CN109619248A - Quickly eliminate bad breath the sugar-free hard candy piece and preparation method thereof for removing helicobacter pylori - Google Patents
Quickly eliminate bad breath the sugar-free hard candy piece and preparation method thereof for removing helicobacter pylori Download PDFInfo
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- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000019533 nutritive sweetener Nutrition 0.000 description 1
- 244000039328 opportunistic pathogen Species 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229920006280 packaging film Polymers 0.000 description 1
- 239000012785 packaging film Substances 0.000 description 1
- 235000021485 packed food Nutrition 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 210000003695 paranasal sinus Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 210000001187 pylorus Anatomy 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000014860 sensory perception of taste Effects 0.000 description 1
- 229940007046 shigella dysenteriae Drugs 0.000 description 1
- 230000003997 social interaction Effects 0.000 description 1
- 235000021055 solid food Nutrition 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 206010044008 tonsillitis Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/48—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
- A23G3/366—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing microorganisms, enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
- A23G3/368—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing vitamins, antibiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/42—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/44—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
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- Polymers & Plastics (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
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- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Microbiology (AREA)
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- Confectionery (AREA)
Abstract
The invention belongs to field of food producing technology, and in particular to a kind of quickly to eliminate bad breath the sugar-free hard candy piece and preparation method thereof for removing helicobacter pylori, the raw material including following parts by weight: 20-30 parts of peppermint dry powder；55-65 parts of D-sorbite；5-10 parts of egg white lysozyme dry powder；0.2-1.5 parts of papain；5-10 parts of collagen；5-10 parts of amino acid；5-10 parts of small molecule Gly-His-Lys；0.05-0.07 parts of vitamin A；0.05-0.07 parts and vitamin E 0.05-0.07 parts of vitamin B.The sugar-free hard candy piece that the present invention is prepared can effectively kill the helicobacter pylori in oral cavity, thoroughly change oral cleaning, to accomplish the effect for purifying oral cavity, eliminating halitosis, fresh breath, has the function of edible, nutrition, antibacterial, sterilization, anti-inflammatory, to prevention canker sore, aphtha, gingivitis, halitosis, oral cavity cavity disease etc., there is remarkable effect and curative effect, and be a kind of sugarfree foods, obesity is not easily caused, is very beneficial for various people and the middle-aged and the old and children is edible.
Description
Technical field
The invention belongs to field of food producing technology, and in particular to a kind of quickly to eliminate bad breath removing helicobacter pylori
Sugar-free hard candy piece and preparation method thereof.
Background technique
Currently, candy available on the market is to be equipped with the food additive of part using granulated sugar and starch syrup as raw material mostly
Add agent to carry out processing formation, often eats this kind of candy and be easy to cause obesity because of its high heat, and be easy decayed tooth, to oral cavity
Health is also difficult to guarantee.With the development of economy, great change has occurred in improvement of living standard, the consumption idea of people, more
More focus on influence of the diet to own health level, food function is also had higher requirement, when healthy food has become
The needs in generation are changed into the mainstream of food products market gradually.
The key of sugarfree foods is in the definition of " sugar ".According to chinese national standard " pre-packaged food for special foods mark
Sign general rule " it provides, the requirement of " sugar-free " refers to that every 100 grams or 100 milliliters in solid or liquid food of sugar content is not higher than
0.5% (i.e. 0.5 gram).Sugarfree foods have increasingly been recognized and have been received by people as health-oriented products, with being not easy by people
Xylitol or the multi-sugar alcohol substitution that body absorbs easily cause decayed tooth, obesity, the simple sugars of hyperglycemia (sucrose, fructose and maltose
Deng), effect is exactly the sense of taste of sugar, and but the energy of simple sugars is not again good for health simultaneously.By to sugarfree foods
Solution is so that sugarfree foods also have mothproof tooth, prevent fertilizer it was recognized that sugarfree foods are not only merely the dedicated of diabetes patient
Fat effect, it is more young artificial oneself, parent be that child selects sugarfree foods to absolutely prove that sugar-free is the trend of health.
