JP2006096696A - Composition for oral cavity - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a composition for the oral cavity, excellent in an effect of preventing and treating dentin hypersensitivity, excellent in an effect of cleaning stains on surfaces of teeth caused by tobacco tar, etc., and having a good sense of use when the teeth are brushed. <P>SOLUTION: This composition for the oral cavity contains (A) potassium nitrate in an amount of 0.1-10 mass%, (B) a straight-chain water-soluble polyphosphoric acid salt expressed by general formula: M<SB>n+2</SB>P<SB>n</SB>O<SB>3n+1</SB>(M is Na or K; and n is an integer of 2 or more) in an amount of 0.1-2.0 mass%, and (C) a polyhydric alcohol in an amount of 40-70 mass%, wherein a mass ratio of the potassium nitrate (A) to the straight-chain water-soluble polyphosphoric acid salt (B) is 1.5 to 50. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention is a combination of potassium nitrate and a linear water-soluble polyphosphate, which is excellent in preventing and treating dentin hypersensitivity, and also has a cleaning effect on tooth surface stains such as tobacco crabs and a feeling of use during dentifrice. Further, the present invention relates to an excellent oral composition.

  Dentine hypersensitivity is a transient effect caused by the loss of tooth enamel or cement and exposure of dentin, which is caused by external, thermal, chemical or mechanical stimuli. It is defined as a very unpleasant sexual pain. The cause of this pain is thought to be because the pulp nerve is stimulated through the exposed dentinal tubule.

  As measures for preventing dentin hypersensitivity, methods such as blocking dentinal tubules and blunting nerves are used. Patent Document 1 (Japanese Patent Laid-Open No. 61-36212), Patent Document 2 (Japanese Patent Laid-Open No. 7-165550) and the like are used to seal ivory tubules. It is known that potassium nitrate, which is known as an active ingredient for preventing hypersensitivity, is added to an oral composition (Patent Document 3: Japanese Patent Laid-Open No. 8-175934). For example, US Pat. No. 3,863,006 discloses that dentifrices containing potassium salts, such as potassium nitrate, reduce tooth sensitivity after several weeks of brushing.

  However, even if these methods are used, it takes a period of one month or more to reduce or eliminate pain, and the present condition is accompanied by pain of the onset. In particular, it is difficult to brush during toothpaste because it causes pain during toothpaste, and stains such as stains, plaques, foods, and tobacco stains that adhere to and deposit on the tooth surface are difficult. There was a problem in that it could not be removed sufficiently and adversely affected the maintenance of oral hygiene. Therefore, in use in the state having hypersensitivity symptoms, the composition for oral cavity is excellent in prevention and treatment effects of hypersensitivity symptoms, has a sufficient tooth surface cleaning effect, and has good usability. Development is desired.

JP-A-61-36212 Japanese Patent Laid-Open No. 7-165550 Japanese Patent Laid-Open No. 8-175934 U.S. Pat. No. 3,863,006 JP 9-175966 A JP 11-343220 A JP 2000-281549 A Japanese National Patent Publication No. 11-510161 JP 2004-10576 A JP 2004-26724 A

  The present invention has been made in view of the above circumstances, and has an excellent prevention and treatment effect on dentin hypersensitivity, an excellent cleaning effect on tooth surface stains such as tobacco spear, and a good use feeling during dentifrice The purpose is to provide goods.

  As a result of intensive studies to achieve the above object, the present inventor has obtained 0.1 to 10% by mass of potassium nitrate and 0.1 to 2.0% by mass of a linear water-soluble polyphosphate represented by the following general formula. In combination with the potassium nitrate and water-soluble polyphosphate so that the potassium nitrate / water-soluble polyphosphate (mass ratio) is 1.5 to 50, and 40 to 70% by weight of polyhydric alcohol The composition for oral cavity combined with is excellent in suppressing the sensitivity to dentine hypersensitivity, has a very high cleaning effect on tooth surface stains such as tobacco crabs, and has a good feeling during brushing, useful for preventing hypersensitivity I found out.

  That is, potassium nitrate has a dull action and is known to be incorporated into oral compositions as an active ingredient for preventing hypersensitivity, as described above, and linear water-soluble polyphosphate has been conventionally used as a tartar. It is blended in the composition for oral cavity as a component for preventing or removing dental stains (Patent Document 5: JP-A-9-175966, Patent Document 6: JP-A-11-343220, Patent Document 7: JP 2000-281549).

