KR20190088806A - Toothpsate composites type gel tablet and that of manufacturing method - Google Patents

Abstract

The present invention relates to a jelly tablet-type toothpaste composition and a method for preparing the same. In particular, the method comprises: mixing a preparation containing 12.13 wt% of sorbitol, 10 wt% of silicon dioxide, 0.05 wt% of pyridoxine hydrochloride, 0.22 wt% of sodium fluoride, 1 wt% of sodium pyrophosphate, 3 wt% of sodium lauryl sulfate, 1.20 wt% of enzyme-treated stevia, 0.50 wt% of ascorbic acid, 1 wt% of applemint scent powder, 1.50 wt% of camphor, 0.10 wt% of methylparabene (MP), 2 wt% of peppermint oil, 57 wt% of flurane, and 1.30 wt% of gardenia blue color, to produce a formulation by using a metal casting frame; coating the produced formulation with 5 wt% xylitol; and drying the same. Accordingly, the powder preparation is tableted in a casting frame having a formulation shape so as to be formed into a tablet form and is coated with an HPMC mixture which is used for tablet-type medications, such that the tableted tablet is easy to carry and can be chewed like a chewing gum without undesirable feels to provide aesthetic benefits, such as whitening the teeth, preventing plague buildup, and preventing bad breath, and also the effects of treating and preventing periodontal diseases.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a toothpaste composition,

The present invention relates to an oral care composition which is easy to deliver a refreshing sensation in the oral cavity and an oral hygiene agent, and a method for preparing the same. More particularly, the present invention relates to a tablet form dentifrice composition of a tablet form, And a manufacturing method thereof.

The present invention also relates to a method for preparing a pharmaceutical composition, which comprises preparing a powder formulation by using a metal casting mold in the form of a powder, coating it with syrup using xylitol as a next step, The present invention relates to a dentifrice composition of a jelly-refining type which can be used for aesthetic and gum diseases, such as whitening, prevention of dental calculus, prevention of bad breath, and the like.

Toothpaste is a complex material that is used as a toothbrush to clean and polish teeth. It is made of powder, cream or liquid. Disinfecting action, dental dissolution action, smell decaying action, and tooth decay and dental caries. As a constituent, a base may be mentioned first. These include calcium carbonate, calcium phosphate, calcium sulfate, magnesium carbonate, magnesium chloride and the like. These are useful for mechanical cleaning of teeth. If the size, hardness, and shape of the particles are not appropriate, there is a risk of damaging the surface of the teeth. Therefore, the size of the particles should be approximately 1 to 20 μm, Not to be sensitive, hardness of about 3 degrees of firmness of the moss is required as a condition of the mechanism.

In addition to these bases, detergents, fragrances, dyes, disinfectants, tartar solubilizers, neutralizers, etc. are mixed little by little. In addition to the cream type, a bonding agent, a stabilizer and the like are added.

In other words, although paste toothpaste is widely used as a toothpaste used for cleaning the oral cavity and teeth, if the lid of the tube is left open for a long time or a certain time has elapsed, the front portion of the tube is solidified, There are many cases that do not exist. In addition, the toothpaste remaining in the tube can not be completely used in the course of use, and the tube into which the toothpaste is injected must be discarded each time as disposable, which is wasteful and causes environmental pollution.

In order to solve such a problem, a liquid toothpaste which can relatively use toothpaste and can reuse the container has been proposed. However, such liquid toothpaste is not practically used due to the problem that the liquid dentifrice composition flows easily during its use, which is very inconvenient to use and wasteful.

In addition, existing tablet type toothpaste is a dry type, which is prepared by tableting a powder preparation at a constant pressure, or when preparing a granule by adding water or a gelling agent as a binder to a powder preparation, Taking form.

The general manufacturing form is often made into tablets, while powdered drug binders do not produce or sell LG Household & Health Care, but the latter is the latter.

In the case of powdered tablets, the product is easily crumbled due to the method of directly powdering the powder. Also, the product is broken even after being packed and transported and shaking, and the more fatal drawback is that the powder is dried during chewing, There is a disadvantage to feel,

In the case of a granule-type tablet, the granule is made by adding water or a gelling agent, and then it is made into a low-pressure pore. Therefore, when the pressure is slightly applied, the formulation can easily change. Also, have.

Accordingly, the applicant intends to propose a method of manufacturing a tablet-type toothpaste that compensates for the disadvantages of being manufactured through granular punch and low pressure punch.