Halitosis refers to that from oral cavity or other cavitys full of air, the foul smell given out, it is tight such as nose, nasal sinus, pharynx
Ghost image rings the social interaction and mental health of people, and WHO reports halitosis as a kind of disease.Investigation display, in
State's halitosis illness rate is 27 .5%.And in western countries, then it is 50%.There are about the people of 10%-65% once to suffer from halitosis in the whole world.Halitosis
It is divided into true property halitosis, false halitosis and three kinds of halitosis neurosis；True property halitosis includes physiological halitosis, pathologic halitosis, Kou Yuan
Property halitosis and non-mouth source property halitosis；The reason of false halitosis includes three aspect of food, drug and oral hygiene；Halitosis neurosis master
If a kind of hysteria for thinking itself halitosis, especially prominent in the crowd for once suffering from halitosis caused by psychology.In view of oral cavity
Local factor is the main reason for forming halitosis, so product of the main exploitation based on oral care type both at home and abroad.State at present
The product of the elimination halitosis of inside and outside listing is mostly covered using aromatic (peppermint, vanillic aldehyde, fruity flavor etc.) cooking major ingredient
Oral peculiar smell, this kind of products include various chewing gums, chewing gum etc., after people are edible, though halitosis can be eliminated, are covered
Oral peculiar smell, but the time is of short duration, and the purpose for the treatment of both manifestation and root cause of disease is unable to reach for halitosis, to the not substantial effect of halitosis and
Meaning.Moreover, currently known various chewing gums are base by the glue sheet such as natural gum or glycerol resin all based on sweet taste mouthfeel
Material, is added various essence or flavor confect forms, not only nonnutritive, but also base-material cannot be eaten, moreover it is possible to generate secondary oral cavity
Unusual odor；Base-material is chewed after if do not dealt with, highly polluting environment.These chewing gums, which have, oneself has eaten perfume (or spice), Bie Renwen
The phenomenon that unpleasant mixing good and foul smells type implication, have: " mouth is not fragrant for chewing gum " is said, and is not had to the oral cleaning and cavity of people
There is much help；Also without the curative effect of prevention and treatment oral cavity cavity disease.
Therefore, develop a kind for the treatment of both manifestation and root cause of disease, it is safe and harmless eliminate bad breath sugar-free hard candy product, have to treatment halitosis important
Meaning, while also have sizable market prospects.
Summary of the invention
The object of the present invention is to provide a kind for the treatment of both manifestation and root cause of disease, safe and harmless it effectively can quickly eliminate bad breath removing H. pylori
Sugar-free hard candy piece of bacterium and preparation method thereof, the sugar-free hard candy piece for quickly eliminating bad breath removing helicobacter pylori can be killed effectively
Helicobacter pylori in oral cavity, thoroughly changes oral cleaning, to accomplish the work for purifying oral cavity, eliminating halitosis, fresh breath
With having the function of edible, nutrition, antibacterial, sterilization, anti-inflammatory, to prevention canker sore, aphtha, gingivitis, halitosis, oral cavity chamber
Tract disease etc. has remarkable effect and curative effect, and is a kind of sugarfree foods, does not easily cause obesity, free from environmental pollution, has very much
It is edible conducive to various people and the middle-aged and the old and children.
To achieve the above object, the present invention adopts the following technical scheme:
It is a kind of quickly to eliminate bad breath the sugar-free hard candy piece for removing helicobacter pylori, the raw material including following parts by weight:
20-30 parts of peppermint dry powder；55-65 parts of D-sorbite；5-10 parts of egg white lysozyme dry powder；0.2-1.5 parts of papain；Glue
Former albumen 5-10 parts；5-10 parts of amino acid；5-10 parts of small molecule Gly-His-Lys；0.05-0.07 parts of vitamin A；Vitamin B 0.05-
0.07 part and vitamin E 0.05-0.07 parts.
Above-mentioned quickly eliminates bad breath in the sugar-free hard candy piece for removing helicobacter pylori, and the peppermint dry powder is will be fresh
Peppermint clean up after squeeze the juice filtering, by filtrate at -10 DEG C~-25 DEG C vacuum freezedrying to get arrive peppermint dry powder.
Above-mentioned quickly eliminates bad breath in the sugar-free hard candy piece for removing helicobacter pylori, and the amino acid includes asparagus fern ammonia
One of acid, glutamic acid and arginine are a variety of.
Above-mentioned quickly eliminates bad breath in the sugar-free hard candy piece for removing helicobacter pylori, the vitamin A, vitamin B
Granularity with vitamin E is 500~800 mesh.
