CN114617791B - Dental sand blasting powder composition and application thereof - Google Patents
Dental sand blasting powder composition and application thereof Download PDFInfo
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- CN114617791B CN114617791B CN202210225105.1A CN202210225105A CN114617791B CN 114617791 B CN114617791 B CN 114617791B CN 202210225105 A CN202210225105 A CN 202210225105A CN 114617791 B CN114617791 B CN 114617791B
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- blasting powder
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- 239000000843 powder Substances 0.000 title claims abstract description 93
- 239000000203 mixture Substances 0.000 title claims abstract description 62
- 238000005488 sandblasting Methods 0.000 title claims abstract description 49
- 238000004140 cleaning Methods 0.000 claims abstract description 24
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 17
- 239000000654 additive Substances 0.000 claims abstract description 11
- 230000000996 additive effect Effects 0.000 claims abstract description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 39
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 38
- 238000005422 blasting Methods 0.000 claims description 25
- 239000004471 Glycine Substances 0.000 claims description 19
- 239000004386 Erythritol Substances 0.000 claims description 18
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 18
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 18
- 229940009714 erythritol Drugs 0.000 claims description 18
- 235000019414 erythritol Nutrition 0.000 claims description 18
- 239000001685 glycyrrhizic acid Substances 0.000 claims description 15
- 239000000377 silicon dioxide Substances 0.000 claims description 15
- ILRKKHJEINIICQ-OOFFSTKBSA-N Monoammonium glycyrrhizinate Chemical compound N.O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O ILRKKHJEINIICQ-OOFFSTKBSA-N 0.000 claims description 11
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 9
- 238000005270 abrasive blasting Methods 0.000 claims description 8
- 239000003899 bactericide agent Substances 0.000 claims description 4
- 239000007844 bleaching agent Substances 0.000 claims description 4
- 239000005454 flavour additive Substances 0.000 claims description 4
- 235000013355 food flavoring agent Nutrition 0.000 claims description 4
- 230000000202 analgesic effect Effects 0.000 claims description 3
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract description 20
- 235000019640 taste Nutrition 0.000 abstract description 13
- 229940074774 glycyrrhizinate Drugs 0.000 abstract description 10
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 9
- 239000002245 particle Substances 0.000 description 23
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical group [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 22
- 235000012239 silicon dioxide Nutrition 0.000 description 12
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 11
- 235000017557 sodium bicarbonate Nutrition 0.000 description 11
- 239000000463 material Substances 0.000 description 10
- 239000004576 sand Substances 0.000 description 9
- 230000000052 comparative effect Effects 0.000 description 8
- 238000011156 evaluation Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 5
- 241000605862 Porphyromonas gingivalis Species 0.000 description 5
- 229960003260 chlorhexidine Drugs 0.000 description 5
- 230000002401 inhibitory effect Effects 0.000 description 5
- 235000019643 salty taste Nutrition 0.000 description 5
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 4
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 4
- 229960004949 glycyrrhizic acid Drugs 0.000 description 4
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 4
- 235000019410 glycyrrhizin Nutrition 0.000 description 4
- 208000028169 periodontal disease Diseases 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical class C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 4
- 230000001953 sensory effect Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- ZXHXYXSTAYNRLQ-DWJAGBRCSA-K tripotassium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4s,5s,6s)-2-[[(3s,4ar,6ar,6bs,8as,11s,12ar,14ar,14bs)-11-carboxylato-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1h-picen-3-yl]oxy]-6-carboxylato-4,5-dihydroxyoxan-3-yl]oxy-3,4, Chemical compound [K+].[K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C([O-])=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O ZXHXYXSTAYNRLQ-DWJAGBRCSA-K 0.000 description 4
- KPQJOKRSYYJJEL-VLQRKCJKSA-K [Na+].[Na+].CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C([O-])=O)O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C([O-])=O)C([O-])=O Chemical compound [Na+].[Na+].CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C([O-])=O)O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C([O-])=O)C([O-])=O KPQJOKRSYYJJEL-VLQRKCJKSA-K 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 3
- 235000019658 bitter taste Nutrition 0.000 description 3
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 description 3
