CN106581060A - Reinforcing type gingiva repairing and oral cavity care composition and application thereof - Google Patents
Reinforcing type gingiva repairing and oral cavity care composition and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention relates to a reinforcing type gingiva repairing and oral cavity care composition and an application thereof. Active components of the composition include bioactive mineral powder and polylysine. The composition has the comprehensive effects of treating oral diseases such as tooth sensitivity, gingivitis, dental plaques, gingival atrophy, dental ulcer, oral cavity dysbacteriosis and the like. The composition has synergistic effects and is especially suitable for people requiring implant post-operation gingival care and daily use, gingival repairing and care after tooth extraction, post-operation daily oral cavity care of cardiac valve transplanting, and people being sensitive to oral bacteria and being liable to be affected by various inflammations and viruses. The composition also has the effect of preventing tooth sensitivity and reinforcing teeth and gingiva.
Description
Technical field
The present invention relates to the group of the prevention and control field of oral disease, more particularly to a kind of reinforced gum reparation and mouth care
Compound and its application.
Background technology
Bioactive minerals powder body is a kind of important inorganic bioactivity material, and it has special inorganic amorphous knot
Structure, possesses raising cytoactive and promotes the excellent properties such as biomineralization, is other crystalline state bioactive materials of an analogy
Tissue renovation material that can be more superior.Bioactive minerals powder body was most found that it was into subpackage by professor Hench early in 1969
Include SiO2、Na2O、CaO、P2O5Deng.The catabolite of bioactive minerals powder body can promote the generation of somatomedin, promote thin
The procreation of born of the same parents, strengthens osteoblastic gene expression and the growth of osseous tissue, be so far uniquely can either with osseous tissue into
Bond is closed, while and the bioartificial materials that can be connected with soft tissue, it is considered to be can be applicable to the good life in reparation field
Thing material.The purposes of bioactive minerals powder body is not only extremely wide, and has nothing on the professional product of various fields
Magical effect that method is substituted.As what it was studied gradually gos deep into, bioactive minerals powder body has been widely used in medical science
The preventing and treating in field, such as bone tissue restoration, skin tissue recovering and oral disease.
Patent documentation CN102826752A discloses a kind of bioactive minerals matter powder body containing quasi-nano granule, institute
State the composition that active mineral matter powder body contains following percentage by weight：SiO240～65%, CaO 15～30%, Na2O 15～
30%, P2O52～8%；Its particle size range is less than 90 μm, wherein, the quasi-nano containing aperture in the range of 100～900nm
0.1～20.0wt% of granule.The bioactive minerals diameter of particle that the document is provided is less than 90 μm and includes quasi-nano granule,
Mainly for dentine hypersensitivity problem, effect is to be directly entered dentinal tubule and directly closed to the powder body, so as to shorten
Treatment time simultaneously improves enclosed.Bioactive minerals powder body or other germicides of the document without reference to particle diameter more than 90 μm
Matter, because the larger biological activity powder body of granule can more effectively play the effect such as soft tissue injury in reparation oral cavity, therefore
The product that the document is provided is unable to reach and prevent and treat comprehensively, comprehensively a series of oral problems such as sensitivity of tooth, gingivitiss, oral ulcer
Effect.
Poly-D-lysine is the microbiology class food preservative with superior antiseptic property in natural antiseptic agent.It is by 25
～30 lysine residues are polymerized, and with strong bacteriostasis, can be used for the fresh-keeping of food as preservative.Poly relies
Propylhomoserin antimicrobial spectrum is wide, has good fungistatic effect to gram positive bacteria, gram negative bacteria, yeast, mycete, and right
Some thermostability bacillus cereuss and virus also have certain inhibitory action.
However, oral cavity is the extremely complex environment of a flora, intraoral part antibacterial is all to keeping tooth and gingiva
It is healthy and beneficial and extremely important, if the quantity of these antibacterials is less, decayed tooth and gum disease will be caused.And other are thin
The excessive breeding of bacterium then can work the mischief to tooth, gingiva tissue, cause dental caries, gingival atrophy, bleeding, inflammation, infection, or even
Cause the serious problems such as heart disease, apoplexy and premature labor.