[Related Technical Literature]

1. Jelly toothpaste and process for preparing the same (Patent Registration No. 10-1272225)

2. Method for making natural toothpaste (Patent Registration No. 10-1692232)

3, Tablet toothpaste (Patent Registration No. 10-1272226)

Disclosure of the Invention The present invention has been conceived in order to solve the above-mentioned problems, and its object is to provide a powdered pharmaceutical preparation, Cellulosic) composition, which is easy to carry and removes a foreign body feeling like chewing gum during use, prevents osteoporosis, prevents bad breath, and can treat and prevent gum disease, and a method of manufacturing the same .

The present invention also relates to a method for forming a tablet having a shape of a tablet, comprising the steps of: preparing a formulation using a metal casting mold; coating the syrup with xylitol as a next step; applying a coloring agent to the preparation using a blue- The present invention provides a dentifrice composition for jelly tablets which provides convenience in carrying or use so that toothpaste can be chewed once or twice after chewing, and a method for producing the same.

However, the objects of the present invention are not limited to the above-mentioned objects, and other objects not mentioned can be clearly understood by those skilled in the art from the following description.

In order to accomplish the above object, the present invention provides a dentifrice composition for a jelly tablet, comprising 12.13 wt% of sorbitol, 10 wt% of silicon dioxide, 0.05 wt% of pyridoxine hydrochloride, 0.22 wt% of sodium fluoride, 1 wt% of sodium pyrophosphate 3% by weight of sodium persulfate, 1.20% by weight of enzyme-treated Stevia, 0.50% by weight of ascorbic acid, 1% by weight of apple mint flavor powder, 1.50% by weight of Kampa, 0.10% by weight of MP (methyl paraben) By weight, and 1.30% by weight of jet mill blue color, mixing the formulation, forming a formulation using a metal casting mold, coating the formulation using 5% by weight of xylitol, and drying.

In addition, the method for producing a jelly-refined toothpaste according to an embodiment of the present invention may include a method of preparing a toothpaste of jelly-refining type, wherein the toothpaste is selected from the group consisting of sorbitol, silicon dioxide, pyridoxine hydrochloride, sodium fluoride, sodium pyrophosphate, sodium laurylsulfate, enzyme-treated stevia, ascorbic acid, (Methylparaben), peppermint oil, fluoran, and a powder of a flower of a flower of a gardenia; A second step of punching the metal mold casting mold to form a tablet-like formulation so as to form a mixed toothpaste powder preparation into a shape having a tablet shape; And a third step of coating and drying the formulation formed through the second step with xylitol syrup; And a control unit.

In the method of manufacturing a dentifrice of the present invention, the purified dentifrice composition may contain 12.13 wt% of sorbitol, 10 wt% of silicon dioxide, 0.05 wt% of pyridoxine hydrochloride, 0.22 wt% of sodium fluoride, 1 wt% of sodium pyrophosphate, 3% by weight of sodium lauryl sulfate, 1.20% by weight of enzyme-treated Stevia, 0.50% by weight of ascorbic acid, 1% by weight of apple mint flavor powder, 1.50% by weight of Kampa, 0.10% by weight of MP (methylparaben) Is composed of 57% by weight of egg white, 1.30% by weight of ginger blue and 5% by weight of xylitol.

In addition, in the method of manufacturing a jelly-purified dentifrice according to an embodiment of the present invention, in the mixing step of powdery preparation, Is formed.

The jellied tablet type dentifrice composition and the method for manufacturing the same according to the present invention are formed by coating powder formulations in a form of a casting mold and shaping into a tablet form, coating with HPMC mixture used in tablet form medicine, It provides a cosmetic and gum disease treatment and prevention effect such as whitening of gum, prevention of whitening of dental plaque, inhibition of bad breath,

In addition, the jellied tablet type dentifrice composition and the method for manufacturing the same according to the embodiment of the present invention can be manufactured by forming a tablet using a metal casting mold and then coating with syrup using xylitol as a next step It uses a blue toothpick to apply color to the preparation, and after chewing the jelly-refining toothpaste once or twice, it can be brushed by brushing or brushing without chewing, so it is convenient to use so that the proper amount of water can be replaced instead of toothbrush. do.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a flow chart showing a schematic process of a method of manufacturing a jelly-cleansing toothpaste according to the present invention; FIG.

Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings. The following embodiments are provided to facilitate understanding of the present invention. It is not.

The present invention relates to a process for the preparation of a medicament for the preparation of a medicament for the treatment and / or prophylaxis and / or treatment of a disease or condition selected from the group consisting of sorbitol, silicon dioxide, pyridoxine hydrochloride, sodium fluoride, sodium pyrophosphate, sodium lauryl sulphate, enzyme treated stevia, ascorbic acid, apple mint fragrance, xylitol, The present invention relates to a dentifrice composition for jelly tablets which can be used for aesthetic purposes such as whitening, prevention of dental calculus, inhibition of bad breath, and treatment and prevention of periodontal disease, And a manufacturing method thereof.

Hereinafter, the present invention will be described in more detail with reference to the following examples, which are used in the formulations of the present invention, such as sorbitol, silicon dioxide, pyridoxine hydrochloride, sodium fluoride, sodium pyrophosphate, sodium laurylsulfate, enzyme treated stevia, ascorbic acid, apple mint flavor powder, xylitol, First, sorbitol is a type of hexa-alcohols obtained by reducing hexose, such as glucose, and gives a sweet taste similar to sugar. It is a white crystal with flammability and hygroscopicity. It has a sweet taste and is soluble in water or alcohol. It is contained in the juice of apple, peach, Cosmetics lotion, cream, toothpaste, food additive, vitamin (C) synthesis raw material, diabetic sweetener, diuretic, etc. The melting point is 93 ~ 97.5 ℃. The formula is CH ₂ OH (CHOH) ₄ CH ₂ OH. Sorbitol is a food additive that has been used extensively in confectionery, food, aquatic products, toothpaste and cosmetics industries, and pharmaceuticals industries, as it has various characteristics such as wetting control effect, prevention of protein denaturation, low calorie, It has excellent heat resistance and refreshing sensation. It is not used for fermentation by tooth decubitus bacteria. Therefore, it is widely used for foods such as toothpaste and sugar-free gum. In addition, it is excellent in prevention of protein denaturation and adjustment of wetness, and is widely used as a raw material for cosmetics, and is excellent in refinement, so that the flavor of food and beverage is sustained for a long time.

The above silicon dioxide is called silicon dioxide (SiO ₂ ) and is naturally found in water, plants, animals and soils. It is mainly found in plants and cereals. The earth crust is 59% silica and 95% And silicon dioxide. Silicon dioxide as a food additive is used as an anticaking agent.

The sodium fluoride is also referred to as sodium fluoride, which is a water-soluble sodium salt. When water containing water-soluble fluoride is used as a drinking water, it becomes irregular and becomes brittle. However, as is currently being attempted in some countries, the addition of an appropriate amount of sodium fluoride to tap water has the effect of preventing tooth decay, strengthening the hemorrhoids, enhancing acid resistance, inhibiting the enzymatic action of fermentation and acid producing bacteria .

Syrup Pyridoxine hydrochloride is a white crystalline powder that is well soluble in water but is insoluble in alcohol and other organic solvents. It has a very high solubility in yeast, grain, potatoes, cabbages, bananas, beans, meat, fish, eggs, And its components are contained.

Wherein the sodium pyrophosphate is a colorless to white crystal or a white crystalline powder and the anhydride is a white powder, granular or lumpy pyrophosphate quality improver, which is a crystalline product (10 hydrate) and an anhydrous product, each of which is a sodium pyrophosphate (Crystals) and sodium pyrophosphate (anhydrous). The formula is Na ₄ P ₂ O ₇ .nH ₂ O. It is soluble in water and does not dissolve in alcohol. The pH of the aqueous solution (1 → 100) is 9.9 to 10.7.

Fe +++, Cu ++, Ca +++, and other metal ions and the ability to make strong complexes, strong blocking effect on metal ions. It is weatherable and when boiled in the presence of mineral acid, it changes to Na ₂ HPO ₄ . Sodium pyrophosphate has a low degree of condensation and is highly resistant to thermal hydrolysis. When pH is high, it has the same specificity as condensed phosphoric acid. It has dispersing and peptizing action and is widely used in foods for preventing oxidation of fat.

It is used as an elasticity enhancer of fish meat products, and adding sodium pyrophosphate, glucose and sorbic acid to fish meat sausage prevents softening of products by bacteria. In dairy products, cheese is used as a melting agent and as an emulsifier. Since casein in cheese is bound to calcium, the addition of condensed phosphoric acid causes the calcium to fall and the viscosity of casein to increase.

