CN105769745B - Improve the probiotics dentifrice composition of oral health - Google Patents
Improve the probiotics dentifrice composition of oral health Download PDFInfo
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- CN105769745B CN105769745B CN201410803117.3A CN201410803117A CN105769745B CN 105769745 B CN105769745 B CN 105769745B CN 201410803117 A CN201410803117 A CN 201410803117A CN 105769745 B CN105769745 B CN 105769745B
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- probiotics
- oral health
- dentifrice composition
- diester
- manna oligosacchride
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Abstract
The invention discloses a kind of probiotics dentifrice compositions improving oral health, the composition includes the first toothpaste component containing profitable probliotics and manna oligosacchride and the second toothpaste component containing enzyme, mannatide and diester-type surfactant, first and second components keep independent each other, and two kinds of components, which just allocate to combine, when use is applied to tooth.Manna oligosacchride in the probiotics dentifrice composition of the improvement oral health of the present invention and the manna oligosacchride in the catabolite of mannatide can be carbon source needed for growth of probiotics, and oral cavity pathogen cannot utilize manna oligosacchride, and manna oligosacchride can adsorb pathogen, making pathogen, it is hungry and dead, in addition, the basic polypeptide in the catabolite of mannatide can cut off the polysaccharide chains of bacteria cell wall；Diester-type surfactant has potent cleaning and dirt-removing power, can effectively remove and broken thalline, and after subject's use, the quantity of pathogenic bacteria especially Streptococcus mutans substantially reduces, and significantly improves oral health.
Description
Technical field
The invention belongs to daily necessities technical field, especially a kind of probiotics toothpaste group that can improve oral health
Close object.
Background technology
Oral microorganism is made of bacterium, fungi, virus, mycoplasma, protozoon etc., and feature is：Quantity is more, and type is complicated,
Based on bacterium.Microorganism and host, microorganism each other there is extensively and it is complicated it is mutual restrict, relation of interdependence,
Maintain the balance of Oral health behaviours jointly, especially at gingival sulcus position, one side multiple-microorganism is constantly by mucous membrane
Epithelium, adhering to each other in local field planting, growth and breeding between the selective attachment and bacterium of facing, and host then passes through epithelium
Falling off for cell and washing away for level in gingival sulcus fluid, antibody, complement, neutrocyte and lysozyme therebetween, lactoferrin etc. are a variety of
Antimicrobial factors limit the undue growth of local cells；Both there is mutually agglutination between different microorganisms, nutriment is mutually provided
Etc. the mechanism mutually promoted, there is also the mechanism mutually inhibited, the dynamic equilibrium, host between this different microorganisms and micro- life
Dynamic equilibrium between object is an important factor for determining periodontal health.Research in recent years has fully shown in gingival sulcus microorganism
In, there is pathogenic microorganisms that periodontosis can be caused to be such as Streptococcus mutans, porphyromonas gingivalis, symbiosis Actinobacillus etc., there is also
Profitable strain such as Veillonella, neisser's coccus, the Streptococcus sanguis that pathogenic bacteria can be inhibited to grow.In pathogenic microorganisms, make a variation chain
The quantity of coccus is more, fast using the speed of sucrose, and it is fast that lactic acid generates speed；The speed for generating polysaccharide is fast, contact sucrose 15 minutes
Interior 20% or more is converted into intracellular polysaccharide, is main cariogenic bacteria.The Actinobacillus of symbiosis can utilize glucose, lactose, malt
Sugar and sucrose production acid, participate in the development of dental caries.
There are some different microbial habitats, there are the microbiota of oneself feature, oral cavity in everywhere in oral cavity
The balance of microecosystem and the variation of imbalance directly affect the health in oral cavity.The mouth diseases such as halitosis, periodontitis just with these mouths
The activity of chamber microorganism and the ecological balance of oral microecosystem that they are constituted between host are related.Beneficial bacterium subtracts
Less or to disappear be important mechanism that cementopathia occurs, keeps advantage state of the profitable strain at gingival sulcus position that can be effectively prevented
The general generation of periodontosis, the advantage state for rebuilding periodontal profitable strain is that periodontal disease therapeutic is successfully crucial.