It is contemplated that developing the compositionss of a kind of reinforced gum reparation and mouth care, said composition can effectively put down
Weighing apparatus oral cavity flora, suppresses the breeding and growth of oral cavity harmful bacteria, reaches Comprehensive prevention treatment sensitivity of tooth, gingivitiss, removes tooth
The effect of the oral diseases such as bacterial plaque, gingival atrophy, oral ulcer, oral cavity flora imbalance, with synergy.Compositionss are especially fitted
It is daily for patient after gingiva restoration care, transplantation of heart valve after the postoperative gingiva care of implantation body and routine use, exodontia
Mouth care and it is various oral cavity sensitive bacteria is easily caused various inflammation and virus infection crowd use, while playing preventing and treating tooth
The effect of sensitive, firm tooth and strong gingiva.At present, there is not yet what bioactive minerals powder body and poly-D-lysine were shared
Report.
The content of the invention
It is an object of the invention to provide compositionss and its application of a kind of reinforced gum reparation and mouth care.
The invention provides the compositionss of a kind of reinforced gum reparation and mouth care, its active component includes：It is biological
Active mineral powder body and poly-D-lysine.
Preferably, bioactive minerals powder body described in the compositionss of the reinforced gum reparation and mouth care with it is many
The mass ratio of polylysine is 1～10000:1.
It is further preferred that bioactive minerals powder described in the compositionss of the reinforced gum reparation and mouth care
Body is 10～2000 with the mass ratio of poly-D-lysine:1.
It is further preferred that bioactive minerals described in the compositionss of the reinforced gum reparation and mouth care
Powder body is 20～1000 with the mass ratio of poly-D-lysine:1.
It is preferred that bioactive minerals powder body described in the compositionss of the reinforced gum reparation and mouth care with it is many
The mass ratio of polylysine is 30～220:1.
More preferably, bioactive minerals powder body described in the compositionss of the reinforced gum reparation and mouth care with it is many
The mass ratio of polylysine is 90～180:1.
Bioactive minerals powder body of the present invention contains the composition of following percentage by weight：SiO238～55%, CaO
15～30%, Na2O 15～30%, P2O52～8%, F (i.e. fluorine element) 0.1-10%.
Preferably, the particle size distribution range of the bioactive minerals powder body is 0.1-50 μm；It is further preferred that wherein
The mass fraction of the mineral powder of 0.1≤particle diameter≤20 μm is 40～80%, more preferably 50～75%.
Bioactive minerals raw powder's production technology of the present invention includes：By proportioning by silicon dioxide, Calcium Carbonate, carbonic acid
After sodium, phosphorus pentoxide, fluoride are sufficiently mixed, liquid is fused in 1100 DEG C or so (in high temperature kilns), is incubated (general 2h
Left and right), with water quenching, after drying, grinding, screening is obtained final product.
Preferably, the fluoride includes sodium fluoride (NaF), sodium monofluorophosphate (Na2PO3F), potassium fluoride, fluorite, fluorine phosphorus
One or more in lime stone etc.；More preferably sodium fluoride or sodium monofluorophosphate.
Preferably, the proportioning raw materials：28～45 parts of silicon dioxide, 25～40 parts of Calcium Carbonate, 20～35 parts of sodium carbonate, five
Aoxidize 2～10 parts of two phosphorus, 2～10 parts of sodium monofluorophosphate.
The molecular weight of the poly-D-lysine is preferably 1000-10000, and preferably 3800.
Present invention also offers the preparation containing above-mentioned reinforced gum reparation and the compositionss of mouth care, the preparation by
The compositionss of the reinforced gum reparation and mouth care are separately made, or by the reinforced gum reparation and mouth care
Compositionss and adjuvant composition or make.
In the preparation composition quality fraction of reinforced gum reparation and mouth care be 1～75%, preferably 1～
60%；More preferably 4.5～20%.
Preferably, the preparation is gel or powder.
Preferably, the adjuvant is selected from Polyethylene Glycol, silicon dioxide, glycerol, carbomer, carrageenan, pectin, acesulfame potassium, wood
Sugar alcohol, titanium dioxide, food-grade essence, hyaluronate sodium, shitosan, Margarita powder, aminoacid foaming agent, sodium lauryl sulphate etc.
In one or more.