- 210000000214 mouth Anatomy 0.000 description 3
- 239000000049 pigment Substances 0.000 description 3
- YLSUMFQEBHBMQB-OOFFSTKBSA-M potassium;(2s,3s,4s,5r,6s)-6-[[(3s,4ar,6ar,6bs,8as,11s,12ar,14ar,14bs)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1h-picen-3-yl]oxy]-5-[(2r,3r,4s,5s,6s)-6-carboxy-3,4,5-trihydroxyoxan-2-yl]oxy-3,4-dihydrox Chemical compound [K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O YLSUMFQEBHBMQB-OOFFSTKBSA-M 0.000 description 3
- 239000000779 smoke Substances 0.000 description 3
- 229940074777 tripotassium glycyrrhizinate Drugs 0.000 description 3
- 206010013911 Dysgeusia Diseases 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 210000004195 gingiva Anatomy 0.000 description 2
- 238000011086 high cleaning Methods 0.000 description 2
- 229940081974 saccharin Drugs 0.000 description 2
- 235000019204 saccharin Nutrition 0.000 description 2
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 1
- 208000007848 Alcoholism Diseases 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 241000287509 Piciformes Species 0.000 description 1
- 241001122767 Theaceae Species 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical group OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 238000002814 agar dilution Methods 0.000 description 1
- 201000007930 alcohol dependence Diseases 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- -1 analgesic Substances 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 229940078916 carbamide peroxide Drugs 0.000 description 1
- 230000001013 cariogenic effect Effects 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 229940106039 disodium glycyrrhizate Drugs 0.000 description 1
- 229910000514 dolomite Inorganic materials 0.000 description 1
- 239000010459 dolomite Substances 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 229960004393 lidocaine hydrochloride Drugs 0.000 description 1
- YECIFGHRMFEPJK-UHFFFAOYSA-N lidocaine hydrochloride monohydrate Chemical compound O.[Cl-].CC[NH+](CC)CC(=O)NC1=C(C)C=CC=C1C YECIFGHRMFEPJK-UHFFFAOYSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000005190 lower gingiva Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 229940085605 saccharin sodium Drugs 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 210000005189 upper gingiva Anatomy 0.000 description 1
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical group OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
- A61K8/022—Powders; Compacted Powders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
The invention provides a dental sand blasting powder composition, which comprises glycyrrhizinate and an additive. The dental sand blasting powder composition provided by the invention has the advantages of both cleaning efficiency and taste, and has high-efficiency antibacterial and anti-inflammatory effects.
Description
Technical Field
The invention belongs to the technical field of dental consumables, and particularly relates to a dental sand blasting powder composition and application thereof.
Background
The sand blasting technology uses compressed gas (usually air) to lift sand blasting powder to be sprayed on the tooth surface and is combined with liquid medium (usually water) sprayed together to clean the tooth surface. Can remove bacterial plaque, soft dirt, smoke stain, tea stain and the like on the surface of teeth, can effectively prevent periodontal disease and maintain tooth health.
The sand blasting powder is the most important consumable of the sand blasting teeth cleaning, so that a plurality of sand blasting powders are developed in a targeted way by the international main sand blasting powder manufacturers, and the types of the sand blasting powder (divided into basic components) are known to be sodium bicarbonate, glycine, erythritol and the like. For example, patent DE 20009665U1 provides a blasting powder whose main component is sodium bicarbonate or alumina or dolomite. A sodium bicarbonate sand powder which can be used in sandblasting apparatus is also provided in DE 10026718 A1. In US9358185B2 an amino acid containing blasting powder, in particular glycine, is provided. In addition, in EP2228175A1, there is provided a sugar alcohol-based grits, in particular erythritol. Factors influencing the use effect of the sand blasting powder mainly comprise the hardness of powder materials and the particle size of the powder. The hardness of the powder material determines whether the material can be used for cleaning teeth, and the material has poor cleaning effect and damages the tooth surface too hard. According to the clinical application scene of the sand blasting powder, the sand blasting powder for cleaning the upper gingiva and the sand blasting powder for cleaning the lower gingiva are divided. The sand blasting powder for cleaning and treating gingival is mainly used for removing bacterial plaque, pigment tartar and the like on the gingival. Subgingival cleaning and blasting powder mainly removes subgingival plaque, and particularly controls subgingival plaque for periodontitis patients.
