CN110302086A - A kind of multiple-effect maintenance essence and its preparation process - Google Patents
A kind of multiple-effect maintenance essence and its preparation process Download PDFInfo
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- CN110302086A CN110302086A CN201910518665.4A CN201910518665A CN110302086A CN 110302086 A CN110302086 A CN 110302086A CN 201910518665 A CN201910518665 A CN 201910518665A CN 110302086 A CN110302086 A CN 110302086A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61Q19/08—Anti-ageing preparations
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Abstract
The invention discloses a kind of multiple-effect maintenance essence and its preparation processes, are related to cosmetic technical field, solve because cosmetics fundamentally cannot play good maintenance effect to skin when in use, and the problem for causing its whole maintenance ineffective.A kind of multiple-effect maintenance essence comprising following weight percentage components: hydrolysis Sodium Hyaluronate 0.01-0.05%；Sodium Hyaluronate 0.3-1.1%；Skin conditioning agent a group 0.5-1%；1,2- pentanediol 0.5-1.5%；Trehalose 1-3%；Glycine betaine 0.5-2%；Hydroxypropyl oxinane triol 1-3%；Small molecule tripeptides 1-3%；Carboxymethyl R-glucan sodium 0.1-0.5%；Propylene glycol 5-10%；- 26 1-4% of glycerin polyether；Hydroxyethyl cellulose 0.2-0.3%；Skin conditioning agent b group 0.2-0.8%；Deionized water surplus.Multiple-effect maintenance essence in the present invention after use, can snap action and good maintenance effect fundamentally can be played to skin in collagen, and to the compact of skin, maintenance, Antiageing effect can be greatly improved.
Description
Technical field
The present invention relates to cosmetic technical fields, more specifically, it relates to a kind of multiple-effect maintenance essence and its preparation work
Skill.
Background technique
Maintenance essence is a kind of skin care item, possesses careful, watery quality, can mildly and effectively reform skin pattern, make
Skin is submissive smooth, more effectively helps the absorption of subsequent whitening product.
A kind of humidity-preserving type is disclosed in the Chinese invention patent application file of Publication No. CN106726673A have repair
The stoste formula and its technique of multiple crease-resistant function, including the raw material according to following weight percent meter: Sodium Hyaluronate 0.8%-
1%；Hydrolyze hyaluronic acid 0.1%-0.2%；Antioxidant 0.3%-0.5%；Palmityl tripeptides -50.5%-1%；EGF
0.1%-0.2%；Deionized water 97.1%-98.2%.
In above-mentioned application documents, because the stability of EGF is fabulous, be not easy flowing of scattering at normal temperature, can with it is each in human body
Kind enzyme forms good coordinating effect, promotes the reparation and regeneration of impaired epidermis, reduces various types of wrinkles.But the damage of skin
For wound often by UV-induced, ultraviolet light can promote the activity of metalloprotein, make the degradation of collagen significantly faster than just
Speed when normal aging, and EGF is the tyrosine phosphorylation to stimulate epidermal growth factor receptor, reaches repairing hyperplasia flesh
Skin cells of superficial layer, it is weaker to the protective capability of collagen, good maintenance effect fundamentally cannot be played to skin, into
And the maintenance for causing it integrally to be played when in use is ineffective, it is, therefore, desirable to provide a kind of new scheme is above-mentioned to solve
Problem.
Summary of the invention
For in the prior art because cosmetics fundamentally cannot play good maintenance effect to skin when in use, and
The problem for causing its whole maintenance ineffective, the purpose of the present invention one be to provide a kind of multiple-effect maintenance essence, passes through addition
Hydroxypropyl oxinane triol, small molecule tripeptides and carboxymethyl R-glucan sodium, and it is made to play good compounding between each other
Synergistic effect fundamentally can play good maintenance effect to skin, and whole with good to solve the above technical problems
Good application effect.
