CN104490677A - Lipidosome essence emulsion and preparation method thereof - Google Patents
Lipidosome essence emulsion and preparation method thereof Download PDFInfo
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- CN104490677A CN104490677A CN201410751570.4A CN201410751570A CN104490677A CN 104490677 A CN104490677 A CN 104490677A CN 201410751570 A CN201410751570 A CN 201410751570A CN 104490677 A CN104490677 A CN 104490677A
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Abstract
The invention provides a lipidosome essence emulsion and a preparation method thereof. The lipidosome essence emulsion consists of the following components in percentage by weight: 0.5-2% of a bioactive component composition, 0.3-2% of a saussurea involucrate extract, 0.7-3.5% of hyaluronic acid, 2-10% of glycerol, 3-6% of propylene glycol, 0.04-0.5% of Tween-80, 0.034-0.35% of Tween-20, 0.3-1% of span-80, 0.07-0.55% of poloxamer 188, 0.4-2% of lecithin, 0.02-0.2% of a bioactive component stabilizer and the balance being de-ionized water. The lipidosome essence emulsion has functions of whitening, moisturizing, resisting aging and the like; by virtue of the bioactive component stabilizer, the bioactive component can be stably kept in the substrate of the essence emulsion; and by virtue of the lipidosome preparation of the essence emulsion, the percutaneous permeability of active ingredients is improved and the bioavailability of skin is enhanced.
Description
Technical field
The present invention relates to a kind of cosmetics, particularly relate to a kind of liposome essence lotion and preparation method thereof.
Background technology
Essence series products is the superfine product in skin care item, compared with other ordinary cosmetics, its composition is exquisite, effect is powerful, Be very effective, remains the noble quality that it has and mystery.Essence series products contains the nutritional labelings such as trace element, collagen protein, serum, and its effect has anti-aging, crease-resistant, moisturizing, whitening, removes speckle etc.Essence divides water preparation, oil preparation two kinds, and that extracts is high nutrient and is concentrated, and the nutritional labeling contained by it is the highest in all cosmetics.
Now on the market containing the essence of bioactive ingredients, that the mixing of all raw materials is integrally prepared from mostly, and active component is generally stablized poor, the specific steady-state conditions of demand fulfillment, therefore be difficult to ensure bioactive ingredients stable existence in essence, and often cause the bioavailability of active component low, can not be absorbed better by skin.
Summary of the invention
Main purpose of the present invention is to provide a kind of liposome essence lotion and preparation method thereof.
Liposome essence lotion of the present invention, comprises the component 0.5-2% active component composition of following weight percentage, 0.3-2% Herba Saussureae Involueratae extract, 0.7-3.5% hyaluronic acid, 2-10% glycerol, 3-6% propylene glycol, 0.04-0.5% tween 80,0.034-0.35% tween 20,0.3-1% Arlacel-80,0.07-0.55% PLURONICS F87,0.4-2% lecithin, 0.02-0.2% bioactive ingredients stabilizing agent, deionized water surplus;
Described active component composition is cell growth factor, fibroin, sheep placental extract, any three kinds or more combination in superoxide dismutase;
Described bioactive ingredients stabilizing agent is peptone, potassium dihydrogen phosphate, any two kinds or two or more combination in gelatin.
Preferably, liposome essence lotion of the present invention comprises the component of following weight percentage: 0.8-1.5% active component composition, 0.5-1.5% Herba Saussureae Involueratae extract, 1-3% hyaluronic acid, 4-8% glycerol, 4-6% propylene glycol, 0.1-0.4% tween 80,0.09-0.3% tween 20,0.5-0.8% Arlacel-80,0.1-0.5% PLURONICS F87,0.6-1.8% lecithin, 0.08-0.16% bioactive ingredients stabilizing agent, deionized water surplus;
Described active component composition is made up of the raw material of following three kinds or more weight: growth factor-21-3 parts, fibroin 1-2 part, sheep placental extract 1-3 part, superoxide dismutase 1-3 part;
Described bioactive ingredients stabilizing agent is made up of the raw material of two or more weight following: peptone 1-2 part, potassium dihydrogen phosphate 1-2 part, gelatin 1-3 part.
