CN109330942A - A kind of formulation of tooth-paste containing oral cavity probiotics - Google Patents

A kind of formulation of tooth-paste containing oral cavity probiotics Download PDF

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Publication number
CN109330942A
CN109330942A CN201811401919.6A CN201811401919A CN109330942A CN 109330942 A CN109330942 A CN 109330942A CN 201811401919 A CN201811401919 A CN 201811401919A CN 109330942 A CN109330942 A CN 109330942A
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parts
probiotics
oral cavity
tooth
formulation
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CN201811401919.6A
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Chinese (zh)
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林锡慧
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

The invention discloses a kind of formulation of tooth-paste containing oral cavity probiotics, the raw material including following parts by weight: 100 parts of toothpaste base-material, 0.5~5 part of natural mineral salt, 1~10 part of probiotics and 35~42 parts of Chinese herbal medicine.Toothpaste prepared by the present invention can effectively reduce intraoral bacteria breed by adding probiotics, maintain the oral cavity ecological balance, the probability of plaque is reduced, to reduce the illness rate of periodontosis；It can effectively reduce and prevent user from the phenomenon that allergy occur；The preparation method of toothpaste is simple, can be mass.

Description

A kind of formulation of tooth-paste containing oral cavity probiotics
Technical field
The present invention relates to formulation of tooth-paste technical field more particularly to a kind of formulation of tooth-paste containing oral cavity probiotics.
Background technique
Oral cavity is first of critical point of human health, and human oral cavity environment is the complicated life containing multiple-microorganism State system.The excess growth breeding of some of them microorganism unfavorable to oral health will lead to saprodontia, periodontitis and halitosis Occur.Periodontosis is the disease occurred in tooth surrounding tissue, is broadly divided into gingivitis and periodontitis, wherein gingivitis is mainly broken Bad gingiva tissue, periodontitis lesion mainly invade gum, parodontium, alveolar bone and cementum.Periodontosis can lead to bleeding gums, Halitosis, tooth mobility and displacement etc.；
Therapeutic modality by taking antibiotic can destroy the balance of the oral cavity ecosystem, but therapeutic effect is often not to the utmost such as people Meaning, in addition existing toothpaste influences less, can not fundamentally improve oral environment, thus to the colony balance in maintenance oral cavity We have devised a kind of formulation of tooth-paste containing oral cavity probiotics to solve problem above.
Summary of the invention
The purpose of the present invention is to solve disadvantages existing in the prior art, and the one kind proposed contains oral cavity probiotics Formulation of tooth-paste.
To achieve the goals above, present invention employs following technical solutions:
A kind of formulation of tooth-paste containing oral cavity probiotics, which is characterized in that the raw material including following parts by weight: toothpaste base-material 100 Part, 0.5~5 part of natural mineral salt, 1~10 part of probiotics and 35~42 parts of Chinese herbal medicine.
Preferably, the raw material including following parts by weight: 100 parts of toothpaste base-material, 3 parts of natural mineral salt, 7 parts of probiotics With 40 parts of Chinese herbal medicine.
Preferably, the natural mineral salt is strontium salt and sylvite, and wherein sylvite is potassium chloride, and strontium salt is strontium chloride.
Preferably, the probiotics is Lactobacillus crispatus, lactobacillus fermenti, lactobacillus plantarum, Yue Shi lactobacillus, saliva cream One of bacillus, lactobacillus acidophilus, lactobacillus gasseri or a variety of mixtures.
Preferably, the Chinese herbal medicine includes the raw material of following components: 13~17 parts of honeysuckle, connects 10~15 parts of datura flower Stick up 8~14 parts and 10~15 parts of the root bark of tree peony.
