KR102055667B1 - Toothpsate composites type gel tablet and that of manufacturing method - Google Patents

Abstract

The present invention relates to a jelly tablet toothpaste composition and a method for producing the same, the composition is 12.13% by weight of sorbitol, 10% by weight of silicon dioxide, 0.05% by weight of pyridoxine hydrochloride, 0.22% by weight of sodium fluoride, 1% by weight of sodium pyrophosphate, Sodium sulphate 3% by weight, enzyme-treated stevia 1.20% by weight, ascorbic acid 0.50% by weight, apple mint flavor powder 1% by weight, camphor 1.50% by weight, MP (methyl paraben) 0.10% by weight, peppermint oil 2% by weight, gum arabic 4 It is formed by mixing the formulation of the wt%, 57% by weight of furan and 1.30% by weight of gardenia blue pigment to form a formulation using a metal casting mold and coating the formulation formed by using 5% by weight of xylitol and then dried. do,
Accordingly, it is formed by coating powder using HPMC mixture used for tablet medicine after perforating powder in the casting mold in the shape of the formulation. It is easy to carry and removes foreign substances like chewing gum when used and prevents whitening and tartar deposition. It provides aesthetic effects such as bad breath control and the treatment and prevention of gum disease.

Description

Jelly tablet toothpaste composition and its manufacturing method {Toothpsate composites type gel tablet and that of manufacturing method}

The present invention relates to an oral hygiene composition and a method for preparing the same, which is easy to deliver the refreshing feeling and oral hygiene active ingredient in the oral cavity, a jelly tablet type toothpaste composition of the tablet formulation, not a toothpaste of the conventional liquid or ointment paste formulation and its It relates to a manufacturing method.

In addition, the present invention is to form a powder formulation using a metal casting mold in the shape of the formulation and then coated with a syrup using xylitol in the following process or by coating the color with the gardenia blue pigment, easy to carry and chew gum when used As described above, the present invention relates to a jelly tablet type toothpaste composition and a method for preparing and treating aesthetics such as whitening, preventing tartar deposition, preventing bad breath, and preventing and treating gum disease.

Toothpaste is a drug compound used on a toothbrush for the purpose of cleaning and polishing teeth. It consists of powder, cream, liquid, and the like. It is made to help prevent or treat disinfection, tartar disintegration, odor reduction and tooth decay or alveolar pylori. As a component, a base is mentioned first. Calcium carbonate, calcium phosphate, calcium sulfate, magnesium carbonate, magnesium chloride, etc. are used for this. These are helpful for the mechanical cleaning of the teeth. If the size, hardness, and shape of the particles are not appropriate, they may damage the surface of the teeth. Therefore, the size of the particles should be about 1 to 20 μm and uniform. It is required to be sensitive, not hard, about 3 degrees of moss hard.

In addition to this base, detergents, perfumes, colorants, disinfectant disinfectants, tartar dissolving agents, neutralizing agents and the like are mixed little by little. In addition to the cream type, a binder, a stabilizer, and the like are added.

In other words, paste toothpaste is widely used as a toothpaste used for cleaning mouth and teeth, but if a certain time elapses after using the tube for a long time or leaving the lid of the tube, the front part of the tube solidifies and cannot be used easily. Often there is no. In addition, the toothpaste remaining in the tube during the use process can not be used completely, because the tube to which the toothpaste is injected disposable every time, was a waste, causing environmental pollution.

In order to solve such a problem, a toothpaste can be used relatively, and a liquid toothpaste capable of reusing a container has been proposed. However, such a liquid toothpaste is not actually used due to the problem that the liquid toothpaste composition flows easily during use and is very inconvenient and wasteful.

In addition, conventionally sold tablets toothpaste is a dry type of tablets to form a tablet at a constant pressure by tableting the powder formulation and water or gelling agent as a binder in the powder formulation is produced in a granular form after low pressure punching It takes a form to make.

In general, the manufacturing form is often made into a tablet form, and the powder binder is not produced and sold by LG H & H, but most of them use the latter.

In the case of powder tableting, the product is easily crushed because it is a method of tableting the powder directly, and also broken by transportation and shaking after packing, and a more serious disadvantage is that the powder dries and gets stuck in the mouth when it is chewed. There are disadvantages to feel,

In the case of granule-type perforated food, the granules are made of water or gelling agent and then manufactured by low pressure perforation, so that a slight pressure can easily change the dosage form, and there is a disadvantage of feeling a lot of foreign body with sticky feeling when chewing. have.

