CN105769609B - With antibacterial, except the dentifrice composition of spot and whitening function - Google Patents
With antibacterial, except the dentifrice composition of spot and whitening function Download PDFInfo
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- CN105769609B CN105769609B CN201410803674.5A CN201410803674A CN105769609B CN 105769609 B CN105769609 B CN 105769609B CN 201410803674 A CN201410803674 A CN 201410803674A CN 105769609 B CN105769609 B CN 105769609B
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- whitening function
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- 239000000203 mixture Substances 0.000 title claims abstract description 53
- 239000000551 dentifrice Substances 0.000 title claims abstract description 43
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 33
- 230000002087 whitening effect Effects 0.000 title claims abstract description 33
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 36
- 102000004190 Enzymes Human genes 0.000 claims abstract description 32
- 108090000790 Enzymes Proteins 0.000 claims abstract description 32
- 239000004094 surface-active agent Substances 0.000 claims abstract description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000008367 deionised water Substances 0.000 claims abstract description 13
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 13
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 7
- 239000004909 Moisturizer Substances 0.000 claims abstract description 3
- 239000007767 bonding agent Substances 0.000 claims abstract description 3
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 3
- 238000000227 grinding Methods 0.000 claims abstract description 3
- 230000001333 moisturizer Effects 0.000 claims abstract description 3
- 239000003765 sweetening agent Substances 0.000 claims abstract description 3
- 239000003205 fragrance Substances 0.000 claims abstract 2
- 229940088598 enzyme Drugs 0.000 claims description 29
- 102000016943 Muramidase Human genes 0.000 claims description 28
- 108010014251 Muramidase Proteins 0.000 claims description 28
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims description 28
- 229960000274 lysozyme Drugs 0.000 claims description 28
- 239000004325 lysozyme Substances 0.000 claims description 28
- 235000010335 lysozyme Nutrition 0.000 claims description 28
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 20
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 18
- 102000003820 Lipoxygenases Human genes 0.000 claims description 16
- 108090000128 Lipoxygenases Proteins 0.000 claims description 16
- 239000004382 Amylase Substances 0.000 claims description 15
- 102000013142 Amylases Human genes 0.000 claims description 15
- 108010065511 Amylases Proteins 0.000 claims description 15
- 108010015776 Glucose oxidase Proteins 0.000 claims description 15
- 239000004366 Glucose oxidase Substances 0.000 claims description 15
- 102000004882 Lipase Human genes 0.000 claims description 15
- 108090001060 Lipase Proteins 0.000 claims description 15
- 239000004367 Lipase Substances 0.000 claims description 15
- 235000019418 amylase Nutrition 0.000 claims description 15
- 229940116332 glucose oxidase Drugs 0.000 claims description 15
- 235000019420 glucose oxidase Nutrition 0.000 claims description 15
- 235000019421 lipase Nutrition 0.000 claims description 15
- 241000191940 Staphylococcus Species 0.000 claims description 14
- 235000013305 food Nutrition 0.000 claims description 11
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 10
- 102100032487 Beta-mannosidase Human genes 0.000 claims description 10
- 241000206575 Chondrus crispus Species 0.000 claims description 10
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 10
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 10
- 229910021502 aluminium hydroxide Inorganic materials 0.000 claims description 10
- 108010055059 beta-Mannosidase Proteins 0.000 claims description 10
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- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 claims description 10
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- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 10
- 125000000217 alkyl group Chemical group 0.000 claims description 9
- 229920001285 xanthan gum Polymers 0.000 claims description 9
- 108091005804 Peptidases Proteins 0.000 claims description 5
- 239000004365 Protease Substances 0.000 claims description 5
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims description 5
- 235000019419 proteases Nutrition 0.000 claims description 5
- 150000001721 carbon Chemical group 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 2
- 150000001335 aliphatic alkanes Chemical class 0.000 claims 1
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 abstract description 28
- 230000000694 effects Effects 0.000 abstract description 21
- 208000002064 Dental Plaque Diseases 0.000 abstract description 16
- 239000000049 pigment Substances 0.000 abstract description 16
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- 210000000214 mouth Anatomy 0.000 abstract description 8
- 238000000034 method Methods 0.000 abstract description 7
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 abstract description 6
- 230000001580 bacterial effect Effects 0.000 abstract description 6
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- 238000010276 construction Methods 0.000 abstract description 4
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- 230000003647 oxidation Effects 0.000 abstract description 3
- 238000007254 oxidation reaction Methods 0.000 abstract description 3
- 238000001179 sorption measurement Methods 0.000 abstract description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 27
- 241000894006 Bacteria Species 0.000 description 18
- -1 Alkyl phenol Chemical compound 0.000 description 13
- 229940051841 polyoxyethylene ether Drugs 0.000 description 11
- 229920000056 polyoxyethylene ether Polymers 0.000 description 11
- 238000003756 stirring Methods 0.000 description 11
- 239000000606 toothpaste Substances 0.000 description 10
- 229940034610 toothpaste Drugs 0.000 description 10
- LGRFSURHDFAFJT-UHFFFAOYSA-N Phthalic anhydride Natural products C1=CC=C2C(=O)OC(=O)C2=C1 LGRFSURHDFAFJT-UHFFFAOYSA-N 0.000 description 8
- JHIWVOJDXOSYLW-UHFFFAOYSA-N butyl 2,2-difluorocyclopropane-1-carboxylate Chemical compound CCCCOC(=O)C1CC1(F)F JHIWVOJDXOSYLW-UHFFFAOYSA-N 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 7
