TWI381858B - Vaginal cleaner and manufacture method thereof - Google Patents

Description

Female privacy cleaner and its manufacturing method

The present invention relates to a cleaning agent, particularly a female intimate cleansing agent and a method of manufacturing the same.

In recent years, microbiological studies have shown that there are tens of trillions and as many as 120 or more microorganisms in some organs of the human body, such as the intestines or the vagina. Among them, anaerobic bacteria such as bifidobacteria and lactic acid bacteria are beneficial to the human body, accounting for about 95%, while anaerobic bacteria such as Escherichia coli which are harmful to human body only account for about 1%. These anaerobic bacteria are mutually constrained and interdependent in the organs, thereby maintaining the balance of the microbial dynamic ecosystem in the organs and keeping the human body in a healthy state. Therefore, when the microbial kinetic ecosystem in these organs is damaged, the organ will be infected by the pathogen to cause disease.

Take female vaginitis as an example. There are a certain number of lactic acid bacteria in the vagina of healthy women. These lactic acid bacteria use the glycogen secreted by the vaginal mucosa as an energy source to reproduce and colonize the vagina. Moreover, these lactic acid bacteria will compete with other pathogenic bacteria in the vagina to become a dominant flora, thereby preventing other pathogenic bacteria from proliferating in the vagina and maintaining the cleanliness in the vagina. However, when healthy women are in poor sanitation or decline in resistance, it is easy for the vagina to be infected by microorganisms such as bacteria, mold or trichomoniasis, causing lactic acid bacteria to be attacked and eliminated by these pathogens, thereby destroying the microbial dynamic ecosystem in the vagina. Balance and lead to the occurrence of female vaginitis.

Generally, in the treatment of female vaginitis, most of them are treated with sulfonamides, antibiotics or other disinfecting drugs. However, although this treatment method can achieve the effect of eradicating pathogenic bacteria, since this treatment method does not have the species identification, it can inhibit the proliferation of lactic acid bacteria in the vagina and cause the vagina together while quenching the pathogenic bacteria. The microbial dynamic ecosystem within the system cannot be balanced, resulting in the loss of the lactic acid bacteria's restriction on other pathogens. At the same time, if long-term treatment with sulfonamides, antibiotics or other disinfecting drugs is used, it is easy to make the pathogens resistant and the therapeutic effect is reduced. Moreover, this treatment is not applicable to pregnant women to avoid interference with the normal growth and development of the fetus. Therefore, the traditional treatment of female vaginitis is easy to use due to the above factors.

At present, in the treatment of female vaginitis, a microbial treatment method has been developed, which directly treats the lactic acid bacteria in the vagina, so that the lactic acid bacteria form a dominant group in the vagina, so as to restrict other pathogenic bacteria in the vagina. The effect of internal proliferation. However, the conventional method of treatment of microbial only E. coli (Escherichia coli), Pseudomonas aeruginosa (Pseudomonas aeruginosa), Staphylococcus aureus (Staphylococcus aureus) and Streptococcus (Streptococcus) Inhibition of bacteria and the like. However, Candida albicans and Gardnerella vaginalis did not produce antagonism. Moreover, in this microbial treatment method, the lactic acid bacteria need to be subjected to fermentation culture for 36 to 72 hours to obtain the required amount of lactic acid bacteria, so that it can be used after subsequent processing. Therefore, it will bear considerable time and cost pressure in manufacturing.

In view of the above problems, the present invention provides a female intimate cleansing agent for improving the conventional use of sulfonamides, antibiotics or other disinfecting drugs for treating female vaginitis, which is susceptible to pathogenic bacteria and unsuitable for pregnant women. In order to improve the current microbial treatment, it is unable to antagonize Candida albicans and increase the cost caused by too long process time.

The invention discloses a method for manufacturing a female privacy cleaner, which comprises the following steps: First, inoculating at least one lactic acid bacteria strain into a culture solution to form a lactic acid bacteria culture solution. Next, the lactic acid bacteria culture solution is cultured in an environment of 30 ° C to 40 ° C, and a fermentation promoter is added to the lactic acid bacteria culture solution to cause a biochemical reaction between the fermentation promoter and the lactic acid bacteria strain. Then, the lactic acid bacteria culture solution is taken out from the environment of 30 ° C to 40 ° C, and a lactic acid bacteria culture liquid is subjected to a centrifugation operation to obtain a lactic acid bacteria fermentation liquid and a microbial cell. Next, a lactic acid bacterium fermentation broth having a hydrogen peroxide and a bacteriocin is prepared to complete the preparation of a female privacy cleaner.

