CN110538318A - Spray for preventing and controlling oral helicobacter pylori and preparation method thereof - Google Patents
Spray for preventing and controlling oral helicobacter pylori and preparation method thereof Download PDFInfo
- Publication number
- CN110538318A CN110538318A CN201910925206.8A CN201910925206A CN110538318A CN 110538318 A CN110538318 A CN 110538318A CN 201910925206 A CN201910925206 A CN 201910925206A CN 110538318 A CN110538318 A CN 110538318A
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- Prior art keywords
- spray
- helicobacter pylori
- preventing
- lysozyme
- ovotransferrin
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- 241000590002 Helicobacter pylori Species 0.000 title claims abstract description 24
- 229940037467 helicobacter pylori Drugs 0.000 title claims abstract description 24
- 239000007921 spray Substances 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 21
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 21
- 239000000243 solution Substances 0.000 claims description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 16
- 102000016943 Muramidase Human genes 0.000 claims description 13
- 108010014251 Muramidase Proteins 0.000 claims description 13
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims description 13
- 239000004325 lysozyme Substances 0.000 claims description 13
- 235000010335 lysozyme Nutrition 0.000 claims description 13
- 229960000274 lysozyme Drugs 0.000 claims description 13
- 108010026206 Conalbumin Proteins 0.000 claims description 12
- 244000046738 asparagus lettuce Species 0.000 claims description 12
- 235000006705 asparagus lettuce Nutrition 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 9
- 239000002994 raw material Substances 0.000 claims description 9
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 7
- 241000220317 Rosa Species 0.000 claims description 7
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 7
- 239000004359 castor oil Substances 0.000 claims description 7
- 235000019438 castor oil Nutrition 0.000 claims description 7
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 7
- 229940082477 moringa oleifera leaf extract Drugs 0.000 claims description 7
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 7
- 235000010234 sodium benzoate Nutrition 0.000 claims description 7
- 239000004299 sodium benzoate Substances 0.000 claims description 7
- 239000000600 sorbitol Substances 0.000 claims description 7
- 229940013618 stevioside Drugs 0.000 claims description 7
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 7
- 235000019202 steviosides Nutrition 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 239000008367 deionised water Substances 0.000 claims description 6
- 229910021641 deionized water Inorganic materials 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 230000002265 prevention Effects 0.000 claims description 6
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical group O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 claims description 5
- 235000011347 Moringa oleifera Nutrition 0.000 claims description 5
- 229940117916 cinnamic aldehyde Drugs 0.000 claims description 5
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 claims description 5
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 3
- 244000179886 Moringa oleifera Species 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 239000003595 mist Substances 0.000 claims description 2
- 239000011259 mixed solution Substances 0.000 claims description 2
- 240000002547 Rosa roxburghii Species 0.000 claims 3
- 235000000640 Rosa roxburghii Nutrition 0.000 claims 3
- 210000000214 mouth Anatomy 0.000 abstract description 12
- 239000000668 oral spray Substances 0.000 abstract description 3
- 230000036541 health Effects 0.000 abstract description 2
- 238000002474 experimental method Methods 0.000 description 9
- 230000003115 biocidal effect Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 235000013399 edible fruits Nutrition 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 241000220215 Moringa Species 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 229940041678 oral spray Drugs 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 102000019197 Superoxide Dismutase Human genes 0.000 description 1
- 108010012715 Superoxide dismutase Proteins 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000005429 filling process Methods 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 231100000405 induce cancer Toxicity 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000004223 radioprotective effect Effects 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 229960003885 sodium benzoate Drugs 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 208000018556 stomach disease Diseases 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01017—Lysozyme (3.2.1.17)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
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- Life Sciences & Earth Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Epidemiology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Immunology (AREA)
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Abstract
The invention discloses a spray for preventing and controlling oral helicobacter pylori and a preparation method thereof, and particularly relates to the technical field of oral sprays. The invention can inhibit or eliminate helicobacter pylori in oral cavity, keep oral health and remove oral peculiar smell.
Description
Technical Field
the invention belongs to the technical field of oral cavity sprays, and particularly relates to an oral cavity helicobacter pylori prevention and control spray and a preparation method thereof.
background
Helicobacter pylori in the oral cavity is a bacterium in the oral cavity and the stomach, can cause stomach diseases, often causes chronic gastrointestinal diseases and gastric ulcer, and can cause malignant lesion and induce cancer if measures are not taken for treatment in time.
the existing common treatment method adopts antibiotic treatment, the long-term antibiotic treatment has large damage to human bodies and is easy to generate resistance, and in addition, antibiotic pills are difficult to swallow for some people. Therefore, it is important to replace the medicine with the oral spray, and the existing common oral spray generally has the functions of antibiosis and antiphlogosis, but has poor effect on preventing and controlling the helicobacter pylori in the oral cavity.
therefore, a spray for preventing and controlling helicobacter pylori in oral cavity and a preparation method thereof are urgently needed to solve the existing problems.
disclosure of Invention
The invention aims to provide a spray for preventing and controlling oral helicobacter pylori and a preparation method thereof, and the prepared spray can inhibit or eliminate the helicobacter pylori and remove oral peculiar smell so as to keep oral health.
