CN103298445A - Dentifrice composition - Google Patents
Dentifrice composition Download PDFInfo
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- CN103298445A CN103298445A CN2011800637599A CN201180063759A CN103298445A CN 103298445 A CN103298445 A CN 103298445A CN 2011800637599 A CN2011800637599 A CN 2011800637599A CN 201180063759 A CN201180063759 A CN 201180063759A CN 103298445 A CN103298445 A CN 103298445A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/60—Particulates further characterized by their structure or composition
- A61K2800/65—Characterized by the composition of the particulate/core
- A61K2800/651—The particulate/core comprising inorganic material
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- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
Provided is a dentifrice composition with which high cleaning strength is secured, which gives a sense of effective toothbrushing, feels good when used without foreign body sensations, etc., and which also has superior formability and product appearance. The dentifrice composition is characterized in containing: (A) 40-60 mass% of calcium carbonate; (B) 0.5-7 mass% of silica granules with particle diameters in the range of 53-250 [mu]m; (C) carboxymethylcellulose sodium, the viscosity at 25 DEG C of a 2 mass% aqueous solution of which is 200-600 mPa*s; and (D) carboxymethylcellulose sodium, the viscosity at 25 DEG C of a 2 mass% aqueous solution of which is 700-1500 mPa*s; wherein the mass ratio of (D)/(C) is 1.0-3.
Description
Technical field
The present invention relates to a kind of guarantee height cleaning power, the true feeling of brushing teeth excellence and do not have foreign body sensation etc., use that sense is good, the equal excellent dentifrice composition of formability and preparation outward appearance.
Background technology
Pursue the composition for oral cavity of whitening function, its decontamination is difficult to use visually-perceptible with the original pure white effect of reduction tooth, therefore think when keeping clean effect that the true feeling (true feeling of brushing teeth) of giving friction tooth when brushing teeth links together with clean effect true feeling.
Grinding agent in the composition for oral cavity is big to the clean effect contribution, generally uses calcium phosphate, calcium carbonate, abrasive silica etc., according to its amount of allocating into of different set of every kind of grinding agent cleaning power, guarantees the cleaning power to the flank of tooth thus.But the true feeling (true feeling of brushing teeth) of friction tooth in the time of can't fully obtaining to brush teeth.In addition, though the amount of allocating into of grinding agent is more many, the true feeling of brushing teeth has the tendency of raising, if increased grinding agent in order to brush teeth true feeling fully, abrasiveness increases and the possibility damage tooth.
Therefore, propose to have following technology: by uniting use calcium carbonate and settleability silicon dioxide, fatty acid amide CAB, can bring into play the true feeling of brushing teeth of appropriateness, obtain gratifying abrasive power.But can't say this technology true feeling (with reference to patent documentation 1) that obtained brushing teeth fully.In addition, as the brush teeth technology of true feeling of raising, known to inferior method: as to improve the physical force of the flank of tooth and toothbrush by allocating inorganic or organic particulate matter into, thereby obtain the true feeling of brushing teeth.But this technology true feeling of may not being brushed teeth fully sometimes in addition, if increased the amount of allocating into of granule in order to brush teeth true feeling fully, causes the problems such as sense of discomfort (with reference to patent documentation 2,3,4) that have particle rough when brushing teeth sometimes.
The prior art document
Patent documentation
Patent documentation 1: the Japan Patent spy opens the 2010-111648 communique
Patent documentation 2: the Japan Patent spy opens the 2005-68072 communique
Patent documentation 3: the Japan Patent spy opens the 2008-266251 communique
Patent documentation 4: the Japan Patent spy opens the 2004-123684 communique
Patent documentation 5: international the 2006/003989th trumpeter's volume that discloses
Summary of the invention
The present invention is mirror with above-mentioned situation, purpose be to provide a kind of guarantee height cleaning power, the true feeling of brushing teeth excellence and do not have foreign body sensation etc., use that sense is good, the equal excellent dentifrice composition of formability and preparation outward appearance.
In order to achieve the above object, the present inventor is through further investigation, found that, in containing the dentifrice composition of calcium carbonate as grinding agent, by suitably allocating specific silica dioxide granule into, can guarantee height cleaning power and the raising true feeling of brushing teeth, further use 2 kinds of different sodium carboxymethyl cellulose of viscosity by uniting, can obtain when having the excellent true feeling of brushing teeth, the formability of mastic and surface (the beautiful degree on mastic surface) be the dentifrice composition of excellence also.