To achieve the above object one, the present invention provides the following technical scheme that
A kind of multiple-effect maintenance essence, including following weight percentage components:
Hydrolyze Sodium Hyaluronate 0.01-0.05%；
Sodium Hyaluronate 0.3-1.1%；
Skin conditioning agent a group 0.5-1%；
1,2- pentanediol 0.5-1.5%；
Trehalose 1-3%；
Glycine betaine 0.5-2%；
Hydroxypropyl oxinane triol 1-3%；
Small molecule tripeptides 1-3%；
Carboxymethyl R-glucan sodium 0.1-0.5%；
Propylene glycol 5-10%；
Glycerin polyether -261-4%；
Hydroxyethyl cellulose 0.2-0.3%；
Skin conditioning agent b group 0.2-0.8%；
Deionized water surplus.
By using above-mentioned technical proposal, collagen is the main ingredient of skin corium connection tissue extracelluar matrix,
When skin is irradiated by ultraviolet light, collagen Dai Baihui is degraded, and forms microgroove on the surface of skin.Small molecule tripeptides is to possess solely
The small molecule tripeptides of display sequence, the mechanism that can simulate human body itself generate collagen by TGF-β, can not only be significant
Increase collagen, improve skin turgor, moreover it is possible to protect collagen from degradation, reduce various types wrinkle, and then make
Multiple-effect maintenance essence can play good compact, maintenance and Antiageing effect to skin.
Carboxymethyl R-glucan sodium has good water-soluble and bioactivity, can stimulate into the cell defence system
System to repair the cell being damaged in ultraviolet light, and can inhibit the generation of inflammation, play good maintenance effect to skin,
And it can also play good anti-wrinkle effect, increase the water content of skin, it being capable of effective careful skin.Hydroxypropyl tetrahydro pyrrole
Triol of muttering can act on each level of skin, adjust the living environment of cell, rebuild the support knot of young skin layer by layer
Structure participates in adjusting every physiological function such as metabolism, proliferation, differentiation of cell, to play anti-ageing next effect.Meanwhile hydroxypropyl
Oxinane triol can also act on true epidermis interconnecting piece, and be capable of the generation of stimulation collagen, play to skin good
The effect of compact, maintenance and anti-aging.
Hydroxypropyl oxinane triol, small molecule tripeptides and carboxymethyl R-glucan sodium can be played when being used in mixed way
Good compound synergic effect, can greatly enhance the degree of adhesion of epidermis dermis, promote epidermal cell new life differentiation, and help table
Skin regeneration and reparation, and it can also directly act on the collagen in skin, collagen can not only be inhibited in ultraviolet light
Under degradation speed, moreover it is possible to stimulate the generation for swashing collagen, and then it is good compact to play multiple-effect maintenance essence to skin,
Maintenance and Antiageing effect.Meanwhile three kinds of substances can also enhance the water holding capacity of skin when being used in compounding, and it is whole to improve skin
The vigor of body, and quickly can be absorbed and be utilized in skin, and then make multiple-effect maintenance essence integrally quality with higher.
Further preferably, the Sodium Hyaluronate is respectively the middle molecule hyalomitome of 0.1-0.6% by weight percent
The macromolecular Sodium Hyaluronate of sour sodium and 0.2-0.5% composition.
By using above-mentioned technical proposal, macromolecular Sodium Hyaluronate has excellent moisturizing and lubricity, and to skin
With good reparation and protective action, and middle numerator sodium hyaluronate has excellent retentivity, and can play sustained release, stabilization
The effect of emulsification.It selects macromolecular Sodium Hyaluronate and middle numerator sodium hyaluronate to be used in compounding, multiple-effect can be greatly improved and repaired
The sun-proof and skin injury repair of essence is protected, and activity caused by the irradiation of sunlight middle-ultraviolet lamp can be eliminated in skin surface
Oxygen radical, protects the skin from the injury of ultraviolet light, at the same can also by promoting the proliferation and differentiation of epidermal cell, promote by
The skin regeneration of traumatic part position, and good compact, maintenance and Antiageing effect are played to skin.
Further preferably, the skin conditioning agent a group includes 1,2- hexylene glycol, decoyl hydroximic acid and butanediol.
