WO2022004598A1

WO2022004598A1 - Patch for teeth

Info

Publication number: WO2022004598A1
Application number: PCT/JP2021/024169
Authority: WO
Inventors: 翔吾小宮山; 徹也吉岡
Original assignee: 株式会社サンギ
Priority date: 2020-06-29
Filing date: 2021-06-25
Publication date: 2022-01-06

Abstract

The present invention addresses the problem of providing a patch which is for teeth, with which an unpleasant feeling in an oral cavity can be suppressed, and which has a favorable feeling of use and excellent fitting properties. This patch for teeth contains a water-soluble gel as a base, an effective component for oral cavity care, and bubbles. This method for producing a patch for teeth includes adding an effective component for oral cavity care to an aqueous solution in which a water-soluble gel is dissolved, stirring and foaming the resultant, and then cooling and solidifying the resultant.

Description

Tooth patch

The present invention relates to a patch for teeth and a method for producing the same.

Conventionally, a film-shaped tooth patch for oral care such as tooth whitening and remineralization has been known. Various products have been developed for such tooth patches because they can be easily used by the user himself and can stay in the oral cavity for a relatively long time. As a patch for teeth of this type, a technology in which various active ingredients and medicinal ingredients for the purpose of oral care are contained in a film-shaped base, and a layer containing various active ingredients and medicinal ingredients are formed on a support. Various proposals have been made (see Patent Documents 1 to 4).

The product for attaching a tooth described in Patent Document 1 uses a fibroin film or a sheet as a poorly water-soluble support, on which a layer of an oral care composition containing an oral care active ingredient is formed. The strip described in Patent Document 2 is a film containing a phosphate whitening agent and a water-soluble or water-dispersible polymer system, and the dental adhesive film described in Patent Document 3 is a water-soluble or swellable supporting substance and a support material thereof. It is a film made of an active compound incorporated therein. Further, the patch for adhering to a tooth or a peripheral portion of a tooth described in Patent Document 4 is composed of a drug layer that transmits a drug to the tooth and a support layer containing a water-soluble polymer and a water-insoluble polymer together. However, since the strip described in Patent Document 2 and the dental adhesive film described in Patent Document 3 are both film-shaped and thin, they are surely torn or torn when stretched to make contact with the gap between teeth. I couldn't get it in contact with my teeth. In addition, these film-shaped tooth patches are applicable to the back teeth or the entire tooth because most of the products are within the range visible to others, that is, the size is such that the upper and lower sides can cover approximately 6 to 8 front teeth. Was difficult. Further, when considering application to the entire tooth, it is difficult to maintain the dosage form with a thin shape such as a film, and an appropriate thickness is indispensable for maintaining the dosage form. However, in the shape with increased thickness, the volume becomes large, so when the tooth patch is applied to the oral cavity, a strong foreign body feeling is generated, and it becomes painful to continue to wear it in the oral cavity. The problem stands out. In addition, since commercially available tooth patches generally have a dry film shape, they have poor adhesion when applied to teeth, and oral care is provided because a gap is created between the base material and the teeth. It was difficult for the ingredients intended for this to penetrate the entire tooth. On the other hand, the tooth-attaching product described in Patent Document 1 and the patch described in Patent Document 4 are provided with a support, so that the product can be pressed against the tooth in order to push the pharmaceutical product into the gap between the teeth. Since it is not elastic, it is difficult to make contact with the gap between the teeth and along the surface of the tooth, and since it has a support that is insoluble in water, the support remains in the oral cavity after use, which causes discomfort and is also used. It was inconvenient to have to take out the support left behind.

Japanese Unexamined Patent Publication No. 2007-169181 Special Table 2009-521396 Gazette Japanese Patent Publication No. 2004-536032 Special Table 2018-532712 Gazette

The present invention solves the above-mentioned problems, and an object of the present invention is to provide a tooth patch that can suppress discomfort in the oral cavity, has a good usability, and is excellent in wearability.