The present invention is by allocating (A) calcium carbonate 40～60 quality % into, (B) in silica dioxide granule 0.5～7 quality % of particle diameter in 53～250 mu m ranges, unite use allocate into (C) 25 ℃ down 2 quality % viscosity in aqueous solution be the sodium carboxymethyl cellulose of 200～600mPas and (D) 25 ℃ down 2% viscosity in aqueous solution be 700～1, the sodium carboxymethyl cellulose of 500mPas, and the mass ratio that makes (D)/(C) is 1.0～3, a kind of colored soil removal effect of bringing into play can be provided and have excellent cleaning power, impression is less than foreign body sensation etc., the true feeling of brushing teeth improves, use sense good, formability and preparation outward appearance be the dentifrice composition of excellence all.
In addition, the applicant has proposed a kind of good dentifrice composition of sense that uses in patent documentation 5, it is water-insoluble inorganic particles such as silica dioxide granule below 100 μ m of the difference of 50～150 μ m and 90% particle diameter and mean diameter, contains following (a) and (b) water-soluble high-molecular substance of the water-soluble high-molecular substance of group, the abrasive power that has appropriateness thus with the group=0.25～3 of mass ratio (b) group/(a) by allocating ground calcium carbonate, mean diameter into.
(a) group: sodium alginate, sodium carboxymethyl cellulose, methylcellulose, hydroxyethyl-cellulose, xanthan gum, lambda-carrageenan, straight chain type sodium polyacrylate
(b) group: gellan gum, agar, kappa-carrageenan, ι-carrageenan, gelatin, pectin, cross linked sodium polyacrylate
Relative therewith, the present invention, also can guarantee height cleaning power, and have the excellent true feeling of brushing teeth even do not contain the water-soluble high-molecular substance of above-mentioned (b) group by allocating (A)～(D) composition into, use general characteristics such as sense, formability also good.Especially, the present invention has brought into play following special action effect: can improve cleaning power and the cigarette of bringing into play stain removal effect, when guaranteeing such excellence cleaning power, also have the excellent true feeling of brushing teeth, and when keeping mastic outward appearance and mouldability, can bring into play above-mentioned characteristic and good use sense.
Make the tooth this point that bleaches be difficult to use visually-perceptible with whitening with removal spots such as toothpaste, but the present composition also can be given the true feeling of brushing teeth when having clean effect, think that this is associated with clean effect true feeling.Further, even do not increase the amount of allocating into of grinding agent, also can bring into play height cleaning power, improve the true feeling of brushing teeth, therefore to not damage of tooth.
Therefore, the invention provides following dentifrice composition.
(1) a kind of dentifrice composition is characterized in that, contains:
(A) calcium carbonate 40～60 quality %,
(B) silica dioxide granule 0.5～7 quality % of particle diameter in 53～250 mu m ranges,
And contain:
(C) 25 ℃ down 2 quality % viscosity in aqueous solution be 200～600mPas sodium carboxymethyl cellulose and
(D) 25 ℃ of following 2 quality % viscosity in aqueous solution are 700～1, the sodium carboxymethyl cellulose of 500mPas,
(D)/(C) mass ratio is 1.0～3.
(2) according to (1) described dentifrice composition, it is characterized in that, contain (C) composition 0.2～0.5 quality %, (D) composition 0.3～0.8 quality %.
(3) according to (1) or (2) described dentifrice composition, it does not contain gellan gum, agar, kappa-carrageenan, ι-carrageenan, gelatin, pectin and cross linked sodium polyacrylate as water-soluble high-molecular substance.
The present invention can provide a kind of guarantee height cleaning power, the true feeling of brushing teeth excellence and do not have foreign body sensation etc., use that sense is good, the equal excellent dentifrice composition of formability and preparation outward appearance.
The specific embodiment
Below the present invention will be described in more detail.Dentifrice composition of the present invention contains: (A) 25 ℃ of calcium carbonate, (B) particle diameter silica dioxide granule, (C) in 53～250 mu m ranges down 2 quality % viscosity in aqueous solution be the sodium carboxymethyl cellulose of 200～600mPas and (D) 25 ℃ down 2% viscosity in aqueous solution be 700～1, the sodium carboxymethyl cellulose of 500mPas.
Allocate (A) calcium carbonate into as grinding agent, can effectively guarantee cleaning power and the true feeling of brushing teeth.
As calcium carbonate, its mean diameter is with 3～7 μ m, and particularly 4～6 μ m are advisable.During mean diameter less than 3 μ m, can not get cleaning fully power sometimes.When surpassing 7 μ m, abrasive power becomes excessive sometimes, can not guarantee the amount of allocating into fully, can not get the good true feeling of brushing teeth sometimes.
