CN105769600B - Dentifrice composition with potent antibacterial function - Google Patents
Dentifrice composition with potent antibacterial function Download PDFInfo
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- CN105769600B CN105769600B CN201410803101.2A CN201410803101A CN105769600B CN 105769600 B CN105769600 B CN 105769600B CN 201410803101 A CN201410803101 A CN 201410803101A CN 105769600 B CN105769600 B CN 105769600B
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- dentifrice composition
- diester
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- lysozyme
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- 239000000203 mixture Substances 0.000 title claims abstract description 41
- 239000000551 dentifrice Substances 0.000 title claims abstract description 32
- 230000003389 potentiating effect Effects 0.000 title claims abstract description 30
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 28
- 102000004190 Enzymes Human genes 0.000 claims abstract description 34
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- 239000004094 surface-active agent Substances 0.000 claims abstract description 33
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000008367 deionised water Substances 0.000 claims abstract description 12
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 12
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 6
- 239000004909 Moisturizer Substances 0.000 claims abstract description 3
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- 239000003205 fragrance Substances 0.000 claims abstract description 3
- 238000000227 grinding Methods 0.000 claims abstract description 3
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- 239000003765 sweetening agent Substances 0.000 claims abstract description 3
- 102000016943 Muramidase Human genes 0.000 claims description 36
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- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
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Abstract
The invention discloses a kind of dentifrice compositions with potent antibacterial function, including grinding agent, moisturizer, bonding agent, diester-type surfactant, complex enzyme, sweetener, fragrance, mannatide, deionized water.Extracellular polymeric, cell wall and the cell membrane of plaque flora secretion are decomposed in biological enzyme collaboration, hydroperoxides and hydrogen peroxide are generated while decomposing, oxidation neutralization is carried out to high-caliber sulfydryl in Dental plaque biofilm by hydroperoxides and hydrogen peroxide, and oxidation killing is carried out to bacterial cell, reduce the resistance of its exogenous biology enzyme effect of bacterial cell, meanwhile the polysaccharide chains of the catabolite cut-out bacteria cell wall of mannatide, absorption pathogen keep pathogen hungry and dead；Diester-type surfactant has potent cleaning and dirt-removing power, can effectively remove Dental plaque biofilm and broken thalline, and after subject's use, the slip that average colony forms unit is 84.6 ~ 88.3%, and amount of bacteria substantially reduces.
Description
Technical field
The invention belongs to daily necessities technical field, especially a kind of enzyme-containing toothpaste group with potent antibacterial function
Close object.
Background technology
Dental plaque biofilm is the ecosystem that varied flora on facing or in oral pocket is constituted.Bacterium is raw inside
Long, development and decline.Its complicated structure enables it to forgive the bacterium to oxygen difference sensibility, these bacteriums are embedded in by more
In the matrix of sugar, protein and minerals composition.The metabolic activity of bacterium wherein, affects between bacterium and host or bacterium
Dynamic equilibrium between Pseudomonas.Dental plaque biofilm is present in the surface of nearly all tooth, and is firmly stuck to tooth table
Face, or even be also difficult to be removed by violent activity of brushing teeth.After forming plaque on tooth, if not in time and effectively
It removes, plaque will constantly expand and eventually lead to the periodontosis and saprodontia and tooth of gingivitis, periodontitis and other forms
Calculus.The core of removal plaque is to remove the extracellular polymeric of microorganism secretion.The constituent of extracellular polymeric is relatively more
Sample, component is because the difference of derived microbial is also variant, but generally speaking, extracellular polymeric is mainly by protein, polysaccharide, core
The compositions such as acid, uronic acid, lipid, humic acid, amino acid.Protein and polysaccharide are its main components, account for extracellular polymeric total amount
70 ~ 80%.Various biological enzyme are commonly used in the extracellular polymeric of removal microorganism, the effect of biological enzyme is to decompose extracellular polymer
Object, microorganism cell wall and cell membrane, to reach inhibit microorganism growth and its formed Dental plaque biofilm.However,
Oral microorganism itself can resist the decomposition of exogenous biological enzyme with secretase to degrade exogenous biological enzyme so that outer
The efficacy wanes of source property biological enzyme.In addition, high-caliber sulfydryl can neutralize oxygroup in Dental plaque biofilm, protection bacterial cell is exempted from
Oxidative damage, protection flora resist oral cavity harsh environment, bacterium are made to remain to retain in unsuitable condition.