For supragingival sand blasting powder, the most classical tooth cleaning sand blasting powder is sodium bicarbonate (the most common average particle size is 65 mu m), the cleaning efficiency is high, but the taste is very salty, and the patient comfort is poor and is not acceptable; commercial products improve mouthfeel by adding sugar or saccharin/saccharin salts to cover the salty taste of sodium bicarbonate. Sugar is not suitable for diabetics and is cariogenic; saccharin/saccharin salts do not cover the salty taste of sodium bicarbonate at normal doses, and too large a dose can result in bitter taste. Therefore, glycine sandblasted powder (the most common average particle size is 65 μm) for use on gingiva has been developed, which has low hardness, slightly sweet taste and high comfort level for patients, but has low cleaning efficiency, and cannot effectively remove smoke spots and pigments. And the patients who select sand blasting teeth cleaning are usually patients with serious smoke spots and pigments. Therefore, glycine sand blasting powder cannot well meet clinical requirements.
For subgingival sand blasting powder, glycine sand blasting powder (most common average particle size is 25 μm) used under gingiva first appears, but the requirement of patients with periodontal disease cannot be met well because the glycine sand blasting powder does not have continuous antibacterial effect, so that erythritol sand blasting powder containing 0.3% chlorhexidine (most common average particle size is 14 μm) is developed, and the added chlorhexidine has good antibacterial effect, but causes bitter taste, and causes discomfort to patients.
Therefore, the dental sand blasting powder with high cleaning efficiency, high comfort, high-efficiency antibacterial and anti-inflammatory effects and good taste is needed.
Disclosure of Invention
In view of the above, the technical problem to be solved by the present invention is to provide a dental sandblasting powder composition and application thereof, wherein the dental sandblasting powder composition provided by the present invention has both the cleaning efficiency and the taste, and has the efficient antibacterial and anti-inflammatory effects.
The invention provides a dental sand blasting powder composition, which comprises glycyrrhizinate.
Preferably, the glycyrrhetate is selected from one or more of glycyrrhizic acid, monopotassium glycyrrhizinate, dipotassium glycyrrhizinate, tripotassium glycyrrhizinate, disodium glycyrrhizinate and ammonium glycyrrhizinate.
Preferably, the glycyrrhetate is selected from ammonium glycyrrhetate.
Preferably, the average particle size of the glycyrrhetate is 5 to 100. Mu.m, preferably 5 to 65. Mu.m.
Preferably, the composition further comprises an additive selected from at least one of silica (micropowder), a bleaching agent, an analgesic agent, a bactericide and a flavoring additive.
Preferably, the method comprises the steps of: more than 85 weight percent of glycyrrhetate and the balance of additives.
Preferably, sodium bicarbonate, glycine or erythritol are also included.
Preferably, the method comprises the steps of:
85wt% or more of sodium bicarbonate, glycine or erythritol;
0.1 to 10 weight percent of glycyrrhetate;
the balance of additives.
The invention also provides application of the dental sand blasting powder composition in oral cavity cleaning.
Preferably, the abrasive blasting powder composition is used in an amount of 1 to 5g per tooth.
Compared with the prior art, the invention provides a dental sand blasting powder composition which comprises glycyrrhizinate and an additive. The dental sand blasting powder composition provided by the invention has the advantages of both cleaning efficiency and taste, and has high-efficiency antibacterial and anti-inflammatory effects.
Detailed Description
The invention provides a dental sand blasting powder composition, which comprises glycyrrhizinate.
Wherein the glycyrrhetate is selected from one or more of glycyrrhizic acid, monopotassium glycyrrhizinate, dipotassium glycyrrhizinate, tripotassium glycyrrhizinate, disodium glycyrrhizinate and ammonium glycyrrhizinate. In some preferred embodiments of the invention, the glycyrrhetate is selected from ammonium glycyrrhetate.
In the present invention, the average particle size of the glycyrrhetate is 5 to 100 μm, preferably 5 to 65 μm, or any value between 5, 10, 20, 30, 40, 50, 60, 65, 70, 80, 90, 100, or 5 to 100 μm.
