CN110237024A - A kind of whitening probiotics toothpaste and preparation method thereof - Google Patents
A kind of whitening probiotics toothpaste and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to technical field of daily necessities, and in particular to a kind of whitening probiotics toothpaste and preparation method thereof.Whitening probiotics toothpaste provided by the invention includes following component and its weight percent: Chinese wistaria extracting solution 0.1~0.3%, edible essence 1~2%, Bacillus acidi lactici 1~2%, spend 0.08~0.15% in Milan, rubbing agent 10~15%, surfactant 3~6%, sodium phytate 0.5~1%, cellulose gum 1~3%, tetrasodium pyrophosphate 0.2~0.3%, sodium benzoate 0.08~0.10%, moisturizer 43~60%, titanium dioxide 0.05~0.10%, saccharin sodium 0.03~0.04%, benzyl alcohol 0.02~0.03%, water 9.98~39.94%.Whitening probiotics toothpaste provided by the invention can maintain colony balance in oral cavity, stimulate body immune system, improve the immunocompetence of body.
Description
Technical field
The invention belongs to technical field of daily necessities, and in particular to a kind of whitening probiotics toothpaste and preparation method thereof.
Background technique
Toothpaste is necessary cleaning supplies in daily life, with the continuous promotion of the production technology of toothpaste, and masses
Improvement of living standard, the demand to toothpaste have been not limited to single cleaning tooth, the female to like to be beautiful for most of youth
Property, then more tend to the whitening and nursing to tooth.
Modern medicine thinks that 80% halitosis is to decompose the swill in teeth space by intraoral anaerobic bacteria excessive multiplication
And the volatile sulfur compounds released.And probiotics is then that one kind has bacteriostasis, and the microorganism beneficial to human body.It is this
Microorganism can directly treat the root of halitosis directly against the root problem of oral cavity halitosis problem.Most of benefit at present
Raw bacterium enters human body in the form of food drink etc., mainly for the effect to enteron aisle, does not play a role in oral cavity.
Chinese patent application CN107854374 A discloses a kind of antibacterial whitening toothpaste, and the antibacterial whitening toothpaste includes
Acrylic acid polymer, Flos Camelliae Japonicae extract, bamboo charcoal, moisturizer, thickener etc., although the toothpaste can effectively drive away tooth dirt
Dirt can be produced into avoid because of bleeding gums phenomenon caused by rubbing moreover, because being not added with new hemostatic compositions and reducing
This, still, which is easy to appear the problem of harmful bacteria pollutes, and oral cavity is caused to be polluted.
Chinese patent application CN108743419 A discloses a kind of antibacterial except stain toothpaste, and the antibacterial includes except stain toothpaste
Copper carbon composite, zeolite and silica, the toothpaste have broad-spectrum antiseptic, safely, have no stimulation, can be with deep clean mouth
Chamber, effectively removing plaque, remove stain brilliant white, still, which can also inhibit the growth of some beneficial bacteriums, moreover, this toothpaste
It is also easy to cause bacterium infection, reduces body immunity.
To sum up, in the prior art about the product of antibacterial toothpaste it is generally existing be easy to cause oral cavity pollution, reduce human body exempt from
Epidemic disease power, disadvantage at high cost.
Summary of the invention
In order to overcome disadvantage existing in the prior art, the purpose of the present invention is to provide a kind of whitening probiotics toothpaste and
Preparation method.Whitening probiotics toothpaste provided by the invention is added to Bacillus acidi lactici, using toothpaste as carrier, realizes to human body
The inhibition of pernicious bacteria in oral cavity, maintains the balance of microorganism in oral cavity, greatly improves the immunity of human body.
In order to achieve the above object, the technical solution adopted by the present invention are as follows:
A kind of whitening probiotics toothpaste, including following component and its weight percent: Chinese wistaria extracting solution 0.1~0.3%, food
With essence 1~2%, Bacillus acidi lactici 1~2%, Milan spends 0.08~0.15%, rubbing agent 10~15%, and surfactant 3~
6%, sodium phytate 0.5~1%, cellulose gum 1~3%, tetrasodium pyrophosphate 0.2~0.3%, sodium benzoate 0.08~0.10%,
Moisturizer 43~60%, titanium dioxide 0.05~0.10%, saccharin sodium 0.03~0.04%, benzyl alcohol 0.02~0.03%, water
9.98~39.94%.