The existing bacterium phase that oral microorganism is adjusted using probiotics of the prior art, so that oral cavity probiotics is dominant, pathogenic
Bacterium is reduced, and is achieved the purpose that oral health, but in the oral cavity after introducing probiotics, is not paid attention to giving needed for growth of probiotics breeding
Carbon source, growth and breeding after causing beneficial bacterium to enter patient oral cavity will compete carbon with the dominant pathogenic bacteria in patient oral cavity
Source so that the function and effect of the oral care implement containing profitable probliotics substantially reduce.
Invention content
According to the above-mentioned fact, while probiotics is added in toothpaste addition probiotics can utilize and oral cavity pathogen not
The carbon source that can be utilized, make growth of probiotics breed and oral cavity pathogen it is hungry it is lethal be a kind of new approaches improving oral health.
In order to solve the above technical problems, the technical solution adopted by the present invention is：There is provided it is a kind of improve oral health it is prebiotic
Bacterium dentifrice composition, the composition include the first toothpaste component containing profitable probliotics and manna oligosacchride and poly- containing enzyme, sweet dew
Second toothpaste component of glycopeptide and diester-type surfactant, first and second toothpaste component keep independent, use each other
When two kinds of components just allocate to combine and be applied to tooth；The diester-type surfactant is with formula（1）Shown structure
Compound：
（1）
Formula（1）In, R indicates the alkyl of different carbon atom numbers, the integer that the carbon atom number of R is 8 ~ 18；N is ethylene oxide ether
Unit number, the integer that n is 210 ~ 500.
Preferably, the alkyl is straight chained alkyl or branched alkyl.Straight chained alkyl or branched alkyl make diester-type surface
Two carbochains of activating agent have good hydrophobicity, are conducive to the broken thalline for removing oral cavity.
Preferably, the integer that the n is 240 ~ 400.For toothpaste, surfactant will have certain foaminess
Can, otherwise influence the cleaning action of toothpaste.When the unit number of the ethylene oxide ether of diester-type surfactant is 240 ~ 400, it can make
Diester-type surfactant has good foam performance, can guarantee the cleaning performance of toothpaste.
Most preferably, the integer that the n is 360.For toothpaste, the foam that surfactant generates should not be excessive,
Otherwise it influences to use.When the unit number of the ethylene oxide ether of diester-type surfactant is 360, diester-type surfactant is not only
Have foam performance, and bubble amt optimum.
Preferably, the enzyme is the combination of protease, amylase and lipase.It is preferential to select protease, lipase and shallow lake
Powder enzyme combines, and is so that mannatide is degraded to basic polypeptide and manna oligosacchride because they can cooperate with decomposition mannatide.
When the first toothpaste component containing profitable probliotics and manna oligosacchride and containing enzyme, mannatide and diester-type surfactant
When the allotment combination of two toothpaste components is applied to tooth together, probiotics can carry out growth and breeding using manna oligosacchride, and oral cavity causes
Germ cannot utilize manna oligosacchride, and manna oligosacchride can adsorb pathogen, and making pathogen, it is hungry and dead.In addition, basic polypeptide
Cut off gathering for the connection N-acetyl Portugal amine and N-acetylmuramic acid in the cell wall of oral cavity pathogen, especially Streptococcus mutans
Sugar chain makes bacterium that the cracking of hyposmosis type occur, to kill bacterium.
Preferably, the probiotics is bifidobacterium adolescentis, bifidobacterium lactis, bifidobacterium bifidum, Lactobacillus crispatus, length
Bifidobacterium, bifidobacterium breve, lactobacillus bulgaricus, lactobacillus gasseri, Lactobacillus helveticus, Yue Shi lactobacillus, plant breast bar
At least one of bacterium, lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus salivarius, streptococcus thermophilus.The probiotics has
The characteristics of capable of carrying out growth and breeding using manna oligosacchride, be conducive to probiotics becomes dominant microflora in the oral cavity.
