KR102573530B1 - Oral cleaning composition comprising popping component - Google Patents

Oral cleaning composition comprising popping component Download PDF

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KR102573530B1
KR102573530B1 KR1020210187752A KR20210187752A KR102573530B1 KR 102573530 B1 KR102573530 B1 KR 102573530B1 KR 1020210187752 A KR1020210187752 A KR 1020210187752A KR 20210187752 A KR20210187752 A KR 20210187752A KR 102573530 B1 KR102573530 B1 KR 102573530B1
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component
popping
oral cleaning
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cleaning composition
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KR20220130566A (en
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김현진
김지은
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/11Encapsulated compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25Silicon; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/22Gas releasing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/28Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/60Particulates further characterized by their structure or composition
    • A61K2800/61Surface treated
    • A61K2800/62Coated
    • A61K2800/622Coated by organic compounds

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Birds (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

본 발명은 구강청결용 조성물에 관한 것으로, 보다 상세하게는 구강청결용 조성물에 기체가 충진된 팝핑성분이 오일로 코팅되어 캡슐 형태로 존재하는 구강청결용 조성물에 관한 것이다.
또한, 본 발명에 따르면, 구강청결용 조성물은 기체가 충진된 캡슐 형태의 팝핑성분이 구강 내에서 용융되면서 팝핑(popping) 효과를 가지므로 남녀노소, 특히 양치질에 거부반응을 일으키기 쉬운 어린 아이들의 기호에도 충족하여 국민 구강건강 및 충치예방에 따른 보험 재정에 일조할 수 있다.
The present invention relates to a composition for oral cleaning, and more particularly, to a composition for oral cleaning in which a popping component filled with gas is coated with oil to exist in the form of a capsule.
In addition, according to the present invention, the oral cleaning composition has a popping effect as the popping component in the form of a gas-filled capsule melts in the oral cavity, so it is a preference of men and women of all ages, especially young children who are prone to have a rejection reaction to brushing their teeth. can also contribute to the insurance finance according to national oral health and tooth decay prevention.

Description

팝핑 성분을 포함하는 구강청결용 조성물{Oral cleaning composition comprising popping component}Oral cleaning composition comprising a popping component

본 발명은 구강청결용 조성물에 관한 것으로, 보다 상세하게는 구강청결용 조성물에 기체가 충진된 팝핑 성분을 포함함으로써 구강 내에서 캡슐 형태로 존재하는 팝핑 성분이 용융되면서 팝핑(popping) 효과를 가지므로, 남녀노소, 특히 양치질에 거부반응을 일으키기 쉬운 어린 아이들의 기호에도 충족하여 국민 구강건강 및 충치예방에 따른 보험 재정에 일조할 수 있는 구강청결용 조성물에 관한 것이다.The present invention relates to a composition for oral cleaning, and more particularly, by including a popping component filled with gas in the composition for oral cleaning, so that the popping component present in the form of a capsule in the oral cavity melts and has a popping effect. , It relates to an oral cleaning composition that can contribute to insurance finance for national oral health and tooth decay prevention by satisfying the taste of young children, who are prone to have a negative reaction to brushing teeth.

충치는 대표적인 구강질환으로 구강내에 존재하는 세균, 특히 스트렙토코커스 뮤탄스가 대사과정에서 치아에 부착된 당분이나 전분등의 탄수화물을 분해시켜 각종 유기산을 생성시키고 이러한 산에 의해 치아의 무기질 성분이 탈회되어 유발된다고 알려져 있다. 충치를 포함한 각종 구강질환을 예방하기 위하여 불소화합물, 아미노카프론산, 클로로헥시딘, 덱스트라나제 등이 현재 이용되고 있으며, 인체에 무해한 식물추출물, 한방성분 또는 유산균을 이용한 천연 항균성분을 포함하는 구강제품들이 연구되고 있다.Tooth decay is a representative oral disease, and bacteria present in the oral cavity, especially Streptococcus mutans, decompose carbohydrates such as sugar and starch attached to teeth during the metabolic process to produce various organic acids, which are caused by demineralization of tooth minerals. It is known to be In order to prevent various oral diseases including tooth decay, fluoride compounds, aminocaproic acid, chlorhexidine, dextranase, etc. are currently being used. Oral products are being studied.