Further, the whitening probiotics toothpaste, is made of following component and its weight percent: Chinese wistaria extracting solution
0.2%, edible essence 1.5%, Bacillus acidi lactici 1.5%, Milan spends 0.11%, and rubbing agent 13%, surfactant 4.5% is planted
Sour sodium 0.8%, cellulose gum 2%, tetrasodium pyrophosphate 0.25%, sodium benzoate 0.09%, moisturizer 52%, titanium dioxide
0.08%, saccharin sodium 0.03%, benzyl alcohol 0.03%, water 24.22%.
Further, the rubbing agent is hydrated silica.
Further, the moisturizer by D-sorbite, glycerol and polyethylene glycol-8 30~40:5 by weight percentage~
8:8~12 is formed；The surfactant by Cocoamidopropyl betaine and sodium lauroyl sarcosine by weight percentage 2~
4:1~2 is formed.
Further, the moisturizer is by D-sorbite, glycerol and polyethylene glycol-8 35:7:10 group by weight percentage
At；The surfactant is made of Cocoamidopropyl betaine and sodium lauroyl sarcosine 3:1.5 by weight percentage.
The present invention also provides the preparation method of the whitening probiotics, operating procedure is as follows:
S1, Chinese wistaria extracting solution, Bacillus acidi lactici, Milan flower, sodium phytate, moisturizer, surfactant, saccharin sodium and water are mixed
It closes, stirs 15-30min under certain condition, obtain mixture I；
S2, cellulose gum, tetrasodium pyrophosphate, sodium benzoate, rubbing agent, benzene are added into the resulting mixture I of step S1
Methanol, titanium dioxide stir 20-30min under certain condition, grind to obtain mixtures II；
S3, edible essence is added into mixtures II obtained by step S2, stirs under certain condition, grind, then through true
Sky degassing to get.
Further, the certain condition in the step S1 is 25-30 DEG C of temperature, revolving speed 200-300r/min.
Further, the certain condition in the step S2 is 25-28 DEG C of temperature, revolving speed 300-500r/min.
Further, the certain condition in the step S3 is 23-28 DEG C of temperature, revolving speed 200-300r/min.
In the present invention, the sodium phytate of addition is a kind of important fully natural green additive, not only as beauty in toothpaste
White main composition is more widely used in the anti-oxidant and color stabilizer of fruit-vegetable juice beverage, meat products, marine product, more with gold
Belonging to ion has extremely strong chelation.
Chinese wistaria belongs to fallen leaves and climbs up by holding on to the big liana of prehensile, generally obtains associated extraction liquid using enzymatic isolation method, and Chinese wistaria mentions
It takes and contains flavones in liquid, flavones has good antioxidant activity, can effectively remove free radical；Milan flower, belongs to evergreen filling
Wood or dungarunga have the head that wakes up, the only effect of polydipsia.The present invention is found surprisingly that both material mixings use, Ke Yixian
The whitening effect for improving toothpaste is write, facilitates tooth and maintains whitening effect.
Probiotics refers in human body intestinal canal, reproductive system, capable of generating definite health efficacy so as to improve host's Tiny ecosystem
Balance, the active beneficial microorganism general name for playing beneficial effect.And in numerous beneficial microbes, Bacillus acidi lactici is even more to lead
The profitable strain wanted.For current scientific basis, physiological function known to Bacillus acidi lactici is mainly shown as: preventing pathogen
Invasion and field planting inhibit pathogen, anti-infective, maintain microecological balance, prevention and the generation for inhibiting tumour, enhance immunity of organism
Power, synthesizing amino acid and vitamin reduce cholesterol, inhibit endotoxic production, delay senescence and anti-radiation etc..A host of facts
It proves, the quantity of Bacillus acidi lactici increases, and fauna is balanced, so that it may promote body health and treat certain disease.
Compared with prior art, whitening probiotics toothpaste produced by the present invention has the advantage that
(1) whitening probiotics toothpaste provided by the invention, while it being added to pure natural green additive sodium phytate, it is prebiotic
Bacterium Bacillus acidi lactici, both substances mutually cooperate with, to reach effective cleaning to tooth stain, whitening effect is significant, and are mouth
Intracavitary offer profitable strain has the function that inhibit pernicious bacteria, maintains mouth by competing with one another for intraoral pernicious bacteria
Intracavitary colony balance stimulates body immune system, improves the immunocompetence of body；
(2) whitening probiotics toothpaste provided by the invention selects first vector of the toothpaste as probiotics, and in crowd one
In its oral cleaning twice, probiotics is played in intraoral effect, reaches the treatment to oral problem；
(3) whitening probiotics toothpaste provided by the invention, selected moisturizer and surfactant are by plurality of raw materials
It mixing, moistening effect is splendid, moreover, selected raw material is raw material common in the market, and it is cheap, it significantly reduces
The production cost of whitening probiotics toothpaste of the present invention.
