CN101288636A - Preparation method of a Chinese herbal medicine bi-component toothpaste for preventing caries - Google Patents
Preparation method of a Chinese herbal medicine bi-component toothpaste for preventing caries Download PDFInfo
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Abstract
A preparation method of a Chinese herbal anti-caries dual-component toothpaste, the toothpaste comprises two pastes containing two components, wherein, one paste contains active ingredients of officinal magnolia bark, the other paste contains the effective ingredients of glucanase, a glucanase stabilizer and other matrix components are added in the paste containing the glucanase to ensure the activity of the glucanase and the stability of the paste; and a toothpaste foaming agent is added in the paste containing the ingredients of the officinal magnolia bark. The active ingredients of the officinal magnolia bark and the glucanase contained in the toothpaste are natural active matters, thus eliminating the shortcoming of the toothpaste with chemical drugs, leading the toothpaste to have the multiple effects of natural and multi-anti-caries and simultaneously maintaining the original foaming performance of the toothpaste.
Description
Technical field
The present invention relates to a kind of toothpaste, more particularly, relate to a kind of bi-component toothpaste of caries preventing Magnolia Officinalis glucanase
Background technology
In oral disease, dental caries is to cause the one of the main reasons of absence of tooth.Have result of study to prove: the Streptococcus mutans that causes dental caries is grown on the culture medium that contains sucrose can produce glucosan, and observes the enrichment phenomenon of Streptococcus mutans simultaneously.Glucosan is a kind of colloidal substance of viscosity, and it can make multiple pathogen assemble, and forms bacterial plaque on tooth.And the organic acid that produces sour pathogen generation can cause enamel decalcification, and then forms dental caries.
In order to prevent and treat dental caries, two kinds of methods of general employing in the prior art, a kind of is pharmaceutical preparation, brush teeth based on fluoride dental cream and to prevent and treat dental caries, the fluorine of high concentration is very big to the harm of human body, light then influence the growth of tooth and skeleton, chronic fluorosiss such as bone disease, dental fluorosis appear fluoridizing, heavy then can cause nausea, acute fluorosis such as vomiting, arrhythmia.Another kind is to use biologically active agents.In recent years, many scientists and medical personnel add in the toothpaste with multiple biologically active agents, have obtained good effect for the treatment dental caries.
Cortex Magnoliae Officinalis be China comparatively precious with Chinese crude drug, the chain timbers orchid.Studies show that: the effective ingredient that contains in the Cortex Magnoliae Officinalis bark has the obvious suppression effect to causing the suspicious pathogen Streptococcus mutans of dental caries; Glucanase can decompose the growth substrate glucosan that Streptococcus mutans etc. in the oral cavity causes the dental caries pathogen, can effectively suppress the gathering of pathogen.Along with the wind of " healthy harmonious; back to nature " in vogue on the current global consumption market is in vogue, natural environmental-protective, the little bioactive substance of side effect has met people and has pursued nature and healthy consumption concept, therefore Cortex Magnoliae Officinalis and glucanase instead of chemical auti-cariosity material are used at toothpaste, not only can avoid the side effect of chemical substance, and the cooperation of Cortex Magnoliae Officinalis and glucanase can reach the effect of comprehensive preventing decayed tooth.
Patent 01106513.3 is announced respectively with patent 01120480.X and is contained the relevant Chinese herbal toothpaste of Cortex Magnoliae Officinalis, be mainly used in the control of dental caries, but the interpolation of its Chinese herbal medicine there is no corresponding test, because of there is evident difference in the property of medicine of the Chinese herbal medicine of separate sources, only determine the property in passing that addition causes Chinese herbal medicine to add probably with in the past research or experience; Patent 98111713.9 announces that 98111713.9 have announced a kind of oral cleaning detergent component that contains glucanase, being used for the treatment of periodontal tissue such as dental caries and periodontitis damages and inflammation, but the glucanase instability, therefore inactivation is difficult to keep its activity in toothpaste easily.