  Furthermore, it has already been reported that potassium nitrate and a water-soluble polyphosphate are blended into an oral composition or a dentifrice composition (Patent Document 8: JP-T 11-510161, Patent Document 9: JP-A-2004-2004). No. 10576, Patent Document 10: JP-A No. 2004-26724). Moreover, in patent document 8, although the composition which mix | blended potassium nitrate and tetra sodium pyrophosphate is disclosed (Examples 1, 2, 4), the compounding amount of tetra sodium pyrophosphate is 3.8 to 5.05%. Since the amount of water-soluble polyphosphate added to potassium nitrate is large and the feeling of use at the time of dentifrice is poor, a sufficient cleaning effect cannot be expected when used in a state having hypersensitivity. In any proposal, it is not mentioned that potassium nitrate remarkably enhances the cleaning effect of the water-soluble polyphosphate.

  In contrast, the present inventor formulated potassium nitrate and a linear water-soluble polyphosphate represented by the following general formula at a specific ratio as described above, and used a specific amount of polyhydric alcohol in combination. By combining these, surprisingly, the cleaning effect of tooth fouling derived from water-soluble polyphosphate is remarkably increased, and even if no high-concentration water-soluble polyphosphate is blended, the cleaning effect of high tooth fouling is high. In addition to being excellent in the effect of suppressing dentine hypersensitivity, users who have pain due to hypersensitivity continue during the period when the pain is reduced or eliminated Even when used as a toothpaste, it can sufficiently remove stains such as stains, plaques, meals, tobacco stains, etc. that adhere to and deposit on the tooth surface, maintain good oral hygiene, and be sensitive to dentin. Prevention, treatment effect and It was found that oral compositions which combine the cleaning effect of the surface contamination can be obtained, leading to completion of the present invention.

Accordingly, the present invention provides (A) 0.1 to 10% by mass of potassium nitrate, (B) a general formula M _{n + 2} P _n O _{3n + 1} (wherein M is Na or K, and n is an integer of 2 or more) And 0.1 to 2.0% by mass of a linear water-soluble polyphosphate represented by (A) and a mass ratio of (A) potassium nitrate / (B) water-soluble polyphosphate. The composition for oral cavity characterized by being 1.5-50 and containing 40-70 mass% of (C) polyhydric alcohol.

  The composition for oral cavity of the present invention is excellent in the prevention and treatment effect of dentine hypersensitivity, has a high cleaning effect on tooth surface stains such as tobacco spear, has a good feeling during dentifrice, It can be used effectively for prevention and treatment.

  Hereinafter, the present invention will be described in more detail. The oral composition of the present invention can be prepared as a toothpaste such as a toothpaste and a liquid toothpaste, a mouthwash, a mouthwash, and the like. Potassium nitrate, a water-soluble polyphosphate , Which contains a polyhydric alcohol at a specific ratio.

  In this invention, as potassium nitrate, the potassium nitrate normally used for the composition for oral cavity can be used, for example, Matsumoto Kosho Co., Ltd. etc. can be used. The blending amount of potassium nitrate is 0.1 to 10% by weight, preferably 3 to 7% by weight, based on the whole composition. If the blending amount is less than 0.1% by weight, the blending effect is not fully exhibited and sufficient perception is achieved. The hypersensitivity suppressing effect is not exhibited, and the cleaning effect of the tooth surface dirt is not improved, and if it exceeds 10% by mass, the bitterness is too strong to be used.

The linear water-soluble polyphosphate has a general formula M _{n + 2} P _n O _{3n + 1} (wherein M represents Na or K, n is 2 or more, preferably 2 to 4). In other words, sodium pyrophosphate having a polymerization degree n = 2 (produced by Taihei Chemical Sangyo Co., Ltd.) or potassium pyrophosphate (produced by Taihei Chemical Sangyo Co., Ltd.), tripolyphosphate having n = 3 Sodium (manufactured by Central Glass Co., Ltd.), potassium tripolyphosphate (manufactured by Taihei Chemical Industrial Co., Ltd.), n = 4 sodium tetrapolyphosphate (manufactured by Taihei Chemical Industrial Co., Ltd.), metaphosphoric acid with high polymerization degree Examples thereof include sodium (manufactured by Union Co., Ltd.) and potassium metaphosphate (manufactured by Taihei Chemical Sangyo Co., Ltd.). Of these, sodium pyrophosphate is particularly preferred from the viewpoint of the effect of removing tobacco dust. These water-soluble polyphosphates are used alone or in combination of two or more.