Preferably, the Chinese herbal medicine includes the raw material of following components: 16 parts of honeysuckle, 13 parts of datura flower, 12 parts of Fructus Forsythiae and 13 parts of the root bark of tree peony.
Preferably, toothpaste preparation method the following steps are included:
S1, raw material weigh, and weigh raw material according to weight ratio, including 100 parts of toothpaste base-material, 0.5~5 part of natural mineral salt, 1~10 part and 35~42 parts of Chinese herbal medicine of probiotics；
S2, the pretreatment of Chinese herbal medicine: being stirred mixing for Chinese herbal medicine weighed in S1, ferment, and carries out during filters pressing obtains Decoction；
S3, mixing: will toothpaste base-material weighed in S1 be added blender in, then successively be added natural mineral salt, Chinese medicine juice and Probiotics obtains mixture after mixing evenly；
Fruit storage: S4 carries out vacuumize process to the mixture in S3, then deaerates, obtain lotion, be made after grinding Toothpaste.
Compared with prior art, the beneficial effects of the present invention are:
1, the toothpaste prepared by the present invention can effectively reduce intraoral bacteria breed by adding probiotics, maintain oral cavity raw State balance, reduces the probability of plaque, to reduce the illness rate of periodontosis；
2, toothpaste of the invention is added with sylvite and strontium salt, and strontium salt has the duct of the tubule of closing dentine opening, thus group Knit the effect of prevention is ached, the tubule that the potassium ion in sylvite enters dentine can reduce the permeability of dentine, and with nerve Tip has affinity interaction, improves the transmitting of nerve impulse, while cooperation has effects that the Chinese herbal medicine of antiallergy, can high degree Improve, can effectively reduce and prevent user from the phenomenon that allergy occur.
In conclusion toothpaste prepared by the present invention can significantly reduce the growth of microorganism and bacterium in oral cavity, improve Oral environment improves and prevents the sick rate of periodontosis, and preparation method is simple, can be mass.
Specific embodiment
The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation Example is only a part of the embodiment of the present invention, instead of all the embodiments.
Embodiment one
A kind of formulation of tooth-paste containing oral cavity probiotics, which is characterized in that the raw material including following parts by weight: toothpaste base-material 100 Part, 0.5 part of natural mineral salt, 1 part of probiotics and 35 parts of Chinese herbal medicine, natural mineral salt are strontium salt and sylvite, and wherein sylvite is chlorine Change potassium, strontium salt is strontium chloride, and probiotics is Lactobacillus crispatus, lactobacillus fermenti, lactobacillus plantarum, Yue Shi lactobacillus, saliva cream One of bacillus, lactobacillus acidophilus, lactobacillus gasseri or a variety of mixtures, Chinese herbal medicine include the raw material of following components: gold 13 parts of honeysuckle flower, 10 parts of datura flower, 8 parts of Fructus Forsythiae and 10 parts of the root bark of tree peony.
It is worth noting that the preparation method of toothpaste the following steps are included:
S1, raw material weigh, and weigh raw material according to weight ratio, including 100 parts of toothpaste base-material, 0.5 part of natural mineral salt, prebiotic 1 part and 35 parts of Chinese herbal medicine of bacterium；
S2, the pretreatment of Chinese herbal medicine: being stirred mixing for Chinese herbal medicine weighed in S1, ferment, and carries out during filters pressing obtains Decoction；
S3, mixing: will toothpaste base-material weighed in S1 be added blender in, then successively be added natural mineral salt, Chinese medicine juice and Probiotics obtains mixture after mixing evenly；
Fruit storage: S4 carries out vacuumize process to the mixture in S3, then deaerates, obtain lotion, be made after grinding Toothpaste.
Embodiment two
