CN101023916A - Cosmetic prepared from cliff-grown tea and black goat embryo element - Google Patents
Cosmetic prepared from cliff-grown tea and black goat embryo element Download PDFInfo
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Abstract
The present invention relates to a beautifying, whitening and anti-crease cosmetic prepared by using yancha (a Chinese medicinal material) extract and sheep's placental extract through a certain preparation process. Said invention can be made into various dosage forms of cream, lotion, ointment, skin-care cream, skin-moistening liquor and facial washing milk, etc.
Description
Technical field
The present invention relates to the cosmetics of a kind of rock tea extract and sheep placental extract preparation, it can remove collagen content in free radical in the skin, antioxidation, the increase skin, suppress the melanic formation in position such as epithelium, have and be suitable for the cosmetic result that the outer defying age wrinkle removing that is coated with brightens.
Background technology
Determining the principal element of the human colour of skin---melanin is that to be present in the melanocyte of stratum basale synthetic, forerunner's tyrosine generates melanin in the melanosome under the tryrosinase effect, and this melanin unusual increasing in epidermis is that chloasma takes place the patient.Melanin is most important pigment in the skin, and it determines our colour of skin.Simultaneously, melanin also is the natural defence system of human body skin, can resist the injury of ultraviolet to skin.But when melanin produces too much or skewness, but can cause pigementation, form black speck, influence appearance." sense of loving to make up and wearing beautiful clothes, at all times all together ".The method that people once remove speckle with bleaching improve skin dark and gloomy, increase the fair and clear degree of the colour of skin, mainly be to float on the face black speck with powerful ingredient, as compositions such as retinoic acid, hydroquinone stronger bleaching effect is arranged all.Yet; use bleach can destroy the sebum film of skin surface; if during this period; skin is subjected to the stimulation of factors such as ultraviolet radiation, endocrine disturbance again; then the function of its self-protection is understood doubling effect; make melanocyte discharge more melanin, thereby cause more serious pigementation phenomenon.Along with the progress of modern science and technology, people bring into use milder, effectively Skin whitening care cosmetics reaches and causes the wish that skin and muscles are fair.By the activity of restraint of tyrosinase, reduce melanic generation, thereby prevent new pigementation, it is dark and gloomy to improve the skin that causes because of Exposure to Sunlight or endocrine disturbance, increases bright and clean degree of the colour of skin and well-balanced degree, and desalinates black speck gradually.
Can be divided into two classes from the mechanism of action of known Melanin inhibitor:, suppress melanic generation 1, to the cytotoxicity of melanocyte; 2, hinder melanic generation in the melanocyte.
(application number: the 6-O-caffeoyl Arbutin that 200610091092.4) contains can suppress, stop tyrosinase activity rock tea extract, hinders melanic formation.From the effect of research 6-O-caffeoyl Arbutin as can be seen, 6-O-caffeoyl Arbutin is not influencing the effect that under the value-added concentration of cell the B-16 melanotic tumor is shown the generation of inhibition melanin, and, if 6-O-caffeoyl Arbutin is taken out from culture medium, the melanin amount just returns to original level after 3 days, and the inhibitory action of hence one can see that 6-O-caffeoyl Arbutin is reversible.
Simultaneously, research shows that also 6-O-caffeoyl Arbutin has the various nutritional labelings of supplying the epiderm skin cell, freckle is dispeled rate reach 90%, and safety non-toxic, freckle effect is good.The reason that various speckles such as freckle, chloasma produce is to have a kind of special cell---melanocyte in people's the basal layer of epidermis; can produce melanin; just often melanin can absorb excessive daylight light; ultraviolet and protect skin particularly; if the metabolism that the melanin that generates can not the time spent and assemble deposition and speckle will occur; test with suitable B-16 melanotic tumor cultured cell, do not finding under the toxic concentration that 6-O-caffeoyl Arbutin can suppress melanic generation.After people fully study the safety of 6-O-caffeoyl Arbutin, confirm that its speckle to the generation of human body has certain curative effect.