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- CYEJMVLDXAUOPN-UHFFFAOYSA-N 2-dodecylphenol Chemical compound CCCCCCCCCCCCC1=CC=CC=C1O CYEJMVLDXAUOPN-UHFFFAOYSA-N 0.000 description 3
- DUIOKRXOKLLURE-UHFFFAOYSA-N 2-octylphenol Chemical compound CCCCCCCCC1=CC=CC=C1O DUIOKRXOKLLURE-UHFFFAOYSA-N 0.000 description 3
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- 238000010998 test method Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 3
- 238000010792 warming Methods 0.000 description 3
- NFAOATPOYUWEHM-UHFFFAOYSA-N 2-(6-methylheptyl)phenol Chemical compound CC(C)CCCCCC1=CC=CC=C1O NFAOATPOYUWEHM-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000000721 bacterilogical effect Effects 0.000 description 2
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 description 2
- 229940092714 benzenesulfonic acid Drugs 0.000 description 2
- 239000007844 bleaching agent Substances 0.000 description 2
- 239000006161 blood agar Substances 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000000084 colloidal system Substances 0.000 description 2
- 230000001332 colony forming effect Effects 0.000 description 2
- 210000003298 dental enamel Anatomy 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 150000003904 phospholipids Chemical class 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- 239000002344 surface layer Substances 0.000 description 2
- QJZYHAIUNVAGQP-UHFFFAOYSA-N 3-nitrobicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid Chemical compound C1C2C=CC1C(C(=O)O)C2(C(O)=O)[N+]([O-])=O QJZYHAIUNVAGQP-UHFFFAOYSA-N 0.000 description 1
- 208000010266 Aggressive Periodontitis Diseases 0.000 description 1
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 description 1
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 238000004061 bleaching Methods 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
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- 239000012459 cleaning agent Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
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- 239000003814 drug Substances 0.000 description 1
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- 238000002474 experimental method Methods 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 239000004021 humic acid Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 210000002189 macula lutea Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
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- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 description 1
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- 201000006727 periodontosis Diseases 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
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Landscapes
- Cosmetics (AREA)
Abstract
There is antibacterial, except the dentifrice composition of spot and whitening function, including grinding agent, moisturizer, bonding agent, diester-type surfactant, complex enzyme, sweetener, fragrance, activated carbon, deionized water the invention discloses a kind of.The present invention has antibacterial, except established plaque is decomposed in the biological enzyme collaboration in the dentifrice composition of spot and whitening function, and decompose control of microorganisms its formed Dental plaque biofilm, and pigment of the residual in the oral cavity or on tooth and carbohydrate are decomposed to generate hydrogen peroxide or hydroperoxides by biological enzyme, hydrogen peroxide and hydroperoxides can carry out bacterial cell oxidation killing, while hydrogen peroxide also has blanching effect；For the pigment for failing to decompose and broken thalline, is removed using activated carbon adsorption and using the method for the diester-type surfactant washing with special construction, achieve the effect that antibacterial, except spot and whitening, full-featured, significant effect.
Description
Technical field
The invention belongs to daily necessities technical field, especially a kind of containing with antibacterial, except spot and whitening function
Enzyme dentifrice composition.
Background technology
Dental plaque biofilm is the ecosystem that varied flora on facing or in oral pocket is constituted.Bacterium is raw inside
Long, development and decline.Its complicated structure enables it to forgive the bacterium to oxygen difference sensibility, these bacteriums are embedded in by more
In the matrix of sugar, protein and minerals composition.The metabolic activity of bacterium wherein, affects between bacterium and host or bacterium
Dynamic equilibrium between Pseudomonas.Dental plaque biofilm is present in the surface of nearly all tooth, and is firmly stuck to tooth table
Face, or even be also difficult to be removed by violent activity of brushing teeth.After forming plaque on tooth, if not in time and effectively
It removes, plaque will constantly expand and eventually lead to the periodontosis and saprodontia and tooth of gingivitis, periodontitis and other forms
Calculus.The core of removal plaque is to remove the extracellular polymeric of microorganism secretion.The constituent of extracellular polymeric is relatively more
Sample, component is because the difference of derived microbial is also variant, but generally speaking, extracellular polymeric is mainly by protein, polysaccharide, core
The compositions such as acid, uronic acid, lipid, humic acid, amino acid.Protein and polysaccharide are its main components, account for extracellular polymeric total amount
70 ~ 80%.Various biological enzyme are commonly used in the extracellular polymeric of removal microorganism, the effect of biological enzyme is to decompose extracellular polymer
Object, microorganism cell wall and cell membrane, to reach inhibit microorganism growth and its formed Dental plaque biofilm.However,
Oral microorganism itself can resist the decomposition of exogenous biological enzyme with secretase to degrade exogenous biological enzyme so that outer
The efficacy wanes of source property biological enzyme.In addition, high-caliber sulfydryl can neutralize oxygroup in Dental plaque biofilm, protection bacterial cell is exempted from
Oxidative damage, protection flora resist oral cavity harsh environment, bacterium are made to remain to retain in unsuitable condition.