A kind of formulation of tooth-paste containing oral cavity probiotics, which is characterized in that the raw material including following parts by weight: toothpaste base-material 100 Part, 3 parts of natural mineral salt, 7 parts of probiotics and 40 parts of Chinese herbal medicine, natural mineral salt are strontium salt and sylvite, and wherein sylvite is chlorination Potassium, strontium salt are strontium chloride, and probiotics is Lactobacillus crispatus, lactobacillus fermenti, lactobacillus plantarum, Yue Shi lactobacillus, saliva cream bar One of bacterium, lactobacillus acidophilus, lactobacillus gasseri or a variety of mixtures, Chinese herbal medicine include the raw material of following components: gold and silver Spend 16 parts, 13 parts of datura flower, 12 parts of Fructus Forsythiae and 13 parts of the root bark of tree peony.
It is worth noting that the preparation method of toothpaste the following steps are included:
S1, raw material weigh, and weigh raw material, including 100 parts of toothpaste base-material, 3 parts of natural mineral salt, probiotics according to weight ratio 7 parts and 40 parts of Chinese herbal medicine；
S2, the pretreatment of Chinese herbal medicine: being stirred mixing for Chinese herbal medicine weighed in S1, ferment, and carries out during filters pressing obtains Decoction；
S3, mixing: will toothpaste base-material weighed in S1 be added blender in, then successively be added natural mineral salt, Chinese medicine juice and Probiotics obtains mixture after mixing evenly；
Fruit storage: S4 carries out vacuumize process to the mixture in S3, then deaerates, obtain lotion, be made after grinding Toothpaste.
Embodiment three
A kind of formulation of tooth-paste containing oral cavity probiotics, which is characterized in that the raw material including following parts by weight: toothpaste base-material 100 Part, 5 parts of natural mineral salt, 10 parts of probiotics and 42 parts of Chinese herbal medicine, natural mineral salt are strontium salt and sylvite, and wherein sylvite is chlorination Potassium, strontium salt are strontium chloride, and probiotics is Lactobacillus crispatus, lactobacillus fermenti, lactobacillus plantarum, Yue Shi lactobacillus, saliva cream bar One of bacterium, lactobacillus acidophilus, lactobacillus gasseri or a variety of mixtures, Chinese herbal medicine include the raw material of following components: gold and silver Spend 17 parts, 15 parts of datura flower, 14 parts of Fructus Forsythiae and 15 parts of the root bark of tree peony.
It is worth noting that the preparation method of toothpaste the following steps are included:
S1, raw material weigh, and weigh raw material, including 100 parts of toothpaste base-material, 5 parts of natural mineral salt, probiotics according to weight ratio 10 parts and 42 parts of Chinese herbal medicine；
S2, the pretreatment of Chinese herbal medicine: being stirred mixing for Chinese herbal medicine weighed in S1, ferment, and carries out during filters pressing obtains Decoction；
S3, mixing: will toothpaste base-material weighed in S1 be added blender in, then successively be added natural mineral salt, Chinese medicine juice and Probiotics obtains mixture after mixing evenly；
Fruit storage: S4 carries out vacuumize process to the mixture in S3, then deaerates, obtain lotion, be made after grinding Toothpaste.
The toothpaste of above-mentioned three groups of embodiments preparation is test group, as a control group with the ordinary toothpaste bought in the market, right Four groups are tested with patients with periodontitis, and every group of experiment number is 20 people, at the same take before experiment each experimenter by Examination person aspirates to collect bacterium in tongue back side before experiment, uses blood agar after then diluting the sample gradient of collection Culture medium is cultivated under 37 DEG C of anaerobic condition, and after 72 hours, and unit of account area inner circumferential is with α, γ zone of hemolysis Or the clump count of β zone of hemolysis, improvement statistics was carried out to experimenter in 3 months, and to the clump count at patient's tongue back after 3 months It counts again, obtains following table:
By upper table it is found that toothpaste prepared by the present invention can significantly reduce the growth of microorganism and bacterium in oral cavity, improve Oral environment improves periodontitis.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto, Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.