Invention content
For the above-mentioned fact, make high-caliber sulfydryl in Dental plaque biofilm that bacterial cell be made to be subjected to oxidation damage after neutralizing again
Hinder to reduce the resistance of its exogenous biology enzyme effect, meanwhile, it adsorbs intraoral pathogen and keeps its starvation lethal, be more
For the new approaches of potent antibacterial.
In order to solve the above technical problems, the technical solution adopted by the present invention is：It provides a kind of with potent antibacterial function
Dentifrice composition, including grinding agent, moisturizer, bonding agent, diester-type surfactant, complex enzyme, sweetener, fragrance, go from
Sub- water and mannatide, the complex enzyme are protease, lipase, amylase, lipoxygenase, glucose oxidase, phosphorus
The combination of lipase, pectase, staphylococcus lysozyme and lysozyme, the diester-type surfactant are with formula（1）Shown knot
The compound of structure：
Formula（1）In, R indicates the alkyl of different carbon atom numbers, the integer that the carbon atom number of R is 8 ~ 18；N is ethylene oxide ether
Unit number, the integer that n is 210 ~ 500.
Preferably, the alkyl is straight chained alkyl or branched alkyl.Straight chained alkyl or branched alkyl make diester-type surface
Two carbochains of activating agent have good hydrophobicity, are conducive to remove broken thalline.
Preferably, the integer that the n is 240 ~ 400.For toothpaste, surfactant will have certain foaminess
Can, otherwise influence the cleaning action of toothpaste.When the unit number of the ethylene oxide ether of diester-type surfactant is 240 ~ 400, it can make
Diester-type surfactant has good foam performance, can guarantee the cleaning performance of toothpaste.
Most preferably, the integer that the n is 360.For toothpaste, the foam that surfactant generates should not be excessive,
Otherwise it influences to use.When the unit number of the ethylene oxide ether of diester-type surfactant is 360, diester-type surfactant is not only
Have foam performance, and bubble amt optimum.
Specifically, the dentifrice composition with potent antibacterial function is made of the component of following weight percent：
Hydrated silica 20 ~ 35%；Aluminium hydroxide 20 ~ 35%；
Polypropylene glycol 4 ~ 7%；Glycerine 8 ~ 14%；
Sodium carboxymethylcellulose 0.3 ~ 0.5%；Xanthans 0.3 ~ 0.6%；
Carragheen 0.8 ~ 1.2%；Diester-type surfactant 1 ~ 3%；
Food flavor 1 ~ 1.5%；Saccharin sodium 0.18 ~ 0.28%；
Proteinase-10 .1 ~ 0.5%；Lipase 0.1 ~ 0.5%；
Amylase 0.1 ~ 0.5%；Lipoxygenase 0.1 ~ 0.5%；
Glucose oxidase 0.1 ~ 0.5%；Phosphide enzyme 0.01 ~ 0.04%；
Staphylococcus lysozyme 0.01 ~ 0.04%；Lysozyme 0.02 ~ 0.05%；
Pectase 0.01 ~ 0.03%；Mannatide 1 ~ 10%；
Deionized water 12 ~ 20%.
Preferably, the dentifrice composition with potent antibacterial function is made of the component of following weight percent：
Hydrated silica 24 ~ 32%；Aluminium hydroxide 25 ~ 30%；
Polypropylene glycol 4 ~ 7%；Glycerine 10 ~ 12%；
Sodium carboxymethylcellulose 0.45 ~ 0.5%；Xanthans 0.3 ~ 0.45%；
Carragheen 0.8 ~ 1%；Diester-type surfactant 1 ~ 2%；
Food flavor 1.3 ~ 1.5%；Saccharin sodium 0.18 ~ 0.2%；
Proteinase-10 .3 ~ 0.5%；Lipase 0.3 ~ 0. 5%；
Amylase 0.3 ~ 0.5%；Lipoxygenase 0.3 ~ 0.5%；
Glucose oxidase 0.3 ~ 0.5%；Phosphide enzyme 0.01 ~ 0.02%；
Staphylococcus lysozyme 0.03 ~ 0.04%；Lysozyme 0.04 ~ 0.05%；
Pectase 0.01 ~ 0.02%；Mannatide 3 ~ 7%；
Deionized water 12.36 ~ 19.74%.