Summary of the invention
The object of the invention provides a kind of Cortex Magnoliae Officinalis glucanase anticarious tooth paste, determine the Cortex Magnoliae Officinalis of interpolation and effect and its addition in toothpaste of glucanase component by test on the one hand, and, make the effect of the natural preventing decayed tooth of toothpaste in conjunction with the effect of Cortex Magnoliae Officinalis and dextranase activity composition; On the other hand in toothpaste at easy inactivation composition glucanase in the toothpaste, the stabilizing agent of screening enzyme, adjust other matrix components and its compatibility in the toothpaste, and adopt independently preparation technology of bi-component, to guarantee the stability of glucanase component activity and mastic self in toothpaste.
The present invention is that the technical scheme that adopts is:
The preparation method of the anticariogenic bi-component toothpaste of a kind of Chinese herbal medicine, this method comprises the steps:
1) mastic of first kind of component of preparation: with percentage by weight is that 20～73% wetting agent, 8～35% water, 0～0.5% pigment, 0～0.5% sodium dihydrogen phosphate, 0.1～0.3% glucide, 1～1.7% thickening agent, 0.03～0.3% glucanase, 0.1～4% enzyme stabilizing agent, 15～50% abrasivus and 0.8～1.2% essence mix, stir and outgas, make and contain the glucanase mastic;
2) mastic of second kind of component of preparation: the glucide of the wetting agent with 20～73%, 8～35% water, 0.1-0.3%, 0.1～0.5% sodium dihydrogen phosphate, 0～0.5% pigment, 1～1.7% thickening agent, 0.6～1% Cortex Magnoliae Officinalis composition, 15～50% abrasivus, 1～6% foaming agent and 0.8～1.2% essence mix, stir and outgas, make the mastic that contains the Cortex Magnoliae Officinalis composition;
3) canned: first kind of component that will prepare and the different compartments of second kind of component independence fill in Flexible tube for toothpaste promptly form anticariogenic bi-component toothpaste.
Foaming agent of the present invention adopts dodecyl musculamine acid sodium.The enzyme stabilizing agent adopts span, peptone, QAE hydrolytic collagen or F-68.Thickening agent adopts plain edition CMC, 9H type CMC, HANSHENGJIAO, xanthan gum, alginate jelly or carrageenan.
The present invention compared with prior art, prepared caries preventing Magnolia Officinalis glucanase bi-component toothpaste has the following advantages: the present invention is in conjunction with the functional trial of Cortex Magnoliae Officinalis composition and glucanase, determine the caries prevention effect of active component in the toothpaste (Cortex Magnoliae Officinalis composition and glucanase) and effective addition in toothpaste, and the compatibility of passing through toothpaste matrix component and glucanase is tested and glucanase stabilizing agent screening test definite toothpaste matrix composition that can guarantee dextranase activity and stability; Adopt the independent canned technology of bi-component can isolate contacting of glucanase and foaming agent simultaneously, can further guarantee the stability of glucanase, can compose again with the good foam performance of toothpaste.
The specific embodiment
The preparation method of the anticariogenic bi-component toothpaste of a kind of Chinese herbal medicine of the present invention, its concrete preparation process is as follows:
The first step, the mastic (containing the glucanase component) of first kind of component of preparation: at first, 20～73% wetting agents (are adopted glycerol, sorbitol, in the propylene glycol one or both), 8～35% water, 0.1～0.3% glucide, 0～0.5% sodium dihydrogen phosphate, 0～0.5% pigment (adopting light blue or lemon yellow) stirs; The mixture that adds 1～1.7% thickening agent (adopting plain edition CMC, 9H type CMC, HANSHENGJIAO, xanthan gum, alginate jelly, one or more in the carrageenan) and 0.03～3% glucanase then; Add 0.1～4% enzyme stabilizing agent (adopting span or peptone or QAE hydrolytic collagen egg or F-68) at last, 15～50% abrasivuss (employing silicon dioxide), 0.8～1.2% essence (adopting Herba Menthae Rotundifoliae essence or Herba Menthae essence), stir and outgas, make and contain the glucanase mastic;
Second step, the mastic (containing the Cortex Magnoliae Officinalis component) of first kind of component of preparation: at first, according to will (adopting sorbitol in 20～73% wetting agents, glycerol, in the propylene glycol one or more), 8～35% water, 0.1～0.3% glucide, 0.1～0.5% sodium dihydrogen phosphate, 0～0.5% pigment (adopting light blue or lemon yellow) stirs; Add 1～1.7% thickening agent then and (adopt plain edition CMC, 9H type CMC, HANSHENGJIAO, xanthan gum, alginate jelly, in the carrageenan one or more) and 0.6～1% water-fast Cortex Magnoliae Officinalis composition (adopt 95% magnolol, one or both of 95% honokiol) mixture, 15～50% abrasivuss (employing silicon dioxide), 1～6% foaming agent (employing sarcosyl), 0.8～1.2% essence (adopting Herba Menthae Rotundifoliae essence or Herba Menthae essence) stirs and outgases, and makes the mastic that contains the Cortex Magnoliae Officinalis composition;
The 3rd step, canned, with first component and the second component independence fill different compartments in Flexible tube for toothpaste that prepare, promptly form Chinese herbal medicine enzyme bi-component toothpaste.