The present invention also discloses a female intimate cleansing agent which is prepared by the above-mentioned method for manufacturing a female intimate cleansing agent. The female privacy cleaner includes a lactic acid bacteria fermentation liquid having a hydrogen peroxide and a bacteriostatin.

In the method for manufacturing a female privacy cleaner according to the present invention, a fermentation accelerator is added to a lactic acid bacteria culture solution during the cultivation of the lactic acid bacteria culture solution, and a biochemical reaction is carried out by the fermentation accelerator and the lactic acid bacteria strain, and a lactic acid bacteria strain is provided. The growth energy required for reproductive growth. Therefore, the content/concentration of the lactic acid bacteria strain in the lactic acid bacteria culture solution can be increased, and the culture time of the lactic acid bacteria culture liquid can be greatly shortened, thereby saving the preparation time and cost of the female private cleaning agent.

The above description of the present invention and the following description of the embodiments of the present invention are intended to illustrate and explain the principles of the invention.

Please refer to "FIG. 1". The female intimate cleansing agent disclosed in an embodiment of the present invention is applied to the prevention and treatment of female vaginitis. In the manufacture of a female intimate cleansing agent, at least one strain of lactic acid bacteria is first inoculated into a culture solution to form a lactic acid bacteria culture solution (S101). Among them, the selected lactic acid bacteria strain is selected from Lactobacillus casei , Lactobacillus paracasei , Lactobacillus casei sp. Rhamnosus , and Lactobacillus acidophilus. acidophilus), Bifidobacterium coli (Lactobacillus bifidus), Lactobacillus brevis (Lactobacillus brevis), Lactobacillus bulgaricus (Lactobacillus bulgaricus), Lactobacillus cellobiose (Lactobacillus cellobiosus), sol Lactobacillus (Lactobacillus collinoides), Daibai Shi Lactobacillus delbrueckii , Lactobacillus fermentum , Lactobacillus jensenii , Lactobacillus gasseri , Lactobacillus plantarum , Lactobacillus rhamnosus , cellobiose Lactobacillus (Lactobacillus cellobiosus), crimp Lactobacillus (Lactobacillus crispatus), lord Lactobacillus (Lactobacillus reuteri) or De law g Lactobacillus (Lactobacillus delbrueckil) strain and the like, Mixtures of the above strains. The culture medium which can be used is one of MRS medium, whey, milk and starch, or a mixture thereof. Among them, milk can include: concentrated milk, skimmed milk and low-fat milk.

In the present embodiment, Lactobacillus casei, Lactobacillus bergii or Lactobacillus brevis is inoculated in a liquid MRS medium to form a lactic acid bacteria culture solution as an example, but not limited thereto.

Next, the lactic acid bacteria culture solution is placed in an environment of 30 ° C to 40 ° C for 12 to 20 hours, for example, for 16 to 18 hours. The length of this culture time depends on the proliferation rate of the lactic acid bacteria strain in the culture solution. Further, a fermentation accelerator is added to the lactic acid bacteria culture solution before the lactic acid bacteria culture solution is placed in the above culture environment or when the lactic acid bacteria culture solution is cultured in the above culture environment. For example, fermentation promoters such as chitin and oligosaccharides (such as xylooligosaccharide) are used, but not limited thereto. At the same time, in the culturing process of the lactic acid bacteria culture solution, the lactic acid bacteria culture solution can be further stirred, whereby the fermentation promoter can be uniformly mixed in the lactic acid bacteria culture solution (S102).

Therefore, when the lactic acid bacteria strain in the lactic acid bacteria culture solution and the fermentation accelerator biochemically react, the lactic acid bacteria strain can fully utilize the growth energy provided by the fermentation accelerator to accelerate the proliferation speed (or concentration) in the lactic acid bacteria culture solution, Further, the culture time of the lactic acid bacteria culture solution is effectively shortened.

