CN107362112A - One kind shield gum healing toothpaste - Google Patents
One kind shield gum healing toothpaste Download PDFInfo
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- CN107362112A CN107362112A CN201710635736.XA CN201710635736A CN107362112A CN 107362112 A CN107362112 A CN 107362112A CN 201710635736 A CN201710635736 A CN 201710635736A CN 107362112 A CN107362112 A CN 107362112A
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- toothpaste
- cordyceps militaris
- shield gum
- healing
- extract
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention discloses one kind shield gum healing toothpaste, Cordyceps militaris elite, allantoin, tranexamic acid, the alcohol of O cymenes 5, potassium nitrate and Rhizoma Zingiberis zerumbet extract are included.Shield gum healing toothpaste of the present invention has outside significant effects of antiinflammation and bacteriostasis, it is also equipped with preventing bleeding gums, shield gum effect of canker sore, comprehensive prevention and can solve a variety of oral problems, the crowd for being suitable for the oral problems such as the bleeding of gum redness, gingivitis, hemodia shouting pain uses.
Description
Technical field
The present invention relates to a kind of toothpaste, and in particular to one kind shield gum healing toothpaste.
Background technology
Gingivitis, periodontitis, sensitivity of tooth and canker sore etc. are all current most commonly seen mouth diseases, oral health
Importance also recognized therewith by crowd.Gingivitis shows as bleeding gums, red and swollen, distending pain, continues development and invades sclerous tissues,
Periodontitis, including the inflammation of gingiva tissue and general disease are produced in the performance of gum.Bleeding gums majority is because on facing
The soft dirt of bacterial plaque (bacterium) do not remove in time, bacterial plaque calcification is formed dental calculus, corresponding portion by the calcium ion in saliva at leisure
The gum of position is stimulated by dental calculus for a long time, telangiectasis, permeability enhancing, CBF increase, causes gum to be changed into fresh
Red or kermesinus, gingival papilla swelling, stippling disappear, edge is thickening, and gum is no longer close to facing, cause gum it is soft it is fragile,
Gingival sulcus is deepened.When brushing teeth or feeding, due to mechanical irritation, the gum under this inflammatory conditions is just easy to bleeding.
Know that the generation of multiple oral disease is relevant with the bacterium in oral cavity, in order to prevent or treat mouth disease, should be done from inhibiting bacteria and diminishing inflammation
Rise, integrally improve oral cavity flora environment from root cause problems.
The content of the invention
A kind of shield gum healing toothpaste is provided it is an object of the invention to overcome the shortcomings of the prior art part.
To achieve the above object, the technical scheme taken of the present invention is：One kind shield gum healing toothpaste, includes Cordyceps militaris essence
China, allantoin, tranexamic acid, O- cymene -5- alcohol, potassium nitrate and Rhizoma Zingiberis zerumbet extract；The Cordyceps militaris elite is Cordyceps militaris
The mixture of extract and fruiting bodies of cordyceps militaris.
Cordyceps militaris, be the edible mushroom of food and medicament dual-purpose, Cordyceps militaris extract of the present invention, can by commercially available,
It can be the refined extract of fruiting bodies of cordyceps militaris gained after water extract-alcohol precipitation.Fruiting bodies of cordyceps militaris is to pass through Cordyceps militaris spawn
It is inoculated on solid medium, after the regular hour cultivates, the stroma of crocus is differentiated to form from hyphostoma development
(fructification), and this new fresh sporophore is gathered into laggard sector-style again and dry grinded obtained by the processing of powder；Fructification powder passes through water extracting alcohol
After refined processing after heavy, cordycepin, adenosine, cordycepic acid, polysaccharide, SOD enzymes and other functional ingredient are efficiently concentrated, especially
It is cordycepin functional component.
Fruiting bodies of cordyceps militaris in the present invention, it is made up of materials such as moisture, ash content, protein, fat, wherein containing more
Kind volatile compound, it is in the majority with aromatic aldehydes material, there is certain antibacterial and anti-inflammatory effect, but aromatic volatile composition is equal
More than one hour can not be retained under 50 DEG C of extraction temperature.Therefore, the active ingredient in fruiting bodies of cordyceps militaris definitely can not
Remained in above-mentioned refined heating purification process, therefore the present invention is by the addition of fruiting bodies of cordyceps militaris, can allow pupa worm
The grass seed entity volatile ingredient of itself completely enters toothpaste system.
Cordycepin, is first nucleosides separated from fungi antibiotics, molecular structure 3 ,-desoxyadenossine,
There is broad-spectrum antiseptic, research is found, it can suppress the growth of the pathogens such as streptococcus, staphylococcus, and cordycepin
Also there is stronger antiviral activity, thus play in formulation of tooth-paste natural antibacterial, anti-inflammatory, it is antiviral the effect of.Due to worm
Careless element is the main antipathogenic composition in Cordyceps militaris extract, and the addition of Cordyceps militaris extract directly affects cordycepin in toothpaste
Content in formula.The present invention uses arrange in pairs or groups Cordyceps militaris extract of fruiting bodies of cordyceps militaris, can make in system containing cordycepin,
Outside the multiple efficacies compositions such as cordycepic acid, polysaccharide, SOD enzymes, the also volatile ingredient containing fruiting bodies of cordyceps militaris itself, so as to allow
The effect of shield gum shield tooth, is played to optimal.
Allantoin, it is present in the plants such as the Chinese yam of nature, beet, wistaria flower, has and repair epithelial tissue, promotes skin
Skin ulcer, the effect of wound healing.Allantoin is applied in toothpaste system, and sterilization, antiulcer are played in common oral care, is resisted
The effect such as oxidation, optional commercially available prod, such as Merck companiesAllantoin etc..
Tranexamic acid, alias are tranexamic acid, are applied in the traumatic bleeding symptom of various clinical, can suppress fibrinolytic
The effect of enzyme, there are preferably hemostasis and anti-inflammatory effects, commercially available prod, such as the limited public affairs of Nanjing Si Baike biochemistry industry can be selected
Tranexamic Acid of department etc..
