JP6665706B2 - Tooth whitening composition and tooth whitening set - Google Patents

Description

  TECHNICAL FIELD The present invention relates to a tooth whitening composition and a tooth whitening set which are excellent in tooth whitening effect and stain removal effect of removing coloring matter accumulated on the surface of a tooth, and are effective for whitening teeth.

  There is a high need for consumers to whiten their teeth. As a technique for making the teeth whiter than the original teeth, there is a bleaching technique using a peroxide such as hydrogen peroxide or urea peroxide. However, they are performed under the control of a dentist with specialized knowledge and skills, and there is a high risk of harm, such as the appearance of hyperesthesia. There is also a technique for whitening by manicure of teeth. However, there is a problem that a coating agent used is peeled off by eating or drinking.

  Therefore, as a technique to easily and safely whiten teeth by themselves without having special expertise and expertise, applicants can penetrate liquids such as polyethylene glycol under the enamel surface layer, A technique has been proposed in which the teeth look white by changing the refractive index (Patent Documents 1 and 2). In addition, a technique has been proposed in which a tooth looks white by containing polyglycerin and a thickener in a specific ratio (Patent Document 3).

Japanese Patent No. 447084 Japanese Patent No. 4462428 Japanese Patent No. 4656324

  However, there is still room for improvement in the whitening time and whitening effect of the above-mentioned technology, and a technology for effectively whitening the tooth by further improvement has been desired.

  The present invention has been made in view of the above circumstances, and has an excellent tooth whitening effect and a stain removing effect of removing a coloring matter accumulated on the surface of a tooth, and is effective for whitening teeth. It is intended to provide a set for use.

The present inventors have conducted intensive studies to achieve the above object, and as a result, (A) one or more polyhydric alcohols selected from 1,3-butylene glycol and polyethylene glycol having an average molecular weight of 380 to 630. Is mixed with a specific amount or more, (B) condensed phosphate, and (C) water with a specific amount or less, and the mass ratio of (B) / (C) is set to a specific value or less, thereby whitening teeth. The effect and the stain removal effect of removing colored stains accumulated on the surface of the teeth are excellent, and the stimulation is suppressed, and the feeling of use is good, and it is found that a composition for tooth whitening that is effective for whitening teeth can be obtained. Thus, the present invention has been accomplished.
Further, the present inventors, the tooth whitening composition, while holding this composition, applied by contacting the teeth, and a tooth whitening set provided with an application tool that is detachably attached, the tooth whitening set, It has also been found that a tooth whitening effect and a stain removing effect can be more effectively imparted.

To a tooth whitening composition containing a polyhydric alcohol having a tooth whitening effect, a condensed phosphate having a stain removing effect is compounded, and a tooth whitening effect by the polyhydric alcohol and a stain removing effect by the condensed phosphate are contained. It is difficult to simultaneously and satisfactorily express and, as shown in a comparative example below, when an inappropriate polyhydric alcohol and a condensed phosphate are used in combination, the whitening effect is reduced, and addition of water If the amount is not appropriate, there arises a problem that the whitening effect and the stain removing effect cannot be sufficiently exhibited, but in the present invention, when the components (A), (B), and (C) are combined, ( When the amount of the component (C) is equal to or less than the specific value and the mass ratio of (B) / (C) is equal to or less than the specific value, both the excellent tooth whitening effect and the stain removing effect can be achieved without causing the above-described problem. Case The Do action and effect can be imparted.
According to the present invention, an excellent whitening effect of whitening teeth and a high stain removal effect at the same time without using peroxide are provided, and further improving the whitening effect of teeth by combining both effects, teeth are provided. It can be expected that a satisfactory effect realization of whitening and beautiful whitening is imparted, and simple and safe tooth whitening becomes possible.