Dental exogenous mottle is mainly due to drinking beverage containing pigment, edible having the food of pigment and smoking to cause
's.Dental exogenous mottle is common in crowd, influences beauty.Dental plaque biofilm is also the place of pigment deposition, except going
Property color spot in source refers to the color spot for removing facing Acquired Pellicle and enamel surface layer, mainly using the ingredient for having certain attriting performance
Removal and removes intrinsic staining then and needs with the drug that can penetrate into facing institutional framework positioned at the color spot on enamel surface layer, such as
Hydrogen peroxide etc. plays blanching effect.Toothpaste energy bleaching teeth is bleached, cigarette stain on tooth, tea stain, coffee stain can be effectively eliminated
Deng, it is deep to be welcome by domestic and international consumer, but bleach and be often directly added into chemical bleaching agent in toothpaste, such as it is directly added into peroxidating
Hydrogen, the hydrogen peroxide that this form is added have larger stimulation to oral cavity, keep human body uncomfortable.
Existing dentifrice composition has a single function mostly, and ineffective.
Invention content
For the above-mentioned fact, present inventor is by further investigation, and design is by biological enzyme to established plaque
Decomposed, and decompose control of microorganisms its formed Dental plaque biofilm, and by biological enzyme decompose residual in the oral cavity or
Pigment and carbohydrate on tooth generate hydrogen peroxide or hydroperoxides, and hydrogen peroxide and hydroperoxides can be to bacterial cells
Oxidation killing is carried out, while hydrogen peroxide also has blanching effect；For the pigment for failing to decompose and broken thalline, using work
Property charcoal absorption and using with special construction diester-type surfactant washing method removal；Pass through above-mentioned various works
With achieving the effect that antibacterial, except spot and whitening.
In order to solve the above technical problems, the technical solution adopted by the present invention is：There is provided one kind having antibacterial, removes spot and whitening
The dentifrice composition of function, including grinding agent, moisturizer, bonding agent, diester-type surfactant, complex enzyme, sweetener, perfume (or spice)
Material, activated carbon, deionized water；The complex enzyme be protease, lipase, amylase, lipoxygenase, glucose oxidase,
The combination of phosphatidase, pectase, mannonase staphylococcus lysozyme and lysozyme, the diester-type surfactant are tool
There is formula（1）The compound of shown structure：
（1）
Formula（1）In, R indicates the alkyl of different carbon atom numbers, the integer that the carbon atom number of R is 8 ~ 18；N is ethylene oxide ether
Unit number, the integer that n is 210 ~ 500.
Preferably, the alkyl is straight chained alkyl or branched alkyl.Straight chained alkyl or branched alkyl make diester-type surface
Two carbochains of activating agent have good hydrophobicity, are conducive to remove pigment and broken thalline.
Preferably, the integer that the n is 240 ~ 400.For toothpaste, surfactant will have certain foaminess
Can, otherwise influence the cleaning action of toothpaste.When the unit number of the ethylene oxide ether of diester-type surfactant is 240 ~ 400, it can make
Diester-type surfactant has good foam performance, can guarantee the cleaning performance of toothpaste.
Most preferably, the integer that the n is 360.For toothpaste, the foam that surfactant generates should not be excessive,
Otherwise it influences to use.When the unit number of the ethylene oxide ether of diester-type surfactant is 360, diester-type surfactant is not only
Have foam performance, and bubble amt optimum.
Specifically, described to there is antibacterial, except the dentifrice composition of spot and whitening function is by the component of following weight percent
Composition：
Hydrated silica 20 ~ 35%；Aluminium hydroxide 20 ~ 35%；
Polypropylene glycol 4 ~ 7%；Glycerine 8 ~ 14%；
Sodium carboxymethylcellulose 0.3 ~ 0.5%；Xanthans 0.3 ~ 0.6%；
Carragheen 0.8 ~ 1.2%；Diester-type surfactant 1 ~ 3%；
Food flavor 1 ~ 1.5%；Saccharin sodium 0.18 ~ 0.28%；
Proteinase-10 .03 ~ 0.08%；Lipase 0.01 ~ 0.03%；
Amylase 0.01 ~ 0.03%；Lipoxygenase 0.1 ~ 0.5%；
Glucose oxidase 0.1 ~ 0.5%；Phosphide enzyme 0.01 ~ 0.04%；
Pectase 0.01 ~ 0.03%；Mannase 0.01 ~ 0.03%
Staphylococcus lysozyme 0.01 ~ 0.04%；Lysozyme 0.02 ~ 0.05%；
Activated carbon 5 ~ 10%；Deionized water 12 ~ 20%.
