CN1267081C - Toothpaste composition - Google Patents

Abstract

To provide a toothpaste composition having an excellent external appearance (texture when kneaded) and intraoral dispersibility. This toothpaste composition contains (A) 1.0-50 wt.% of thickening agents in which 1.0-5.0 wt.% of polyethylene glycol having an average molecular weight of 100-600 is contained, (B) 0.4-0.8 wt.% of xanthan gum as a binder, and (C) 2.0-3.5 wt% of sodium lauryl sulfate as a surfactant.

Description

Dentifrice composition

Technical field

The present invention relates to a kind of dentifrice composition with interior dispersibility of mouth of paste good appearance and excellence.

Background technology

With regard to traditional dentifrice composition with dispersibility in excellent mouthful, several technology have been proposed, comprise that a kind of preparation can discharge the powder binder of bivalence or polyvalent metal ion and the technology (the Japan Patent spy opens clear 61-15826) of the binding agent be made up of crosslinkable polyacrylic acid or its salt and xanthan gum, a kind of with xanthan gum and polyacrylate with specific blend than mixing the technology of using (Japanese patent laid-open 10-17445), with a kind of with silica abrasive, mix the binding agent that uses xanthan gum and sodium polyacrylate, wetting agent, water, the fluorine compounds preparation is so that have specific viscosity number and the technology of shear stress values (Japanese patent laid-open 10-45549).

Although these dentifrice compositions have dispersibility in the excellent mouth, still are a blank in the improvement aspect the outward appearance (perhaps paste outward appearance).Therefore, need to develop a kind of more dentifrice composition of excellent quality that has always.

Summary of the invention

The present invention finishes under these environment of this area, and the purpose of this invention is to provide a kind of dentifrice composition that has excellent paste outward appearance and have dispersibility in the excellent mouth.

To achieve these goals, we further investigate, the result unexpectedly finds, in the dentifrice composition that contains 1.0-50% (all is by weight) wetting agent when whenever this paper and back thereof occur, when mean molecule quantity is that the Polyethylene Glycol of 100-600 is as wetting agent, xanthan gum and polyacrylic acid or its salt are as binding agent, and sodium lauryl sulphate is as surfactant, they are with specific blend during than mixed preparing, and resulting composition can decompose in the oral cavity or separately and highly foaming fast.In addition, said composition has slick surface texturisation, excellent outward appearance, and have dispersibility in the excellent mouth.The present invention is based on that top discovery finishes.

More particularly, the invention is intended to provide a kind of dentifrice composition, it comprises:

(A) wetting agent of 1.0-50% is the Polyethylene Glycol of 100-600 in the mean molecule quantity that the gross weight of compositions contains 1.0-5.0% wherein;

(B) polyacrylic acid of the xanthan gum of 0.4-0.8% and 0.4-1.0% or its salt are as binding agent; With

(C) sodium lauryl sulphate of 2.0-3.5% is as surfactant.

Preferred forms of the present invention

Dentifrice composition of the present invention comprises that (A) is that the Polyethylene Glycol, (B) of 100-600 is as the xanthan gum of binding agent and polyacrylic acid or its salt with (C) as the sodium lauryl sulphate of surfactant as the mean molecule quantity of wetting agent.

In dentifrice composition of the present invention, based on the total amount of compositions, the total amount of wetting agent (being that mean molecule quantity is the total amount of the wetting agent of the Polyethylene Glycol of 100-600 and other type) should be at 1.0-50%, in the preferred 20-30% scope.If should amount less, the paste outward appearance be just poor, and relatively largely will reduce a mouthful interior dispersibility.

In practice of the present invention, should have 100-600 with the wetting agent prepared polyethylene glycol, the mean molecule quantity of preferred 300-400, and based on the total amount of compositions, its amount is 1.0-5.0%, preferably 2.0-4.0.If the amount of being somebody's turn to do is less, gained paste outward appearance is just poor, and relatively large owing to not guaranteeing that therefore Stability of toothpaste is disadvantageous.

On the other hand, be with regard to the wetting agent the Polyethylene Glycol of 100-600 except mean molecule quantity just, can use in sorbitol, glycerol, ethylene glycol, propylene glycol, 1,3 butylene glycol, polypropylene glycol, xylitol, maltose alcohol, the lactose etc. one or more.