Further, as shown in the "Fig. 2", in another embodiment of the present invention, when the lactic acid bacteria culture solution containing the hairpin promoter is cultured in an environment of 30 ° C to 40 ° C, carbon dioxide can be introduced together ( CO ₂ ) is in the lactic acid bacteria culture solution (S202) to accelerate the proliferation rate of the lactic acid bacteria strain by the anaerobic property of the lactic acid bacteria strain. Therefore, the culture time of the lactic acid bacteria culture solution can be effectively shortened by the step of introducing carbon dioxide into the lactic acid bacteria culture solution.

Please refer to "Fig. 1" again. After the concentration of the lactic acid bacteria strain in the lactic acid bacteria culture solution reaches the preset concentration, the lactic acid bacteria culture solution is taken out from the environment of 30 ° C to 40 ° C. Thereafter, the lactic acid bacteria culture solution is subjected to centrifugation at a low temperature of 3 ° C to 10 ° C. The lactic acid bacteria culture solution was centrifuged for 15 minutes at a speed of 4000 rpm (4000 rpm/min) by a centrifuge at 4 ° C, for example. The cells in the lactic acid bacteria culture solution are separated from the lactic acid bacteria fermentation liquid (that is, the supernatant). Therefore, after the completion of the centrifugation operation, the lactic acid bacteria fermentation liquid and the bacterial cells (S103) can be obtained.

Next, a lactic acid bacteria fermentation liquid (S104) containing a component such as hydrogen peroxide (H ₂ O ₂ ) and bacteriocin is collected. Moreover, the cells can be stored or discarded for visual use. Then, the lactic acid bacteria fermentation liquid (S105) is filtered by filtering the lactic acid bacteria fermentation liquid by a molecular sieve to filter out other impurities in the lactic acid bacteria fermentation liquid. The lactic acid bacteria fermentation broth has almost only components such as hydrogen peroxide and bacteriocin.

After filtering the lactic acid bacteria fermentation liquid, the surfactant can be selectively added to the lactic acid bacteria fermentation liquid to complete the preparation of the female private cleaning agent. This female intimate cleanser has a pH value between 3.5 and 4.5, for example having a pH of 4.0. Among them, the surfactants that can be used are zwitterionic surfactants, nonionic surfactants or anionic surfactants, such as sodium laureth sulfate (SLS) and ammonium lauryl sulfate (Ammonium lauryl sulfate). , referred to as ALS) and so on. In addition, while adding a surfactant, an acidic component such as acetic acid, citric acid or lactic acid may be selectively added to the lactic acid bacteria fermentation broth (S106), so that the female privacy cleaner can be normally maintained between 3.5 and 4.5. The pH value between the two increases the bacteriostatic effect of the lactic acid bacteria fermentation broth.

Thereafter, the antibacterial ability of the female intimate cleansing agent of the present embodiment was tested, and the tested strains were Candida albicans, Streptococcus agalactiae , E. coli , vaginal plus Natto, Klebsiella pneumoniae and Proteus mirabilis . First, the female intimate cleansing agent is dispensed into a plurality of test tubes so that each test tube has 500 μl (microliter) of female intimate cleansing agent. Then, 25 μl of the above-mentioned bacterial strains were separately added to the test tube, and the bacterial liquid was mixed with the female private cleansing agent, respectively, 2.5 ml of the bacterial culture solution was added, and finally, the sterile physiological saline solution was added to make the liquid volume of each test tube. It is 5ml. Among them, the above-mentioned strains are prepared by picking up a cultured colony of 18-24 hours from a blood agar plate to a BD Phoenix ID Broth, and adjusting to a standard turbidity equivalent to MacFarland 0.5. The suspension has a bacterial liquid concentration equivalent to 1.5 × 10 ⁸ CFU/ml, that is, 1.5 × 10 ⁸ colony forming units (CFU) per ml.

Next, the test tube mixed with the bacterial liquid was placed in a carbon dioxide incubator, and after culturing for 18-24 hours in an environment of 35 ° C, the test tube was taken out from the carbon dioxide incubator, and the growth state of the above-mentioned strain was observed, and the results were as follows. Table 1 shows.

Therefore, the female intimate cleansing agent disclosed in this embodiment has good antibacterial activity against pathogenic bacteria such as Candida albicans, Streptococcus mutans, Escherichia coli, Gardnerella vaginalis, Klebsiella pneumoniae and S. variabilis/ Sterilization ability.