  The compounding quantity of water-soluble polyphosphate is 0.1-2.0 mass% of the whole composition, Preferably it is 0.5-1.5 mass%. When the blending amount of the water-soluble polyphosphate is less than 0.1% by mass, a sufficient cleaning effect cannot be obtained, and when the blending amount exceeds 2.0% by mass, the feel during use becomes uncomfortable and hypersensitive symptoms Since sufficient brushing cannot be performed in a state where the dent is present, satisfactory tooth surface dirt cleaning effect and hypersensitivity suppression effect cannot be obtained.

  Further, in the present invention, potassium nitrate and the water-soluble polyphosphate have a potassium nitrate / water-soluble polyphosphate mass ratio of 1.5 to 50, preferably 3 to 20, more preferably 5 to 10. Blend as follows. When the mass ratio of potassium nitrate / water-soluble polyphosphate is less than 1.5, a sufficient cleaning effect cannot be obtained, or the perceptual hypersensitivity suppression effect derived from potassium nitrate is inhibited, and a satisfactory hypersensitivity suppression effect cannot be obtained. If the mass ratio of potassium nitrate / water-soluble polyphosphate exceeds 50, the feel during use becomes uncomfortable, and the satisfactory effect of the present invention cannot be obtained.

  Examples of the polyhydric alcohol include sorbitol (manufactured by Towa Kasei Co., Ltd.), xylitol (manufactured by Towa Kasei Co., Ltd.), glycerin (manufactured by Daicel Chemical Co., Ltd.), propylene glycol (Dow Chemical Co., Ltd.). Etc.), polyethylene glycol (Mitsubishi Chemical Corporation, etc.) and the like. In the present invention, one or two or more kinds selected from these can be blended as polyhydric alcohols, and sorbitol, xylitol, and propylene glycol are particularly preferable. Particularly, when sorbitol, xylitol, and propylene glycol are blended in combination, high perception hypersensitivity is suppressed. Since an effect, the cleaning effect of a tooth surface dirt, and a favorable usability are acquired, it is more preferable.

  The blending amount of the polyhydric alcohol is 40 to 70% by mass of the whole composition, and 40 to 60% by mass is particularly preferred from the viewpoint of the tooth surface cleaning effect and the feeling of use during dentifrice. When the blending amount is less than 40% by mass, synergistically improved cleaning effect and hypersensitivity suppressing effect and feeling of use cannot be obtained, and the object of the present invention cannot be achieved, and exceeds 70% by mass. And it is not preferable in terms of stability of the preparation.

  In the oral cavity composition of the present invention, in addition to the above essential components, other optional components according to the dosage form can be blended. Specific examples include various abrasives, binders, thickeners, foaming agents, fragrances, sweeteners, preservatives, colorants, stabilizers, pH adjusters, and medicinal ingredients.

  As abrasives, anhydrous silicic acid, aluminum hydroxide, dibasic calcium phosphate dihydrate and anhydride, primary calcium phosphate, tertiary calcium phosphate, calcium carbonate, calcium pyrophosphate, titanium oxide, alumina, hydrated alumina, precipitated silica Other silica-based abrasives, aluminum silicate, insoluble sodium metaphosphate, insoluble potassium metaphosphate, tertiary magnesium phosphate, magnesium carbonate, calcium sulfate, bentonite, zirconium silicate, synthetic resin, etc. Species or two or more can be used. The blending amount is appropriately selected according to the form of the oral composition of the present invention, the purpose of use, and the like. For example, 10 to 50% by mass for toothpaste and 0 to 30% by mass for liquid dentifrice.

  Examples of the binder include cellulose derivatives such as hydroxyethyl cellulose, carrageenan, sodium carboxymethyl cellulose, methyl cellulose, sodium carboxymethyl hydroxyethyl cellulose, alkali metal alginates such as sodium alginate, propylene glycol alginate, xanthan gum, tragacanth gum, caraya gum, gum arabic and the like. Examples include synthetic binders such as gums, polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, polyvinylpyrrolidone, and inorganic binders such as gelling silica, gelling aluminum silica, bee gum, and laponite. 1 type (s) or 2 or more types can be used. The blending amount is appropriately selected according to the form of the oral composition of the present invention, the purpose of use and the like. For example, 0.1-5 mass% can be mix | blended with a toothpaste, and 0-5 mass% can be mix | blended with a liquid dentifrice and a mouthwash.