After subject is using the above-mentioned dentifrice composition with potent antibacterial function preferably combined, average colony forms list
The reduced rate of position is 84.6 ~ 85.2%, and amount of bacteria substantially reduces.
Most preferably, the dentifrice composition with potent antibacterial function is made of the component of following weight percent：
Hydrated silica 28%；Aluminium hydroxide 28%；
Polypropylene glycol 5%；Glycerine 10%；
Sodium carboxymethylcellulose 0.5%；Xanthans 0.4%；
Carragheen 0.8%；Diester-type surfactant 1.5%；
Food flavor 1.5%；Saccharin sodium 0.2%；
Proteinase-10 .4%；Lipase 0.4%；
Amylase 0.4%；Lipoxygenase 0.5%；
Glucose oxidase 0.4%；Phosphatidase 0.02%；
Staphylococcus lysozyme 0.04%；Lysozyme 0.05%；
Pectase 0.01%；Mannatide 5%；
Deionized water 16.88%.
After subject is using the above-mentioned most preferred dentifrice composition with potent antibacterial function, average colony forms unit
Reduced rate be 88.3%, amount of bacteria substantially reduces.
Various biological enzyme in the dentifrice composition with potent antibacterial function of the present invention play synergistic effect, wherein egg
White enzyme, lipase, amylase and pectase decompose the extracellular polymeric of plaque flora secretion, make to be hidden in extracellular polymeric
Microbial exposure comes out；Protease, lipase and amylase decompose mannatide jointly simultaneously, and mannatide is made to be degraded to
Basic polypeptide and manna oligosacchride, basic polypeptide cut off connection N-acetyl Portugal amine and N-acetylmuramic acid in bacteria cell wall
Polysaccharide chains make bacterium that the cracking of hyposmosis type occur, to kill bacterium.Manna oligosacchride can adsorb pathogen, and pathogen is not
Manna oligosacchride can be utilized, making pathogen, it is hungry and dead.Lipoxygenase decomposes residual fatty spot in the oral cavity and extracellular
Lipid in polymer simultaneously generates hydroperoxides；Glucose oxidase decomposes in desizing spot and extracellular polymeric in oral cavity
Carbohydrate and generate hydrogen peroxide, hydroperoxides and hydrogen peroxide can not only to high-caliber sulfydryl in Dental plaque biofilm into
Row oxidation neutralizes, and continues to carry out oxidation killing to bacterial cell after the neutralization, reduces bacterial cell its exogenous biology
The resistance of enzyme effect；Protease, lipase, amylase, pectase, staphylococcus lysozyme, lysozyme and phosphatidase decompose micro- again
The cell wall and cell membrane of biology；Two hydrophobic carbochains of diester-type surfactant are adsorbed broken by intermolecular active force
The phospholipid bilayer of bacterium, the phenyl ring of hydrophobic carbon chain link enhance the suction of hydrophobic carbochain and the phospholipid bilayer of broken bacterium
Attached ability, while diester-type surfactant has suitable foam performance again, reinforces the removing of broken thalline.
It is understood that potent antibacterial new approaches according to the present invention, other than toothpaste, in the matrix components of mouthwash
May include mannatide, by protease, lipase, amylase, lipoxygenase, glucose oxidase, phosphatidase, pectin
Enzyme, staphylococcus lysozyme, the complex enzyme of lysozyme composition and the diester-type surfactant；The matrix of oral spray at
Point in may include mannatide, by protease, lipase, amylase, lipoxygenase, glucose oxidase, phosphatidase,
Pectase, staphylococcus lysozyme, the complex enzyme of lysozyme composition and the diester-type surfactant；The base of cleaning agent for mouth cavity
May include mannatide in matter ingredient, by protease, lipase, amylase, lipoxygenase, glucose oxidase, phosphorus
Complex enzyme and the diester-type surfactant of lipase, pectase, staphylococcus lysozyme and lysozyme composition；Chewing gum
May include in matrix components mannatide and by protease, lipase, amylase, lipoxygenase, glucose oxidase,
The complex enzyme of phosphatidase, pectase, staphylococcus lysozyme, lysozyme composition.
