CN100417373C - Multifunctional enzyme-supplemented colorful toothpaste and preparation method thereof - Google Patents
Multifunctional enzyme-supplemented colorful toothpaste and preparation method thereof Download PDFInfo
- Publication number
- CN100417373C CN100417373C CNB2006100120085A CN200610012008A CN100417373C CN 100417373 C CN100417373 C CN 100417373C CN B2006100120085 A CNB2006100120085 A CN B2006100120085A CN 200610012008 A CN200610012008 A CN 200610012008A CN 100417373 C CN100417373 C CN 100417373C
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- Prior art keywords
- enzyme
- mastic
- toothpaste
- sodium
- water
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- 239000000606 toothpaste Substances 0.000 title claims abstract description 72
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 70
- 238000002360 preparation method Methods 0.000 title claims abstract description 28
- 102000004190 Enzymes Human genes 0.000 claims abstract description 121
- 108090000790 Enzymes Proteins 0.000 claims abstract description 121
- 239000000126 substance Substances 0.000 claims abstract description 20
- 239000000654 additive Substances 0.000 claims abstract description 19
- 239000003086 colorant Substances 0.000 claims abstract description 18
- 239000003248 enzyme activator Substances 0.000 claims abstract description 15
- 239000003381 stabilizer Substances 0.000 claims abstract description 15
- 238000000034 method Methods 0.000 claims abstract description 4
- 229940088598 enzyme Drugs 0.000 claims description 114
- 239000013521 mastic Substances 0.000 claims description 103
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 51
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 33
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 33
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 22
- -1 sarcosyl Chemical compound 0.000 claims description 22
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 20
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 20
- 239000000080 wetting agent Substances 0.000 claims description 20
- 239000004365 Protease Substances 0.000 claims description 19
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 18
- 230000000996 additive effect Effects 0.000 claims description 18
- 239000000600 sorbitol Substances 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 17
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 15
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 15
- 235000002639 sodium chloride Nutrition 0.000 claims description 15
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 15
- 239000004094 surface-active agent Substances 0.000 claims description 15
- 239000002562 thickening agent Substances 0.000 claims description 14
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 claims description 12
- 150000003839 salts Chemical class 0.000 claims description 11
- 239000004408 titanium dioxide Substances 0.000 claims description 11
- 239000004382 Amylase Substances 0.000 claims description 10
- 102000013142 Amylases Human genes 0.000 claims description 10
- 108010065511 Amylases Proteins 0.000 claims description 10
- 108010004032 Bromelains Proteins 0.000 claims description 10
- 102000016938 Catalase Human genes 0.000 claims description 10
- 108010053835 Catalase Proteins 0.000 claims description 10
- 108010015776 Glucose oxidase Proteins 0.000 claims description 10
- 239000004366 Glucose oxidase Substances 0.000 claims description 10
- 102000004882 Lipase Human genes 0.000 claims description 10
- 108090001060 Lipase Proteins 0.000 claims description 10
- 239000004367 Lipase Substances 0.000 claims description 10
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 10
- 102000016943 Muramidase Human genes 0.000 claims description 10
- 108010014251 Muramidase Proteins 0.000 claims description 10
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims description 10
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 10
- 239000002202 Polyethylene glycol Substances 0.000 claims description 10
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 10
- 239000004141 Sodium laurylsulphate Substances 0.000 claims description 10
- 102000019197 Superoxide Dismutase Human genes 0.000 claims description 10
- 108010012715 Superoxide dismutase Proteins 0.000 claims description 10
- 235000019418 amylase Nutrition 0.000 claims description 10
- 235000019835 bromelain Nutrition 0.000 claims description 10
- 238000005516 engineering process Methods 0.000 claims description 10
- 235000019420 glucose oxidase Nutrition 0.000 claims description 10
- 229940116332 glucose oxidase Drugs 0.000 claims description 10
- 235000019421 lipase Nutrition 0.000 claims description 10
- 235000010335 lysozyme Nutrition 0.000 claims description 10
- 239000004325 lysozyme Substances 0.000 claims description 10
- 229960000274 lysozyme Drugs 0.000 claims description 10
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 10
- 229920001223 polyethylene glycol Polymers 0.000 claims description 10
- 239000000377 silicon dioxide Substances 0.000 claims description 10
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 10
- 108091005804 Peptidases Proteins 0.000 claims description 9
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims description 9
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 9
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 9
- 235000011007 phosphoric acid Nutrition 0.000 claims description 9
- 235000019419 proteases Nutrition 0.000 claims description 9
- 239000002994 raw material Substances 0.000 claims description 9
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 9
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 9
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 8
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 8
- 239000000049 pigment Substances 0.000 claims description 8
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 8
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 8
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 7
- 229940072056 alginate Drugs 0.000 claims description 7
- 235000010443 alginic acid Nutrition 0.000 claims description 7
- 229920000615 alginic acid Polymers 0.000 claims description 7