Skin aging is relevant with several factors: 1, ultraviolet (UVA) is the arch-criminal who causes skin aging, it is not threatening our skin all the time, what need especially that people mention attention is, the radiation of UVA be have cumulative, if the protection the childhood period of the emphasis, the catabiosis of skin will come out too much in the time of 40 years old; 2, skin aging is relevant with xerosis cutis, the dry disorder that has aggravated skin metabolism again.Moistening the type cosmetics is keratinization metabolic processes of improving skin by adding high-quality wetting agent, makes it recover normal; 3, antioxidative functional weakens in the aging and body of skin, free radical increases relevantly, and many product utilization SOD (enzyme type antioxidant) were arranged in the past, reaches antioxidation, the effect of removing free radical.But since SOD to have a molecular weight big, should not be not expected by shortcomings such as skin absorbs and unstability; 4, elastin laminin degraded and degraded back modification can cause The symptoms of aging such as skin occurs following the string, relaxes, wrinkle, have just become defying age Study on Technology problem so make the degradation speed of elastin laminin slow down; 5, the aging of skin is relevant with gene, discovers that the cell-stimulating factor (ETAF) minimizing that skin aging and skin produce has the most directly relation.
Sheep placental extract: be from fresh three months pregnancy period embryo Placenta Hominiss and sheep embryo, the multiple bioactive substance that extracts through advanced person's bioengineering technology.1, this bioactive ingredients can promote growth, division, the quickening metabolism of various kinds of cell such as epidermal tissue's epithelial cell, horn cell, fibroblast, promote the absorption of cell to nutrition, strengthen the synthetic and secretion colloid material of cell, as hyaluronic acid and glycoprotein, can give senile cell with new vitality, play the effect of wrinkle preventing and removing, reduction skin melanin and coloured corpuscle content, strengthen skin elasticity, the Glycerin of whitening.2, the young factor of distinctive guarantor is to the real effective effective component of skin in the sheep placental extract, protecting the young factor is small-molecular weight (6000 dalton) organism, molecular structure is for very easily being absorbed by skin histology, enter dermal tissue: can promote the epidermis cell differentiation to upgrade, make the skin exquisiteness, tender and lovely, glossy, skin microcirculation be can improve, skin moisture and elasticity kept; Effectively replenish the anti-ageing factor of metabolism, the wrinkle of releiving, slow down aging; Regulate human endocrine, make various mottle desalinations, go down.3, sheep placental extract can make the skin delicacy: why the people bore a pretty, delicate skin in the childhood, be to be much higher than the adult because of child's epidermis cell differentiation renewal rate, and the activation factor in the sheep placental extract enters dermal tissue by blood capillary, dermal tissue cell regeneration speed is improved greatly, newborn skin cell metabolism is vigorous, and the epidermis aged cells is peeled off quickening.The raising of this epidermis cell histo-differentiation renewal rate can make skin histology keep fresh delicacy, and is smooth and moist, fully demonstrates the moving texture of skin; 4, sheep placental extract can keep moisture of skin and elasticity: people's xerosis cutis lacks flexibility because microcirculation does not freely cause, active factors in the sheep placental extract enters dermal tissue can improve skin microcirculation greatly, promote the growth of skin fiber cell and the generation of collagen protein tissue, with advancing microcirculqtory system in shape, can make skin pore shrink effectively, drain normal, and keep the eupnea of skin, prevent moisture loss, thereby keep the water balance of skin and the elasticity of skin histology; 5, sheep placental extract has crease-resistant effect: sheep placental extract is the strongest active factors of skin physiological metabolism anti-aging function, use sheep placental extract can effectively replenish the anti-ageing factor of metabolism, make the physiological metabolism of skin histology obtain adjusting and strengthening, dermal tissue is full, the enhancing surface tension thereby make, slow down and eliminate the wrinkle that forms because of epidermal tissue is loose, allow skin seem younger.