In addition, above-mentioned averaged particles directly is according to the measured value of little rail particle size distribution device (day machine dress Model17995-10 processed of society, Type SRA) turbidity (dV value) of detection bodies to be adjusted into 0.5 back to measure the value that obtains (under together).
As such calcium carbonate, can use the commercially available product of commodity Softone (ソ Off ト Application) 1500 grades by name that are equipped with northern efflorescence industry (strain) society system.
The amount of allocating into of calcium carbonate is 40～60% (quality %, down together) in the compositions.If allocate quantity not sufficient 40% into, then can not get cleaning fully power and the true feeling etc. of brushing teeth, if surpass 60%, sense of discomfort is arranged when then using.
(B) composition is the silica dioxide granule of particle diameter in 53～250 mu m ranges, allocates such silica dioxide granule into, foreign body sensation and sense of discomfort can not occur, can give the excellent true feeling of brushing teeth.During particle diameter less than 53 μ m, the true feeling of can not being brushed teeth fully when surpassing 250 μ m, has foreign body sensation.
As silica dioxide granule, can use gel method silicon dioxide, the precipitated silica of damp process, primary particle diameter is about 3～15nm, and preferred 4～10nm is for well.For example known have a following method etc.: pulverize after primary particle diameter in the gel method is grown into silica gel piece washing about 4～10nm, drying, be classified as the method for the silica dioxide granule of mean diameter 50～400 μ m; Thereby the spraying silica hydrosol makes the method for its gelation particle modulator in the air; After in the sedimentation method, making primary particles aggregate with fine state, it is grown to about 4～10nm, and mean diameter is adjusted into the method for 50～400 μ m the most at last, can make silica dioxide granule by these methods.Wherein, easy to the method manufacturing that the silica gel piece of modulating in the gel method is pulverized, control mean diameter easily by classification, thereby suit.Can use such method silica dioxide granule modulation, that have appropriate particle size.Can use aftermentioned testing screen (sieve) that such silica dioxide granule is classified to 53～250 μ m and obtains the silica dioxide granule of particle diameter in 53～250 mu m ranges.
As silica dioxide granule, specifically can use NIPGEL (eastern Cao's silicon chemical industry (strain) system), Sorbosil commercially available products such as (Pq Corp.'s systems).
In addition, among the present invention, except the silica dioxide granule of (B) composition, can also contain the silicon dioxide granule outside (B) composition, but (B) particle diameter of composition be 53～250 μ m silica dioxide granule contain proportional more than 95% (95～100%) of silicon dioxide granule integral body that accounts for, particularly (98～100%) are desirable more than 98%.
(B) the allocate amount of silica dioxide granule in compositions is 0.5～7%, preferred 2～5%.During less than 0.5%, can't guarantee the true feeling of brushing teeth, surpass 7%, have sense of discomfort during use.
Among the present invention, as (B) composition, particularly can not be by the silica dioxide granule (silica dioxide granules of particle diameter 53～250 μ m) of 53 μ m meshes by 250 μ m meshes in testing screen (sieve) described in the JIS Z8801-1, content is 0.5～7% in compositions, particularly 2～5% o'clock, can guarantee the true feeling of brushing teeth fully, can reach purpose of the present invention, so suit.Above-mentioned silica dioxide granule contain quantity not sufficient 0.5% time, the true feeling of can not being brushed teeth fully sometimes surpasses at 7% o'clock, and sense of discomfort is arranged sometimes.
Among the present invention, as sodium carboxymethyl cellulose, can make up allocate into (C) 25 ℃ down 2% viscosity in aqueous solution be the sodium carboxymethyl cellulose of 200～600mPas and (D) 25 ℃ down 2% viscosity in aqueous solution be 700～1, the sodium carboxymethyl cellulose of 500mPas.With these 2 kinds of sodium carboxymethyl cellulose that viscosity is different, the drug processed that obtains is when having height cleaning power, the true feeling of brushing teeth excellence by also, and the formability of mastic and surface (the beautiful degree on mastic surface) is also excellent.
In addition, above-mentioned viscosity is for passing through BH type viscometer (rotor; No. 2, rotating speed; 20rpm, minute; After 3 minutes) value measured.
(C) sodium carboxymethyl cellulose of composition 2% viscosity in aqueous solution under 25 ℃ is 200～600mPas, preferred 300～600mPas.During viscosity deficiency 200mPas, can not guarantee formability, even with (D) composition and with reaching purpose of the present invention.
(D) sodium carboxymethyl cellulose of composition 25 ℃ down 2% viscosity in aqueous solution be 700～1,500mPas, preferred 700～1,100mPas.When viscosity surpassed 1,500mPas, cream surface variation produced segmentation crack, even with (C) composition and with reaching purpose of the present invention.