In addition, as shown in the "Fig. 2", in another embodiment of the present invention, in order to further increase the sterilizing ability of the female private cleaning agent, it is also possible to additionally add the surfactant when the lactic acid bacteria fermentation liquid is added. The hydrogen peroxide is in the lactic acid bacteria fermentation liquid (S206), so that the female intimate cleaning agent after the preparation has more hydrogen peroxide content to achieve better sterilization efficiency. In addition, oligosaccharides (such as xylooligosaccharide) may also be added to the lactic acid bacteria fermentation broth to increase the activity of the native lactic acid bacteria in the vagina.

In application, the female intimate cleansing agent disclosed in one embodiment of the present invention can be combined with an excipient so that the female intimate cleansing agent can have different use forms. For example, a female intimate cleansing agent can be combined with a water-soluble polymer, a polymer polysaccharide polymer, water, saline, petroleum jelly, glycerin, glycerin, etc. to form a liquid, a spray, a gel. Female intimate cleansers in the form of capsules or lotions. In addition, a mixture of three kinds of colloids such as Xanthan Gum, carboxymethyl cellulose (CMC) and hydroxymethyl guar (HM21) may be added, or one of them may be used to effectively prolong the lactic acid bacteria fermentation liquid retention. Time in the skin or vaginal mucosa to enhance the antibacterial effect. In addition, a mixture of natural plant essential oils such as Sage Extract, Chamomile Extract, Calendula Extract or thymol may be added or added to increase The bacteriostatic effect of the lactic acid bacteria fermentation broth. The excipient in combination with the female intimate detergent may be further disposed on a carrier, for example, a liquid, spray, gel, dry powder, or emulsion form female intimate cleaning agent is disposed on the sanitary napkin and the sanitary pad. On the carrier such as wet tissue or condom, the female privacy cleaner can be widely applied to various needs.

For example, in the form of a gel-type female intimate cleansing agent, a female intimate cleansing agent is coated in a gel composed of a water-soluble polymer to be used as an external paint or a plug. In the present embodiment, the female intimate cleansing agent in the gel form is used as a plugging agent as an example, but is not limited thereto. Wherein, the water-soluble polymer is composed of a liquid polyethylene glycol or polyvinyl alcohol and a solid polyethylene glycol, polyvinyl alcohol, carboxylic acid cellulose or starch, for example, liquid polyethylene A polymer composed of a diol and a solid carboxylic acid-based cellulose.

Then, the female intimate cleansing agent in a gel form is placed in the vagina infected with pathogenic bacteria such as Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus, Corynebacterium vaginalis, and Candida albicans. Since the vagina is infected with pathogenic bacteria, its pH value will be greater than 4.5, which is not suitable for the growth of lactic acid bacteria. Therefore, the lactic acid bacteria become a vulnerable group in the vagina, which causes vaginitis. Accordingly, when the gel-form female intimate cleansing agent is used for the treatment of vaginitis, firstly, the high molecular polymer can effectively prolong the time in which the female intimate cleansing agent stays in the vaginal mucosa and enhance the antibacterial effect. At this time, in addition to inhibiting the proliferation of pathogenic bacteria by the antibacterial agent of the female intimate cleansing agent, the pathogen can be quenched by hydrogen peroxide, thereby reducing Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus in the vagina, The number of pathogenic bacteria such as Streptococcus, Corynebacterium vaginalis and Candida albicans.

Secondly, the inhibitory effect of the antibacterial agent on the pathogen is further enhanced by the surfactant in the female privacy agent. Finally, since the pH of the female intimate cleansing agent is between 3.5 and 4.5, a preferred growth environment for the lactic acid bacteria present in the vagina can be provided. With the interaction of bacteriocin and hydrogen peroxide, the lactic acid bacteria in the vagina can be restored to the state of the dominant group within a short period of time, thereby restoring the environment in the vagina to a healthy state, thereby solving the vaginitis. problem.

The female privacy cleaner and the method for manufacturing the same disclosed by the present invention can effectively increase the strain of lactic acid bacteria by stirring and adding a fermentation accelerator during the cultivation process of the lactic acid bacteria culture solution, and selectively introducing carbon dioxide to create an anaerobic environment. The concentration in the lactic acid bacteria culture solution is shortened, and the culture time of the lactic acid bacteria culture solution is shortened. Therefore, the manufacturing and production time of the detergent in the privacy of women can be greatly reduced. Moreover, the surfactant is added to the lactic acid bacteria fermentation liquid and hydrogen peroxide is introduced, so that the female privacy agent can have good antibacterial and bactericidal ability at the same time.

