JPH1171251A - Composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To improve the change in viscosity with the storage stability increased with time by formulating an alginic ester of propylene glycol to the composition for oral cavity containing condensed phosphate salt and xanthan gum. SOLUTION: In an oral cavity composition that contains 0.01-15 wt.%, preferably 0.1-10 wt.% of straight or cyclic condensed phosphate salt of the formula: M<1> n+2 Pn O3n-1 , M<2> n Pn O3n-1 , (M<1> PO3 )m . M<2> (PO3 )2 }m (M<1> is monovalent metal, M<2> is a divalent metal and the parts of M<1> and M<2> may be substituted by H; (n) >=2; (m) >=3) as sodium pyrophosphate and 0.01-5 wt.%, preferable 0.05-2 wt.% of xanthan gum, an alginic ester of propylene are formulated, preferably in an amount of 0.01-5 wt.%, preferably 0.1-1 wt.%, in addition, when necessary, an abrasive, a thickener, a surfactant, a sweetener, perfume and a preservative are added thereto.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an oral composition using a condensed phosphate and xanthan gum in more detail. Composition.

[0002]

2. Description of the Related Art Conventionally, oral compositions containing various condensed phosphates as a tartar-preventing component have been proposed, and xanthan gum may be used as a binder in some cases. Kaihei 2-258
No. 11, JP-A-3-200712, JP-A-3-200
719). However, since the viscosity of this composition is greatly reduced with aging at a medium to high temperature, improvement in the change in viscosity has been demanded from the viewpoint of commercial value.

[0003]

Means for Solving the Problems and Embodiments of the Invention The present inventor has conducted intensive studies in order to respond to the above demand, and as a result,
By blending propylene glycol alginate with the oral composition using the condensed phosphate and xanthan gum in combination, the change in viscosity is improved, and the oral composition having good stability over time can be obtained. The present invention has led to the present invention.

Hereinafter, the present invention will be described in more detail.
As described above, the oral composition according to the present invention is obtained by blending propylene glycol alginate in an oral composition using a condensed phosphate and xanthan gum in combination.

[0005] Here, the condensed phosphate includes the following general
Equations (1) to (4) M¹ _{n + 2}P_nO_3n-1 (1) M^Two _nP_nO_3n-1 (2) (M¹ P O_Three)_m (3) ｛M^Two (P O_Three)_Two｝_m (4) (However, M¹Is a monovalent metal, M^TwoRepresents a divalent metal,
M¹, M^TwoMay be substituted with a hydrogen atom.
n and m are n ≧ 2 and m ≧ 3. )
Is used in the form of a ring. Specifically, n = 2 pyro
Phosphate, n = 3 tripolyphosphate, n = 4 tetra
Polyphosphate, high polymerization degree metaphosphate, m = 3
Metaphosphate, tetrametaphosphate with m = 4, m = 6
Hexametaphosphate and the like, and salts (the above M¹,
M^Two) Includes sodium, potassium, calcium,
Zinc and the like. To illustrate, as pyrophosphate
Is sodium pyrophosphate, potassium pyrophosphate, pylori
Calcium phosphate, calcium dihydrogen pyrophosphate, pylori
Examples of the polyphosphate having n ≧ 3 include zinc phosphate and the like.
Sodium polyphosphate and hexametaphosphate
Sodium oxametaphosphate etc.
But sodium pyrophosphate, potassium pyrophosphate, poly
Sodium phosphate is preferred, especially sodium pyrophosphate
Most preferred is the use of aluminum.

[0006] The above-mentioned condensed phosphate is one of these.
A seed may be contained, or two or more kinds may be contained.
These compounds are appropriately compounded and used in various amounts depending on the purpose of each compounding, but usually 0.01 to 15% (% by weight, the same applies hereinafter), particularly 0.1 to 15% of the whole composition.
It can be 10%.

The amount of the xanthan gum to be added is also appropriately selected, but is preferably 0.01 to 5%, more preferably 0.05 to 5% of the whole composition.
It is preferably about 2%.

In the present invention, propylene glycol alginate is blended in the combined system of the above condensed phosphate and xanthan gum. Thereby, the effect of suppressing the decrease in viscosity over time is exhibited. The amount of the propylene glycol alginate is 0.01 to 5%, preferably 0.1 to 5%, of the whole composition. l ~
Preferably, it is 1%. When the amount is less than 0.01%, the effect is not sufficiently exhibited. When the amount is more than 5%, the taste of the food may adversely affect the palatability.

The oral composition according to the present invention can be prepared as toothpaste, toothpaste, liquid dentifrice and the like. In this case, as other components, a commonly used appropriate component, that is, an abrasive , A thickener, a surfactant, a sweetener, a flavor, a preservative, various active ingredients, and the like.