Therefore, the present invention
(A) 70% by mass or more of one or more polyhydric alcohols selected from 1,3-butylene glycol and polyethylene glycol having an average molecular weight of 380 to 630,
(B) a composition for tooth whitening, which contains 15% by mass or less of a condensed phosphate and water (C) and a mass ratio of (B) / (C) is 0.18 or less, and A tooth whitening set, comprising: the tooth whitening composition; and an application tool that holds the composition and applies the tooth to the tooth and detachably attaches the tooth whitening composition.

  ADVANTAGE OF THE INVENTION According to this invention, the tooth whitening composition and the set for teeth whitening which are excellent in the tooth whitening effect and the stain removal effect which removes the coloring matter accumulated on the tooth surface, and are effective for the whitening of the tooth can be provided. According to the present invention, it is possible to whiten teeth satisfactorily, easily, and safely without having special technical knowledge and technical skills.

  Hereinafter, the present invention will be described in more detail. The tooth whitening composition of the present invention comprises (A) one or two kinds selected from 1,3 butylene glycol and polyethylene glycol having an average molecular weight of 380 to 630 as a tooth whitening component. It contains the above polyhydric alcohol, (B) a condensed phosphate as a stain removing component, and (C) water. In the present invention, a composition containing a whitening component is prepared in the form of a liquid, a paste, a gel, or the like, and is used in contact with the surface of a tooth. It is preferable to use it as a tooth whitening set together with a special application tool that is securely applied, held, fixed, and detachably attached to a tooth.

The component (A) is a tooth whitening component, and is one or more polyhydric alcohols selected from 1,3-butylene glycol and polyethylene glycol having an average molecular weight of 380 to 630, preferably 1,3-butyl alcohol. Butylene glycol.
The polyhydric alcohol of the component (A) penetrates beneath the surface layer of the enamel and replaces the moisture in the enamel crystal to change the refractive index of light, so that the enamel appears cloudy and white. The composition of the present invention can whiten teeth without containing a peroxide such as hydrogen peroxide, and has high safety. In addition, after whitening, it is a reversible whitening effect in which the whitening component that has permeated into the enamel is replaced by moisture again by saliva in a few hours and returns to the original tooth color. .

As 1,3-butylene glycol, a commercially available product that can be used in the oral cavity can be used. For example, those manufactured by Daicel Corporation can be used.
Further, commercially available polyethylene glycol having an average molecular weight of 380 to 630 can be used. The average molecular weight indicates an average molecular weight described in quasi-drug raw material standards 2006 (the same applies hereinafter). Specifically, polyethylene glycol 400 (average molecular weight 380 to 420) and polyethylene glycol 600 (average molecular weight 570 to 630) can be exemplified. Note that, depending on the product, # may appear between polyethylene glycol and a numerical value, for example, polyethylene glycol # 400. As such polyethylene glycol, for example, those manufactured by Lion Specialty Chemicals Co., Ltd. or Daiichi Kogyo Seiyaku Co., Ltd. can be used.

  The content of the polyhydric alcohol as the component (A) is at least 70% (mass%, hereinafter the same) of the whole composition, preferably 70 to 95%, more preferably 75 to 90%, and still more preferably 80%. ~ 90%. If the content is less than 70%, a sufficient whitening effect cannot be obtained. A content of 95% or less is suitable for maintaining the stain removing effect and suppressing irritation. If the content is too large, the stain removal effect may be poor or the irritation may be strong.

  In the present invention, further, as the polyhydric alcohol other than the component (A), in particular, polyethylene glycol having an average molecular weight of less than 380, particularly 320 or less, specifically, polyethylene glycol 200 (average molecular weight of 190 to 210), polyethylene Glycol 300 (average molecular weight: 280 to 320) may be added in a range that does not impair the effects of the present invention, but it is preferable not to add too much in order to sufficiently maintain the whitening effect. More preferred. The amount of these additives is preferably 15% or less, particularly 0 to 12%, more preferably 0% with no addition, based on the whole composition.

