CN114617791A - Dental sandblasting powder composition and application - Google Patents
Dental sandblasting powder composition and application Download PDFInfo
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- CN114617791A CN114617791A CN202210225105.1A CN202210225105A CN114617791A CN 114617791 A CN114617791 A CN 114617791A CN 202210225105 A CN202210225105 A CN 202210225105A CN 114617791 A CN114617791 A CN 114617791A
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- CN
- China
- Prior art keywords
- powder composition
- dental
- powder
- glycyrrhetate
- glycyrrhizinate
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- 239000000843 powder Substances 0.000 title claims abstract description 103
- 239000000203 mixture Substances 0.000 title claims abstract description 50
- 238000005488 sandblasting Methods 0.000 title abstract description 37
- 238000004140 cleaning Methods 0.000 claims abstract description 18
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 17
- 239000000654 additive Substances 0.000 claims abstract description 15
- 230000000996 additive effect Effects 0.000 claims abstract description 7
- 238000005422 blasting Methods 0.000 claims description 57
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 38
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 32
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 23
- 239000004386 Erythritol Substances 0.000 claims description 22
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 22
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 22
- 229940009714 erythritol Drugs 0.000 claims description 22
- 235000019414 erythritol Nutrition 0.000 claims description 22
- 239000002245 particle Substances 0.000 claims description 20
- 239000004471 Glycine Substances 0.000 claims description 19
- 239000000377 silicon dioxide Substances 0.000 claims description 15
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 10
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims description 5
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 claims description 5
- KPQJOKRSYYJJEL-VLQRKCJKSA-K [Na+].[Na+].CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C([O-])=O)O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C([O-])=O)C([O-])=O Chemical compound [Na+].[Na+].CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C([O-])=O)O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C([O-])=O)C([O-])=O KPQJOKRSYYJJEL-VLQRKCJKSA-K 0.000 claims description 5
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims description 5
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims description 5
- 229960004949 glycyrrhizic acid Drugs 0.000 claims description 5
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims description 5
- 239000001685 glycyrrhizic acid Substances 0.000 claims description 5
- 235000019410 glycyrrhizin Nutrition 0.000 claims description 5
- ZXHXYXSTAYNRLQ-DWJAGBRCSA-K tripotassium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4s,5s,6s)-2-[[(3s,4ar,6ar,6bs,8as,11s,12ar,14ar,14bs)-11-carboxylato-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1h-picen-3-yl]oxy]-6-carboxylato-4,5-dihydroxyoxan-3-yl]oxy-3,4, Chemical compound [K+].[K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C([O-])=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O ZXHXYXSTAYNRLQ-DWJAGBRCSA-K 0.000 claims description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 4
- 239000003899 bactericide agent Substances 0.000 claims description 4
- 239000007844 bleaching agent Substances 0.000 claims description 4
- YLSUMFQEBHBMQB-OOFFSTKBSA-M potassium;(2s,3s,4s,5r,6s)-6-[[(3s,4ar,6ar,6bs,8as,11s,12ar,14ar,14bs)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1h-picen-3-yl]oxy]-5-[(2r,3r,4s,5s,6s)-6-carboxy-3,4,5-trihydroxyoxan-2-yl]oxy-3,4-dihydrox Chemical compound [K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O YLSUMFQEBHBMQB-OOFFSTKBSA-M 0.000 claims description 4
- 229940074777 tripotassium glycyrrhizinate Drugs 0.000 claims description 4
- 230000000202 analgesic effect Effects 0.000 claims description 3
- 239000005454 flavour additive Substances 0.000 claims description 3
- 235000013355 food flavoring agent Nutrition 0.000 claims description 3
- -1 analgesic Substances 0.000 claims 1
- 235000019640 taste Nutrition 0.000 abstract description 12
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 9
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical group [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 22
- 235000012239 silicon dioxide Nutrition 0.000 description 13
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 11
- 235000017557 sodium bicarbonate Nutrition 0.000 description 11
- 239000000463 material Substances 0.000 description 10
- 230000000052 comparative effect Effects 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 238000011156 evaluation Methods 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 5
- 241000605862 Porphyromonas gingivalis Species 0.000 description 5
- 229960003260 chlorhexidine Drugs 0.000 description 5
- 230000002401 inhibitory effect Effects 0.000 description 5