Above-mentioned quickly eliminates bad breath in the sugar-free hard candy piece for removing helicobacter pylori, the egg white lysozyme dry powder
Preparation method include the following steps:
1. taking egg white, clean, the water of 2~2.5 times of egg white volume amounts is added in egg white, stirs evenly, be heated to 60 DEG C, protects
Temperature reaction 3~5 minutes, is filtered to remove foreign protein,
2. cleaner liquid NaC03It is 8 that solution, which is adjusted to pH value, the acrylic acid of egg white quality 0.12~0.22% is added, in 3 DEG C~5 DEG C
Lower precipitating 22~25 hours, filtering；
3. the hydrochloric acid solution that 10~11 times of Sediment weight amount pH values are 6 is added in obtained precipitating to dissolve, and CaCl is added2,
CaCl2The amount of addition is consistent with the step amount that 2. middle acrylic acid is added；After reaction 1-2 hours, filtering；
4. obtained filtrate is through 0.22 micron of membrane filtration, then the ultrafiltration concentration centrifuge tube for being 5K through molecular cut off, ultrafiltration
Concentration；
5. the ethyl alcohol that volumetric concentration is 95% is added in concentrate, until the volume content of ethyl alcohol is 72%-75% in concentrate, so
It is precipitated 24 hours at -5 DEG C~-6 DEG C afterwards；
6. being deposited at -10 DEG C for obtaining is carried out vacuum freeze drying, the chicken that enzymatic activity recovery is 80-90% can be prepared by
Egg white lysozyme dry powder.
Described quickly eliminates bad breath the sugar-free hard candy piece for removing helicobacter pylori, and preparation method includes the following steps:
(1) various raw material for standby are taken in parts by weight；
(2) appropriate purified water is added in D-sorbite, is heated to 100 DEG C, dissolves 4~6min, is cooled to 30-40 DEG C after filtering
It is spare；
(3) slot is added in peppermint dry powder, collagen, amino acid, small molecule Gly-His-Lys, vitamin A, vitamin B and vitamin E
Formula mixing machine mixing 30-40min, obtains mixture；
(4) it will be put into blender, be stirred continuously, and egg white lysozyme dry powder is added obtained by step (2) and step (3)
And papain, it is dried after mixing to it, dry environment temperature is 35~45 DEG C, is dried to weight moisture content not
Greater than the 5% of total weight；
(5) raw material after drying is carried out by tabletting by tablet press machine, and is sealed and is packed with food bag, obtain finished product.
In the present invention, used peppermint dry powder be from peppermint (Mentha haplocalyx Briq.) in extract obtain
, peppermint is one of Chinese conventional Chinese medicine, it is pungent cool property sweating antipyretic medicine, controls influenza, headache, hot eyes, body heat, pharynx
The diseases such as larynx, gum swelling and pain.External application can control neuralgia, pruitus, fash and eczema etc..Usually with peppermint for tea, clear away heart-fire improving eyesight.
Peppermint contains menthol, the substance can fresh breath and have a variety of pharmacological properties, can be relieved abdominal pain, gall-bladder problem such as spasm, also have
There are antisepsis and sterilization, diuresis, resolving sputum, stomach invigorating and aid digestion and other effects.Peppermint is added in prepared sugar-free hard candy piece in the present invention,
There is antipathogenic composition in peppermint, alleviation toothache can be played, nourish the effect of gum, and can remove implication has holding implication clear
New effect improves problem of bad breath for a long time.And peppermint have heat-clearing except fire, wind-dispelling heat-dissipating, refresh oneself, throat,
The effect of the effect of promoting eruption, relieve stagnation, peppermint candy often contains helping digestion use, discongests wind-heat, pharynx-clearing throat-benefiting.Cold anemopyretic can be treated,
Headache, hot eyes, the diseases such as abscess of throat.
D-sorbite is white hygroscopic powder or crystalline powder, sheet or particle, has refrigerant sweet taste, sugariness is about sugarcane
The half of sugar, calorific value are close with sucrose.It is nutritive sweetener, wetting agent, chelating agent and stabilizer, is widely used in production food
In product.It is not converted into glucose in blood after D-sorbite is edible, is not also influenced by insulin, diabetes patient is suitble to use.
The effect that D-sorbite not only acts as sweetener in the present invention can also play the role of bonding in the production of hard candy.
Used egg white lysozyme work is it is currently understood that one of most clear lysozyme, lysozyme in the present invention
(lysozyme) muramidase (muramidase) or N-acetylmuramide lycanohydrlase (N-acetylmuramide are also known as
It glycanohydrlase), is a kind of alkaline enzyme that can be hydrolyzed and stick polysaccharide in pathogenic bacteria.Lysozyme is a kind of in food industry
The food natural bactericidal agent of high efficiency high security.Compared with chemical bactericide, inhibitor, it is protein, to human body without
Toxicity.Therefore lysozyme can be added in fresh T milk or milk powder in the food industry, enhances infant immunity;It can be added to
Beverage, cake, in meat products, can be with Shelf-life;As the preservative of packaging film, for the fresh-keeping etc. of fresh feed;
Lyase bacterium can be used for canker sore prevention infection and be used, and the gargle and toothpaste of lysozyme can also be made, can anti-caries.It is molten
Bacterium enzyme is clinically effective antiphlogistic, has antibacterial, antiviral, hemostasis, detumescence, analgesia, accelerates the functions such as tissue repair.