The beneficial effects of the invention are as follows：For the bad situation of existing dentifrice composition antibacterial effect, the present invention has
In the dentifrice composition of potent antibacterial function biological enzyme collaboration decompose plaque flora secretion extracellular polymeric, cell wall and
Cell membrane generates hydroperoxides and hydrogen peroxide, by hydroperoxides and hydrogen peroxide to plaque while decomposing
High-caliber sulfydryl carries out oxidation neutralization in biomembrane, and carries out oxidation killing to bacterial cell, and reducing bacterial cell, it is external
The resistance of source property biology enzyme effect, meanwhile, the polysaccharide chains of the catabolite cut-out bacteria cell wall of mannatide adsorb cause of disease
Bacterium keeps pathogen hungry and dead；Diester-type surfactant has potent cleaning and dirt-removing power, can effectively remove plaque
Biomembrane and broken thalline, after subject's use, the slip that average colony forms unit is 84.6 ~ 88.3%, and amount of bacteria is notable
It reduces.
Specific implementation mode
The following describes the present invention in detail with reference to examples.
Embodiment 1
In the reaction kettle of the esterification for carrying condenser, water knockout drum at 10 liters, 5 kilograms of toluene, 4.48 kilograms of straight chains are sequentially added
Octyl phenol polyoxyethylene ether（Alkyl phenol polyoxyethylene ether, R=8, n=210）, 0.52 kilogram of phthalic anhydride, with 150 revs/min
The mixing speed of clock stirs 30 minutes, makes straight chain octyl phenol polyoxyethylene ether（Alkyl phenol polyoxyethylene ether, R=8, n=210）And neighbour
Phthalate anhydride is completely dissolved in toluene；0.05 kilogram of p-methyl benzenesulfonic acid is added, and with 150 revs/min of stirring speed
Degree stirring 10 minutes, Catalyzed by P-Toluenesulfonic Acid straight chain octyl phenol polyoxy ether（Alkyl phenol polyoxyethylene ether, R=8, n=210）With
Esterification occurs for phthalic anhydride；110 DEG C are warming up to, and small with the stirring of 150 revs/min of mixing speed, back flow reaction 4
When；The water in water knockout drum is finally removed, toluene is extracted using vacuum pump, is cooled to room temperature, obtain diester-type surfactant, it should
Diester-type surfactant structure is as follows：
（R=8）.
Embodiment 2
At 10 liters with condenser, water knockout drum reaction kettle of the esterification in, sequentially add 5 kilograms of toluene, 4.92 kilograms it is different pungent
Base phenol polyethenoxy ether（Alkyl phenol polyoxyethylene ether, R=12, n=500）, 0.08 kilogram of phthalic anhydride, with 150 revs/min
Mixing speed stir 30 minutes, make isooctyl phenol polyethoxylate（Alkyl phenol polyoxyethylene ether, R=12, n=500）With adjacent benzene
Dicarboxylic acid anhydride is completely dissolved in toluene；0.003 kg of phosphoric acid is added, and 10 points are stirred with 150 revs/min of mixing speed
Clock, phosphoric acid catalyzed isooctylphenol polyoxy ether（Alkyl phenol polyoxyethylene ether, R=12, n=500）Ester occurs with phthalic anhydride
Change reaction；It is warming up to 110 DEG C, and with the stirring of 150 revs/min of mixing speed, back flow reaction 4 hours；Finally remove water knockout drum
In water, extract toluene using vacuum pump, be cooled to room temperature, obtain diester-type surfactant, the diester-type surfactant
Structure is as follows：
（R=12）.
Embodiment 3
In the reaction kettle of the esterification for carrying condenser, water knockout drum at 10 liters, 5 kilograms of toluene, 4.85 kilograms of straight chains are sequentially added
Dodecyl phenol polyethenoxy ether（Alkyl phenol polyoxyethylene ether, R=18, n=360）, 0.15 kilogram of phthalic anhydride, with 150
Rev/min mixing speed stir 30 minutes, make straight chain dodecyl phenol polyethenoxy ether（Alkyl phenol polyoxyethylene ether, R=18,
n=360）It is completely dissolved in toluene with phthalic anhydride；It adds 0.02 kilogram of benzene sulfonic acid, and is stirred with 150 revs/min
It mixes speed to stir 10 minutes, benzene sulfonic acid is catalyzed straight chain dodecylphenol polyoxy ether（Alkyl phenol polyoxyethylene ether, R=18, n=
360）Esterification occurs with phthalic anhydride；110 DEG C are warming up to, and with the stirring of 150 revs/min of mixing speed, reflux
Reaction 4 hours；The water in water knockout drum is finally removed, toluene is extracted using vacuum pump, is cooled to room temperature, obtains the work of diester-type surface
Property agent, the diester-type surfactant structure are as follows：
（R=18）.