By using above-mentioned technical proposal, 1,2- hexylene glycol has the outstanding height persistently outstanding anti-oxidant effect of moisturizing power agent
Fruit, and the surface tension and viscosity of multiple-effect maintenance essence can be improved, be conducive to the application effect for improving multiple-effect maintenance essence；Decoyl
Hydroximic acid is a kind of good organic acid, has good antibacterial and bacteriostasis in neutral conditions, and can be played good
Anti-corrosion effect, meanwhile, decoyl hydroximic acid can also play solubilized dissolution assistant effect, and have good complexing power, be conducive to make
Each component is sufficiently mixed, and improves the overall quality of multiple-effect maintenance essence；Butanediol is a kind of good moisturizer and solvent, and
With certain bacteriostasis；And the skin conditioning agent a group being made of 1,2- hexylene glycol, decoyl hydroximic acid and butanediol is added,
The using effect that multiple-effect maintenance essence can be greatly improved plays stable compact, maintenance and Antiageing effect to skin.
Further preferably, the skin conditioning agent b group includes bacillus/fermented soybean product extract, folic acid, fourth
Glycol, 1,2- hexylene glycol and Sodium Hyaluronate.
By using above-mentioned technical proposal, bacillus/fermented soybean product extract moment goes directly flesh bottom, makes in skin
Portion forms a kind of Compound Water ion magnetic field, circulation-supplied moisture, lasting effective moisturizing, and can strengthen skin self-regulating function,
Skin wettability is promoted, keeps skin more compact, and be not easy aging.Folic acid is the necessity of human body when using sugar and amino acid
Substance, be body cell growth and breeding needed for substance, can snap action in the reparation of damaged skin, improve multiple-effect
The maintenance ability of maintenance essence entirety.1,2- hexylene glycol, butanediol and Sodium Hyaluronate all have good moisture-retaining capacity, and have
Conducive to being sufficiently mixed each component raw material.And it is added by bacillus/fermented soybean product extract, folic acid, butanediol, 1,2-
The skin conditioning agent b group of hexylene glycol and Sodium Hyaluronate composition is conducive to improve multiple-effect maintenance essence to the compact of skin, maintenance
And Antiageing effect.
Further preferably, the small molecule tripeptides selects palmityl tripeptides -1, tripeptides -2, palmityl tripeptides -5, palm
Any one in acyl tripeptides -8, palmityl tripeptides -38, tripeptides -32, tripeptides -33 and palmityl tripeptides -40.
By using above-mentioned technical proposal, small molecule tripeptides be as three amino acid by peptide bond it is connected to each other made of it is small
Molecular compound, molecular weight is small, typically not greater than 500Da, is easy to be absorbed by the skin, and palmityl tripeptides -1, tripeptides -2, palm fibre
Palmitic acid acyl tripeptides -5, palmityl tripeptides -8, palmityl tripeptides -38, tripeptides -32, tripeptides -33 and palmityl tripeptides -40 can answer
It for cosmetic industry, can promote the synthesis of collagen and elastin laminin in skin corium, be conducive to promote skin bullet
Property, so that skin is restored smooth compact, and reduce wrinkle of skin.Meanwhile between above-mentioned small molecule tripeptides and other each component raw materials
With good compatibility, it can guarantee the stability of multiple-effect maintenance essence overall efficacy.
Further preferably, it is 0.4-0.6%'s that weight percent is additionally added in the component of the multiple-effect maintenance essence
Function additive, function additive includes usnic acid sodium and eriodictyol, and the ratio of usnic acid sodium and eriodictyol is 1:(3-5).
By using above-mentioned technical proposal, usnic acid sodium has good anti-corrosion, anti-inflammatory and oxidation resistance, can be fast
Speed acts on the skin part of ultraviolet injury, inhibits the degradation speed of collagen, and accelerates the differentiation of damaged tissues cell
Growth, and then good quick maintenance effect is played to damaged skin.Eriodictyol has good anti-inflammatory and oxidation resistance, mentions
Protective capacities of the high skin to ultraviolet light.Meanwhile usnic acid sodium and eriodictyol mix when being used as function additive, can play good
Compound synergic effect, react the immunological regulation at skin damage position and greatly enhance, and promote the composition of collagen tissue, in turn
Multiple-effect maintenance essence is greatly improved to the compact of skin, maintenance and Antiageing effect, makes multiple-effect maintenance essence that there is good application
Effect.