In the invention, the glycyrrhetate is used as a basic component to prepare dental sand blasting powder or used as an auxiliary material of the dental sand blasting powder.
When the glycyrrhizinate is used as a base component to prepare the dental blasting powder, the dental blasting powder composition further comprises additives selected from the group consisting of silica (micropowder), bleaching agent, analgesic, bactericide and flavoring additive.
Wherein the bleaching agent is selected from carbamide peroxide, the bactericide is selected from triclosan, the analgesic is selected from lidocaine hydrochloride, and the flavoring additive is selected from edible essence.
Specifically, the dental abrasive blasting powder composition comprises: more than 85 weight percent of glycyrrhetate and the balance of additives.
In the present invention, the glycyrrhetate comprises from 85wt% to 99.5wt%, preferably from 85wt%, 90wt%, 95wt%, 97.5wt%,99.5wt%, or any value between 85wt% and 99.5wt% of the mass of the dental blasting composition.
The glycyrrhetate is used as a basic component to prepare the dental sand blasting powder, and meanwhile, the dental sand blasting powder has the multiple advantages of high cleaning efficiency, high comfort level and good antibacterial effect.
When the glycyrrhetate is used as an auxiliary material of the dental blasting powder, the dental blasting powder composition comprises sodium bicarbonate, glycine or erythritol.
Specifically, the dental abrasive blasting powder composition comprises:
85wt% or more of sodium bicarbonate, glycine or erythritol;
0.1 to 10 weight percent of glycyrrhetate;
the balance of additives.
Specifically, the dental blasting composition comprises 85wt% or more of sodium bicarbonate, glycine or erythritol, preferably 85wt% to 99.5wt%, or, preferably, 85wt%, 90wt%, 95wt%, 97.5wt%,99.5wt%, or any value between 60wt% and 99.5 wt%. The source of the sodium bicarbonate, glycine or erythritol is not particularly limited in the present invention, and sodium bicarbonate, glycine or erythritol which are known to those skilled in the art to be a basic component of dental blasting powder may be used.
The dental blasting composition further comprises 0.1wt% to 10wt% of a glycyrrhizinate, preferably 0.1wt%, 0.5wt%, 1wt%, 2wt%, 3wt%, 4wt%, 5wt%, 6wt%, 7wt%, 8wt%, 9wt%, 10wt%, or any value between 0.1wt% and 10 wt%.
The dental abrasive blasting powder composition also includes a contemplated additive.
The additives are as described above and are not described in detail herein.
The addition of glycyrrhizinate as an auxiliary material to sodium bicarbonate-based blasting powder unexpectedly improves the taste of sodium bicarbonate blasting powder compared to saccharin added in commercial products. Almost completely covers salty taste, and has no bad aftertaste.
When the glycyrrhizinate is used as an auxiliary material to be added into the erythritol-based sand blasting powder, compared with chlorhexidine added into a commercial product, the glycyrrhizinate has excellent taste and unexpectedly better antibacterial and anti-inflammatory effects.
In the present invention, the dental abrasive blasting powder composition can be used as a supragingival powder as well as a subgingival powder.
The method for preparing the dental blasting powder composition is not particularly limited, and may be any method known to those skilled in the art. In the invention, the raw materials are uniformly mixed.
The invention also provides the use of a dental abrasive blasting powder composition as described above in oral cleaning.
Specifically, the sand blasting powder composition is added into sand blasting tooth cleaning equipment, and the sand blasting tooth cleaning equipment is connected with a gas circuit and a water circuit;
and flushing the tooth surface by using the air path pressure of the air path of 3-6 Bar and the water path pressure of the water path of 3-4 Bar.
In the present invention, the abrasive blasting powder composition is used in an amount of 1 to 5g, preferably 1, 2, 3, 4, 5, or any value between 1 and 5g per tooth.
The dental sand blasting powder composition provided by the invention has the advantages of both cleaning efficiency and taste, and has high-efficiency antibacterial and anti-inflammatory effects.
For further understanding of the present invention, the dental blasting powder composition and application provided by the present invention are described below with reference to examples, and the scope of the present invention is not limited by the following examples.