- 235000015110 jellies Nutrition 0.000 claims description 7
- 239000008274 jelly Substances 0.000 claims description 7
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims description 6
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 6
- ZIALXKMBHWELGF-UHFFFAOYSA-N [Na].[Cu] Chemical compound [Na].[Cu] ZIALXKMBHWELGF-UHFFFAOYSA-N 0.000 claims description 6
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 6
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical compound C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 claims description 6
- 235000010333 potassium nitrate Nutrition 0.000 claims description 6
- 239000004323 potassium nitrate Substances 0.000 claims description 6
- 235000012239 silicon dioxide Nutrition 0.000 claims description 6
- 229960004711 sodium monofluorophosphate Drugs 0.000 claims description 6
- 229910001631 strontium chloride Inorganic materials 0.000 claims description 6
- AHBGXTDRMVNFER-UHFFFAOYSA-L strontium dichloride Chemical compound [Cl-].[Cl-].[Sr+2] AHBGXTDRMVNFER-UHFFFAOYSA-L 0.000 claims description 6
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 5
- 239000001888 Peptone Substances 0.000 claims description 5
- 108010080698 Peptones Proteins 0.000 claims description 5
- UHCRRGVTSMNUQA-UHFFFAOYSA-N [Cu].[S].OC1=NC=CC=C1 Chemical compound [Cu].[S].OC1=NC=CC=C1 UHCRRGVTSMNUQA-UHFFFAOYSA-N 0.000 claims description 5
- FENRSEGZMITUEF-ATTCVCFYSA-E [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] FENRSEGZMITUEF-ATTCVCFYSA-E 0.000 claims description 5
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 5
- 239000001110 calcium chloride Substances 0.000 claims description 5
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 5
- 235000010418 carrageenan Nutrition 0.000 claims description 5
- 239000000679 carrageenan Substances 0.000 claims description 5
- 229920001525 carrageenan Polymers 0.000 claims description 5
- 229940113118 carrageenan Drugs 0.000 claims description 5
- 239000010977 jade Substances 0.000 claims description 5
- 229910001629 magnesium chloride Inorganic materials 0.000 claims description 5
- 235000019319 peptone Nutrition 0.000 claims description 5
- 229920000136 polysorbate Polymers 0.000 claims description 5
- 229940083982 sodium phytate Drugs 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 5
- 239000001736 Calcium glycerylphosphate Substances 0.000 claims description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 4
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 4
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 4
- 229910021502 aluminium hydroxide Inorganic materials 0.000 claims description 4
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 claims description 4
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 4
- UHHRFSOMMCWGSO-UHFFFAOYSA-L calcium glycerophosphate Chemical compound [Ca+2].OCC(CO)OP([O-])([O-])=O UHHRFSOMMCWGSO-UHFFFAOYSA-L 0.000 claims description 4
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- 239000001508 potassium citrate Substances 0.000 claims description 4
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- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims description 4
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- 239000001963 growth medium Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000005829 trimerization reaction Methods 0.000 description 1
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Landscapes
- Cosmetics (AREA)
Abstract
The present invention relates to a multifunctional color bar enzymatic toothpaste and a preparation method thereof. The toothpaste is composed of a regulative toothpaste body in one color and an enzyme-containing toothpaste body in various colors, wherein the regulative toothpaste body comprises chemical medicine additives and biological enzyme activators, and the enzyme-containing toothpaste body comprises biological enzymes and biological enzyme stabilizing agents. The preparation method is that the regulative toothpaste body and the enzyme-containing toothpaste body are respectively prepared, and are canned to form the color bar toothpaste. The color bar multienzyme toothpaste has the efficacy of the multiplex prevention and treatment for buccal problems, such as preventing and treating dental caries, diminishing inflammation, sterilization, desensitization, refreshing breath, whitening teeth, etc., and simultaneously, the stabilizing agents and the color bars are used for ensuring the stability of the enzymatic toothpaste, and certain activators are added to effectively exert biological function of the enzymes in the release procedure of the enzymes.
Description
Technical field
The present invention relates to a kind of toothpaste, more particularly, relate to a kind of striped toothpaste that contains multiple enzyme.
Background technology
In oral disease, dental caries and periodontal disease are to cause the main cause of absence of tooth.Have result of study to prove: the Streptococcus mutans that causes dental caries is grown on the culture medium that contains sucrose can produce glucosan, and observes the enrichment phenomenon of Streptococcus mutans simultaneously.Glucosan is a kind of colloidal substance of viscosity, and it can make multiple pathogen assemble, and forms bacterial plaque on tooth.And the organic acid that produces sour pathogen generation can cause enamel decalcification, and then forms dental caries.
In order to prevent and treat dental caries, generally in the prior art adopt two kinds of methods, a kind of is pharmaceutical preparation, but has many unfavorable factors such as drug resistance, another kind is to use biologically active agents.In recent years, many scientists and medical personnel add in the toothpaste with multiple compound enzymic preparation, have obtained good effect for treatment bacterial plaque and dental caries.
Toothpaste has experienced the variation of decades as the necessary of daily life.Along with human living standard's raising, everybody is also more and more higher to the requirement of toothpaste, and along with reaching its maturity of biotechnology, biological enzyme toothpaste has become a popular research.