The antimicrobial spectrum of lysozyme is wider, is not only limited to G- bacterium, also has inhibitory effect to part G+ bacterium；Lysozyme conduct
Preservative is highly-safe.Lysozyme is a kind of native protein, and the food additives association of FAO/WTO in 1992 has been assert
It is safe that lysozyme is applied in food.Lysozyme can effectively hydrolytic bacteria cell wall peptide glycan, hydrolytic sites are
β -1.4 glycosidic bond between 1 carbon atom of -acetylmuramic acid (NAM) and 4 carbon atoms of N-Acetyl-D-glucosamine (NAG).
Peptide glycan is the main ingredient of bacteria cell wall, it is made of NAM, NAG and peptide " tail " (usually 4 amino acid), NAM with
NAG by β -1.4 glycosidic bond be connected, peptide " tail " is connected on the 3rd carbon atom of NAM by D- lactoyl carboxyl, peptide tail it
Between by peptide " bridge " (peptide bond or a few amino acid) connect, NAM, NAG, peptide " tail " and peptide " bridge " have collectively constituted peptide glycan
Multilayer network structure, as the skeleton of cell wall, any chemical bond rupture in above structure can all lead to bacteria cell wall
Damage.For gram-positive bacteria (G+), such as micrococcus luteus, hay bacillus or micrococcus lysodeikticus, with Gram-negative
Bacterium (G-), such as Escherichia coli, proteus, shigella dysenteriae, pneumobacillus, peptidoglycan content is different in cell wall, and G+ is thin
Bacterium cell wall almost all is made of peptide glycan, and it is peptide glycan that G- bacterium, which only has inner wall layer, and therefore, lysozyme is for destroying G+
The cell wall of bacterium is strong compared with G- bacterium.H. pylori Pseudomonas gram- bacteria uses egg white lysozyme conduct in the present invention
The raw material of hard candy, prepared hard candy piece can effectively kill helicobacter pylori.And egg used in the present invention
Clear lysozyme dry powder is that inventor is homemade, and egg white lysozyme dry powder enzymatic activity recovery obtained is high, and function and effect are good.
Papain is a kind of with very extensive proteolytic enzyme, and pure natural, safe and non-toxic element is answered in food processing industry
With extensive, belong to food additives, the drug containing papain can play anticancer, tumour, lymphatic leukemia, opportunistic pathogen and post
Infested, tubercle bacillus etc., can anti-inflammatory, cholagogue, analgesic, aid digestion.Papain can treat gynaecological disease, glaucoma, osteoproliferation,
The wound healing of rifle knife, blood group identification, insect bites etc. have anti-inflammatory, cholagogue, analgesic, aid digestion, raising immunity and other effects,
Papain removes tartar and calculus dentalis for making toothpaste, mouthwash, tooth powder etc., cleanable oral cavity.
Collagen protein powder, the i.e. powderous preparations of collagen.Collagen is the main component of skin, collagen egg in skin
White to account for 72%, 80% is collagen in corium, and collagen constitutes a fine and closely woven elasticated net in skin, locks water
Point, skin is support such as bracket.Collagen is one of important composition ingredient of human body protein, plays support organ, protection machine
The effect of body.In addition, collagen also has relatively broad application in field of food, collagen protein powder can supplement human body institute
The collagen of loss, in terms of improving skin, skin whitening, moisturizing, light spot are gone the effect of, have obtained the generally acknowledged of people, are one
The very popular health product of kind.
Small molecule Gly-His-Lys of the present invention can be by being commercially available, including agaric Gly-His-Lys, oat Gly-His-Lys, pawpaw small molecule
Gly-His-Lys and fructus lycii Gly-His-Lys etc..Small-molecular peptides are a kind of biochemical substances between a kind of amino acid and protein, it is than protein point
Son amount is small, bigger than amino acid molecular amount, is a segment of protein.It is connected between more than two amino acid with peptide bond, shape
At " amino acid chain " or " amino acid string " be just called peptide.Wherein, 10 are referred to as polypeptide with the peptide that upper amino acid forms, and
Just it is called oligopeptides by what 2 to 9 amino acid formed, is just called small-molecular peptides or small peptide by what 2 to 4 amino acid formed.Small point
Sub- peptide is the novel high nutrient of integration of drinking and medicinal herbs, has and improves immunity, eliminates disease root, extends the function such as human longevity
Effect.