- 235000019643 salty taste Nutrition 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical class C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 4
- 230000001953 sensory effect Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 206010013911 Dysgeusia Diseases 0.000 description 3
- 235000019658 bitter taste Nutrition 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 208000028169 periodontal disease Diseases 0.000 description 3
- 239000000049 pigment Substances 0.000 description 3
- 241000208125 Nicotiana Species 0.000 description 2
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000005034 decoration Methods 0.000 description 2
- 229940074774 glycyrrhizinate Drugs 0.000 description 2
- 238000011086 high cleaning Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000003239 periodontal effect Effects 0.000 description 2
- 229940081974 saccharin Drugs 0.000 description 2
- 235000019204 saccharin Nutrition 0.000 description 2
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 2
- 239000004576 sand Substances 0.000 description 2
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical class OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 1
- 208000007848 Alcoholism Diseases 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 208000002064 Dental Plaque Diseases 0.000 description 1
- 241000287509 Piciformes Species 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical group OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- 238000002814 agar dilution Methods 0.000 description 1
- 201000007930 alcohol dependence Diseases 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 229940078916 carbamide peroxide Drugs 0.000 description 1
- 230000001013 cariogenic effect Effects 0.000 description 1
- 239000000551 dentifrice Substances 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 229910000514 dolomite Inorganic materials 0.000 description 1
- 239000010459 dolomite Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000011194 food seasoning agent Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 210000004195 gingiva Anatomy 0.000 description 1
- 229960004393 lidocaine hydrochloride Drugs 0.000 description 1
- YECIFGHRMFEPJK-UHFFFAOYSA-N lidocaine hydrochloride monohydrate Chemical group O.[Cl-].CC[NH+](CC)CC(=O)NC1=C(C)C=CC=C1C YECIFGHRMFEPJK-UHFFFAOYSA-N 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical group OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
- A61K8/022—Powders; Compacted Powders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
The invention provides a dental sandblasting powder composition, which comprises glycyrrhetate and an additive. The dental sandblasting powder composition provided by the invention has the problems of cleaning efficiency and taste, and has high-efficiency antibacterial and anti-inflammatory effects.
Description
Technical Field
The invention belongs to the technical field of dental consumables, and particularly relates to a dental sandblasting powder composition and application thereof.
Background
The blasting technique is to spray a blasting powder onto the tooth surface by using a compressed gas (usually air) and to combine the blasting powder with a liquid medium (usually water) sprayed together to clean the tooth surface. Can specifically remove dental plaque, soft dirt, smoke stain, tea stain and the like on the surface of teeth, can effectively prevent periodontal disease and maintain the health of teeth.
The blasting powder is the most important consumable material for cleaning teeth by blasting, various blasting powders have been developed by the main blasting powder manufacturers internationally, and the types (divided according to basic components) of the blasting powders are known to be sodium bicarbonate, glycine, erythritol and the like. For example, patent DE 20009665U1 provides a blasting powder whose main component is sodium bicarbonate or alumina or dolomite. DE 10026718a1 also provides a sodium bicarbonate sand powder which can be used in sand blasting devices. In US9358185B2 there is provided a blasting powder comprising amino acids, in particular glycine. Furthermore, a sugar alcohol-based granulated powder, in particular erythritol, is provided in EP2228175a 1. Factors influencing the using effect of the sand blasting powder mainly comprise the hardness of the powder material and the particle size of the powder. The hardness of the powder material determines whether the material can be used for cleaning teeth, and the material is too soft and has poor cleaning effect, and the material is too hard to damage the tooth surface. According to the clinical application scene of the sand blasting powder, the method is divided into supragingival scaling sand blasting powder and subgingival scaling sand blasting powder. The supragingival scaling sand blasting powder is mainly used for removing bacterial plaque, pigment, tartar and the like on gingiva. Subgingival scaling blasting powders primarily remove subgingival plaque, particularly for the control of subgingival plaque in periodontitis patients.