The allocate amount of sodium carboxymethyl cellulose in compositions in (C) and (D) total amount of composition, is 0.5～1.3%, preferred especially 0.8～1.3%.During less than 0.5%, dentifrice composition may not become paste, surpasses at 1.3% o'clock, and it is really up to the mark to become sometimes.
In addition, in the scope of the above-mentioned amount of allocating into always, (C) the allocate amount of sodium carboxymethyl cellulose in compositions of composition preferred 0.2～0.5%, preferred especially 0.3～0.5%.(D) the allocate amount of sodium carboxymethyl cellulose in compositions of composition preferred 0.3～0.8%, preferred especially 0.5～0.8%.
(C) ratio of allocating into of composition and (D) composition in the mass ratio of composition of (D) composition/(C), is 1.0～3, preferred 1.2～2.0.When allocating into than less than 1.0, formation property variation surpasses at 3 o'clock, and mastic surface variation may produce segmentation crack.
In addition, compositions of the present invention does not contain the water-soluble high-molecular substance that is selected from gellan gum, agar, kappa-carrageenan, ι-carrageenan, gelatin, pectin, cross linked sodium polyacrylate.
Though the shape to dentifrice composition of the present invention is unrestricted, paste toothpaste agent etc. especially suits to be modulated to.At this moment, except above-mentioned constituent, can be in the scope of not damaging effect of the present invention, allocate any composition of other known compositions conducts of allocating dentifrice composition usually into into, grinding agent, adhesion agent, binding agent, surfactant, the wetting agent outside (A) composition for example, also can allocate appropriate ingredients such as sweeting agent, coloring agent, antiseptic, preserving stabilizer, pH regulator agent, effective ingredient as required into, these compositions can be mixed by usual way with water and make.
As grinding agent, except the calcium carbonate of (A) composition, can allocate other grinding agent into.Particularly, in the scope of not damaging effect of the present invention, can also allocate into as dicalcium phosphate dihydrate, calcium hydrogen phosphate is anhydrous and thing, calcium pyrophosphate, aluminium hydroxide, aluminium oxide, titanium dioxide, polymethyl methacrylate, insoluble methyl acid phosphate calcium, magnesium carbonate, tricresyl phosphate magnesium, zeolite, Zirconium orthosilicate., hydroxyapatite, fluor-apatite, calcium phosphorus deficiency lime stone, tricalcium phosphate, tetracalcium phosphate, OCP etc.Can be with the control of the amount of allocating into of these grinding agents in 40～60% scope of the composition in its entirety of the calcium carbonate that comprises (A) composition.
As surfactant, can enumerate anionic surfactant, amphoteric surfactant, nonionic surfactant etc.For example; as the anionic surfactant, can enumerate lauryl sulfate, Semen Myristicae sulfate, laureth sulfate, N-lauroyl taurate, Hamposyl L salt, alpha-alkene sulfonate etc., as salt; consider from aspects such as dissolubilities, be advisable with sodium salt.As amphoteric surfactant; for example can enumerate N-acyl glutamate, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazole betanin, fatty acid amide CAB etc.; from the dissolubility aspect, the chain length of preferred fatty acid is the amphoteric surfactant of carbon number 12～14.As nonionic surfactant, for example can enumerate polyoxyethylene alkyl ether, alkyl glucoside, sucrose fatty acid ester, alkanolamide, polyoxyethylene 20 sorbitan monostearate, polyoxyethylene polyoxypropylene glycol, fatty acid polyglycol glycerol, polyoxyethylene hardened castor oil etc.
In addition, the amount of allocating into of these surfactants is generally 0.5～5% of composition in its entirety, and preferred 0.8～3%.
As adhesion agent, for example also can allocate polyhydric alcohol such as Sorbitol, glycerol, ethylene glycol, propylene glycol, 1,3 butylene glycol, Polyethylene Glycol, polypropylene glycol, xylitol, maltose alcohol, erithritol or sugar alcohol etc. into.The amount of allocating into of adhesion agent is generally 10～30%, and preferred 20～30%.
In the scope of not damaging effect of the present invention, for example also can allocate non-anionic property binding agent such as hydroxymethyl-propyl cellulose into as binding agent, but its amount of allocating into is preferably below 0.5%.