Preferably, the gel includes the component of following mass parts：Above-mentioned reinforced gum reparation and mouth care
1.5～75 parts of compositionss, 5～25 parts of Polyethylene Glycol, 5～30 parts of silicon dioxide, 30～70 parts of glycerol, 0.2～2 part of thickening agent,
0.1～2 part of assistant taste agent, 0.5～5 part of food-grade essence, 0.3～5 part of foaming agent；
It is further preferred that the gel includes the component of following mass parts：Above-mentioned reinforced gum reparation and oral cavity
3～21 parts of the compositionss of nursing, 5～25 parts of Polyethylene Glycol, 5～60 parts of silicon dioxide, 30～70 parts of glycerol, thickening agent 0.2～2
Part, 0.1～2 part of assistant taste agent, 0.5～5 part of food-grade essence, 0.3～5 part of foaming agent；Wherein it is preferred to, the reinforced tooth
Bioactive minerals powder body described in the compositionss of gum reparation and mouth care and the mass ratio of poly-D-lysine are 90～180:
1。
Preferably, the powder includes the component of following mass parts：The group of above-mentioned reinforced gum reparation and mouth care
1.5～75 parts of compound, 25～95 parts of adjuvant；Preferably, the powder includes the component of following mass parts：Above-mentioned reinforced gingiva
Repair 10～45 parts of the compositionss with mouth care, 35～80 parts of adjuvant；Wherein described adjuvant be the one kind in following material or
Combination in any：Hyaluronate sodium, shitosan, silicon dioxide, Margarita powder etc..Wherein it is preferred to, the reinforced gum reparation and
Bioactive minerals powder body described in the compositionss of mouth care is 90～180 with the mass ratio of poly-D-lysine:1.
Mass parts of the present invention can be mass unit, or its times known to the field of medicaments such as ug, mg, g, kg
Number, such as 1/10,1/100,10 times, 100 times.
Present invention also offers the preparation of the compositionss and the preparation of above-mentioned reinforced gum reparation and mouth care
Method, including by proportioning raw material is taken, and is mixed according to a conventional method.
Wherein, the preparation method of above-mentioned gel is comprised the following steps：
1) high speed under vacuum emulsifying stirring, by formula Polyethylene Glycol, silicon dioxide, glycerol are added；
2) after standing, high speed emulsifying whipping step 1 is continued under vacuo) in products therefrom, add above-mentioned reinforcement by formula
The compositionss of type gum reparation and mouth care (or add the component bioactive minerals powder body of the compositionss, many by proportioning
Polylysine), thickening agent, assistant taste agent, food-grade essence and foaming agent, stir (for example stir 30min)；
3) by step 2) products therefrom vacuum breaker stands, and is in homogeneous thick mastic to mixture, obtain final product.
The vacuum of the vacuum condition is -50～-120kPa.
Speed in the high speed emulsifying stirring is 500～1800 revs/min.
Present invention also offers the compositionss or anti-in preparation containing its preparation of above-mentioned reinforced gum reparation and mouth care
Control the application of the aspects such as the application on dental disorder medicine and dental aestheticses, the reparation in non-treatment purpose；The dentistry disease
Disease includes sensitivity of tooth, gingivitiss, dental plaque, gingival atrophy, oral ulcer, oral cavity flora imbalance, maintenance gingiva, firm tooth
Etc. oral disease.
The combination of reinforced gum reparation of the present invention and mouth care has synergy, and said composition is especially suitable
The daily mouth of patient after gingiva restoration care, transplantation of heart valve after the postoperative gingiva care of implantation body and routine use, exodontia
Chamber nurse and it is various oral cavity sensitive bacteria is easily caused various inflammation and virus infection crowd use, while play preventing and treating tooth it is quick
The effect of sense, firm tooth and strong maintenance gingiva, prevention gingival atrophy etc..
Present invention also offers the using method of above-mentioned composition, with conventional this area gel or unguentum or powder phase
Together.