(B) The condensed phosphate is a stain removing component, and improves the whitening effect by removing colored stains accumulated on the tooth surface. In particular, in the present invention, the stain removal effect of the condensed phosphate (B) is based on the effect that the polyphosphate dissolves, polishes, or decolorizes the stain from the surface layer. , And a high removal effect is exerted by a chemical action by weakening the bond between the stain and the enamel and detaching the stain from the tooth surface layer.
Examples of the condensed phosphate include sodium and potassium linear polyphosphates such as pyrophosphoric acid, tripolyphosphoric acid and tetrapolyphosphoric acid, and sodium and potassium salts of cyclic polyphosphoric acids such as trimetaphosphoric acid and tetrametaphosphoric acid. And one or more of these may be used. Particularly, a linear polyphosphate is preferable, and among them, sodium tripolyphosphate and sodium pyrophosphate are preferable, and sodium tripolyphosphate is most preferable.
As the condensed phosphate of the component (B), commercially available ones can be used, and examples thereof include those manufactured by Taihei Chemical Industry Co., Ltd.

  (B) The content of the condensed phosphate is preferably from 0.1 to 3%, more preferably from 0.3 to 2.5%, particularly preferably from 0.5 to 2% of the whole composition. As the content increases, the stain removing effect increases, but when the content is not too high, the irritation is suppressed and the feeling of use can be maintained well. If it exceeds 3%, the stimulus to the oral cavity may be high and the feeling in use may be poor.

  (C) Commercially available water can be used. (C) The content of water is 15% or less of the whole composition, preferably 1 to 15%, and more preferably 3 to 10%. If the content exceeds 15%, the whitening effect cannot be obtained. When the content is 1% or more, the component (B) has a sufficient stain removing effect, and the irritation is sufficiently suppressed.

  In the present invention, (B) / (C) indicating the blending ratio of the component (B) and the component (C) is 0.18 or less by mass, preferably 0.01 to 0.18, More preferably, it is 0.02 to 0.15. When (B) / (C) exceeds 0.18, the stain removing effect of the component (B) is inferior, and the stimulus of the component (B) is strongly expressed and the stimulus at the time of use becomes strong, so that the feeling of use becomes poor. Inferior. Furthermore, when the proportion of the component (B) is increased, the component (B) is hardly dissolved, which may adversely affect the appearance and stability of the preparation. If (B) / (C) is less than 0.01, the stain removal effect may not be sufficiently obtained.

  In the present invention, for example, a thickener can be used for the purpose of increasing the viscosity of the composition, or gelling or pasting to improve the applicability to teeth and the adhesion to teeth. The thickener may be any as long as it can adjust the viscosity of the composition according to the method of use and can be used for oral preparations. For example, hydroxypropylcellulose, hydroxypropylmethylcellulose, sodium hydroxyethylcellulose, cellulose derivatives such as sodium carboxymethylcellulose, xanthan gum, polyvinylpyrrolidone, carrageenan, methylcellulose, sodium alginate, tragacanth gum, karaya gum, arabia gum, locust bean gum, polyvinyl alcohol, polyacrylic acid Organic thickeners such as sodium, cross-linked sodium polyacrylate, carboxyvinyl polymer, carbopol, veegum, propylene glycol alginate, agar, gelatin, starch, glucomannan, and inorganic thickeners such as thickening silica and aluminum silicate And these may be used alone or in combination of two or more. Preferred thickeners are cellulose derivatives having a hydroxy group, and particularly preferred are hydroxypropylcellulose and hydroxypropylmethylcellulose. When such a thickener is added, the whitening effect and the stain removing effect are further improved. The addition amount of the thickener is desirably 0 to 5% of the whole composition, and when added, it is desirably 0.2% or more.

  In the tooth whitening composition of the present invention, in addition to the above components, other known components that can be blended in the oral preparation can be blended according to the purpose of use, dosage form, etc., as long as the effects of the present invention are not impaired. . For example, cleaning agents, surfactants, wetting agents, sweeteners, preservatives, pH adjusters, flavors, medicinal ingredients and the like can be mentioned.