Specifically, the probiotics dentifrice composition for improving oral health is made of the component of following weight percent：
First toothpaste component：
Hydrated silica 24 ~ 28%；Aluminium hydroxide 25 ~ 32%；
Polypropylene glycol 4 ~ 7%；Glycerine 10 ~ 12%；
Sodium carboxymethylcellulose 0.45 ~ 0.5%；Xanthans 0.3 ~ 0.45%；
Carragheen 0.8 ~ 1%；Food flavor 1.3 ~ 1.5%；
Saccharin sodium 0.18 ~ 0.2%；Manna oligosacchride 4 ~ 6%；
Probiotics 6 ~ 10%；Deionized water 12.37 ~ 16.95%；
Second toothpaste component：
Hydrated silica 28 ~ 32%；Aluminium hydroxide 28 ~ 32%；
Polypropylene glycol 4 ~ 7%；Glycerine 10 ~ 12%；
Sodium carboxymethylcellulose 0.45 ~ 0.5%；Xanthans 0.3 ~ 0.45%；
Carragheen 0.8 ~ 1%；Diester-type surfactant 1 ~ 2%；
Food flavor 1.3 ~ 1.5%；Saccharin sodium 0.18 ~ 0.2%；
Proteinase-10 .08 ~ 0.15%；Lipase 0.08 ~ 0.15%%；
Amylase 0.08 ~ 0.15%；Mannatide 4 ~ 6%；
Deionized water 12.57 ~ 14.06%.
After subject is using the probiotics dentifrice composition of above-mentioned improvement oral health, the average colony shape of Streptococcus mutans
Reduced rate at unit is 81.6 ~ 84.6%.
Preferably, the probiotics dentifrice composition for improving oral health is made of the component of following weight percent：
First toothpaste component：
Hydrated silica 28%；Aluminium hydroxide 28%；
Polypropylene glycol 5%；Glycerine 10%；
Sodium carboxymethylcellulose 0.5%；Xanthans 0.4%；
Carragheen 0.8%；Food flavor 1.5%；
Saccharin sodium 0.2%；Manna oligosacchride 5%；
Probiotics 8%；Deionized water 12.6%；
Second toothpaste component：
Hydrated silica 32%；Aluminium hydroxide 30%；
Polypropylene glycol 5%；Glycerine 10%；
Sodium carboxymethylcellulose 0.5%；Xanthans 0.4%；
Carragheen 0.8%；Diester-type surfactant 1.5%；
Food flavor 1.5%；Saccharin sodium 0.2%；
Proteinase-10 .1%；Lipase 0.1%；
Amylase 0.1%；Mannatide 5%；
Deionized water 12.8%.
After subject is using the probiotics dentifrice composition of above-mentioned improvement oral health, the average colony shape of Streptococcus mutans
Reduced rate at unit is 87.8%.
The first toothpaste component in the probiotics dentifrice composition of the improvement oral health of the present invention is containing profitable probliotics and sweet
Reveal oligosaccharides, manna oligosacchride is the carbon source of probiotics, and probiotics is made to keep activity；Second toothpaste component contains enzyme, mannatide
With diester-type surfactant, when the first toothpaste component and the second toothpaste component are applied to tooth together, protease, lipase
Mannatide is decomposed with amylase, mannatide is made to be degraded to basic polypeptide and manna oligosacchride.Probiotics can utilize
Manna oligosacchride carries out growth and breeding, and oral cavity pathogen cannot utilize manna oligosacchride, and manna oligosacchride can adsorb pathogen, make disease
It is hungry and dead for opportunistic pathogen；In addition, the connection in the cell wall of basic polypeptide cut-out oral cavity pathogen, especially Streptococcus mutans
The polysaccharide chains of N-acetyl Portugal amine and N-acetylmuramic acid make bacterium that the cracking of hyposmosis type occur, to kill bacterium；Dibasic acid esters
Two hydrophobic carbochains of type surfactant adsorb the phospholipid bilayer of broken bacterium, hydrophobic carbon by intermolecular active force
The phenyl ring of chain link enhances the adsorption capacity of hydrophobic carbochain and the phospholipid bilayer of broken bacterium, while diester-type surface-active
Agent has suitable foam performance again, reinforces the removing of broken thalline.