Though sheep placental extract has been used in the cosmetics, but do not report the cosmetics that contain rock tea extract and sheep placental extract simultaneously as yet, surprisingly, resultant effect after rock tea extract and the sheep placental extract combination, the effect that it is whitened, wrinkle resistance uses separately much larger than these two kinds of materials, in other words, coupling has excited the curative effect of these materials, obtains synergism on the effect of whitening anti-wrinkling.Therefore, the type of service of rock tea extract, sheep placental extract is worth further exploitation in the cosmetics.
Summary of the invention
The object of the present invention is to provide the cosmetics of a kind of Pear Power, anti-wrinkle effect.
According to the present invention, this is whitened, anti-wrinkle cosmetic is made up of a kind of profit silicone oil system, and comprises following active component (content is to represent with respect to the percentage by weight of cosmetics gross weight):
0.1-3% rock tea extract
0.1-1% sheep placental extract
In addition, the mixture of cosmetic additive, carrier or these materials commonly used has been formed remainder, makes total amount reach 100%.
Find the above-mentioned compositions that contains composition to human body skin Pear Power, anti-wrinkle effect, and can significantly improve the microgroove of old skin.
Rock tea extract of the present invention, its active component are the 6-oxy-caffeoyl-arbutins that extracts from rock tea, are a kind of effective anti-oxidants, whiten, speckle dispelling, crease-resistant etc. special effect are arranged for skin, are highly suitable for cosmetics.
Sheep placental extract of the present invention, the technology manufacturing by the industry is known is exemplified below:
(1) sheep placental extract extracting solution: Foetus Caprae seu Ovis is cleaned, be broken into the meat slurry, put into container, add an amount of enzyme, protease under 10-15 ℃ temperature, carried out enzymolysis 7-10 days as is known, obtained the sheep placental extract extracting solution, left standstill, and is standby;
(2) sheep placental extract: under aseptic condition, be raw material,, obtain the tissue fluid that granularity is 2-50 μ through cleaning, rubbing, freeze thawing and homogenate with the sheep embryo at 2-3 monthly age; Tissue fluid is carried out purification in 65-70 ℃ of following pasteurization, mistake molecular sieve and ultrafiltration, collect molecular weight less than 30000 daltonian components; The component of collecting is carried out the microporous filter degerming, and the filter membrane aperture is 0.20-0.45 μ; Obtain sheep placental extract after the lyophilization, be white particles, little sweet, free from extraneous odour, soluble in water.
The matrix of cosmetics of the present invention is oil hydrosol or cream frost, it is spread on skin and gently puts on the skin, bring special soft feel, without any gluing sense, reached and shown and himself can reduce the effect level and smooth with wrinkle, and make skin look to whiten, youth.In addition, after also finding to use for 4 weeks, the elasticity of skin can increase to 40%.An experiment in lasting 8 hours and lasting studying for a long period of time of 4 weeks show skin has kept moistening more more, so this invention complex in general has remarkable and long lasting effect.
In a word, cosmetics of the present invention have obtained a kind of level and smooth effect of skin that makes, and this effect can't obtain from its independent component.
Cosmetics of the present invention also contain cosmetic additive and carrier commonly used in preparation, as water, antiseptic, coloring agent, thickening agent, spice, alcohols, polyol, esters, electrolyte, gel forming agent, polarity and nonpolar oils, polymer, copolymer, emulsifying agent, waxiness and stabilizing agent.
Antioxidant and free radical scavenger are added in special recommendation.These materials comprise various vitamin: vitamin C and its derivant, put hydrochlorate as ascorbic acid acetate, ascorbic acid phosphate, ascorbic acid one 6 one palm fibres; Vitamin A and its derivant; Folic acid and derivant thereof: vitamin E and derivant thereof, as tocopherol acetate; Flavone or flavonoid; Amino acids is as histidine, glycine, tyrosine, tryptophan and their derivant; Carotene and carotenoid are as α one carotene, β one carotene; Uric acid and derivant thereof; The α monohydroxylated acid is as citric acid, lactic acid, malic acid; And the mixture of above-mentioned these materials.
The ratio of silicone oil is preferably at the 1-20% of cosmetics gross weight.