Claims (7)

1. a kind of formulation of tooth-paste containing oral cavity probiotics, which is characterized in that the raw material including following parts by weight: toothpaste base-material 100 parts, 0.5~5 part of natural mineral salt, 1~10 part of probiotics and 35~42 parts of Chinese herbal medicine.
2. a kind of formulation of tooth-paste containing oral cavity probiotics according to claim 1, which is characterized in that described includes following The raw material of parts by weight: 100 parts of toothpaste base-material, 3 parts of natural mineral salt, 7 parts of probiotics and 40 parts of Chinese herbal medicine.
3. a kind of formulation of tooth-paste containing oral cavity probiotics according to claim 1, which is characterized in that the natural minerals Salt is strontium salt and sylvite, and wherein sylvite is potassium chloride, and strontium salt is strontium chloride.
4. a kind of formulation of tooth-paste containing oral cavity probiotics according to claim 1, which is characterized in that the probiotics is Lactobacillus crispatus, lactobacillus fermenti, lactobacillus plantarum, Yue Shi lactobacillus, Lactobacillus salivarius, lactobacillus acidophilus, lactobacillus gasseri One of or a variety of mixtures.
5. a kind of formulation of tooth-paste containing oral cavity probiotics according to claim 1, which is characterized in that the medium-height grass pack Include the raw material of following components: 13~17 parts of honeysuckle, 10~15 parts of datura flower, 8~14 parts of Fructus Forsythiae and 10~15 parts of the root bark of tree peony.
6. a kind of formulation of tooth-paste containing oral cavity probiotics according to claim 5, which is characterized in that the medium-height grass pack Include the raw material of following components: 16 parts of honeysuckle, 13 parts of datura flower, 12 parts of Fructus Forsythiae and 13 parts of the root bark of tree peony.
7. a kind of formulation of tooth-paste containing oral cavity probiotics according to claim 1, which is characterized in that the preparation side of toothpaste Method the following steps are included:
S1, raw material weigh, and weigh raw material according to weight ratio, including 100 parts of toothpaste base-material, 0.5~5 part of natural mineral salt, 1~10 part and 35~42 parts of Chinese herbal medicine of probiotics；
S2, the pretreatment of Chinese herbal medicine: being stirred mixing for Chinese herbal medicine weighed in S1, ferment, and carries out during filters pressing obtains Decoction；
S3, mixing: will toothpaste base-material weighed in S1 be added blender in, then successively be added natural mineral salt, Chinese medicine juice and Probiotics obtains mixture after mixing evenly；
Fruit storage: S4 carries out vacuumize process to the mixture in S3, then deaerates, obtain lotion, be made after grinding Toothpaste.
CN201811401919.6A 2018-11-22 2018-11-22 A kind of formulation of tooth-paste containing oral cavity probiotics Pending CN109330942A (en)

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Cited By (6)

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Publication number Priority date Publication date Assignee Title
CN110237024A (en) * 2019-07-22 2019-09-17 佛山卡丝生物科技有限公司 A kind of whitening probiotics toothpaste and preparation method thereof
CN111084754A (en) * 2020-02-20 2020-05-01 江苏微康生物科技有限公司 Probiotic toothpaste for resisting oral helicobacter pylori and preparation method thereof
CN113398059A (en) * 2021-07-13 2021-09-17 镇江市天益生物科技有限公司 Toothpaste containing oral probiotics and preparation method thereof
CN113957006A (en) * 2021-09-27 2022-01-21 微康益生菌(苏州)股份有限公司 Lactobacillus plantarum N13 and application thereof in preventing or treating dental caries and periodontitis
CN115068534A (en) * 2022-06-10 2022-09-20 赵蔚萍 Oral traditional Chinese medicine preparation for treating acute periodontitis
CN115606805A (en) * 2022-09-29 2023-01-17 广州能靓生物技术有限公司 Metabiotic composition and application thereof in oral health

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110237024A (en) * 2019-07-22 2019-09-17 佛山卡丝生物科技有限公司 A kind of whitening probiotics toothpaste and preparation method thereof
CN110237024B (en) * 2019-07-22 2022-04-19 佛山卡丝生物科技有限公司 Whitening probiotic toothpaste and preparation method thereof
CN111084754A (en) * 2020-02-20 2020-05-01 江苏微康生物科技有限公司 Probiotic toothpaste for resisting oral helicobacter pylori and preparation method thereof
CN111084754B (en) * 2020-02-20 2022-08-23 江苏微康生物科技有限公司 Probiotic toothpaste for resisting oral helicobacter pylori and preparation method thereof
CN113398059A (en) * 2021-07-13 2021-09-17 镇江市天益生物科技有限公司 Toothpaste containing oral probiotics and preparation method thereof
CN113957006A (en) * 2021-09-27 2022-01-21 微康益生菌(苏州)股份有限公司 Lactobacillus plantarum N13 and application thereof in preventing or treating dental caries and periodontitis
CN113957006B (en) * 2021-09-27 2022-09-30 微康益生菌(苏州)股份有限公司 Lactobacillus plantarum N13 and application thereof in preventing or treating dental caries and periodontitis
CN115068534A (en) * 2022-06-10 2022-09-20 赵蔚萍 Oral traditional Chinese medicine preparation for treating acute periodontitis
CN115606805A (en) * 2022-09-29 2023-01-17 广州能靓生物技术有限公司 Metabiotic composition and application thereof in oral health

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