Generally, when mixed with citric phosphate, metaphosphate, etc., the cheeses become soft and the qualities become rich. Prevention of discoloration of the liver, enhancement of color and gloss, increase of viscosity and improvement of u-state. It is effective to prevent oxidation and increase viscosity in soft drinks, fruits and ice drinks. Soft drinks have the effect of preventing sedimentation during preservation.

In addition, it is effective in promoting ice cream overrun and emulsifying and dispersing fat, and when pyrophosphate is added, casein viscosity of ice cream is increased.

Sodium Lauryl Sulfate (SLS) is a chemical used as a surfactant and detergent. It is a component commonly found in automobile cleaners, garage floor cleaners, and engine grease (oil) cleaners. Cosmetics, toothpaste, hair conditioners and more than 90% of shampoo and foam detergents.

The above xylitol is a new sweetener of natural material which does not form an acid which causes tooth decay. It is found in Finland. It is made from gum and other ingredients taken from trees such as birch and oak tree, It inhibits the melting of the enamel quality by the acid generated when the sugar is decomposed. This sweetener promotes the secretion of insulin because it does not interfere with insulin action and does not affect the blood sugar in the cells. Therefore, it is also used for energy supply to substitute glucose for medical use for diabetics.

In the extraction process, first, the birch is finely divided and heated in water, and the polysaccharide, xylan, is decomposed and transformed into xylose. The xylitol is converted to xylitol by reducing the purity of the xylose through various processes and then reducing it. Since xylitol has a pentose structure, the tooth decay is caused by lactic acid which eats and discharges glucose and fructose contained in food, The surface of this tooth is corroded, but the carotid bacterium easily decomposes the hexose, but the pentose xylitol can not decompose. As a result, the cause of tooth decay, acid (acid) does not occur, and consequently, the tooth decayed from the tooth surface.

Furthermore, xylitol is also used as an additive for tooth decay foods, which is suitable for prevention of cavities, such as promoting saliva secretion, even with a refreshing effect that refreshes the mouth.

Enzymatically Modified Stevia Glucosyl Stevia is a white to pale yellow powder, flake or liquid which is odorless or has a peculiar odor, has a sweet taste, is well soluble in water and is soluble in 50% alcohol.

The sweetness of the enzyme-treated stevia is similar to that of stevioside among stevia extracts, and its sweetness is about 100 to 200 times that of sugar, and it is stable to acid and heat. When used together with saccharides such as sugar, it has an effect of increasing the degree of sweetness.

Enzymatic treatment Stevia was obtained by purifying α-glucosyl stevioside and α-glucosylbaidoside A produced by acting α-glucosyltransferase (α-glucosyltransferase) on Stevia extract. The major component of sweetness was α- It is glucosyl stevioside, and it should not be used in white sugar, brown sugar, glucose, syrup, honey and the like. Avoid high temperature and high humidity during storage and keep sealed.

The ascorbic acid is also referred to as vitamin C as one of the water-soluble vitamins. It was found to be a substance which is specific for scurvy as the formula C ₆ H ₈ O _{6. It} is now being industrially synthesized from sorbose via ketogluconic acid. It is contained in green tea, lemon, spinach, cabbage, etc. in nature, and is contained in adrenal cortex especially in animal.

The apple mint is an effective plant for preventing and treating colds. It has a cold tolerance and a high fertility, and grows mainly in a semi-slack state. It is 30 ~ 60cm high and has a scent like apples and mint. It grows by breaking or giving up. It has a mild scent like apples and peppermint. Leaves are egg-shaped, round and soft and have white hairs. It has a scent like an apple and it is used for preserving various dishes and fragrance. It is effective for cold, cholera, gastrointestinal disease, headache, analgesic, sweating, hysteria, tea, sweets, beverage, cosmetics, soap, bath products, potpourri. Drinking tea is effective in preventing digestion and fatigue, and is used as a flavor of meat, fish, and egg dishes.

It is effective for digestion failure and fatigue recovery by making herbal tea with leaves. It is a spice that must be included in meat dishes in Europe. It is also used for fish dishes and egg dishes. It is also used medicinally, it is good for disinfection, dryness, soothing, and analgesic action, and also has the effect of eliminating bad breath, so it is mixed with toothpaste.