Therefore, the present applicant intends to propose a tablet-type toothpaste manufacturing method that compensates for the shortcomings produced through the granules and low-pressure punching.

[Related Technical Documents]

1.Jelly toothpaste and process for preparing the same (Patent Registration No. 10-1272225)

2. Method for making natural toothpaste (Patent Registration No. 10-1692232)

3, tablet toothpaste (Patent toothpaste No. 10-1272226)

The present invention has been made to solve the above problems, the purpose of which is to form a tablet formulation by punching the powder formulation in the shape of the formulation to form a tablet, HPMC (Hydroxypropyl methylcellulose: hydroxypropyl methyl) It is formed by coating with cellulose mixture, and is easy to carry. It is a jelly tablet type toothpaste composition which can remove and treat foreign substances like chewing gum when used and prevent and treat esthetics such as whitening, tartar deposition, and bad breath control, and prevent gum disease. To provide.

In addition, the present invention is to form a formulation using a metal casting mold in order to mold into a product having a tablet-like shape and coated with a syrup using xylitol in the following process or by coating the formulation using a gardenia blue pigment jelly tablet type The present invention provides a jelly tablet-type toothpaste composition and a method for preparing the same, which provides convenience for carrying or using the toothpaste after chewing toothpaste once or twice.

However, the objects of the present invention are not limited to the above-mentioned objects, and other objects not mentioned will be clearly understood by those skilled in the art from the following description.

Jelly tablet toothpaste composition according to the characteristics of the present invention for achieving the above object is 12.13% by weight of sorbitol, 10% by weight of silicon dioxide, 0.05% by weight of pyridoxine hydrochloride, 0.22% by weight of sodium fluoride, 1% by weight of sodium pyrophosphate, Sodium sulphate 3% by weight, enzyme-treated stevia 1.20% by weight, ascorbic acid 0.50% by weight, apple mint flavor powder 1% by weight, DL campa 1.50% by weight, MP (methylparaben) 0.10% by weight, peppermint oil 2% by weight, gum arabic 4% by weight, 57% by weight of furan and 1.30% by weight of gardenia blue pigment were mixed to form a formulation using a metal casting mold, coated with a formulation formed using 5% by weight of xylitol, and then dried. Features,

In addition, the jelly tablet type toothpaste manufacturing method according to an embodiment of the present invention is sorbitol, silicon dioxide, pyridoxine hydrochloride, sodium fluoride, sodium pyrophosphate, sodium lauryl sulfate, enzyme treatment stevia, ascorbic acid, apple mint flavor powder, DL camphor, A first step of mixing MP (methylparaben), peppermint oil, gum arabic, pullulan, and gardenia blue pigment into a mixer and mixing the same; A second process of forming a tablet formulation by perforating a metal casting mold to mold the mixed toothpaste powder formulation into a tablet-shaped form; And a third process of coating and drying the formulation formed through the second process with xylitol syrup; Characterized in that comprises a.

In addition, the method for preparing a jelly tablet toothpaste according to an embodiment of the present invention is a tablet toothpaste composition 12.13% by weight of sorbitol, 10% by weight of silicon dioxide, 0.05% by weight of pyridoxine hydrochloride, 0.22% by weight of sodium fluoride, 1% by weight of sodium pyrophosphate , Sodium lauryl sulfate 3% by weight, enzyme treatment stevia 1.20% by weight, ascorbic acid 0.50% by weight, apple mint flavor powder 1% by weight, campa 1.50% by weight, MP (methyl paraben) 0.10% by weight, peppermint oil 2% by weight, Arabia 4% by weight of gum, 57% by weight of furan, 1.30% by weight of gardenia blue pigment and 5% by weight of xylitol.

In addition, the method for preparing a jelly tablet toothpaste according to an embodiment of the present invention does not mix the gardenia blue pigment with the mixer in the powder preparation mixing process, but tablets through the tableting process and mixes the gardenia blue pigment with the coated formulation to the formulation. It is characterized by being configured to form.

Jelly tablet type toothpaste composition and a method for manufacturing the same according to the present invention is formed by coating the powder formulation in the form of a formulation by molding using a HPMC mixture used in tablets by molding in a casting mold and is easy to carry and use It removes foreign body like chewing gum and provides the effect of treating and preventing aesthetic and gum disease, such as whitening, prevention of tartar deposition and suppressing bad breath.

In addition, the jelly tablet toothpaste composition according to an embodiment of the present invention and a method for manufacturing the same in order to make a formulation using a metal casting mold to be molded into a product having a tablet shape and coated with a syrup using xylitol in the following process Using the Gardenia Blue Pigment, you can chew the jelly tablet type toothpaste once or twice by brushing the color of the preparation.You can brush your teeth by brushing or brushing without chewing. do.