Specific embodiment
The present invention is further explained combined with specific embodiments below, it is noted that following embodiment is only
To explain the present invention, and it cannot be used to limit the present invention, all technical solutions same or similar with the present invention are in this hair
Within bright protection scope.Unless otherwise specified, what technological means used in embodiment was well known to those skilled in the art
Conventional means, raw materials used is commercial goods.
A kind of whitening probiotics toothpaste of embodiment 1
The whitening probiotics toothpaste, is made of following component and its weight percent: Chinese wistaria extracting solution 0.1%, eats
Essence 1%, Bacillus acidi lactici 1%, Milan spend 0.08%, rubbing agent 10%, surfactant 3%, sodium phytate 0.5%, cellulose
Glue 1%, tetrasodium pyrophosphate 0.2%, sodium benzoate 0.08%, moisturizer 43%, titanium dioxide 0.05%, saccharin sodium 0.03%,
Benzyl alcohol 0.02%, water 39.94%；The moisturizer is by D-sorbite, glycerol and polyethylene glycol-8 30:5 by weight percentage:
8 compositions；The surfactant is made of Cocoamidopropyl betaine and sodium lauroyl sarcosine 2:1 by weight percentage.
The whitening probiotics toothpaste the preparation method comprises the following steps:
S1, Chinese wistaria extracting solution, Bacillus acidi lactici, Milan flower, sodium phytate, moisturizer, surfactant, saccharin sodium and water are mixed
It closes, 25 DEG C of Yu Wendu, stirs 15min under conditions of revolving speed 200r/min, obtain mixture I；
S2, cellulose gum, tetrasodium pyrophosphate, sodium benzoate, rubbing agent, benzene are added into the resulting mixture I of step S1
Methanol, titanium dioxide, stir 20-30min under conditions of revolving speed 300r/min, grind to obtain mixtures II by 25 DEG C of Yu Wendu；
S3, edible essence is added into mixtures II obtained by step S2, is stirred under 23 DEG C of temperature, revolving speed 200r/min,
Grinding, then through vacuum outgas to get.
A kind of whitening probiotics toothpaste of embodiment 2
The whitening probiotics toothpaste, is made of following component and its weight percent: Chinese wistaria extracting solution 0.3%, eats
Essence 2%, Bacillus acidi lactici 2%, Milan spend 0.15%, rubbing agent 15%, surfactant 6%, sodium phytate 1%, cellulose gum
3%, tetrasodium pyrophosphate 0.3%, sodium benzoate 0.10%, moisturizer 60%, titanium dioxide 0.10%, saccharin sodium 0.04%, benzene
Methanol 0.03%, water 9.98%；The moisturizer is by D-sorbite, glycerol and polyethylene glycol-8 40:8:12 by weight percentage
Composition；The surfactant is made of Cocoamidopropyl betaine and sodium lauroyl sarcosine 4:2 by weight percentage.
The whitening probiotics toothpaste the preparation method comprises the following steps:
S1, Chinese wistaria extracting solution, Bacillus acidi lactici, Milan flower, sodium phytate, moisturizer, surfactant, saccharin sodium and water are mixed
It closes, 30 DEG C of Yu Wendu, stirs 30min under conditions of revolving speed 300r/min, obtain mixture I；
S2, cellulose gum, tetrasodium pyrophosphate, sodium benzoate, rubbing agent, benzene are added into the resulting mixture I of step S1
Methanol, titanium dioxide, stir 30min under conditions of revolving speed 500r/min, grind to obtain mixtures II by 28 DEG C of Yu Wendu；
S3, edible essence is added into mixtures II obtained by step S2, is stirred under 28 DEG C of temperature, revolving speed 300r/min,
Grinding, then through vacuum outgas to get.