Embodiment 4
Dentifrice composition with potent antibacterial function consists of the following compositions（Weight percent）：
Hydrated silica 28%；Aluminium hydroxide 28%；
Polypropylene glycol 5%；Glycerine 10%；
Sodium carboxymethylcellulose 0.5%；Xanthans 0.4%；
Carragheen 0.8%；3 diester-type surfactant 1.5% of embodiment；
Food flavor 1.5%；Saccharin sodium 0.2%；
Proteinase-10 .4%；Lipase 0.4%；
Amylase 0.4%；Lipoxygenase 0.5%；
Glucose oxidase 0.4%；Phosphatidase 0.02%；
Staphylococcus lysozyme 0.04%；Lysozyme 0.05%；
Pectase 0.01%；Mannatide 5%；
Deionized water 16.88%.
Preparation method is as follows：
One, complex enzyme is prepared
By above-mentioned weight percent, by protease, lipase, amylase, lipoxygenase, glucose oxidase, phosphatide
Enzyme, pectase, staphylococcus lysozyme and lysozyme are uniformly mixed；
Two, glue
By above-mentioned weight percent, by hydrated silica, aluminium hydroxide, polypropylene glycol, glycerine, sodium carboxymethylcellulose, Huang
Virgin rubber, carragheen, diester-type surfactant, food flavor, mannatide, complex enzyme and deionization made from embodiment 3
Water uniform stirring, is made colloid；
Three, it mediates
By above-mentioned weight percent, saccharin sodium is added in colloid, stir evenly and deaerates, lotion is made.
Embodiment 5
Dentifrice composition with potent antibacterial function consists of the following compositions（Weight percent）：
Hydrated silica 24%；Aluminium hydroxide 30%；
Polypropylene glycol 4%；Glycerine 12%；
Sodium carboxymethylcellulose 0.45%；Xanthans 0.3%；
Carragheen 0.8%；Diester-type surfactant 2% made from embodiment 1；
Food flavor 1.3%；Saccharin sodium 0.2%；
Proteinase-10 .3%；Lipase 0. 5%；
Amylase 0.3%；Lipoxygenase 0.5%；
Glucose oxidase 0.5%；Phosphide enzyme 0.02%；
Staphylococcus lysozyme 0.03%；Lysozyme 0.05%；
Pectase 0.01%；Mannatide 3%；
Deionized water 19.74%.
Preparation method is the same as embodiment 4.
Embodiment 6
Dentifrice composition with potent antibacterial function consists of the following compositions（Weight percent）：
Hydrated silica 32%；Aluminium hydroxide 25%；
Polypropylene glycol 7%；Glycerine 10%；
Sodium carboxymethylcellulose 0.5%；Xanthans 0.45%；
Carragheen 1%；Diester-type surfactant 1% made from embodiment 2；
Food flavor 1.5%；Saccharin sodium 0.18%；
Proteinase-10 .5%；Lipase 0.3%；
Amylase 0.5%；Lipoxygenase 0.3%；
Glucose oxidase 0.3%；Phosphide enzyme 0.01%；
Staphylococcus lysozyme 0.04%；Lysozyme 0.04%；
Pectase 0.02%；Mannatide 7%；
Deionized water 12.36%.
Preparation method is the same as embodiment 4.
Embodiment 7
The antibacterial functions of the dentifrice composition of the present invention
One, material is tried out：The dentifrice composition of embodiment 4 ~ 6 and the dentifrice composition of control group.
Two, object is tried out：40 subjects.
Three, test method：
Experimental group：30 subjects are randomly divided into 3 groups, respectively 6 groups of 4 groups of embodiment, 5 groups of embodiment and embodiment,
Every group 10；Subject aspirates in tongue back side to collect bacterium, then by the sample blood agar of collection before experiment
Culture medium is cultivated under 37 DEG C of anaerobic condition, after 72 hours, calculates average bacteriological Colony Forming Unit（Baseline）, then
Subject uses the dentifrice composition of the present embodiment 4 ~ 6 respectively, brushes teeth daily each 1 time sooner or later, uses 2 grams of toothpaste every time, continue 3
It a month, is brushed teeth using horizontal trembling method；After 3 months, subject aspirates in the tongue back other side to collect bacterium, then will receive
The sample of collection is cultivated with blood agar culture-medium under 37 DEG C of anaerobic condition, after 72 hours, calculates average bacteriological bacterium colony shape
At unit, the average colony for comparing subject before and after the dentifrice composition using the present embodiment 4 ~ 6 forms the variation of unit results.