Specific formulations of the dental blasting powder compositions are shown in tables 1 to 14 in examples 1 to 10 and comparative examples 1 to 4.
Example 1:
TABLE 1
| Composition of the composition | Content (mass percent) |
| Ammonium glycyrrhizate (particle size 65 mu m) | 97.5％ |
| Silicon dioxide (micropowder) | 2.5％ |
Example 2
TABLE 2
| Composition of the composition | Content (mass percent) |
| Ammonium glycyrrhizate (particle size 14 μm) | 97.5％ |
| Silicon dioxide (micropowder) | 2.5％ |
Example 3
TABLE 3 Table 3
| Composition of the composition | Content (mass percent) |
| Sodium bicarbonate (particle size 65 μm) | 95.5％ |
| Silicon dioxide (micropowder) | 2.5％ |
| Ammonium glycyrrhizate (particle size 65 mu m) | 2％ |
Example 4
TABLE 4 Table 4
| Composition of the composition | Content (mass percent) |
| Glycine (particle size 25 μm) | 95.5％ |
| Silicon dioxide (micropowder) | 2.5％ |
| Ammonium glycyrrhizate (particle size 25 μm) | 2％ |
Example 5
TABLE 5
| Composition of the composition | Content (mass percent) |
| Erythritol (particle size 14 μm) | 95.5％ |
| Silicon dioxide (micropowder) | 2.5％ |
| Ammonium glycyrrhizate (particle size 14 μm) | 2％ |
Example 6
TABLE 6
| Composition of the composition | Content (mass percent) |
| Glycyrrhizic acid (particle size 65 μm) | 97.5％ |
| Silicon dioxide (micropowder) | 2.5％ |
Example 7
TABLE 7
Example 8
TABLE 8
| Composition of the composition | Content (mass percent) |
| Dipotassium glycyrrhizinate (particle size 65 μm) | 97.5％ |
| Silicon dioxide (micropowder) | 2.5％ |
Example 9
TABLE 9
| Composition of the composition | Content (mass percent) |
| Tripotassium glycyrrhizinate (particle size 65 μm) | 97.5％ |
| Silicon dioxide (micropowder) | 2.5％ |
Example 10
Table 10
| Composition of the composition | Content (mass percent) |
| Glycyrrhizic acidDisodium (particle size 65 μm) | 97.5％ |
| Silicon dioxide (micropowder) | 2.5％ |
Comparative example 1
TABLE 11
| Composition of the composition | Content (mass percent) |
| Glycine (particle size 65 μm) | 97.5％ |
| Silicon dioxide (micropowder) | 2.5％ |
Comparative example 2
Table 12
| Composition of the composition | Content (mass percent) |
| Sodium bicarbonate (particle size 65 μm) | 95.5％ |
| Silicon dioxide (micropowder) | 2.5％ |
| Saccharin sodium (particle size 65 μm) | 2％ |
Comparative example 3
TABLE 13
| Composition of the composition | Content (mass percent) |
| Glycine (particle size 25 μm) | 97.5％ |
| Silicon dioxide (micropowder) | 2.5％ |
Comparative example 4
TABLE 14
Experimental example 1: taste evaluation test
The evaluation group consists of 10 laboratory members, 5 men and women respectively, and the members of the group are healthy, have no bad hobbies such as smoking, alcoholism and the like, and have stronger resolution and higher sensitivity on color, fragrance and taste. All samples were randomly coded, 1g of the grit blasted powder was dissolved in 100ml of water, the mouthfeel was assessed at room temperature, and the mouth was rinsed with warm water to keep the mouth fresh before sensory evaluation. Scoring (0-3 points) was performed according to the sensory evaluation reference criteria of table 15, and finally the average score was calculated. The results are shown in Table 16. It can be seen from examples 1 and 2 that the blasting powder made of ammonium glycyrrhizate has a very good taste. As can be seen from example 3 and comparative example 2, the addition of ammonium glycyrrhizinate as an auxiliary material to sodium bicarbonate-based blasting powder unexpectedly improved the taste of sodium bicarbonate blasting powder compared to saccharin added in a commercially available product. Almost completely covers salty taste, and has no bad aftertaste. As can be seen from example 5 and comparative example 4, the addition of glycyrrhizinate as an auxiliary material to erythritol-based blasting powder greatly improved the mouthfeel compared to chlorhexidine added in commercially available products. Furthermore, it can be seen from examples 1 and examples 6 to 10 that the substitution of ammonium glycyrrhizate with glycyrrhizic acid, monopotassium glycyrrhizate, dipotassium glycyrrhizate, tripotassium glycyrrhizate, disodium glycyrrhizate is substantially free from differences in effect.