The present inventors have started to study a tooth patch that has a good usability and is easy to adhere to teeth. Therefore, we proceeded with the development of a mouthpiece-shaped tooth patch that can be applied to the entire tooth in the oral cavity, and applied a thick mouthpiece-shaped water-soluble patch made of an aqueous gel to all upper and lower teeth. did. As a result, the feeling of close contact with the tooth surface including the gap between the teeth was improved to some extent, but the large volume of the pharmaceutical product caused discomfort due to a strong foreign body feeling, and the patch was applied to the mouth even for a few minutes. Was difficult to maintain. Therefore, as a result of further studies, a water-soluble gel was used as a base, and an oral care active ingredient was contained therein, and bubbles were formed in the water-soluble gel containing the oral care active ingredient to form a tooth patch. It was found that even if the thickness of the gel is increased, it is easy to come into contact with the teeth because of its elasticity, it is easy to dissolve and remove it, and even if the volume is the same, the specific gravity can be lightened, so that the feeling of foreign matter can be reduced. With such a tooth patch, even if it is molded into the shape of a mouthpiece, it does not feel a foreign substance and has a good usability, and can have excellent adhesion to teeth. Further, since this tooth patch has self-sustaining property, it is possible to produce a tooth patch having various shapes as well as a mouthpiece shape, and even if it is in the form of a film, it has appropriate strength unlike the conventional one. It was possible to produce a patch for teeth having an excellent feeling of use while having the above. The present invention is thus completed.

That is, the present invention is specified by the following matters.
(1) A tooth patch containing a water-soluble gel as a base, an active ingredient for oral care, and containing air bubbles.
(2) The tooth patch according to (1) above, which has a specific gravity of 0.1 to 1.4.
(3) The tooth patch according to (1) or (2) above, wherein the active ingredient for oral care contains calcium phosphate.
(4) The tooth patch according to any one of (1) to (3) above, wherein the calcium phosphate is hydroxyapatite or tricalcium phosphate.
(5) The tooth patch according to any one of (1) to (4) above, which is characterized by having a mouthpiece shape.
(6) A method for producing a patch for teeth, in which an active ingredient for oral care is added to an aqueous solution in which a water-soluble gel is dissolved, the mixture is stirred and foamed, and then cooled and solidified.
(7) The method for producing a tooth patch according to (6) above, wherein the cooling is refrigeration or freeze-drying.

The present invention can provide a patch for teeth that can suppress discomfort in the oral cavity, has a good usability, and is excellent in wearability. Further, it is possible to provide a patch for teeth having excellent adhesion to teeth.

FIG. 1 is a diagram showing a state in which a mouthpiece-shaped tooth patch, which is an embodiment of the tooth patch of the present invention, is attached to a tooth. FIG. 2 is a view of the mouthpiece-shaped tooth patch of FIG. 1 as viewed from above.

The tooth patch of the present invention is based on a water-soluble gel, contains an active ingredient for oral care, and contains air bubbles. The patch for teeth of the present invention is applied to a tooth (including a peripheral portion or a peripheral tissue of the tooth) and is used for infiltrating the oral care active ingredient into the tooth. The water-soluble gel in the present invention is not particularly limited as long as it is a water-soluble gel, regardless of its properties, type, origin, etc., but for example, gelatin, pectin, pullulan, carrageenan, tamarind, gum arabic, arabinogalactan, etc. Examples thereof include gelling agents such as curdlan, tragant gum, gellan gum, carrageenan gum, and locust bean gum. Gels made from these gelling agents are preferable because they are materials that dissolve or disintegrate when contained in the mouth. These gelling agents may be used alone or in combination of two or more. Among these, gelatin is preferable because of its ease of manufacture, the tactile sensation of the patch, the hardness, and the shape retention.

The content of the gelling agent in the tooth patch of the present invention is preferably 0.05 to 15.0% by mass in terms of solid matter with respect to the entire tooth patch after molding (after solidification), and 0. 5 to 10.0% by mass is more preferable, and 1.0 to 6.0% by mass is further preferable. When the content of the gelling agent is within the above range, it has an appropriate viscosity that is easy to stir and easily contains air bubbles when aerated during the manufacturing process of the tooth patch, and it is not too hard and not too soft after aeration. Molding is possible easily. If it is used beyond this range, it may not gel, or the viscosity of the raw material after aeration may increase excessively and become too hard, which may make molding difficult. In addition, even if it can be molded, it has excessive elasticity and feels like rubber, and the texture is deteriorated. The amount of saliva in the mouth may not sufficiently dissolve the pharmaceutical product, and the feeling of use may be significantly reduced.

The water content of the tooth patch of the present invention is preferably 0 to 70.0% by mass, more preferably 0 to 60.0% by mass, based on the entire molded (solidified) tooth patch. It is more preferably 0 to 30.0% by mass. The water content is closely related to the specific gravity of the tooth patch, and a lower value is preferable in order to suppress the feeling of foreign matter in the oral cavity. Further, from the viewpoint of stability, it is necessary to devise a method to prevent evaporation when the tooth patch has a large water content, and it is preferable that the tooth patch has a smaller water content and is almost dry without such a problem. If the water content exceeds this range, it may not solidify or become a viscous liquid, or even if solidified, it may be strong enough to be easily chewed by the teeth and may not be suitable for oral use.