The reinforced gum reparation and the compositionss of mouth care that the present invention is provided has following characteristics：
1st, the present invention provide reinforced gum reparation and mouth care compositionss, wherein the particle diameter for containing be 0.1～
50 μm of bioactive minerals powder body can effectively alleviate the hemodia symptom that the reasons such as dentinal tubule's exposure are caused；
2nd, the present invention is provided reinforced gum reparation and the compositionss of mouth care, wherein the poly-D-lysine for containing exists
There are strong suppression and killing action to the tens of kinds of pathogenic microorganism such as escherichia coli, gonococcuss, chlamydia trachomatiss in a short time,
Permeability is strong and will not produce drug resistance, serves auxiliary bioactive minerals powder body and plays repair tissue regeneration, accelerates wound
The effect of the resultant effects such as healing；Simultaneously less is affected on oral cavity lactobacilluss, aerobe etc., or do not produce impact.
3rd, the invention provides the application of the compositionss of reinforced gum reparation and mouth care, the application is comprehensive pre-
Anti- treatment sensitivity of tooth, gingivitiss, the effect for removing the oral diseases such as dental plaque, gingival atrophy, oral ulcer, oral cavity flora imbalance
Really, with synergy.Compositionss are particularly suited for gum reparation shield after the postoperative gingiva care of implantation body and routine use, exodontia
Reason, patient's common oral care and various various inflammation and virus sense are easily caused to oral cavity sensitive bacteria after transplantation of heart valve
The crowd of dye uses, while playing the effect of preventing and treating odonthemodia, firm tooth and strong gingiva.
Specific embodiment
Following examples are used to illustrate the present invention, but are not limited to the scope of the present invention.It is unreceipted concrete in embodiment
Technology or condition person, according to technology or condition described by document in the art, or are carried out according to product description.It is used
Reagent or the unreceipted production firm person of instrument, are the conventional products that can be commercially available by regular distributor.
The molecular weight of poly-D-lysine used below is 3800, purchased from the limited public affairs of Zhengzhou, henan Bai Nafo biological engineering shares
Department.Bioactive minerals diameter of particle used below is 0.1～50 μm, wherein the matter of the mineral powder of 0.1≤particle diameter≤20 μm
Amount fraction is 50～75%.
Embodiment 1：The compositionss of reinforced gum reparation and mouth care
Compositionss are consisted of：Bioactive minerals powder body 4.5g, poly-D-lysine 0.135g.
Wherein, bioactive minerals powder body contains the composition of following percentage by weight：SiO240%, CaO 23%, Na2O
28%, P2O55%, F 3%.
Embodiment 2：The compositionss of reinforced gum reparation and mouth care
Compositionss are consisted of：Bioactive minerals powder body 11g, poly-D-lysine 50mg.
Wherein, bioactive minerals powder body contains the composition of following percentage by weight：SiO240%, CaO 23%, Na2O
28%, P2O55%, F 3%.
Embodiment 3：The compositionss of reinforced gum reparation and mouth care
Compositionss are consisted of：Bioactive minerals powder body 50g, poly-D-lysine 0.3g.
Wherein, bioactive minerals powder body contains the composition of following percentage by weight：SiO238%, CaO 24%, Na2O
28%, P2O56%, F 3%.
Embodiment 4：Compositionss of reinforced gum reparation and mouth care and containing its preparation (gel)
1st, the composition of compositionss：Bioactive minerals powder body 4.5g, poly-D-lysine 0.05g.
2nd, the composition of preparation (gel)：Bioactive minerals powder body 4.5g, poly-D-lysine 0.05g, Polyethylene Glycol
20g, silicon dioxide 22g, glycerol 45g, carbomer 0.5g, xylitol 1.5g, food-grade essence 0.5g and sodium lauroyl sarcosine
2g。
The bioactive minerals powder body is with embodiment 1.
3rd, the preparation method of preparation (gel)：By formula add Polyethylene Glycol, silicon dioxide, glycerol, vacuum for-
Under the conditions of 90kpa, 15min is stirred with 1200 revs/min of speed high speed emulsifying；After standing, continue to stir under vacuo, and press
Formula adds the other compositions in formula, continues to stir 30min, is in homogeneous thick mastic to mixture, obtains final product.
Embodiment 5：Compositionss of reinforced gum reparation and mouth care and containing its preparation (gel)
1st, the composition of compositionss：Bioactive minerals powder body 11g, poly-D-lysine 0.1g.
2nd, the composition of preparation (gel)：Bioactive minerals powder body 11g, poly-D-lysine 0.3mg, Polyethylene Glycol 18g,
Silica 1 5g, glycerol 50g, carbomer 1g, xylitol 0.5g, food-grade essence 0.5g and sodium lauryl sulphate 1.5g.