Further preferably, it is 0.1-0.3%'s that weight percent is additionally added in the component of the multiple-effect maintenance essence
Plant extracts, plant extracts select glycyrrhiza glabra extract, calendula extract, bermuda lily flower extract, polygoni cuspidati,radix
One of extract, Gotu Kola P.E, radix scutellariae root extract and tea extract are a variety of.
By using above-mentioned technical proposal, glycyrrhiza glabra extract has good inhibiting effect to the formation of melanin；
Calendula extract can prevent pigementation, promote skin gloss and elasticity, delaying senility, avoid the raw wrinkle of skin relaxation；It is white
Flower Flos Lilii viriduli extract can play the effect of whitening；Polygonum cuspidate root extract, tea extract and rosemary flower extract have
Good anti-oxidant, anti-aging effect；Gotu Kola P.E can promote collagen in skin corium to be formed, and make fibrin
Regeneration, reconnect get up, are inherently eliminated mother's line, achieve the effect that skin compact smooth；Radix scutellariae root extract and
German chamomile extract can promote the calmness of human facial skin to releive；Tea extract is able to suppress the oxidation of skin histology, dimension
Hold the compact of skin.
The purpose of the present invention two is to provide a kind of preparation process of multiple-effect maintenance essence, using the multiple-effect of technique preparation
Maintenance essence fundamentally can play good maintenance effect to skin, and whole with good application effect.
To achieve the above object two, the present invention provides following technical solutions, comprising the following steps:
Step 1 premixes A phase, takes deionized water, the hydrolysis Sodium Hyaluronate, Sodium Hyaluronate, skin of corresponding weight percent
Conditioner a group and 1,2- pentanediol are sequentially weighed into after persistently stirring 5-10min in emulsion pot, after standing 8-10 hours, are stirred for
12-18min, mixing speed 30-50rpm, is dispersed to uniform liquid；
Step 2, emulsification mixing, takes the trehalose, glycine betaine, hydroxypropyl oxinane triol, small molecule of corresponding weight percent
Tripeptides, carboxymethyl R-glucan sodium, propylene glycol, glycerin polyether -26, hydroxyethyl cellulose and skin conditioning agent b group, sequentially add
Into the emulsion pot containing A phase, it is dispersed with stirring 8-10min, mixing speed 30-50rpm, until it is uniform, multiple-effect can be obtained and repair
Protect essence.
In conclusion compared with prior art, the invention has the following advantages:
(1) hydroxypropyl oxinane triol, small molecule tripeptides and carboxymethyl R-glucan sodium is added, and it is good multiple to play it
With synergistic effect, and the collagen in skin can be directly acted on, the drop of collagen under ultraviolet light can not only be inhibited
Solve speed, moreover it is possible to stimulate the generation for swashing collagen, and then it is good compact to play multiple-effect maintenance essence to skin, maintenance and
Antiageing effect；
(2) it selects macromolecular Sodium Hyaluronate and middle numerator sodium hyaluronate to be used in compounding, multiple-effect maintenance essence can be greatly improved
The sun-proof and skin injury repair of China, and sunlight middle-ultraviolet lamp can be eliminated in skin surface and irradiate generated active oxygen certainly
By base, the injury of ultraviolet light is protected the skin from, while can also be promoted by the proliferation and differentiation of promotion epidermal cell by traumatic part
The skin regeneration of position, and good compact, maintenance and Antiageing effect are played to skin；
(3) function additive of usnic acid sodium and eriodictyol composition is added, the immunological regulation at skin damage position is not only made to react big
Big enhancing, plays quick maintenance effect, moreover it is possible to promote the composition of collagen tissue, and then greatly improve multiple-effect maintenance essence to skin
Compact, maintenance and the Antiageing effect of skin make multiple-effect maintenance essence have good application effect.
Detailed description of the invention
Fig. 1 is the preparation technology flow chart of multiple-effect maintenance essence in the present invention.
Specific embodiment
With reference to the accompanying drawings and examples, the present invention will be described in detail.