For example, abrasives include dibasic calcium phosphate dihydrate and anhydride, monobasic calcium phosphate,
Tertiary calcium phosphate, calcium carbonate, calcium pyrophosphate, aluminum hydroxide, alumina, silicic acid, aluminum silicate, insoluble sodium metaphosphate, tertiary magnesium phosphate, magnesium carbonate, calcium sulfate, bentonite, zirconium silicate, polymethacrylic acid One or two of methyl, other synthetic resin, etc.
More than one species may be included.

Further, sorbitol, glycerin, ethylene glycol, propylene glycol, 1,
One or more of 3-butylene glycol, polyethylene glycol, polypropylene glycol, xylitol, maltitol, lactitol and the like may be blended.

Further, fragrance components such as menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol,
Citronellyl acetate, cineol, linalool, ethyl linalool, crocodile, thymol, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, cinnamon oil, perilla oil, winter green oil, Flavors such as clove oil and eucalyptus oil may be used alone or in combination, and sweetness such as saccharin sodium, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, perillartin, thaumatin, asparatyl phenylalanine methyl ester, p-methoxycinnamic aldehyde, etc. And the like.

The active ingredient includes enzymes such as dextranase, mutanase, lysozyme, amylase, protease, lytic enzyme and superoxide dismutase, and alkali metal monofluorophosphates such as sodium monofluorophosphate and potassium monofluorophosphate. And sodium fluoride, fluorides such as stannous fluoride, tranexamic acid, epsilon aminocaproic acid,
Aluminum chlorohydroxyallantoin, dihydrocholestanol, glycyrrhizic acids, glycyrrhetinic acid, bisabolol, isopropylmethylphenol, glycerophosphate, chlorophyll, sodium chloride, water-soluble inorganic phosphate compound, triclosan, cetylpyridinium chloride, isopropylmethylphenol, benzalco chloride One or more kinds of active ingredients such as ammonium and benzethonium chloride may be blended.

As the surfactant, an anionic surfactant, a nonionic surfactant and an amphoteric surfactant are used. Examples of the anionic surfactant include sodium alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, and N-lauroyl sarcosine sodium and N-myristoyl sarcosine sodium.
N-acyl glutamates such as sodium acyl sarcosine, sodium dodecyl benzene sulfonate, sodium hydrogenated coconut fatty acid monoglyceride monosulfate, sodium lauryl sulfoacetate, sodium N-palmitoyl glutamate, sodium N-methyl-N-acyl taurate, Sodium methyl-N-acylalanine, sodium α-olefin sulfonate and the like are used.

Examples of the nonionic surfactant include sugar fatty acid esters such as sucrose fatty acid ester, maltose fatty acid ester and lactose fatty acid ester, sugar alcohol fatty acid esters such as maltitol fatty acid ester and lactitol fatty acid ester, and polyoxyethylene sorbitan. Monolaurate, polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monostearate, polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, lauric acid mono- or diethanolamide, fatty acids such as myristic mono- or diethanolamide Diethanolamide, sorbitan fatty acid ester, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene Like polyoxypropylene fatty acid ester is used.

Examples of the amphoteric surfactant include N-alkyldiaminoethylglycine such as N-lauryldiaminoethylglycine and N-myristyldiaminoethylglycine, N-alkyl-N-carboxymethylammonium betaine, and 2-alkyl-1-amine. Hydroxyethylimidazoline betaine sodium is used.

In the present invention, in addition to xanthan gum, other binders, for example, sodium carboxymethylcellulose (CM), as long as the effects of the present invention are not impaired.
C), carrageenan, etc. may be blended.

[0018]

According to the present invention, the decrease in viscosity over time can be improved by blending propylene glycol alginate in an oral composition using a condensed phosphate and xanthan gum in combination.

[0019]

EXAMPLES The present invention will be described in detail below with reference to examples and comparative examples, but the present invention is not limited to the following examples. In addition, all% in each example are weight%.

[Experimental Examples] Toothpastes having the formulations shown in Table 1 were prepared, and the changes in viscosity when stored at 40 ° C. and 50 ° C. for one month were observed. The results are also shown in Table 1.

[0021]

[Table 1]

From the results shown in Table 1, the composition containing xanthan gum and not containing sodium pyrophosphate has a small change in viscosity (No. 1), but the use of xanthan gum and sodium pyrophosphate causes a decrease in viscosity (No. 1). .2). On the other hand, propylene glycol alginate and sodium alginate were further added to 0.1 g.
Even if it is added in an amount less than 01%, the decrease in viscosity is not sufficiently improved (No. 3), but by adding 0.01% or more, the decrease in viscosity is suppressed (Nos. 4, 5) and stable. It was found that the properties were significantly improved.

