JP2013119520A - Dentifrice composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a dentifrice composition that ensures sufficient foaming upon brushing of teeth, shows high shelf stability, is excellent in preventing hyperesthesia and comprises potassium nitrate and/or aluminum lactate.SOLUTION: The dentifrice composition comprises (A) potassium nitrate and/or aluminum lactate, (B) an anionic surfactant, (C) at least one water-soluble polymer chosen from xanthan gum, carboxymethylcellulose sodium, sodium polyacrylate, sodium alginate, carrageenan and carboxyvinyl polymer and (D) propylene glycol alginate.

Description

  The present invention relates to a dentifrice composition containing potassium nitrate and / or aluminum lactate. More specifically, the present invention is excellent in preventing hypersensitivity, having sufficient foaming at the time of brushing and having good storage stability. It relates to a dentifrice composition.

To the dentifrice composition, potassium nitrate or aluminum lactate is blended for the purpose of imparting an effect of preventing hypersensitivity.
On the other hand, an anionic surfactant such as sodium lauryl sulfate is usually added to the dentifrice composition to ensure foaming. Various water-soluble polymers are blended as a binder.

  However, the dentifrice composition containing potassium nitrate and aluminum lactate has a problem that foaming during tooth brushing is poor and a sufficient amount of foaming cannot be secured. For this reason, there was a problem that the tooth could not be brushed over time until a sufficient effect was exhibited, and the dentifrice composition could not be spread in the oral cavity. In addition, liquid separation tends to occur over time, and storage stability has also been an issue.

  Patent Document 1 (Japanese Patent Laid-Open No. 2006-96669) and Patent Document 2 (Japanese Patent Laid-Open No. 2005-68071) propose a dentifrice containing potassium nitrate. Patent Document 3 (Japanese Patent Publication No. 2011-513436) and Patent Document 4 (Japanese Patent Publication No. 2009-542705) propose dentifrice compositions and oral care compositions containing xanthan gum as hydrophilic colloids, and potassium nitrate. It is described that an alginate ester (alginate ester) is blended. However, these were insufficient in terms of foaming during tooth brushing and liquid separation stability.

JP 2006-96696 A JP 2005-68071 A Special table 2011-513436 gazette Special table 2009-542705 gazette

  The present invention has been made in view of the above circumstances, solves the above problems in a dentifrice composition containing potassium nitrate and aluminum lactate, has sufficient foaming at the time of brushing, and has good storage stability. An object of the present invention is to provide a dentifrice composition excellent in the effect of preventing hypersensitivity.

  As a result of intensive studies to achieve the above object, the present inventors have found that (A) potassium nitrate and / or aluminum lactate, (B) anionic surfactant, (C) xanthan gum, sodium carboxymethylcellulose, poly By blending one or more water-soluble polymers selected from sodium acrylate, sodium alginate, carrageenan, and carboxyvinyl polymer with (D) propylene glycol alginate, foaming at the time of brushing is sufficiently secured. Furthermore, the present inventors have found that a dentifrice composition with improved liquid separation stability and a high effect of preventing hypersensitivity can be obtained, and has led to the present invention.

That is, when the component (A) is blended in the dentifrice composition, there is a problem that even if the component (B) is blended, there is a problem that the amount of foaming during tooth brushing is small. However, according to the present invention, the components (A) and (B ) To the dentifrice composition containing the components (C) and (D) in combination, the above-mentioned problems can be solved, a sufficient amount of foaming can be secured, and the toothpaste is sufficient for a sufficient amount of time. Can be used to spread the dentifrice composition into the oral cavity. In addition, liquid separation stability over time can be improved.
Potassium nitrate, aluminum lactate, anionic surfactant, the above-mentioned water-soluble polymer, and propylene glycol alginate are each known as a compounding component of a dentifrice composition, but components (A), (B), (C) and components It has been newly found by the present inventors that the amount of foaming in the above-described dentifrice composition is improved by combining (D) and gives the above-mentioned special effects.

Therefore, the present invention
(A) potassium nitrate and / or aluminum lactate,
(B) an anionic surfactant,
(C) one or more water-soluble polymers selected from xanthan gum, sodium carboxymethylcellulose, sodium polyacrylate, sodium alginate, carrageenan, carboxyvinyl polymer,
(D) A dentifrice composition comprising propylene glycol alginate is provided.

  ADVANTAGE OF THE INVENTION According to this invention, the dentifrice composition containing potassium nitrate and / or aluminum lactate which was fully ensured foaming at the time of toothbrushing, and was excellent in the hypersensitivity prevention effect which has favorable storage stability can be provided.

  The present invention will be described in further detail below. The dentifrice composition of the present invention contains (A) potassium nitrate and / or aluminum lactate, (B) an anionic surfactant, (C) a water-soluble polymer, and (D) propylene glycol alginate.