Cosmetics of the present invention can contain emulsifying agent with the preparation oil hydrosol.The emulsifying agent such as the 2-30 moles of ethylene oxide that are fit to oil hydrosol make an addition to linear C
8-C
22Aliphatic alcohol, C
12-C
22Fatty acid and C
8-C
15In the alkyl phenol; 1-30 moles of ethylene oxide C
12-C
22The addition compound product of fatty-acid monoester and dibasic acid esters is added to glycerol.
As previously mentioned, need not to add pigment in the product, yet if desired, pigment, pigment composition or the powder with pigment effect can be used as cosmetic additive and add, but this does not recommend.These pigment comprise that also those have pearl effect.These pigment or powder can be silicon dioxide, ferrum oxide, aluminosilicate such as Haematitum, titanium dioxide, Muscovitum, Kaolin, contain that the clay of magnetisable material such as umber and bole, calcium carbonate, Talcum, Muscovitum titanium monoxide, Muscovitum titanium monoxide iron monoxide, hydroxide are secret, nylon spherolite, ceramic spherolite, dilatancy or synthetic polymer powder, opaque natural organic matter such as the ground algae of non-expansibility, ground plant and Muscovitum titanium monoxide one toner.
Cosmetics of the present invention also can contain polyol, as propylene glycol, dipropylene glycol, ethylene glycol, isoamyl glycol, glycerol, butanediol, sorbitol and these mixture.Polyol accounts for 0.1-40% weight, preferably accounts for main assembly about 5% to about 20% weight.
Components of cosmetics of the present invention can be used as product after preparation sunscreen cream, sunlight lotion, the solarization, day cream, late frost, facial film, skin cream, cleansing milk, skin smoothing powder, eye and makes up, sends out film, hair conditioner, shampoo, bath gel, bath oil, bath quintessence oil, and in the color make-up product, as deodorant stick, spice rod, lip pomade, gel, eye shadow, muffin, Apis cerana Fabricius, kermes, foundation cream etc., the technology manufacturing that above-mentioned product is known by the industry.
Special recommendation is applicable to preparation Emulsion, facial cream, facial film, skin cream, unguentum, skin whitening liquid, transparent maintenance liquid, the cleansing milk of preserving moisture, and considers that in most of the cases these are the most common application product.
The specific embodiment
The present invention will be described in further detail by embodiment.All compositions are all represented with percent by weight except that specializing.
Embodiment 1 is suitable for the Emulsion of neutral skin
| The A phase | The C phase | ||
| Water | Add to 100 | Vitamin mixtures (B 2、B 6、B 12、C、E、D) | 1.0 |
| Glycerol | 3.0 | Ethanol | 5.0 |
| Propylene glycol | 3.0 | Rock tea extract | 3.0 |
| Sheep placental extract | 1.0 | ||
| The B phase | TiO 2 | 0.5 | |
| Silicone oil | 15.8 | Vitamin A palmitate | 0.05 |
| Spice | 0.5 | ||
| Antiseptic | 0.5 |
A prepares respectively mutually with B mutually, and in preparation process, two components all are heated to about 80 ℃, and biphase intermingling stirred 20 minutes simultaneously, and the mixture that obtains is cooled to 60 ℃, and about 5 minutes of even matter is cooled to 50 ℃ subsequently, stirs evenly 5 minutes again.Subsequently, this mixture is cooled to 35 ℃ and add the C phase, and C is in preparation separately in advance below 35 ℃.Stirred for several minute makes the product mix homogeneously.