For the supragingival sandblasting powder, the most classical dentifrice sandblasting powder is sodium bicarbonate (the most common average particle size is 65 μm), the cleaning efficiency is high, but the mouthfeel is very salty, the comfort of patients is poor, and the acceptability is difficult; commercial products improve the mouthfeel by adding sugar or saccharin/saccharin salts to cover the salty taste of sodium bicarbonate. But sugar is not suitable for diabetics and has cariogenic properties; saccharin/saccharin salts do not cover the salty taste of sodium bicarbonate at normal doses, and overdose can cause bitterness. Therefore, the glycine blasting powder (the most common mean particle size is 65 mu m) used on the gum is developed, has lower hardness, slightly sweet taste and higher using comfort level of patients, but has low cleaning efficiency and can not effectively remove tobacco spots and pigments. Patients who choose to sand blast to clean teeth are generally patients with serious tobacco spots and pigment. Therefore, the glycine blasting powder can not meet the clinical requirements well.
For the subgingival sandblasting powder, the most common glycine sandblasting powder (the most common average particle size is 25 μm) used subgingival is firstly developed, but the requirement of periodontal patients cannot be well met because the subgingival sandblasting powder does not have the continuous antibacterial effect, so that the erythritol sandblasting powder containing 0.3% of chlorhexidine (the most common average particle size is 14 μm) is developed, and the added chlorhexidine has the good antibacterial effect, but causes bitterness and discomfort to the patients.
Therefore, the dental sandblasting powder which has high cleaning efficiency, high comfort level, high-efficiency antibacterial and anti-inflammatory effects and good taste is urgently needed to be invented.
Disclosure of Invention
In view of the above, the technical problem to be solved by the present invention is to provide a dental blasting powder composition and an application thereof, wherein the dental blasting powder composition provided by the present invention simultaneously has the problems of cleaning efficiency and taste, and has high-efficiency antibacterial and anti-inflammatory effects.
The invention provides a dental sandblasting powder composition, which comprises glycyrrhetate.
Preferably, the glycyrrhetate is selected from one or more of glycyrrhizic acid, monopotassium glycyrrhizinate, dipotassium glycyrrhizinate, tripotassium glycyrrhizinate, disodium glycyrrhizinate and ammonium glycyrrhizinate.
Preferably, the glycyrrhetate is selected from ammonium glycyrrhetate.
Preferably, the average particle size of the glycyrrhetate is 5-100 μm, and preferably 5-65 μm.
Preferably, the liquid detergent further comprises an additive selected from at least one of silica (micropowder), a bleaching agent, an analgesic, a bactericide and a flavoring additive.
Preferably, the method comprises the following steps: more than 85 wt% of glycyrrhetate and the balance of additives.
Preferably, sodium bicarbonate, glycine or erythritol is also included.
Preferably, the method comprises the following steps:
more than 85 wt% of sodium bicarbonate, glycine or erythritol;
0.1-10 wt% glycyrrhetate;
the balance of additives.
The invention also provides application of the dental blasting powder composition in oral cleaning.
Preferably, the dosage of the sandblasting powder composition used for each tooth is 1-5 g.
Compared with the prior art, the invention provides a dental blasting powder composition which comprises glycyrrhetate and an additive. The dental sandblasting powder composition provided by the invention has the problems of cleaning efficiency and taste, and has high-efficiency antibacterial and anti-inflammatory effects.
Detailed Description
The invention provides a dental sandblasting powder composition, which comprises glycyrrhetate.
Wherein the glycyrrhetate is selected from one or more of glycyrrhizic acid, monopotassium glycyrrhizinate, dipotassium glycyrrhizinate, tripotassium glycyrrhizinate, disodium glycyrrhizinate, and ammonium glycyrrhizinate. In some preferred embodiments of the present invention, the glycyrrhetate is selected from ammonium glycyrrhetate.
In the invention, the average particle size of the glycyrrhetate is 5-100 μm, preferably 5-65 μm, or any value between 5, 10, 20, 30, 40, 50, 60, 65, 70, 80, 90, 100, or 5-100 μm.
In the invention, the glycyrrhetate is used as a basic component to prepare dental blasting powder or is used as an auxiliary material of the dental blasting powder.
When the glycyrrhetate is used as a basic component to prepare the dental blasting powder, the dental blasting powder composition also comprises an additive besides the glycyrrhetate, wherein the additive is selected from silicon dioxide (micropowder), a bleaching agent, an analgesic, a bactericide and a seasoning additive.