The component (A), potassium nitrate and aluminum lactate, are components for imparting an effect of preventing hypersensitivity, and one of them may be blended alone or in combination of potassium nitrate and aluminum lactate. Commercially available potassium nitrate and aluminum lactate can be used.
The compounding amount of the component (A) is preferably 0.1 to 10% (mass%, the same applies hereinafter) of the entire composition, and more preferably 1 to 7%. If it is less than 0.1%, the hypersensitivity preventing effect may not be satisfactorily imparted. If it exceeds 10%, liquid separation may occur after storage.

(B) Examples of anionic surfactants include alkyl sulfates having 12 to 14 carbon atoms in the alkyl group, such as sodium lauryl sulfate and sodium myristyl sulfate, sodium N-lauroyl sarcosinate, sodium N-myristoyl sarcosinate, etc. N-methyl-N-acyl taurine sodium, sodium N-methyl-N-acylalanine, sodium dodecylbenzenesulfonate, sodium hydrogenated coconut fatty acid monoglyceride monosulfate, sodium lauryl sulfoacetate , Sodium α-olefin sulfonate, sodium N-palmitoyl glutamate, and the like. Among these, sodium lauryl sulfate, sodium lauroyl sarcosine, and sodium lauroylmethyl taurine are suitable for the expression of the effects of the present invention. In particular, sodium lauryl sulfate is more preferable in terms of solubility and usability.
Commercially available anionic surfactants can be used. For example, sodium lauryl sulfate includes Toho Chemical Industries Co., Ltd. and Nikko Chemicals Co., Ltd.

  The content of the (B) anionic surfactant is not particularly limited and may be a normal amount, preferably 0.1 to 3%, particularly preferably 0.2 to 2% of the entire composition. If it is less than 0.1%, the amount of foaming may be inferior. If it exceeds 3%, liquid separation may be deteriorated after storage.

  The water-soluble polymer of component (C) is selected from xanthan gum, sodium carboxymethylcellulose, sodium polyacrylate, sodium alginate, carrageenan, and carboxyvinyl polymer, and these may be used alone or in combination of two or more. . Among these, xanthan gum can be preferably used because it is excellent in moldability and oral dispersibility during preparation of a dentifrice. In this case, xanthan gum and one or more selected from sodium carboxymethylcellulose, sodium polyacrylate, sodium alginate, carrageenan, and carboxyvinyl polymer may be combined in terms of effect.

As a xanthan gum of a component (C), the thing whose viscosity measured using the B-type viscometer is 500-3,000 mPa * s is preferable, and what is especially 1,000-2,000 mPa * s is more preferable.
The viscosity is a value obtained by measuring a 1% xanthan gum aqueous solution (containing 1% potassium chloride) with a B10H viscometer (rotor No. 3, rotation speed: 60 rpm, measurement time: 30 seconds, 25 ° C.).

  A commercial item can be used for a component (C). Specifically, as xanthan gum, trade name Monato Gum DA (manufactured by DSP Gokei Food & Chemical Co., Ltd.), as carboxymethyl cellulose sodium, trade name CMC Daicel (manufactured by Daicel Finechem Co., Ltd.), as sodium polyacrylate, product Name Leogic 250-H (manufactured by Toa Gosei Co., Ltd.), trade name as sodium alginate The product name includes Carbopol 980 (manufactured by Lubrizol Corporation).

  The amount of component (C) is preferably 0.1 to 3%, more preferably 0.2 to 2% of the total composition. If it is less than 0.1%, liquid separation may occur after storage. If it exceeds 3%, the skin may become worse after storage.

A commercially available thing can be used for the propylene glycol alginate of a component (D), for example, Kimiloid BF (made by Kimika Co., Ltd.) etc. are mentioned.
The blending amount of component (D) propylene glycol alginate is preferably 0.05 to 3%, more preferably 0.1 to 2% of the total composition. If it is less than 0.05%, foaming at the time of brushing may be inferior. If it exceeds 3%, liquid separation may occur after storage.

In the present invention, it is important to use the component (C) and the component (D) together in order to improve the amount of foaming when brushing teeth and to ensure the stability of liquid separation, and the component (C) or the component (D) If it is absent, the amount of foaming is small, and the liquid separation stability is poor.
In this case, it is more suitable for effect expression that a component (C) and a component (D) are an appropriate ratio. Component (C) / component (D) is preferably in the range of 0.2 to 20, more preferably 0.3 to 10 as the mass ratio. If it is less than 0.2, liquid separation may occur after storage. If it exceeds 20, foaming during brushing may be inferior.

  The dentifrice composition of the present invention is suitably prepared as a toothpaste, a liquid toothpaste, a liquid toothpaste, a moistened toothpaste and the like, particularly as a toothpaste. In this case, in addition to the above components, other known components can be added as necessary. Examples thereof include abrasives, surfactants, wetting agents, binders, fragrances, pigments, pH adjusters, sweeteners, preservatives, and various active ingredients.