The oral care active ingredient in the present invention is not particularly limited as long as it is generally used as an oral care active ingredient. , Whitening agent, caries prevention and / or repair agent, hypersensitivity prevention and / or suppressant, halitosis prevention, removal and / or concealing agent, calculus prevention and / or ameliorating agent, periodontal disease prevention and / or ameliorating agent And so on. These oral care active ingredients may be used alone or in combination of two or more. Examples of the remineralization accelerator include calcium phosphate such as hydroxyapatite and tricalcium phosphate.

The content of the oral care active ingredient contained in the tooth patch of the present invention is particularly limited as long as it can exhibit various effects such as operability at the time of manufacture, viscosity of the patch, elasticity and shape retention. However, it can be used within the range stipulated by laws such as the Pharmaceuticals and Medical Devices Act. In the case of calcium phosphate remineralization accelerators such as hydroxyapatite and tricalcium phosphate, the content thereof can be preferably 0.05 to 35.0% by mass with respect to the entire tooth patch, and the content of sodium polyphosphate or the like can be preferably exemplified. In the case of a whitening agent, the content thereof is preferably 0.05 to 12.0% by mass based on the entire tooth patch. As the oral care active ingredient in the present invention, the combined use of these is preferable. Especially for patches intended for whitening and remineralization, the content of hydroxyapatite is in the range of 5.0 to 10.0% by mass, and the content of sodium polyphosphate is in the range of 0.1 to 3.0% by mass. Is more preferable in combination with.

The tooth patch of the present invention may contain ingredients other than the active ingredient for oral care in the base of the water-soluble gel. The other components are not particularly limited as long as they are components generally used in the oral cavity, and examples thereof include sweeteners and flavors. The sweetener is not particularly limited, but sugar alcohols, which are non-cariogenic materials, are preferable, and examples thereof include maltitol, xylitol, erythritol, lactitol, mannitol, sorbitol, reduced maltose starch syrup, and reduced starch syrup. Can be done. These sweeteners may be used alone or in combination of two or more. The quality may be food, food additive, pharmaceutical additive, or Japanese Pharmacopoeia, and the form may be powder, crystalline, granular, slurry, liquid, etc. It can be used regardless. Above all, it is preferable to use powdered maltitol having a sweetness close to that of sucrose and having a mild and mellow aftertaste. The content of the other components is not particularly limited as long as it can exhibit various effects such as operability at the time of manufacturing, viscosity of the patch, elasticity and shape retention, and for example, in the case of sugar alcohols, it is not limited. The content thereof is preferably 10.0 to 90.0% by mass, more preferably 20.0 to 60.0% by mass, and 30.0 to 50.0% by mass with respect to the entire tooth patch. % Is more preferable.