1 is a flow chart showing a schematic process of a jelly tablet toothpaste manufacturing method according to the present invention.

Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings, and the following examples are provided only for better understanding of the present invention, and the contents of the present invention are limited by the embodiments. It is not.

The present invention is sorbitol, silicon dioxide, pyridoxine hydrochloride, sodium fluoride, sodium pyrophosphate, sodium lauryl sulfate, enzyme treatment stevia, ascorbic acid, apple mint flavor powder, xylitol, camphor, MP (methyl paraben), peppermint oil, gum arabic, It is easy to carry by molding the powder preparation of furan and gardenia blue pigment, and it is easy to carry, and it is a jelly tablet type that can treat and prevent aesthetic and gum disease such as whitening, prevention of tartar deposition, suppression of bad breath, etc. Toothpaste composition and a method for producing the same.

Hereinafter, sorbitol, silicon dioxide, pyridoxine hydrochloride, sodium fluoride, sodium pyrophosphate, sodium lauryl sulfate, enzyme treatment stevia, ascorbic acid, apple mint flavor powder, xylitol, camphor, MP (methylparaben), Looking at the active ingredients and features of peppermint oil, gum arabic, pullulan and gardenia blue pigment, first, sorbitol is a hexavalent alcohol obtained by reducing hexose, such as glucose, to give a sugar-like sweetness. Combustible and hygroscopic, white crystals, sweet and soluble in water and alcohol. It is found in juices such as apples, peaches, and rowan. Cosmetic lotions, creams, toothpastes, food additives, vitamin C (synthetic ingredients), sweeteners for diabetics, diuretics, etc. Melting point is 93 ~ 97.5 ℃. The formula is CH ₂ OH. (CHOH) ₄ CH ₂ OH. Sorbitol is a food additive and has various characteristics such as wetting control effect, protein denaturation, low calorie, low taste, hard tooth decay, insulin bean dependence, and is widely used in confectionery, food, aquatic products, toothpaste, cosmetics, and pharmaceutical industry. It is a low-moisture moisturizer with excellent heat resistance and freshness, and is widely used in foods such as toothpaste and sugar-free gum because it is not fermented by caries. In addition, it is excellent in protein denaturation and wetting control effect, it is also used as a cosmetic raw material and has excellent features to maintain the flavor of food and drink for a long time.

Silicon dioxide, called silicon dioxide (SiO ₂ ), is found naturally in water, plants, animals, and soils, and is primarily found in plants and cereals, with 59% of the earth's crust being silica and 95% of the known rock on earth. The above contains silicon dioxide. As a food additive, silicon dioxide is used as an antistatic agent.

The sodium fluoride is also called soda fluoride, a water-soluble sodium salt. When water containing water-soluble fluoride is used as a drink, it becomes a half-floor and bones become brittle. However, as currently tried in some countries, the addition of an appropriate amount of sodium fluoride to tap water has the effect of preventing tooth decay, strengthening hemorrhoids and enhancing acid resistance, and inhibiting the enzyme action of bacteria that ferment and produce acid. .

Pyridoxine hydrochloride is a white crystalline powder that is soluble in water but insoluble in alcohol and other organic solvents, and in yeast, grains, potatoes, cabbage, bananas, beans, meat, fish, eggs, and milk. It contains the component.

The sodium pyrophosphate is a colorless to white crystal or white crystalline powder, and the anhydride is a white powder, granular or lump pyrophosphate quality improving agent, and includes crystalline (10 hydrate) and anhydride, each of which is sodium pyrophosphate. (Crystal) and sodium pyrophosphate (anhydrous). The chemical formula is Na ₄ P ₂ O ₇ nH ₂ O. Soluble in water, insoluble in alcohol PH of aqueous solution (1 → 100) is 9.9-10.7.

Fe + +, Cu + +, Ca + + and other metal ions and strong soluble complex salts to make a strong blocking effect on metal ions. It is weatherable and changes to Na ₂ HPO ₄ when boiled in the presence of inorganic acids. Sodium pyrophosphate has a low degree of condensation, which is strong against thermal hydrolysis, and a high pH has specificity such as condensation phosphate.

It is used as an elasticity enhancer of fish meat products. The addition of sodium pyrophosphate, glucose and sorbic acid to fish sausage prevents the softening of products by bacteria. In dairy products, it is used as a melting agent and emulsifier of cheese. Casein in cheese is combined with calcium. Therefore, the addition of condensed phosphoric acid causes calcium to fall, increasing the viscosity of casein.