In order to determine the caries prevention effect and the valid density thereof of active component (Cortex Magnoliae Officinalis composition and glucanase) in the toothpaste, the functional experiment that the present invention has carried out Cortex Magnoliae Officinalis composition and glucanase respectively: we with the effective ingredient 1mg/ml magnolol (95%) in the Cortex Magnoliae Officinalis and honokiol (95%) solution as sample, with the positive contrast of 1mg/ml Fluorinse, record magnolol and honokiol minimal inhibitory concentration (MIC) by 96 orifice plate doubling dilutions to Streptococcus mutans, result of the test is as follows: the MIC of magnolol is 15.6ug/ml, the MIC of honokiol is 15.6ug/ml, sodium fluoride 250ug/ml.Illustrate that magnolol and honokiol have the obvious suppression effect to Streptococcus mutans, and action effect obviously is better than sodium fluoride; In order to prove the effect of glucanase, we are sample with the pure enzymatic solution of glucanase, record a series of gradient dilution glucanase solution by the Dentocult method Streptococcus mutans is sticked inhibitory action, and result of the test is as follows: pure enzymatic solution is diluted to 10
-18After, glucanase sticks the obvious suppression effect that still has to Streptococcus mutans.According to above result of the test, we determine that magnolol and the honokiol addition in toothpaste is 0.6～1%, and the addition of glucanase in toothpaste is 0.03-0.3%.
Studies show that: glucanase has certain influence to thickening agent, meeting degraded thickening agent, thereby cause toothpaste thinning, divide water etc., thereby influence the stability of mastic, therefore we test the compatibility of glucanase and thickening agent, find the glucanase HEC that can degrade, cause the viscosity of lotion of toothpaste to reduce.And to other not influence of thickening agent (plain edition CMC, 9H type CMC, HANSHENGJIAO, xanthan gum, alginate jelly, carrageenan) in the test, so our preferred plain edition CMC, 9H type CMC, HANSHENGJIAO, xanthan gum, alginate jelly, carrageenan is as the thickening agent of toothpaste.
It is comparatively faint that the enzyme molecule is kept stable active force, its stable factor of infringement is numerous in the microenvironment, most of enzyme stable types are poor, seem very " tender and lovely ", limited its practical ranges, by containing the room temperature experiment and the accelerated test of enzyme stabilizing agent toothpaste, find sorbester p17, peptone, QAE hydrolytic collagen, F-68 all can and prolong the activity of glucanase in toothpaste in the stability that keeps glucanase well in lotion of toothpaste.Therefore we are added in the toothpaste stabilizing agent as glucanase with above-mentioned substance.
The first-selected anion surfactant of foaming agent of good foam performance generally can be provided, and this class material makes enzyme denaturation easily, inactivation, therefore we test the compatibility of glucanase and foaming agent, find that common two kinds of foaming agent sodium lauryl sulphates and 12 musculamines acid sodium all have certain influence to the activity of glucanase, but sarcosyl is littler than sodium lauryl sulphate to the influence of dextranase activity, therefore when preparation glucanase toothpaste, can preferentially select sarcosyl, and place it in and contain in the Cortex Magnoliae Officinalis component to reduce its influence to glucanase as foaming agent.