As effective ingredient, can enumerate sodium fluoride, potassium fluoride, stannous fluoride, strontium fluoride, fluorides such as sodium monofluorophosphate, hibitane, triclosan, isopropyl methyl phenol, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, the hibitane salt, sorbate, the Chinese juniper another name for, antibiotic property materials such as azulene sulfonate, glucanase, dextranase (Mutanase), proteolytic enzyme, catabolic enzymes such as lysozyme, tranexamic acid, episilon amino caproic acid, allantoin, glycyrrhizic acid, anti-inflammatory substance such as enoxolone, sodium chloride, potassium nitrate, aluctyl., zinc chloride, zinc citrate, inorganic salts such as strontium chloride, sodium tripolyphosphate, tetrasodium pyrophosphate, zeolite, chlorophyll copper sodium, chlorophyll, chelating chemical compounds such as glycerophosphate, ascorbic acid, tocopheryl acetate, various vitaminss such as pyridoxol, the soft extract of east angelica root, Cortex Phellodendri extract, Flos Matricariae chamomillae, Flos Caryophylli, Herba Rosmarini Officinalis, Radix Scutellariae, natural extracts such as Flos Carthami etc.In the scope of not damaging effect of the present invention, the amount of allocating into of these effective ingredient can be set at effective dose.
In addition, as sweeting agent, can enumerate saccharin sodium, aspartame, stevioside, Flos Chrysanthemi extractum, p-met hoxycinnamic aldehyde, neohesperidin dihydrochalcone, perillartine (Peryllartine) etc.As antiseptic, can enumerate Nipagin ester such as butyl p-hydroxybenzoate, ethylparaben (p-Hydroxybenzoate), sodium benzoate etc.
As coloring agent, can enumerate red No. 2, red No. 3, red No. 225, red No. 226, yellow No. 4, yellow No. 5, yellow No. 205, blue No. 1, blue No. 2, blue No. 201, blue No. 204, green No. 3, mica titanium, titanium oxide etc.
As antiseptic, can enumerate p-Hydroxybenzoate, sodium benzoate etc.
As the pH regulator agent, for example can enumerate various salt, sodium hydroxide of citric acid, malic acid, lactic acid, tartaric acid, acetic acid, phosphoric acid, pyrophosphoric acid, phosphoglycerol and these acid etc.In addition, preferably the pH regulator with dentifrice composition of the present invention is 6～10, especially preferably is adjusted to 7～9.
Spice can use the known spice material for dentifrice composition, Oleum menthae for example, Oleum Menthae Rotundifoliae, oleum anisi, eucalyptus oil, wintergreen oil, Oleum Cinnamomi, Oleum Caryophylli, Oleum thymi vulgaris, sage oil, Fructus Citri Limoniae oil, orange-seed oil, Oleum menthae, Cardamom oil, Fructus Coriandri oil, Oleum Citri tangerinae, lime oil, Oleum lavandula angustifolia, oil of rosemary, laurel fat, chamomile oil, caraway oil, Majorana hortensis oil, laurel, lemongrass oil, Herba Origani oil, pinke needle oil, orange blossom oil, attar of roses, Jasmin oil, flag flower extractum, the Herba Menthae quintessence oil, the Flos Rosae Multiflorae quintessence oil, natural perfume materials such as orange blossom, and these natural perfume material processed (as are removed anterior fraction, remove tailings, fractional distillation, liquid-liquid extraction, rectificationization, powder perfumeization etc.) spice that obtains after, and menthol, carvone, anethole, cineole, methyl salicylate, cinnamic aldehyde, eugenol, 3-1-Herba Menthae oxygen base the third-1, the 2-glycol, thymol, linalool, linalyl-acetate, limonene, menthone, menthyl acetate, the N-replacement-to terpane-3-Methanamide, sobrerone, octanal, citral, pulegone, carvacryl acetate, anisaldehyde, ethyl acetate, ethyl n-butyrate., allyl cyclohexyl propionate, methyl 2-aminobenzoate, methyl phenyl ethyl glycidate, vanillin, undecalactone, hexanal, ethanol, propanol, butanols, isoamyl alcohol, hexenol, dimethyl sulfide, methyl cyclopentenyl ketone, furfural, trimethylpyrazine, ethyl lactate, methyl lactate, simple spice such as ethyl thioacetate, also has Fructus Fragariae Ananssae perfume (or spice), Fructus Mali pumilae perfume (or spice), banana incense, Fructus Ananadis comosi perfume (or spice), Fructus Vitis viniferae perfume (or spice), Fructus Mangifera Indicae perfume (or spice), butter perfume (or spice), milk, fruit mixes fragrant, potpourris such as tropical fruit (tree) perfume (or spice) etc. are not limited to the spice of embodiment.
In addition, though the amount of allocating into also is not particularly limited, preferably in forming, preparation uses 0.000001～1% above-mentioned spice material.In addition, as the fragrant spice of using of the tax of having used above-mentioned spice material, preferably use 0.1～2.0% at dentifrice composition.