Embodiment 1: a kind of multiple-effect maintenance essence, each component and its corresponding weight percent are as shown in table 1, and by such as
Lower step prepares:
Step 1 premixes A phase, takes deionized water, the hydrolysis Sodium Hyaluronate, Sodium Hyaluronate, skin of corresponding weight percent
Conditioner a group and 1,2- pentanediol are sequentially weighed into after persistently stirring 5min in emulsion pot, after standing 5 hours, are stirred for 15min,
Mixing speed is 30rpm, is dispersed to uniform liquid；
Step 2, emulsification mixing, takes the trehalose, glycine betaine, hydroxypropyl oxinane triol, small molecule of corresponding weight percent
Tripeptides, carboxymethyl R-glucan sodium, propylene glycol, glycerin polyether -26, hydroxyethyl cellulose and skin conditioning agent b group, sequentially add
Into the emulsion pot containing A phase, it is dispersed with stirring 8min, mixing speed 30rpm, until it is uniform, multiple-effect maintenance essence can be obtained.
Note: in above-mentioned steps one Sodium Hyaluronate by weight percent be respectively 0.6% middle numerator sodium hyaluronate and
0.5% macromolecular Sodium Hyaluronate composition；Skin conditioning agent a group include weight percent be 0.1% 1,2- hexylene glycol,
0.3% decoyl hydroximic acid and 0.1% butanediol；It is 0.2% that skin conditioning agent b group, which includes weight percent, in step 2
Bacillus/fermented soybean product extract, 0.2% folic acid, 0.1% butanediol, 0.2% 1,2- hexylene glycol and
0.1% Sodium Hyaluronate, Sodium Hyaluronate select micromolecule hyaluronic acid sodium；Small molecule tripeptides selects palmityl tripeptides -5.
Embodiment 2-8: a kind of multiple-effect maintenance essence, difference from example 1 is that, each component and its corresponding weight
It is as shown in table 1 to measure percentage.
Each component and its weight percent in 1 embodiment 1-8 of table
Embodiment 9: a kind of multiple-effect maintenance essence, difference from example 1 is that, the choosing of two small molecular tripeptides of above-mentioned steps
With palmityl tripeptides -1.
Embodiment 10: a kind of multiple-effect maintenance essence, difference from example 1 is that, two small molecular of above-mentioned steps
Tripeptides selects palmityl tripeptides -8.
Embodiment 11: a kind of multiple-effect maintenance essence, difference from example 1 is that, in step 1, skin conditioning agent
A group includes 1,2- hexylene glycol, 0.2% decoyl hydroximic acid and 0.1% butanediol that weight percent is 0.2%.
Embodiment 12: a kind of multiple-effect maintenance essence, difference from example 1 is that, in step 1, skin conditioning agent
A group includes 1,2- hexylene glycol, 0.1% decoyl hydroximic acid and 0.1% butanediol that weight percent is 0.3%.
Embodiment 13: a kind of multiple-effect maintenance essence, difference from example 1 is that, in step 1, skin conditioning agent
A group includes 1,2- hexylene glycol, 0.1% decoyl hydroximic acid and 0.3% butanediol that weight percent is 0.1%.
Embodiment 14: a kind of multiple-effect maintenance essence, difference from example 1 is that, skin conditioning agent b in step 2
Group include weight percent be 0.3% bacillus/fermented soybean product extract, 0.2% folic acid, 0.1% fourth two
Alcohol, 0.1% 1,2- hexylene glycol and 0.1% Sodium Hyaluronate, Sodium Hyaluronate select micromolecule hyaluronic acid sodium.
Embodiment 15: a kind of multiple-effect maintenance essence, difference from example 1 is that, skin conditioning agent b in step 2
Group include weight percent be 0.4% bacillus/fermented soybean product extract, 0.1% folic acid, 0.1% fourth two
Alcohol, 0.1% 1,2- hexylene glycol and 0.1% Sodium Hyaluronate, Sodium Hyaluronate select micromolecule hyaluronic acid sodium.