It is understood that the new approaches according to the present invention for improving oral health, other than toothpaste, mouthwash can wrap
Include the first mouthrinse components containing profitable probliotics and manna oligosacchride and containing enzyme, mannatide and diester-type surfactant
Second mouthrinse components；Oral spray may include the first spray component containing profitable probliotics and manna oligosacchride and contain
Second spray component of enzyme, mannatide and diester-type surfactant；Cleaning agent for mouth cavity may include containing profitable probliotics
With the first detergent components of manna oligosacchride and contain the second detergent group of enzyme, mannatide and diester-type surfactant
Point；Chewing gum may include the first gum components containing profitable probliotics and manna oligosacchride and containing enzyme and mannatide
Two gum components.
The beneficial effects of the invention are as follows：It is substantially reduced for the function and effect of the existing oral care implement containing profitable probliotics
The case where, the catabolite of the manna oligosacchride and mannatide of the probiotics dentifrice composition of improvement oral health of the invention
In manna oligosacchride can be carbon source needed for the growth of probiotics, and oral cavity pathogen cannot utilize manna oligosacchride, and sweet dew is few
Sugar can adsorb pathogen, and making pathogen, it is hungry and dead, in addition, the basic polypeptide in the catabolite of mannatide can be cut off
The polysaccharide chains of bacteria cell wall；Diester-type surfactant has potent cleaning and dirt-removing power, can effectively remove and broken
Thalline, after subject's use, the amount of pathogenic bacteria especially Streptococcus mutans substantially reduces, and significantly improves oral health.
Specific implementation mode
The following describes the present invention in detail with reference to examples.
Embodiment 1
In the reaction kettle of the esterification for carrying condenser, water knockout drum at 10 liters, 5 kilograms of toluene, 4.48 kilograms of straight chains are sequentially added
Octyl phenol polyoxyethylene ether（Alkyl phenol polyoxyethylene ether, R=8, n=210）, 0.52 kilogram of phthalic anhydride, with 150 revs/min
The mixing speed of clock stirs 30 minutes, makes straight chain octyl phenol polyoxyethylene ether（Alkyl phenol polyoxyethylene ether, R=8, n=210）And neighbour
Phthalate anhydride is completely dissolved in toluene；0.05 kilogram of p-methyl benzenesulfonic acid is added, and with 150 revs/min of stirring speed
Degree stirring 10 minutes, Catalyzed by P-Toluenesulfonic Acid straight chain octyl phenol polyoxy ether（Alkyl phenol polyoxyethylene ether, R=8, n=210）With
Esterification occurs for phthalic anhydride；110 DEG C are warming up to, and small with the stirring of 150 revs/min of mixing speed, back flow reaction 4
When；The water in water knockout drum is finally removed, toluene is extracted using vacuum pump, is cooled to room temperature, obtain diester-type surfactant, it should
Diester-type surfactant structure is as follows：
（R=8）.
Embodiment 2
At 10 liters with condenser, water knockout drum reaction kettle of the esterification in, sequentially add 5 kilograms of toluene, 4.92 kilograms it is different pungent
Base phenol polyethenoxy ether（Alkyl phenol polyoxyethylene ether, R=12, n=500）, 0.08 kilogram of phthalic anhydride, with 150 revs/min
Mixing speed stir 30 minutes, make isooctyl phenol polyethoxylate（Alkyl phenol polyoxyethylene ether, R=12, n=500）With adjacent benzene
Dicarboxylic acid anhydride is completely dissolved in toluene；0.003 kg of phosphoric acid is added, and 10 points are stirred with 150 revs/min of mixing speed
Clock, phosphoric acid catalyzed isooctylphenol polyoxy ether（Alkyl phenol polyoxyethylene ether, R=12, n=500）Ester occurs with phthalic anhydride
Change reaction；It is warming up to 110 DEG C, and with the stirring of 150 revs/min of mixing speed, back flow reaction 4 hours；Finally remove water knockout drum
In water, extract toluene using vacuum pump, be cooled to room temperature, obtain diester-type surfactant, the diester-type surfactant
Structure is as follows：
（R=12）.