Embodiment 2 skin moistening facial creams
| The A phase | The B phase | ||
| Emulsifying agent Biobase S | 2.5 | Glycerol | 2.5 |
| 165 self-emulsifiers | 1.5 | 1,3 butylene glycol | 3.0 |
| C 18Alcohol | 1.5 | Trehalose | 2.0 |
| Dimethicone (DC200) | 1.0 | HANSHENGJIAO | 0.3 |
| Dimethicone (DC345) | 2.0 | Water | To 100 |
| Jojoba oil | 1.0 | The C phase | |
| Tricaprin (GTCC) | 4.0 | Rock tea extract | 0.5 |
| Isopropyl myristate | 4.0 | The sheep placental extract extracting solution | 0.02 |
| Isononyl isononanoate (ININ) | 2.0 | Sodium sulfite | 0.2 |
| Azone | 0.3 | Antiseptic (Bronopol) | 0.1 |
| Propylparaben | 0.2 | ||
Embodiment 3 emollient cream (health)
| The A phase | The C phase | ||
| Water | Add to 100 | Vitamin mixtures (B 2、B 6、B 12、C、E、D) | 1.0 |
| Glycerol | 10.0 | Ethanol | 10.0 |
| Propylene glycol | 3.0 | Rock tea extract | 3.0 |
| Sheep placental extract | 0.1 | ||
| The B phase | Vitamin A palmitate | 0.5 | |
| Silicone oil | 17.8 | Spice | 0.5 |
| Antiseptic | 0.5 | ||
Preparation process is with reference to embodiment 1
Embodiment 4 is suitable for the Emulsion of dry skin
| The A phase | The C phase | ||
| Water | Add to 100 | Vitamin mixtures (B 2、B 6、B 12、C、E、D) | 1.0 |
| Glycerol | 5.0 | Ethanol | 8.0 |
| Propylene glycol | 2.0 | Rock tea extract | 0.1 |
| Sheep placental extract | 1.0 | ||
| The B phase | TiO 2Or SiO 2Pigment | 0.5 | |
| Silicone oil | 21.7 | Vitamin A palmitate | 0.5 |
| Spice | 0.5 | ||
| Antiseptic | 0.5 | ||
Preparation process is with reference to embodiment 1
Embodiment 5 skin whitening liquid
| The A phase | The C phase | ||
| Water | Add to 100 | Vitamin mixtures (B 2、B 6、B 12、C、E、D) | 1.0 |
| Glycerol | 10.0 | Ethanol | 10.0 |
| Propylene glycol | 3.0 | Rock tea extract | 0.1 |
| Sheep placental extract | 0.1 | ||
| The B phase | Vitamin A palmitate | 0.5 | |
| Silicone oil | 17.8 | Spice | 0.5 |
| Antiseptic | 0.5 |
Preparation process is with reference to embodiment 1
Embodiment 6 facial films
| The A phase | The B phase | ||
| Emulsifying agent Biobase S | 2.5 | Glycerol | 5.0 |
| 165 self-emulsifiers | 1.5 | 1,3 butylene glycol | 3.0 |
| C 18Alcohol | 1.5 | Trehalose | 2.0 |
| Vitamin E | 1.0 | HANSHENGJIAO | 0.5 |
| Isopropyl myristate | 4.0 | Water | To 100 |
| Isononyl isononanoate (ININ) | 2.0 | The C phase | |
| Azone | 0.3 | Rock tea extract | 0.5 |
| Propylparaben | 0.2 | The sheep placental extract extracting solution | 0.5 |
| Bentonite | 1.5 | ||
The synergistic confirmation of embodiment 7 The compounds of this invention
Extracorporeal biology test (activity of fungus tryrosinase suppresses) has proved the depigmentation activity according to chemical compound coupling of the present invention.
Compare with the matched group of same concentration in the solvent that contains use, the phosphate buffer, this is tested each following active depigmentation composition:
● rock tea extract
● sheep placental extract
Having under the situation of phosphate buffer, in the solution (different concentration) of appropriate solvent, 1ml 2.0 * 10 in the phosphate buffer
-30.1ml1.0 in M L-tyrosine, the phosphate buffer * 10
-450 μ lg/l fungus tyrosine solutions in M L one DOPA and the phosphate buffer, the absorbance (optical density OD) at measurement 475nm place is as the function of time.Detect inhibition percentage ratio subsequently by following formula:
For each of top two active component, the molar concentration during the inhibition numerical value of calculating observation to 25% subsequently.Obtain the concentration C of rock tea extract
1Concentration C with sheep placental extract
2, wherein:
C
1=3.25 * 10
-4M (solvent: ethanol)
C
2=1.33 * 10
-4M (solvent: water)
Subsequently, the concentration of the concentration of rock tea extract and sheep placental extract is with C
1: C
2Concentration is mixed.Subsequently,, calculate the inhibition percentage ratio (or theoretical IC) on this theory of mixtures, the actual inhibition percentage ratio (perhaps obtaining IC) that obtains corresponding to the inhibition percentage ratio sum of observed independent chemical compound.