  As the thickener, in addition to at least one selected from those other than the above polyhydric alcohols such as maltitol and lactitol, 1,3-butylene glycol, polypropylene glycol, ethanol, modified ethanol, sugar Alcohol-reduced starch saccharified products and the like can be used. The blending amount is appropriately selected according to the form of the oral composition of the present invention, the purpose of use and the like.

  As the foaming agent, an anionic surfactant, a nonionic surfactant, a cationic surfactant, and an amphoteric surfactant can be blended. Anionic surfactants include sodium alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, sodium N-acyl sarcosine such as sodium N-lauroyl sarcosine, sodium N-myristoyl sarcosine, sodium dodecylbenzenesulfonate, hydrogenated coconut fatty acid N-acyl glutamate such as sodium monoglyceride monosulfate, sodium lauryl sulfoacetate, sodium N-palmitoyl glutamate, sodium N-methyl-N-acyl taurate, sodium N-methyl-N-acylalanine, sodium α-olefin sulfonate Is mentioned. Nonionic surfactants include sugar alcohol fatty acid esters such as sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sucrose fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyethylene glycol Polyhydric alcohol fatty acid ester such as fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene alkylphenyl ether, ether type activator such as polyoxyethylene hydrogenated castor oil, diethanolamine laurate And fatty acid alkanolamides such as Examples of the cationic surfactant include alkyl ammonium and alkyl benzyl ammonium salts. Examples of amphoteric surfactants include betaine acetate, imidazolinium betaine, and lecithin. These surfactants can be used alone or in combination of two or more thereof, and the blending amount thereof is appropriately selected according to the form of the oral composition of the present invention, the purpose of use and the like. For example, 0 to 10% by mass can be added to the toothpaste, and 0 to 5% by mass can be added to the liquid dentifrice and mouthwash.

  Examples of sweeteners include saccharin sodium, xylitol, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, perilartine, thaumatin, aspartylphenylalanine methyl ester, p-methoxycinnamic aldehyde, sucrose, lactose, fructose, sodium cyclamate, etc. 1 type (s) or 2 or more types can be mix | blended. The blending amount is appropriately selected according to the form of the oral composition of the present invention, the purpose of use and the like.

  Examples of the preservative include methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, butyl paraoxybenzoate, sodium benzoate, lower fatty acid monoglyceride, and the like, and one or more of these may be used. it can. The blending amount is appropriately selected according to the form of the oral composition of the present invention, the purpose of use and the like.

  Examples of the stabilizer and the pH adjuster include citric acid, malic acid, lactic acid, tartaric acid, acetic acid, phosphoric acid, glycerophosphoric acid, carbonic acid and various salts thereof, sodium hydroxide, sodium hydrogen carbonate, and the like.

  Perfumes include peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie Natural fragrances such as oil, coconut oil, Iris concrete, absolute peppermint, absolute rose, orange flower, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, Powdered fragrance etc.) and menthol Carvone, anethole, cineol, methyl salicylate, synamic aldehyde, eugenol, 3-l-mentoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted paramentan 3-carboxamide, pinene, octylaldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, Hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, ethyl Oral compositions such as single flavors such as thioacetate, and other flavors such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, etc. It can be used in combination with known perfume materials used in the above. The blending amount is appropriately selected according to the form of the oral composition of the present invention, the purpose of use and the like.

  Various active ingredients include alkali metal monofluorophosphates such as sodium monofluorophosphate, fluorides such as sodium fluoride, potassium fluoride, stannous fluoride, strontium fluoride, potassium salt of orthophosphoric acid, sodium Water-soluble phosphate compounds such as salts, allantoinchlorohydroxyaluminum, hinokitiol, ascorbic acid, lysozyme chloride, glycyrrhizic acid and its salts, sodium chloride, tranexamic acid, epsilon aminocaproic acid, dl-tocophenol acetate, α-bisabolol, isopropylmethyl Phenol, chlorohexidine salts, triclosan, biosol, cetylpyridinium chloride, azulene, glycyrrhetinic acid, copper chlorophyllin sodium, copper gluconate and other copper compounds, aluminum lactate, chloride Trontium, berberine, hydroxamic acid and derivatives thereof, zeolite, dextranase, glucanase such as mutanase, amylase, methoxyethylene, maleic anhydride copolymer, polyvinylpyrrolidone, epidihydrocholesterin, benzethonium chloride, dihydrocholesterol, trichlorocarbani Examples thereof include extracts of Lido, zinc citrate, soft sugar beet extract, buckwheat extract, clove, rosemary, ougon, safflower and the like. In addition, the said active ingredient can be mix | blended in an effective amount in the range which does not prevent the effect of this invention.