The tooth patch of the present invention is applied to a tooth (including a tooth peripheral part or a peripheral tissue) and is used for infiltrating an oral care active ingredient into the tooth. Since the patch for teeth of the present invention contains air bubbles, it maintains a certain formability at room temperature and can be applied to the back teeth. In addition, it has appropriate elasticity, dissolution time in the oral cavity, adhesion to teeth, and the like. In addition, the tooth patch of the present invention is excellent in wearability in the oral cavity because it can have an appropriate specific density by containing air bubbles. The specific gravity of the tooth patch of the present invention is preferably 0.1 to 1.4, more preferably 0.2 to 1.0. The specific gravity of the tooth patch in the present invention is the ratio of the mass of the tooth patch to the mass of pure water when the mass of the tooth patch of the same volume and the mass of pure water are compared. Here, pure water is mainly water from which most of impurities such as water-soluble chemical substances such as inorganic substances, organic substances and salts, fine particles such as iron rust and sand, and microorganisms such as bacteria, algae and fungi have been removed. Indicates that there is. The purification method for removing these is not particularly specified, and RO water, distilled water, and ion-exchanged water (demineralized water) fall under this category, and are collectively referred to as pure water. The amount of air bubbles in the tooth patch of the present invention is not particularly limited as long as the tooth patch has elasticity and solubility suitable for use in the oral cavity, but the specific gravity of the tooth patch is limited. It is preferably within the above range. The tooth patch of the present invention contains air bubbles to reduce the specific gravity, so that the feeling of foreign matter can be suppressed as much as possible and can be held in the mouth for a long time even if the amount of the pharmaceutical product can cover the back teeth or the entire tooth. The wearability can be easily improved. Further, by adjusting the elasticity of the base material by controlling the specific gravity and the content of air bubbles, the adhesion and solubility between the base material and the teeth can be easily improved. As a result, the active ingredient contained in the dental patch can be reliably and effectively permeated into the teeth. Furthermore, it tends to have appropriate hardness and smoothness at room temperature, and in addition, the inclusion of saliva in the mouth can increase the viscosity. Therefore, even if the patch is shaped like a mouthpiece that occupies a large volume in the mouth during use, it can be used while being in close contact with the entire tooth without any discomfort or foreign matter, so that the patch can be shaped like a mouthpiece. .. Further, even if it has a plate-like shape such as a film, it can be brought into close contact with the teeth without any discomfort or foreign matter. In addition, there is no need to use an insoluble base material, and since it is composed only of ingredients that are harmless to ingest, such as water-soluble gels, oral care active ingredients, sweeteners, and fragrances, there is no need to spit them out after use. After being applied to the teeth, it dissolves and allows the active ingredient to penetrate into the teeth, and the other ingredients can be used as ingested foods. The patch for teeth in the present invention refers to a patch for oral care that is attached to a tooth and permeates or supplies an active ingredient for oral care to the tooth, regardless of the classification of pharmaceuticals, quasi-drugs, foods, and the like.

The method for producing the tooth patch of the present invention is not particularly limited, and examples thereof include the following production methods. A gelling agent and an active ingredient for oral care are added to water. Add other ingredients as needed. Bubbles are generated by performing an aeration operation such as stirring in the mixed solution after addition. After that, it is molded into a predetermined shape by pouring it into a mold or the like. When the gelling agent is dissolved in water, it may be heated if necessary. If the amount of water in the mixed solution after the addition of each component becomes excessive, the water concentration may be adjusted to a predetermined value. The water concentration can be adjusted, for example, by heating the mixed solution to evaporate the water. Further, depending on the gelling agent used, a swelling operation is performed in advance. In this case, a gelling agent and, if necessary, a component other than the gelling agent are added to water to perform a swelling operation. Separately, a mixed solution containing other components not contained in the gelling agent solution is prepared. Then, by mixing these, a mixed liquid in which each component is mixed can be prepared. Further, in the gelling agent that does not require a swelling operation, all the raw materials including water may be dissolved and suspended in a predetermined amount in order for preparation. A foaming agent may be added to facilitate the generation of air bubbles. The foaming agent is not particularly limited as long as it can be used in the oral cavity, and examples thereof include a surfactant. Examples of the surfactant include sodium lauryl sulfate, alkyl glycoside, coconut oil fatty acid amide propyl betaine, sodium N-lauroyl-L-glutamate and the like. The aeration operation is preferably performed so that the specific gravity when the liquid after aeration is solidified is 0.1 to 1.4, and more preferably 0.2 to 1.0. When the aeration operation is performed as described above, it is possible to produce a patch for teeth which is excellent in moldability and contains air bubbles and has a low specific density. Therefore, for example, a tooth patch can be manufactured by molding with a mold having a shape applicable to the back teeth such as a mouthpiece and solidifying the mold.

A mouthpiece-shaped tooth patch, which is an embodiment of the tooth patch of the present invention, will be described. The shape of the mouthpiece in the present invention is not particularly limited as long as it is generally called a mouthpiece shape. An embodiment of the mouthpiece shape in the present invention will be described with reference to FIGS. 1 and 2. The mouthpiece M has a predetermined thickness t and has a substantially U-shape similar to that of a dental arch in a plan view. The mouthpiece M has elasticity because it contains air bubbles. As shown in FIG. 1, the mouthpiece M is attached between the upper and

lower teeth

5a and 6a in the oral cavity, and the mouthpiece M is deformed by clenching the upper and

lower teeth

5a and 6a to deform the upper dentition 5 and the lower part. By wrapping the entire circumference of the

teeth

5a and 6a of the side dentition 6 with the mouthpiece M, it is possible to allow the oral care active ingredient contained in the mouthpiece M to permeate the

teeth

5a and 6a. The upper surface 10 and the lower surface 20 of the mouthpiece M have a width at least in contact with the upper dentition 5 or the lower dentition 6 of the wearer, and the central portion thereof is substantially U-shaped in a plan view and is vertically oriented. It has