O- cymene -5- alcohol, it is a kind of bactericide of wide spectrum, there is potent infiltration bactericidal action, to golden yellow grape
Also oral cavity pathogen all has good antibacterial effect for coccus, porphyromonas gingivalis, can penetrate into bacterial plaque inner sterilization,
Suitable for inflammatory patients such as gingivitis, periodontitis, optional commercially available prod, such as Nanjing Si Baike biochemistry Industrial Co., Ltd.
Isopropyl Methylphenol etc..
Potassium nitrate, desensitization activity in the monograph of the desensitizing dental product of food and medicine Surveillance Authority of the U.S. (FDA) into
Point, the release of potassium ion, the nerve endings of dentinal tubule can be prevented to be activated, can be with enough potassium concentrations
Avoid pressing Intradental nerve to be upset, the permeability of dentine is reduced, so as to slow down the situation of dentine hypersensitivity.
Rhizoma Zingiberis zerumbet, is distributed in China Hainan, Yunnan, Guangxi, India, the Malay Peninsula, Indonesia waited, to be perennial
Persistent root herbs.Rhizoma Zingiberis zerumbet can be used to anti-inflammatory and eliminate pain, and main active is sesquiterpenoids and flavonoids, is particularly
Zerumbone in ketone, zerumbone can play a part of to ease toothache.Rhizoma Zingiberis zerumbet extract of the present invention, commercially available production can be selected
Product, such as Zingiber Zerumbet Extract of Croda companies etc..
Cordyceps militaris elite, allantoin, tranexamic acid, O- cymene -5- alcohol, potassium nitrate and Rhizoma Zingiberis zerumbet extract are applied to
Shield gum healing toothpaste of the present invention, energy compound synergic, while playing hemostasis, shield gum, Shu Min effects, greatly strengthen toothpaste
It is formulated the antibacterial effect of overall anti-inflammatory.
Preferably, the shield gum healing toothpaste includes the preparing raw material of following weight percentage：Cordyceps militaris elite 0.1~
5%th, allantoin 0.1~2%, tranexamic acid 0.05~0.1%, O- cymene -5- alcohol 0.01~0.1%, potassium nitrate 3~10%
With Rhizoma Zingiberis zerumbet extract 0.1~1%.
Cordyceps militaris puies forward elite, and there is preferable inhibiting bacteria and diminishing inflammation to act on, and the increase of the content with Cordyceps militaris elite, suppression
Bacterium effect enhancing.Study and draw repeatedly through inventor, when the content of Cordyceps militaris elite is less than 0.1%, Cordyceps militaris elite is in toothpaste
Played in bacteriostasis it is not notable, but when Cordyceps militaris elite content be more than 5% when, with the addition of Cordyceps militaris elite
Increase, fungistatic effect increase is not notable, comprehensive production cost and fungistatic effect, when the content of Cordyceps militaris elite is 0.1~5%
When, there is preferable bactericidal action；When each component cooperates under the ratio, effects of antiinflammation and bacteriostasis significantly increases, can be effective
Ground mitigates gum redness bleeding problems.
Preferably, the shield gum healing toothpaste includes the preparing raw material of following weight percentage：Cordyceps militaris elite 0.5~
3%th, allantoin 0.2~0.8%, tranexamic acid 0.05~0.08%, O- cymene -5- alcohol 0.05~0.08%, potassium nitrate 3~
5% and Rhizoma Zingiberis zerumbet extract 0.1~0.5%.
Study and draw repeatedly through inventor, the overall mouthfeel of comprehensive anti-inflammatory fungistatic effect and toothpaste, when each group be divided into it is above-mentioned
Reach optimal during content, gum redness bleeding problems significantly improve.
Preferably, the weight ratio of the Cordyceps militaris extract and fruiting bodies of cordyceps militaris is：Cordyceps militaris extract：Cordyceps militaris
Entity=80~99.9：0.01~20.
When Cordyceps militaris extract and fruiting bodies of cordyceps militaris use above-mentioned weight ratio, both can give full play to respective effect,
System is set to contain cordycepin, cordycepic acid, polysaccharide, SOD enzymes and a variety of volatile compounds, so as to reach the work(of shield gum shield tooth
Effect.
It is highly preferred that the weight ratio of the Cordyceps militaris extract and fruiting bodies of cordyceps militaris is：Cordyceps militaris extract：Cordyceps militaris
Fructification=85~92：8~15.
When Cordyceps militaris extract and fruiting bodies of cordyceps militaris use above-mentioned weight ratio, the bactericidal effect that toothpaste reaches is optimal.
Preferably, the preparing raw material of the shield gum healing toothpaste also includes NMF, rubbing agent, thickener and foaming agent.
Preferably, in the preparing raw material of the shield gum healing toothpaste, the weight percentage of the NMF for 40~
60%, the weight percentage of the rubbing agent is 14~30%, and the weight percentage of the thickener is 0.5~3%, institute
The weight percentage for stating foaming agent is 1.8~3%.
Preferably, the foaming agent is at least one of amino acid surfactant and amphoteric surfactant and 12
The mixture of sodium alkyl sulfate.
It is highly preferred that the foaming agent is sodium lauroyl sarcosine, sodium lauroylmethyl taurate and cocamidopropyl propyl amide
At least one of glycine betaine and the mixture of lauryl sodium sulfate.
When foaming agent of the present invention only uses lauryl sodium sulfate, foam is few and thin, and mouthfeel of brushing teeth is slightly poor, ammonia of arranging in pairs or groups
When at least one of base acid surfaces activating agent, amphoteric surfactant, lather quickness can be accelerated, foam is fine and smooth abundant, solution
Certainly dry and astringent still sensory issues.The foaming agent is selected from commercially available prod, for example, Shanghai Austria can be selected in sodium lauroyl sarcosine
The OLI-4901 of Shanghai profit difficult to understand, Cocoamidopropyl betaine can be selected in the OLI-4208 of profit, lauroyl N-methyltaurine sodium
Galaxy Surfactants CAPB DC, the Lenotain C30 that Shanghai profit is contained can be selected, wherein CAPB DC are specially for suitable.