The bioactive minerals powder body is with embodiment 2.
3rd, the preparation method of preparation (gel) is same as Example 4.
Embodiment 6：Compositionss of reinforced gum reparation and mouth care and containing its preparation (powder)
1st, powder composition：Bioactive minerals powder body 50g, poly-D-lysine 0.3g, cross the silicon dioxide 40g of 500 mesh sieves.
The bioactive minerals powder body is with embodiment 3.
2nd, mentioned component is uniformly mixed in mixing apparatus, is obtained final product.
Embodiment 7：Compositionss of reinforced gum reparation and mouth care and containing its preparation (gel)
1st, the composition of compositionss：Bioactive minerals powder body 5g, poly-D-lysine 30mg
2nd, the composition of preparation (gel)：Bioactive minerals powder body 5g, poly-D-lysine 30mg, Polyethylene Glycol 20g, two
Silicon oxide 22g, glycerol 48.5g, carbomer 0.5g, xylitol 1.5g, food-grade essence 0.5g and sodium lauryl sulphate 2g.
The bioactive minerals powder body is with embodiment 3.
3rd, the preparation method of preparation (gel) is same as Example 4.
Comparative example 1
A kind of preparation (gel), replaces poly-D-lysine 0.05g in embodiment 4 with differing only in for embodiment 4
For nanometer silver 8g.
Comparative example 2
A kind of preparation (gel), with its component that differs only in of embodiment 4 bioactive minerals powder body is not included.
Comparative example 3
A kind of preparation (gel), with its component that differs only in of embodiment 4 poly-D-lysine is not included.
Comparative example 4
A kind of preparation (powder), with its component that differs only in of embodiment 6 poly-D-lysine is not included.
Comparative example 5
A kind of preparation (powder), with its component that differs only in of embodiment 6 bioactive minerals powder body is not included.
Comparative example 6
A kind of preparation (powder), differs only in replace with poly-D-lysine 30mg in embodiment 6 and receives with embodiment 6
Rice silver 10g.
The present invention is further illustrated below by way of effect test.
Experimental example 1：Dentinal tubule closes and bacteriostatic experiment
1st, laboratory sample：
Ordinary toothpaste：Commercially available certain brand toothpaste；Gel, powder, the reality of the preparation of comparative example 4-6 prepared by comparative example 1-3
Apply gel, the powder of the preparation of embodiment 6 of the preparation of example 4.
2nd, the preparation of model：The healthy complete premolarss of cattle are taken, tooth is abraded with corundum pin and is closed cover-coat enamel matter, expose tooth sheet
Matter, clips root of the tooth；The baurodont for processing is placed in ultrasonic washing unit, the chip in dentinal tubule is removed.
3rd, Therapeutic Method：By the having on the exposed baurodont of dentinal tubule in moistening of laboratory sample described in each group listed by table 1
Uniform application, after standing 2min, with distilled water flushing, to smear noresidue.
4th, detection method：Dentinal tubule's enclosed is detected under conditions of amplifying 500 times with ultramicroscope.As a result such as
Shown in table 1.
Table 1：The sealing effect of dentinal tubule
The result of table 1 shows：Using 1 group (powder body containing bioactive minerals and nanometer silver) of control, its tooth sheet after 2min is smeared
Matter tubule enclosed is 94%；Using 2 groups of control (containing poly-D-lysine), smearing its dentinal tubule's enclosed after 2min is
25%；Using 3 groups (powder body containing bioactive minerals) of control, it is 92% to smear its dentinal tubule's enclosed after 2min；Use
4 groups (powder body containing bioactive minerals) are compareed, it is 93% to smear its dentinal tubule's enclosed after 2min；Using control, 5 groups (contain
Poly-D-lysine), it is 30% to smear its dentinal tubule's enclosed after 2min；Using 6 groups of (powder body containing bioactive minerals of control
And nanometer silver), it is 95% to smear its dentinal tubule's enclosed after 2min；And dentinal tubule's envelope of embodiment 4, embodiment 6
Close rate and reach 100%.