Preferably, described to there is antibacterial, except the dentifrice composition of spot and whitening function is by the component of following weight percent
Composition：
Hydrated silica 24 ~ 32%；Aluminium hydroxide 25 ~ 30%；
Polypropylene glycol 4 ~ 7%；Glycerine 10 ~ 12%；
Sodium carboxymethylcellulose 0.45 ~ 0.5%；Xanthans 0.3 ~ 0.45%；
Carragheen 0.8 ~ 1%；Diester-type surfactant 1 ~ 2%；
Food flavor 1.3 ~ 1.5%；Saccharin sodium 0.18 ~ 0.2%；
Proteinase-10 .06 ~ 0.08%；Lipase 0.015 ~ 0.025%；
Amylase 0.01 ~ 0.02%；Lipoxygenase 0.3 ~ 0.5%；
Glucose oxidase 0.3 ~ 0.5%；Phosphide enzyme 0.01 ~ 0.02%；
Pectase 0.01 ~ 0.02%；Mannase 0.01 ~ 0.02%；
Staphylococcus lysozyme 0.03 ~ 0.04%；Lysozyme 0.04 ~ 0.05%；
Activated carbon 6 ~ 8%；Deionized water 12.365 ~ 17.895%.
Subject using it is above-mentioned preferably combine there is antibacterial, except after the dentifrice composition of spot and whitening function, average bacterium
It is 71.3 ~ 72.2% to fall and to form the reduced rate of unit, and amount of bacteria substantially reduces；Average dental plaque index reduced rate is 56.9 ~
59.4%, plaque removal effect is notable；Average color spot index reduced rate is 60.5 ~ 62.7%, tooth-whitening significant effect.
Most preferably, described to there is antibacterial, except the dentifrice composition of spot and whitening function is by the group of following weight percent
Part composition：
Hydrated silica 28%；Aluminium hydroxide 28%；
Polypropylene glycol 5%；Glycerine 10%；
Sodium carboxymethylcellulose 0.5%；Xanthans 0.4%；
Carragheen 0.8%；Diester-type surfactant 1.5%；
Food flavor 1.5%；Saccharin sodium 0.2%；
Proteinase-10 .08%；Lipase 0.02%；
Amylase 0.01%；Lipoxygenase 0.5%；
Glucose oxidase 0.4%；Phosphatidase 0.02%；
Pectase 0.01%；Mannase 0.01%；
Staphylococcus lysozyme 0.04%；Lysozyme 0.05%；
Activated carbon 7%；Deionized water 15.96%.
Subject most preferably has antibacterial, except after the dentifrice composition of spot and whitening function using above-mentioned, average colony
The reduced rate for forming unit is 78.5%, and amount of bacteria substantially reduces；Average dental plaque index reduced rate is 65.8%, plaque removal
Significant effect；Average color spot index reduced rate is 67.7%, tooth-whitening significant effect.
The present invention's plays collaboration work with antibacterial, except the various biological enzyme in the dentifrice composition of spot and whitening function
With, wherein protease, lipase, amylase, pectase and mannase decompose the extracellular polymeric of plaque flora secretion,
The microbial exposure being hidden in extracellular polymeric is set to come out；Lipoxygenase decomposes residual fatty spot in the oral cavity and extracellular
Lipid in polymer simultaneously generates hydroperoxides, and with pigment coupling reaction can also occur for lipoxygenase, and pigment of degrading make tooth
Tooth removes macula lutea, tooth-whitening；Glucose oxidase decomposes the carbohydrate in desizing spot and extracellular polymeric in oral cavity and production
During raw hydrogen peroxide, hydroperoxides and hydrogen peroxide can not only be to high-caliber sulfydryl aoxidize in Dental plaque biofilm
With, and continue to carry out oxidation killing to bacterial cell after the neutralization, its exogenous biology enzyme effect of reduction bacterial cell
It resists；In addition, hydrogen peroxide has blanching effect, the intrinsic staining of tooth can be removed；Staphylococcus lysozyme, lysozyme and phosphorus
Lipase decomposes the cell wall and cell membrane of microorganism, to kill microorganism；For fail decompose pigment and broken thalline,
Using activated carbon adsorption and using the method removal of the diester-type surfactant washing with special construction, diester-type surface is lived
Two hydrophobic carbochains of property agent pass through the phospholipid bilayer of intermolecular active force adsorpting pigment and broken bacterium, hydrophobic carbochain
The phenyl ring of connection enhances the adsorption capacity of hydrophobic carbochain and pigment and the phospholipid bilayer of broken bacterium, while diester-type surface
Activating agent has suitable foam performance again, reinforces the removing of pigment and broken thalline.