A kind of whitening probiotics toothpaste of embodiment 3
The whitening probiotics toothpaste, is made of following component and its weight percent: Chinese wistaria extracting solution 0.2%, eats
Essence 1.5%, Bacillus acidi lactici 1.5%, Milan spend 0.12%, rubbing agent 13%, surfactant 4.5%, sodium phytate 0.8%,
Cellulose gum 2%, tetrasodium pyrophosphate 0.25%, sodium benzoate 0.09%, moisturizer 52%, titanium dioxide 0.08%, saccharin sodium
0.04%, benzyl alcohol 0.02%, water 23.9%；The moisturizer is by D-sorbite, glycerol and polyethylene glycol-8 percentage by weight
It is formed than 35:7:10；The surfactant by Cocoamidopropyl betaine and sodium lauroyl sarcosine by weight percentage
3:1.5 composition.
The whitening probiotics toothpaste the preparation method comprises the following steps:
S1, Chinese wistaria extracting solution, Bacillus acidi lactici, Milan flower, sodium phytate, moisturizer, surfactant, saccharin sodium and water are mixed
It closes, 27 DEG C of Yu Wendu, stirs 23min under conditions of revolving speed 250r/min, obtain mixture I；
S2, cellulose gum, tetrasodium pyrophosphate, sodium benzoate, rubbing agent, benzene are added into the resulting mixture I of step S1
Methanol, titanium dioxide, stir 25min under conditions of revolving speed 400r/min, grind to obtain mixtures II by 26 DEG C of Yu Wendu；
S3, edible essence is added into mixtures II obtained by step S2, is stirred under 25 DEG C of temperature, revolving speed 250r/min,
Grinding, then through vacuum outgas to get.
A kind of toothpaste of comparative example 1
The toothpaste is made of following component and its weight percent: Chinese wistaria extracting solution 0.2%, edible essence 1.5%,
Milan spends 0.12%, rubbing agent 13%, surfactant 4.5%, sodium phytate 0.8%, cellulose gum 2%, tetrasodium pyrophosphate
0.25%, sodium benzoate 0.09%, moisturizer 52%, titanium dioxide 0.08%, saccharin sodium 0.04%, benzyl alcohol 0.02%, water
25.4%；The moisturizer is made of D-sorbite, glycerol and polyethylene glycol-8 35:7:10 by weight percentage；The surface
Activating agent is made of Cocoamidopropyl betaine and sodium lauroyl sarcosine 3:1.5 by weight percentage.
The preparation method of the toothpaste is similar to Example 3；
Difference with embodiment 3 is, Bacillus acidi lactici is not included in comparative example 1.
A kind of toothpaste of comparative example 2
The toothpaste is made of following component and its weight percent: Chinese wistaria extracting solution 0.2%, edible essence 1.5%,
Bacillus acidi lactici 1.5%, Milan spend 0.12%, rubbing agent 13%, surfactant 4.5%, sodium phytate 0.8%, cellulose gum
2%, tetrasodium pyrophosphate 0.25%, sodium benzoate 0.09%, moisturizer 52%, titanium dioxide 0.08%, saccharin sodium 0.04%, benzene
Methanol 0.02%, water 23.9%；The moisturizer is by D-sorbite, glycerol and polyethylene glycol-8 35:7:10 by weight percentage
Composition；The surfactant is made of Cocoamidopropyl betaine and sodium lauroyl sarcosine 1:1 by weight percentage.
The preparation method of the toothpaste is similar to Example 3；
Difference with embodiment 3 is that the surfactant in comparative example 2 is by Cocoamidopropyl betaine and lauroyl
Sodium sarcosinate 1:1 by weight percentage composition.
A kind of toothpaste of comparative example 3
The toothpaste is made of following component and its weight percent: edible essence 1.5%, Bacillus acidi lactici 1.5%, rice
Orchid 0.12%, rubbing agent 13%, surfactant 4.5%, sodium phytate 0.8%, cellulose gum 2%, tetrasodium pyrophosphate
0.25%, sodium benzoate 0.09%, moisturizer 52%, titanium dioxide 0.08%, saccharin sodium 0.04%, benzyl alcohol 0.02%, water
23.9%；The moisturizer is made of D-sorbite, glycerol and polyethylene glycol-8 35:7:10 by weight percentage；The surface
Activating agent is made of Cocoamidopropyl betaine and sodium lauroyl sarcosine 3:1.5 by weight percentage.
The preparation method of the toothpaste is similar to Example 3；
Difference with embodiment 3 is, Chinese wistaria extracting solution is not included in comparative example 3.