Based on the total amount of compositions, the amount of the xanthan gum that uses as a kind of adhesive component is 0.4-0.8%, preferred 0.5-0.7%.If the amount of being somebody's turn to do is less, Stability of toothpaste can not be guaranteed.Relatively largely will cause a mouthful interior bad dispersibility.

Based on the total amount of compositions, the amount of polyacrylic acid or its salt is 0.4-1.0%, preferred 0.6-0.8%.Cause a mouthful interior bad dispersibility in a small amount, and relatively largely can not set up Stability of toothpaste.

Based on the total amount of compositions, the sodium lauryl sulphate that uses as surfactant is with 2.0-3.5%, and the amount of preferred 2.5-3.0% is used.Cause a mouthful interior bad dispersibility in a small amount, and relatively largely can not set up Stability of toothpaste.

Except said components, dentifrice composition of the present invention can also comprise, other the suitable component that is usually used in this purpose and prepares by conventional methods.As mentioned above, other component can be usually used in dentifrice composition, and can prepare in the scope of the amount of not overslaugh effect of the present invention.Can also use binding agent and surfactant and grinding agent, sweeting agent, flavoring agent, antiseptic and other various active components except necessary component.

For example, with regard to grinding agent, can use the synthetic resin of one or more calcium hydrogen phosphate anhydride, dicalcium phosphate dihydrate, tertiary calcium phosphate (calcium tertiary phosphate), calcium carbonate, calcium pyrophosphate, aluminium hydroxide, silicic acid anhydride, aluminium silicate, calcium sulfate, bentonite, Zirconium orthosilicate., polymethyl methacrylate and other type.If any, the amount of grinding agent is 10-50%, preferred 20-30%.

With regard to binding agent, can use one or more cellulose derivative such as carrageenin, sodium carboxymethyl cellulose, methylcellulose, hydroxyethyl-cellulose etc., the propylene glycol ester of alginate derivatives such as sodium alginate, alginic acid etc., natural gum is as gellan gum, tragacanth gum, karaya etc., composite adhesives such as polyvinyl alcohol and inorganic bond such as silica gel, Veegum ^, Laponite ^Deng.

With regard to surfactant, can use anion surfactant, non-ionic surface active agent and amphoteric surfactant.

With regard to anion surfactant; can use the alkyl sodium sulfate except sodium lauryl sulphate, for example the N-acyl glutamate of sodium tetradecyl sulfate, N-acyl group sodium sarcosinate such as N-12 carbonic acyl radical sodium sarcosinates, N-myristoyl sodium sarcosinate etc., dodecylbenzene sodium sulfonate, hydrogenated coconut fatty acid, single glycerol sulfate mono sodium, dodecyl sulfoacetic acid sodium, for example N-palmityl sodium glutamate, N-methyl-N acyl methyltaurin sodium, N-methyl-N-acyl group Sodium L-alaninate, alpha-olefin sodium sulfonate etc.

With regard to non-ionic surface active agent; can use for example sucrose fatty acid ester; fatty ester of maltose; the sugar fatty acid esters of milk sugar fats acid esters etc.; maltitol fatty acid ester for example; the sugar alcohol fatty acid esters of lactose fatty acid ester etc.; polyoxyethylenesorbitan monolaurate for example; the polyoxyethylene sorbitan aliphatic ester class of polyoxyethylene sorbitan monostearate etc.; the polyoxyethylene fatty acid ester class of polyoxyethylene hydrogenated Oleum Ricini for example; lauroyl list-or diglycollic amide for example; myristoyl is single-or the single or diglycollic amide class of fatty acid of diglycollic amide etc., the sorbitan aliphatic ester class; polyoxyethylene higher alcohol ethers; poloxalkol; polyoxyethylene polyoxypropylene fatty acid ester etc.

With regard to flavoring agent, can be used alone or in combination for example following flavoring agent: menthol, anethole, carvone, acetaminol, limonene, Decanol, citronellol, alpha-terpineol, linalool, ethyl linalool, vanillin, thymol, Oleum menthae, spearmint oil, wintergreen oil, Oleum Caryophylli, Oleum Eucalypti etc.