As a result show：The present invention provide bioactive minerals powder body and poly-D-lysine compositionss have dramatically increase tooth
Tubules enclosed effect, with synergism.
Experimental example 2：Bacteriostatic experiment
1st, laboratory sample：
Ordinary toothpaste：Commercially available certain brand toothpaste；Gel, powder, the reality of the preparation of comparative example 4-6 prepared by comparative example 1-3
Apply gel, the powder of the preparation of embodiment 6 of the preparation of example 4.
2nd, the preparation of model：The healthy complete premolarss of cattle are taken, with thick corundum pin friction tooth cover-coat enamel matter is closed, form thick
Rough surface, clips root of the tooth, is cut into the long sizes of about 1cm；The baurodont for processing is removed into the chip in dentinal tubule, is then distinguished
In infecting escherichia coli, staphylococcus aureuses and the lactobacilluss of same concentrations.
3rd, experimental technique：By laboratory sample described in each group listed by table 2 moistening baurodont model on uniform application, stand
After 3min, with distilled water flushing, to smear noresidue.
4th, detection method：Dental surface clump count is detected under conditions of amplifying 500 times with ultramicroscope after 20min,
Overall colony growth situation is calculated according to each visual field bacterium colony situation.As a result it is as shown in table 2.
5th, further, each group material is cultivated in the medium 36h, with ultramicroscope in the condition for amplifying 500 times
Lower detection dental surface clump count, calculates overall colony growth and calculates long-acting bacteriostatic situation according to each visual field situation.As a result such as
Shown in table 3.
Table 2：Short-term fungistatic effect
Table 3：Long-acting bacteriostatic effect
The result of table 2 shows, using 1 group (powder body containing bioactive minerals and nanometer silver) of control, smears its facing after 3min
Escherichia coli, staphylococcus aureuses, lactobacilluss and Streptococcus mutans are not detected；Illustrate bioactive minerals powder body and nanometer
Silver is used in combination for all of flora has potent short-term bactericidal action；Using 2 groups of control (containing poly-D-lysine), its sound of baby talk
Face escherichia coli, staphylococcus aureuses, lactobacilluss and Streptococcus sanguiss have a small amount of residual；(contain biological activity using 3 groups of control
Mineral powder), its sound of baby talk face escherichia coli, staphylococcus aureuses, lactobacilluss and Streptococcus sanguiss have more residual；Using right
According to 4 groups (powder body containing bioactive minerals), its sound of baby talk face escherichia coli, staphylococcus aureuses, lactobacilluss and Streptococcus sanguiss are equal
There is more residual；Using 5 groups of control (contain poly-D-lysine), its sound of baby talk face escherichia coli, staphylococcus aureuses, lactobacilluss and
Streptococcus sanguiss have a small amount of residual；Using 6 groups of control (containing nanometer silver), its sound of baby talk face escherichia coli, staphylococcus aureuses, breast
Bacillus and Streptococcus sanguiss are not detected；Illustrate nanometer silver potent short-term bactericidal action for all of flora has；Embodiment 4,6
The facing escherichia coli of group, staphylococcus aureuses are and do not detect, but the conventional flora lactobacilluss inspection in oral cavity and blood hammer
Bacterium surveys result a small amount of residual.
The result of table 3 shows that each comparative example grows bacterium colony after cultivating 24 hours, illustrates that its long-acting bacteriostatic is poor.
And the fungistatic effect in experimental example 4 and 6 for escherichia coli and staphylococcus aureuses can keep for a long time, with long well
Effect fungistatic effect.
As a result show：The bioactive minerals powder body and poly-D-lysine compositionss that the present invention is provided has to different mushrooms
Antibacterial effect is selective, can weaken polylysine for oral cavity profitable strain such as lactobacilluss and Streptococcus sanguiss by synergism
Killing effect, be conducive to keeping oral environment balance, and with preferable long-acting bacteriostatic effect, with synergism.
Experimental example 3：Wound healing is tested
1st, laboratory sample：
Normal saline, ordinary toothpaste (commercially available certain brand toothpaste), gel prepared by comparative example 1-3, embodiment 4, enforcement
Gel prepared by example 5, powder prepared by embodiment 6.
2nd, the preparation of model：By rabbit ear local shaving, damaged process is carried out to skin, with thick emery paper polishing rabbit ear skin
Skin, destroys epidermal area, causes 5cm2Skin injury bleeding.