In general, when used in combination with phosphate, metaphosphate, etc., the cheese becomes soft and rich in reliance. It prevents discoloration of the liver, enhances color tone and gloss, increases consistency, and improves the effective state. It is effective in preventing oxidation and increasing viscosity of soft drinks, fruits and ice creams, and soft drinks have the effect of preventing precipitation during preservation.

In addition, it is effective in the promotion of ice cream overrun and emulsion dispersion of fat, and the addition of pyrophosphate increases the casein viscosity of ice cream.

The sodium lauryl sulfate (SLS) is a chemical used as a surfactant and a detergent, and is a component commonly found in automobile cleaners, garage floor cleaners, and engine grease (oil) cleaners. It is more widely used as a major component of cosmetics, toothpaste, hair conditioners and more than 90% of shampoos and foams.

The xylitol is found in Finland as a new sweetener of natural materials that do not form the acid that causes tooth decay, and is made from gum, such as birch or oak, as a raw material, It suppresses the enamel melting by the acid produced when the sugar is broken down. This sweetener is used to promote insulin secretion and to supply energy to diabetics as a substitute for glucose for medical purposes because it does not affect the blood sugar by entering the cell without intervening insulin action.

The extraction process is to first split the birch into water and heat it, the polysaccharide xylan is decomposed into xylose. The xylose can be converted to xylitol by increasing the purity through several processes and reducing it. Xylitol has a structure of five-saccharide sugar, so caries is eaten and discharged by the decayed bacteria such as mutans and sorbin bacteria. The surface of the tooth erodes, but the caries easily breaks down the hexasaccharides but not the xylitol, the pentose sugar. As a result, no acid (caused), which causes tooth decay, and eventually decayed bacteria that do not consume nutrients fall off the surface of the tooth.

In addition, xylitol has a refreshing effect that keeps the mouth cool, and is suitable for preventing tooth decay, such as promoting saliva secretion.

The Enzymatically Modified Stevia Glucosyl Stevia is a white-pale yellow powder, flake or liquid with no odor or a slight peculiar odor, refreshing sweetness, soluble in water and soluble in 50% alcohol.

The sweetness of enzymatically treated stevia is more similar to sugar than stevioside in stevia extract, and its sweetness is about 100 to 200 times that of sugar and stable to acid and inferiority. When used in combination with sugars such as sugar has an effect of increasing the sweetness.

Enzyme Treatment Stevia was obtained by purifying α-glucosyl stevioside and α-glucosylbaudioside A produced by applying α-Glucosyltransferase (α-glucosyltransferase) to stevia extract. It is glucosyl stevioside and should not be used for white sugar, brown sugar, glucose, syrup, honey, etc. When storing, avoid high temperature and high humidity and keep it sealed.

The ascorbic acid is also called vitamin C as one of the water-soluble vitamins. Chemical formula C ₆ H ₈ O ₆ was found to be effective for scurvy, and is currently synthesized from sorbose via ketogulonic acid. In nature, it contains a lot of green tea, lemon, spinach, cabbage, etc., especially in the adrenal cortex in the animal body.

Apple mint (apple mint) is a plant that is effective in preventing and treating colds, is resistant to cold and fertility, and grows well in a half-shade state, which is a kind of herb native to Europe. It is 30 ~ 60cm in height and smells like a mixture of apples and peppermint. It is reproduced by folding or abandonment. It has a mild scent like apple and peppermint. The leaves are round and soft in egg shape and have white hair. It smells like an apple and is used for various dishes and preservation of fragrance. It is effective for colds, cholera, gastrointestinal disorders, headaches, pain, sweating and hysteria, and is available as tea, sweets, beverages, cosmetics, soaps, bath products and potpourri. Drinking tea is effective in recovering from indigestion or fatigue and is used as a flavoring for meat, fish and egg dishes.

Making herbal tea with leaves is effective in recovering from indigestion or fatigue. In Europe, it is a spice that must be used in meat, and is also used in fish and egg. It is also medicinal, it is good for sterilization, dry tonic, soothing and analgesic effect.

DL-camphor is a cool cooling stimulating effect like menthol and is a transparent water-soluble granular type powder that dissolves in ethanol better than water and gives cooling stimulation effect so that it can be used with menthol in water paste and pars. It is strong and has good spreading characteristics. On the other hand, the menthol (menthol) is a mint crystal that adds a cool refreshing feeling to natural products, which is a rod-shaped crystal crystals that can be applied to oil phase, water phase, and used in shampoo, toothpaste, paste, water paste, foot spray, body products, etc. It is used for summer hair and body care by adding a toothpaste to the mouth and giving a sense of clogged nose to rhinitis. Menthol is mixed with oil / moisture. see. The alternative raw material for menthol is peppermint oil.