The result is as follows:
C
1+ C
2Mixture:
Theoretical IC=45.8%
Obtain IC=68.0%
Consider the degree of accuracy (about 5%) of this test, clearly proved the synergism of two chemical compounds of coupling.
The embodiment 8 usefulness contrast experiment that whitens
The application of clinical experimenter's measures of effectiveness and " color difference meter ":
The volunteer is 9 middle-aged womens about 40 years old, and position on probation is a face; After clean, be applied in the test position for twice on the one.Observe with the test position be left cheekbone portion, right cheekbone portion is untreated contrast position.Experiment started from the beginning of midsummer, measured each position respective value with color difference meter before the experiment beginning, and test every month after this once.
(the variation of mean ± SD) of L-value in the embodiment 2 skin moistening facial cream uses
| Time | n | The contrast position | The test position |
| (d) | (right cheekbone portion) | (left cheekbone portion) | |
| 0 | 9 | 58.30±2.80 | 57.92±2.45 |
| 30 | 8 | 57.88±2.50 | 58.00±2.26 |
| 60 | 9 | 57.30±2.46 | 58.82±2.16 |
| 90 | 9 | *57.00±2.30 | *59.42±2.20 |
| The P value | P＝0.04 | P＝0.02 | |
Clinical experimenter's measures of effectiveness result:
The result shows, the experimenter after using in three months, its L-value (lightness has before using and significantly increases P＜0.05).As table 2, we can also observe from this chart, and the right cheekbone portion at position its L-value in whole midsummer process has obvious decline in contrast.This result shows that the skin moistening facial cream can not only increase facial lightness, and can resist the blackening effect of ultraviolet to skin.
The control experiment of embodiment 9 anti-wrinkle effect
For the proof anti-wrinkle effect, carried out following experiment.Experiment comprises that 21 masculinity and femininity ages were 42 years old to 61 years old experimenter.The micromorphology of skin of face (near the eyes, the corners of the mouth, nasal area) is gathered replica with silicone substance, and described material stays and solidifies the negative embossment that obtains is measured wrinkle by the electron-optical method the degree of depth and quantity.Gather after the micromorphology, for the first time Emulsion is spread on subjects's face immediately, repeat to apply this Emulsion every day twice subsequently, the about 2g/cm of consumption
2
1 group: 12 bit test persons use embodiment 1 Emulsion;
2 groups: 6 bit test persons use embodiment 3 Emulsions;
3 groups: 3 bit test persons use the solvent Emulsion of embodiment 1, but do not contain active component (being placebo).
When the 14th day and the 28th day, the micromorphology of collecting the same position of each subjects skin compares measurement in test back for the first time.During this period, the subjects all is not subjected to intensive especially solar radiation.The numerical value of measuring is the statistics meansigma methods that micromorphology is selected the district.
| The test number | |||
| 1 group | 2 groups | 3 groups | |
| Wrinkle depth weakens degree after 14 days | |||
| 10-30％ | 8 | 4 | 1 |
| 30-50％ | 4 | ||
| Wrinkle depth weakens degree after 28 days | |||
| 10-30％ | 2 | 1 | 1 |
| 30-50％ | 7 | 3 | |
| ＞50％ | 2 | 2 | |
1 group has 75% subjects to show the very good wrinkle depth effect of dwindling after 28 days.
Claims (4)
1, a kind ofly whiten, anti-wrinkle cosmetic, it is characterized in that: it contains 0.1-3% rock tea extract and 0.1-1% sheep placental extract to described cosmetics by weight.