More preferably, liposome essence lotion of the present invention comprises the component of following weight percentage: 1.2% active component composition, 1% Herba Saussureae Involueratae extract, 2% hyaluronic acid, 6% glycerol, 5% propylene glycol, 0.2% tween 80,0.2% tween 20,0.6% Arlacel-80,0.3% PLURONICS F87,1.2% lecithin, 0.12% bioactive ingredients stabilizing agent, deionized water surplus;
Parts by weight during each component proportion of described active component composition are: growth factor-21 part, fibroin 1 part, sheep placental extract 1 part, superoxide dismutase 1 part;
Parts by weight during each component proportion of described bioactive ingredients stabilizing agent are: peptone 1 part, potassium dihydrogen phosphate 1 part, 2 parts, gelatin.
The invention provides the method preparing above-mentioned liposome essence lotion, comprise the following steps:
(1) 0.5-2% active component composition is mixed with 0.02-0.2% bioactive ingredients stabilizing agent and 2-10% glycerol, add deionized water according to the weight ratio 1:1-2 of mixture and deionized water, stir;
(2) in the mixed solution of step (1), add 0.3-2% Herba Saussureae Involueratae extract and 0.7-3.5% hyaluronic acid, stir;
(3) by 3-6% propylene glycol, 0.04-0.5% tween 80,0.034-0.35% tween 20,0.3-1% Arlacel-80,0.07-0.55% PLURONICS F87,0.4-2% lecithin mixes, after fully dissolving at 42-48 DEG C, mix with the mixed solution of step (2), supply remaining deionized water, pour 100-120mpa in high pressure homogenizer into, carry out high-pressure homogenisation, thing to be mixed, to transparent or semitransparent rear taking-up, cools and obtains liposome essence lotion.
Wherein, the weight ratio of step (1) mixture and deionized water is preferably 1:2.
Wherein, the propylene glycol of step (3), tween 80, tween 20, Arlacel-80, PLURONICS F87, lecithin mixing are preferably fully dissolved at 45 DEG C.
Step (3) high pressure homogenizer pressure is preferably 100mpa.
Liposome essence lotion provided by the invention contains active component composition and comprises cell growth factor, fibroin, sheep placental extract and superoxide dismutase.Cell growth factor is the cytokine with stimulating cellular growth activity, powerful, has deep layer repair, plays immeasurable great function in current clinical medicine and surgical operation and cosmetic surgery.Fibroin, be the natural polymer fibrin extracted from silkworm silk, content accounts for 70% ~ 80% of silkworm silk, containing 18 seed amino acids, wherein glycine (gly), alanine (ala) and serine (ser) account for more than 80% of total composition, there is remarkable beauty functions: potent lasting moisture-retaining capacity, naturally crease-resistant, promote the secretion of collagen protein, potently to brighten, uv-resistant effect, anti-inflammatory, the ability of pock and improve inflammatory wound effect.Sheep placental extract refers to a kind of active factors extracted from the lamb embryo growing about 5 months in the black sheep parent of the Alps high mountain of height above sea level more than 2300 meters containing the cell generation enriching active substance especially, skin quality can be improved, fine and smooth skin, reduces skin pore, makes skin careful flawless.Superoxide dismutase can impel peroxide radical to change into hydrogen peroxide and oxygen, thus the peroxide radical supervened in eliminate the inflammation process, thus generation has powerful antiinflammatory action and antidotal effect.
A kind of liposome essence lotion prepared by the present invention contains Herba Saussureae Involueratae extract, and Herba Saussureae Involueratae is Compositae herbaceos perennial.High 15-35 centimetre, the exotic flowers and rare herbs that it is still not rare to see, except having ornamental value, are also rare Tibetan medicines, can accelerate the metabolism of skin, reduce wrinkle, make skin keep gloss, plentiful.Slow down aging.And there is good curative effect to facial freckle, chloasma hepaticum etc.