At present, external particularly Japan is making number of research projects aspect the research that contains the enzyme biological toothpaste, a lot of relevant patents have also been delivered, as Japan Patent JP2000 63251, JP2001 302481, and JP2001 342123, and JP2002 20254, JP96310931, JP97 25221 grades disclose some enzyme-containing toothpastes.And enzyme-containing toothpaste also is in the exploratory stage in China, the present domestic patent that some enzyme-containing toothpastes also occur, and as CN 1366875A, CN 1720891A, CN 1688282A, CN 1190579A.Comprehensive enzyme-containing toothpaste both at home and abroad, on the whole, the kind that toothpaste contains enzyme is more single, and function is relatively single, and the activity of enzyme and stability can not well be ensured.
Enzyme stable poor, various enzyme all have the specified conditions of its stable existence.In toothpaste, add enzyme, should ensure the stable of lotion of toothpaste, guarantee biological enzyme activity and stability again, existing enzyme-containing toothpaste major part is that various raw materials and enzyme are lumped together, canned then in flexible pipe, because the condition of various enzyme stable existences is closely not identical, be difficult to guarantee that various enzymes can both stable existence in the single mastic so multiple enzyme is added on.And the striped toothpaste technology that occurs at present is except the appearance novelty, attractive in appearance outside, the unique distinction on but outstanding its functional design.
Summary of the invention
The object of the present invention is to provide a kind of multifunctional enzyme-supplemented colorful toothpaste and preparation method thereof, make it both have appearance novelty, attractive in appearance, ensure the stable of lotion of toothpaste, guarantee biological enzyme activity and stability again, thereby reach multiple effect of preventing and treating oral disease.
The objective of the invention is to be achieved through the following technical solutions:
A kind of multifunctional enzyme-supplemented colorful toothpaste, it is characterized in that: this toothpaste is made up of a kind of adjusting mastic of color and the enzyme mastic that contains of multiple color, contain chemicals additive and enzyme activator in the described adjusting mastic, contain enzyme and enzyme stabilizing agent described containing in the enzyme mastic, the component of described adjusting mastic and weight percent content are:
Wetting agent 20～73%
Abrasivus 15～50%
Thickening agent 1～1.7%
Surfactant 1.7～2.5%
Essence 0.8～1.2%
Water 8～35%
Glucide 0.1～0.3%
Pigment 0～0.5%
Polyethylene Glycol 0～6%
Chemicals additive 0.03～5%
Mentholum 0～0.1%
Sodium dihydrogen phosphate 0～0.5%
Titanium dioxide 0～1%
Enzyme activator 0.1～1%
Described every kind of component and weight percent content that contains the enzyme mastic is:
Wetting agent 20～73%
Abrasivus 15～50%
Thickening agent 1～1.7%
Surfactant 1～6%
Essence 0.8～1.2%
Water 8～35%
Glucide 0.1～0.3%
Pigment 0～0.5%
Polyethylene Glycol 0～6%
Enzyme 0.01～2%
Mentholum 0～0.1%
Sodium dihydrogen phosphate 0.1～0.5%
Titanium dioxide 0～1%
Enzyme stabilizing agent 0.1～4%
Described enzyme is glucanase, lysozyme, protease, glucose oxidase, amylase, superoxide dismutase, catalase, lipase, carase or bromelain; In described amylase, glucose oxidase, glucanase, the carase one or more are added in a kind of color mastic; In described lysozyme, protease, catalase, the bromelain one or more are added in the mastic of another kind of color; In described superoxide dismutase, the lipase one or both are added in the mastic of other color; Described chemicals additive is one or more in sodium monofluorophosphate, sodium fluoride, tertiary sodium phosphate, tetrasodium pyrophosphate, potassium pyrophosphate, potassium nitrate, carbamide, sodium phytate, strontium chloride, pure as jade pure, sodium copper chlorophllin, sodium chloride, zinc citrate, potassium citrate, the calcium glycerophosphate.Enzyme stabilizing agent of the present invention is one or more in pyridone sulfur copper and salt thereof, tween, span, peptone, the gelatin; Described enzyme activator is one or more in manganese chloride, calcium chloride, magnesium chloride, taurine, glycine, the aspartic acid.
Wetting agent of the present invention is one or more in sorbitol, glycerol, propylene glycol, the diethylene glycol.Described surfactant is that sodium lauryl sulphate, sarcosyl, imidazoline are one or more in both sexes interfacial agent, polyoxyethanyl ether phosphoric acid and salt thereof, two polyoxy vinyl alkyl ether phosphoric acids and salt thereof, the polyoxyethanyl ether tripolyphosphate.Described abrasivus is one or more in calcium carbonate, silicon dioxide, aluminium hydroxide, the calcium hydrogen phosphate.Described thickening agent is one or more in sodium carboxymethyl cellulose, carrageenan, HEC, HANSHENGJIAO, alginate jelly, card ripple, the aluminium-magnesium silicate.