It is understood that may include by protease, fat other than toothpaste, in the matrix components of cleaning agent for mouth cavity
Enzyme, amylase, lipoxygenase, glucose oxidase, phosphatidase, mannonase pectase, staphylococcus lysozyme, bacteriolyze
The complex enzyme of enzyme composition, activated carbon and the diester-type surfactant；May include by egg in the matrix components of chewing gum
White enzyme, lipase, amylase, lipoxygenase, glucose oxidase, phosphatidase, mannonase pectase, molten grape ball
The complex enzyme and activated carbon of bacterium enzyme, lysozyme composition.
The beneficial effects of the invention are as follows：It is had a single function mostly for existing dentifrice composition and ineffective situation,
The present invention has antibacterial, except the biological enzyme collaboration in the dentifrice composition of spot and whitening function divides established plaque
Solution, and decompose control of microorganisms its formed Dental plaque biofilm, and by biological enzyme decompose residual in the oral cavity or on tooth
Pigment and carbohydrate generate hydrogen peroxide or hydroperoxides, hydrogen peroxide and hydroperoxides can carry out oxygen to bacterial cell
Change killing, while hydrogen peroxide also has blanching effect；For the pigment for failing to decompose and broken thalline, inhaled using activated carbon
The method removal using the diester-type surfactant washing with special construction is echoed, by above-mentioned various effects, is reached
To antibacterial, except the effect of spot and whitening, full-featured, significant effect.
Specific implementation mode
The following describes the present invention in detail with reference to examples.
Embodiment 1
In the reaction kettle of the esterification for carrying condenser, water knockout drum at 10 liters, 5 kilograms of toluene, 4.48 kilograms of straight chains are sequentially added
Octyl phenol polyoxyethylene ether（Alkyl phenol polyoxyethylene ether, R=8, n=210）, 0.52 kilogram of phthalic anhydride, with 150 revs/min
The mixing speed of clock stirs 30 minutes, makes straight chain octyl phenol polyoxyethylene ether（Alkyl phenol polyoxyethylene ether, R=8, n=210）And neighbour
Phthalate anhydride is completely dissolved in toluene；0.05 kilogram of p-methyl benzenesulfonic acid is added, and with 150 revs/min of stirring speed
Degree stirring 10 minutes, Catalyzed by P-Toluenesulfonic Acid straight chain octyl phenol polyoxy ether（Alkyl phenol polyoxyethylene ether, R=8, n=210）With
Esterification occurs for phthalic anhydride；110 DEG C are warming up to, and small with the stirring of 150 revs/min of mixing speed, back flow reaction 4
When；The water in water knockout drum is finally removed, toluene is extracted using vacuum pump, is cooled to room temperature, obtain diester-type surfactant, it should
Diester-type surfactant structure is as follows：
（R=8）.
Embodiment 2
At 10 liters with condenser, water knockout drum reaction kettle of the esterification in, sequentially add 5 kilograms of toluene, 4.92 kilograms it is different pungent
Base phenol polyethenoxy ether（Alkyl phenol polyoxyethylene ether, R=12, n=500）, 0.08 kilogram of phthalic anhydride, with 150 revs/min
Mixing speed stir 30 minutes, make isooctyl phenol polyethoxylate（Alkyl phenol polyoxyethylene ether, R=12, n=500）With adjacent benzene
Dicarboxylic acid anhydride is completely dissolved in toluene；0.003 kg of phosphoric acid is added, and 10 points are stirred with 150 revs/min of mixing speed
Clock, phosphoric acid catalyzed isooctylphenol polyoxy ether（Alkyl phenol polyoxyethylene ether, R=12, n=500）Ester occurs with phthalic anhydride
Change reaction；It is warming up to 110 DEG C, and with the stirring of 150 revs/min of mixing speed, back flow reaction 4 hours；Finally remove water knockout drum
In water, extract toluene using vacuum pump, be cooled to room temperature, obtain diester-type surfactant, the diester-type surfactant
Structure is as follows：
（R=12）.
Embodiment 3
In the reaction kettle of the esterification for carrying condenser, water knockout drum at 10 liters, 5 kilograms of toluene, 4.85 kilograms of straight chains are sequentially added
Dodecyl phenol polyethenoxy ether（Alkyl phenol polyoxyethylene ether, R=18, n=360）, 0.15 kilogram of phthalic anhydride, with 150
Rev/min mixing speed stir 30 minutes, make straight chain dodecyl phenol polyethenoxy ether（Alkyl phenol polyoxyethylene ether, R=18,
n=360）It is completely dissolved in toluene with phthalic anhydride；It adds 0.02 kilogram of benzene sulfonic acid, and is stirred with 150 revs/min
It mixes speed to stir 10 minutes, benzene sulfonic acid is catalyzed straight chain dodecylphenol polyoxy ether（Alkyl phenol polyoxyethylene ether, R=18, n=
360）Esterification occurs with phthalic anhydride；110 DEG C are warming up to, and with the stirring of 150 revs/min of mixing speed, reflux
Reaction 4 hours；The water in water knockout drum is finally removed, toluene is extracted using vacuum pump, is cooled to room temperature, obtains the work of diester-type surface
Property agent, the diester-type surfactant structure are as follows：
（R=18）.