Embodiment 3
In the reaction kettle of the esterification for carrying condenser, water knockout drum at 10 liters, 5 kilograms of toluene, 4.85 kilograms of straight chains are sequentially added
Dodecyl phenol polyethenoxy ether（Alkyl phenol polyoxyethylene ether, R=18, n=360）, 0.15 kilogram of phthalic anhydride, with 150
Rev/min mixing speed stir 30 minutes, make straight chain dodecyl phenol polyethenoxy ether（Alkyl phenol polyoxyethylene ether, R=18,
n=360）It is completely dissolved in toluene with phthalic anhydride；It adds 0.02 kilogram of benzene sulfonic acid, and is stirred with 150 revs/min
It mixes speed to stir 10 minutes, benzene sulfonic acid is catalyzed straight chain dodecylphenol polyoxy ether（Alkyl phenol polyoxyethylene ether, R=18, n=
360）Esterification occurs with phthalic anhydride；110 DEG C are warming up to, and with the stirring of 150 revs/min of mixing speed, reflux
Reaction 4 hours；The water in water knockout drum is finally removed, toluene is extracted using vacuum pump, is cooled to room temperature, obtains the work of diester-type surface
Property agent, the diester-type surfactant structure are as follows：
（R=18）.
Embodiment 4
The probiotics dentifrice composition for improving oral health consists of the following compositions（Weight percent）：
Prepare the first toothpaste component and the second toothpaste component with conventional method, be respectively charged into after preparing it is intermediate with every
In the soft box of toothpaste, the first toothpaste component and the second toothpaste component are blended on such as toothbrush by when use, mixed mixing
Object.
Embodiment 5
The probiotics dentifrice composition for improving oral health consists of the following compositions（Weight percent）：
Embodiment 6
The probiotics dentifrice composition for improving oral health consists of the following compositions（Weight percent）：
Embodiment 7
It is used in subject oral cavity before and after the probiotics dentifrice composition of present invention improvement oral health by subject
The quantity of Streptococcus mutans changes to investigate the function that the present invention improves the probiotics dentifrice composition of oral health.
One, material is tried out：The probiotics dentifrice composition of the improvement oral health of embodiment 4 ~ 6.
Two, object is tried out：30 subjects.
Three, test method：
Experimental group：30 subjects are randomly divided into 3 groups, respectively 6 groups of 4 groups of embodiment, 5 groups of embodiment and embodiment,
Every group 10；Subject aspirates to collect bacterium in tongue back side before experiment, then dilutes the sample gradient of collection
It is cultivated under 37 DEG C of anaerobic condition with blood agar culture-medium afterwards, after 72 hours, selects rounded, surface is smooth, diameter
0.5-1mm around has α（Green）Or γ（It is colourless）Zone of hemolysis or β（It is transparent）The bacterium colony of zone of hemolysis is counted.Then subject
The dentifrice composition for using the present embodiment 4 ~ 6 respectively brushes teeth each 1 time sooner or later, uses 2 grams of toothpaste every time, continue 3 months daily,
It is brushed teeth using horizontal trembling method；After 3 months, subject aspirates in the tongue back other side to collect bacterium, then by collection
It is cultivated under 37 DEG C of anaerobic condition with blood agar culture-medium after sample gradient dilution, after 72 hours, selects rounded, table
Face is smooth, and diameter 0.5-1mm around has α（Green）Or γ（It is colourless）Zone of hemolysis or β（It is transparent）The bacterium colony of zone of hemolysis is counted
Number.