  As the colorant, Blue No. 1, Yellow No. 4, Green No. 3, titanium dioxide and the like can be blended in usual amounts.

  The material in particular of the container which accommodates the composition for oral cavity of this invention is not restrict | limited, Usually, the container used for the composition for oral cavity can be used. Specifically, plastic containers such as polyethylene, polypropylene, polyethylene terephthalate, and nylon can be used.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, the blending amount is mass%.

Examples and comparative examples
Dentifrice compositions having the compositions shown in Tables 1 and 2 below were prepared by the following production method.
Manufacturing method:
(I) A phase was prepared by mixing and dissolving water-soluble components (excluding binder, propylene glycol, etc.) in purified water at room temperature.
(Ii) A phase B in which a binder was dispersed at room temperature in propylene glycol was prepared.
(Iii) B phase was added and mixed in A phase under stirring, and C phase was prepared.
(Iv) In the C phase, ingredients other than water-soluble ingredients such as fragrances, abrasives, and surfactants are mixed at room temperature using a 1.5 L kneader (manufactured by Ishiyama Institute), defoamed under reduced pressure, and dentifrice The agent composition 1.2kg was obtained. In addition, regarding the dentifrice composition which does not have propylene glycol in a composition, a binder can be added and mixed with the A phase under stirring, and C phase can be prepared.

  The following methods were used to evaluate the effect of removing tobacco dust, the feeling of use during tooth brushing, and the effect of suppressing hypersensitivity. The results are shown in Tables 1 and 2.

(1) Tobacco spider removal effect test method Tobacco spear adhering hydroxyapatite pellet preparation method:
The surface of the hydroxyapatite pellets (Pentax, diameter 7 mm × thickness 3.5 mm) was treated with sand blasting, and then washed with an ultrasonic cleaner in a neutral detergent solution. The surface was etched with a 30% aqueous phosphoric acid solution (for 10 minutes), washed with water, and naturally dried. After measuring the Lab value (L0) of the pellet before adhering tobacco tobacco, after the tobacco tobacco (Peace JT (Nippon Tobacco Co., Ltd.)) burned out, suction was stopped and left for 3 minutes. The operation was repeated 3 times). After drying at 100 ° C. for 1 hour and allowing to cool, it was immersed in a 37 ° C. water bath for 3 hours. After washing with water, it was dried at 150 ° C. for 3 hours. After standing to cool, it was lightly brushed 20 times with a toothbrush (flat cut), the surface moisture was removed, and the Lab value (L1) of the pellet after the tobacco dust adhered was measured.

Tobacco crab removal effect evaluation method:
Tobacco crab-attached hydroxyapatite pellets prepared by the above method are immersed for 15 minutes in toothpastes of the compositions shown in Tables 1 and 2 and then the surface is lightly brushed with a toothbrush (flat cut) 20 times. The Lab value (L2) was measured. The tobacco removal rate was obtained from the following equation.
Tobacco dust removal rate (%) = [(L2-L1) / (L0-L1)] × 100

Tobacco crab removal effect evaluation criteria:
Evaluation was made according to the following criteria from the removal rate of tobacco tar.
◎: Tobacco dust removal rate 15% or more ○: Tobacco dust removal rate 10% or more and less than 15% △: Tobacco dust removal rate 5% or more and less than 10% ×: Tobacco dust removal rate less than 5%

(2) Usability evaluation method during dentifrice Test method:
Using 10 subjects, about 1 g of each toothpaste of the compositions shown in Tables 1 and 2 shown in Tables 1 and 2 was taken on a toothbrush, and unpleasant tastes such as bitterness and astringency when a toothpaste was performed for 3 minutes, and a sense of discomfort such as astringency. Was evaluated according to the following criteria.