2, as claimed in claim 1ly a kind ofly whiten, anti-wrinkle cosmetic, it is characterized in that: described cosmetics are that film, hair conditioner, shampoo, bath gel, bath oil, bath are made up, sent out to product after sunscreen cream, sunlight lotion, the solarization, day cream, late frost, facial film, facial cream, Emulsion, skin cream, cleansing milk, unguentum, skin whitening liquid, the transparent maintenance liquid of preserving moisture, skin smoothing powder, eye with quintessence oil or color make-up product.
3, as claimed in claim 1ly a kind ofly whiten, anti-wrinkle cosmetic, it is characterized in that: described cosmetics are Emulsion, facial cream, facial film, skin cream, unguentum, skin whitening liquid, transparent maintenance liquid or the cleansing milk of preserving moisture.
4, as claimed in claim 1ly a kind ofly whiten, anti-wrinkle cosmetic, it is characterized in that: described product is deodorant stick, spice rod, lip pomade, sees curry, eye shadow, muffin, Apis cerana Fabricius, kermes and foundation cream.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2007100902091A CN100477983C (en) | 2007-04-13 | 2007-04-13 | Cosmetic prepared from cliff-grown tea and black goat embryo element |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2007100902091A CN100477983C (en) | 2007-04-13 | 2007-04-13 | Cosmetic prepared from cliff-grown tea and black goat embryo element |
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| Publication Number | Publication Date |
|---|---|
| CN101023916A true CN101023916A (en) | 2007-08-29 |
| CN100477983C CN100477983C (en) | 2009-04-15 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103720634A (en) * | 2012-10-16 | 2014-04-16 | 李丹榕 | Facial cleanser |
| CN104490677A (en) * | 2014-12-10 | 2015-04-08 | 唯美度科技（北京）有限公司 | Lipidosome essence emulsion and preparation method thereof |
| CN104922007A (en) * | 2014-03-19 | 2015-09-23 | 无锡康健因生命科学技术研究院有限公司 | Wrinkle-removal essence |
| CN106176526A (en) * | 2016-08-12 | 2016-12-07 | 桂林市晟博科技服务有限公司 | A kind of biological medicine Skin whitening care cosmetics and preparation method thereof |
| WO2017133038A1 (en) * | 2016-02-03 | 2017-08-10 | 程雪娇 | Anti-ageing and moisture preservation gel and preparation method |
| CN111568838A (en) * | 2020-04-23 | 2020-08-25 | 浙江美姿婷化妆品有限公司 | Natural bamboo vinegar sheep placenta essence shampoo and preparation method thereof |
-
2007
- 2007-04-13 CN CNB2007100902091A patent/CN100477983C/en active Active
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103720634A (en) * | 2012-10-16 | 2014-04-16 | 李丹榕 | Facial cleanser |
| CN104922007A (en) * | 2014-03-19 | 2015-09-23 | 无锡康健因生命科学技术研究院有限公司 | Wrinkle-removal essence |
| CN104490677A (en) * | 2014-12-10 | 2015-04-08 | 唯美度科技（北京）有限公司 | Lipidosome essence emulsion and preparation method thereof |
| WO2017133038A1 (en) * | 2016-02-03 | 2017-08-10 | 程雪娇 | Anti-ageing and moisture preservation gel and preparation method |
| CN106176526A (en) * | 2016-08-12 | 2016-12-07 | 桂林市晟博科技服务有限公司 | A kind of biological medicine Skin whitening care cosmetics and preparation method thereof |
| CN111568838A (en) * | 2020-04-23 | 2020-08-25 | 浙江美姿婷化妆品有限公司 | Natural bamboo vinegar sheep placenta essence shampoo and preparation method thereof |
| CN111568838B (en) * | 2020-04-23 | 2022-11-18 | 浙江美姿婷化妆品有限公司 | Natural bamboo vinegar sheep placenta essence shampoo and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN100477983C (en) | 2009-04-15 |
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