Four, test result：
| Group | Baseline is averaged CFU | Use average CFU after 3 months | The reduced rate % of average CFU based on baseline |
| 4 groups of embodiment | 4.1×104 | 0.5×104 | 87.8 |
| 5 groups of embodiment | 3.9×104 | 0.6×104 | 84.6 |
| 6 groups of embodiment | 3.8×104 | 0.7×104 | 81.6 |
CFU=Colony Forming Unit
Average CFU reduced rates=[（The baseline CFU- that is averaged uses CFU average values after 3 months）/ baseline is averaged CFU] × 100%.
As seen from the above table, after using the probiotics dentifrice composition of the improvement oral health of the present invention, Streptococcus mutans
The reduced rate that average colony forms unit is 81.6 ~ 87.8%, and Streptococcus mutans quantity substantially reduces.
Those skilled in the art do not depart from the present invention essence and spirit, can there are many deformation scheme realize the present invention,
The foregoing is merely preferably feasible embodiments of the invention, not thereby limit to the interest field of the present invention, all with this
Equivalent structure made by description of the invention changes, and is both contained within the interest field of the present invention.
Claims (8)
1. a kind of probiotics dentifrice composition improving oral health, which is characterized in that the composition includes containing profitable probliotics
The second toothpaste component with the first toothpaste component of manna oligosacchride and containing enzyme, mannatide and diester-type surfactant,
First and second toothpaste component keeps independent each other, and two kinds of components, which just allocate to combine, when use is applied to tooth；
The diester-type surfactant is with formula（1）The compound of shown structure：
（1）
Formula（1）In, R indicates the alkyl of different carbon atom numbers, the integer that the carbon atom number of R is 8 ~ 18；N is the unit of ethylene oxide ether
Number, the integer that n is 210 ~ 500.
2. improving the probiotics dentifrice composition of oral health as described in claim 1, which is characterized in that the alkyl is straight
Alkyl group or branched alkyl.
3. as described in claim 1 improve oral health probiotics dentifrice composition, which is characterized in that the n be 240 ~
400 integer.
4. improving the probiotics dentifrice composition of oral health as claimed in claim 3, which is characterized in that the n is 360
Integer.
5. improving the probiotics dentifrice composition of oral health as described in claim 1, which is characterized in that the enzyme is albumen
The combination of enzyme, amylase and lipase.
6. improving the probiotics dentifrice composition of oral health as described in claim 1, which is characterized in that the probiotics is
Bifidobacterium adolescentis, bifidobacterium lactis, bifidobacterium bifidum, Lactobacillus crispatus, bifidobacterium longum, bifidobacterium breve, Bao Jiali
Sub- lactobacillus, lactobacillus gasseri, Lactobacillus helveticus, Yue Shi lactobacillus, lactobacillus plantarum, lactobacillus reuteri, rhamnose breast bar
At least one of bacterium, Lactobacillus salivarius, streptococcus thermophilus.
7. as claim 1 ~ 6 any one of them improves the probiotics dentifrice composition of oral health, which is characterized in that described
Dentifrice composition is made of the component of following weight percent：
First toothpaste component：
Hydrated silica 24 ~ 28%；Aluminium hydroxide 25 ~ 32%；
Polypropylene glycol 4 ~ 7%；Glycerine 10 ~ 12%；
Sodium carboxymethylcellulose 0.45 ~ 0.5%；Xanthans 0.3 ~ 0.45%；
Carragheen 0.8 ~ 1%；Food flavor 1.3 ~ 1.5%；
Saccharin sodium 0.18 ~ 0.2%；Manna oligosacchride 4 ~ 6%；
Probiotics 6 ~ 10%；Deionized water 12.37 ~ 16.95%；
Second toothpaste component：
Hydrated silica 28 ~ 32%；Aluminium hydroxide 28 ~ 32%；
Polypropylene glycol 4 ~ 7%；Glycerine 10 ~ 12%；
Sodium carboxymethylcellulose 0.45 ~ 0.5%；Xanthans 0.3 ~ 0.45%；
Carragheen 0.8 ~ 1%；Diester-type surfactant 1 ~ 2%；
Food flavor 1.3 ~ 1.5%；Saccharin sodium 0.18 ~ 0.2%；
Proteinase-10 .08 ~ 0.15%；Lipase 0.08 ~ 0.15%；
Amylase 0.08 ~ 0.15%；Mannatide 4 ~ 6%；
Deionized water 12.57 ~ 14.06%.