Although the embodiments of the present invention are disclosed above, it is not intended to limit the present invention, and those skilled in the art, regardless of the spirit and scope of the present invention, the shapes, structures, and features described in the scope of the present application. And the spirit of the invention is subject to change. Therefore, the scope of patent protection of the present invention is subject to the scope of the patent application attached to the specification.

1 is a schematic view showing a manufacturing process of an embodiment of the present invention;

Figure 2 is a schematic view showing the manufacturing process of another embodiment of the present invention.

Claims (38)

A method for manufacturing a female intimate cleansing agent, comprising the steps of: inoculating at least one strain of lactic acid bacteria into a culture solution to form a lactic acid bacteria culture solution; and culturing the lactic acid bacteria culture solution in an environment of 30 ° C to 40 ° C, and Adding a fermentation promoter to the lactic acid bacteria culture solution, the fermentation accelerator and the lactic acid bacteria strain are subjected to a biochemical reaction; the lactic acid bacteria culture liquid is taken out from the environment of 30 ° C to 40 ° C, and the lactic acid bacteria culture liquid is subjected to a reaction. Centrifuging operation to obtain a lactic acid bacteria fermentation liquid and a bacterial cell; and collecting the lactic acid bacteria fermentation liquid, wherein the lactic acid bacteria fermentation liquid has a hydrogen peroxide and a bacteriocin; wherein the fermentation accelerator is chitin. The lactic acid bacteria culture solution is subjected to the centrifugation operation at an environment of from 3 ° C to 10 ° C. The method for manufacturing a female privacy cleaner according to claim 1, wherein after the step of collecting the lactic acid fermentation broth, further comprising the step of adding a surfactant to the lactic acid fermentation broth, the surfactant and the inhibition The bacteriocin takes a chemical reaction. The method for producing a female intimate cleansing agent according to claim 1, wherein the lactic acid bacteria strain is composed of Lactobacillus casei, Lactobacillus gasseri, and Lactobacillus. The method for producing a female intimate cleansing agent according to claim 1, wherein the lactic acid bacteria strain is one selected from the group consisting of Lactobacillus casei, Lactobacillus bulgaricus, L. laurel, and a mixture thereof. The method for producing a female privacy cleaner according to claim 1, wherein the culture solution is selected from the group consisting of a milk, MRS medium, whey, starch, and a mixture thereof. The method of manufacturing a female privacy cleaner according to claim 5, wherein the milk is selected from the group consisting of concentrated milk, skimmed milk or low fat milk. The method for producing a female intimate cleansing agent according to claim 1, wherein the lactic acid bacteria culture solution is cultured in the environment of 30 ° C to 40 ° C for 12 to 20 hours. The method for producing a female intimate cleansing agent according to claim 7, wherein the lactic acid bacteria culture solution is cultured in the environment of 30 ° C to 40 ° C for 16 to 18 hours. The method for producing a female intimate cleansing agent according to claim 1, wherein the lactic acid bacteria culture solution is cultured in the environment of 30 ° C to 40 ° C, and further comprises an operation of stirring the lactic acid bacteria culture solution. The method for producing a female intimate cleansing agent according to claim 1, wherein the lactic acid bacteria culture solution is cultured in the environment of 30 ° C to 40 ° C, and further comprises introducing a carbon dioxide into the lactic acid bacteria culture solution. operating. The method for producing a female intimate cleansing agent according to claim 1, wherein the lactic acid bacteria culture solution is cultured in the environment of 30 ° C to 40 ° C, the fermentation promoter is selectively incubated in the lactic acid bacteria culture solution The culture solution is added to the lactic acid bacteria culture solution before the culture at 30 ° C to 40 ° C, or the lactic acid bacteria culture solution is added to the lactic acid bacteria culture solution when the culture medium is cultured at 30 ° C to 40 ° C. The method for producing a female privacy cleaner according to claim 2, wherein the surfactant is selected from an anionic surfactant, a zwitterionic surfactant or Nonionic surfactant. A method of producing a female intimate cleansing agent according to claim 12, wherein the anionic surfactant is selected from the group consisting of sodium lauryl ether sulfate or ammonium lauryl sulfate. The method for