Control group：10 subjects, the same experimental group of method.The toothpaste of control group closes object（Without mannatide）Component
It is as follows：
Hydrated silica 28%；Aluminium hydroxide 28%；
Polypropylene glycol 5%；Glycerine 10%；
Sodium carboxymethylcellulose 0.5%；Xanthans 0.4%；
Carragheen 0.8%；3 diester-type surfactant 1.5% of embodiment；
Food flavor 1.5%；Saccharin sodium 0.2%；
Proteinase-10 .4%；Lipase 0.4%；
Amylase 0.4%；Lipoxygenase 0.5%；
Glucose oxidase 0.4%；Phosphatidase 0.02%；
Staphylococcus lysozyme 0.04%；Lysozyme 0.05%；
Pectase 0.01%；Deionized water 21.88%.
Four, test result：
| Group | Baseline is averaged CFU | Use average CFU after 3 months | The reduced rate % of average CFU based on baseline |
| 4 groups of embodiment | 9.4×105 | 1.1×105 | 88.3 |
| 5 groups of embodiment | 8.8×105 | 1.3×105 | 85.2 |
| 6 groups of embodiment | 7.8×105 | 1.2×105 | 84.6 |
| Control group | 8.3×105 | 2.3×105 | 72.3 |
CFU=Colony Forming Unit
Average CFU reduced rates=[（The baseline CFU- that is averaged uses CFU average values after 3 months）/ baseline is averaged CFU] × 100%.
As seen from the above table, after using the dentifrice composition with potent antibacterial function of the present invention, average colony forms list
The reduced rate of position is 84.6 ~ 88.3%, and amount of bacteria substantially reduces；And the dentifrice composition average colony shape without mannatide
Although the reduced rate at unit also reaches 72.3%, still there is certain gap compared with experimental group.
Those skilled in the art do not depart from the present invention essence and spirit, can there are many deformation scheme realize the present invention,
The foregoing is merely preferably feasible embodiments of the invention, not thereby limit to the interest field of the present invention, all with this
Equivalent structure made by description of the invention changes, and is both contained within the interest field of the present invention.
Claims (7)
1. a kind of dentifrice composition with potent antibacterial function, including grinding agent, moisturizer, bonding agent, the work of diester-type surface
Property agent, complex enzyme, sweetener, fragrance, deionized water, which is characterized in that further include mannatide, the complex enzyme be albumen
Enzyme, lipase, amylase, lipoxygenase, glucose oxidase, phosphatidase, pectase, staphylococcus lysozyme and lysozyme
Combination, the diester-type surfactant are with formula（1）The compound of shown structure：
Formula（1）In, R indicates the alkyl of different carbon atom numbers, the integer that the carbon atom number of R is 8 ~ 18；N is the unit of ethylene oxide ether
Number, the integer that n is 210 ~ 500.
2. the dentifrice composition with potent antibacterial function as described in claim 1, which is characterized in that the alkyl is straight chain
Alkyl or branched alkyl.
3. the dentifrice composition with potent antibacterial function as described in claim 1, which is characterized in that the n is 240 ~ 400
Integer.
4. as claimed in claim 3 with potent antibacterial function dentifrice composition, which is characterized in that the n be 360 it is whole
Number.
5. as claim 1 ~ 4 any one of them has the dentifrice composition of potent antibacterial function, which is characterized in that the tool
It is made of the component of following weight percent the dentifrice composition of potent antibacterial function：
Hydrated silica 20 ~ 35%；Aluminium hydroxide 20 ~ 35%；
Polypropylene glycol 4 ~ 7%；Glycerine 8 ~ 14%；
Sodium carboxymethylcellulose 0.3 ~ 0.5%；Xanthans 0.3 ~ 0.6%；
Carragheen 0.8 ~ 1.2%；Diester-type surfactant 1 ~ 3%；
Food flavor 1 ~ 1.5%；Saccharin sodium 0.18 ~ 0.28%；
Proteinase-10 .1 ~ 0.5%；Lipase 0.1 ~ 0.5%；
Amylase 0.1 ~ 0.5%；Lipoxygenase 0.1 ~ 0.5%；
Glucose oxidase 0.1 ~ 0.5%；Phosphide enzyme 0.01 ~ 0.04%；
Staphylococcus lysozyme 0.01 ~ 0.04%；Lysozyme 0.02 ~ 0.05%；
Pectase 0.01 ~ 0.03%；Mannatide 1 ~ 10%；
Deionized water 12 ~ 20%.