Embodiment 4
It is consisted of the following compositions with antibacterial, except the dentifrice composition of spot and whitening function（Weight percent）：
Hydrated silica 28%；Aluminium hydroxide 28%；
Polypropylene glycol 5%；Glycerine 10%；
Sodium carboxymethylcellulose 0.5%；Xanthans 0.4%；
Carragheen 0.8%；Diester-type surfactant 1.5% made from embodiment 3；
Food flavor 1.5%；Saccharin sodium 0.2%；
Proteinase-10 .08%；Lipase 0.02%；
Amylase 0.01%；Lipoxygenase 0.5%；
Glucose oxidase 0.4%；Phosphatidase 0.02%；
Pectase 0.01%；Mannase 0.01%；
Staphylococcus lysozyme 0.04%；Lysozyme 0.05%；
Activated carbon 7%；Deionized water 15.96%.
Preparation method is as follows：
One, complex enzyme is prepared
By above-mentioned weight percent, by protease, lipase, amylase, lipoxygenase, glucose oxidase, phosphatide
Enzyme, pectase, mannonase staphylococcus lysozyme and lysozyme are uniformly mixed；
Two, glue
By above-mentioned weight percent, by hydrated silica, aluminium hydroxide, polypropylene glycol, glycerine, sodium carboxymethylcellulose, Huang
Virgin rubber, carragheen, diester-type surfactant, food flavor, complex enzyme and deionized water uniform stirring made from embodiment 3,
Colloid is made；
Three, it mediates
By above-mentioned weight percent, saccharin sodium and activated carbon are added in colloid, stirs evenly and deaerates, lotion is made.
Embodiment 5
It is consisted of the following compositions with antibacterial, except the dentifrice composition of spot and whitening function（Weight percent）：
Hydrated silica 32%；Aluminium hydroxide 25%；
Polypropylene glycol 4%；Glycerine 12%；
Sodium carboxymethylcellulose 0.45%；Xanthans 0.45%；
Carragheen 1%；Diester-type surfactant 2% made from embodiment 1；
Food flavor 1.3%；Saccharin sodium 0.18%；
Proteinase-10 .08%；Lipase 0.025%；
Amylase 0.01%；Lipoxygenase 0.5%；
Glucose oxidase 0.5%；Phosphatidase 0.01%；
Pectase 0.02%；Mannase 0.02%；
Staphylococcus lysozyme 0.04%；Lysozyme 0.05%；
Activated carbon 8%；Deionized water 12.365%.
Preparation method is the same as embodiment 4.
Embodiment 6
It is consisted of the following compositions with antibacterial, except the dentifrice composition of spot and whitening function（Weight percent）：
Hydrated silica 24%；Aluminium hydroxide 30%；
Polypropylene glycol 7%；Glycerine 10%；
Sodium carboxymethylcellulose 0.5%；Xanthans 0.3%；
Carragheen 0.8%；Diester-type surfactant 1% made from embodiment 2；
Food flavor 1.5%；Saccharin sodium 0.2%；
Proteinase-10 .06%；Lipase 0.015%；
Amylase 0.02%；Lipoxygenase 0.3%；
Glucose oxidase 0.3%；Phosphatidase 0.02%；
Pectase 0.01%；Mannase 0.01%；
Staphylococcus lysozyme 0.03%；Lysozyme 0.04%；
Activated carbon 6%；Deionized water 17.895%.
Preparation method is the same as embodiment 4.
Embodiment 7
The antibacterial functions of the dentifrice composition of the present invention
One, material is tried out：The dentifrice composition of embodiment 4 ~ 6.
Two, object is tried out：30 subjects.
Three, test method：
30 subjects are randomly divided into 3 groups, respectively 6 groups, every group 10 of 4 groups of embodiment, 5 groups of embodiment and embodiment
Name；Subject aspirates in tongue back side to collect bacterium, then by the sample blood agar culture-medium of collection before experiment
It is cultivated under 37 DEG C of anaerobic condition, after 72 hours, calculates average bacteriological Colony Forming Unit（Baseline）, then subject
The dentifrice composition for using the present embodiment 4 ~ 6 respectively brushes teeth each 1 time sooner or later, uses 2 grams of toothpaste every time, continue 3 months daily,
It is brushed teeth using horizontal trembling method；After 3 months, subject aspirates in the tongue back other side to collect bacterium, then by collection
Sample is cultivated with blood agar culture-medium under 37 DEG C of anaerobic condition, after 72 hours, is calculated average bacteriological bacterium colony and is formed list
Position, the average colony for comparing subject before and after the dentifrice composition using the present embodiment 4 ~ 6 form the variation of unit results.