As the cleaning agent, water-insoluble powders or granules are preferable.
Examples of the powder include silica-based compounds such as silica gel, precipitated silica and zirconosilicate, phosphate-based compounds such as dibasic calcium phosphate dihydrate, dibasic calcium phosphate anhydrate and calcium pyrophosphate, and polymethyl methacrylate. And insoluble calcium metaphosphate, light calcium carbonate, heavy calcium carbonate, magnesium carbonate, tertiary magnesium phosphate, zirconium silicate, hydroxyapatite, and synthetic resin compounds.

The granules were formed by granulating a water-insoluble powder into granules, granules obtained by granulating a water-insoluble powder with a water-insoluble inorganic binder, and granulating a water-insoluble powder by a water-insoluble organic binder. Granules can be used, and granules obtained by forming a water-insoluble powder into granules are particularly preferable.
Specifically, silica-based particles such as silicic anhydride, hydrous silicic acid, titanium silicate, and zirconium silicate, and inorganic compounds such as zeolite, calcium phosphate, calcium pyrophosphate, calcium carbonate, aluminum hydroxide, aluminum oxide, and titanium oxide Or granules of these components, natural polymers such as agar, gelatin, starch, and glucomannan; and granules composed of synthetic polymers such as acrylic, polyurethane, polyester, polyamide, nylon, and polyvinyl chloride, or these components. Granules obtained by mixing can be used.

As the silica granules, gel silica of a wet method and precipitated silica are suitably used, and the primary particle diameter is about 3 to 15 nm, preferably 4 to 10 nm. For example, a method in which a lump of silica gel having a primary particle diameter grown to about 4 to 10 nm by a gel method is washed, dried, and then pulverized and classified into silica granules having an average particle diameter of 50 to 400 μm. A method of preparing granules by spraying in air and gelling, or a method of preparing particles by agglomerating while suppressing the growth of primary particles by sedimentation method and then growing the primary particle diameter to about 4 to 10 nm, etc. It is known and silica granules can be prepared by these methods. Among them, a method of pulverizing a lump of silica gel prepared by a gel method is preferable because it is simple in production and the average particle size can be easily controlled by classification. By preparing by such a method, granules having an appropriate average disintegration strength can be obtained.
As such granules, commercially available products can be used. Specifically, as silica granules, SORBOSIL BFG10, SORBOSIL BFG50 of PQ Corporation, NIPGEL AY-001, BY-001, CY-001, CY-001 of Tosoh Silica, and HUBER of HUBER Granules such as Zeodent 9175, but not limited thereto.
The cleaning agent can be blended alone or in combination of two or more, and the blending amount is preferably 0 to 5% of the whole composition.

As the surfactant, an anionic surfactant, an amphoteric surfactant, a nonionic surfactant, and a cationic surfactant can be used alone or in combination of two or more.
Examples of the anionic surfactant include alkyl sulfates such as sodium lauryl sulfate, sodium dodecylbenzenesulfonate, sodium hydrogenated coconut fatty acid monoglyceride monosulfate, sodium lauryl sulfoacetate, sodium α-olefin sulfonate, N-methyl-N- N-acyl tauric acid salts such as sodium acyltaurine; amino acid-based surfactants such as sodium N-acyl-L-glutamate; sodium acylsarcosine;
Examples of the amphoteric surfactant include an amidopropyl betaine-type amphoteric surfactant, a betaine acetate-type amphoteric surfactant, an imidazoline-type amphoteric surfactant, and an amine oxide-type amphoteric surfactant.
Examples of nonionic surfactants include sucrose fatty acid esters such as polyoxyethylene hydrogenated castor oil, polyglycerin fatty acid ester, sucrose fatty acid ester, and maltose fatty acid ester; sugar alcohol fatty acid esters such as maltitol fatty acid ester and lactol fatty acid ester. , Alkylol amide, polyoxyethylene sorbitan fatty acid ester such as polyoxyethylene sorbitan monostearate, fatty acid diethanolamide such as lauric acid mono- or diethanolamide, sorbitan fatty acid ester, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxypropylene Copolymers, polyoxyethylene polyoxypropylene fatty acid esters, pluronics and the like can be mentioned.
Examples of the cationic surfactant include an alkyl ammonium, an alkyl benzyl ammonium salt and the like.
The amount of these surfactants is preferably 0 to 1% of the whole composition.