Preferably, the rubbing agent be precipitated silica, superfine silicon dioxide, calcium monohydrogen phosphate and calcium carbonate at least
It is a kind of.
It is highly preferred that the rubbing agent be at least one of precipitated silica, calcium monohydrogen phosphate and calcium carbonate with it is ultra-fine
The mixture of silica, wherein, in the preparing raw material of the shield gum healing toothpaste, the weight percentage of superfine silicon dioxide
For 2~6%.
Weight percentage of the superfine silicon dioxide in the preparing raw material of the toothpaste is 2~6%.When ultra-fine two
When silica dosage is less than 2%, lotion surface is more rough, and mouthfeel of brushing teeth can be poor, when superfine silicon dioxide dosage is more than 6%
When, be easily hardened under lotion high temperature water outlet, influences stability.The liquid absorption of superfine silicon dioxide is 30~44ml/20g, preferably
30~38ml/20g superfine silicon dioxide, commercially available prod, such as comprehensive silica of snow company etc. can be used.It is heavy
The liquid absorption of shallow lake type silica is 15~25ml/20g, preferably 18~22ml/20g Precipitated silicon dioxide, can be used
Commercially available prod, such as Zeodent115 of HUBER companies etc..The liquid absorption of calcium bicarbonate is 5.0~6.5ml/20g, apparent close
Spend and tend to maximum, while apparent density trend minimum value for 0.80~1.00g/mL, preferably liquid absorption, commercially available production can be used
Product, such as toothpaste grade calcium hydrophosphate of De Bang companies etc..The liquid absorption of calcium carbonate is 3.8~5.0ml/20g, preferably 3.8~
4.2ml/20g calcium carbonate, commercially available prod, such as calcite in powder of Man Tingfang companies etc. can be used.
Preferably, the thickener is at least one of sodium carboxymethylcellulose, carbomer and xanthans；The moisturizing
Agent is at least one of D-sorbite, glycerine, polyethylene glycol and propane diols.
Commercially available prod can be selected in sodium carboxymethylcellulose, such as the TH10 (toothpaste level) of ASHLAND companies, its substitution value are
0.75~1.02, preferably 0.95~1.02,2% solution viscosity are 600~3000mPas, preferably 1200~
2500mPas cellulose.Carbomer can be selected commercially available prod, such as Lubrizol companies
POLYMER (toothpaste level), pH value is adjusted in 7 or so (in 6.5-7.5 interval ranges), use with 25%NaOH solution
Brookfield RV6 rotors survey its viscosity, 0.6% neutralization solution viscosity under 20rpm：15000~40000mPas,
It is preferred that in 20000~30000mPas.Xanthans, also known as xanthan gum, optional commercially available prod, such as CPKelco companiesXanthan Gum (oral cavity level), its 1% xanthans is in 1%KCl solution, with Brookfield RV6
Rotor surveys its viscosity under 20rpm, and viscosity is 1200~1600mPas.
The shield gum healing toothpaste of the present invention, in addition to said components clearly require, in the model of lossless effect of the invention
In enclosing, other adjunct ingredients can be added or used to, auxiliary material can be sweetener, pH adjusting agent, spices, colouring agent and fluoride
Conventional content can be selected according to conventional criteria Deng, those skilled in the art.
Preferably, the shield gum healing toothpaste also includes the composition of following mass percent：Sweetener 0.1~2%, pH are adjusted
Save agent 0.1~3% and spices 0.1~2%.
Preferably, the sweetener is at least one of saccharin sodium, Sucralose and STEVIA REBAUDIANA；The spices is peppermint
At least one of brain, peppermint oil, spearmint oil, wintergreen, American mint, orange oil, lemon oil, fennel oil, eucalyptus oil；Institute
PH adjusting agent is stated as at least one in sodium hydroxide, ATSP, sodium tripolyphosphate, alkaline phosphate and sodium dihydrogen phosphate
Kind.
The preparation method of above-mentioned shield gum healing toothpaste, comprises the following steps：
(1), potassium nitrate and auxiliary material are pre-dissolved；
(2), rubbing agent, thickener are premixed；
(3), the material in NMF and step (1) is added in cream tank processed；
(4) vacuum system of cream tank processed, is opened, is vacuumized, by mixture, Cordyceps militaris elite, allantois obtained by step (2)
Element, tranexamic acid, O- cymene -5- alcohol and Rhizoma Zingiberis zerumbet extract add, and keep vacuum between -0.05Mpa~-0.085Mpa
It is stirred homogeneous；
(5) foaming agent, is added in cream tank processed, keeps vacuum to continue stirring between -0.05Mpa~-0.085Mpa equal
Matter；
(6), will cream tank processed to deaerate to vacuum be -0.092Mpa~-0.098Mpa, go out cream, produce the shield gum healing
Toothpaste.
The beneficial effects of the present invention are：The invention provides one kind shield gum healing toothpaste, shield gum healing of the present invention
Toothpaste has outside significant effects of antiinflammation and bacteriostasis, is also equipped with preventing bleeding gums, shield gum effect of canker sore, can be comprehensive
Prevent and solve a variety of oral problems, be suitable for the people of the oral problems such as the bleeding of gum redness, gingivitis, hemodia shouting pain
Group uses.
Brief description of the drawings
Fig. 1 is antibacterial test comparison figure of the embodiment 5 with 1~5 toothpaste of comparative example to staphylococcus aureus；
Fig. 2 is antibacterial test comparison figure of the embodiment 5 with 1~5 toothpaste of comparative example to streptococcus mutans；
Fig. 3 is antibacterial test comparison figure of the embodiment 5 with 1~5 toothpaste of comparative example to porphyromonas monococcus.
Embodiment
To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention
It is described further.