Embodiment 16: a kind of multiple-effect maintenance essence, difference from example 1 is that, skin conditioning agent b in step 2
Group include weight percent be 0.2% bacillus/fermented soybean product extract, 0.3% folic acid, 0.1% fourth two
Alcohol, 0.1% 1,2- hexylene glycol and 0.1% Sodium Hyaluronate, Sodium Hyaluronate select micromolecule hyaluronic acid sodium.
Embodiment 17: a kind of multiple-effect maintenance essence, difference from example 1 is that, step 2 is specifically configured to, cream
Change mixing, take corresponding weight percent be 1% trehalose, 0.5% glycine betaine, 0.5% hydroxypropyl oxinane triol,
1% small molecule tripeptides, 0.1% carboxymethyl R-glucan sodium, 5% propylene glycol, 4% glycerin polyether -26,0.2%
Hydroxyethyl cellulose, 0.8% skin conditioning agent b group and 0.5% function additive, the sunglo that function additive is 1:4 by ratio
Sour sodium and eriodictyol composition, then join it into the emulsion pot containing A phase, are dispersed with stirring 8min, mixing speed is
30rpm, until it is uniform, multiple-effect maintenance essence can be obtained.
Embodiment 18: a kind of multiple-effect maintenance essence, difference from example 1 is that, step 2 is specifically configured to, cream
Change mixing, take corresponding weight percent be 1% trehalose, 0.5% glycine betaine, 0.5% hydroxypropyl oxinane triol,
1% small molecule tripeptides, 0.1% carboxymethyl R-glucan sodium, 5% propylene glycol, 4% glycerin polyether -26,0.2%
Hydroxyethyl cellulose, 0.8% skin conditioning agent b group and 0.4% function additive, the sunglo that function additive is 1:3 by ratio
Sour sodium and eriodictyol composition, then join it into the emulsion pot containing A phase, are dispersed with stirring 8min, mixing speed is
30rpm, until it is uniform, multiple-effect maintenance essence can be obtained.
Embodiment 19: a kind of multiple-effect maintenance essence, difference from example 1 is that, step 2 is specifically configured to, cream
Change mixing, take corresponding weight percent be 1% trehalose, 0.5% glycine betaine, 0.5% hydroxypropyl oxinane triol,
1% small molecule tripeptides, 0.1% carboxymethyl R-glucan sodium, 5% propylene glycol, 4% glycerin polyether -26,0.2%
Hydroxyethyl cellulose, 0.8% skin conditioning agent b group and 0.6% function additive, the sunglo that function additive is 1:5 by ratio
Sour sodium and eriodictyol composition, then join it into the emulsion pot containing A phase, are dispersed with stirring 8min, mixing speed is
30rpm, until it is uniform, multiple-effect maintenance essence can be obtained.
Embodiment 20: a kind of multiple-effect maintenance essence, difference from example 1 is that, step 2 is specifically configured to, cream
Change mixing, take corresponding weight percent be 1% trehalose, 0.5% glycine betaine, 0.5% hydroxypropyl oxinane triol,
1% small molecule tripeptides, 0.1% carboxymethyl R-glucan sodium, 5% propylene glycol, 4% glycerin polyether -26,0.2%
Hydroxyethyl cellulose, 0.8% skin conditioning agent b group and 0.2% plant extracts, plant extracts select glycyrrhiza glabra to mention
Object is taken, is then joined it into the emulsion pot containing A phase, 8min, mixing speed 30rpm are dispersed with stirring, until it is uniform,
Multiple-effect maintenance essence can be obtained.
Embodiment 21: a kind of multiple-effect maintenance essence, difference from example 1 is that, step 2 is specifically configured to, cream
Change mixing, take corresponding weight percent be 1% trehalose, 0.5% glycine betaine, 0.5% hydroxypropyl oxinane triol,
1% small molecule tripeptides, 0.1% carboxymethyl R-glucan sodium, 5% propylene glycol, 4% glycerin polyether -26,0.2%
Hydroxyethyl cellulose, 0.8% skin conditioning agent b group and 0.1% plant extracts, it is 1:1 that plant extracts, which selects ratio,
Calendula extract and bermuda lily flower extract, then join it into the emulsion pot containing A phase, be dispersed with stirring
8min, mixing speed 30rpm, until it is uniform, multiple-effect maintenance essence can be obtained.