Wherein the bleaching agent is selected from carbamide peroxide, the bactericide is selected from triclosan, the analgesic agent is selected from lidocaine hydrochloride, and the flavoring additive is selected from flavoring essence.
Specifically, the dental blasting powder composition comprises: more than 85 wt% of glycyrrhetate and the balance of additives.
In the present invention, the glycyrrhetate accounts for 85 wt% to 99.5 wt%, preferably 85 wt%, 90 wt%, 95 wt%, 97.5 wt%, 99.5 wt%, or any value between 85 wt% to 99.5 wt% of the mass of the dental blasting composition.
The glycyrrhetate is used as a basic component to prepare the dental sandblasting powder, and has the multiple advantages of high cleaning efficiency, high comfort level and good antibacterial effect.
When the glycyrrhetate is used as an auxiliary material of the dental blasting powder, the dental blasting powder composition comprises sodium bicarbonate, glycine or erythritol.
Specifically, the dental blasting powder composition comprises:
more than 85 wt% of sodium bicarbonate, glycine or erythritol;
0.1-10 wt% glycyrrhetate;
the balance of additives.
Specifically, the dental blasting composition comprises more than 85 wt% of sodium bicarbonate, glycine or erythritol, preferably 85 wt% to 99.5 wt%, or preferably 85 wt%, 90 wt%, 95 wt%, 97.5 wt%, 99.5 wt%, or any value between 60 wt% and 99.5 wt%. The source of the sodium bicarbonate, glycine or erythritol is not particularly limited in the present invention, and sodium bicarbonate, glycine or erythritol which can be a basic component of dental blasting powder known to those skilled in the art may be used.
The dental blasting composition further comprises 0.1 wt% to 10 wt% glycyrrhetate, preferably 0.1 wt%, 0.5 wt%, 1 wt%, 2 wt%, 3 wt%, 4 wt%, 5 wt%, 6 wt%, 7 wt%, 8 wt%, 9 wt%, 10 wt%, or any value between 0.1 wt% to 10 wt%.
The dental blasting powder composition also includes the contemplated additives.
The additives are as described above and are not described in detail herein.
The glycyrrhizinate is added into the sodium bicarbonate-based sandblasting powder as an auxiliary material, and compared with saccharin added into a commercially available product, the taste of the sodium bicarbonate-based sandblasting powder is unexpectedly improved by using the glycyrrhizinate. Almost completely covers the salty taste and has no bad aftertaste.
The glycyrrhetate serving as an auxiliary material is added into the erythritol-based blasting powder, and compared with chlorhexidine added in a commercially available product, the erythritol-based blasting powder has excellent taste and unexpectedly has better antibacterial and anti-inflammatory effects.
In the present invention, the dental blasting powder composition may be used as a supragingival powder as well as a subgingival powder.
The method for preparing the dental blasting powder composition is not particularly limited, and the method known to those skilled in the art can be used. In the invention, the raw materials are mixed uniformly.
The invention also provides the application of the dental blasting powder composition in oral cleaning.
Specifically, the sand blasting powder composition is added into a sand blasting tooth cleaning device, and the sand blasting tooth cleaning device is connected with an air path and a water path;
the gas circuit pressure of the gas circuit is 3-6 Bar, and the water circuit pressure of the water circuit is 3-4 Bar, so that the tooth surface is washed.
In the present invention, the amount of the blasting powder composition used per tooth is 1 to 5g, preferably 1, 2, 3, 4, 5, or any value between 1 and 5 g.
The dental sandblasting powder composition provided by the invention has the problems of cleaning efficiency and taste, and has high-efficiency antibacterial and anti-inflammatory effects.
For further understanding of the present invention, the dental blasting powder composition and the application thereof provided by the present invention are described below with reference to the following examples, and the scope of the present invention is not limited by the following examples.
The specific formulation of the dental blasting powder composition is shown in tables 1 to 14 in examples 1 to 10 and comparative examples 1 to 4.