A kind of liposome essence lotion prepared by the present invention contains hyaluronic acid.The straight chain polymer polysaccharide that hyaluronic acid is made up of dissacharide units (glucuronic acid-N-second sulfur aminoglucose) is the material naturally existed in a kind of tissue.In the skin corium of human skin, play the key player of substrate, be that the transport between maintenance overall in organizational structure or cell all has very important function, having moisture-keeping function, is the secret keeping young full skin.
Compared with prior art, prepared a kind of liposome essence lotion has whitening, moisturizing, anti-ageing multiple efficacies of waiting for a long time in the present invention; Bioactive ingredients stabilizing agent wherein can make bioactive ingredients can keep stable existence in the substrate of essence lotion; The preparation of essence lotion liposomal can improve the percutaneous permeability of effective ingredient, strengthens cutaneous bioavailability, is absorbed by the skin utilization better.
Detailed description of the invention
Following examples further illustrate content of the present invention, but should not be construed as limitation of the present invention.Without departing from the spirit and substance of the case in the present invention, the amendment do the inventive method, step or condition or replacement, all belong to scope of the present invention.
If do not specialize, the conventional means that technological means used in embodiment is well known to those skilled in the art, the present invention's raw material used is commercially available prod.
Embodiment 1
In the present embodiment liposome essence lotion composition and content as follows: 1.2g active component composition, 1g Herba Saussureae Involueratae extract, 2g hyaluronic acid, 6g glycerol, 5g propylene glycol, 0.2g tween 80,0.2g tween 20,0.6g Arlacel-80,0.3g PLURONICS F87,1.2g lecithin, 0.12g bioactive ingredients stabilizing agent, deionized water complements to total system 100g;
Parts by weight during each component proportion of described active component composition are: cell growth factor 0.3g, fibroin 0.3g, sheep placental extract 0.3g, superoxide dismutase 0.3g;
Parts by weight during each component proportion of described bioactive ingredients stabilizing agent are: peptone 0.04g, potassium dihydrogen phosphate 0.04g, gelatin 0.08g.
Prepare the method for liposome essence lotion, comprise the following steps:
(1) 1.2g active component composition is mixed with 0.12g bioactive ingredients stabilizing agent and 6g glycerol, add deionized water according to the weight ratio 1:2 of mixture and deionized water, stir;
(2) in the mixed solution of step (1), add 1g Herba Saussureae Involueratae extract and 2g hyaluronic acid, stir;
(3) by 5g propylene glycol, 0.2g tween 80,0.2g tween 20,0.6g Arlacel-80,0.3g PLURONICS F87,1.2g lecithin mixes, after fully dissolving at 45 DEG C, mix with the mixed solution of step (2), supply remaining deionized water to 100g, pour 100mpa in high pressure homogenizer into, carry out high-pressure homogenisation, thing to be mixed, to transparent or semitransparent rear taking-up, cools and obtains liposome essence lotion.
Embodiment 2
In the present embodiment liposome essence lotion composition and content as follows: 1.5g active component composition, 1.5g Herba Saussureae Involueratae extract, 1g hyaluronic acid, 8g glycerol, 4g propylene glycol, 0.4g tween 80,0.09g tween 20,0.8g Arlacel-80,0.1g PLURONICS F87,1.8g lecithin, 0.16g bioactive ingredients stabilizing agent, deionized water complements to total system 100g;
Parts by weight during each component proportion of described active component composition are: cell growth factor 0.6g, fibroin 0.6g, sheep placental extract 0.3g;
Parts by weight during each component proportion of described bioactive ingredients stabilizing agent are: peptone 0.08g, potassium dihydrogen phosphate 0.08g.
Preparation method is with embodiment 1, and only raw material weight is different from embodiment 1, is limited to the weight of the present embodiment.
Embodiment 3
In the present embodiment liposome essence lotion composition and content as follows: 0.8g active component composition, 1.5g Herba Saussureae Involueratae extract, 1g hyaluronic acid, 8g glycerol, 4g propylene glycol, 0.4g tween 80,0.09g tween 20,0.8g Arlacel-80,0.1g PLURONICS F87,1.8g lecithin, 0.08g bioactive ingredients stabilizing agent, deionized water complements to total system 100g;
Parts by weight during each component proportion of described active component composition are fibroin 0.2g, sheep placental extract 0.2g, superoxide dismutase 0.4g;
Parts by weight during each component proportion of described bioactive ingredients stabilizing agent are: potassium dihydrogen phosphate 0.04g, gelatin 0.04g.