The invention provides a kind of preparation method of above-mentioned multifunctional enzyme-supplemented colorful toothpaste, it is characterized in that this method comprises the steps:
1) mastic is regulated in preparation: first with the sorbitol in the wetting agent according to the percentage by weight of described adjusting mastic, raw material, chemicals additive mix homogeneously soluble in water in water and the component, add glycerol, propylene glycol or diethylene glycol and mixtures of thickening agents in the wetting agent then, add chemicals additive not soluble in water at last, the enzyme activator, abrasivus, surfactant and other raw material not soluble in water are made a kind of mastic of color;
2) the preparation different colours contain the enzyme mastic: the pH scope with the enzyme stable existence is divided into following three classes with described enzyme:
A. amylase, glucose oxidase, glucanase and carase,
B. lysozyme, protease, catalase and bromelain,
C. superoxide dismutase and lipase;
Contain the enzyme mastic with what above-mentioned three class enzyme were made different colours respectively, each preparation technology who contains the enzyme mastic is identical, concrete preparation technology is as follows: according to the described percentage by weight that contains the enzyme mastic earlier with the sorbitol in the wetting agent, water and raw material mix homogeneously soluble in water add glycerol, propylene glycol or diethylene glycol in the wetting agent and the mixture of thickening agent and enzyme then; Add enzyme stabilizing agent, abrasivus, surfactant and other raw material not soluble in water at last, stir and outgas, make and contain the enzyme mastic;
3) fill: the adjusting mastic that will prepare and contain the enzyme mastic and be filled to together in the Flexible tube for toothpaste, promptly make multifunctional enzyme-supplemented colorful toothpaste.
The present invention compared with prior art, have the following advantages and the salience effect: in design, this multifunctional enzyme-supplemented colorful toothpaste has comprised and has contained the enzyme mastic and regulate mastic, can guarantee the optimum state when various enzymes exist in the toothpaste stability requirement and enzyme discharge effectively, overcome the drawback of existing toothpaste with enzyme, and can give good outward appearance.On function, the combined effect of multiple enzyme and chemicals additive in the toothpaste makes this kind colour bar multienzyme toothpaste have multiple effect of preventing and treating oral problem again, as prevents and treats dental caries, anti-inflammation and sterilization, desensitization, fresh breath, functions such as tooth-whitening.
The specific embodiment
This toothpaste is made up of two class mastic, has wherein added chemicals additive and enzyme activator in the class mastic, is referred to as to regulate mastic; Add enzyme and enzyme stabilizing agent in the another kind of mastic, be referred to as to contain the enzyme mastic.Then with a kind of adjusting mastic of color and one or more colors contain the enzyme mastic together fill become striped toothpaste.The component of described adjusting mastic and weight percent content are:
Wetting agent (sorbitol, glycerol, propylene glycol, diethylene glycol): 20～73%
Abrasivus (calcium carbonate, silicon dioxide, aluminium hydroxide, calcium hydrogen phosphate): 15～50%
Thickening agent (sodium carboxymethyl cellulose, carrageenan, HEC, HANSHENGJIAO, alginate jelly, card ripple, aluminium-magnesium silicate etc.):
1～1.7％
(sodium lauryl sulphate, sarcosyl, imidazoline are both sexes interfacial agent, polyoxyethanyl ether phosphoric acid and salt thereof, two polyoxy vinyl alkyl ether phosphoric acids and salt thereof, polyoxyethanyl ether trimerization to surfactant
Phosphoric acid etc.): 1.7～2.5%
Essence: 0.8～1.2%
Water: 8～35%
Glucide: 0.1～0.3%
Pigment (light blue, D C Yellow No. 10, lemon yellow, yellow 6#, green 6#, red 28#, red 43#, red 40#):
0～0.5％
Polyethylene Glycol: 0～6%
Chemicals additive: 0.03～5%
Mentholum: 0～0.1%
Sodium dihydrogen phosphate: 0～0.5%
Titanium dioxide: 0～1%
Enzyme activator: 0.1～1%
The another kind of enzyme mastic that contains is made the mastic of different colours respectively by the stability requirement of enzyme, and the component of every kind of mastic and weight percent content are:
Wetting agent (sorbitol, glycerol, propylene glycol, diethylene glycol): 20～73%
Abrasivus (calcium carbonate, silicon dioxide, aluminium hydroxide, calcium hydrogen phosphate): 15～50%
Thickening agent (sodium carboxymethyl cellulose, carrageenan, HEC, HANSHENGJIAO, alginate jelly, card ripple, aluminium-magnesium silicate etc.):
1～1.7％
Surfactant (sodium lauryl sulphate, sarcosyl, imidazoline are both sexes interfacial agent, polyoxyethanyl ether phosphoric acid and salt thereof, two polyoxy vinyl alkyl ether phosphoric acids and salt, polyoxyethanyl ether trimer acid etc.): 1～6%
Essence: 0.8～1.2%
Water: 8～35%
Glucide: 0.1～0.3%
Pigment (light blue, D C Yellow No. 10, lemon yellow, yellow 6#, green 6#, red 28#, red 43#, red 40#):
0～0.5％
Polyethylene Glycol: 0～6%
Mentholum: 0～0.1%
Sodium dihydrogen phosphate: 0～0.5%
Titanium dioxide: 0～1%
Enzyme stabilizing agent: 0.1～4%
Enzyme: 0.01～2%