DL-camphor has cool cooling effect like menthol and transparent water-soluble granular type powder. It is more soluble in ethanol than water and gives cool stimulating effect, so it can be used with menthol in waterpast, pars, etc. It is cheaper than menthol, There is a strong and spreading characteristic. Meanwhile, menthol is a mint crystal that gives a cooling sensation to a natural product. It is a rod-shaped crystal crystal and can be applied to oil phase and water phase. It can be used in shampoo, toothpaste, pars, waterpush, When added to toothpaste, it catches the smell of the mouth, and rhinitis gives the impression of having a blocked nose. It is used for summer hair and body care. Menthol is mixed with oil / water and if oil is dissolved in water, see. Peppermint oil is used as an alternative raw material for menthol.

MP (methylparaben) is a mixture of methanol and para-hydroxy. It is a preservative ingredient used as a perfume or a sterilizing preservative. It is also used as a medicine for antibiotics, injections, corticosteroids and other medicines, cosmetics, and food and beverage preservatives.

Methylparaben promotes estrogen secretion and is found in breast cancer tumors. It causes contact dermatitis, allergies, spots and wrinkles. Cosmetics contain preservatives to help maintain the shelf life, Is a special ingredient.

The peppermint (Peppermint) is about 90㎝ in height, and its stem comes out of its roots and stands up or goes up. It spreads on the ground with its roots spreading. The leaf with fine hairs is pointed with a pointed face, leaf stalk, There are 5 to 8 pairs of veins. The flowers are purple and bloom in June ~ July in the axilla. The bell-shaped calyx is divided into five pieces, the four-parted corolla is longer than the calyx, and the vigorous stem is used as a cooking material in the shade of green leaves and windy.

Menthol, the main ingredient in peppermint essential oil, is used as an ingredient in edible, medicinal and perfume products, which is effective in relieving skin and mucous membranes, and being effective in antibacterial and pain relief.

Peppermint contains a lot of menthol, so it can alleviate toothache through analgesic effect that alleviates the pain. It is effective in alleviating respiratory-related diseases such as sore throat and tonsillitis. When it is included in toothpaste, , A unique flavor of peppermint has the advantage of removing bad breath.

The gum arabic has been extracted from Acacia nilotica as a kind of natural gum made by hardening acacia sap. Recently, most of gum arabic is extracted from Acacia senegal and Vachellia (Acacia) seyal. gum. It is a mixture of arabic black sugar and polysaccharide. It is used for obtaining arabinose and ribose, which is first extracted and separated from Arabian gum. It is mainly used as a stabilizer in the food industry. Viscosity control, printing, cosmetics, and textile industries.

Pullulan is called an edible film. Edible film is a film used in food packaging as a collective term for edible films. It is a film that mainly uses edible materials and ingredients such as carbohydrates and proteins. to be. The edible film has water-soluble and water-insoluble types, water-soluble silver microbial Pullulan film, and vegetable polysaccharides oblate, carrageenan, alginic acid, agar film and cellulosic derivative film as a half-polysaccharide. The water-insoluble film is a vegetable protein film which is a plant system, and an animal type collagen film.

On the other hand, edible films are used for frozen food, instant soup, soup packings for frozen foods, processing aid materials for frozen foods, binders for laminated foods, separating materials for cotton and fish paste, processed food packaging materials such as ham and sausage, It is used as packing material.

Therefore, in the present invention, it is mixed with the gum arabic gum as an edible jelly paste, and is used as a raw material of the jelly-refining type toothpaste through casting.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a flow chart showing a schematic process of a method of manufacturing a dentifrice composition of the present invention.

The method for preparing a dentifrice composition of the present invention comprises a powder preparation mixing step (S100), a refining step (S200), a coating step (S300), a drying step (S400) and a packing step (S500).

Hereinafter, a method for manufacturing a dentifrice composition of the present invention will be described in detail with reference to FIG. 1.

(1) Powder preparation mixing process (S100)

For the production of jelly-refillable toothpaste, it is recommended to use a humectant, an abrasive, a thickening agent, a preservative, a sweetener, an antioxidant, a sorbitol corresponding to a medicinal ingredient, silicon dioxide, pyridoxine hydrochloride, sodium fluoride, sodium pyrophosphate, Powder preparations such as acid, apple mint flavor powder, DL-Camphor, MP (methyl paraben), peppermint oil, fluoran, and gardenia blue are put into a mixer and mixed.