Embodiment 1
A kind of embodiment of shield gum healing toothpaste of the present invention, include the preparing raw material of following weight percentage：Pupa
Lungfit 0.1%, allantoin 0.1%, tranexamic acid 0.05%, O- cymene -5- alcohol 0.05%, potassium nitrate 3%, Rhizoma Zingiberis zerumbet
Extract 0.1%, NMF 40%, rubbing agent 14%, thickener 0.5%, foaming agent 1.8%, sweetener 0.1%, pH regulations
The deionized water of agent 0.1%, spices 0.1% and surplus；
Wherein, the Cordyceps militaris elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris, and the Cordyceps militaris carries
The weight of the thing and fruiting bodies of cordyceps militaris ratio is taken to be：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=99.9：0.01；The NMF
For D-sorbite；The thickener is sodium carboxymethylcellulose；The foaming agent is sodium lauroyl sarcosine and dodecyl sulphur
The mixture of sour sodium；The mixture of the rubbing agent precipitated silica and superfine silicon dioxide, superfine silicon dioxide is described
The weight percentage protected in the preparing raw material of gum healing toothpaste is 2%；The sweetener is saccharin sodium；The spices is peppermint
Brain；The pH adjusting agent is alkaline phosphate and sodium dihydrogen phosphate.
Embodiment 2
A kind of embodiment of shield gum healing toothpaste of the present invention, include the preparing raw material of following weight percentage：Pupa
Lungfit 5%, allantoin 2%, tranexamic acid 0.1%, O- cymene -5- alcohol 0.1%, potassium nitrate 10%, Rhizoma Zingiberis zerumbet extraction
Thing 1%, NMF 40%, rubbing agent 20%, thickener 3%, foaming agent 3%, sweetener 2%, pH adjusting agent 3%, spices 2%
With the deionized water of surplus；
Wherein, the Cordyceps militaris elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris, and the Cordyceps militaris carries
The weight of the thing and fruiting bodies of cordyceps militaris ratio is taken to be：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=80：20；The NMF is mountain
The mixture of pears sugar alcohol and glycerine；The thickener is the mixture of sodium carboxymethylcellulose and carbomer；The foaming agent is
The mixture of sodium lauroylmethyl taurate and lauryl sodium sulfate；The rubbing agent is calcium monohydrogen phosphate and superfine silicon dioxide
Mixture, superfine silicon dioxide it is described shield gum healing toothpaste preparing raw material in weight percentage be 6%；The sweet tea
Taste agent is Sucralose；The spices is spearmint oil；The pH adjusting agent is sodium hydroxide.
Embodiment 3
A kind of embodiment of shield gum healing toothpaste of the present invention, include the preparing raw material of following weight percentage：Pupa
Lungfit 0.5%, allantoin 0.2%, tranexamic acid 0.05%, O- cymene -5- alcohol 0.01%, potassium nitrate 3%, Rhizoma Zingiberis zerumbet
Extract 0.1%, NMF 60%, rubbing agent 30%, thickener 0.5%, foaming agent 1.8%, sweetener 0.1%, pH regulations
Agent 0.1%, spices 0.1%, the deionized water of surplus；
Wherein, the Cordyceps militaris elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris, and the Cordyceps militaris carries
The weight of the thing and fruiting bodies of cordyceps militaris ratio is taken to be：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=92：8；The NMF is sorb
The mixture of sugar alcohol and propane diols；The thickener is the mixture in sodium carboxymethylcellulose and xanthans；The foaming agent
For Cocoamidopropyl betaine and the mixture of lauryl sodium sulfate；The rubbing agent is calcium carbonate and superfine silicon dioxide
Mixture, superfine silicon dioxide it is described shield gum healing toothpaste preparing raw material in weight percentage be 4%；The sweet tea
Taste agent is STEVIA REBAUDIANA；The spices is lemon oil；The pH adjusting agent is ATSP.
Embodiment 4
A kind of embodiment of shield gum healing toothpaste of the present invention, include the preparing raw material of following weight percentage：Pupa
Lungfit 3%, allantoin 0.8%, tranexamic acid 0.08%, O- cymene -5- alcohol 0.08%, potassium nitrate 4%, Rhizoma Zingiberis zerumbet carry
Take thing 0.5%, NMF 45%, rubbing agent 20%, thickener 2%, foaming agent 2%, sweetener 1%, pH adjusting agent 2%, perfume
The deionized water of material 1% and surplus；
Wherein, the Cordyceps militaris elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris, and the Cordyceps militaris carries
The weight of the thing and fruiting bodies of cordyceps militaris ratio is taken to be：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=85：15；NMF is sorbose
The mixture of alcohol and glycerine；The thickener is carbomer；The foaming agent is sodium lauroyl sarcosine, lauroyl methyl ox sulphur
The mixture of sour sodium and lauryl sodium sulfate；The rubbing agent is the mixture of precipitated silica and superfine silicon dioxide,
Weight percentage of the superfine silicon dioxide in the preparing raw material of the shield gum healing toothpaste is 6%；The sweetener is sugar
Smart sodium；The spices is orange oil；The pH adjusting agent is ATSP.
Embodiment 5
A kind of embodiment of shield gum healing toothpaste of the present invention, include the preparing raw material of following weight percentage：Pupa
Lungfit 3%, allantoin 0.1%, tranexamic acid 0.1%, O- cymene -5- alcohol 0.05%, potassium nitrate 5%, Rhizoma Zingiberis zerumbet carry
Take thing 0.1%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener 1%, pH adjusting agent 2%, perfume
The deionized water of material 1% and surplus；
Wherein, the Cordyceps militaris elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris, and the Cordyceps militaris carries
The weight of the thing and fruiting bodies of cordyceps militaris ratio is taken to be：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=90：10；NMF is sorbose
The mixture of alcohol and glycerine；The thickener is carbomer；The foaming agent is sodium lauroyl sarcosine, lauroyl methyl ox sulphur
The mixture of sour sodium and lauryl sodium sulfate；The rubbing agent is the mixture of precipitated silica and superfine silicon dioxide,
Weight percentage of the superfine silicon dioxide in the preparing raw material of the shield gum healing toothpaste is 4%；The sweetener is sugar
Smart sodium；The spices is orange oil；The pH adjusting agent is ATSP.