With regard to sweeting agent, can use saccharin sodium, stevioside, glycyrrhizic acid dipotassium, perillartine, thaumatin etc.

With regard to other active component, can use one or more to comprise following component: for example enzyme of the fluoride of sodium fluoride, sodium monofluorophosphate etc., for example glucanase, mutanase (mutanase), lysozyme, amylase, protease, lyases etc., tranexamic acid, episilon amino caproic acid, glycyrrhizic acid dicalcium, glycyrrhizic acid, bisabolol, chlorophyll, sodium chloride, water-soluble inorganic phosphate cpd, isopropyl methyl phenol (thymol and isothymol), triclosan, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride etc.

In practice of the present invention, preferably use antiinflammatory and/or antibacterial as active component.In this case, the antiinflammatory antifibrinolysin of tranexamic acid, episilon amino caproic acid etc. for example preferably.The example of antibacterial comprises isopropyl methyl phenol, triclosan, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride etc.When using, thereby these active components can be distributed to fast and show its effect in the mouth effectively.It should be noted that this antiinflammatory and antibacterial use and the 0.01-0.1% that respectively does for oneself usually with effective dose.

Dentifrice composition of the present invention has good paste outward appearance and mouthful interior excellent dispersion.

Embodiment

More specifically describe the present invention by embodiment, yet they should not be construed as limitation of the present invention.The comparative example has also been described.In these embodiments, percentage ratio all by weight.

Comparative example 1-3 and embodiment 1-6

Preparation has the dentifrice composition of prescription shown in the following table 1 and estimates dispersibility in paste outward appearance and the mouth according to following method by conventional methods.The results are shown in table 1.

(1) paste outward appearance

Be loaded on each sample in the container that diameter is 5mm and on a toothbrush coating about 1g, then estimate its outward appearance by visual observation according to following standard.

Zero: good,

△: poor slightly,

*: poor

(2) dispersibility

Each sample application of about 1g to toothbrush, is then brushed teeth, routinely according to the dispersibility of following standard sensory evaluation toothpaste.

Zero: good dispersion,

△: dispersibility is poor slightly,

*: bad dispersibility

Table 1

Form (%)	The comparative example			Embodiment
										1	2	3	1	2	3	4	5	6
	PEG400	-	-	4	3	3.5	2.5	4	2										4.5
Propylene glycol										3	2.5	-	-	-	-	-	-
	Xanthan gum	0.4	0.6	0.6	0.5	0.6	0.4	0.5	0.6										0.4
Sodium polyacrylate										0.7	0.6	-	0.6	0.5	0.7	0.6	0.8	0.9
	Carrageenin	-	0.2	0.8	-	0.3	-	0.1	-										-
Sodium alginate										-	-	-	-	-	-	-	0.2
	Sodium carboxymethyl cellulose	-	-	-	-	-	0.1	-	-										0.1
Sodium lauryl sulphate										1.6	2.5	1.2	2.6	2.2	2.8	2.6	2.9	2.7
	Tranexamic acid	0.05	-	-	0.05	0.05	-	0.05	-										-
Episilon amino caproic acid										-	0.03	0.05	-	-	0.01		-	0.01
	Triclosan	-	-	-	-	-	-	0.02	-										-
Isopropyl methyl phenol										-	-	-	-	-	-	-	0.05	-
	Cetylpyridinium chloride	-	-	-	-	-	-	0.03	-										-
Benzalkonii Chloridum										-	-	-	-	-		-	0.07	-
	Benzethonium chloride	-	-	-	-	-	-	-	0.01										-
Silicic acid anhydride										20	-	-	15	-	-	20	-	-
	Aluminium hydroxide	-	40	-	-	30	-	-	45
Calcium carbonate										-	-	30	-	-	40	-	-	30
	Glycerol	30	-	25	20	-	-	30	30										-
Sorbitol										-	25		-	25	23	-	-	25
	Saccharin sodium	0.25	0.12	0.1	0.15	0.12	0.13	0.16	0.12										0.13
Flavoring agent										1.1	1.5	1.3	1.1	1.2	1.4	1.1	1.2	1.2
	Purify waste water	Surplus	Surplus	Surplus	Surplus	Surplus	Surplus	Surplus	Surplus										Surplus
Summation										100	100	100	100	100	100	100	100	100
	The paste outward appearance	×	×	○	○	○	○	○	○										○
Dispersibility										△	○	△	○	○	○	○	○	○

The following dentifrice composition of forming of preparation is also estimated, and proves that all compositionss are smooth and have a dispersibility in the excellent mouth aspect the paste outward appearance.