The container material of holding dentifrice composition is not particularly limited, can uses the container for dentifrice composition usually.Specifically can use plastic containers such as polyethylene, polypropylene, polyethylene terephthalate, nylon etc.
Embodiment
Specify the present invention below by embodiment and comparative example, but the present invention is not subjected to the restriction of following embodiment.In addition, when not specifying in the following example, % represents quality %.In addition, the particle diameter of each composition, viscosity etc. are to use with above-mentioned same assay method and measure the value that obtains.
(embodiment, comparative example)
Dentifrice composition by forming shown in common method preparation table 1～3 uses following method evaluation.The result is shown in table 1～3.
The evaluation methodology that＜cleaning power is estimated 〉
The manufacture method of adhering to the hydroapatite particles of cigarette stain
Behind the pouncing paper grinding hydroapatite particles surface (Bin De society system, diameter 7mm * thickness 3.5mm) with #100, in sonic washing machine, pass through the neutral detergent solution washing.Etched surfaces in 30% phosphate aqueous solution (10 minutes), washing behind the natural drying, are measured the Lab value (L0) of adhering to the preceding granule of cigarette stain.Place metal tray at the glass table, with hydroapatite particles side by side, cover dryer door.In exsiccator upper part of the cover rubber bolt, insert two glass tubings, insert cigarette in the glass tubing.Another root glass tubing links to each other with air exhauster, introduces current, after opening water tap and beginning suction, cigarette is lighted, and makes the cigarette that is full of cigarette in the exsiccator.Cigarette soon the moment of after-flame close water tap stop the suction, placed 3 minutes, the cigarette natural subsidence is adhered at hydroapatite particles.Repeat this operation 10 times, 10 cigarettes are adhered in this wise.150 ℃ of following sintering 4 hours are made the hydroapatite particles that adheres to the cigarette stain.The surface color of the granule that mensuration is made should be worth as L1.
Tobacco dirty remover Evaluation on effect method
With the ion exchange water dilution of dentifrice composition with 3 times of amounts, make the toothpaste dispersion liquid.To be immersed in the toothpaste dispersion liquid with the hydroapatite particles that adheres to the cigarette stain that said method is made, with horizontal brush type toothbrush (trade name PC Clinica is housed, lion king (strain) system) automatic grinding testing machine (increasing the weight of 250g) brush 200 times, the Lab value (L2) of the granule behind the mensuration brush.Calculate cigarette stain clearance by following formula, according to this cigarette stain clearance of following benchmark evaluation.
Cigarette stain clearance (%)=((L1-L2)/(L1-L0)) * 100
The metewand of cleaning power (tobacco dirty remover effect)
◎: cigarette stain clearance is more than 50%
Zero: cigarette stain clearance is more than 40% and less than 50%
△: cigarette stain clearance is more than 30% and less than 40%
*: cigarette stain clearance less than 30%
The evaluation methodology of＜the true feeling of brushing teeth 〉
Subject 10 people squeeze the dentifrice composition of about 1g at the toothbrush of brush head breadth 10mm, long 20mm, and the true feeling of brushing teeth when brushing teeth is carried out the answer of 4 levels.During this was answered, " feel good cleaning sense " was that 4 minutes, " feel cleaning sense " are that 3 minutes, " how not feel cleaning sense " are 2 minutes, and " do not feel cleaning feel " is 1 minute, by following benchmark by 10 people's the average mark evaluation true feeling of brushing teeth.
◎: average mark is more than 3.5 minutes below 4.0 minutes
Zero: average mark is more than 3.0 minutes and less than 3.5 minutes
△: average mark is more than 2.0 minutes and less than 3.0 minutes
*: average mark is more than 1.0 minutes and less than 2.0 minutes
The evaluation methodology of＜foreign body sensation 〉
Subject 10 people squeeze the dentifrice composition of about 1g at the toothbrush of brush head breadth 10mm, long 20mm, and the rough foreign body sensation of granule carries out the answer of 4 levels when brushing teeth.During this was answered, " not feeling foreign body sensation " was that 4 minutes, " almost not feeling foreign body sensation " are that 3 minutes, " feel a little foreign body sensation " are that 2 minutes, " feeling foreign body sensation " are 1 minute, estimates rough foreign body sensation by following benchmark by 10 people's average mark.