Studies show that: glucanase has certain influence to thickening agent, meeting degraded thickening agent, thereby cause toothpaste thinning, divide water etc., thereby influence the stability of mastic, therefore we test the compatibility of glucanase and thickening agent, find the glucanase HEC that can degrade, cause the viscosity of lotion of toothpaste to reduce.And to other not influence of thickening agent (plain edition CMC, 9H type CMC, HANSHENGJIAO, xanthan gum, alginate jelly, carrageenan) in the test, so our preferred plain edition CMC, 9H type CMC, HANSHENGJIAO, xanthan gum, alginate jelly, carrageenan is as the thickening agent of toothpaste.
Embodiment 1: the anticariogenic bi-component toothpaste of Chinese herbal medicine comprises two components: blue color component, and white component, its (percentage by weight) composed as follows separately:
Blue color component:
Sorbitol 68%, glycerol 5%, common CMC 0.3%, glucide 0.1%, xanthan gum 0.85%, Herba Menthae essence 0.8%, silica 1 5%, glucanase 0.3%, sodium dihydrogen phosphate 0.5% light blue 1# (1% aqueous solution) 0.5%, sorbester p17 0.1%, water 8.55%;
White component:
Sorbitol 63%, glycerol 5%, common CMC 0.3%, xanthan gum 0.85%, glucide 0.1%, sarcosyl 5%, sodium dihydrogen phosphate 0.5%, Herba Menthae essence 0.8%, silica 1 5%, magnolol 0.3%, honokiol 0.3%, water 8.85%.
With first component and the second component independence fill different compartments in Flexible tube for toothpaste for preparing, promptly form Chinese herbal medicine enzyme bi-component toothpaste.
Embodiment 2: the anticariogenic bi-component toothpaste of Chinese herbal medicine comprises two components: yellow color component, and white component, its (percentage by weight) composed as follows separately:
Yellow color component:
Sorbitol 65%, glucide 0.1%, carrageenan 0.7%, 9H type CMC 1%, Herba Menthae Rotundifoliae essence 1.2%, silica 1 8%, glucanase 0.03%, QAE hydrolytic collagen 0.05%, peptone 0.05%, F-68 0.05%, sodium dihydrogen phosphate 0.25%, lemon yellow (1% aqueous solution) 0.05%, water 13.52% is made mastic;
White component:
Sorbitol 65%, sarcosyl 6%, glucide 0.1%, 9H type CMC 1%, carrageenan 0.7%, dalcium biphosphate 0.05%, magnolol 1%, Herba Menthae Rotundifoliae essence 1.2%, silica 1 5%, water 9.95% is made mastic;
Yellow and white mastic independence fill different compartments in Flexible tube for toothpaste with preparing can form the alternate bi-component toothpaste of HUANGBAI(sic).
Embodiment 3: the anticariogenic bi-component toothpaste of Chinese herbal medicine comprises two components: blue color component, and yellow color component, its component separately following (percentage by weight):
Blue color component:
Propylene glycol 20%, glucide 0.3% alginate jelly 0.6%, HANSHENGJIAO 0.6% Herba Menthae Rotundifoliae essence 1.1%, glucanase 0.2% peptone 2%, span 2%; Light blue 1# (1% aqueous solution) 0.2%, silicon dioxide 50%, water 23%.
White component:
Propylene glycol 20%, dodecyl musculamine acid sodium 1%, glucide 0.3%, alginate jelly 0.6%, HANSHENGJIAO 0.6%, Herba Menthae Rotundifoliae essence 1.1%, sodium dihydrogen phosphate 0.5%, honokiol 0.7% silicon dioxide 50%, lemon yellow (1% aqueous solution) 0.2%, water 25%.
With first component and the second component independence fill different compartments in Flexible tube for toothpaste for preparing, can form blue yellow alternate bi-component toothpaste.