A kind of toothpaste of comparative example 4
The toothpaste is made of following component and its weight percent: Chinese wistaria extracting solution 0.2%, edible essence 1.5%,
Bacillus acidi lactici 1.5%, Milan spend 0.12%, rubbing agent 13%, surfactant 4.5%, sodium phytate 0.8%, cellulose gum
2%, tetrasodium pyrophosphate 0.25%, sodium benzoate 0.09%, moisturizer 52%, titanium dioxide 0.08%, saccharin sodium 0.04%, benzene
Methanol 0.02%, water 23.9%；The moisturizer is by D-sorbite, glycerol and polyethylene glycol-8 1:1:1 group by weight percentage
At；The surfactant is made of Cocoamidopropyl betaine and sodium lauroyl sarcosine 3:1.5 by weight percentage.
The preparation method of the toothpaste is similar to Example 3；
Difference with embodiment 3 is that the moisturizer in comparative example 4 is by D-sorbite, glycerol and polyethylene glycol-8 by weight
Measure percentage 1:1:1 composition.
The test of 1 antibacterial effect of test example
1. test specimen: toothpaste made from embodiment 1-3 and comparative example 1-2；
2. subjects: Streptococcus mutans, golden yellow grape autumn bacterium, Escherichia coli；
3. test method: the reference culture for freeze-drying of recovering is inoculated in ordinary flat, cultivates in 37 DEG C of constant incubator
24 hours, bacterium corrected concentrations 10 are taken out after culture8The bacterium solution that 0.1mL has been got ready, embodiment is added in CFU/mL in culture plate
The toothpaste of 1-3 and comparative example 1-2 preparation is diluted with distilled water respectively, and being prepared into concentration is 0.5g/L, the test fluid of 1g/L.
1mL test fluid is taken to be added in the cultivation plate hole containing bacterium solution, to add physiological saline as negative control pipe merely, bacterium solution adds physiology salt
Water is as positive control.Each test tube is put into 37 DEG C of incubator and is cultivated 24 hours.
If become turbid in test tube, show there is bacterium growth, test fluid is without bacteriostasis；If test tube is clarified, then show sterile
Growth, test fluid have bacteriostasis.
3. test result: specific test result is shown in Table 1.
The antibacterial result of 1 different tests sample of table
As shown in Table 1, compared with the control group, the toothpaste of 1-3 of embodiment of the present invention preparation has significant bacteriostasis, can
To inhibit bacterial growth, and various harmful bacterias are caused to grow, comparative example 2 changes due to eliminating Bacillus acidi lactici in comparative example 1
The ratio of surfactant causes a small amount of germ to occur.
The test of 2 whitening effect of test example
1. test specimen: whitening probiotics toothpaste made from embodiment 1-3 and comparative example 3-4；
2. the process of test:
2.1 subjects: the volunteer that 150 the ranges of age have exogenous color spot in 30-50 years old tooth is chosen, at random
It is divided into 5 groups, every group of 30 people；
2.2 test methods: being given the same soft bristle tooth brush of all volunteers, brushed teeth respectively using test specimen, early, evening
Each brush is primary, and brush teeth 1min every time, and requires other oral sanitary habits of subject's holding usually, diet and smoking etc.
Habit.Clinical examination was carried out in baseline, the 4th week and the 8th week, and was completed by the same examiner.Data are united using t inspection
Meter analysis, two-sided test, inspection level α are 0.05, and the results are shown in Table 2.
2.3 evaluation methods: teeth stains are evaluated using Lobene color spot index, evaluate color spot with 0~3 number
The size and color spot degree at position.
The classification score of Lobene color spot index:
0: no color spot exists；
1: color spot is no more than the 1/3 of facing, slight color spot (yellow or yellowish-brown)；
2: color spot is no more than the 2/3 of facing, moderate color spot (moderate brown)；
3: color spot is greater than the 2/3 of facing, severe color spot (dark-brown or black).
3. test result: specific test result is shown in Table 2.
The whitening effect of 2 different tests sample of table
As shown in Table 2, toothpaste made from 1-3 of the embodiment of the present invention has significant tooth-whitening effect, especially to implement
The whitening effect of example 3 is best, and therefore, embodiment 3 is highly preferred embodiment of the present invention.And comparative example 3 eliminates Chinese wistaria extracting solution,
Whitening effect is caused to significantly reduce, comparative example 4 changes the ratio of moisturizer, and whitening effect is also significantly lower than embodiment 1-3 group
Toothpaste.