치약은 치아 및 구강 내부를 세정하기 위해 사용되는 약물성 복합물질로서, 치아의 미백, 치석 침착 예방, 구취제거 등 다양한 용도를 가지며 생필품으로 사용되고 있으며, 종래의 치약은 크림 또는 젤 형태로 만들어 졌으며, 이를 뚜껑이 달린 튜브용기에 담아 사용할 때마다 튜브에 압력을 가하여 튜브 입구로 밀려나온 치약을 사용하는 방식이 일반적이나, 튜브를 열어놓은 채 방치하면 각종 세균에 노출 될 수 있는 문제점이 있다.Toothpaste is a drug compound used to clean teeth and the inside of the oral cavity, and has various uses such as tooth whitening, tartar deposition prevention, and bad breath removal, and is used as a daily necessity. Conventional toothpaste is made in the form of cream or gel, It is common to put it in a tube container with a lid and apply pressure to the tube every time it is used to use the toothpaste pushed out of the tube inlet, but there is a problem that it can be exposed to various bacteria if left open.

이러한 문제점을 해결하고자 알약형태로 된 정제형 치약이 개발(특허출원번호 제10-2011-0083295호)된 바 있지만, 여전히 양치질에 거부반응을 일으키기 쉬운 어린 아이들의 기호에도 충족시킬 수 있는 구강 청결제 조성물의 개발이 요구된다. In order to solve these problems, a toothpaste in tablet form has been developed (Patent Application No. 10-2011-0083295), but a mouthwash composition that can satisfy the taste of young children who are still prone to rejection by brushing their teeth. development is required.

따라서, 본 발명의 발명자는 팝핑 효과를 가지는 성분을 활용하여 구강청결용 조성물을 개발함으로서, 일반인 뿐만 아니라, 특히 양치질에 거부반응을 일으키기 쉬운 어린 아이들의 기호에 충족하고, 인체에 무해하고 휴대가 용이한 구강청결용 조성물을 완성하였다.Therefore, the inventor of the present invention develops a composition for oral cleaning using a component having a popping effect, which satisfies the taste of not only the general public but also children who are prone to have a negative reaction to brushing teeth, is harmless to the human body, and is easy to carry. A mouthwash composition was completed.

한국공개특허 제10-2019-0141372호 (공개일자: 2019.12.24)Korean Patent Publication No. 10-2019-0141372 (published date: 2019.12.24)

본 발명은 상기 문제점을 해결하고자 고안된 것으로, 기체가 충진된 캡슐 형태로 존재하는 팝핑성분이 포함된 구강청결용 조성물을 제공하는 것을 목적으로 한다.The present invention has been devised to solve the above problems, and an object of the present invention is to provide a composition for oral cleaning containing a popping component present in the form of a capsule filled with gas.

상기와 같은 목적을 달성하기 위하여, 본 발명은 기체가 충진된 캡슐 형태로 존재하는 팝핑성분을 포함하는 구강청결용 조성물을 제공한다.In order to achieve the above object, the present invention provides an oral cleaning composition comprising a popping component present in the form of a gas-filled capsule.

본 발명의 일실시예에 따르면, 상기 팝핑성분은 당 성분을 포함할 수 있다.According to one embodiment of the present invention, the popping component may include a sugar component.

상기 당 성분은 자일리톨을 포함할 수 있다.The sugar component may include xylitol.

본 발명의 일실시예에 따르면, 연마제를 더 포함할 수 있으며, 상기 연마제는 이산화규소를 포함할 수 있다.According to one embodiment of the present invention, it may further include an abrasive, and the abrasive may include silicon dioxide.

상기 캡슐 형태는 상기 팝핑성분을 코코넛 오일과 분말상 유당-유지혼합물로 코팅하여 제조된 것일 수 있다.The capsule form may be prepared by coating the popping component with coconut oil and powdered lactose-fat mixture.