The invention has the benefit that
1, the present invention is prepared quick using raw materials such as peppermint dry powder, egg white lysozyme dry powder, papain, collagens
It eliminates bad breath and removes the sugar-free hard candy piece of helicobacter pylori and can effectively kill helicobacter pylori in oral cavity, thoroughly change oral cavity
Cleaning has edible, nutrition, antibacterial, sterilization, anti-inflammatory to accomplish the effect for purifying oral cavity, eliminating halitosis, fresh breath
Function, dampness elimination addiction is dirty, eliminating stomach-fire, can achieve the purpose that treating both manifestation and root cause of disease to halitosis, to prevention canker sore, aphtha, gum
Inflammation, halitosis, oral cavity cavity disease etc. have remarkable effect and curative effect,
2, the vitamin vitamin A, vitamin B, the vitamin E that are added can not only supplement human body requirements in the present invention, can be with
It assists lysozyme and probiotics to remove bacterial plaque and spot, inhibits bleeding gums.The peppermint dry powder of addition can play alleviation toothache, grow
The effect of gum is supported, and implication can be removed to play the role of keeping breath freshening, improves problem of bad breath for a long time.This hair
The bright sugar-free hard candy piece being prepared, which not only offsets, has eliminated bad breath positive effect, also have it is clearing heat and detoxicating, discongest wind-heat, clearing benefit
Larynx, anti-inflammatory is antibacterial, improves the health-care efficacies such as immunity, has no toxic and side effect to human body, is a kind of safe health food.
3, what the present invention was prepared, which quickly eliminates bad breath the sugar-free hard candy piece for removing helicobacter pylori, has refrigerant sense, energy
Fresh breath can quickly eliminate halitosis, be free of sucrose, and sugar-free, low-calorie will not cause decayed tooth, fat or blood glucose rise,
It is a kind of sugarfree foods, does not easily cause obesity, is very beneficial for various people and the middle-aged and the old and children are edible, and convenient for taking
Band, instant edible directly melt, do not generate colloid residual contamination environment.
Specific embodiment
Embodiment 1
It is a kind of quickly to eliminate bad breath the sugar-free hard candy piece for removing helicobacter pylori, the raw material including following parts by weight:
20 parts of peppermint dry powder；55 parts of D-sorbite；5 parts of egg white lysozyme dry powder；0.2 part of papain；5 parts of collagen；Ammonia
5 parts of base acid；5 parts of small molecule Gly-His-Lys；0.05 part of vitamin A；0.05 part and 0.05 part of vitamin E of vitamin B.
The peppermint dry powder is filtering of squeezing the juice after cleaning up fresh mint, and filtrate is cold at -10 DEG C~-25 DEG C
Freeze vacuum drying to get peppermint dry powder is arrived；The amino acid is aspartic acid；Vitamin A, vitamin B and the Wei Sheng
The granularity of plain E is 500 mesh.
The preparation method of the egg white lysozyme dry powder includes the following steps:
1. taking egg white, clean, the water of 2 times of egg white volume amounts is added in egg white, stirs evenly, is heated to 60 DEG C, heat preservation is anti-
It answers 3 minutes, is filtered to remove foreign protein,
2. cleaner liquid NaC03It is 8 that solution, which is adjusted to pH value, and the acrylic acid of egg white quality 0.12% is added, and it is small that 25 are precipitated at 3 DEG C
When, filtering；
3. the hydrochloric acid solution that 10 times of Sediment weight amount pH values are 6 is added in obtained precipitating to dissolve, and CaCl is added2, CaCl2
The amount of addition is consistent with the step amount that 2. middle acrylic acid is added；After reaction 1 hour, filtering；
4. obtained filtrate is through 0.22 micron of membrane filtration, then the ultrafiltration concentration centrifuge tube for being 5K through molecular cut off, ultrafiltration
Concentration；
5. in concentrate be added volumetric concentration be 95% ethyl alcohol, until in concentrate ethyl alcohol volume content be 72%, then in-
It is precipitated 24 hours at 5 DEG C；
6. being deposited at -10 DEG C for obtaining is carried out vacuum freeze drying, the chicken that enzymatic activity recovery is 80-90% can be prepared by
Egg white lysozyme dry powder.
Described quickly eliminates bad breath the sugar-free hard candy piece for removing helicobacter pylori, and preparation method includes the following steps:
(1) various raw material for standby are taken in parts by weight；
(2) appropriate purified water is added in D-sorbite, is heated to 100 DEG C, dissolves 4min, be cooled to after filtering 30 DEG C it is spare；
(3) slot is added in peppermint dry powder, collagen, amino acid, small molecule Gly-His-Lys, vitamin A, vitamin B and vitamin E
Formula mixing machine mixing 30min, obtains mixture；
(4) it will be put into blender, be stirred continuously, and egg white lysozyme dry powder is added obtained by step (2) and step (3)
And papain, it is dried after mixing to it, dry environment temperature is 35 DEG C, and drying to weight moisture content is not more than
The 5% of total weight；
(5) raw material after drying is carried out by tabletting by tablet press machine, and is sealed and is packed with food bag, obtain finished product.