Preparation method is with embodiment 1, and only raw material weight is different from embodiment 1, is limited to the weight of the present embodiment.
Embodiment 4 ductility test
The liposome essence lotion that test sample: embodiment 1-3 prepares, commercially available essence lotion.
Method of testing: spread upon respectively on plastic plate by sample, smear their ductility of test with finger, emulsion extends apart from longer, proves that its quality is salubriouser, easily absorbs.
Test result shows, and the liposome essence lotion distance that embodiment of the present invention 1-3 obtains is longer, especially best with the liposome essence lotion ductility effect that embodiment 1 is obtained, illustrates that its quality is salubriouser, easily absorbs.
Embodiment 5 liposome essence lotion antioxidation is tested
The liposome essence lotion that test sample: embodiment 1-3 is obtained, deionized water (contrast 1), commercially available essence (contrast 2).
Test cell: people source fibroblast (Skin Cell)
Method of testing: fibroblast inoculation, with on 96 porocyte culture plates, is placed in CO2 gas incubator and cultivates, cell attachment after 3 days.Irradiate 30min under adherent fibroblasts being placed in ultraviolet light, carry out photooxidation process.After getting the above-mentioned each sample deionized water dissolving of 1mg, with sample injector, sample liquid is added in the aperture of fibroblastic Tissue Culture Plate of photooxidation process, be placed in incubator to cultivate, after 3 days, counting cells number judgement sample is to the repairing effect of fibroblast oxidative damage.
Table 1
| Sample | Embodiment 1 | Embodiment 2 | Embodiment 3 | Contrast 1 | Contrast 2 |
| Cell quantity | 4.0×10 5 | 3.6×10 5 | 3.8×10 5 | 4×10 0 | 6×10 3 |
Test result shows; The liposome essence lotion that embodiment 1-3 obtains has protective effect to the cell after photooxidation process, illustrates that the liposome essence lotion that embodiment of the present invention 1-3 obtains has anti-oxidation function, and wherein the liposome essence lotion anti-oxidation function of embodiment 1 is best.
The whitening of embodiment 6 liposome essence lotion is tested
The liposome essence lotion that test sample: embodiment 1-3 is obtained, deionized water (contrast 1), commercially available essence (contrast 2).
Test cell: people source melanocyte
Method of testing: after getting 1mg each sample deionized water dissolving, with sample injector, sample liquid being added growth has in the aperture of the Tissue Culture Plate of adherent melanocyte, be placed in incubator to cultivate, after 3 days, counting cells number is to judge the inhibition of sample to melanocyte.
Table 2
| Sample | Cell quantity |
| Embodiment 1 | 5 |
| Embodiment 2 | 8 |
| Embodiment 3 | 10 |
| Contrast 1 | 2×10 5 |
| Contrast 2 | 100 |
Test result shows; The growth of liposome essence lotion to melanocyte that embodiment 1-3 obtains has obvious suppression, illustrates that invented liposomes essence lotion has white-skinned face function, especially best with the liposome essence lotion whitening effect of embodiment 1.
Although above the present invention is described in detail with a general description of the specific embodiments, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (7)
1. a liposome essence lotion, comprises the component of following weight percentage: 0.5-2% active component composition, 0.3-2% Herba Saussureae Involueratae extract, 0.7-3.5% hyaluronic acid, 2-10% glycerol, 3-6% propylene glycol, 0.04-0.5% tween 80,0.034-0.35% tween 20,0.3-1% Arlacel-80,0.07-0.55% PLURONICS F87,0.4-2% lecithin, 0.02-0.2% bioactive ingredients stabilizing agent, deionized water surplus;
Described active component composition is cell growth factor, fibroin, sheep placental extract, any three kinds or more combination in superoxide dismutase;
Described bioactive ingredients stabilizing agent is peptone, potassium dihydrogen phosphate, any two kinds or two or more combination in gelatin.