본 발명의 일실시예에 따르면, 상기 구강청결용 조성물은 충치를 유발하는 스트렙토코쿠스 뮤탄스 (Streptococcus mutans)의 생육을 억제하는 유산균 또는 유산균 배양물을 더 포함할 수 있다.According to one embodiment of the present invention, the oral cleaning composition may further include lactic acid bacteria or lactic acid bacteria cultures that inhibit the growth of Streptococcus mutans that cause tooth decay.

본 발명에 따르면, 구강청결용 조성물은 기체가 충진된 캡슐 형태로 존재하는 팝핑성분을 포함함으로써 구강 내에서 상기 캡슐 형태의 팝핑 성분이 용융되면서 팝핑(popping) 효과를 가지며, 추가로 충치 유발균의 생육을 유산균을 포함할 경우 충치 예방 효과를 제공하는 것이 가능하다.According to the present invention, the oral cleaning composition includes a popping component present in the form of a capsule filled with gas, so that the popping component in the form of a capsule is melted in the oral cavity to have a popping effect, and additionally, the composition for caries-causing bacteria When the growth includes lactic acid bacteria, it is possible to provide an effect of preventing caries.

이하, 본 발명에 따른 구강청결용 조성물에 대하여 본 발명의 바람직한 실시예를 상세히 설명하기로 한다.Hereinafter, preferred embodiments of the present invention will be described in detail with respect to the oral cleaning composition according to the present invention.

본 발명에 따른 구강청결용 조성물은 기체가 충진된 캡슐 형태로 존재하는 팝핑성분을 포함한다.The oral cleaning composition according to the present invention includes a popping component present in the form of gas-filled capsules.

본 발명에 있어서, '팝핑(popping)성분'이란 가스 함포 성분으로 고온고압의 조건하에 당 성분의 용융물을 교반하면서 초고압의 이산화탄소를 분사하여 용융물 중에 다량의 이산화탄소 기체를 융용 및/또는 함포시킨 후, 초고압 조건하에서 냉각 고화시켜 얻어지는 성분으로서, 구강 내에서 팝핑성분이 용융되면 용융물 내에 함포된 고압의 이산화탄소 기체가 급속히 팽창되면서 구강 내로 방출되는 과정에서 기체가 액체와 자발적으로 혼합되는 현상인, 팝핑(popping) 효과를 나타내게 되는 성분을 의미한다.In the present invention, the 'popping component' is a gas-containing component, which melts and/or contains a large amount of carbon dioxide gas in the melt by spraying ultra-high pressure carbon dioxide while stirring the melt of the sugar component under conditions of high temperature and high pressure, As a component obtained by cooling and solidifying under ultra-high pressure conditions, when the popping component is melted in the oral cavity, the high-pressure carbon dioxide gas contained in the melt rapidly expands and is released into the oral cavity, which is a phenomenon in which the gas spontaneously mixes with the liquid. ) means the ingredient that will show the effect.

본 발명에 있어서, 상기 당 성분은 기체를 충진하여 포획하는 담체의 기능을 하며, 상기 당 성분은 자일리톨(xylitol), 솔비톨(sorbitol), 말티톨(maltitol), 에리스리톨(erythritol), 환원팔라티노스, 만니톨(mannitol) 및 락티톨자일리톨로 이루어진 군으로부터 선택될 수 있으며, 바람직하게는 자일리톨일 수 있으나, 이에 제한되지 않는다.In the present invention, the sugar component functions as a carrier that fills and captures gas, and the sugar component is xylitol, sorbitol, maltitol, erythritol, reduced palatinose, and mannitol. It may be selected from the group consisting of (mannitol) and lactitol xylitol, preferably xylitol, but is not limited thereto.