Embodiment 2
It is a kind of quickly to eliminate bad breath the sugar-free hard candy piece for removing helicobacter pylori, the raw material including following parts by weight:
25 parts of peppermint dry powder；60 parts of D-sorbite；7 parts of egg white lysozyme dry powder；1 part of papain；8 parts of collagen；Amino
7 parts of acid；8 parts of small molecule Gly-His-Lys；0.06 part of vitamin A；0.06 part and 0.06 part of vitamin E of vitamin B.
The peppermint dry powder is filtering of squeezing the juice after cleaning up fresh mint, and filtrate is cold at -10 DEG C~-25 DEG C
Freeze vacuum drying to get peppermint dry powder is arrived；The amino acid is glutamic acid and arginic mixture；The vitamin A,
The granularity of vitamin B and vitamin E is 700 mesh.
The preparation method of the egg white lysozyme dry powder includes the following steps:
1. taking egg white, clean, the water of 2.3 times of egg white volume amounts is added in egg white, stirs evenly, is heated to 60 DEG C, heat preservation
Reaction 4 minutes, is filtered to remove foreign protein,
2. cleaner liquid NaC03It is 8 that solution, which is adjusted to pH value, and the acrylic acid of egg white quality 0.15% is added, and it is small that 24 are precipitated at 4 DEG C
When, filtering；
3. the hydrochloric acid solution that 10.5 times of Sediment weight amount pH values are 6 is added in obtained precipitating to dissolve, and CaCl is added2Gu
Body, CaCl2The amount of addition is consistent with the step amount that 2. middle acrylic acid is added；After reaction 1.5 hours, filtering；
4. obtained filtrate is through 0.22 micron of membrane filtration, then the ultrafiltration concentration centrifuge tube for being 5K through molecular cut off, ultrafiltration
Concentration；
5. in concentrate be added volumetric concentration be 95% ethyl alcohol, until in concentrate ethyl alcohol volume content be 73%, then in-
It is precipitated 24 hours at 5 DEG C~-6 DEG C；
6. being deposited at -10 DEG C for obtaining is carried out vacuum freeze drying, the chicken that enzymatic activity recovery is 80-90% can be prepared by
Egg white lysozyme dry powder.
Described quickly eliminates bad breath the sugar-free hard candy piece for removing helicobacter pylori, and preparation method includes the following steps:
(1) various raw material for standby are taken in parts by weight；
(2) appropriate purified water is added in D-sorbite, is heated to 100 DEG C, dissolves 5min, be cooled to after filtering 35 DEG C it is spare；
(3) slot is added in peppermint dry powder, collagen, amino acid, small molecule Gly-His-Lys, vitamin A, vitamin B and vitamin E
Formula mixing machine mixing 35min, obtains mixture；
(4) it will be put into blender, be stirred continuously, and egg white lysozyme dry powder is added obtained by step (2) and step (3)
And papain, it is dried after mixing to it, dry environment temperature is 40 DEG C, and drying to weight moisture content is not more than
The 5% of total weight；
(5) raw material after drying is carried out by tabletting by tablet press machine, and is sealed and is packed with food bag, obtain finished product.
Embodiment 3
It is a kind of quickly to eliminate bad breath the sugar-free hard candy piece for removing helicobacter pylori, the raw material including following parts by weight:
30 parts of peppermint dry powder；65 parts of D-sorbite；10 parts of egg white lysozyme dry powder；1.5 parts of papain；10 parts of collagen；
0 part of amino acid 1；10 parts of small molecule Gly-His-Lys；0.07 part of vitamin A；0.07 part and 0.07 part of vitamin E of vitamin B.
The peppermint dry powder is filtering of squeezing the juice after cleaning up fresh mint, and filtrate is cold at -10 DEG C~-25 DEG C
Freeze vacuum drying to get peppermint dry powder is arrived；The amino acid is the mixing of aspartic acid, glutamic acid and arginine three
Object；The granularity of the vitamin A, vitamin B and vitamin E is 800 mesh.