The MP (methyl paraben) is a mixture of methanol and para-hydroxy, and is a preservative component used as a fragrance or antiseptic preservative, and is also used as a preservative for pharmaceuticals and cosmetics such as topical antibiotics, injections, corticosteroids, and food and beverage.

Methylparaben is a substance found in breast cancer tumors by promoting the secretion of estrogens and causes contact dermatitis, allergies, blemishes, and wrinkles.In addition, preservatives are added to cosmetics to help them last longer. Specialized ingredient.

The peppermint (Peppermint) is about 90 cm in height, the stem is straight or up from the roots, the roots spread out to the ground spreading the leaves with fine hairs are pointed to face each other, there is a leaf stem, serrated edge There are 5-8 pairs of leaf veins. The flower is purple and blooms in aquatic inflorescence in the axilla from June to July. The calyx of the bell shape is divided into 5 pieces, and the calyx of 4 parts is longer than the calyx, and the dried stems in the fresh leaves or the airy shade are also used as cooking ingredients.

Menthol, the main ingredient of peppermint essential oil, cools the skin and mucous membranes, and is effective for antibacterial and pain relief. It is used as a raw material for edible, medicinal and fragrances.

Peppermint contains a large number of menthols, which can alleviate toothache through pain relief, which can alleviate pain.It also has the effect of relieving respiratory diseases such as sore throat and tonsillitis. , Peppermint peculiar fragrance has the advantage of removing bad breath.

The gum gum (Gum arabic) is a kind of natural gum made by hardening the sac of acacia, which has been extracted from Acacia nilotica, but recently extracted from Acacia senegal and Vachellia (Acacia) seyal. gum, which is a polymer mixture of glycoprotein and polysaccharide, is used to obtain arabinose and ribose first extracted and separated from gum arabic, and is mainly used as a stabilizer in the food industry. Used in viscosity control, printing, cosmetics and textile industries.

Pullulan is called an edible film. An edible film is a general term used for edible films. It is a film used in food packaging. It is a film made mainly of edible materials such as carbohydrates and proteins. to be. The edible film has a water-soluble and non-water-soluble type, and the water-soluble is a microbial Pullulan film, and there are plant polysaccharides of oblide, carrageenan, alginic acid, agar film, and cellulose derivative film which is a semi-short polysaccharide. The water-insoluble film has a vegetable protein film of plant type and a collagen film of animal type.

On the other hand, the use of the edible film is frozen food, instant noodles, frozen noodles soup packaging material, frozen food processing aids, laminated food binders, cotton and fish paste separation material, processed food packaging materials such as ham and sausage, pharmaceuticals It is used as a packaging material.

Therefore, in the present invention, it is used as a raw material of the jelly tablet-type toothpaste through mixing and mixing in a edible jelly paste state by mixing with gum arabic edible material.

Figure 1 shows a flow chart illustrating a schematic process of a method for producing a jelly tablet toothpaste composition according to the present invention.

Jelly tablet type toothpaste composition manufacturing method according to the present invention comprises a powder formulation mixing step (S100), purification step (S200), coating step (S300), drying step (S400) and packaging step (S500).

Hereinafter, with reference to the accompanying Figure 1 will be described in detail for each step of the method for preparing a jelly tablet toothpaste composition of the present invention.

(1) Powder formulation mixing process (S100)

Wetting agents, abrasives, thickeners, preservatives, sweeteners, antioxidants, sorbitols, silicon dioxide, pyridoxine, sodium fluoride, sodium pyrophosphate, sodium lauryl sulfate, enzymatically treated stevia, ascorb Powder formulations of acid, applemint flavor powder, DL-Camphor, MP (methylparaben), peppermint oil, gum arabic, pullulan and gardenia blue pigment are added to a mixer and mixed.

More specifically, the jelly tablet toothpaste composition is 12.13% by weight of sorbitol, 10% by weight of silicon dioxide, 0.05% by weight of pyridoxine hydrochloride, 0.22% by weight of sodium fluoride, 1% by weight of sodium pyrophosphate, 3% by weight of sodium lauryl sulfate, enzyme treatment stevia 1.20 wt%, 0.50 wt% ascorbic acid, 1 wt% applemint powder, 1.50 wt% DL camphor, 0.10 wt% MP (methylparaben), 2 wt% peppermint oil, 4 wt% gum arabic, 57 wt% flulan And 1.30% by weight of gardenia blue pigment in a suitable amount and put into the mixer.