The enzyme that adds in toothpaste is a lysozyme, glucanase, protease, amylase, glucose oxidase, superoxide dismutase, catalase, lipase, carase or bromelain, above-mentioned enzyme is classified according to the requirement of its stable existence condition, mainly divide with the pH scope of enzyme stable existence, be divided three classes altogether: 1) the pH scope is 3.0-7.0: amylase, glucose oxidase, glucanase, carase, 2) the pH scope is 6-7: lysozyme, protease, catalase, bromelain, 3) the pH scope is 6-10.5: superoxide dismutase, lipase.The chemicals additive can be one or more in sodium monofluorophosphate, sodium fluoride, tetrasodium pyrophosphate, potassium pyrophosphate, potassium nitrate, carbamide, sodium phytate, strontium chloride, pure as jade pure, sodium copper chlorophllin, sodium chloride, zinc citrate, potassium citrate, the calcium glycerophosphate, the enzyme and the chemicals additive that have difference in functionality by interpolation, can reach multiple effect of preventing and treating oral disease, as preventing and treating effects such as dental caries, fresh breath, anti-inflammation and sterilization, desensitization, tooth-whitening.The enzyme stabilizing agent can guarantee when being added in the mastic that various enzyme can both stable existence, as pyridone sulfur copper and salt thereof, tween, span, peptone, gelatin.The enzyme activator can improve biological enzyme activity, as manganese chloride, calcium chloride, magnesium chloride, the acid of cattle semi-annular jade pendant, glycine, aspartic acid.
Preparation method of the present invention is as follows:
Adopt the striped toothpaste technology: when preparation contains the enzyme mastic, in the classified same class enzyme one or more are added in the colour bar of same color, and according to the characteristic of enzyme, select other toothpaste compositions and enzyme stabilizing agent, to guarantee the condition of various enzyme stable existences; When mastic is regulated in preparation, chemicals additive and enzyme activator have been added.Then a kind of adjusting mastic of color and one or more colors are contained the canned together striped toothpaste that becomes of enzyme mastic.When striped toothpaste used, the enzyme activator can improve biological enzyme activity, can improve the effect that enzyme is prevented and treated odontopathy.
The multifunctional enzyme-supplemented colorful toothpaste preparation method mainly comprises following step:
Mastic is regulated in the first step, preparation, concrete preparation technology is as follows: at first, according to above-mentioned percentage by weight the sorbitol in the wetting agent and Polyethylene Glycol, water, glucide, chemicals additive (sodium monofluorophosphate, potassium nitrate, sodium phytate, sodium copper chlorophllin, sodium chloride etc.) soluble in water, sodium dihydrogen phosphate, pigment etc. are stirred; Then, according to glycerol or propylene glycol and diethylene glycol and mixtures of thickening agents in the above-mentioned percentage by weight adding wetting agent; At last add chemicals additive not soluble in water (sodium fluoride, tertiary sodium phosphate, tetrasodium pyrophosphate, potassium pyrophosphate, carbamide, sodium phytate, strontium chloride, pure as jade pure, zinc citrate, potassium citrate, calcium glycerophosphate etc.) and enzyme activator, abrasivus, surfactant, titanium dioxide, essence, Mentholum etc. according to above-mentioned percentage by weight, stir and outgas, make mastic.
Second step, preparation different colours contain the enzyme mastic, each preparation technology who contains the enzyme mastic is identical, concrete preparation technology is as follows: at first, according to above-mentioned percentage by weight the sorbitol in the wetting agent and Polyethylene Glycol, water, glucide, sodium dihydrogen phosphate, pigment etc. are stirred; Then, the mixture that adds glycerol in the wetting agent or propylene glycol and diethylene glycol and thickening agent, enzyme according to above-mentioned percentage by weight; Add enzyme stabilizing agent, abrasivus, surfactant, titanium dioxide, essence, Mentholum etc. according to above-mentioned percentage by weight at last, stir and outgas, make mastic.
The 3rd step, fill with the adjusting mastic for preparing with contain the enzyme mastic and be filled to together in the Flexible tube for toothpaste, have promptly formed multifunctional enzyme-supplemented colorful toothpaste.
Below in conjunction with the specific embodiment multifunctional enzyme-supplemented colorful toothpaste of the present invention is described in further detail:
Embodiment 1: multifunctional enzyme-supplemented colorful toothpaste is made up of the mastic of three kinds of colors: blue mastic, yellow mastic, colourless mastic.Its composition and weight percent content separately is as follows:
Blue mastic (containing the enzyme mastic):
Sorbitol 68%, glycerol 5%, polyoxy second rare (10) lauryl ether sodium phosphate 0.5%, 2-undecyl-N-carboxymethyl hydroxyethyl imidazole quinoline betanin 0.5%, glucide 0.1%, sodium carboxymethyl cellulose 0.3%, alginate jelly 0.85%, Herba Menthae essence 0.8%, silica 1 5%, lysozyme 0.05%, catalase 0.05%, span 0.5%, sodium dihydrogen phosphate 0.25%, light blue 1# (1% aqueous solution) 0.05%, water 8.05%.