  As abrasives, silica-based abrasives such as silica gel, precipitated silica, aluminosilicate, zirconosilicate, calcium pyrophosphate, calcium carbonate, aluminum hydroxide, alumina, magnesium carbonate, tribasic magnesium phosphate, zeolite, zirconium silicate, Examples thereof include hydroxyapatite and synthetic resin abrasives (the amount is usually 5 to 50%).

  As the surfactant, a nonionic surfactant, a cationic surfactant, and an amphoteric surfactant can be blended. Specific examples are as follows.

Nonionic surfactant:
Sugar alcohol fatty acid esters such as sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sucrose fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyhydric alcohol fatty acid ester such as polyethylene glycol fatty acid ester , Polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene alkylphenyl ether, ether type activator such as polyoxyethylene hydrogenated castor oil, fatty acid alkanolamides such as lauric acid diethanolamide cationic Surfactant:
Distearylmethylammonium chloride, stearyldimethylbenzylammonium chloride amphoteric surfactant:
N-alkyldiaminoethylglycine such as 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine, N-lauryldiaminoethylglycine, N-myristyldiaminoethylglycine or N-alkyl-1-hydroxyethylimidazoline betaine sodium The blending amount of these surfactants is preferably in the range where the total amount including the component (B) is 0.1 to 10%.

  Examples of wetting agents include sugar alcohols such as sorbitol, xylitol, erythritol, reduced starch saccharified product, propylene glycol, pentylene glycol, hexylene glycol, octylene glycol, polyethylene glycol having a molecular weight of 200 to 6,000, ethylene glycol, Examples include polyhydric alcohols such as 1,3-butylene glycol and glycerin (the amount is usually 0.1 to 50%).

  As a binder, you may mix | blend well-known binders other than a component (C) and (D) in the range which does not prevent the effect of this invention. Examples thereof include cellulose-based binders such as hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxymethylethylcellulose, methylcellulose, and cationized cellulose, and inorganic binders such as montmorillonite and gelatin (the blending amounts are components (C) and ( The range of 0.15 to 6% including D) is preferred.)

  As the fragrance, commonly used fragrances such as menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineol, linalool, ethyl linalool, vanillin, thymol, spearmint oil, Peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, cinnamon oil, perilla oil, winter green oil, clove oil, eucalyptus oil and the like.

  Examples of the dye include legal dyes such as Blue No. 1, Blue No. 4, and Green No. 3, natural dyes such as caramel, and titanium oxide.

Examples of the pH adjuster include organic compounds such as citric acid, lactic acid and malic acid and salts thereof, and inorganic compounds such as hydrochloric acid, sodium hydroxide, potassium hydroxide, disodium hydrogen phosphate and sodium dihydrogen phosphate. .
Sweeteners include sodium saccharin, aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, and perilartin. Sodium etc. are mentioned.

  Various active ingredients include enzymes such as dextranase, amylase, protease, mutanase, alkali metal monofluorophosphates such as sodium monofluorophosphate, fluorides such as sodium fluoride and stannous fluoride, tranexamic acid, Anti-inflammatory agents such as epsilon aminocaproic acid, aluminum chlorohydroxy allantoin, azulene, glycyrrhizinate, glycyrrhetinic acid, sodium chloride, vitamins, bactericides such as cetylpyridinium chloride, benzalkonium chloride, triclosan, hinokitiol, lysozyme chloride, polyline Examples include tartar preventive agents such as acid salts, tobacco spider removers such as polyvinylpyrrolidone, and amino acids such as glycine and proline.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified.

In addition, the detail of the used raw material is as follows.
-Potassium nitrate: food additive ST potassium nitrate (trade name) [manufactured by Otsuka Chemical Co., Ltd.]
Aluminum lactate: Aluminum lactate (trade name) [Musashino Chemical Laboratory Co., Ltd.]
・ Sodium lauryl sulfate: ALSCOPE LN (trade name) [manufactured by Toho Chemical Co., Ltd.]
・ Lauroylmethyl taurine sodium: NIKKOL LMT (trade name) [manufactured by Nikko Chemicals Co., Ltd.]
・ Lauroyl sarcosine sodium: Soypon SLP (trade name) [manufactured by Kawaken Fine Chemical Co., Ltd.]
Xanthan gum: Monato gum DA (trade name) [DSP Gokei Food & Chemical Co., Ltd., viscosity ^* ; 1,466 mPa · s]
*; Using a B10H type viscometer (TVB10H type viscometer, Toki Sangyo Co., Ltd.), rotor No. 3, rotation speed: 60 rpm, measurement time: viscosity of 1% xanthan gum aqueous solution (containing 1% potassium chloride) measured at 25 ° C. for 30 seconds: sodium carboxymethylcellulose:
Sodium carboxymethyl cellulose: CMC Daicel (trade name) [Daicel Finechem Co., Ltd.]
-Sodium polyacrylate: Rheology 250-H (trade name) [manufactured by Toa Gosei Co., Ltd.]
・ Sodium alginate: Kimika Argin (trade name) [Kimika Co., Ltd.]
・ Carrageenan: Carrageenan CF02 (trade name) [manufactured by Sanki Co., Ltd.]
・ Carboxyvinyl polymer:
Carbopol 980 (trade name) [Lubrisol Co., Ltd.]
・ Propylene glycol alginate: Kimiloid BF (trade name) [Kimika Co., Ltd.]