  Examples of the humectant include polyhydric alcohols and sugar alcohols other than the component (A), such as sorbitol, erythritol, reduced starch saccharified product, glycerin, and propylene glycol. These can be used alone or in combination of two or more. The compounding amount is preferably 0 to 5% of the whole composition.

Examples of the sweetener include saccharin sodium, stevioside, stevia extract, paramethoxycinamic aldehyde, neohesperidyl dihydrochalcone, perlartin, glycyrrhizin, thaumatin, asparatyl phenylalanine methyl ester, acesulfame K and the like. The amount of the sweetener is preferably 0.01 to 1% of the whole composition.
Examples of preservatives include paraoxybenzoate, sodium benzoate and the like.
Examples of the pH adjuster include organic acids such as citric acid and lactic acid and salts thereof, and inorganic compounds such as hydrochloric acid, sodium hydroxide, potassium hydroxide, disodium hydrogen phosphate, and sodium dihydrogen phosphate.

  Examples of the flavor include known flavors such as menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineol, linalool, ethyl linalool, vanillin, thymol, spearmint oil, peppermint oil. , Lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, laurel oil, perilla oil, winter green oil, clove oil, eucalyptus oil and the like. The blending amount of the fragrance in the composition can be 0.01 to 1.5%.

  Pharmaceutical ingredients include enzymes such as dextranase, amylase, protease, and mutanase; anti-inflammatory agents such as tranexamic acid, epsilon aminocaproic acid, aluminum chlorohydroxyallantoin, azulene, glycyrrhizinate, glycyrrhetinate, sodium chloride, and vitamins Bactericides such as isopropylmethylphenol, copper chlorophyll, copper gluconate, cetylpyridinium chloride, benzalkonium chloride, hinokitiol, and lysozyme chloride; Amino acids can be blended. The compounding amount of the medicinal component can be an effective amount as long as the effect of the present invention is not impaired.

  In addition, as optional components, synthetic high molecular compounds such as polyvinyl acetate, acrylic, polyurethane, polyester, polyvinyl chloride, nylon powder, polyethylene powder and copolymers thereof, carnauba wax, rosin, rice wax, microcrystalline Waxes, beeswax, waxes such as paraffin wax, higher alcohols such as cetanol and stearyl alcohol, polyisobutylene, polybutadiene, urethane, silicone, and those obtained by crosslinking, polymerizing and molding latex rubber such as natural rubber, or And a film obtained by mixing these raw materials or a lame film can be used.

  The composition of the present invention can be prepared by a conventional method, similarly to the preparation for oral cavity. For example, a method in which a water-soluble component such as the component (B) is dissolved in the component (C), the component (A) is added, and if necessary, a thickener is added while heating to cause swelling is suitable.