Embodiment 22: a kind of multiple-effect maintenance essence, difference from example 1 is that, step 2 is specifically configured to, cream
Change mixing, take corresponding weight percent be 1% trehalose, 0.5% glycine betaine, 0.5% hydroxypropyl oxinane triol,
1% small molecule tripeptides, 0.1% carboxymethyl R-glucan sodium, 5% propylene glycol, 4% glycerin polyether -26,0.2%
Hydroxyethyl cellulose, 0.8% skin conditioning agent b group and 0.3% plant extracts, it is 1:1 that plant extracts, which selects ratio:
1 Gotu Kola P.E, radix scutellariae root extract and tea extract, then joins it into the emulsion pot containing A phase,
It is dispersed with stirring 8min, mixing speed 30rpm, until it is uniform, multiple-effect maintenance essence can be obtained.
Comparative example 1: a kind of multiple-effect maintenance essence, difference from example 1 is that, step 2 is specifically configured to, cream
Change mixing, taking corresponding weight percent is 1% trehalose, 0.5% glycine betaine, 1% small molecule tripeptides, 0.1% carboxylic
Methyl beta glucan sodium, 5% propylene glycol, 4% glycerin polyether -26,0.2% hydroxyethyl cellulose and 0.8% skin
Conditioner b group is added sequentially in the emulsion pot containing A phase, is dispersed with stirring 8min, mixing speed 30rpm, until it is uniform, i.e.,
Multiple-effect maintenance essence can be obtained.
Comparative example 2: a kind of multiple-effect maintenance essence, difference from example 1 is that, step 2 is specifically configured to, cream
Change mixing, take corresponding weight percent be 1% trehalose, 0.5% glycine betaine, 0.5% hydroxypropyl oxinane triol,
0.1% carboxymethyl R-glucan sodium, 5% propylene glycol, 4% glycerin polyether -26,0.2% hydroxyethyl cellulose and
0.8% skin conditioning agent b group, is added sequentially in the emulsion pot containing A phase, is dispersed with stirring 8min, mixing speed is
30rpm, until it is uniform, multiple-effect maintenance essence can be obtained.
Comparative example 3: a kind of multiple-effect maintenance essence, difference from example 1 is that, step 2 is specifically configured to, cream
Change mixing, take corresponding weight percent be 1% trehalose, 0.5% glycine betaine, 0.5% hydroxypropyl oxinane triol,
1% small molecule tripeptides, 5% propylene glycol, 4% glycerin polyether -26,0.2% hydroxyethyl cellulose and 0.8% skin
Conditioner b group is added sequentially in the emulsion pot containing A phase, is dispersed with stirring 8min, mixing speed 30rpm, until it is uniform, i.e.,
Multiple-effect maintenance essence can be obtained.
Comparative example 4: a kind of multiple-effect maintenance essence, difference from example 1 is that, step 2 is specifically configured to, cream
Change mixing, taking corresponding weight percent is 1% trehalose, 0.5% glycine betaine, 5% propylene glycol, 4% glycerin polyether-
26,0.2% hydroxyethyl cellulose and 0.8% skin conditioning agent b group, be added sequentially in the emulsion pot containing A phase, stir
Disperse 8min, mixing speed 30rpm, until it is uniform, multiple-effect maintenance essence can be obtained.
Performance test
Test specimen: using the multiple-effect maintenance essence obtained in embodiment 1-22 as test specimen 1-22, using comparative example 1-4
The multiple-effect maintenance essence of middle acquisition is as control sample 1-4.
Test method: randomly selecting 260 people of women of 28-45 years old age bracket, and be randomly divided into 26 groups, every group of each 10 people,
Then using totally 3 courses for the treatment of, each course for the treatment of 7 days, each course for the treatment of are more using equivalent in test specimen 1-22 and control sample 1-4
Maintenance essence is imitated, and is uniformly applied to face in use, is gently massaged into and fully absorbs.Effect, skin are dispelled to microgroove
Tightening effect and anti-ageing effect carry out applicating evaluating, and 10 points to represent effect best, and 1 point to represent effect worst.