Four, test result：
| Group | Baseline is averaged CFU | Use average CFU after 3 months | The reduced rate % of average CFU based on baseline |
| 4 groups of embodiment | 9.3×105 | 2.0×105 | 78.5 |
| 5 groups of embodiment | 8.7×105 | 2.5×105 | 71.3 |
| 6 groups of embodiment | 7.9×105 | 2.2×105 | 72.2 |
CFU=Colony Forming Unit
Average CFU reduced rates=[（The baseline CFU- that is averaged uses CFU average values after 3 months）/ baseline is averaged CFU] × 100%.
As seen from the above table, there is antibacterial, except after the dentifrice composition of spot and whitening function using the present invention, average colony
The reduced rate for forming unit is 71.3 ~ 78.5%, and amount of bacteria substantially reduces.
Embodiment 8
The plaque of the dentifrice composition of the present invention removes effect
One, material is tried out：The dentifrice composition of embodiment 4 ~ 6.
Two, object is tried out：30 subjects.
Three, test method：
30 subjects are randomly divided into 3 groups, respectively 6 groups, every group 10 of 4 groups of embodiment, 5 groups of embodiment and embodiment
Name；Subject uses the dentifrice composition of the present embodiment 4 ~ 6 respectively, brushes teeth daily each 1 time sooner or later, uses 2 grams of toothpaste every time, hold
It is 3 months continuous, it is brushed teeth using horizontal trembling method；Investigate using the present embodiment 4 ~ 6 dentifrice composition before and after subject plaque
Index（PLI）Variation.Dental plaque index（PLI）Calculate average value.
Four, test result：
Dental plaque index reduced rate=[（3 months Dental Plaque indexes are used using preceding dental plaque index-）/ use labial teeth bacterium
Spot index] × 100%.
As seen from the above table, using the tool antibacterial of the present invention, except after the dentifrice composition of spot and whitening function, dental plaque index
For reduced rate up to 56.9 ~ 65.8%, plaque removal effect is notable.
Embodiment 9
The whitening function of the dentifrice composition of the present invention
One, material is tried out：The dentifrice composition of embodiment 4 ~ 6.
Two, object is tried out：30 subjects.
Three, test method：
30 subjects are randomly divided into 3 groups, respectively 6 groups, every group 10 of 4 groups of embodiment, 5 groups of embodiment and embodiment
Name；Subject uses the dentifrice composition of the present embodiment 4 ~ 6 respectively, brushes teeth daily each 1 time sooner or later, uses 2 grams of toothpaste every time, hold
It is 3 months continuous, it is brushed teeth using horizontal trembling method；Use preceding progress color spot index detection（Baseline）, carried out again after being used continuously 3 months
Color spot index detects, and compares the variation of the color spot index of subject before and after the dentifrice composition using the present embodiment 4 ~ 6.
Color spot index point-score, specific scoring rule are as follows：
0 point --- no color spot exists；
1 point --- color spot size is no more than the 1/3 of facing, and degree is slight color spot（Yellow or yellowish-brown）；
2 points --- color spot size is no more than the 2/3 of facing, and degree is moderate color spot（Moderate brown）；
3 points --- color spot size is more than the 2/3 of facing, and degree is severe color spot（Dark brown or black）；
Four, test result：
| Group | Baseline is averaged color spot index | Use average color spot index after 3 months | The reduced rate % of average color spot index based on baseline |
| 4 groups of embodiment | 1.89 | 0.61 | 67.7 |
| 5 groups of embodiment | 1.93 | 0.72 | 62.7 |
| 6 groups of embodiment | 1.95 | 0.77 | 60.5 |
Color spot index reduced rate=[（Color spot exponential average after 3 months is used using preceding color spot exponential average-）/ use
Preceding color spot exponential average] × 100%.
As seen from the above table, there is antibacterial, except the color spot that after the dentifrice composition of spot and whitening function, is averaged using the present invention
Index reduced rate is 60.5 ~ 67.7%, tooth-whitening significant effect.
Those skilled in the art do not depart from the present invention essence and spirit, can there are many deformation scheme realize the present invention,
The foregoing is merely preferably feasible embodiments of the invention, not thereby limit to the interest field of the present invention, all with this
Equivalent structure made by description of the invention changes, and is both contained within the interest field of the present invention.
Claims (7)
1. a kind of having antibacterial, except the dentifrice composition of spot and whitening function, including grinding agent, moisturizer, bonding agent, diester-type
Surfactant, complex enzyme, sweetener, fragrance, activated carbon, deionized water, which is characterized in that the complex enzyme be protease,
Lipase, amylase, lipoxygenase, glucose oxidase, phosphatidase, pectase, mannonase staphylococcus lysozyme and
The combination of lysozyme, the diester-type surfactant are with formula（1）The compound of shown structure：
（1）
Formula（1）In, R indicates the alkyl of different carbon atom numbers, the integer that the carbon atom number of R is 8 ~ 18；N is the unit of ethylene oxide ether
Number, the integer that n is 210 ~ 500.