8. improving the probiotics dentifrice composition of oral health as claimed in claim 7, which is characterized in that the dentifrice composition
Object is made of the component of following weight percent：
First toothpaste component：
Hydrated silica 28%；Aluminium hydroxide 28%；
Polypropylene glycol 5%；Glycerine 10%；
Sodium carboxymethylcellulose 0.5%；Xanthans 0.4%；
Carragheen 0.8%；Food flavor 1.5%；
Saccharin sodium 0.2%；Manna oligosacchride 5%；
Probiotics 8%；Deionized water 12.6%；
Second toothpaste component：
Hydrated silica 32%；Aluminium hydroxide 30%；
Polypropylene glycol 5%；Glycerine 10%；
Sodium carboxymethylcellulose 0.5%；Xanthans 0.4%；
Carragheen 0.8%；Diester-type surfactant 1.5%；
Food flavor 1.5%；Saccharin sodium 0.2%；
Proteinase-10 .1%；Lipase 0.1%；
Amylase 0.1%；Mannatide 5%；
Deionized water 12.8%.
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| CN106821950A (en) * | 2017-01-23 | 2017-06-13 | 衡阳美娇七商贸有限公司 | The oral care composition and its application of a kind of antibacterial and whitening |
| CN106581159B (en) * | 2017-01-24 | 2020-05-12 | 广州薇美姿实业有限公司 | Oral care composition for children and morning and evening benefiting combined toothpaste for children |
| CN107158040B (en) * | 2017-04-12 | 2020-12-08 | 华南农业大学 | Oral micro-ecological preparation and preparation method thereof |
| CN107897881A (en) * | 2017-10-19 | 2018-04-13 | 徐州统食品工业有限公司 | A kind of probiotic composition for being used to improve oral health |
| CN109394554A (en) * | 2018-12-29 | 2019-03-01 | 陈欣欣 | A kind of probiotics toothpaste and preparation method thereof |
| CN111558033A (en) * | 2020-05-14 | 2020-08-21 | 广州中昱医学生物科技有限公司 | Oral cavity cleaning composition and application thereof |
| CN113398059A (en) * | 2021-07-13 | 2021-09-17 | 镇江市天益生物科技有限公司 | Toothpaste containing oral probiotics and preparation method thereof |
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Effective date of registration: 20230525 Address after: 518000 room 1201, building a, Qiaode science and Technology Park, No.7, West District, Guangming Gaoxin Park, Tianliao community, Yutang street, Guangming District, Shenzhen City, Guangdong Province Patentee after: Benhu (Shenzhen) Investment Co.,Ltd. Address before: 518000 room 1201, building a, Qiaode science and Technology Park, No.7, West District, Guangming Gaoxin Park, Tianliao community, Yutang street, Guangming District, Shenzhen City, Guangdong Province Patentee before: SHENZHEN BAGEMEI BIOLOGICAL TECHNOLOGY Co.,Ltd. |
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| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 518000 room 1201, building a, Qiaode science and Technology Park, No.7, West District, Guangming Gaoxin Park, Tianliao community, Yutang street, Guangming District, Shenzhen City, Guangdong Province Patentee after: Shenzhen Dinghong Biotechnology Co.,Ltd. Address before: 518000 room 1201, building a, Qiaode science and Technology Park, No.7, West District, Guangming Gaoxin Park, Tianliao community, Yutang street, Guangming District, Shenzhen City, Guangdong Province Patentee before: Benhu (Shenzhen) Investment Co.,Ltd. |