Example 1 Toothpaste Propylene glycol alginate 0.6% Sodium pyrophosphate 5 Silicic anhydride 10 Propylene glycol 3 Glycerin (85%) 25 Xanthan gum 0.5 Lauroyl sarcosine sodium 0.3 Sodium lauryl sulfate 1 Tranexam Acid 0.05 Sodium fluoride 0.21 Saccharin sodium 0.1 Perfume 1.2 Purified water Balance 100%

Example 2 Toothpaste Propylene glycol alginate 0.2% Sodium pyrophosphate 3 Sodium tripolyphosphate 2 Silicic anhydride 20 Propylene glycol 2 Sorbitol (70%) 30 Xanthan gum 0.8 Carrageenan 0.2 Sodium lauryl sulfate 1.5 Epsilon aminocaproic acid 0.05 Sodium fluoride 0.21 Saccharin sodium 0.2 Perfume 1 Purified water Balance 100%

Example 3 Toothpaste Propylene glycol alginate 0.4% Potassium pyrophosphate 5 Silicic anhydride 15 Propylene glycol 3 Glycerin (85%) 23 CMC 0.2 Xanthan gum 0.6 Sodium lauryl sulfate 1.2 Glycyrrhizin Dipotassium acid 0.05 Sodium fluoride 0.21 Sodium saccharin 0.1 Fragrance 1.3 Purified water Balance 100%

Example 4 Toothpaste Propylene glycol alginate 0.4% Potassium pyrophosphate 3 Sodium tripolyphosphate 2 Dicalcium phosphate 40 Propylene glycol 4 Glycerin (85%) 35 Xanthan gum 0.8 Carrageenan 0.1 Sodium lauryl sulfate 1.8 Dipotassium glycyrrhizinate 0.05 Sodium monofluorophosphate 0.76 Sodium saccharin 0.5 Perfume 0.6 Purified water Balance 100%

Example 5 Toothpaste Propylene glycol alginate 0.8% Sodium pyrophosphate 3 Sodium tripolyphosphate 2 Dicalcium phosphate 35 Propylene glycol 3 Sorbitol (70%) 40 CMC 0.1 Xanthan gum 0.5 Sodium lauryl sulfate 2 Tranexamic acid 0.05 Epsilon aminocaproic acid 0.05 Saccharin sodium 0.15 Fragrance 0.8 Purified water Balance 100%

Example 6 Toothpaste Propylene glycol alginate 0.5% Sodium pyrophosphate 5 Aluminum hydroxide 45 Propylene glycol 2.5 Glycerin (85%) 25 Xanthan gum 0.5 Carrageenan 0.1 Sodium lauroyl sarcosine 0. 1 Sodium lauryl sulfate 1.2 Tranexamic acid 0.05 Triclosan 0.05 Saccharin sodium 0.2 Fragrance 1.5 Purified water Balance 100%

Example 7 Toothpaste Propylene glycol alginate 0.7% Sodium pyrophosphate 4 Sodium tripolyphosphate 1 Calcium carbonate 40 Propylene glycol 3 Glycerin (85%) 20 Xanthan gum 0.3 Carrageenan 0.2 Lauroyl sarcosine sodium 0 1.2 Sodium lauryl sulfate 1.5 Saccharin sodium 0.4 Perfume 1.3 Purified water Balance 100%

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[Procedure amendment]

[Submission date] November 28, 1997

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] 0009

[Correction method] Change

[Correction contents]

The oral composition according to the present invention can be prepared into a toothpaste, a liquid dentifrice and the like. In this case, as other components, appropriate components usually used, that is, an abrasive, a viscous agent ,
Surfactants, sweeteners, flavors, preservatives, various active ingredients and the like can be added.

[Procedure amendment 2]

[Document name to be amended] Statement

[Correction target item name] 0022

[Correction method] Change

[Correction contents]

From the results shown in Table 1, the composition containing xanthan gum and not containing sodium pyrophosphate has a small change in viscosity (No. 1), but the use of xanthan gum and sodium pyrophosphate causes a decrease in viscosity (No. 1). .2). On the other hand, even if propylene glycol alginate is added in an amount of less than 0.01%, the decrease in viscosity is not sufficiently improved (No.
3) By adding 0.01% or more, reduction in viscosity was suppressed (Nos. 4 and 5), and it was recognized that the stability was significantly improved.

Claims (1)

[Claims] 1. An oral composition comprising a condensed phosphate and xanthan gum in combination with propylene glycol alginate.