recesses

11 and 21 that are recessed. The

recesses

11 and 21 are provided for positioning the upper dentition 5 and the lower dentition 6 and for facilitating the penetration of the

teeth

5a and 6a into the mouthpiece M. Further, the

recesses

11 and 21 formed on the upper surface 10 and the lower surface 20 are provided independently without penetrating each other. As a result, when the mouthpiece M is attached, the mouthpiece M can be interposed between the upper dentition 5 and the lower dentition 6, and the mouthpiece M wraps around the entire circumference of the

teeth

5a and 6a and adheres to the mouthpiece M. It is held as if it were. Further, the

recesses

11 and 21 may have any shape, but more preferably, they are formed in a mortar shape having tapered surfaces 12 whose both side portions gradually narrow toward the bottom. Further, the width H of the openings of the

recesses

11 and 21 may be uniform, but more preferably, it is designed according to the width of each

tooth

5 or 6 of a general adult dentition, for example, FIG. As shown in, it is formed so as to gradually spread from the central portion to both ends of the substrate. This is to facilitate the penetration of the

teeth

5 and 6 into the

recesses

11 and 21. Further, by forming both side surfaces of the

recesses

11 and 21 in a tapered shape, each

tooth

5a and 6a presses the tapered surface 12 when the mouthpiece M is attached, so that both side surfaces of the

recesses

11 and 21 are inward. It becomes easy to tilt, and it is possible to easily wrap around the

teeth

5a and 6a. Further, by holding the mouthpiece M in close contact with the periphery of the

teeth

5a and 6a, the oral care active ingredient contained in the base of the mouthpiece M permeates the

teeth

5a and 6a. Further, the thickness t of the mouthpiece M is formed so as to gradually decrease from the central portion toward both ends, so that it becomes easier to insert the mouthpiece M into the oral cavity when the mouthpiece M is attached. There is. The thickness t of the mouthpiece M can be appropriately set, but at least it is set to such an extent that the entire circumference of the

teeth

5a and 6a can be covered by the deformation caused by the biting of the

teeth

5a and 6a.

In the mouthpiece M of the present embodiment configured as described above, when the wearer clenches the mouthpiece M with the upper and

lower teeth

5a and 6a and attaches the mouthpiece M, each tooth 5a of the upper and lower dentition 5 and the lower dentition 6 is attached. , 6a is held in the oral cavity for a predetermined time until it is dissolved while being wrapped in the mouthpiece M. Therefore, the oral care active ingredient contained in the mouthpiece M can be infiltrated into each of the

teeth

5a and 6a for a predetermined time. Further, by providing the

recesses

11 and 21 in the mouthpiece M, the

teeth

5a and 6a can be easily penetrated into the mouthpiece M, and the mouthpiece M can be easily attached to the peripheral surfaces of the

teeth

5a and 6a. Can be done. The mouthpiece M is, for example, molded by a known molding technique using molds of several sizes in advance, and by preparing molds of several sizes, it is possible to deal with a plurality of people having different tooth patterns. It is possible. Further, in this embodiment, the tooth and the patch for the peripheral portion of the tooth or the peripheral tissue are in the shape of a mouthpiece, but the shape may be a rectangular parallelepiped shape and may be deformed and used when the wearer is placed in the oral cavity. .. In this case, the

recesses

11 and 21 are formed linearly along the longitudinal direction of the central portion. The shape of the mouthpiece in the present invention is not limited to the above, and the shape of the tooth patch of the present invention is not limited to the shape of the mouthpiece.

Hereinafter, the present invention will be described in more detail with reference to examples, but the scope of the present invention is not limited to this.

[Example 1]
First, the following solutions 1 and 2 were prepared, and the prepared solutions 1 and 2 were used to prepare a patch for teeth.
(Preparation of solution 1)
4.2 g of gelatin was swelled for 20 minutes or more by adding 5 to 8 times the amount of purified water. This was completely dissolved while stirring with a hot stirrer at 60 to 70 ° C. Next, 30.0 g of powdered reduced maltose was added to the dissolved aqueous solution in small portions in a plurality of times and completely dissolved to obtain Solution 1. (Preparation of solution 2)
To 10.0 g of purified water, 0.5 g of sodium polyphosphate was added and completely dissolved. To this, 5.0 g of hydroxyapatite was added and suspended. Further, 0.5 g of a surfactant (N-lauroyl-L-sodium glutamate) was added as a foaming agent, and 0.9 g of trisodium citrate was added as a pH adjuster, and the mixture was stirred well to obtain Solution 2.
(Preparation of patch for teeth)
Solution 2 was added little by little to solution 1 with stirring, and the two solutions were completely mixed and suspended. This was stirred while being heated with a hot stirrer at 70 to 80 ° C., and evaporated until the water content reached a predetermined concentration. When the water content reached a predetermined concentration, the temperature of the hot stirrer was set to about 60 ° C., 0.3 g of fragrance was added, and the mixture was stirred with a household hand mixer for 5 seconds. This was poured into the mouthpiece-shaped molds shown in FIGS. 1 and 2 and cooled in a refrigerator at 4 ° C. for 30 minutes to harden to obtain a tooth patch.