Claims (4)
1. the preparation method of the anticariogenic bi-component toothpaste of Chinese herbal medicine, this method comprises the steps:
1) first kind of component mastic of preparation: with percentage by weight is that 20～73% wetting agent, 8～35% water, 0～0.5% pigment, 0～0.5% sodium dihydrogen phosphate, 0.1～0.3% glucide, 1～1.7% thickening agent, 0.03～0.3% glucanase, 0.1～4% enzyme stabilizing agent, 15～50% abrasivus and 0.8～1.2% essence mix, stir and outgas, make and contain the glucanase mastic;
2) second kind of component mastic of preparation: the glucide of the wetting agent with 20～73%, 8～35% water, 0.1-0.3%, 0.1～0.5% sodium dihydrogen phosphate, 0～0.5% pigment, 1～1.7% thickening agent, 0.6～1% Cortex Magnoliae Officinalis composition, 15～50% abrasivus, 1～6% foaming agent and 0.8～1.2% essence mix, stir and outgas, make and contain the Cortex Magnoliae Officinalis mastic;
3) canned: first kind of component mastic that will prepare and the different compartments of second kind of component mastic independence fill in Flexible tube for toothpaste promptly form anticariogenic bi-component toothpaste.
2. according to the preparation method of the anticariogenic bi-component toothpaste of the described a kind of Chinese herbal medicine of claim 1, it is characterized in that: foaming agent adopts dodecyl musculamine acid sodium.
3. according to the preparation method of the anticariogenic bi-component toothpaste of the described a kind of Chinese herbal medicine of claim 1, it is characterized in that: the enzyme stabilizing agent adopts span, peptone, QAE hydrolytic collagen or F-68.
4. according to the preparation method of the anticariogenic bi-component toothpaste of the described a kind of Chinese herbal medicine of claim 1, it is characterized in that: thickening agent adopts plain edition CMC, 9H type CMC, HANSHENGJIAO, xanthan gum, alginate jelly or carrageenan.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018148813A1 (en) * | 2017-02-17 | 2018-08-23 | Mineração Curimbaba Ltda. | Use of a thermophosphate fertilizer that has low solubility in water and method for reducing eutrophication of water bodies due to fertilizers |
| CN114588059A (en) * | 2022-03-25 | 2022-06-07 | 湖南有美生物科技有限公司 | Preparation method and application of oral cavity mothproof paste |
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2008
- 2008-06-13 CN CN2008101148725A patent/CN101288636B/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018148813A1 (en) * | 2017-02-17 | 2018-08-23 | Mineração Curimbaba Ltda. | Use of a thermophosphate fertilizer that has low solubility in water and method for reducing eutrophication of water bodies due to fertilizers |
| CN114588059A (en) * | 2022-03-25 | 2022-06-07 | 湖南有美生物科技有限公司 | Preparation method and application of oral cavity mothproof paste |
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| CN101288636B (en) | 2010-09-01 |
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Effective date of registration: 20190104 Address after: 100084 Beijing 100084 box 82 box, Tsinghua University Patent Office Co-patentee after: Suzhou Crowley Cosmetics Co., Ltd. Patentee after: Tsinghua University Address before: 100084 Beijing 100084 box 82 box, Tsinghua University Patent Office Co-patentee before: Jiangsu Longliqi Biotechnology Co., Ltd. Patentee before: Tsinghua University |
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Effective date of registration: 20210526 Address after: 215500 Xinzhuang section of 227 provincial road, Changshu City, Suzhou City, Jiangsu Province Patentee after: Crowley Cosmetics Co.,Ltd. Address before: 100084 Beijing 100084 mailbox 82 box Tsinghua University Patent Office Patentee before: TSINGHUA University Patentee before: Suzhou Crowley Cosmetics Co.,Ltd. |
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Effective date of registration: 20210610 Address after: 100089 Qinghua garden, Haidian District, Beijing Patentee after: TSINGHUA University Patentee after: Crowley Cosmetics Co.,Ltd. Address before: 215500 Xinzhuang section of 227 provincial road, Changshu City, Suzhou City, Jiangsu Province Patentee before: Crowley Cosmetics Co.,Ltd. |