producing a female privacy cleaner according to claim 2, wherein the step of adding the surfactant to the lactic acid fermentation broth further comprises the step of filtering the lactic acid fermentation broth. The method for producing a female intimate cleansing agent according to claim 14, wherein the lactic acid bacteria fermentation liquid is filtered through a molecular sieve. The method of manufacturing a female privacy cleaner according to claim 1, wherein one of the female privacy cleaners has a pH between 3.5 and 4.5. The method for manufacturing a female privacy cleaner according to claim 1, further comprising the step of adding an acidic component to the lactic acid fermentation broth to maintain the pH and increase the bacteriostatic effect. A method of producing a female intimate cleansing agent according to claim 17, wherein the acidic component is selected from the group consisting of acetic acid, citric acid or lactic acid. The method for producing a female privacy cleaner according to claim 1, further comprising the step of introducing a hydrogen peroxide to the lactic acid fermentation broth. The method for producing a female privacy cleaner according to claim 1, further comprising the step of combining the female privacy cleaner with an excipient. The method for producing a female intimate cleansing agent according to claim 20, wherein the excipient is selected from the group consisting of a water-soluble polymer, a polymer polysaccharide polymer, water, saline, petroleum jelly, glycerin, glycerin. one of them. The method for producing a female privacy cleaner according to claim 21, wherein the water-soluble polymer is composed of a liquid polyethylene glycol or polyvinyl alcohol and a solid polyethylene glycol or polyvinyl alcohol. Composed of carboxylic acid based cellulose or starch. A female intimate cleansing agent is prepared by the method for manufacturing a female intimate cleansing agent according to claim 1, wherein the female intimate cleansing agent comprises a lactic acid bacteria fermentation liquid having a hydrogen peroxide and a suppressing agent. Phytocin. The female intimate cleansing agent according to claim 23, further comprising a surfactant, wherein the surfactant is added to the lactic acid bacteria fermentation liquid, and the surfactant reacts chemically with the bacteriocin. The feminine privacy cleaner according to claim 24, wherein the surfactant is selected from an anionic surfactant such as sodium lauryl sulfate or ammonium lauryl sulfate, or a zwitterionic surfactant, or a nonionic interface. Active agent. The female intimate cleanser of claim 23 having a pH between 3.5 and 4.5. The female privacy cleaner according to claim 23 further comprises an acidic component. A female intimate cleansing agent according to claim 27, wherein the acidic component is selected from the group consisting of acetic acid, citric acid or lactic acid. The female intimate cleansing agent of claim 23, further comprising an excipient, the lactic acid bacteria fermentation broth and the surfactant being bound to the excipient. The female intimate cleansing agent according to claim 29, wherein the excipient is selected from the group consisting of a water-soluble high molecular polymer, a high molecular polysaccharide polymer, a petroleum jelly, a glycerin, and a glycerin. The female privacy cleaner according to claim 30, wherein the water-soluble polymer is composed of a liquid polyethylene glycol or polyvinyl alcohol and a solid polyethylene glycol, polyvinyl alcohol or starch. . The female intimate cleansing agent according to claim 23, which is in the form of a liquid, a spray, a gel, a capsule, a dry powder, or an emulsion. The female intimate cleansing agent according to claim 23, further comprising a carrier, wherein the lactic acid bacteria fermentation liquid and the surfactant are disposed on the carrier. A feminine privacy cleanser as claimed in claim 33, wherein the carrier is selected from the group consisting of a sanitary napkin, a pad, a wet tissue or a condom. The female intimate cleansing agent according to claim 23 further comprises a colloid which prolongs the time during which the lactic acid bacteria fermentation liquid stays in the skin and the vaginal mucosa to enhance the antibacterial effect. The female intimate cleansing agent of claim 35, wherein the gum system is selected from the group consisting of trisin, carboxymethylcellulose, guar gum or one of them. The female intimate cleansing agent according to claim 23 further comprises a natural essential oil, which can increase the bacteriostatic effect of the lactic acid bacteria fermentation broth. A female intimate cleansing agent according to claim 37, wherein the natural essential oil is selected from the group consisting of sage extract, chamomile extract, calendula extract or thymol, or one of them.