Yellow mastic (containing the enzyme mastic):
Sorbitol 68%, glycerol 3%, sarcosyl 2.5%, glucide 0.3%, alginate jelly 1%, Herba Menthae essence 0.8%, silica 1 5%, glucanase 0.3%, glucose oxidase 0.05%, pyridone sulfur copper 0.5%, sodium dihydrogen phosphate 0.5%, D C Yellow No. 10 (1% aqueous solution) 0.05%, water 8%.
Colourless mastic (adjusting mastic):
Sorbitol 68%, glycerol 5%, sodium lauryl sulphate 1.7%, glucide 0.1%, sodium carboxymethyl cellulose 1%, Herba Menthae essence 0.8%, silica 1 5%, magnesium chloride 0.1%, strontium chloride 0.3%, water 8%.
The preparation method of the multifunctional enzyme-supplemented colorful toothpaste of present embodiment is as described above.The canned together back of the mastic of three kinds of colors forms yellow, white, blue alternate transparent striped toothpaste.In its Smalt mastic because lysozyme, catalase can stable existences in pH value is 6～7 scopes, and the polyoxy second of adding in this component rare (10) lauryl ether sodium phosphate and 2-undecyl-two kinds of surfactants of N-carboxymethyl hydroxyethyl imidazole quinoline betanin are very little to their stability influence, and span has Stabilization to it, so these two kinds of enzyme can be at blue mastic stable existence; Because the pH value of glucanase, glucose oxidase stable existence is 3.0～7.0, and pyridone sulfur copper has Stabilization to it in the yellow mastic, thus these two kinds of enzyme can stable existence in yellow mastic; In the colourless mastic, because sodium lauryl sulphate is bigger to the influence of bioenzyme activity, therefore it being added in this component, also is in order to improve the foaminess of toothpaste simultaneously; And magnesium chloride is their activator, can improve biological enzyme activity after the mastic of three kinds of colors mixes use.Therefore this kind of toothpaste (mixture of three kinds of color mastic) combines four kinds of enzyme and strontium chloride, has played anti-inflammation and sterilization, desensitizes, whitens, removes dental plaque, multi-efficiencies such as prevention and treatment alveodental suppression.
Embodiment 2: multifunctional enzyme-supplemented colorful toothpaste is made up of the mastic of three kinds of colors: yellow mastic, white mastic, green mastic.Its composition and percentage by weight separately is as follows:
Yellow mastic (containing the enzyme mastic):
Sorbitol 30%, propylene glycol 3%, Polyethylene Glycol 6%, sarcosyl 3%, glucide 0.2%, sodium carboxymethyl cellulose 0.85%, alginate jelly 0.7%, Herba Menthae Rotundifoliae essence 0.8%, silica 1 8%, proteinase-10 .1%, bromelain 1%, peptone 0.1%, sodium dihydrogen phosphate 0.25%, titanium dioxide 0.5%, lemon yellow (1% aqueous solution) 0.5%, water 35%.
White mastic (containing the enzyme mastic):
Sorbitol 17%, glycerol 3%, sarcosyl 6%, glucide 0.2%, HANSHENGJIAO 1.7%, Herba Menthae Rotundifoliae essence 1.2%, calcium hydrogen phosphate 50%, superoxide dismutase 0.005%, lipase 0.005%, tween 2%, sodium dihydrogen phosphate 0.1%, water 18.79%.
Green mastic (adjusting mastic):
Sorbitol 17%, glycerol 3%, sodium lauryl sulphate 2.5%, glucide 0.25%, HANSHENGJIAO 1.7%, Herba Menthae Rotundifoliae essence 1.2%, calcium hydrogen phosphate 50%, taurine 0.1%, sodium dihydrogen phosphate 0.5%, sodium copper chlorophllin 0.03%, water 23.72%.
The preparation method of the multifunctional enzyme-supplemented colorful toothpaste of present embodiment is as described above.The canned together back of the mastic of three kinds of colors forms yellow, white, green alternate striped toothpaste.PH value owing to protease, bromelain stable existence in the wherein yellow mastic is 6.0～7.0, and sarcosyl is smaller to their influence, and peptone has Stabilization to it, so these two kinds of enzyme energy stable existences; Because the pH value of superoxide dismutase, lipase stable existence is 6.0～10.5, and sarcosyl does not have influence substantially to these two kinds of enzymes, and tween has Stabilization to it in the white mastic, so these two kinds of enzyme can stable existence; In the green mastic, because sodium lauryl sulphate is bigger to the influence of bioenzyme activity, therefore it being added in this component, also is in order to improve the foaminess of toothpaste simultaneously; Taurine is the activator of these enzymes, after the mastic of three kinds of colors mixes use, can improve biological enzyme activity.This kind of toothpaste (mixture of three kinds of color mastic) combines four kinds of enzyme and sodium copper chlorophllin, has therefore played residue in the decomposition oral cavity, deodorization, fresh breath, multi-efficiencies such as treatment gingivitis, periodontitis, oral ulcer.