Example 1:
TABLE 1
| Composition of | Content (mass percent) |
| Ammonium glycyrrhizinate (particle size 65 μm) | 97.5％ |
| Silicon dioxide (micropowder) | 2.5％ |
Example 2
TABLE 2
| Make up of | Content (mass percentage) |
| Ammonium glycyrrhizinate (particle size 14 μm) | 97.5％ |
| Silicon dioxide (micropowder) | 2.5％ |
Example 3
TABLE 3
| Composition of | Content (mass percentage) |
| Sodium bicarbonate (particle size 65 μm) | 95.5％ |
| Silicon dioxide (micropowder) | 2.5％ |
| Ammonium glycyrrhizinate (particle size 65 μm) | 2％ |
Example 4
TABLE 4
| Make up of | Content (mass percentage) |
| Glycine (particle size 25 μm) | 95.5％ |
| Silicon dioxide (micropowder) | 2.5％ |
| Ammonium glycyrrhizinate (particle size 25 μm) | 2％ |
Example 5
TABLE 5
| Composition of | Content (mass)Percent) |
| Erythritol (particle size 14 μm) | 95.5％ |
| Silicon dioxide (micropowder) | 2.5％ |
| Ammonium glycyrrhizinate (particle size 14 μm) | 2％ |
Example 6
TABLE 6
| Composition of | Content (mass percentage) |
| Glycyrrhizic acid (grain size 65 μm) | 97.5％ |
| Silicon dioxide (micropowder) | 2.5％ |
Example 7
TABLE 7
Example 8
TABLE 8
| Composition of | Content (mass percentage) |
| Dipotassium glycyrrhizinate (grain size 65 μm) | 97.5％ |
| Silicon dioxide (micropowder) | 2.5％ |
Example 9
TABLE 9
| Composition of | Content (mass percentage) |
| Glycyrrhizic acid tripotassium salt (grain size 65 μm) | 97.5％ |
| Silicon dioxide (micropowder) | 2.5％ |
Example 10
Watch 10
| Composition of | Content (mass percentage) |
| Disodium glycyrrhizinate (particle size 65 μm) | 97.5％ |
| Silicon dioxide (micropowder) | 2.5％ |
Comparative example 1
TABLE 11
| Composition of | Content (mass percentage) |
| Glycine (particle size 65 μm) | 97.5％ |
| Silicon dioxide (micropowder) | 2.5％ |
Comparative example 2
TABLE 12
| Composition of | Content (mass percentage) |
| Sodium bicarbonate (particle size 65 μm) | 95.5％ |
| Silicon dioxide (micropowder) | 2.5％ |
| Saccharin sodium salt (grain diameter 65 μm) | 2％ |
Comparative example 3
Watch 13
| Composition of | Content (mass percentage) |
| Glycine (particle size 25 μm) | 97.5％ |
| Silicon dioxide (micropowder) | 2.5％ |
Comparative example 4
TABLE 14
Experimental example 1: taste evaluation test
The evaluation group consists of 10 laboratory members, 5 men and 5 women, and the members are healthy, have no bad taste such as smoking, alcoholism and the like, and have stronger resolving power and higher sensitivity on color, fragrance and taste. All samples were randomly number coded, 1g of grit blasting powder was dissolved in 100ml of water, evaluated for mouthfeel at room temperature, and rinsed with warm water to keep the mouth fresh before sensory evaluation. Scores (0-3 points) were made according to the sensory evaluation reference criteria of table 15, and finally an average score was calculated. The results are shown in Table 16. As can be seen from examples 1 and 2, the blasting powder made of ammonium glycyrrhetate had very good taste. As can be seen from example 3 and comparative example 2, the addition of ammonium glycyrrhizinate as an adjuvant to sodium bicarbonate-based blasting powder unexpectedly improved the taste of sodium bicarbonate blasting powder with ammonium glycyrrhizinate compared to saccharin added to commercially available products. Almost completely covers the salty taste and has no bad aftertaste. As can be seen from example 5 and comparative example 4, the addition of glycyrrhetate as an adjuvant to erythritol-based blasting powder greatly improved the mouthfeel as compared to chlorhexidine added to commercially available products. In addition, as can be seen from examples 1 and 6 to 10, the effect was substantially the same by replacing ammonium glycyrrhizinate with glycyrrhizic acid, monopotassium glycyrrhizinate, dipotassium glycyrrhizinate, tripotassium glycyrrhizinate, and disodium glycyrrhizinate.