◎: average mark is more than 3.5 minutes below 4.0 minutes
Zero: average mark is more than 3.0 minutes and less than 3.5 minutes
△: average mark is more than 2.0 minutes and less than 3.0 minutes
*: average mark is more than 1.0 minutes and less than 2.0 minutes
The evaluation methodology of＜sense of discomfort 〉
Subject 10 people squeeze the dentifrice composition of about 1g at the toothbrush of brush head breadth 10mm, long 20mm, and rough sense of discomfort is carried out the answer of 4 levels when brushing teeth.During this was answered, " not feeling well " was that 4 minutes, " almost not feeling well " are that 3 minutes, " feel a little sense of discomfort " are that 2 minutes, " not feeling well " are 1 minute, presses following benchmark by 10 people's the rough sense of discomfort of average mark evaluation.
◎: average mark is more than 3.5 minutes below 4.0 minutes
Zero: average mark is more than 3.0 minutes and less than 3.5 minutes
△: average mark is more than 2.0 minutes and less than 3.0 minutes
*: average mark is more than 1.0 minutes and less than 2.0 minutes
The evaluation methodology on＜mastic surface 〉
In laminated tube, fill the 50g dentifrice composition, extrude 15cm at rag paper, by visual observations toothpaste agent surface tarnish is arranged, can observe fold, this is carried out the evaluation of 4 levels.Wherein, " toothpaste agent surface is glossy; do not observe fold " is that 4 minutes, " there is a little gloss on toothpaste agent surface; do not have fold " are that 3 minutes, " toothpaste agent surface is almost matt; observe fold " are that 2 minutes, " toothpaste agent mattness; observe fold " are 1 minute, and the meansigma methods of estimating for 5 times is judged with 4 levels by following benchmark.
◎: more than 3.5 minutes below 4.0 minutes
More than zero: 3.0 minute and less than 3.5 minutes
△: more than 2.0 minutes and less than 3.0 minutes
*: less than 2.0 minutes
The evaluation methodology of＜formability 〉
In laminated tube, fill the 50g dentifrice composition, dentifrice composition is extruded 1.5g to toothbrush from laminated tube, to this moment change of shape on toothbrush carry out the evaluation of 4 levels, " do not observe distortion " and be 4 fens, " though observe some distortion use go up no problem " be that 3 minutes, " gently distortion " are that 2 minutes, " distortion at once " are 1 minute, the meansigma methods of estimating for 5 times is carried out the judgement of 4 levels by following benchmark.
◎: more than 3.5 minutes below 4.0 minutes
More than zero: 3.0 minute and less than 3.5 minutes
△: more than 2.0 minutes and less than 3.0 minutes
*: less than 2.0 minutes
Table 1
Table 2
Table 3
In addition, raw materials used details is as described below.
(A) calcium carbonate: be equipped with northern efflorescence industry (strain) system, trade name Soften1500, mean diameter 4.5 μ m
(B) silica dioxide granule
Silica dioxide granule B1: eastern Cao's silication (strain) system, trade name NIPGEL
With sieve classification AY level, collection cut size is the silica dioxide granule in 53～250 mu m ranges.Mean diameter is 80 μ m.
Silica dioxide granule B2: eastern Cao's silication (strain) system, trade name NIPGEL
With sieve classification AY level (with above-mentioned silica dioxide granule B1 batch different commodity), collection cut size is the silica dioxide granule in 53～250 mu m ranges.Mean diameter is 100 μ m.
Silica dioxide granule B3 (relatively thing): eastern Cao's silication (strain) system, trade name NIPGEL
With sieve classification AY level, collection cut size is the silica dioxide granule in 251～710 mu m ranges.Mean diameter is 450 μ m.
Silica dioxide granule B4 (relatively thing): eastern Cao's silication (strain) system, NIPGEL
With sieve classification AY level, the silica dioxide granule of collection cut size less than 53 μ m.Mean diameter is 30 μ m.