More specifically, the jellied tablet type dentifrice composition comprises 12.13% by weight of sorbitol, 10% by weight of silicon dioxide, 0.05% by weight of pyridoxine hydrochloride, 0.22% by weight of sodium fluoride, 1% by weight of sodium pyrophosphate, 3% by weight of sodium lauryl sulfate, 1.20% by weight of ascorbic acid, 0.50% by weight of ascorbic acid, 1% by weight of apple mint flavor powder, 1.50% by weight of DL-campa, 0.10% by weight of MP (methylparaben), 2% by weight of peppermint oil, 57% The weight% is cooled in an appropriate amount and placed in a mixer.

The wetting agent is sorbitol, which is used as a surfactant, in order to have a proper humidity and increase the wettability.

The abrasive removes dirt from the surface of the teeth and shines the teeth, and silicon dioxide can be used. On the other hand, the silicon dioxide acts as a thickening agent and a viscosity controlling agent, and ascorbic acid, which is an antioxidant, is used as an additive to block the oxidation reaction. The peppermint oil is to remove bad breath and prevent toothache, Sodium fluoride, which is a medicinal ingredient, uses fluorine compounds to give effects such as prevention of tooth decay, prevention of agitation, tooth whitening, prevention of plaque deposition, and prevention of bad breath.

The abrasive is used to remove the jig attached to the teeth and to give the tooth a luster on its own. Since the hardness of the enamel of the tooth is 6 to 7, the abrasive does not damage the quality of teeth Hardness of 3 or less is used, and the particle diameter of the abrasive is as small as 1 to 20 占 퐉. The content of the abrasives is limited to the above range so as not to damage the enamel quality of the teeth.

Sodium fluoride can be used as a plaque remover to remove plaque by inhibiting bacteria in the oral cavity and to prevent oral diseases and to remove bad breath.

Sodium Lauryl Sulfate (SLS), the foaming agent, can be used to easily remove dirty foam.

Sodium Lauryl Sulfate (SLS) is a foaming agent that reduces the interfacial tension by the action of a surfactant, enhances the cleaning effect of the brushing, assists in dispersing and penetrating the compounded medicinal composition, (MP) can be used.

(2) Purification process (S200)

In order to form the powder preparation for preparing the mixed tablet type dentifrice into a tablet shape, the tablets are formed into a metal casting mold.

(3) Coating process (S300)

The formulation formed through the purification process is coated with syrup of 5% by weight of xylitol.

The xylitol is a natural sweetener, which makes sweetness feel and has an effect on the prevention of cavities. The lactic acid which eats and discharges the glucose, fructose, etc. contained in the food is a mutant microorganism such as mutans bacteria or sorbitol It is a phenomenon that the surface of the tooth is corroded. The tooth decay easily breaks down the hexose, but the pentose xylitol can not break down. As a result, the acid causing the tooth decay does not occur, and the tooth decaying bacteria that can not take the nutrient eventually come off the tooth surface.

Meanwhile, as another embodiment of the present invention, in the powder preparation mixing step, the coloring can be formed by mixing the blue-violet powder with the formulation in the formulated coating by tableting without mixing the blue-violet powder into the mixer .

(4) Drying step (S400)

The formulation formed through the coating process is subjected to a drying process.

(5) Packing process (S600)

The dried jelly formulations are packaged to suit the use of tablets of tablets.

The dentifrice composition according to the present invention may contain at least one selected from the group consisting of sorbitol, silicon dioxide, pyridoxine hydrochloride, sodium fluoride, sodium pyrophosphate, sodium laurylsulfate, enzyme-treated stevia, ascorbic acid, apple mint flavor powder, xylitol, DL- Methylparaben), peppermint oil, fluoran, and blue powder, and comparing the antibacterial activity of the purified toothpaste produced under the same conditions of purification, coating and drying, Respectively.

Hereinafter, a specific embodiment will be described.

(Example 1)

As shown in the following Table 1, 12.13 wt% of sorbitol, 10 wt% of silicon dioxide, 0.05 wt% of pyridoxine hydrochloride, 0.22 wt% of sodium fluoride, 1 wt% of sodium pyrophosphate, 3 wt% of sodium lauryl sulfate, , 0.5% by weight of ascorbic acid, 1% by weight of apple mint flavor powder, 1.50% by weight of iscamine, 0.10% by weight of MP (methylparaben), 2% by weight of peppermint oil, 57% The formulation was mixed and made into a formulation using a metal casting mold, coated with 5% by weight of xylitol, and dried to prepare a tablet tablet type dentifrice composition.