Finally it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention
The limitation of range, although elaborating referring to preferred embodiment to the present invention, those skilled in the art should be managed
Solution, can with modification or equivalent replacement of the technical solution of the present invention are made, without departing from technical solution of the present invention essence and
Range.
Claims (9)
1. a kind of whitening probiotics toothpaste, which is characterized in that including following component and its weight percent: Chinese wistaria extracting solution 0.1
~0.3%, edible essence 1~2%, Bacillus acidi lactici 1~2%, Milan spends 0.08~0.15%, rubbing agent 10~15%, surface
Activating agent 3~6%, sodium phytate 0.5~1%, cellulose gum 1~3%, tetrasodium pyrophosphate 0.2~0.3%, sodium benzoate 0.08
~0.10%, moisturizer 43~60%, titanium dioxide 0.05~0.10%, saccharin sodium 0.03~0.04%, benzyl alcohol 0.02~
0.03%, water 9.98~39.94%.
2. whitening probiotics toothpaste as described in claim 1, which is characterized in that by following component and its weight percent array
At: Chinese wistaria extracting solution 0.2%, edible essence 1.5%, Bacillus acidi lactici 1.5%, Milan spend 0.11%, and rubbing agent 13%, surface is lived
Property agent 4.5%, sodium phytate 0.8%, cellulose gum 2%, tetrasodium pyrophosphate 0.25%, sodium benzoate 0.09%, moisturizer 52%,
Titanium dioxide 0.08%, saccharin sodium 0.03%, benzyl alcohol 0.03%, water 24.22%.
3. whitening probiotics toothpaste as claimed in claim 1 or 2, which is characterized in that the rubbing agent is hydrated silica.
4. whitening probiotics toothpaste as claimed in claim 1 or 2, which is characterized in that the moisturizer is by D-sorbite, glycerol
And polyethylene glycol-8 30~40:5 by weight percentage~8:8~12 is formed；The surfactant is by cocamidopropyl propyl amide sweet tea
Dish alkali and sodium lauroyl sarcosine 2~4:1 by weight percentage~2 composition.
5. whitening probiotics toothpaste as claimed in claim 4, which is characterized in that the moisturizer by D-sorbite, glycerol and
Polyethylene glycol-8 35:7:10 by weight percentage composition；The surfactant is by Cocoamidopropyl betaine and lauroyl
Sodium sarcosinate 3:1.5 by weight percentage composition.
6. a kind of preparation method of the whitening probiotics as described in claim any one of 1-5, which is characterized in that operating procedure is such as
Under:
S1, Chinese wistaria extracting solution, Bacillus acidi lactici, Milan flower, sodium phytate, moisturizer, surfactant, saccharin sodium and water are mixed,
15-30min is stirred under certain condition, obtains mixture I；
S2, into the resulting mixture I of step S1 be added cellulose gum, tetrasodium pyrophosphate, sodium benzoate, rubbing agent, benzyl alcohol,
Titanium dioxide stirs 20-30min under certain condition, grinds to obtain mixtures II；
S3, edible essence is added into mixtures II obtained by step S2, stirs under certain condition, grind, it is then de- through vacuum
Gas to get.
7. the preparation method of whitening probiotics as claimed in claim 6, which is characterized in that the certain condition in the step S1
It is 25-30 DEG C of temperature, revolving speed 200-300r/min.
8. the preparation method of whitening probiotics as claimed in claim 6, which is characterized in that the certain condition in the step S2
It is 25-28 DEG C of temperature, revolving speed 300-500r/min.
9. the preparation method of whitening probiotics as claimed in claim 6, which is characterized in that the certain condition in the step S3
It is 23-28 DEG C of temperature, revolving speed 200-300r/min.
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| CN111888315A (en) * | 2020-09-10 | 2020-11-06 | 山东钰财农业发展有限公司 | Preparation method of black garlic toothpaste |
| CN112120987A (en) * | 2020-11-01 | 2020-12-25 | 贵州锦黔商贸有限公司 | Roxburgh rose VC toothpaste and preparation method thereof |
| CN116898741A (en) * | 2023-08-18 | 2023-10-20 | 广州品硬生物科技有限公司 | Gum restoration toothpaste containing lysozyme and probiotics and preparation method thereof |
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