Embodiment 6
A kind of embodiment of shield gum healing toothpaste of the present invention, the present embodiment shield gum healing toothpaste protect gum with embodiment 5
The difference of the content that the difference is that only Cordyceps militaris elite of healing toothpaste, the pupa worm of shield gum healing toothpaste described in the present embodiment
Weight percentage of the careless elite in the preparing raw material of toothpaste is 5%.
Embodiment 7
A kind of embodiment of shield gum healing toothpaste of the present invention, the present embodiment shield gum healing toothpaste protect gum with embodiment 5
The difference of the content that the difference is that only Cordyceps militaris elite of healing toothpaste, the pupa worm of shield gum healing toothpaste described in the present embodiment
Weight percentage of the careless elite in the preparing raw material of toothpaste is 4%.
Embodiment 8
A kind of embodiment of shield gum healing toothpaste of the present invention, the present embodiment shield gum healing toothpaste protect gum with embodiment 5
The difference of the content that the difference is that only Cordyceps militaris elite of healing toothpaste, the pupa worm of shield gum healing toothpaste described in the present embodiment
Weight percentage of the careless elite in the preparing raw material of toothpaste is 2%.
Embodiment 9
A kind of embodiment of shield gum healing toothpaste of the present invention, the present embodiment shield gum healing toothpaste protect gum with embodiment 5
The difference of the content that the difference is that only Cordyceps militaris elite of healing toothpaste, the pupa worm of shield gum healing toothpaste described in the present embodiment
Weight percentage of the careless elite in the preparing raw material of toothpaste is 1%.
Embodiment 10
A kind of embodiment of shield gum healing toothpaste of the present invention, the present embodiment shield gum healing toothpaste protect gum with embodiment 5
The difference of the content that the difference is that only Cordyceps militaris elite of healing toothpaste, the pupa worm of shield gum healing toothpaste described in the present embodiment
Weight percentage of the careless elite in the preparing raw material of toothpaste is 0.1%.
Embodiment 11
A kind of embodiment of shield gum healing toothpaste of the present invention, the preparing raw material and embodiment of toothpaste described in the present embodiment
5 weight that the difference is that only Cordyceps militaris extract and fruiting bodies of cordyceps militaris than difference, Cordyceps militaris described in the present embodiment
The weight of extract and fruiting bodies of cordyceps militaris ratio is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=99.9：0.01.
Embodiment 12
A kind of embodiment of shield gum healing toothpaste of the present invention, the preparing raw material and embodiment of toothpaste described in the present embodiment
5 weight that the difference is that only Cordyceps militaris extract and fruiting bodies of cordyceps militaris than difference, Cordyceps militaris described in the present embodiment
The weight of extract and fruiting bodies of cordyceps militaris ratio is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=95：5.
Embodiment 13
A kind of embodiment of shield gum healing toothpaste of the present invention, the preparing raw material and embodiment of toothpaste described in the present embodiment
5 weight that the difference is that only Cordyceps militaris extract and fruiting bodies of cordyceps militaris than difference, Cordyceps militaris described in the present embodiment
The weight of extract and fruiting bodies of cordyceps militaris ratio is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=92：8.
Embodiment 14
A kind of embodiment of shield gum healing toothpaste of the present invention, the preparing raw material and embodiment of toothpaste described in the present embodiment
5 weight that the difference is that only Cordyceps militaris extract and fruiting bodies of cordyceps militaris than difference, Cordyceps militaris described in the present embodiment
The weight of extract and fruiting bodies of cordyceps militaris ratio is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=85：15.
Embodiment 15
A kind of embodiment of shield gum healing toothpaste of the present invention, the preparing raw material and embodiment of toothpaste described in the present embodiment
5 weight that the difference is that only Cordyceps militaris extract and fruiting bodies of cordyceps militaris than difference, Cordyceps militaris described in the present embodiment
The weight of extract and fruiting bodies of cordyceps militaris ratio is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=80：20.
Comparative example 1
A kind of comparative example of shield gum healing toothpaste of the present invention, the preparing raw material and embodiment of toothpaste described in this comparative example
5 difference is, without Cordyceps militaris elite, allantoin, tranexamic acid, O- umbrellas in the preparing raw material of toothpaste described in this comparative example
Flower hydrocarbon -5- alcohol and Rhizoma Zingiberis zerumbet extract, i.e. toothpaste described in this comparative example include the preparing raw material of following weight percentage：Nitric acid
Potassium 5%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener 1%, pH adjusting agent 2%, spices 1%
With the deionized water of surplus.
Comparative example 2
A kind of comparative example of shield gum healing toothpaste of the present invention, the preparing raw material and embodiment of toothpaste described in this comparative example
5 difference is, without Cordyceps militaris elite, Rhizoma Zingiberis zerumbet extract and O- umbrellas flower in the preparing raw material of toothpaste described in this comparative example
Hydrocarbon -5- alcohol, i.e. toothpaste described in this comparative example include the preparing raw material of following weight percentage：Allantoin 0.1%, tranexamic acid
0.1%th, potassium nitrate 5%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener 1%, pH adjusting agent
2%th, the deionized water of spices 1% and surplus.
Comparative example 3
A kind of comparative example of shield gum healing toothpaste of the present invention, the preparing raw material and embodiment of toothpaste described in this comparative example
5 difference is, in the preparing raw material of toothpaste described in this comparative example without allantoin, tranexamic acid, O- cymene -5- alcohol and
Toothpaste includes the preparing raw material of following weight percentage described in Rhizoma Zingiberis zerumbet extract, i.e. this comparative example：Cordyceps militaris elite 3%,
Potassium nitrate 5%, Rhizoma Zingiberis zerumbet extract 0.1%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener
1%th, the deionized water of pH adjusting agent 2%, spices 1% and surplus.
