, it is characterised in that described
Tremolite miberal powder includes following component：The tremolite, sodium oxide molybdena, magnesia, calcium oxide, aluminum oxide, iron oxide, potassium oxide, oxidation
Zinc, titanium dioxide, ratio of these raw materials in tremolite miberal powder are the tremolite：Sodium oxide molybdena:Magnesia:Calcium oxide:Aluminum oxide:
Iron oxide:Potassium oxide:Zinc oxide:Titanium dioxide=(800-1000)：(5-6):(60-65):(25-30):(2-2.5):(6-
8):(1-2):(0.05-0.08):(2-2.5)。
5. the multiple-effect toothpaste of a kind of mineral element containing the tremolite according to claim 1 or 2, it is characterised in that described
The preparation method of tremolite miberal powder is：(1) take tremolite ore deposit leftover bits and pieces to pulverize 100 mesh sieves, obtain granularity and be not more than 150 μm
Powder；(2) the powder ultramicro grinding for obtaining step (1), the powder that granularity is not more than 50 μm, as tremolite miberal powder are obtained.
6. the multiple-effect toothpaste of a kind of mineral element containing the tremolite according to claim 1 or 2, it is characterised in that described
The preparation method of strontium carbonate is：(1) take tremolite ore deposit leftover bits and pieces to pulverize 200 mesh sieves, obtain granularity≤0.075mm powder；
(2) powder obtained in step (1) is placed in reactor and mixed with water, uniform stirring, be slowly added to 12mol/L hydrochloric acid, add
The volume for entering hydrochloric acid is 1/10th of water, is passed through blowup, then pours out all filtrates, and saturation NaOH is added into filtrate
Solution is to filtrate in neutrality；(3) soda ash is added to neutral filtrate obtained by step (2), adds water to stir, solid-to-liquid ratio 1:1, then be passed through
Steam heats, and reacts 7h, collects precipitation；(4) precipitation in step (3) is washed repeatedly with purified water repeatedly to being in neutrality, so
It is slowly added into 50% dust technology thereto afterwards, after solution ph is adjusted to 4~5, is passed through appropriate steam, adds saturation NaOH
Solution, the pH value added to solution are 14.It is 6 that 50% dust technology regulation pH is added dropwise into this solution, is filtrated to get precipitation；(5)
Dry 24h is deposited at 180~200 DEG C by what step (4) obtained, dried precipitation is obtained into granularity≤50 through ultramicro grinding
μm SrCO3, as strontium carbonate.
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Cited By (1)
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