Embodiment 3: multifunctional enzyme-supplemented colorful toothpaste is made up of the mastic of two kinds of colors: white mastic and red mastic.Its composition and weight percent content separately is as follows:
White mastic (containing the enzyme mastic):
Sorbitol 24%, diethylene glycol 10%, glycerol 5%, imidazoline is a both sexes interfacial agent 2.5%, glucide 0.1%, sodium carboxymethyl cellulose 1.05%, xanthan gum 0.3%, Mentholum 0.1%, Herba Menthae Herba Menthae Rotundifoliae essence 0.8%, silicon dioxide 25%, titanium dioxide 1%, amylase 1.5%, carase 0.5%, span 4%, sodium dihydrogen phosphate 0.5%, water 23.65%.
Red mastic (adjusting mastic):
Sorbitol 20%, glycerol 5%, Polyethylene Glycol 6%, sodium lauryl sulphate 2.5%, glucide 0.3%, sodium carboxymethyl cellulose 1.05%, carrageenan 0.6%, Mentholum 0.1%, Herba Menthae Herba Menthae Rotundifoliae essence 1.05%, silicon dioxide 20%, titanium dioxide 1%, calcium chloride 1%, sodium dihydrogen phosphate 0.14%, sodium monofluorophosphate 0.76%, potassium nitrate 5%, red 28# (1% aqueous solution) 0.5%, water 35%.
The preparation method of the multifunctional enzyme-supplemented colorful toothpaste of present embodiment is as described above.The canned together back of the mastic of two kinds of colors forms red, white alternate striped toothpaste.Because the pH value of amylase, carase stable existence is 3.0～7.0, and imidazoline is that the both sexes interfacial agent is very little to the stability influence of these two kinds of enzymes, and span has Stabilization to it in the wherein white mastic, so these two kinds of enzyme can stable existence; In the red mastic,, therefore it is added in this component because sodium lauryl sulphate is bigger to the influence of bioenzyme activity, also be in order to improve the foaminess of toothpaste simultaneously, calcium chloride is the activator of these enzymes, after the mastic of two kinds of colors mixes use, can improve the enzyme of enzyme and live.This kind of toothpaste (mixture of two kinds of color mastic) combines two kinds of enzyme and sodium monofluorophosphate, potassium nitrate, has therefore played desensitization, has decomposed multi-efficiencies such as food debris, caries prevention, tooth-whitening in the oral cavity.
Claims (2)
1. multifunctional enzyme-supplemented colorful toothpaste, it is characterized in that: this toothpaste is made up of a kind of adjusting mastic of color and the enzyme mastic that contains of multiple color, contain chemicals additive and enzyme activator in the described adjusting mastic, contain enzyme and enzyme stabilizing agent described containing in the enzyme mastic, the component of described adjusting mastic and weight percent content are:
Wetting agent 20～73%
Abrasivus 15～50%
Thickening agent 1～1.7%
Surfactant 1.7～2.5%
Essence 0.8～1.2%
Water 8～35%
Glucide 0.1～0.3%
Pigment 0～0.5%
Polyethylene Glycol 0～6%
Chemicals additive 0.03～5%
Mentholum 0～0.1%
Sodium dihydrogen phosphate 0～0.5%
Titanium dioxide 0～1%
Enzyme activator 0.1～1%
Described every kind of component and weight percent content that contains the enzyme mastic is:
Wetting agent 20～73%
Abrasivus 15～50%
Thickening agent 1～1.7%
Surfactant 1～6%
Essence 0.8～1.2%
Water 8～35%
Glucide 0.1～0.3%
Pigment 0～0.5%
Polyethylene Glycol 0～6%
Enzyme 0.01～2%
Mentholum 0～0.1%
Sodium dihydrogen phosphate 0.1～0.5%
Titanium dioxide 0～1%
Enzyme stabilizing agent 0.1～4%
Described enzyme is glucanase, lysozyme, protease, glucose oxidase, amylase, superoxide dismutase, catalase, lipase, carase or bromelain; In amylase, glucose oxidase, glucanase, the carase one or more are added in a kind of color mastic; In lysozyme, protease, catalase, the bromelain one or more are added in the mastic of another kind of color; In superoxide dismutase, the lipase one or both are added in the mastic of other color; Described chemicals additive is one or more in sodium monofluorophosphate, sodium fluoride, tertiary sodium phosphate, tetrasodium pyrophosphate, potassium pyrophosphate, potassium nitrate, carbamide, sodium phytate, strontium chloride, pure as jade pure, sodium copper chlorophllin, sodium chloride, zinc citrate, potassium citrate, the calcium glycerophosphate; Described enzyme stabilizing agent is one or more in pyridone sulfur copper and salt thereof, tween, span, peptone, the gelatin; Described enzyme activator is one or more in manganese chloride, calcium chloride, magnesium chloride, taurine, glycine, the aspartic acid; Described wetting agent is one or more in sorbitol, glycerol, propylene glycol, the diethylene glycol; Described surfactant is that sodium lauryl sulphate, sarcosyl, imidazoline are one or more in both sexes interfacial agent, polyoxyethanyl ether phosphoric acid and salt thereof, two polyoxy vinyl alkyl ether phosphoric acids and salt thereof, the polyoxyethanyl ether tripolyphosphate; Described abrasivus is one or more in calcium carbonate, silicon dioxide, aluminium hydroxide, the calcium hydrogen phosphate; Described thickening agent is one or more in sodium carboxymethyl cellulose, carrageenan, HEC, HANSHENGJIAO, alginate jelly, card ripple, the aluminium-magnesium silicate.