Wetting agents are used as sorbitol (surfactant) to increase the wettability by having a moderate humidity.

The abrasive removes dirt on the tooth surface and brightens the teeth. Silicon dioxide can be used. On the other hand, the silicon dioxide serves as a thickener and viscosity regulator, the antioxidant ascorbic acid (ascorbic acid) is used as an additive to block the oxidation reaction, the peppermint oil is to remove bad breath and prevent toothache, Sodium fluoride, a medicinal component, is used to prevent cavities, prevent pustules, whiten teeth, prevent tartar deposition, and prevent bad breath.

The abrasive is to remove the plaque, tartar, etc. attached to the teeth to give the original gloss to the tooth surface, the enamel quality of the tooth is 6-7, so the abrasive does not damage the quality of the tooth The hardness of 3 or less is used, and the particle diameter of an abrasive | polishing agent is a small thing of 1-20 micrometers. The content of the abrasives is limited in the above range so as not to damage the enamel of the tooth.

The sodium fluoride may be applied as a plaque remover to remove the plaque by inhibiting bacteria in the oral cavity and to exert the effect of preventing oral disease and removing bad breath in the oral cavity.

Sodium lauryl sulfate (SLS), a foaming agent, can be used to make foaming easier to remove dirt.

On the other hand, the sodium lauryl sulfate (SLS) is a blowing agent to reduce the interfacial tension by the action of a surfactant to increase the cleaning effect of brushing, and has the effect of helping to disperse and penetrate the compounded formulation, as a preservative Methyl paraben (MP) can be used.

(2) Refining Process (S200)

The powder formulation for preparing the mixed tablet toothpaste is perforated in a metal casting mold to form a tablet having a tablet shape to form a tablet formulation.

(3) Coating process (S300)

The formulation formed through the purification process is coated with a syrup of 5% by weight of xylitol.

The xylitol is a natural sweetener that feels sweet and effective in preventing tooth decay. It has a five-sugar structure, and the lactic acid that eats and releases glucose, fructose, and the like, which are cavities, such as mutans or sorbin, are present in food. It is the phenomenon that the surface of teeth is corroded. Tooth decay bacteria easily decompose hexose but not xylitol. As a result, no acid, the cause of tooth decay, and cavities that do not consume nutrients fall off the tooth surface.

On the other hand, as another embodiment of the present invention can be formed by mixing the gardenia blue pigment in the coating formulation by the tableting process without mixing the gardenia blue pigment into the mixer in the powder formulation mixing process to form a color sense. .

(4) Drying process (S400)

The formulation formed through the coating process proceeds to a drying process.

(5) Packaging Process (S600)

The dried jelly formulations are packaged for use in tablet form of toothpaste.

For jelly tablet toothpaste composition according to the present invention, sorbitol, silicon dioxide, pyridoxine, sodium fluoride, sodium pyrophosphate, sodium lauryl sulfate, enzyme treatment stevia, ascorbic acid, applemint flavor powder, xylitol, DL-campa, MP ( The antimicrobial activity test and the effect acceptability diagram of the biological substance were prepared by adjusting the contents of the powder preparations of methylparaben), peppermint oil, gum arabic, pullulan, and gardenia blue pigment, and the tablet toothpaste produced under the same conditions of tableting, coating, and drying. The comparison was observed through.

Hereinafter, specific examples will be described.

(Example 1)

As shown in Table 1, 12.13% by weight of sorbitol, 10% by weight of silicon dioxide, 0.05% by weight of pyridoxine hydrochloride, 0.22% by weight of sodium fluoride, 1% by weight of sodium pyrophosphate, 3% by weight of sodium lauryl sulfate, 1.20% by weight of enzyme treatment stevia %, Ascorbic acid 0.50 wt%, applemint flavor powder 1 wt%, campa 1.50 wt%, MP (methylparaben) 0.10 wt%, peppermint oil 2 wt%, gum arabic 4 wt%, pullulan 57 wt% and gardenia blue Bovine 1.30% by weight of the formulation was mixed, a formulation was made using a metal casting mold, coated with 5% by weight of xylitol and dried to prepare a tablet tablet toothpaste composition.