상기 자일리톨은 자일로스를 가공하여 만든, 알코올계의 당으로 설탕 대용품이나 치아 관리용품에 이용되는 물질이다. 같은 질량의 자당과 같은 정도의 단맛이 나지만 칼로리는 자당의 60% 정도이다. 자당, 포도당, 과당 등의 육탄당과는 달리 자일리톨은 오탄당으로 스트렙토코쿠스 뮤탄스 (Streptococcus mutans)균이 당을 발효시키지 못해 산의 생성이 불가능하기 때문에 치아를 보호하거나 손상된 치아 표면을 복원하는데 도움을 준다. 자일리톨을 사용하면 충치예방, 치아보호, 손상된 치아복원하는데 도움을 줄 수 있다.The xylitol is an alcohol-based sugar made by processing xylose and is a substance used in sugar substitutes or dental care products. It tastes as sweet as sucrose of the same mass, but has about 60% of the calories of sucrose. Unlike hexose sugars such as sucrose, glucose, and fructose, xylitol is a pentose sugar and helps to protect teeth or restore damaged tooth surfaces because Streptococcus mutans cannot ferment sugar and produce acids. give Xylitol can help prevent tooth decay, protect teeth, and restore damaged teeth.

본 발명에 있어서 '기체'란 구체적으로 그 종류를 명확히 구분하여 지칭하지 않는 한, 이산화탄소, 산소, 질소, 헬륨 등과 같은 상대적으로 인체에 무해하거나 불활성인 기체나, 상대적으로 인체에 무해한 방향성 기체, 또는 이들의 임의의 혼합 기체를 의미한다. In the present invention, 'gas' is a relatively harmless or inert gas to the human body, such as carbon dioxide, oxygen, nitrogen, helium, etc., or a relatively harmless aromatic gas, or It means any mixed gas of these.

본 발명에 있어서 '충진'이란 구체적으로 상기의 기체가 상기의 당 성분내에 적어도 부분적으로 또는 가압 상태로 채워 넣어진 상태를 의미한다.In the present invention, 'filling' specifically means a state in which the gas is at least partially filled in the sugar component or in a pressurized state.

본 발명은 연마제를 더 포함할 수 있으며, 상기 연마제는 이산화규소, 침강 실리카, 실리카 겔, 무수규산, 지르코늄 실리케이트, 인산수소칼슘, 무수인산수소칼슘, 함수알루미나, 경질탄산칼슘, 중질탄산칼슘, 칼슘피로인산염, 불용성메타인산염 및 알루미늄실리케이트로 이루어진 군으로부터 선택될 수 있으며, 바람직하게는 이산화규소이다.The present invention may further include an abrasive, wherein the abrasive includes silicon dioxide, precipitated silica, silica gel, anhydrous silicic acid, zirconium silicate, calcium hydrogen phosphate, anhydrous calcium hydrogen phosphate, hydrous alumina, light calcium carbonate, heavy calcium carbonate, calcium It may be selected from the group consisting of pyrophosphates, insoluble metaphosphates and aluminum silicates, preferably silicon dioxide.

이산화규소는 짠맛이 없고 pH가 중성에 해당하여 구강 내 점막을 자극하지 않으므로 남녀노소를 불문하고 누구나 무난하게 사용 할 수 있는 장점이 있다.Silicon dioxide does not have a salty taste and has a neutral pH, so it does not irritate the mucous membrane in the oral cavity, so it has the advantage that anyone regardless of age or gender can use it without difficulty.

캡슐 형태의 팝핑성분은 코코넛 오일과 분말상 유당-유지혼합물로 코팅하여 캡슐 형태로 제조될 수 있으며, 보다 상세하게는 회전팬 등에 팝핑성분과 코코넛 오일과 함께 투입한 후 일정한 온도와 습도 조건 하에서 교반하여 1차 코팅시킬 수 있으며, 추가로 분말상 유당-유지혼합물을 분사하여 고르게 2차 코팅시킨 캡슐 형태의 팝핑성분을 제조할 수 있으나, 반드시 이에 한정되는 것은 아니다.The popping component in the form of a capsule can be manufactured in a capsule form by coating it with coconut oil and powdered lactose-fat mixture. More specifically, after putting the popping component and coconut oil in a rotating fan, etc. The first coating may be applied, and the powdered lactose-fat mixture may be sprayed to evenly second coat the popping component in the form of a capsule, but it is not necessarily limited thereto.