3rd, treatment and detection method：By laboratory sample described in each group listed by table 3 on rabbit ear damaged skin even application, 2
After it, rabbit ear skin healing situation is observed, cicatrix residual condition is observed after five days.
4th, experimental result：It is shown in Table 4.
Table 4：The healing effect of rabbit ear damaged skin
The result of table 4 shows：There is skin surface after 1 group of comparative example (powder body containing bioactive minerals and nanometer silver) is treated 2 days
5% area does not heal；Observe that rabbit auricular defect goes out to have hypertrophy scar tissue after 5 days；2 groups of comparative example (is used alone poly to rely
Propylhomoserin) 25% area have it is fresh go out blood sample residual；Form a scab elsewhere；More scar tissue is observed after 5 days；Comparative example 3
The area that group (bioactive minerals powder body is used alone) wound surface has 5% does not heal；Observing after 5 days has a small amount of scar tissue residual
Stay；Embodiment 4-6 each group heals completely after treating 2 days, without clear scar tissue residue after 5 days.
As a result show：The present invention provide bioactive minerals powder body and poly-D-lysine compositionss have notable antiinflammatory,
The effect of reparing skin defect and suppression cicatrix, and with synergism.
Although above having used general explanation, specific embodiment and test, the present invention is made to retouch in detail
State, but on the basis of the present invention, it can be made some modifications or improvements, this is to those skilled in the art apparent
's.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to the protection model of the present invention
Enclose.
Claims (10)
1. compositionss of a kind of reinforced gum reparation and mouth care, it is characterised in that its active component includes biological activity
Mineral powder and poly-D-lysine；The bioactive minerals powder body is 1～10000 with the mass ratio of poly-D-lysine:1；Institute
State the composition that bioactive minerals powder body contains following percentage by weight：SiO238～55%, CaO 15～30%, Na2O 15
～30%, P2O52～8%, F 0.1-10%；The particle size distribution range of the bioactive minerals powder body is 0.1-50 μm.
2. compositionss of reinforced gum reparation according to claim 1 and mouth care, it is characterised in that the biology
The mass fraction of the mineral powder of 0.1≤particle diameter≤20 μm is 40～80%, preferably 50～75% in active mineral powder body.
3. compositionss of reinforced gum reparation according to claim 1 and 2 and mouth care, it is characterised in that described
Bioactive minerals powder body is 10～2000 with the mass ratio of poly-D-lysine:1；Preferably 20～1000:1；Further preferably
For 30～220:1；More preferably 90～180:1.
4. compositionss of reinforced gum reparation according to claim 1 and 2 and mouth care, it is characterised in that described
Bioactive minerals raw powder's production technology includes：By proportioning by silicon dioxide, Calcium Carbonate, sodium carbonate, phosphorus pentoxide, fluorination
After thing is sufficiently mixed, liquid is fused in 1100 DEG C or so, is incubated, with water quenching, drying, grinding, screening, obtained final product；
Preferably, the fluoride includes the one kind or several in sodium fluoride, sodium monofluorophosphate, potassium fluoride, fluorite, fluor-apatite etc.
Kind.
5. compositionss of reinforced gum reparation according to claim 1 and 2 and mouth care, it is characterised in that described
The molecular weight of poly-D-lysine be 1000-10000, preferably 3800.
6. the preparation of compositionss described in any one of 1-5 containing claim, the preparation is separately made by the compositionss, or by institute
State compositionss and adjuvant composition or make.
7. preparation according to claim 6, wherein the mass fraction of the compositionss be 1～75%, preferably 1～
60%；More preferably 4.5～20%.