(Example 2)

As shown in Table 1, 13.13% by weight of sorbitol, 10% by weight of silicon dioxide, 0.05% by weight of pyridoxine hydrochloride, 0.22% by weight of sodium fluoride, 1% by weight of sodium pyrophosphate, 3% by weight of sodium lauryl sulfate, 1.20% by weight of enzyme treatment stevia %, Ascorbic acid 0.50 wt%, applemint flavor powder 1 wt%, campa 1.50 wt%, MP (methylparaben) 0.10 wt%, peppermint oil 2 wt%, gum arabic 4 wt%, pullulan 57 wt% and gardenia blue A tablet jelly tablet-type toothpaste composition was prepared by mixing a small amount of the formulation of 1.30% by weight, making a formulation using a metal casting mold, coating it with 4% by weight of xylitol, and drying it.

(Example 3)

As shown in Table 1, 13.13% by weight of sorbitol, 10.50% by weight of silicon dioxide, 0.05% by weight of pyridoxine hydrochloride, 0.22% by weight of sodium fluoride, 1% by weight of sodium pyrophosphate, 3% by weight of sodium lauryl sulfate, 1.20% by weight of enzyme treatment stevia %, Ascorbic acid 0.50 wt%, applemint flavor powder 1 wt%, campa 1.50 wt%, MP (methylparaben) 0.10 wt%, peppermint oil 2 wt%, gum arabic 4 wt%, pullulan 57 wt% and gardenia blue A tablet jelly tablet-type toothpaste composition was prepared by mixing a small amount of the formulation of 1.30% by weight, making a formulation using a metal casting mold, coating it with 3.50% by weight of xylitol, and drying it.

 Composition comparison table Example 1 Example Example 3 Sorbitol 12.13 13.13 13.13 Silicon dioxide 10 10.00 10.50 Pyridoxine hydrochloride 0.05 0.05 0.05 Sodium fluoride 0.22 0.22 0.22 Sodium pyrophosphate 1.00 1.00 1.00 Sodium Lauryl Sulfate 3.00 3.00 3.00 Xylitol 5.00 4.00 3.50 Enzyme Treatment Stevia 1.20 1.20 1.20 Ascorbic acid 0.50 0.50 0.50 Apple Mint Flavor Powder 1.00 1.00 1.00 Kampa 1.50 1.50 1.50 Methylparaben 0.10 0.10 0.10 Peppermint Oil 2.00 2.00 2.00 Arabian sword 4.00 4.00 4.00 Pluran 57.00 57.00 57.00 Gardenia Blue 1.30 1.30 1.30

Experimental Example 1

Experimental Example 1 below is to test the in vitro antimicrobial activity against oral harmful bacteria of each tablet type and uncoated tablet type of Table 1, 4 g of the sample prepared in Example was put into a 300 ml Erlenmeyer flask and sterilized Then, 1 ml of diluted culture medium and 99 ml of phosphate buffer (pH 7.0) were added, followed by shaking culture (120 rpm) for 24 hours at 37 ° C. Then, the test strain was taken out of the freeze-preserved state, inoculated in Nutrient broth, and then incubated for 48 hours in an incubator at 37 ° C. After incubation for 12-20 hours in the incubator again after 1% (v / v) inoculation, the reduction rate of each strain was measured in comparison with the initial bacterial count.

Test strains are microorganisms that cause tooth decay in the oral cavity. ; ATCC 25586).

After incubation again for 12-20 hours, the initial bacterial count was compared with the number of strains (cells / ml) and the reduction rate (%) after 2 days.

The results described above are shown in Table 2 below, when the antimicrobial activity (sterilization power) is summarized as Table 2 below, as a percentage (%) of the bactericidal rate obtained by the concentration of residual bacteria relative to the initial inoculation concentration.

Antimicrobial Results Test strain Experimental Example 1 Experimental Example 2 Experimental Example 3 Strap Tucker's Mutans Experimental group 470 ± 60/89 490 ± 50/91 510 ± 60/93 Control 9280 ± 100 (95% increase) 9540 ± 100 (97% increase) 9730 ± 100 (97% increase) Peugeot bacterium nucleus Experimental group 870 ± 75/80 890 ± 90/85 910 ± 65/91 Control 8925 ± 110 (93% increase) 9215 ± 110 (95% increase) 9359 ± 110 (96% increase)

As can be seen from Experimental Example 1, as shown in Table 2, in the control group without xylitol, the number of strains increased with time. However, in case of the experimental group, the number of strains was greatly reduced over time, indicating that the antimicrobial effect of the jelly tablet toothpaste composition of the present invention was excellent. From the above results, the present invention is expected to effectively remove various harmful caries in the oral cavity to prevent periodontal disease.