본 발명에 따른 구강청결용 조성물은 충치를 유발하는 스트렙토코쿠스 뮤탄스 (Streptococcus mutans)의 생육을 억제하는 유산균 또는 유산균 배양물을 더 포함할 수 있다.The oral cleaning composition according to the present invention may further include lactic acid bacteria or lactic acid bacteria cultures that inhibit the growth of Streptococcus mutans that cause tooth decay.

본 발명에 있어서, '유산균 배양물'이란 유산균의 배양액, 이의 무세포 상등액 또는 유산균배양건조물일 수 있으나, 이에 제한되지 않는다.In the present invention, the 'lactic acid bacteria culture' may be a culture medium of lactic acid bacteria, a cell-free supernatant thereof, or a dried product of lactic acid bacteria culture, but is not limited thereto.

상기 유산균 배양물에는 미생물이 생산하는 천연 항균물질인 박테리오신이 포함되어 있으며, 상기 박테리오신은 충치를 유발하는 스트렙토코쿠스 뮤탄스 (Streptococcus mutans)의 생육을 효과적으로 억제하는 것으로 입증되었다(한국등록특허 제10-0158048호).The lactic acid bacteria culture contains bacteriocin, a natural antibacterial substance produced by microorganisms, and the bacteriocin has been proven to effectively inhibit the growth of Streptococcus mutans , which causes tooth decay (Korean Patent No. 10 -0158048).

상기 유산균은 스트렙토코쿠스 뮤탄스 (Streptococcus mutans)의 생육을 억제하는 기능성 유산균으로 알려진, 락토바실러스 루테리(Lactobacillus reuteri)(한국등록특허 제10-1966772호), 락토바실러스 가세리(Lactobacillus gasseri)(한국등록특허 제10-2198553호), 락토바실러스 퍼멘텀(Lactobacillus fermentum)(한국등록특허 제10-2198552호), 락토바실루스 헬베티쿠스(Lactobacillus helveticus)(한국공개특허 제10-2016-0030956호) 및 락토바실러스 살리바리우스(Lactobacillus salivarius)(한국공개특허 제10-2020-0070081호)로 이루어진 군에서 선택되는 하나 이상일 수 있으며, 이에 제한되지 않는다.The lactic acid bacteria are known as functional lactic acid bacteria that inhibit the growth of Streptococcus mutans , Lactobacillus reuteri (Korean Patent No. 10-1966772), Lactobacillus gasseri ( Lactobacillus gasseri ) (Korea Registered Patent No. 10-2198553), Lactobacillus fermentum (Korean Patent No. 10-2198552), Lactobacillus helveticus (Korean Patent Publication No. 10-2016-0030956) and It may be at least one selected from the group consisting of Lactobacillus salivarius (Korean Patent Publication No. 10-2020-0070081), but is not limited thereto.

본 발명에 따른 구강청결용 조성물은 기타 첨가제로 계면활성제, 착향제, 감미제, 충치예방제인 불화나트륨 및 프로폴리스(Propolis)를 더 포함할 수 있다.The mouthwash composition according to the present invention may further include a surfactant, a flavoring agent, a sweetener, sodium fluoride and propolis as other additives.

상기 계면활성제는 음이온 계면활성제, 양이온 계면활성제, 비이온 계면활성제, 양쪽성 계면 활성제 및 쯔비터이온성 계면활성제 가운데 1종 또는 2종 이상이 선택될 수 있다.The surfactant may be one or two or more selected from anionic surfactants, cationic surfactants, nonionic surfactants, amphoteric surfactants, and zwitterionic surfactants.