8. preparation according to claim 6, it is characterised in that the preparation is gel, including the group of following mass parts
Point：1.5～75 parts of the compositionss, 5～25 parts of Polyethylene Glycol, 5～30 parts of silicon dioxide, 30～70 parts of glycerol, thickening agent 0.2
～2 parts, 0.1～2 part of assistant taste agent, 0.5～5 part of food-grade essence, 0.3～5 part of foaming agent；Preferably, including following mass parts
Component：3～21 parts of the compositionss, 5～25 parts of Polyethylene Glycol, 5～60 parts of silicon dioxide, 30～70 parts of glycerol, thickening agent
0.2～2 part, 0.1～2 part of assistant taste agent, 0.5～5 part of food-grade essence, 0.3～5 part of foaming agent；
It is further preferred that the mass ratio of bioactive minerals powder body described in the compositionss and poly-D-lysine be 90～
180:1。
9. preparation according to claim 6, it is characterised in that the preparation is powder, including the component of following mass parts：
1.5～75 parts of the compositionss, 25～95 parts of adjuvant；Preferably, including following mass parts component：The compositionss 10～45
Part, 35～80 parts of adjuvant；
It is further preferred that the mass ratio of bioactive minerals powder body described in the compositionss and poly-D-lysine be 90～
180:1。
10. the preparation described in compositionss described in any one of claim 1-5 or any one of claim 6-9 is preparing preventing and treating tooth
Application on the medicine of section's disease, or the application in terms of the dental aestheticses of non-treatment purpose, reparation；Preferably, the dentistry
Disease includes sensitivity of tooth, gingivitiss, dental plaque, gingival atrophy, oral ulcer, oral cavity flora imbalance, maintenance gingiva, firm tooth
Tooth.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108096226A (en) * | 2018-01-12 | 2018-06-01 | 南阳师范学院 | A kind of film for treating oral ulcer containing polylysine and preparation method thereof |
| CN113425898A (en) * | 2021-07-19 | 2021-09-24 | 广东省科学院微生物研究所(广东省微生物分析检测中心) | Degradable anti-infection calcium phosphate bone repair composite material and preparation method thereof |
| CN115518004A (en) * | 2022-01-13 | 2022-12-27 | 海尼达(江苏)医疗科技有限公司 | Composition for assisting in improving oral health and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004123630A (en) * | 2002-10-03 | 2004-04-22 | Chisso Corp | Cariostatic and antiperiodontic composition |
| CN102826752A (en) * | 2012-08-23 | 2012-12-19 | 北京大清生物技术有限公司 | Bioactive mineral powder containing quasi-nanometer particles, preparation method and application thereof in dental treatment |
| CN103961371A (en) * | 2014-05-08 | 2014-08-06 | 北京刷新活力健康科技有限公司 | Dental treatment medicine having multiple effects and composition thereof |
-
2016
- 2016-11-25 CN CN201611056648.6A patent/CN106581060B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004123630A (en) * | 2002-10-03 | 2004-04-22 | Chisso Corp | Cariostatic and antiperiodontic composition |
| CN102826752A (en) * | 2012-08-23 | 2012-12-19 | 北京大清生物技术有限公司 | Bioactive mineral powder containing quasi-nanometer particles, preparation method and application thereof in dental treatment |
| CN103961371A (en) * | 2014-05-08 | 2014-08-06 | 北京刷新活力健康科技有限公司 | Dental treatment medicine having multiple effects and composition thereof |
Non-Patent Citations (1)
| Title |
|---|
| 张余善译: "口腔卫生用品的技术进展", 《日用化学品科学》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108096226A (en) * | 2018-01-12 | 2018-06-01 | 南阳师范学院 | A kind of film for treating oral ulcer containing polylysine and preparation method thereof |
| CN108096226B (en) * | 2018-01-12 | 2021-08-31 | 南阳师范学院 | Oral ulcer film containing polylysine and preparation method thereof |
| CN113425898A (en) * | 2021-07-19 | 2021-09-24 | 广东省科学院微生物研究所(广东省微生物分析检测中心) | Degradable anti-infection calcium phosphate bone repair composite material and preparation method thereof |
| CN113425898B (en) * | 2021-07-19 | 2022-11-08 | 广东省科学院微生物研究所(广东省微生物分析检测中心) | Degradable anti-infection calcium phosphate bone repair composite material and preparation method thereof |
| CN115518004A (en) * | 2022-01-13 | 2022-12-27 | 海尼达(江苏)医疗科技有限公司 | Composition for assisting in improving oral health and application thereof |
| CN115518004B (en) * | 2022-01-13 | 2024-01-16 | 海尼达(江苏)医疗科技有限公司 | Composition for assisting in improving oral health and application thereof |
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| Publication number | Publication date |
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| CN106581060B (en) | 2020-02-07 |
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