The tooth whitening composition of the present invention is used in contact with the surface of a tooth. In this case, it is preferable to use an application tool for holding and fixing the tooth. The application tool assists the reliable application and fixation of the tooth whitening composition to the teeth, suppresses the dissolution of the composition during use to the gingiva, tongue and oral mucosa, and induces an unpleasant feeling of use and saliva. It is used for the purpose of preventing saliva intrusion, occlusion, chewing, and other physical stimuli, which may cause dilution of the composition or detachment from teeth.
Specific application forms include an adhesive sheet (pack) in which a paste-like composition is spread on a support, an impregnated sheet or body containing a liquid composition impregnated in a liquid-absorbent sheet or sponge, and a dental sheet. A tray, a mouth tray, a mouthpiece, a tooth cover molded into a tooth row, and the like are preferably used.
Examples of the support for the adhesive sheet include a fiber sheet such as a nonwoven fabric, a woven fabric, a knit, and a gauze, and a film. In particular, when the material on the surface (outside) where the composition is not spread is composed of a material having high hydrophilicity and high water absorption, for example, a fiber sheet using rayon, pulp, cotton, silk, paper, or the like, the material can be used in the mouth. It is preferable because it absorbs and retains saliva generated in the above. Furthermore, by combining a water-impermeable film such as polyethylene, polypropylene, or polyester on the surface on which the whitening composition is spread (applied to the teeth), it is possible to further prevent saliva from entering the whitening composition. It is possible and more preferred. The adhesive sheet in which the whitening composition of the present invention is spread on the support can be used by attaching the surface of the composition to teeth.
Examples of the sheet of the impregnated sheet include a sheet having a liquid absorbing property such as a nonwoven fabric, a woven fabric, a net cloth, and a gauze. The sheet can be used by impregnating the liquid composition with the liquid composition and applying the liquid composition to teeth.
Dental trays, mouth trays, mouthpieces, tooth-shaped tooth covers can be applied to put the paste-like composition into the mouthpiece and contact the teeth.

The time for bringing the whitening composition of the present invention into contact with the teeth is preferably 3 to 15 minutes. When applied in this manner, the whitening effect and the stain removing effect are more excellent. If the time of contact with the tooth is less than 3 minutes, a sufficient stain removing effect and whitening effect may not be obtained, and if it exceeds 15 minutes, irritation may occur.
After use, the composition may be wiped off the surface of the teeth with paper or cloth, or the teeth may be brushed with a toothbrush or the like. In addition, it is possible to rinse the mouth with water as appropriate, but after using it, after using it, wipe the composition with paper or cloth, and then rinse the mouth once with a small amount of water. preferable.

  Although the tooth whitening composition of the present invention can be applied to a tooth as it is, the tooth whitening composition can be securely held on the tooth, and can be applied using a tooth whitening set used in combination with an application tool that can be fixed. it can. After application to the teeth for a predetermined time, the composition may be removed by wiping, but more preferably by brushing with a toothbrush or the like while the composition remains attached to the teeth, a physical removal force is also added, and the teeth are removed. The ability to remove stains such as coloring matter adhered to the surface is enhanced, and the whitening effect is improved.

  Incidentally, the tooth whitening set of the present invention is a method in which the tooth whitening composition is previously fixed to the tool by means of pasting, dipping, adhering, crimping, spraying, applying, burying, etc. A tooth whitening composition and a tool are separately prepared, and either a method in which the composition is fixed to the tool at the time of use and then worn on the teeth, or a method in which the tooth whitening composition is adhered to the teeth and then coated with the tool. Can also achieve the purpose.

  Hereinafter, the present invention will be described specifically with reference to Examples, Comparative Examples, and Formulation Examples, but the present invention is not limited to the following Examples. In the following examples,% indicates mass% unless otherwise specified.

[Examples and Comparative Examples]
Tooth whitening compositions having the compositions shown in Tables 1 and 2 were prepared and evaluated by the following methods. The results are shown in the table.

<Method for Preparing Tooth Whitening Composition Sample>
While stirring the purified water with a disper stirrer (manufactured by Ishiyama Shoten), sodium tripolyphosphate or sodium pyrophosphate was added and dissolved, and then 1,3-butylene glycol or polyethylene glycol 400 was added and mixed. Subsequently, after adding and dispersing hydroxypropyl cellulose, stirring was continued while heating until hydroxypropyl cellulose swelled. It was left at room temperature to obtain a gel-like tooth whitening composition. In addition, the composition of the comparative example was prepared according to the above method.