상기 착향제는 페퍼민트, 스피아민트 등의 민트계열과 멘톨, 유칼립투스, 아니스, 티몰, 레몬, 라임, 커피, 녹차, 로즈마리, 쟈스민 등의 향료 가운데 1종 또는 2종 이상이 선택될 수 있으며, 이에 제한되지 않는다.The flavoring agent may be one or two or more selected from mints such as peppermint and spearmint and flavoring agents such as menthol, eucalyptus, anise, thymol, lemon, lime, coffee, green tea, rosemary, and jasmine. It doesn't work.

상기 감미제는 수크랄로스, 에리스리톨, 아스파탐 및 이들의 조합으로 이루어진 군으로부터 적어도 하나 이상이 선택될 수 있으며, 이에 제한되지 않는다.The sweetener may be at least one selected from the group consisting of sucralose, erythritol, aspartame, and combinations thereof, but is not limited thereto.

상기 프로폴리스(Propolis)는 식품의약품안전청에서 항산화작용과 구강에서의 항균작용을 기능성으로 고시하고 있는 천연 항균물질로서, 상기 구강청결용 조성물에 포함시켜, 자일리톨 및 유산균 배양물과 함께 충치를 유발하는 스트렙토코쿠스 뮤탄스(Streptococcus mutans)의 생육억제에 대해 시너지 효과를 가질 수 있으므로 우수한 구강청결용 조성물을 제공할 수 있다. Propolis is a natural antibacterial substance that is notified by the Food and Drug Administration for its antioxidant action and antibacterial action in the oral cavity as functional, and is included in the oral cleaning composition to cause tooth decay along with xylitol and lactic acid bacteria culture. Streptococcus mutans ( Streptococcus mutans ) Since it can have a synergistic effect on the growth inhibition, it is possible to provide an excellent oral cleaning composition.

실시예Example

이하, 실시예를 통하여 본 발명을 더욱 상세히 설명하고자 한다. 이들 실시예는 오로지 본 발명을 예시하기 위한 것으로서, 본 발명의 범위가 이들 실시예에 의해 제한되는 것으로 해석되지 않는 것은 당 업계에서 통상의 지식을 가진 자에게 있어서 자명할 것이다.Hereinafter, the present invention will be described in more detail through examples. These examples are only for exemplifying the present invention, and it will be apparent to those skilled in the art that the scope of the present invention is not to be construed as being limited by these examples.

제조예 1:Preparation Example 1:

구강청결용 조성물은 전체 조성물에 대해 기체가 충진된 팝핑성분 10 중량%, 이산화규소 50 중량%, 유산균배양건조물 1 중량% 및 기타 첨가제 39 중량%를 혼합하여 냉동건조 또는 열풍건조 등의 다양한 건조방식으로 건조시켜 고체 형태의 구강청결용 조성물을 제조하였다.Mouth cleaning composition is a mixture of 10% by weight of gas-filled popping component, 50% by weight of silicon dioxide, 1% by weight of lactic acid bacteria cultured dried product, and 39% by weight of other additives, based on the total composition, and mixed with various drying methods such as freeze drying or hot air drying. dried to prepare a solid oral cleaning composition.

상기 팝핑성분은 구체적으로 다음과 같은 공정을 통해 제조하였다.The popping component was specifically prepared through the following process.

먼저, 원료혼합물(당 성분 및 수성용매)을 오토클레이브에 투입하고, 스팀압력 5 kg/㎠ 및 온도 118 내지 120℃에서 18 내지 20분 동안 쿠킹한 후, 스팀압력 10 kg/㎠ 및 온도 142 내지 144℃에서 18 내지 20분 동안 진공쿠킹하여 수분을 3중량% 이하로 조절하여 당 성분의 용융물을 제조하였다.First, the raw material mixture (sugar component and aqueous solvent) was put into an autoclave and cooked for 18 to 20 minutes at a steam pressure of 5 kg/cm2 and a temperature of 118 to 120° C., and then at a steam pressure of 10 kg/cm2 and a temperature of 142 to 142 A melt of the sugar component was prepared by vacuum cooking at 144° C. for 18 to 20 minutes to adjust the water content to 3% by weight or less.