[Example 2]
A tooth patch was prepared in the same manner as in Example 1 except that the stirring time with a hand mixer was set to 3 minutes.

[Example 3]
A tooth patch was prepared in the same manner as in Example 1 except that the amount of gelatin compounded was 1.2 g and the stirring time with a hand mixer was 7 minutes.

[Example 4]
Instead of cooling in a refrigerator at 4 ° C., a patch for teeth was prepared in the same manner as in Example 3 except that the product was frozen in a refrigerator at −80 ° C. and then the water content was almost removed by a freeze-dryer.

Table 1 shows the content of each component in the tooth patch (after molding by cooling solidification) prepared in Examples 1 to 4. The content of water (purified water) was measured by a moisture meter (Shimadzu Corporation, MOC-120H).

Samples solidified in the same manner as in Examples 1 to 4 were prepared, and the specific gravity was measured by comparing the mass with the mass of pure water of the same volume. The mass of pure water when a container having an internal dimension of 55 mm × 37 mm × 14 mm (width × length × height) was filled with pure water (distilled water) at 25 ° C. was 28.72 g (reference value). The mass of the sample having the same volume as the internal volume of the container was 41.04 g in Example 1, 23.25 g in Example 2, 11.45 g in Example 3, and 6.31 g in Example 4. Therefore, the respective specific gravities (mass of sample / mass of pure water) were determined to be 1.4 in Example 1, 0.8 in Example 2, 0.4 in Example 3, and 0.2 in Example 4. Was done.

As an evaluation from the viewpoint of usability and manufacturing of the tooth patch obtained in Examples 1 to 4, elasticity, color of the pharmaceutical product, dissolution time, foreign matter feeling in the oral cavity (wearability), adhesion to the tooth surface We examined the properties and ease of molding. The scoring method was adopted as the evaluation standard, and it was set as very good [4], good [3], a little bad [2], and bad [1]. The method for examining the dissolution time is to cut the tooth patch into a size of 20 mm × 20 mm × 10 mm (length × width × height), and use a stirrer of 35 × φ8 mm at a rotation speed of 400 rpm and 200 mL. The complete dissolution time in distilled water was used. The dissolution time of 3 minutes or more and less than 5 minutes was defined as 4, 5 minutes or more and less than 10 minutes was defined as 3, 1 minute or more and less than 3 minutes or 10 minutes or more and less than 20 minutes was defined as 2, and the others were defined as 1. The results of the evaluation are shown in Table 2.

The tooth patch of the present invention can be suitably used as a patch for applying the active ingredient for oral care to teeth. Further, it can be suitably used as a mouthpiece-shaped patch.

M Mouthpiece t Mouthpiece thickness H Concave opening width 10 Upper surface of mouthpiece 11 Upper concave surface 12 Tapered surface 20 Lower surface of mouthpiece 21 Lower concave portion 5 Upper dentition 5a Upper dentition 6 Lower dentition 6a Lower tooth

Claims

A tooth patch that uses a water-soluble gel as a base, contains an active ingredient for oral care, and contains air bubbles.
The tooth patch according to claim 1, wherein the specific gravity is 0.1 to 1.4.
The tooth patch according to claim 1 or 2, wherein the active ingredient for oral care contains calcium phosphate.
The tooth patch according to any one of claims 1 to 3, wherein the calcium phosphate is hydroxyapatite or tricalcium phosphate.
The tooth patch according to any one of claims 1 to 4, which is characterized by having a mouthpiece shape.
A method for manufacturing a tooth patch that is made by adding an oral care active ingredient to an aqueous solution in which a water-soluble gel is dissolved, stirring and foaming, and then cooling and solidifying.
The method for producing a tooth patch according to claim 6, wherein the cooling is refrigeration or freeze-drying.