The technical scheme adopted by the invention is as follows:
A spray for preventing and controlling helicobacter pylori in oral cavity comprises ovotransferrin, lysozyme, Moringa oleifera leaf extract and Asparagus lettuce extract. The ovotransferrin and the lysozyme can inhibit the growth of microorganisms in the oral cavity, especially helicobacter pylori, the moringa oleifera leaf extract can keep the oral cavity fresh and free from peculiar smell, and meanwhile, the liver can be strengthened, the immunity can be enhanced, and the asparagus lettuce extract has the effects of whitening and strengthening teeth.
Preferably, the mass percentages of the raw materials are as follows:
20-25% of ethanol, 5-15% of 70% sorbitol, 2.5-7.5% of glycerol, 0.5-1% of PEG-40 hydrogenated castor oil, 0.5-1% of essence, 0.05-0.2% of stevioside, 0.2-0.5% of sodium benzoate, 0.1-1% of ovotransferrin, 0.1-1% of lysozyme, 0.5-1% of moringa leaf extract, 0.5-1% of asparagus lettuce extract and the balance of deionized water, and the pH value of the solution obtained by mixing the raw materials is adjusted to 6.6-7.0 by using a proper amount of citric acid.
preferably, the essence is cinnamaldehyde.
Preferably, the mass percentages of the raw materials are as follows:
23% of ethanol, 10% of 70% of sorbitol, 5% of glycerol, 0.7% of PEG-40 hydrogenated castor oil, 0.8% of cinnamaldehyde, 0.1% of stevioside, 0.3% of sodium benzoate, 0.5% of ovotransferrin, 0.6% of lysozyme, 0.6% of moringa oleifera leaf extract, 0.7% of asparagus lettuce extract and the balance of deionized water, and the pH value of a mixed solution of the raw materials is adjusted to be 6.6-7.0 by using a proper amount of citric acid.
Preferably, the roxburgh rose fruit beverage also comprises roxburgh rose fruit, and the mass percentage of the roxburgh rose fruit is 1-5%. Fructus Rosae Normalis is rich in vitamin C, superoxide dismutase, etc., has active substances with antiaging and anticancer effects, and also has antiviral and radioprotective effects.
Preferably, the mass percent of the roxburgh rose is 3%.
A preparation method of a spray for preventing and controlling oral helicobacter pylori comprises the following steps:
s1, mixing the powder prepared from the roxburgh rose with the moringa leaf extract and the asparagus lettuce extract, adding the mixture into deionized water, uniformly mixing, heating to 70 ℃ until the mixture is dissolved, cooling the solution to room temperature, and adding ethanol, 70% sorbitol, glycerol and PEG-40 hydrogenated castor oil;
S2, dissolving ovotransferrin and lysozyme at 50 ℃, adding the dissolved ovotransferrin and lysozyme into the solution obtained in the step S1, and adding citric acid to adjust the pH value of the solution to 6.6-7.0;
s3, adding stevioside, sodium benzoate and essence into the solution obtained in the step S2, uniformly mixing, and filtering the solution through a filtering device to obtain the required product.
preferably, the filtering device of step S3 requires the mist droplets to be controlled to 5-10 μm.
Has the advantages that: can inhibit or eliminate helicobacter pylori in oral cavity, keep oral cavity healthy, and remove oral odor.
Detailed Description
example 1
Sprays of 1 group of control groups and 4 groups of experimental groups were prepared according to the following mixture ratio, and the sprays of the 4 groups of experimental groups were experiment 1, experiment 2, experiment 3 and experiment 4, respectively.
TABLE 1 raw material ratio and action of spray
The preparation process of the spray comprises the following steps:
Firstly, preparing contents:
(1) Mixing the powder prepared from fructus Rosae Normalis (weighing fructus Rosae Normalis according to mass ratio) with Moringa oleifera leaf extract and Asparagus lettuce extract (if there is no fructus Rosae Normalis in the formula, mixing the Moringa oleifera leaf extract and Asparagus lettuce extract), adding into water, mixing, heating to 70 deg.C for dissolving, cooling the solution to room temperature, adding ethanol and 70% sorbitol, glycerol, and PEG-40 hydrogenated castor oil;
(2) Dissolving egg into iron and lysozyme at 50 deg.C;
(3) Adding the step (2) into the step (1);
(4) adding citric acid to adjust the pH value of the solution to 6.6-7.0;
(5) finally adding stevioside, sodium benzoate and cinnamaldehyde;
(6) The solution is then filtered through a filter device, requiring droplets to be controlled at 5-10 μm.
Secondly, processing and assembling of the container and the valve system:
Cleaning, drying, and preheating to 120-. Dipping the mixture into plastic slurry while the mixture is hot to enable a layer of plastic slurry to be adhered below a bottleneck, inverting the mixture, and drying the mixture for 15 minutes at the temperature of 150 ℃ and 170 ℃ for later use.
The valve system was soaked in 75% ethanol for 24 hours and dried for use.