다음으로, 상술한 과정을 통해 얻어진 당 성분의 용융물에 향료와 색소를 투입시킨 다음, 재킷(jacket) 스팀압력 2 kg/㎠, 이산화탄소 기체압력 48 kg/㎠, 교반수 800 rpm의 조건하에서 4분 동안 교반시키면서 이산화탄소 기체를 혼합하였다.Next, flavorings and pigments were added to the melt of the sugar component obtained through the above process, and then the mixture was stirred for 4 minutes under the conditions of 2 kg/cm 2 jacket steam pressure, 48 kg/cm 2 carbon dioxide gas pressure, and 800 rpm stirring water. During stirring, carbon dioxide gas was mixed.

다음으로, 상술한 과정을 통해 얻어진 이산화탄소 기체가 혼합된 당 성분의 용융물을 이산화탄소 기체 압력 48 kg/㎠ 하에서 냉각관으로 이송시킨 다음, 냉각수의 온도 20±3℃, 냉각수의 순환속도 10G.P0.M. 및 이산화탄소 기체의 압력을 48 kg/㎠로 하여 냉각고화시켜 이산화탄소 기체가 충진된 팝핑성분을 생성한 후, 이산화탄소 기체를 갑자기 방출시켜 상기 냉각고화된 팝핑성분을 파편화시켰다.Next, the melt of the sugar component mixed with carbon dioxide gas obtained through the above process was transferred to a cooling pipe under a carbon dioxide gas pressure of 48 kg/cm 2 , and then the temperature of the cooling water was 20±3° C. and the circulation rate of the cooling water was 10G.P0. M. And the carbon dioxide gas was cooled and solidified at a pressure of 48 kg/cm 2 to create a popping component filled with carbon dioxide gas, and then the carbon dioxide gas was suddenly released to fragment the cooled and solidified popping component.

다음으로, 파편화된 팝핑성분을 회수하여 크기를 선별(4메쉬 이상, 20메쉬이하는 폐기함)함으로써, 본 제조예에 사용하기에 적당한 팝핑성분을 완성하였다.Next, by recovering the fragmented popping component and sorting the size (4 mesh or more, 20 mesh or less is discarded), a popping component suitable for use in this preparation example was completed.

상기 유산균배양건조물은 락토바실러스 루테리(Lactobacillus reuteri)를 MRS 액체배지에 24시간 정치배양한 배양액을 원심분리(4,000 × g, 4℃, 5분)한 후, 0.22 μm 필터를 이용하여 얻어진 제균된 상등액을 동결건조하여 완성하였다.The lactic acid bacteria cultured dried product is a sterilized supernatant obtained by centrifuging (4,000 × g, 4 ℃, 5 minutes) a culture solution obtained by stationary culture of Lactobacillus reuteri in MRS liquid medium for 24 hours, and then using a 0.22 μm filter. was completed by lyophilization.

상기 기타 첨가제로 라우릴황산나트륨 0.5 내지 2 중량%, 멘톨 착향제 0.1 내지 5 중량%, 아스파탐 0.01 내지 0.5 중량% 및 불화나트륨 0.01 내지 0.3 중량%를 포함하였다.The other additives included 0.5 to 2% by weight of sodium lauryl sulfate, 0.1 to 5% by weight of menthol flavoring agent, 0.01 to 0.5% by weight of aspartame, and 0.01 to 0.3% by weight of sodium fluoride.

제조예 2:Preparation Example 2:

상기 [제조예 1]에서 상술된 방법으로 제조된 팝핑성분을 회전팬에서 코코넛 오일과 함께 20℃ 및 45%의 습도하에서 18 rpm으로 교반하여 1차 코팅시킨 후, 20 내지 26℃에서 분말상 유당-유지혼합물을 분사하여 고르게 코팅시켜서 캡슐 형태의 팝핑성분을 제조하였으며, 그 외 제조방법은 [제조예 1]과 동일하였다.The popping component prepared by the method described in [Production Example 1] was first coated with coconut oil in a rotating pan at 18 rpm under a humidity of 20 ° C and 45%, and then lactose-powdered at 20 to 26 ° C. The oil-and-fat mixture was sprayed and coated evenly to prepare a popping component in the form of a capsule, and other manufacturing methods were the same as in [Preparation Example 1].