(Example 2)

As shown in the following Table 1, there were prepared 13.13 wt% of sorbitol, 10 wt% of silicon dioxide, 0.05 wt% of pyridoxine hydrochloride, 0.22 wt% of sodium fluoride, 1 wt% of sodium pyrophosphate, 3 wt% of sodium lauryl sulfate, , 0.5% by weight of ascorbic acid, 1% by weight of apple mint flavor powder, 1.50% by weight of camphor, 0.10% by weight of MP (methylparaben), 2% by weight of peppermint oil, 57% by weight of pullulan and 1.30% And a metal mold casting mold was used to prepare a formulation. The composition was coated with 4 wt% of xylitol and dried to prepare a tablet jelly tablet type dentifrice composition.

(Example 3)

As shown in the following Table 1, there were prepared 13.13 wt% of sorbitol, 10.50 wt% of silicon dioxide, 0.05 wt% of pyridoxine hydrochloride, 0.22 wt% of sodium fluoride, 1 wt% of sodium pyrophosphate, 3 wt% of sodium lauryl sulfate, , 0.5% by weight of ascorbic acid, 1% by weight of apple mint flavor powder, 1.50% by weight of camphor, 0.10% by weight of MP (methylparaben), 2% by weight of peppermint oil, 57% by weight of pullulan and 1.30% , A formulation was made using a metal casting mold, coated with 3.50% by weight of xylitol, and dried to prepare a tablet jelly tablet type dentifrice composition.

 Composition comparison table Example 1 Example Example 3 Sorbitol 12.13 13.13 13.13 Silicon dioxide 10 10.00 10.50 Pyridoxine hydrochloride 0.05 0.05 0.05 Sodium fluoride 0.22 0.22 0.22 Sodium pyrophosphate 1.00 1.00 1.00 Sodium lauryl sulfate 3.00 3.00 3.00 Xylitol 5.00 4.00 3.50 Enzyme treatment Stevia 1.20 1.20 1.20 Ascorbic acid 0.50 0.50 0.50 Apple Mint Flavored Powder 1.00 1.00 1.00 Campa 1.50 1.50 1.50 Methyl paraben 0.10 0.10 0.10 Peppermint oil 2.00 2.00 2.00 Arabian sword 4.00 4.00 4.00 Pullulan 57.00 57.00 57.00 Gardenia blue 1.30 1.30 1.30

[Experimental Example 1]

The following Experimental Example 1 was conducted to examine the in vitro antimicrobial activity against oral harmful bacteria of each of the tablets of Table 1 and the uncoated tablets. 4 g of the sample prepared in the above Example was placed in a 300 ml Erlenmeyer flask, 1 ml of the diluted culture medium and 99 ml of phosphate buffer (pH 7.0) were added thereto, followed by shaking culture (120 rpm) at 37 ° C for 24 hours. Then, the test strain was taken out from the freeze storage state, inoculated into Nutrient broth, and cultured for 48 hours in an incubator at 37 ° C. Each test strain thus pre-cultured was suspended in 100 ml of Nutrient broth After 1% (v / v) inoculation, the cells were cultured again for 12-20 hours in the incubator.

The test strain is a strain that induces cavities in the oral cavity, and Streptococcus mutans (NCTC 10449), which is distributed from the Korean Microorganism Conservation Center, and Fusobacterium nucleatum (NCTC 10449), which causes periodontal disease and bad breath, ; ATCC 25586) was used.

After the culture for 12-20 hours, the number of cells (ml / ml) and the decrease rate (%) were measured after 2 days with the initial number of bacteria.

The results are shown in Table 2 below as summarized in Table 2 below as the antibacterial activity (sterilizing power) as a percent reduction in percent (%) determined by the concentration of the residual bacteria relative to the initial inoculum concentration.