The preparation method of the egg white lysozyme dry powder includes the following steps:
1. taking egg white, clean, the water of 2.5 times of egg white volume amounts is added in egg white, stirs evenly, is heated to 60 DEG C, heat preservation
Reaction 5 minutes, is filtered to remove foreign protein,
2. cleaner liquid NaC03It is 8 that solution, which is adjusted to pH value, and the acrylic acid of egg white quality 0.22% is added, and it is small that 22 are precipitated at 5 DEG C
When, filtering；
3. the hydrochloric acid solution that 11 times of Sediment weight amount pH values are 6 is added in obtained precipitating to dissolve, and CaCl is added2Solid,
CaCl2The amount of addition is consistent with the step amount that 2. middle acrylic acid is added；After reaction 2 hours, filtering；
4. obtained filtrate is through 0.22 micron of membrane filtration, then the ultrafiltration concentration centrifuge tube for being 5K through molecular cut off, ultrafiltration
Concentration；
5. in concentrate be added volumetric concentration be 95% ethyl alcohol, until in concentrate ethyl alcohol volume content be 75%, then in-
It is precipitated 24 hours at 6 DEG C；
6. being deposited at -10 DEG C for obtaining is carried out vacuum freeze drying, the chicken that enzymatic activity recovery is 80-90% can be prepared by
Egg white lysozyme dry powder.
Described quickly eliminates bad breath the sugar-free hard candy piece for removing helicobacter pylori, and preparation method includes the following steps:
(1) various raw material for standby are taken in parts by weight；
(2) appropriate purified water is added in D-sorbite, is heated to 100 DEG C, dissolves 6min, be cooled to after filtering 40 DEG C it is spare；
(3) slot is added in peppermint dry powder, collagen, amino acid, small molecule Gly-His-Lys, vitamin A, vitamin B and vitamin E
Formula mixing machine mixing 40min, obtains mixture；
(4) it will be put into blender, be stirred continuously, and egg white lysozyme dry powder is added obtained by step (2) and step (3)
And papain, it is dried after mixing to it, dry environment temperature is 45 DEG C, and drying to weight moisture content is not more than
The 5% of total weight；
(5) raw material after drying is carried out by tabletting by tablet press machine, and is sealed and is packed with food bag, obtain finished product.
Effect test
(1) by the embodiment of the present invention 2 be prepared quickly eliminate bad breath remove helicobacter pylori sugar-free hard candy piece finished product according to
Common candy product inspection regulation is examined outer, has also investigated manufactured sugar-free hard candy piece to saprodontia, the inhibitory effect of plaque, into
Row helicobacter pylori turns sugar chain coccus (Streptococcus mutans), micrococcus scarlatinae
(Streptococcussobrinus), porphyromonas gingivalis (Porphyromonas gingivalis, P.gingivalis)
Inhibit the detection of effect.
The result shows that quickly eliminating bad breath the sugar-free hard candy piece for removing helicobacter pylori made of embodiment 2 to pylorus spiral shell
The inhibiting rate of spinner handle bacterium is 99 .99%, and the streptococcic inhibiting rate of sugar that turns to dental decayed tooth is 99 .98% and suppurative chain
The inhibiting rate of coccus is 99 .98%, and the inhibiting rate to porphyromonas gingivalis is 99 .98%.
These above-mentioned Oral Bacterias can cause a variety of diseases such as plaque, periodontitis, parulis, sphagitis, tonsillitis.
Test result confirms that the sugar-free hard candy piece for removing helicobacter pylori is quickly eliminated bad breath made of embodiment 2 has stronger sterilization
Effect, can kill the bacterium for leading to saprodontia, halitosis, periodontitis in oral cavity, have good elimination halitosis, inhibit saprodontia, tooth bacterium
The effect of spot and parulis, has certain protective effect to children caries, the hair of saprodontia is reduced while eating candy
Raw rate.
(2) city sugar-free hard candy Pian He for removing helicobacter pylori is quickly eliminated bad breath made of 2 through the embodiment of the present invention
Sugar-free hard candy on face is compared, and is done further to the sugar-free hard candy piece of the invention for quickly eliminating bad breath removing helicobacter pylori
Illustrate, different candy power test test scores results are as shown in table 1 below:
It is above-mentioned as it can be seen that the present invention be prepared quickly eliminate bad breath remove helicobacter pylori sugar-free hard candy piece smell persistence
It is good, and have and eliminate bad breath effect well.
Claims (6)
1. a kind of quickly eliminate bad breath the sugar-free hard candy piece for removing helicobacter pylori, which is characterized in that including following parts by weight
Raw material:
20-30 parts of peppermint dry powder；55-65 parts of D-sorbite；5-10 parts of egg white lysozyme dry powder；0.2-1.5 parts of papain；Glue
Former albumen 5-10 parts；5-10 parts of amino acid；5-10 parts of small molecule Gly-His-Lys；0.05-0.07 parts of vitamin A；Vitamin B 0.05-
0.07 part and vitamin E 0.05-0.07 parts.