제조예 3:Preparation Example 3:

상기의 제조예 1 및 제조예 2에서 제조된 고체 형태의 구강청결용 조성물을 사용이 간편하도록 분말 상태, 과립 형태 또는 일정한 형상으로 성형하거나 일정한 틀에 넣어 성형물의 형태로 제조하였다. The oral cleaning compositions in solid form prepared in Preparation Example 1 and Preparation Example 2 were molded into a powder state, granular form, or a certain shape for ease of use, or put into a certain mold and prepared in the form of a molded product.

실험예Experimental Example

상기의 제조예 1 및 제조예 2에서 제조된 고체 형태의 구강청결용 조성물을 물에 넣고 탄산가스가 방출되는 시간을 측정(팝핑성분에서 기포가 발생되는 것이 육안으로 확인되는 시간)하였으며, 그 결과 캡슐 형태로 코팅된 조성물(제조예 2)이 코팅되지 않은 조성물(제조예 1)에 비해 탄산가스가 방출되는 시간이 현저하게 지속되었다. 이는 본 발명의 캡슐 형태로 코팅된 구강청결용 조성물이 양치하는 동안 구강 내에서 팝핑 효과가 지속될 수 있다는 것을 나타낸다.The solid oral care composition prepared in Preparation Example 1 and Preparation Example 2 was put into water, and the time for carbon dioxide gas to be released was measured (the time when it was visually confirmed that bubbles were generated in the popping component). The time for carbon dioxide to be released in the capsule-coated composition (Preparation Example 2) was remarkably sustained compared to the uncoated composition (Preparation Example 1). This indicates that the popping effect can be maintained in the oral cavity while the composition for oral cleaning coated in the form of a capsule of the present invention is brushing teeth.

이상으로 본 발명의 특정한 부분을 상세히 기술하였는 바, 당업계의 통상의 지식을 가진 자에게 있어서 이러한 구체적인 기술은 단지 바람직한 구현 예일 뿐이며, 이에 본 발명의 범위가 제한되는 것이 아닌 점은 명백하다. 따라서, 본 발명의 실질적인 범위는 첨부된 청구항과 그의 등가물에 의하여 정의된다고 할 것이다.Having described specific parts of the present invention in detail above, it is clear that these specific techniques are only preferred embodiments for those skilled in the art, and the scope of the present invention is not limited thereto. Accordingly, the substantial scope of the present invention will be defined by the appended claims and equivalents thereof.

Claims (4)

방향성 기체가 충진된 팝핑성분을 포함하며,
상기 팝핑성분은 적어도 1차 이상의 코팅된 캡슐 형태로 존재하며,
상기 1차 코팅은 오일로 코팅된 것을 특징으로 하는 구강청결용 조성물.
It includes a popping component filled with aromatic gas,
The popping component exists in the form of at least one or more coated capsules,
The primary coating is an oral cleaning composition, characterized in that coated with oil.
제1항에 있어서,
상기 팝핑성분은 당 성분을 포함하는 것을 특징으로 하는 구강청결용 조성물.
According to claim 1,
The popping component is an oral cleaning composition, characterized in that it contains a sugar component.
제2항에 있어서,
상기 당 성분은 자일리톨을 포함하는 것을 특징으로 하는 구강청결용 조성물.
According to claim 2,
The sugar component is an oral cleaning composition, characterized in that it comprises xylitol.
제1항에 있어서,
충치를 유발하는 스트렙토코쿠스 뮤탄스 (Streptococcus mutans)의 생육을 억제하는 유산균 또는 유산균 배양물을 더 포함하는 것을 특징으로 하는 구강청결용 조성물.
According to claim 1,
Oral cleaning composition characterized in that it further comprises a lactic acid bacteria or lactic acid bacteria culture that inhibits the growth of Streptococcus mutans, which causes tooth decay.
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