Embodiment 7

Polyethylene Glycol (molecular weight: 200)

3％

Xanthans Sodium Polyacrylate lauryl sodium sulfate flavouring agent tranexamic acid taurine 85% glycerine abrasive silica saccharin sodium is purified waste water	0.6 0.8 2.5 1 0.05 0.3 25 20 0.2 surpluses
		Summation	100％

Embodiment 8

Polyethylene glycol (molecular weight: 200) purify waste water by xanthans Sodium Polyacrylate lauryl sodium sulfate tranexamic acid flavouring agent 70% D-sorbite aluminium hydroxide saccharin sodium	4% 0.4 0.7 3.0 0.05 1 30 18 0.15 surplus
		Summation	100％

Embodiment 9

Polyethylene Glycol (molecular weight: 600) xanthan gum sodium polyacrylate

4％ 0.5 0.6

Lauryl sodium sulfate EACA sodium pyrophosphate flavouring agent 70% D-sorbite calcium carbonate saccharin sodium is purified waste water	3.3 0.03 51 35 25 0.2 surplus
		Summation	100％

Embodiment 10

Polyethylene glycol (molecular weight: 400) purify waste water by xanthans Sodium Polyacrylate lauryl sodium sulfate EACA sodium acid carbonate sodium phosphate trimer flavouring agent 70% D-sorbite calcium monohydrogen phosphate saccharin sodium	2% 0.4 0.8 2.4 0.05 361 30 18 0.15 surplus
		Summation	100％

Embodiment 11

Polyethylene Glycol (molecular weight: 300) xanthan gum sodium polyacrylate

2.5％ 0.5 0.8

Lauryl sodium sulfate tranexamic acid flavouring agent sodium fluoride 85% glycerine calcium carbonate saccharin sodium is purified waste water	2.5 0.05 0.8 0.2 30 20 0.15 surplus
		Summation	100％

Embodiment 12

Polyethylene glycol (molecular weight: 400) purify waste water by xanthans Sodium Polyacrylate lauryl sodium sulfate EACA cetylpyridinium chloride sodium fluoride flavouring agent 70% D-sorbite abrasive silica saccharin sodium	2.5% 0.6 0.5 2.5 0.03 0.03 0.2 1 40 20 0.2 surplus
		Summation	100％

Embodiment 13

Polyethylene Glycol (molecular weight: 500) xanthan gum sodium polyacrylate

3％ 0.7 0.7

Lauryl sodium sulfate tranexamic acid BZK sodium monofluorophosphate flavouring agent 70% D-sorbite aluminium hydroxide saccharin sodium is purified waste water	3 0.05 0.02 0.7 1.2 30 30 0.2 surpluses
		Summation	100％

Embodiment 14

Polyethylene glycol (molecular weight: 300) purify waste water by xanthans Sodium Polyacrylate lauryl sodium sulfate benzethonium chloride flavouring agent 70% D-sorbite aluminium hydroxide saccharin sodium	4% 0.7 0.6 3.2 0.02 1.2 40 20 0.2 surplus
		Summation	100％

Claims (3)

1, a kind of dentifrice composition, contain:

(A) wetting agent of 1.0-50% is the Polyethylene Glycol of 100-600 in the mean molecule quantity that the gross weight of compositions contains 1.0-5.0% wherein;

(B) polyacrylic acid of the xanthan gum of 0.4-0.8% and 0.4-1.0% or its salt are as binding agent; With

(C) sodium lauryl sulphate of 2.0-3.5% is as surfactant.

2, dentifrice composition as claimed in claim 1 also contains at least a active component that is selected from antiinflammatory and antibacterial.

3, dentifrice composition as claimed in claim 2, wherein said antiinflammatory is an antifibrinolysin.