2. the preparation method of multifunctional enzyme-supplemented colorful toothpaste according to claim 1 is characterized in that this method comprises the steps:
1) mastic is regulated in preparation: first with the sorbitol in the wetting agent according to the percentage by weight of described adjusting mastic, chemicals additive soluble in water and raw material mix homogeneously soluble in water in water and the component, add glycerol, propylene glycol or diethylene glycol and mixtures of thickening agents in the wetting agent then, add chemicals additive not soluble in water at last, the enzyme activator, abrasivus, surfactant and other raw material stirring not soluble in water be the also degassing evenly, makes a kind of mastic of color;
2) the preparation different colours contain the enzyme mastic: the pH scope with the enzyme stable existence is divided into following three classes with described enzyme:
A. amylase, glucose oxidase, glucanase and carase,
B. lysozyme, protease, catalase and bromelain,
C. superoxide dismutase and lipase;
Contain the enzyme mastic with what above-mentioned three class enzyme were made different colours respectively, each preparation technology who contains the enzyme mastic is identical, concrete preparation technology is as follows: according to the described percentage by weight that contains the enzyme mastic earlier with the sorbitol in the wetting agent, water and raw material mix homogeneously soluble in water add glycerol, propylene glycol or diethylene glycol in the wetting agent and the mixture of thickening agent and enzyme then; Add enzyme stabilizing agent, abrasivus, surfactant and other raw material not soluble in water at last, stir and outgas, make and contain the enzyme mastic;
3) fill: the adjusting mastic that will prepare and contain the enzyme mastic and be filled to together in the Flexible tube for toothpaste, promptly make the alternate toothpaste with enzyme of multi-functional colour bar.
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| WO2014056212A1 (en) * | 2012-10-13 | 2014-04-17 | Zhang Bin | Multi-action toothpaste |
| CN104490677A (en) * | 2014-12-10 | 2015-04-08 | 唯美度科技（北京）有限公司 | Lipidosome essence emulsion and preparation method thereof |
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| CN105769600B (en) * | 2014-12-23 | 2018-11-06 | 安徽绿微康生物科技有限公司 | Dentifrice composition with potent antibacterial function |
| CN105769745B (en) * | 2014-12-23 | 2018-11-06 | 安徽绿微康生物科技有限公司 | Improve the probiotics dentifrice composition of oral health |
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| CN106924120A (en) * | 2017-04-25 | 2017-07-07 | 上海中翊日化有限公司 | A kind of oral care substance of antibacterial, fresh breath |
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| CN107737024B (en) * | 2017-09-30 | 2018-11-16 | 广州康云生物科技有限公司 | A kind of compositions of additives containing biological lysozyme |
| CN107982078A (en) * | 2017-12-05 | 2018-05-04 | 张藜泷 | A kind of multipurpose tooth paste of the mineral element containing Khotan jade |
| CN108652993A (en) * | 2018-07-18 | 2018-10-16 | 丽睿客信息科技（北京）有限公司 | A kind of oral care composition and its application |
| CN110755357A (en) * | 2019-11-18 | 2020-02-07 | 苏州克劳丽化妆品有限公司 | Oral care composition, oral care preparation and application |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1366875A (en) * | 2001-10-12 | 2002-09-04 | 天津蓝天集团股份有限公司 | Biological enzyme toothpaste |
| CN1688282A (en) * | 2002-08-28 | 2005-10-26 | 高露洁-棕榄公司 | Dual component dental composition containing enzyme |
| CN1720891A (en) * | 2005-06-06 | 2006-01-18 | 美晨集团股份有限公司 | Enzyme-containing toothpaste and its preparing process |
| CN1771902A (en) * | 2005-11-04 | 2006-05-17 | 山东师范大学 | Multifunctional health toothpaste and its production process |
-
2006
- 2006-05-26 CN CNB2006100120085A patent/CN100417373C/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1366875A (en) * | 2001-10-12 | 2002-09-04 | 天津蓝天集团股份有限公司 | Biological enzyme toothpaste |
| CN1688282A (en) * | 2002-08-28 | 2005-10-26 | 高露洁-棕榄公司 | Dual component dental composition containing enzyme |
| CN1720891A (en) * | 2005-06-06 | 2006-01-18 | 美晨集团股份有限公司 | Enzyme-containing toothpaste and its preparing process |
| CN1771902A (en) * | 2005-11-04 | 2006-05-17 | 山东师范大学 | Multifunctional health toothpaste and its production process |
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