Results of antibacterial activity Test strain Experimental Example 1 Experimental Example 2 Experimental Example 3 Strap Tacacus Mutans Experimental group 470 ± 60/89 490 ± 50/91 510 ± 60/93 Control group 9280 ± 100 (95% increase) 9540 ± 100 (97% increase) 9730 ± 100 (97% increase) Peugeot Bacterium Nuclearum Experimental group 870 ± 75/80 890 ± 90/85 910 ± 65/91 Control group 8925 ± 110 (93% increase) 9215 ± 110 (95% increase) 9359 ± 110 (96% increase)

As can be seen from Experimental Example 1, as shown in Table 2, the number of the strains increased with time in the control group without xylitol. However, in the case of the experimental group, the number of strains was greatly decreased over time, indicating that the dentifrice composition of the present invention has excellent antibacterial effect. From the above results, it is expected that the present invention will effectively remove various harmful tooth decays in the oral cavity and prevent periodontal disease.

[Experimental Example 2]

The following Experimental Example 2 was carried out for each of 10 male and female adults of the compositions of Examples 1 to 3 prepared according to the composition ratios shown in Table 1 above, and the odor elimination, plaque elimination, The sensory evaluation was carried out and the average value thereof is shown in Table 3 below.

Sensory test result Inspection items Example 1 Example 2 Example 3 Removing bad breath 4.7 4.5 4.5 Gingival suppression 4.5 4.5 4.3 Remove the plaque 4.5 4.3 4.4 Feeling 4.4 4.4 4.2

Very good 5, good 4, usually 3, bad 2, very bad 1

As can be seen from the above Experimental Example 2, as shown in Table 3, as the xylitol content was increased, plaque removal and bad breath removal were improved, but the feeling of use was gradually improved. In particular, Were similar to each other.

Accordingly, in the present invention, the dentifrice composition of the present invention comprises 12.13 wt% of sorbitol, 10 wt% of silicon dioxide, 0.05 wt% of pyridoxine hydrochloride, 0.22 wt% of sodium fluoride, 1 wt% of sodium pyrophosphate, 5 wt% of xylitol, 1% by weight of enzyme treated stevia, 0.50% by weight of ascorbic acid, 1% by weight of apple mint flavor powder, 1.50% by weight of DL-campa, 0.10% by weight of MP (methyl paraben), 2% by weight of peppermint oil, % And 1.30% by weight of gardenia blue can satisfy all of the following: bad breath removal, gingivitis removal, plaque removal and feeling.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments. It is not used for. Therefore, those skilled in the art will appreciate that various modifications and equivalent arrangements may be made therein without departing from the scope of the present invention.

Claims (4)

10 weight% of sorbitol, 10 weight% of silicon dioxide, 0.05 weight% of pyridoxine hydrochloride, 0.22 weight% of sodium fluoride, 1 weight% of sodium pyrophosphate, 3 weight% of sodium lauryl sulfate, 1.20 weight% of enzyme treated stevia, 0.50 weight% of ascorbic acid, A mixture of 1% by weight of apple mint flavor powder, 1.50% by weight of DL-campa, 0.10% by weight of MP (methyl paraben), 2% by weight of peppermint oil, 57% by weight of pullulan and 1.30% Wherein the composition is formed by forming a formulation using a mold and coating a formulation formed using 5% by weight of xylitol and drying the composition.
Powder preparations of sorbitol, silicon dioxide, pyridoxine hydrochloride, sodium fluoride, sodium pyrophosphate, sodium lauryl sulfate, enzyme-treated stevia, ascorbic acid, apple mint flavor powder, camphor, MP (methyl paraben), peppermint oil, Into a mixer to mix them;
A second step of punching the metal mold casting mold to form a tablet-like formulation so as to form a mixed toothpaste powder preparation into a shape having a tablet shape; And
A third step of coating and drying the formulation formed through the second step with xylitol syrup; The method of claim 1,
3. The method of claim 2,
The purified dentifrice composition comprises 12.13 wt% sorbitol, 10 wt% silicon dioxide, 0.05 wt% pyridoxine hydrochloride, 0.22 wt% sodium fluoride, 1 wt% sodium pyrophosphate, 3 wt% sodium lauryl sulfate, 1.20 wt% enzyme treated stevia, 0.5% by weight of acid, 1% by weight of apple mint flavor powder, 1.50% by weight of DL-campa, 0.10% by weight of MP (methylparaben), 2% by weight of peppermint oil, 57% by weight of pullulan, 1.30% % ≪ / RTI > by weight based on the weight of the toothpaste.
3. The method of claim 2,
The method of claim 1 or 2, wherein in the step of mixing the powdery preparation in the first step, the blue-colored gum is blended through a purification process without mixing in a mixer, and the gum- Method of manufacturing toothpaste.

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