2. liposome essence lotion according to claim 1, is characterized in that, comprises the component of following weight percentage: 0.8-1.5% active component composition, 0.5-1.5% Herba Saussureae Involueratae extract, 1-3% hyaluronic acid, 4-8% glycerol, 4-6% propylene glycol, 0.1-0.4% tween 80,0.09-0.3% tween 20,0.5-0.8% Arlacel-80,0.1-0.5% PLURONICS F87,0.6-1.8% lecithin, 0.08-0.16% bioactive ingredients stabilizing agent, deionized water surplus;
Described active component composition is made up of the raw material of following three kinds or more weight: growth factor-21-3 parts, fibroin 1-2 part, sheep placental extract 1-3 part, superoxide dismutase 1-3 part;
Described bioactive ingredients stabilizing agent is made up of the raw material of two or more weight following: peptone 1-2 part, potassium dihydrogen phosphate 1-2 part, gelatin 1-3 part.
3. liposome essence lotion according to claim 1, is characterized in that, comprises the component of following weight percentage: 1.2% active component composition, 1% Herba Saussureae Involueratae extract, 2% hyaluronic acid, 6% glycerol, 5% propylene glycol, 0.2% tween 80,0.2% tween 20,0.6% Arlacel-80,0.3% PLURONICS F87,1.2% lecithin, 0.12% bioactive ingredients stabilizing agent, deionized water surplus;
Parts by weight during each component proportion of described active component composition are: growth factor-21 part, fibroin 1 part, sheep placental extract 1 part, superoxide dismutase 1 part;
Parts by weight during each component proportion of described bioactive ingredients stabilizing agent are: peptone 1 part, potassium dihydrogen phosphate 1 part, 2 parts, gelatin.
4. prepare the method for the arbitrary described liposome essence lotion of claim 1-3, comprise the following steps:
(1) active component composition is mixed with bioactive ingredients stabilizing agent and glycerol, add deionized water according to the weight ratio 1:1-2 of mixture and deionized water, stir;
(2) in the mixed solution of step (1), add Herba Saussureae Involueratae extract and hyaluronic acid, stir;
(3) by propylene glycol, tween 80, tween 20, Arlacel-80, PLURONICS F87, lecithin mixing, after fully dissolving at 42-48 DEG C, mix with the mixed solution of step (2), supply remaining deionized water, pour 100-120mpa in high pressure homogenizer into, carry out high-pressure homogenisation, thing to be mixed, to transparent or semitransparent rear taking-up, cools and obtains liposome essence lotion.
5. method according to claim 4, is characterized in that, the weight ratio of step (1) mixture and deionized water is 1:2.
6. method according to claim 4, is characterized in that, the propylene glycol of step (3), tween 80, tween 20, Arlacel-80, PLURONICS F87, lecithin mixing, fully dissolve at 45 DEG C.
7. method according to claim 4, is characterized in that, step (3) high pressure homogenizer pressure is 100mpa.
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| CN108272741A (en) * | 2018-03-30 | 2018-07-13 | 广州科盈化妆品有限公司 | A kind of anti-wrinkle essence breast and preparation method thereof |
| CN108653004A (en) * | 2018-06-26 | 2018-10-16 | 广州诺德丽诗化妆品有限公司 | A kind of composition and preparation method thereof for maintenance of releiving with multiple moisturizing |
| CN109464336A (en) * | 2018-12-19 | 2019-03-15 | 乌鲁木齐市金花紫卉商贸有限公司 | A kind of non-pigment is preserved youthful looks powder and preparation method thereof |
| CN109589278A (en) * | 2018-10-10 | 2019-04-09 | 昆明贝泰妮生物科技有限公司 | The preparation process of high stable prinsepia utilis royle oil liposome and its application in cosmetics |
| CN111511209A (en) * | 2017-09-22 | 2020-08-07 | 德科全球收后处理股份私人有限公司 | Method for treating and controlling postharvest physiological disease of fruit through edible coating |
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Application publication date: 20150408 |