Comparative example 4
A kind of comparative example of shield gum healing toothpaste of the present invention, the preparing raw material and embodiment of toothpaste described in this comparative example
5 difference is that Cordyceps militaris elite, allantoin, tranexamic acid and O- are free of in the preparing raw material of toothpaste described in this comparative example
Cymene -5- alcohol, i.e. toothpaste described in this comparative example include the preparing raw material of following weight percentage：Potassium nitrate 5%, Rhizoma Zingiberis zerumbet
Extract 0.1%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener 1%, pH adjusting agent 2%,
The deionized water of spices 1% and surplus.
Comparative example 5
A kind of comparative example of shield gum healing toothpaste of the present invention, the preparing raw material and embodiment of toothpaste described in this comparative example
5 difference is, without Cordyceps militaris elite, allantoin, tranexamic acid and red in the preparing raw material of toothpaste described in this comparative example
Toothpaste includes the preparing raw material of following weight percentage described in ball ginger extract, i.e. this comparative example：O- cymene -5- alcohol
0.05%th, potassium nitrate 5%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener 1%, pH adjusting agent
2%th, the deionized water of spices 1% and surplus.
Comparative example 6
A kind of comparative example of shield gum healing toothpaste of the present invention, the preparing raw material and embodiment of toothpaste described in this comparative example
The difference of 5 content that the difference is that only Cordyceps militaris elite, the Cordyceps militaris elite of shield gum healing toothpaste described in this comparative example
Weight percentage in the preparing raw material of toothpaste is 6%.
Comparative example 7
A kind of comparative example of shield gum healing toothpaste of the present invention, the preparing raw material and embodiment of toothpaste described in this comparative example
5 weight that the difference is that only Cordyceps militaris extract and fruiting bodies of cordyceps militaris than difference, Cordyceps militaris described in this comparative example
The weight of extract and fruiting bodies of cordyceps militaris ratio is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=100:0.
Comparative example 8
A kind of comparative example of shield gum healing toothpaste of the present invention, the preparing raw material and embodiment of toothpaste described in this comparative example
5 weight that the difference is that only Cordyceps militaris extract and fruiting bodies of cordyceps militaris than difference, Cordyceps militaris described in this comparative example
The weight of extract and fruiting bodies of cordyceps militaris ratio is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=75:25.
Embodiment 16
Described to embodiment 1~15 shield gum healing toothpaste and 1~8 toothpaste of comparative example are for common several thin in oral cavity
Bacterium carries out antibacterial test.
Antibacterial method of testing：According to《Disinfection technology standard》2.1.8. anti-(suppression) equal test method, passes through third party's machine
Structure is tested.
The preparation of bacteria inhibition tablet：In the sterilized petri dishes of cleaning, a diameter of 5mm is made, thickness is no more than the suppression of 4mm disks (block)
Microbial inoculum original cream piece, one group of every 4 (blocks).
The preparation of negative control piece：Take sterile dry filter paper piece, every be added dropwise it is standby after sterile distilled water.
The inoculation of test organisms：Concentration is dipped as 5 × 10 with sterile cotton swab5Cfu/ml~5 × 106Cfu/ml test organisms hangs
Liquid, nutrient agar planar surface uniformly smear 3 times, often smear 1 time, flat board should rotate 60 °, finally by cotton swab around
Plate edge is smeared one week, is covered plate, is put drying at room temperature 5min.
Bacteriostatic agent print is placed with：Experiment is placed with 1 microbiological contamination flat board every time, and each flat board is placed with the examination of 4 same test groups
Test print, 1 negative control piece, totally 5.It is placed with aseptic nipper coupongs in planar surface.Between each print center apart
More than 25mm, the periphery with flat board is at a distance of more than 15mm.After being placed with, with the light pressure-like piece of aseptic nipper, it is set to be close to flat board
Surface.Plate is covered, puts 37 DEG C of incubators, culture 16h~18h observation results.With the direct of vernier caliper measurement antibacterial ring size and remember
Record, experiment are repeated 3 times.
The bacterial strain of this test has selected common oral cavity pathogen：Staphylococcus aureus, streptococcus mutans and gum
Porphyrin monococcus.
Antibacterial test evaluation standard：Inhibition zone diameter is more than 7mm person, has been judged to bacteriostasis；Inhibition zone diameter be less than or
Equal to 7mm person, no bacteriostasis is judged to.The antibacterial test result of 1~6 toothpaste of embodiment 1~10 and comparative example is shown in Table 1,
Embodiment 5 and the antibacterial test comparison of 1~5 toothpaste of comparative example are shown in accompanying drawing 1~3, embodiment 5,11~15 and comparative example 7,8
The antibacterial test result of the toothpaste is shown in Table 2.
The antibacterial test result of 1~6 toothpaste of the embodiment 1~10 of table 1 and comparative example
As it can be seen from table 1 the shield gum of embodiment 1~10 heals toothpaste to staphylococcus aureus, streptococcus mutans
It is better than the fungistatic effect of 1~6 toothpaste of comparative example with the fungistatic effect of porphyromonas monococcus, especially from the embodiment of Fig. 1~3
5 can show that the fungistatic effect of toothpaste described in embodiment 5 is more than comparative example 1~5 with the contrast of the fungistatic effect of comparative example 1~5
Add allantoin, tranexamic acid, Cordyceps militaris elite, potassium nitrate, O- cymene -5- alcohol and Rhizoma Zingiberis zerumbet extract it is therein a kind of or
The fungistatic effect of several toothpaste, illustrate allantoin, tranexamic acid, Cordyceps militaris elite, potassium nitrate, O- cymene -5- alcohol and red
Ball ginger extract compounds in certain proportion can play a part of Synergistic.From embodiment 5~10 and comparative example 6
Fungistatic effect comparative example can be drawn, with the increase of the addition of Cordyceps militaris elite, fungistatic effect increases, but with Cordyceps militaris
After weight percentage of the elite in toothpaste preparing raw material is more than 5%, with the increase of addition, fungistatic effect increase does not show
Write.