2. there is antibacterial as described in claim 1, except the dentifrice composition of spot and whitening function, which is characterized in that the alkane
Base is straight chained alkyl or branched alkyl.
3. there is antibacterial as described in claim 1, except the dentifrice composition of spot and whitening function, which is characterized in that the n is
240 ~ 400 integer.
4. there is antibacterial as claimed in claim 3, except the dentifrice composition of spot and whitening function, which is characterized in that the n is
360 integer.
5. as claim 1 ~ 4 any one of them has antibacterial, except the dentifrice composition of spot and whitening function, feature exists
In described to there is antibacterial, except the dentifrice composition of spot and whitening function is made of the component of following weight percent：
Hydrated silica 20 ~ 35%；Aluminium hydroxide 20 ~ 35%；
Polypropylene glycol 4 ~ 7%；Glycerine 8 ~ 14%；
Sodium carboxymethylcellulose 0.3 ~ 0.5%；Xanthans 0.3 ~ 0.6%；
Carragheen 0.8 ~ 1.2%；Diester-type surfactant 1 ~ 3%；
Food flavor 1 ~ 1.5%；Saccharin sodium 0.18 ~ 0.28%；
Proteinase-10 .03 ~ 0.08%；Lipase 0.01 ~ 0.03%；
Amylase 0.01 ~ 0.03%；Lipoxygenase 0.1 ~ 0.5%；
Glucose oxidase 0.1 ~ 0.5%；Phosphide enzyme 0.01 ~ 0.04%；
Pectase 0.01 ~ 0.03%；Mannase 0.01 ~ 0.03%
Staphylococcus lysozyme 0.01 ~ 0.04%；Lysozyme 0.02 ~ 0.05%；
Activated carbon 5 ~ 10%；Deionized water 12 ~ 20%.
6. there is antibacterial as claimed in claim 5, except the dentifrice composition of spot and whitening function, which is characterized in that the tool
It is made of the component of following weight percent by antibacterial, except the dentifrice composition of spot and whitening function：
Hydrated silica 24 ~ 32%；Aluminium hydroxide 25 ~ 30%；
Polypropylene glycol 4 ~ 7%；Glycerine 10 ~ 12%；
Sodium carboxymethylcellulose 0.45 ~ 0.5%；Xanthans 0.3 ~ 0.45%；
Carragheen 0.8 ~ 1%；Diester-type surfactant 1 ~ 2%；
Food flavor 1.3 ~ 1.5%；Saccharin sodium 0.18 ~ 0.2%；
Proteinase-10 .06 ~ 0.08%；Lipase 0.015 ~ 0.025%；
Amylase 0.01 ~ 0.02%；Lipoxygenase 0.3 ~ 0.5%；
Glucose oxidase 0.3 ~ 0.5%；Phosphide enzyme 0.01 ~ 0.02%；
Pectase 0.01 ~ 0.02%；Mannase 0.01 ~ 0.02%；
Staphylococcus lysozyme 0.03 ~ 0.04%；Lysozyme 0.04 ~ 0.05%；
Activated carbon 6 ~ 8%；Deionized water 12.365 ~ 17.895%.
7. there is antibacterial as claimed in claim 6, except the dentifrice composition of spot and whitening function, which is characterized in that the tool
It is made of the component of following weight percent by antibacterial, except the dentifrice composition of spot and whitening function：
Hydrated silica 28%；Aluminium hydroxide 28%；
Polypropylene glycol 5%；Glycerine 10%；
Sodium carboxymethylcellulose 0.5%；Xanthans 0.4%；
Carragheen 0.8%；Diester-type surfactant 1.5%；
Food flavor 1.5%；Saccharin sodium 0.2%；
Proteinase-10 .08%；Lipase 0.02%；
Amylase 0.01%；Lipoxygenase 0.5%；
Glucose oxidase 0.4%；Phosphatidase 0.02%；
Pectase 0.01%；Mannase 0.01%；
Staphylococcus lysozyme 0.04%；Lysozyme 0.05%；
Activated carbon 7%；Deionized water 15.96%.
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| CN111000747B (en) * | 2018-12-31 | 2021-06-15 | 美釉(西安)生物技术有限公司 | Mineralized material for preventing enamel demineralization and application thereof |
| CN110368327A (en) * | 2019-08-14 | 2019-10-25 | 广州益凡医疗器械有限公司 | A kind of plaque removes gel and preparation method thereof |
| CN112190499B (en) * | 2020-11-12 | 2022-03-01 | 好易康生物科技(广州)有限公司 | Lysozyme oral care product for whitening teeth |
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| CN101085420A (en) * | 2006-06-06 | 2007-12-12 | 杨关雨 | Method of preparing nonionic surfactant o-benzenedicarboxylic acid polyethylene glycol ester |
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