Thirdly, filling process:
Filling the solution prepared in the first step into a container at room temperature, then installing and tightly rolling a valve, and then pumping out the air in the container.
Example 3
Performance testing
The experimental method for inspecting the prevention and control of helicobacter pylori and removing the oral odor of the product comprises the following steps: 200 Hp positive patients are selected, oral hygiene environments are equivalent, age deviation is small, the patients are divided into a treatment group 1(40 cases), a treatment group 2(40 cases), a treatment group 3(40 cases) and a treatment group 4(40 cases) control group (40 cases), the treatment group 1, the treatment group 2, the treatment group 3 and the treatment group 4 are sprayed with the spray obtained by the experiment 1, the experiment 2, the experiment 3 and the experiment 4 in the example 2 respectively, 2 times (once in the morning and evening) are taken every day, the control group is sprayed with the spray obtained by the control group in the example 2, 2 times (once in the morning and evening) are taken every day, the using period is 1 month, and after 1 month of medicine stopping, the negative change rate and the oral odor removal condition are counted, and the results are as follows:
TABLE 2 test results for prevention and control of helicobacter pylori
The experimental data prove that the product has obvious effect, the ovotransferrin, the lysozyme, the moringa oleifera extract and the asparagus lettuce extract play an obvious role in the product, and the roxburgh rose can enhance the prevention and control effect.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (8)
1. the spray for preventing and controlling oral helicobacter pylori is characterized by comprising ovotransferrin, lysozyme, a moringa oleifera leaf extract and a asparagus lettuce extract.
2. The spray for preventing and controlling oral helicobacter pylori according to claim 1, wherein the mass percentages of the raw materials are as follows:
20-25% of ethanol, 5-15% of 70% sorbitol, 2.5-7.5% of glycerol, 0.5-1% of PEG-40 hydrogenated castor oil, 0.5-1% of essence, 0.05-0.2% of stevioside, 0.2-0.5% of sodium benzoate, 0.1-1% of ovotransferrin, 0.1-1% of lysozyme, 0.5-1% of moringa leaf extract, 0.5-1% of asparagus lettuce extract and the balance of deionized water, and the pH value of the solution obtained by mixing the raw materials is adjusted to 6.6-7.0 by using a proper amount of citric acid.
3. The spray for preventing and controlling oral helicobacter pylori according to claim 2, wherein the essence is cinnamaldehyde.
4. The spray for preventing and controlling oral helicobacter pylori according to claim 3, wherein the mass percentages of the raw materials are as follows:
23% of ethanol, 10% of 70% of sorbitol, 5% of glycerol, 0.7% of PEG-40 hydrogenated castor oil, 0.8% of cinnamaldehyde, 0.1% of stevioside, 0.3% of sodium benzoate, 0.5% of ovotransferrin, 0.6% of lysozyme, 0.6% of moringa oleifera leaf extract, 0.7% of asparagus lettuce extract and the balance of deionized water, and the pH value of a mixed solution of the raw materials is adjusted to be 6.6-7.0 by using a proper amount of citric acid.
5. the spray for preventing and controlling oral helicobacter pylori according to any one of claims 1 to 4, further comprising Rosa roxburghii, wherein the mass percentage of Rosa roxburghii is 1 to 5%.
6. the spray for preventing and controlling oral helicobacter pylori according to claim 5, wherein the mass percentage of the rosa roxburghii tratt is 3%.
7. the preparation method of the oral helicobacter pylori spray for prevention and control of claim 5, which is characterized by comprising the following steps:
S1, mixing the powder prepared from the roxburgh rose with the moringa leaf extract and the asparagus lettuce extract, adding the mixture into deionized water, uniformly mixing, heating to 70 ℃ until the mixture is dissolved, cooling the solution to room temperature, and adding ethanol, 70% sorbitol, glycerol and PEG-40 hydrogenated castor oil;
S2, dissolving ovotransferrin and lysozyme at 50 ℃, adding the dissolved ovotransferrin and lysozyme into the solution obtained in the step S1, and adding citric acid to adjust the pH value of the solution to 6.6-7.0;
s3, adding stevioside, sodium benzoate and essence into the solution obtained in the step S2, uniformly mixing, and filtering the solution through a filtering device to obtain the required product.
8. The spray for prevention and control of oral helicobacter pylori according to claim 7, wherein the filtering means of step S3 requires the mist to be controlled to 5-10 μm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910925206.8A CN110538318A (en) | 2019-09-27 | 2019-09-27 | Spray for preventing and controlling oral helicobacter pylori and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910925206.8A CN110538318A (en) | 2019-09-27 | 2019-09-27 | Spray for preventing and controlling oral helicobacter pylori and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN110538318A true CN110538318A (en) | 2019-12-06 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910925206.8A Pending CN110538318A (en) | 2019-09-27 | 2019-09-27 | Spray for preventing and controlling oral helicobacter pylori and preparation method thereof |
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| Country | Link |
|---|---|
| CN (1) | CN110538318A (en) |
Cited By (1)
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Application publication date: 20191206 |