[Examples and Comparative Examples]
Dentifrice compositions (toothpaste) having the compositions shown in Tables 1 to 6 were prepared by a conventional method and evaluated by the following methods. The results are shown in Tables 1-6.

(1) Evaluation of the hypersensitivity prevention effect It evaluated by the sensory test using 10 persons with a hypersensitivity symptom. Place a test dentifrice composition of about 1.5cm on a toothbrush, and usually use it for about 4 weeks (twice a day) by brushing the teeth, and evaluate the state of hypersensitivity symptoms after 4 weeks according to the following criteria. did.
Score criteria 3 points: No pain due to hypersensitive symptoms, and symptoms improved.
2 points: Slightly perceived pain due to hypersensitive symptoms, but symptoms improved compared to before use
It was.
1 point: Pain due to hypersensitivity symptom is felt as before and there is no improvement in symptom.
The score results of 10 people were averaged and evaluated according to the following evaluation criteria. Those with ◎ and ○ were judged to be dentifrice compositions capable of suppressing hypersensitivity symptoms and obtaining a preventive effect.
Evaluation criteria for the effect of preventing hypersensitivity ◎: 2.5 to 3.0 points ○: 2.0 to less than 2.5 points △: 1.5 to less than 2.0 points ×: Less than 1.5 points

(2) Evaluation of foaming at the time of tooth brushing It evaluated by the sensory test using ten expert panelists. A test dentifrice composition of about 1.5 cm is placed on a toothbrush, and it is usually used for about 1 week (twice a day) by brushing teeth, and foaming in the oral cavity during brushing is evaluated according to the following evaluation criteria. .
Score criteria 4 points: Sufficient amount of foaming.
3 points: The amount of foaming is moderate.
2 points: Less foaming.
1 point: Almost no foaming.
The score results of 10 people were averaged and shown by the following criteria, and those with 及 び and ○ were judged to be dentifrice compositions that ensured foaming at the time of brushing and provided satisfactory use feeling.
Evaluation criteria for foaming in the oral cavity ◎: 3.5 to 4.0 points ○: 3.0 to less than 3.5 points △: 2.0 to less than 2.5 points ×: 2.0 points Less than

(3) Evaluation of liquid separation stability of the formulation After storing each of the three test dentifrice compositions filled in an 8 mm diameter laminated tube at 50 ° C. for one month, the dentifrice composition was extruded 10 cm onto a straw half paper. The length of the liquid that exudes to the straw half paper was measured, and the degree of liquid separation was evaluated in the following four stages. The liquid separation stability of the preparation tended to promote liquid separation depending on the temperature, and 50 ° C. was selected as a storage temperature that can be evaluated in a storage period of one month.
Score criteria 4 points: No liquid separation is observed.
3 points: When extruded, liquid separation is slightly observed at the mouth, but there is no problem in use.
2 points: When extruded, 1 to 3 cm of liquid separation is observed at the mouth.
1 point: When extruded, liquid separation is recognized in the mouth part over 3 cm.
The average value of the three evaluation points was determined, and the degree of liquid separation was determined in the following four stages. The samples with ◎ and ○ were judged to be dentifrice compositions having excellent liquid separation stability when stored at 50 ° C.
◎: 3.5 points or more and 4.0 points or less ○: 3.0 points or more and less than 3.5 points △: 2.0 points or more and less than 3.0 points ×: Less than 2.0 points

Claims (3)

(A) potassium nitrate and / or aluminum lactate,
(B) an anionic surfactant,
(C) one or more water-soluble polymers selected from xanthan gum, sodium carboxymethylcellulose, sodium polyacrylate, sodium alginate, carrageenan, carboxyvinyl polymer,
(D) A dentifrice composition comprising propylene glycol alginate.   (C) / (D) is 0.2-20 as mass ratio, The dentifrice composition of Claim 1 characterized by the above-mentioned.   (B) The dentifrice composition according to claim 1 or 2, wherein the anionic surfactant is one or more selected from sodium lauryl sulfate, sodium lauroylmethyl taurate, and sodium lauroyl sarcosine.