6. the dentifrice composition with potent antibacterial function as claimed in claim 5, which is characterized in that described that there is potent resist
The dentifrice composition of bacterium function is made of the component of following weight percent：
Hydrated silica 24 ~ 32%；Aluminium hydroxide 25 ~ 30%；
Polypropylene glycol 4 ~ 7%；Glycerine 10 ~ 12%；
Sodium carboxymethylcellulose 0.45 ~ 0.5%；Xanthans 0.3 ~ 0.45%；
Carragheen 0.8 ~ 1%；Diester-type surfactant 1 ~ 2%；
Food flavor 1.3 ~ 1.5%；Saccharin sodium 0.18 ~ 0.2%；
Proteinase-10 .3 ~ 0.5%；Lipase 0.3 ~ 0. 5%；
Amylase 0.3 ~ 0.5%；Lipoxygenase 0.3 ~ 0.5%；
Glucose oxidase 0.3 ~ 0.5%；Phosphide enzyme 0.01 ~ 0.02%；
Staphylococcus lysozyme 0.03 ~ 0.04%；Lysozyme 0.04 ~ 0.05%；
Pectase 0.01 ~ 0.02%；Mannatide 3 ~ 7%；
Deionized water 12.36 ~ 19.74%.
7. the dentifrice composition with potent antibacterial function as claimed in claim 6, which is characterized in that described that there is potent resist
The dentifrice composition of bacterium function is made of the component of following weight percent：
Hydrated silica 28%；Aluminium hydroxide 28%；
Polypropylene glycol 5%；Glycerine 10%；
Sodium carboxymethylcellulose 0.5%；Xanthans 0.4%；
Carragheen 0.8%；Diester-type surfactant 1.5%；
Food flavor 1.5%；Saccharin sodium 0.2%；
Proteinase-10 .4%；Lipase 0.4%；
Amylase 0.4%；Lipoxygenase 0.5%；
Glucose oxidase 0.4%；Phosphatidase 0.02%；
Staphylococcus lysozyme 0.04%；Lysozyme 0.05%；
Pectase 0.01%；Mannatide 5%；
Deionized water 16.88%.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1437927A (en) * | 2002-02-15 | 2003-08-27 | 狮王株式会社 | Toothpaste composition |
| CN1883445A (en) * | 2006-05-26 | 2006-12-27 | 清华大学 | Multifunctional enzyme-supplemented colorful toothpaste and preparation method thereof |
| CN101085420A (en) * | 2006-06-06 | 2007-12-12 | 杨关雨 | Method of preparing nonionic surfactant o-benzenedicarboxylic acid polyethylene glycol ester |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1437927A (en) * | 2002-02-15 | 2003-08-27 | 狮王株式会社 | Toothpaste composition |
| CN1883445A (en) * | 2006-05-26 | 2006-12-27 | 清华大学 | Multifunctional enzyme-supplemented colorful toothpaste and preparation method thereof |
| CN101085420A (en) * | 2006-06-06 | 2007-12-12 | 杨关雨 | Method of preparing nonionic surfactant o-benzenedicarboxylic acid polyethylene glycol ester |
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| Title |
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| 甘露聚糖肽生物活性的研究进展;宋刚等;《化学与生物工程》;20070425;第24卷(第4期);第14-16页. * |
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Effective date of registration: 20170613 Address after: 247099 Shuanglong Road 1, Chizhou economic and Technological Development Zone, Anhui, China Applicant after: ANHUI LEVEKING BIOTECHNOLOGY Co.,Ltd. Address before: 518000 Guangdong city of Shenzhen province Nanshan District Xili town before light industrial village 21 Building 8 floor Applicant before: SHENZHEN LEVEKING BIOLOGY ENGINEERING Co.,Ltd. |
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Denomination of invention: Toothpaste composition with strong antibacterial function Granted publication date: 20181106 Pledgee: Agricultural Bank of China Limited by Share Ltd. Chizhou branch Pledgor: ANHUI LEVEKING BIOTECHNOLOGY Co.,Ltd. Registration number: Y2024980008754 |