(C) sodium carboxymethyl cellulose
Sodium carboxymethyl cellulose C1:25 ℃, 2% solution viscosity 451mPas, trade name CMC Daicel, Daicel chemical industry (strain) system
Sodium carboxymethyl cellulose C2:25 ℃, 2% solution viscosity 510mPas, trade name CMC Daicel, Daicel chemical industry (strain) system
Sodium carboxymethyl cellulose C3:25 ℃, 2% solution viscosity 500mPas, trade name CMC Daicel, Daicel chemical industry (strain) system
Sodium carboxymethyl cellulose C4 (relatively thing): 25 ℃, 2% solution viscosity 121mPas, trade name CMC Daicel, Daicel chemical industry (strain) system
(D) sodium carboxymethyl cellulose
Sodium carboxymethyl cellulose D1:25 ℃, 2% solution viscosity 950mPas, trade name CMC Daicel, Daicel chemical industry (strain) system
Sodium carboxymethyl cellulose D2:25 ℃, 2% solution viscosity 1,020mPas, trade name CMC Daicel, Daicel chemical industry (strain) system
Sodium carboxymethyl cellulose D3:25 ℃, 2% solution viscosity 853mPas, CMC Daicel, Daicel chemical industry (strain) system
Sodium carboxymethyl cellulose D4 (relatively thing): 25 ℃, 2% solution viscosity 1,975mPas, trade name CMC Daicel, Daicel chemical industry (strain) system
Claims (3)
1. a dentifrice composition is characterized in that, contains:
(A) calcium carbonate 40～60 quality %,
(B) particle diameter is at silica dioxide granule 0.5～7 quality % of 53～250 mu m ranges,
And contain:
(C) 25 ℃ down 2 quality % viscosity in aqueous solution be 200～600mPas sodium carboxymethyl cellulose and
(D) 25 ℃ of following 2 quality % viscosity in aqueous solution are 700～1, the sodium carboxymethyl cellulose of 500mPas,
(D)/(C) mass ratio is 1.0～3.
2. dentifrice composition according to claim 1 is characterized in that, contains (C) composition 0.2～0.5 quality %, (D) composition 0.3～0.8 quality %.
3. dentifrice composition according to claim 1 and 2, it does not contain gellan gum, agar, kappa-carrageenan, ι-carrageenan, gelatin, pectin and cross linked sodium polyacrylate as water-soluble high-molecular substance.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010289736 | 2010-12-27 | ||
| JP2010-289736 | 2010-12-27 | ||
| PCT/JP2011/073288 WO2012090571A1 (en) | 2010-12-27 | 2011-10-11 | Dentrifice composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103298445A true CN103298445A (en) | 2013-09-11 |
| CN103298445B CN103298445B (en) | 2015-07-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201180063759.9A Active CN103298445B (en) | 2010-12-27 | 2011-10-11 | Dentifrice composition |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP5907075B2 (en) |
| CN (1) | CN103298445B (en) |
| WO (1) | WO2012090571A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105769705A (en) * | 2016-04-23 | 2016-07-20 | 李大兴 | Mulberry leaf and mulberry fruit antibacterial toothpaste |
| CN111511356A (en) * | 2017-12-26 | 2020-08-07 | 狮王株式会社 | Adhesive patch and method for producing same |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7376976B2 (en) * | 2017-12-26 | 2023-11-09 | 小林製薬株式会社 | Oral composition for deodorizing tobacco odor |
| JP7117844B2 (en) * | 2017-12-26 | 2022-08-15 | 小林製薬株式会社 | oral composition |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56152414A (en) * | 1980-04-24 | 1981-11-26 | Sunstar Inc | Toothpaste composition |
| JP2002047159A (en) * | 2000-07-31 | 2002-02-12 | Sunstar Inc | Dentifrice composition |
| CN1988876A (en) * | 2004-07-06 | 2007-06-27 | 狮王株式会社 | Dentifrice composition |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0617297B2 (en) * | 1986-10-27 | 1994-03-09 | 花王株式会社 | Toothpaste composition |
| JP3108019B2 (en) * | 1996-07-11 | 2000-11-13 | 第一工業製薬株式会社 | Toothpaste binder and toothpaste using the same |
-
2011
- 2011-10-11 WO PCT/JP2011/073288 patent/WO2012090571A1/en active Application Filing
- 2011-10-11 JP JP2012550760A patent/JP5907075B2/en active Active
- 2011-10-11 CN CN201180063759.9A patent/CN103298445B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56152414A (en) * | 1980-04-24 | 1981-11-26 | Sunstar Inc | Toothpaste composition |
| JP2002047159A (en) * | 2000-07-31 | 2002-02-12 | Sunstar Inc | Dentifrice composition |
| CN1988876A (en) * | 2004-07-06 | 2007-06-27 | 狮王株式会社 | Dentifrice composition |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105769705A (en) * | 2016-04-23 | 2016-07-20 | 李大兴 | Mulberry leaf and mulberry fruit antibacterial toothpaste |
| CN111511356A (en) * | 2017-12-26 | 2020-08-07 | 狮王株式会社 | Adhesive patch and method for producing same |
| CN111511356B (en) * | 2017-12-26 | 2024-05-28 | 狮王株式会社 | Patch and method for producing same |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012090571A1 (en) | 2012-07-05 |
| JP5907075B2 (en) | 2016-04-20 |
| CN103298445B (en) | 2015-07-22 |
| JPWO2012090571A1 (en) | 2014-06-05 |
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