Evaluation criteria:
(Score)
1 point: unpleasant taste such as bitterness and astringency, strong feeling of astringency, etc. 2 points: unpleasant taste such as bitterness, astringency, etc. 3 feels an uncomfortable feeling such as astringency, etc. 3 points: an unpleasant taste such as bitterness and astringency, Does not feel a sense of incongruity (evaluation criteria)
◎: Average point 2.5 points or more and 3 points or less ○: Average point 2 points or more and less than 2.5 points △: Average point 1.5 points or more and less than 2 points ×: Average point 1 point or more and less than 1.5 points

(3) Perceptual hypersensitivity inhibitory effect test method Test method:
Using a control product of the following composition in advance, a panel of patients with hypersensitive hypersensitivity who had a very strong pain at the time of water rinsing after brushing (10 ° C) and could not be rinsed: The effect of improving hypersensitivity was evaluated according to the standards and methods. In addition, the pain before the start of the test was 1 point in the following pain evaluation criteria in all panels.
70 people with hypersensitivity who meet the above-mentioned conditions were grouped into 14 groups of 5 each, and toothpastes of each composition of Examples and Comparative Examples shown in Tables 1 and 2 were twice a day (when waking up, At the time of going to bed), it was used for 1 week, and the pain at the time of water rinsing (10 ° C.) after 1 week was evaluated according to the following criteria.

Control product composition:
A Potassium nitrate-
B Sodium pyrophosphate-
C Sorbitol (70%) (Towa Kasei Co., Ltd.) 45
Xylitol (Towa Kasei Co., Ltd.) 10
Propylene glycol (Dow Chemical Co., Ltd.) 3
Thickening silica 5
Xanthan gum 1
Cetylpyridinium chloride 0.02
Amorphous silica 10
Sodium lauryl sulfate 1.2
Sodium fluoride 0.21
Fragrance 0.6
Blue No. 1 0.01
Purified water remaining
Total 100%

Pain assessment criteria:
(Score) 1 point: Very painful
2 points: Very painful
3 points: Somewhat painful
4 points: Slightly painful
5 points: No pain at all (evaluation criteria) ◎: Average score 4 or more and 5 or less
○: Average score of 3 points or more and less than 4 points
Δ: Average score of 2 or more and less than 3
X: Average point 1 point or more and less than 2 points

（＊）；配合量は純分で計算

(*); Compounding amount calculated as pure

A: Potassium nitrate (Matsumoto Kosho Co., Ltd.)
B: Sodium pyrophosphate (manufactured by Taihei Chemical Industry Co., Ltd.)
Sodium tripolyphosphate (Central Glass Co., Ltd.)
C: Sorbitol (70%) (manufactured by Towa Kasei Co., Ltd.)
Xylitol (Towa Kasei Co., Ltd.)
Glycerin (Daicel Chemical Co., Ltd.)
Propylene glycol (Dow Chemical Co., Ltd.)
Polyethylene glycol 400 (Mitsubishi Chemical Corporation)

（＊）；配合量は純分で計算

(*); Compounding amount calculated as pure

  From Tables 1 and 2, a dentifrice composition (Examples 1 to 10) containing a specific amount of potassium nitrate and a linear water-soluble polyphosphate in a specific ratio and a specific amount of polyhydric alcohol, All of the effect of removing tobacco dust, the feeling of use during dentifrice, and the effect of suppressing hypersensitivity were good. On the other hand, in Comparative Examples 1-4, sufficient effect was not exhibited in any one of the tobacco dust removal effect, the feeling of use at the time of dentifrice, and the hypersensitivity suppression effect.