TABLE 15 sensory evaluation reference standards
| Standard of merit | Scoring |
| Very salty or very bitter and unacceptable | 0 |
| Salty or bitter with unacceptable flavor | 1 |
| Slightly salty or slightly bitter, it is acceptable | 2 |
| Has no salty or bitter taste, and good taste | 3 |
TABLE 16 sensory evaluation results
Experimental example 2:
to determine the cleaning efficiency of the comparative powders described above and the powders provided herein, tests were performed on the can coatings by means of a commercially available grit blasting combination equipment (ultrasonic grit blasting periodontal therapy instrument, woodpecker medical instruments ltd, Guilin): a 1cm x 1cm area of the can coating was treated with powder blasting until the coating was completely clean in that area. The time required was measured. Each test was repeated ten times, taking the average, taking into account the statistical variations. The results are shown in Table 17.
TABLE 17 cleaning efficiency of different powders
Table 17 results were analyzed: as can be seen from group 1 (gingival powder), the cleaning efficiency of the ammonium glycyrrhizinate-based abrasive powder is higher than that of the glycine-based abrasive powder and the erythritol-based abrasive powder; as can be seen from group 2 (subgingival powder), the cleaning efficiency of the ammonium glycyrrhizinate-based abrasive powder is also higher than that of the glycine-based abrasive powder and the erythritol-based abrasive powder.
Experimental example 3: antibacterial property test for periodontal disease pathogenic bacteria
The study tested the effect of different subgingival sandblasting powders on the main pathogen of periodontal disease, porphyromonas gingivalis. With reference to the method for measuring the minimum inhibitory concentration (agar dilution method) in the disinfection technical specification (2002 edition) of the ministry of health, different subgingival sand blasting powders are adopted to carry out the experiment of the Minimum Inhibitory Concentration (MIC) of the porphyromonas gingivalis, and the experiment is carried out for 3 times in parallel. The results of the experiments on the minimum inhibitory concentration of different subgingival sandblasting powders on porphyromonas gingivalis are shown in table 18.
TABLE 18 results of experiments on the minimum inhibitory concentration of different subgingival sandblasting powders on Porphyromonas gingivalis
Analysis of the results in Table 18 shows that: the minimum inhibitory concentration of the porphyromonas gingivalis of the sandblasting powder containing the ammonium glycyrrhizinate is lower, namely the antibacterial and anti-inflammatory effects are better. In particular, as seen from group 1, the MIC of the ammonium glycyrrhizinate-based blasting powder was very low compared to the erythritol-based blasting powder, and an extremely excellent antibacterial and anti-inflammatory effect was exhibited. As shown in group 2, the chlorhexidine in the erythritol-based sandblasting powder is replaced by ammonium glycyrrhizinate, the MIC of the erythritol-based sandblasting powder is greatly reduced, and the antibacterial and anti-inflammatory effects of the erythritol-based sandblasting powder are greatly improved.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (10)
1. A dental blasting powder composition is characterized by comprising glycyrrhetate.
2. The dental blasting powder composition of claim 1, wherein the glycyrrhetate is selected from one or more of glycyrrhizic acid, monopotassium glycyrrhizinate, dipotassium glycyrrhizinate, tripotassium glycyrrhizinate, disodium glycyrrhizinate, and ammonium glycyrrhizinate.
3. The dental blasting powder composition of claim 1, wherein the glycyrrhetate is selected from ammonium glycyrrhetate.
4. A dental blasting powder composition according to claim 1, wherein the glycyrrhetate has an average particle size of 5 to 100 μm, preferably 5 to 65 μm.
5. The dental blasting powder composition of claim 1, further comprising an additive selected from at least one of silica (micropowder), bleach, analgesic, bactericide, and flavoring additive.
6. The dental blasting powder composition of claim 5, comprising: more than 85 wt% of glycyrrhetate and the balance of additives.
7. The dental blast powder composition according to claim 1, further comprising sodium bicarbonate, glycine, or erythritol.
8. The dental blasting powder composition of claim 7, comprising:
more than 85 wt% of sodium bicarbonate, glycine or erythritol;
0.1 wt% -10 wt% of glycyrrhetate;
the balance of additives.
9. Use of a dental blasting powder composition according to any of claims 1 to 8 for oral cleaning.
10. The use according to claim 9, wherein the blasting powder composition is used in an amount of 1 to 5g per tooth.
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