The embodiment 5,11~15 of table 2 and comparative example 7, the antibacterial test result of 8 toothpaste
From table 2 it can be seen that in the case where Cordyceps militaris elite content is certain, with the increasing of fruiting bodies of cordyceps militaris content
Greatly, the fungistatic effect of made toothpaste is in the trend for first increasing and reducing afterwards, and real in Cordyceps militaris extract and Cordyceps militaris
The weight ratio of body is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=85~92：Effect reaches optimal when 8~15.
Embodiment 17
Clinical test, specific testing program are carried out to shield gum healing toothpaste of the present invention and 1~5 toothpaste of comparative example
It is as follows：
First, testing program
Double-blind randomized clinical trial designs, aspirations of the collection 139 with different degrees of gum redness bleeding problems by
Examination person, trial volunteer's age distribution at 15~58 years old, by subject be randomly divided into test group and control group I, II, III, IV,
V, the wherein people of test group 25, the people of control group I 23, the people of control group II 23, the people of control group III 24, the people of control group IV 23, control group V
21 people, test group and control group I, II, III, IV, V respectively using using shield gum healing toothpaste and comparative example 1 of the present invention~
5 toothpaste, tooth of trial volunteer when using toothpaste 4 weeks and 8 weeks is checked using the method for Oral epidemiological investigation
With the index of correlation of gum.
2nd, application method
Toothbrush：Soft wire type toothbrush；
Dosage：Test group, the subject of control group I~V are brushed teeth 2 times sooner or later daily, use 2 grams of toothpaste every time.
3rd, observation item and index
1st, gingival index (GI)
Check gingival margin near, it is remote in, cheek side, the situation in 4 regions of tongue side, be divided into 0~3 grade of standard, 0 point of (gum
Normally)；1 point (not bleeding is examined in gum mild inflammation, color mild change, Mild edema, spy)；2 points of (gum moderate inflammation, colors
Bleeding is examined in red, oedema, light, spy)；3 points (gingivitis is obvious, red and swollen, there is ulcer, automatic hemorrhagic tendency).
2nd, gingival sulcus bleeding index (SBI)
Check gingival margin near, it is remote in, cheek side, the situation in 4 regions of tongue side, be divided into 4 grades, 1 point (not bleeding)；2 points
(bleeding during light spy gingival sulcus, gum outward appearance are normal)；3 points (bleeding when visiting gingival sulcus, gum redden, no swelling)；4 points (gum has ulcer
Or other symptoms).
3rd, plaque index (PLI)
It is divided into 4 grades according to bacterial plaque amount, 0 point (Yin Yuan areas are without bacterial plaque)；1 point (visual examination without bacterial plaque, but can be in free gum with probe
And proximity scrapes thin layer bacterial plaque)；2 points (in gingival pocket, dissociate gum area or the soft deposit adjacent to the visible moderate bulk amount of facing
Thing)；3 points (in gingival pocket or free gum area and neighbouring facing have a large amount of soft deposit things).
4th, test result
GI, SBI, PLI value take the average value of trial volunteer's situation in every group, and result of the test is shown in Table 3~5.
The test group of table 3 and the GI values of control group compare
| Test group | Before experiment | After 4 weeks | After 8 weeks |
| Test group | 1.70±0.65 | 1.15±0.46 | 0.62±0.57 |
| Control group I | 1.58±0.38 | 1.52±0.45 | 1.44±0.54 |
| Control group II | 1.66±0.47 | 1.52±0.49 | 1.13±0.60 |
| Control group III | 1.70±0.37 | 1.58±0.38 | 1.05±0.49 |
| Control group IV | 1.59±0.88 | 1.45±0.59 | 1.11±0.37 |
| Control group V | 1.60±0.55 | 1.45±0.43 | 0.93±0.67 |
The test group of table 4 and the SBI values of control group compare
| Test group | Before experiment | After 4 weeks | After 8 weeks |
| Test group | 3.37±0.47 | 2.15±0.33 | 1.37±0.51 |
| Control group I | 3.45±0.73 | 3.33±0.57 | 3.12±0.45 |
| Control group II | 3.52±0.45 | 3.02±0.44 | 2.81±0.20 |
| Control group III | 3.42±0.64 | 2.89±0.59 | 2.76±0.54 |
| Control group IV | 3.39±0.98 | 2.94±0.45 | 2.83±0.61 |
| Control group V | 3.12±0.51 | 2.55±0.70 | 2.36±0.46 |
The test group of table 5 and the PLI values of control group compare
From table 3~5 as can be seen that and comparative example 1~5 addition allantoin, tranexamic acid, Cordyceps militaris elite, potassium nitrate
Compared with O- cymene -5- alcohol one or more of toothpaste therein, can be effective using shield gum healing toothpaste of the present invention
Gingivitis is treated, more effectively treats bleeding gums, swelling and pain relieving, and test group is compared with control group, has significant difference
(P ＜ 0.05).
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than the present invention is protected
The limitation of scope is protected, although being explained in detail with reference to preferred embodiment to the present invention, one of ordinary skill in the art should
Understand, technical scheme can be modified or equivalent substitution, without departing from the essence of technical solution of the present invention
And scope.
Claims (10)
1. one kind shield gum healing toothpaste, it is characterised in that include Cordyceps militaris elite, allantoin, tranexamic acid, O- cymenes -5-
Alcohol, potassium nitrate and Rhizoma Zingiberis zerumbet extract；The Cordyceps militaris elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris.
2. shield gum healing toothpaste as claimed in claim 1, it is characterised in that the shield gum healing toothpaste includes following weight percent
The preparing raw material of content：Cordyceps militaris elite 0.1~5%, allantoin 0.1~2%, tranexamic acid 0.05~0.1%, O- umbrellas flower
Hydrocarbon -5- alcohol 0.01~0.1%, potassium nitrate 3~10% and Rhizoma Zingiberis zerumbet extract 0.1~1%.