<Evaluation of whitening effect>
A human extracted tooth whose color difference (L * value) on the tooth surface was measured using a spectral color difference meter (manufactured by Nippon Denshoku Industries Co., Ltd., model: SE-2000) was immersed in the tooth whitening composition in advance. (37 ° C., 10 minutes), the tooth whitening composition adhered to the tooth surface with paper was wiped off, and the color difference (L * value) of the tooth surface was measured. The whitening effect was evaluated based on the difference (ΔL *) of the L * value before and after the immersion treatment according to the following criteria, and the whitening effect of the teeth was determined.
Judgment criteria ：: ΔL *> 4
：: 4 ≧ ΔL *> 2
×: 2 ≧ ΔL *

<Evaluation of stain removal effect>
1. Method for producing stain-attached HAP The surface of hydroxyapatite pellets (HAP, manufactured by HOYA Corporation, diameter 7 mm × thickness 3.5 mm) was treated by sandblasting, and then washed in an aqueous neutral detergent solution with an ultrasonic cleaner. Next, the operation of repeatedly immersing the HAP in a 0.5% aqueous albumin solution → tannin extract solution → 0.6% aqueous ammonium iron (III) citrate solution for 1 hour was repeated 50 times, and air-dried at room temperature for 1 day. After washing with running water and drying again with air, a stain-adhered HAP was produced.
The tannin extract was prepared by mixing 50 g of Japanese tea (brand name: Akashi), 5 bags of black tea (manufactured by Unilever Japan, Brisk tea bag) in 1,200 mL of boiled ion-exchanged water, and instant coffee (trade name). : Nescafe, manufactured by Nestlé Japan Co., Ltd.), and allowed to stand overnight to remove Japanese tea and black tea by filtration. The color difference (L * value) of the surface of the produced stain-attached HAP was measured using a spectroscopic color difference meter (manufactured by Nippon Denshoku Industries Co., Ltd., model: SE-2000), and the L * value before treatment was measured. And
2. Stain removal test The stain-attached HAP produced by the above method was immersed in the tooth whitening composition of the test sample for 10 minutes, and then the tooth whitening composition attached to the HAP surface was wiped off with paper and washed in running water. , The L * value of the HAP surface was measured, and this was taken as the L * value after the treatment. The stain removal effect was evaluated based on the following criterion for the difference (ΔL *) between L * values before and after treatment, and the stain removal effect of the tooth was determined.
Judgment criteria A: ΔL *> 10
：: 10 ≧ ΔL *> 3
×: 3 ≧ ΔL *

<Evaluation of feeling of use (no irritation)>
The feeling of use was evaluated by five subjects. An appropriate amount of the tooth whitening composition was placed in an upper jaw mouse tray (manufactured by Butler), and the absence of irritation when worn on the upper jaw for 10 minutes was evaluated according to the following criteria.
Criteria ◎: I did not feel irritation ○: I did not feel much irritation △: I felt some irritation ×: I felt irritation

  As shown in Table 2, Comparative Example 1 containing the component (A) and not containing the component (B) is inferior in the stain removing effect, and contains the component (B) and does not contain the component (A). In Comparative Examples 2 and 3, even if polyethylene glycol 200 or propylene glycol was contained, the whitening effect was inferior (Comparative Examples 2 and 3). In Examples 4 to 6, in Comparative Example 4 in which the water content was too large, the whitening effect was poor, and even when the water content was appropriate, the mass ratio of (B) / water was too large in Comparative Example 5 or In Comparative Example 6, which did not contain water, the stain removing effect was inferior, irritation was felt, and the feeling in use was inferior. On the other hand, as shown in Examples of Tables 1 and 2, the component (A), the component (B) and the component (C) are contained, the component (A) is a specific amount or more, and the component (C) is The composition of the present invention (Examples 1 to 14) in which the mass ratio of (B) / (C) is equal to or less than a specific value and the mass ratio of (B) / (C) is equal to or less than the specific value has a stain removing effect of removing stain accumulated on the tooth surface and a short-time treatment However, the whitening effect for whitening the teeth was excellent, and the feeling of use (no irritation) was also good.