Experimental Example 2

Experimental Example 2 below is to use the adult male and female for each of the compositions of Examples 1 to 3 prepared according to the composition ratio shown in Table 1 above, the bad breath removal, plaque removal, the feeling of use on a 5-point scale method According to the sensory test, the average value is shown in Table 3 below.

Sensory test result Inspection items Example 1 Example 2 Example 3 Bad breath 4.7 4.5 4.5 Gingivitis suppression 4.5 4.5 4.3 Plaque removal 4.5 4.3 4.4 Feeling 4.4 4.4 4.2

Very good 5, Good 4, Usually 3, Bad 2, Very bad 1

As can be seen from the above Experimental Example 2, as shown in Table 3, as the content of xylitol increases plaque removal and bad breath removal, but the feeling is gradually improved, in particular, the xylitol-containing gingivitis inhibitory effect It was confirmed that the degree of preference corresponding to.

Therefore, the jelly tablet toothpaste composition in the present invention is 12.13% by weight of sorbitol, 10% by weight of silicon dioxide, 0.05% by weight of pyridoxine hydrochloride, 0.22% by weight of sodium fluoride, 1% by weight of sodium pyrophosphate, 5% by weight of xylitol, sodium lauryl sulfate 3 Weight%, enzyme treated stevia 1.20 weight%, ascorbic acid 0.50 weight%, apple mint flavor powder 1 weight%, DL-campa 1.50 weight%, MP (methylparaben) 0.10 weight%, peppermint oil 2 weight%, gum arabic 4 weight It can be seen that the tablet composition composed of%, 57% by weight of furan, and 1.30% by weight of gardenia blue pigment can satisfy all of bad breath removal, gingivitis removal, plaque removal, and usability.

In the above, the specific embodiments of the present invention have been described in detail, but specific terms used herein are only used for the purpose of describing the present invention, and the meanings of the terms and limitations of the present invention described in the claims are limited. It was not used to. Therefore, those skilled in the art can make various modifications and various other equivalent embodiments therefrom.

Claims (4)

Sorbitol 12.13 wt%, Silicon dioxide 10 wt%, Pyridoxine hydrochloride 0.05 wt%, Sodium fluoride 0.22 wt%, Sodium pyrophosphate 1 wt%, Sodium lauryl sulfate 3 wt%, Enzyme treated stevia 1.20 wt%, Ascorbic acid 0.50 wt%, Formulation of 1% by weight of applemint flavor powder, 1.50% by weight of DL-campa, 0.10% by weight of MP (methylparaben), 2% by weight of peppermint oil, 4% by weight of gum arabic, 57% by weight of pullulan and 1.30% by weight of gardenia blue pigment Jelly tablet-type toothpaste composition, characterized in that the mixture is formed by using a metal casting mold to form a formulation and formed by coating and drying the formulation formed using 5% by weight of xylitol.
Sorbitol, Silicon Dioxide, Pyridoxine Hydrochloride, Sodium Fluoride, Sodium Pyrophosphate, Sodium Lauryl Sulfate, Enzyme Treatment Stevia, Ascorbic Acid, Apple Mint Flavor Powder, DL-Kampa, MP (Methylparaben), Peppermint Oil, Arabian Gum, Flulan and A first step of mixing the powder preparation of gardenia blue pigment by mixing into a mixer;
A second process of forming a tablet formulation by perforating a metal casting mold to mold the mixed toothpaste powder formulation into a tablet-shaped form; And
A third process of coating and drying the formulation formed through the second process with xylitol syrup; Jelly tablet toothpaste manufacturing method characterized in that it comprises a.
The method of claim 2,
Tablet toothpaste composition is 12.13 wt% sorbitol, 10 wt% silicon dioxide, 0.05 wt% pyridoxine hydrochloride, 0.22 wt% sodium fluoride, 1 wt% sodium pyrophosphate, 3 wt% sodium lauryl sulfate, 1.20 wt% enzyme treatment stevia, ascorbate 0.50 wt% acid, 1 wt% applemint flavor powder, 1.50 wt% DL-campa, 0.10 wt% MP (methylparaben), 2 wt% peppermint oil, 4 wt% Arabian gum, 57 wt% pullulan, gardenia blue Jelly tablet toothpaste manufacturing method, characterized in that consisting of 1.30% by weight and 5% by weight of xylitol.
The method of claim 2,
Jelly tablets, characterized in that in the powder formulation mixing process of the first step is to mix the gardenia blue pigment with a tableting process without mixing the gardenia blue pigment in the mixer and to form a color by mixing the gardenia blue pigment in the formulation Type toothpaste manufacturing method.

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