2. according to claim 1 quickly eliminate bad breath the sugar-free hard candy piece for removing helicobacter pylori, which is characterized in that institute
The peppermint dry powder stated is filtering of squeezing the juice after cleaning up fresh mint, and by filtrate, freezing vacuum is done at -10 DEG C~-25 DEG C
It is dry to get arrive peppermint dry powder.
3. according to claim 1 quickly eliminate bad breath the sugar-free hard candy piece for removing helicobacter pylori, which is characterized in that institute
The amino acid stated includes one of aspartic acid, glutamic acid and arginine or a variety of.
4. according to claim 1 quickly eliminate bad breath the sugar-free hard candy piece for removing helicobacter pylori, which is characterized in that institute
The granularity of vitamin A, vitamin B and the vitamin E stated is 500~800 mesh.
5. according to claim 1 quickly eliminate bad breath the sugar-free hard candy piece for removing helicobacter pylori, which is characterized in that institute
The preparation method for the egg white lysozyme dry powder stated includes the following steps:
1. taking egg white, clean, the water of 2~2.5 times of egg white volume amounts is added in egg white, stirs evenly, be heated to 60 DEG C, protects
Temperature reaction 3~5 minutes, is filtered to remove foreign protein,
2. cleaner liquid NaC03It is 8 that solution, which is adjusted to pH value, the acrylic acid of egg white quality 0.12~0.22% is added, in 3 DEG C~5 DEG C
Lower precipitating 22~25 hours, filtering；
3. the hydrochloric acid solution that 10~11 times of Sediment weight amount pH values are 6 is added in obtained precipitating to dissolve, and CaCl is added2,
CaCl2The amount of addition is consistent with the step amount that 2. middle acrylic acid is added；After reaction 1-2 hours, filtering；
4. obtained filtrate is through 0.22 micron of membrane filtration, then the ultrafiltration concentration centrifuge tube for being 5K through molecular cut off, ultrafiltration
Concentration；
5. the ethyl alcohol that volumetric concentration is 95% is added in concentrate, until the volume content of ethyl alcohol is 72%-75% in concentrate, so
It is precipitated 24 hours at -5 DEG C~-6 DEG C afterwards；
6. being deposited at -10 DEG C for obtaining is carried out vacuum freeze drying, the chicken that enzymatic activity recovery is 80-90% can be prepared by
Egg white lysozyme dry powder.
6. according to claim 1 quickly eliminate bad breath the sugar-free hard candy piece for removing helicobacter pylori, which is characterized in that its
Preparation method the following steps are included:
(1) various raw material for standby are taken in parts by weight；
(2) appropriate purified water is added in D-sorbite, is heated to 100 DEG C, dissolves 4~6min, is cooled to 30-40 DEG C after filtering
It is spare；
(3) slot is added in peppermint dry powder, collagen, amino acid, small molecule Gly-His-Lys, vitamin A, vitamin B and vitamin E
Formula mixing machine mixing 30-40min, obtains mixture；
(4) it will be put into blender, be stirred continuously, and egg white lysozyme dry powder is added obtained by step (2) and step (3)
And papain, it is dried after mixing to it, dry environment temperature is 35~45 DEG C, is dried to weight moisture content not
Greater than the 5% of total weight；
(5) raw material after drying is carried out by tabletting by tablet press machine, and is sealed and is packed with food bag, obtain finished product.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110538318A (en) * | 2019-09-27 | 2019-12-06 | 中合泰克(南京)生物科技有限公司 | Spray for preventing and controlling oral helicobacter pylori and preparation method thereof |
| CN110651875A (en) * | 2019-09-27 | 2020-01-07 | 中合泰克(南京)生物科技有限公司 | Ring candy for preventing and controlling helicobacter pylori and preparation method thereof |
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| CN103272224A (en) * | 2013-06-26 | 2013-09-04 | 乔敏 | Lysozyme sugar lozenge and preparation method thereof |
| CN103749917A (en) * | 2013-12-26 | 2014-04-30 | 深圳市聚特佳生物科技有限公司 | Low-sugar mint tabletted candy and preparation method thereof |
| CN107712245A (en) * | 2017-11-22 | 2018-02-23 | 东莞亿智食品有限公司 | A kind of low sugar health care candy and preparation method thereof |
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| CN110538318A (en) * | 2019-09-27 | 2019-12-06 | 中合泰克(南京)生物科技有限公司 | Spray for preventing and controlling oral helicobacter pylori and preparation method thereof |
| CN110651875A (en) * | 2019-09-27 | 2020-01-07 | 中合泰克(南京)生物科技有限公司 | Ring candy for preventing and controlling helicobacter pylori and preparation method thereof |
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Application publication date: 20190416 |