3. shield gum healing toothpaste as claimed in claim 1, it is characterised in that the shield gum healing toothpaste includes following weight percent
The preparing raw material of content：Cordyceps militaris elite 0.5~3%, allantoin 0.2~0.8%, tranexamic acid 0.05~0.08%, O- umbrellas
Flower hydrocarbon -5- alcohol 0.05~0.08%, potassium nitrate 3~5% and Rhizoma Zingiberis zerumbet extract 0.1~0.5%.
4. shield gum healing toothpaste as claimed in claim 1, it is characterised in that the Cordyceps militaris extract and fruiting bodies of cordyceps militaris
Weight ratio is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=80~99.9：0.01~20；Preferably, the Cordyceps militaris extract
Weight ratio with fruiting bodies of cordyceps militaris is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=85~92：8~15.
5. shield gum healing toothpaste as claimed in claim 1, it is characterised in that the preparing raw material of the shield gum healing toothpaste also includes
NMF, rubbing agent, thickener and foaming agent.
6. shield gum healing toothpaste as claimed in claim 5, it is characterised in that in the preparing raw material of the shield gum healing toothpaste, institute
The weight percentage for stating NMF is 40~60%, and the weight percentage of the rubbing agent is 14~30%, the thickening
The weight percentage of agent is 0.5~3%, and the weight percentage of the foaming agent is 1.8~3%.
7. shield gum healing toothpaste as claimed in claim 5, it is characterised in that the foaming agent is amino acid surfactant and two
Mixture of at least one of the property surfactant with lauryl sodium sulfate.
8. shield gum healing toothpaste as claimed in claim 5, it is characterised in that the foaming agent is sodium lauroyl sarcosine, bay
At least one of acyl methyl taurine sodium and Cocoamidopropyl betaine and the mixture of lauryl sodium sulfate.
9. shield gum healing toothpaste as claimed in claim 5, it is characterised in that the rubbing agent is precipitated silica, ultra-fine two
At least one of silica, calcium monohydrogen phosphate and calcium carbonate；Preferably, the rubbing agent is precipitated silica, calcium monohydrogen phosphate
With the mixture of at least one of calcium carbonate with superfine silicon dioxide, wherein, in the preparing raw material of the shield gum healing toothpaste,
The weight percentage of superfine silicon dioxide is 2~6%.
10. shield gum healing toothpaste as claimed in claim 5, it is characterised in that the thickener is sodium carboxymethylcellulose, card ripple
At least one of nurse and xanthans；The NMF is at least one in D-sorbite, glycerine, polyethylene glycol and propane diols
Kind.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108379139A (en) * | 2018-03-07 | 2018-08-10 | 济川药业集团有限公司 | A kind of toothpaste and its preparation method and application of anti-treating dental ulcer |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101502482A (en) * | 2009-03-27 | 2009-08-12 | 玉溪健坤生物药业有限公司 | Toothpaste containing coenzyme Q10 and preparation method thereof |
| US20100098733A1 (en) * | 2008-10-16 | 2010-04-22 | Novan, Inc. | Nitric oxide releasing particles for oral care applications |
| US20110076240A1 (en) * | 2008-04-18 | 2011-03-31 | Day Donal F | Antifungal and Anti-Cariogenic Cellobio-Oligosaccharides Produced by Dextransucrase |
| US20130108561A1 (en) * | 2011-10-31 | 2013-05-02 | T.F.H. Publications, Inc. | Compositions for improving the oral health of animals, methods using the same, and pet treats incorporating the same |
| CN103766545A (en) * | 2014-01-02 | 2014-05-07 | 隋新 | Preparation method of cordyceps militaris extractive-rich cordyceps militaris tea |
| CN104666621A (en) * | 2015-02-03 | 2015-06-03 | 湖南炎帝生物工程有限公司 | Traditional Chinese medicine composition playing roles of stopping bleeding, diminishing inflammations and preventing bacteria and toothpaste containing same |
| CN106924106A (en) * | 2015-12-28 | 2017-07-07 | 天津金士力佳友日化用品有限公司 | A kind of toothpaste for suppressing bacterial plaque and mitigate gingivitis |
-
2017
- 2017-07-28 CN CN201710635736.XA patent/CN107362112B/en not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110076240A1 (en) * | 2008-04-18 | 2011-03-31 | Day Donal F | Antifungal and Anti-Cariogenic Cellobio-Oligosaccharides Produced by Dextransucrase |
| US20100098733A1 (en) * | 2008-10-16 | 2010-04-22 | Novan, Inc. | Nitric oxide releasing particles for oral care applications |
| CN101502482A (en) * | 2009-03-27 | 2009-08-12 | 玉溪健坤生物药业有限公司 | Toothpaste containing coenzyme Q10 and preparation method thereof |
| US20130108561A1 (en) * | 2011-10-31 | 2013-05-02 | T.F.H. Publications, Inc. | Compositions for improving the oral health of animals, methods using the same, and pet treats incorporating the same |
| CN103766545A (en) * | 2014-01-02 | 2014-05-07 | 隋新 | Preparation method of cordyceps militaris extractive-rich cordyceps militaris tea |
| CN104666621A (en) * | 2015-02-03 | 2015-06-03 | 湖南炎帝生物工程有限公司 | Traditional Chinese medicine composition playing roles of stopping bleeding, diminishing inflammations and preventing bacteria and toothpaste containing same |
| CN106924106A (en) * | 2015-12-28 | 2017-07-07 | 天津金士力佳友日化用品有限公司 | A kind of toothpaste for suppressing bacterial plaque and mitigate gingivitis |
Non-Patent Citations (1)
| Title |
|---|
| 潘超美: "《中国民间生草药原色图谱.下册》", 31 March 2015, 广东科技出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108379139A (en) * | 2018-03-07 | 2018-08-10 | 济川药业集团有限公司 | A kind of toothpaste and its preparation method and application of anti-treating dental ulcer |
| CN108379139B (en) * | 2018-03-07 | 2020-12-08 | 济川药业集团有限公司 | Toothpaste for preventing and treating dental ulcer and preparation method and application thereof |
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