TABLE 15 sensory evaluation reference criteria
| Standard of | Scoring |
| Salty or bitter, unacceptable | 0 |
| Salty or bitter, and unacceptable | 1 |
| Slightly salty or bitter, can be accepted | 2 |
| Has no salty or bitter taste, and good taste | 3 |
TABLE 16 sensory evaluation results
Experimental example 2:
to determine the cleaning efficiency of the above comparative powder and the powder provided herein, a test was performed on a pop can coating by means of a commercially available grit blasting bonding apparatus (ultrasonic grit blaster periodontal treatment, gui Linshi woodpecker medical instruments limited): areas of the can coating 1cm x 1cm were each treated with powder grit blasting until the area was completely clean. The time required for the measurement is measured. Taking into account the statistical variation, each test was repeated ten times and averaged. The results are shown in Table 17.
TABLE 17 cleaning efficiency of different powders
Analysis of the results in Table 17: as can be seen from group 1 (supragingival powder), the cleaning efficiency of ammonium glycyrrhizinate-based sand powder is higher than that of glycine-based sand powder and erythritol-based sand powder; as can be seen from group 2 (subgingival powder), the cleaning efficiency of ammonium glycyrrhizinate-based sand powder was also higher than that of glycine-based sand powder and erythritol-based sand powder.
Experimental example 3: antibacterial property test against periodontal disease pathogenic bacteria
The present study tested the effect of different subgingival sandblastings on Porphyromonas gingivalis, the primary pathogenic bacteria of periodontal disease. With reference to the method for determining the minimum inhibitory concentration (agar dilution method) in the ministry of health "sterilization technical Specification (2002 edition), experiments of the Minimum Inhibitory Concentration (MIC) of Porphyromonas gingivalis were carried out with different subgingival sandblasting powders, and the experiments were carried out in parallel for 3 times. The results of the experiment of the minimum inhibitory concentration of different subgingival sand blasting powders on Porphyromonas gingivalis are shown in Table 18.
TABLE 18 results of minimum inhibitory concentration experiments of different subgingival sandblasted powders on Porphyromonas gingivalis
Analysis of the results in table 18 reveals that: the minimum inhibitory concentration of Porphyromonas gingivalis containing the ammonium glycyrrhetate sand blasting powder is lower, namely the antibacterial and anti-inflammatory effects are better. In particular, as is clear from group 1, ammonium glycyrrhizinate-based sand powder has a very low MIC compared to erythritol-based sand powder, and exhibits an extremely excellent antibacterial and anti-inflammatory effect. As can be seen from group 2, the substitution of chlorhexidine in erythritol-based sandblasting powder with ammonium glycyrrhizate greatly reduces the MIC thereof, and the antibacterial and anti-inflammatory effects thereof are greatly improved.
The foregoing is merely a preferred embodiment of the present invention and it should be noted that modifications and adaptations to those skilled in the art may be made without departing from the principles of the present invention, which are intended to be comprehended within the scope of the present invention.
Claims (5)
1. The dental sand blasting powder composition is characterized by comprising ammonium glycyrrhizate, wherein the average granularity of the ammonium glycyrrhizate is 5-65 mu m, and the content of the ammonium glycyrrhizate in the composition is 95% -99.5%.
2. The dental grit blasting powder composition of claim 1, further comprising an additive selected from at least one of a silica micropowder, a bleach, an analgesic, a bactericide and a flavoring additive.
3. The dental grit blasting powder composition of claim 1, further comprising sodium bicarbonate, glycine or erythritol.
4. Use of a dental abrasive blasting powder composition according to any one of claims 1 to 3 for the preparation of an oral cleaning composition.
5. The use according to claim 4, characterized in that the blasting powder composition is used in an amount of 1 to 5g per tooth.
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