Furthermore, in the results shown in Table 1, Example 1 in which sodium pyrophosphate was blended as the B component was superior in terms of the effect of removing tobacco dust, compared to Example 2 in which sodium tripolyphosphate was blended. It was confirmed that sodium acid was more preferable.
Moreover, Example 1 which mix | blended sorbitol, xylitol, and propylene glycol as C component compared with Example 3 which mix | blended sorbitol, glycerin, propylene glycol, Example 4 which mix | blended sorbitol, xylitol, and polyethylene glycol 400, It was confirmed that it was excellent in the effect of removing tobacco dust and the feeling during use in dentifrice, and the combination of sorbitol, xylitol, and propylene glycol was more preferable as the C component.
Regarding the blending amount and blending ratio of the A component and the B component, Example 1 in which the blending amount of the potassium nitrate of the A component is 5% and the blending ratio of the potassium nitrate of the A component and the sodium pyrophosphate of the B component is 5 is perception. Example 5 in which the sensitivity of suppressing hypersensitivity, the effect of removing tobacco dust, and the feeling of use at the time of dentifrice are all ◎, but the blending ratio of potassium nitrate is 2% and the blending ratio of potassium nitrate and sodium pyrophosphate is 2, The effect of enhancing the removal effect of sodium pyrophosphate derived from sodium pyrophosphate is not observed as much as in Example 1, the removal effect of tobacco stain is ○, and the amount of potassium nitrate added to the whole composition is also small, so the hypersensitivity suppression effect is also ○. In Example 6, the B component sodium pyrophosphate content is 1%, the A component potassium nitrate content is 10%, the (A) / (B) ratio is 10, and the potassium nitrate content relative to sodium pyrophosphate is 10%. Is moderate, so the action of potassium nitrate to enhance the removal effect of tobacco pyrogen derived from sodium pyrophosphate was demonstrated satisfactorily, and the removal effect of tobacco stain was ◎, but the ratio of potassium nitrate to the whole composition is larger, so at the time of dentifrice The feeling of use and the effect of suppressing hypersensitivity were also good. From these facts, in order to satisfactorily exert the perceptual hypersensitivity suppression effect by potassium nitrate, the blending amount greatly influences, and even if blended more than necessary, it is difficult to exert a sufficient effect. Furthermore, pyrophosphate by potassium nitrate It was confirmed that the compounding amount and the compounding ratio of potassium nitrate and sodium pyrophosphate have an effect on the enhancing effect of the removal effect of the sodium-derived tobacco crab.

  In Example 7, the B component sodium pyrophosphate content is 0.1%, the A component potassium nitrate content is 5%, and the (A) / (B) ratio is 50, with respect to the A component potassium nitrate. Since the amount of sodium pyrophosphate in component B was small, the effect of removing tobacco dust was good. In Example 8, the blending amount of sodium pyrophosphate as the B component was 2%, the blending amount of potassium nitrate as the A component was 5%, and the ratio (A) / (B) was 2.5. Although the removal effect was satisfactorily exhibited, the amount of sodium pyrophosphate blended relative to the overall composition was large, so that the feeling during use during dentifrice was ◯.

  In Examples 9 and 10, since the blending amount of the polyhydric alcohol of component C is as large as 65.0%, the same composition as in Example 9 except that the blending amount of the polyhydric alcohol is 44.5%. In Example 1, the effect of suppressing hypersensitivity, the effect of removing tobacco dust, and the feeling of use at the time of dentifrice are all ◎, while Example 9 and Example 10 have the effect of removing tobacco dust and the feeling of use. Thus, it was confirmed that when an excessive amount of the C component polyhydric alcohol was blended more than necessary, the enhancement effect of the removal effect of potassium pyrophosphate derived from sodium pyrophosphate by potassium nitrate tends to be insufficiently exhibited.

On the other hand, in Comparative Example 1 in which the A component was not blended and in Comparative Example 2 in which the B component was not blended, either the hypersensitivity suppressing effect or the tobacco dust removing effect was x. In Comparative Example 3, the blending amount of potassium nitrate in the A component is 5%, the blending amount of sodium pyrophosphate in the B component is 5%, and the (A) / (B) ratio is 1. Although the removal effect was high, it was confirmed that the feeling of use at the time of brushing was very poor and the effect of suppressing hypersensitivity derived from potassium nitrate was not satisfactorily exhibited. Further, in Comparative Example 4 in which the blending amount of the C component is as small as 37.5%, the blending ratio of the components (A) and (B) is the same, and only the blending amount of the C component is different. It was confirmed that the effects of suppressing hypersensitivity, the effect of removing tobacco dust, and the feeling of use were all inferior.
From these results, it was possible to confirm a synergistic effect and a remarkable action effect by adopting the configuration of the present invention.

Claims (1)

(A) potassium nitrate 0.1 to 10 mass%, the table in (B) formula _{M n + 2 P n O 3n} + 1 ( wherein, M is Na or K, n is an integer of 2 or more.) Containing 0.1 to 2.0% by mass of the linear water-soluble polyphosphate, and the mass ratio of (A) potassium nitrate / (B) water-soluble polyphosphate is 1.5 to 50 Yes, (C) 40-70 mass% of polyhydric alcohol is contained, The composition for oral cavity characterized by the above-mentioned.