The details of the raw materials used are shown below.
(A) 1,3-butylene glycol: manufactured by Daicel Corporation, 1,3-butylene glycol (A) polyethylene glycol 400:
PEG # 400 manufactured by Lion Specialty Chemicals Co., Ltd.
(B) Sodium tripolyphosphate: manufactured by Taihei Chemical Industry Co., Ltd., sodium tripolyphosphate (B) sodium pyrophosphate: manufactured by Taihei Chemical Industry Co., Ltd., anhydrous sodium pyrophosphate polyethylene glycol 200:
PEG # 200 manufactured by Lion Specialty Chemicals Co., Ltd.
Propylene glycol:
Propylene glycol hydroxypropyl cellulose manufactured by ADEKA Corporation:
Hydroxypropylcellulose M, manufactured by Nippon Soda Co., Ltd.

  Next, a prescription example is shown. The following tooth whitening composition was prepared in the same manner using the same raw materials, and was applied to the teeth by attaching it to the upper jaw for 10 minutes in the same manner as in the method for evaluating the feeling of use. Thereafter, the tooth surface was wiped with a commercially available tissue paper. As a result, it was confirmed that the whitening effect and the stain removing effect were high, the teeth were whitened after use, and the teeth were not irritated.

[Formulation Example 1] (impregnated sheet agent)
<Preparation method>
Sodium tripolyphosphate was added and dissolved in purified water while stirring with a disper stirrer, and 1,3-butylene glycol was added. Subsequently, after adding and dissolving sodium lauryl sulfate, a fragrance was added and mixed. The obtained liquid tooth whitening composition was impregnated with a commercially available gauze to prepare an impregnated sheet agent.
(A) 1,3-butylene glycol 85.0%
(B) Sodium tripolyphosphate 1.0
Sodium lauryl sulfate 0.3
Fragrance ^* 1.0
(C) Purified water 12.7
100.0% in total
* Fragrance: a fragrance composition having the composition shown in Tables 3 and 4 (hereinafter the same).

[Formulation Example 2] Adhesive sheet (pack)
<Preparation method>
Sodium tripolyphosphate was added and dissolved in purified water while stirring with a disper stirrer, and 1,3-butylene glycol was added. Subsequently, hydroxyethyl cellulose was added and swelled at 70 ° C. with stirring. The swollen gel-like tooth whitening composition was placed in a kneader (manufactured by Ishiyama Shoten), and a fragrance and sodium lauryl sulfate were added and mixed under reduced pressure.
The obtained composition was spread on a three-layer nonwoven fabric of rayon / polyethylene / polyethylene terephthalate to prepare an adhesive sheet.
(A) 1,3-butylene glycol 85.0%
(B) Sodium tripolyphosphate 0.2
Sodium lauryl sulfate 0.2
Hydroxyethyl cellulose 6.0
Fragrance ^* 1.0
(C) Purified water 7.6
100.0% in total

Claims (6)

(A) 70% by mass or more of one or more polyhydric alcohols selected from 1,3-butylene glycol and polyethylene glycol having an average molecular weight of 380 to 630,
A composition for tooth whitening, comprising (B) a condensed phosphate and (C) water of 15% by mass or less, and (B) / (C) having a mass ratio of 0.18 or less.   The tooth whitening composition according to claim 1, wherein the component (A) is blended as a tooth whitening component, and the content of the polyhydric alcohol is 70 to 95% by mass.   The tooth whitening composition according to claim 1 or 2, wherein the content of (C) water is 1 to 15% by mass, and (B) / (C) is 0.01 to 0.18 by mass ratio.   The composition for whitening teeth according to any one of claims 1 to 3, wherein the content of the condensed phosphate (B) is 0.1 to 3% by mass.   The tooth whitening composition according to any one of claims 1 to 4, further comprising a thickener in an amount of 0.2 to 5% by mass.   A tooth whitening composition according to any one of claims 1 to 5, and an application tool that is applied while being held in contact with a tooth while being held in a detachable manner. Characteristic whitening set for teeth.