Test result: the test result of test specimen 1-22 and control sample 1-4 are as shown in table 2.As shown in Table 2, by trying
Test sample 1-8 and control sample 1-4 test result control can obtain, be added hydroxypropyl oxinane triol, small molecule tripeptides and
Carboxymethyl R-glucan sodium can be improved multiple-effect maintenance essence and play good compact, maintenance and Antiageing effect to skin, and
When it is used in mixed way, the effect played is best.It can be obtained by the control of the test result of test specimen 9-16 and test specimen 1-8,
Skin conditioning agent a group, skin conditioning agent b group and small molecule tripeptides presently disclosed and select are suitable for multiple-effect maintenance essence
The preparation of China.It is compareed can be obtained respectively by the test result of test specimen 17-19, test specimen 20-22 and test specimen 1-8, added
Enter the function additive or plant extracts being made of usnic acid sodium and eriodictyol, can improve multiple-effect maintenance essence and skin is played
It is good compact, maintenance and Antiageing effect, and promotion caused by the function additive being made of usnic acid sodium and eriodictyol is added
Effect is best.
The test result of table 2 test specimen 1-22 and control sample 1-4
The above is only a preferred embodiment of the present invention, protection scope of the present invention is not limited merely to above-described embodiment,
All technical solutions belonged under thinking of the present invention all belong to the scope of protection of the present invention.It should be pointed out that for the art
For those of ordinary skill, several improvements and modifications without departing from the principles of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (8)
1. a kind of multiple-effect maintenance essence, which is characterized in that including following weight percentage components:
Hydrolyze Sodium Hyaluronate 0.01-0.05%；
Sodium Hyaluronate 0.3-1.1%；
Skin conditioning agent a group 0.5-1%；
1,2- pentanediol 0.5-1.5%；
Trehalose 1-3%；
Glycine betaine 0.5-2%；
Hydroxypropyl oxinane triol 1-3%；
Small molecule tripeptides 1-3%；
Carboxymethyl R-glucan sodium 0.1-0.5%；
Propylene glycol 5-10%；
- 26 1-4% of glycerin polyether；
Hydroxyethyl cellulose 0.2-0.3%；
Skin conditioning agent b group 0.2-0.8%；
Deionized water surplus.
2. multiple-effect maintenance essence according to claim 1, which is characterized in that the Sodium Hyaluronate is by weight percent score
It Wei not the middle numerator sodium hyaluronate of 0.1-0.6% and the macromolecular Sodium Hyaluronate composition of 0.2-0.5%.
3. multiple-effect maintenance essence according to claim 1, which is characterized in that the skin conditioning agent a group include 1,2- oneself
Glycol, decoyl hydroximic acid and butanediol.
4. multiple-effect maintenance essence according to claim 1, which is characterized in that the skin conditioning agent b group includes gemma bar
Bacterium/fermented soybean product extract, folic acid, butanediol, 1,2- hexylene glycol and Sodium Hyaluronate.
5. multiple-effect maintenance essence according to claim 1, which is characterized in that the small molecule tripeptides selects palmityl three
Peptide -1, tripeptides -2, palmityl tripeptides -5, palmityl tripeptides -8, palmityl tripeptides -38, tripeptides -32, tripeptides -33 and palmityl three
Any one in peptide -40.
6. multiple-effect maintenance essence according to claim 1, which is characterized in that also add in the component of the multiple-effect maintenance essence
Entering to have weight percent is the function additive of 0.4-0.6%, and function additive includes usnic acid sodium and eriodictyol, and usnic acid sodium and
The ratio of eriodictyol is 1:(3-5).
7. multiple-effect maintenance essence according to claim 1, which is characterized in that also add in the component of the multiple-effect maintenance essence
Entering to have weight percent is the plant extracts of 0.1-0.3%, and plant extracts selects glycyrrhiza glabra extract, pot marigold to extract
One in object, bermuda lily flower extract, polygonum cuspidate root extract, Gotu Kola P.E, radix scutellariae root extract and tea extract
Kind is a variety of.
8. a kind of preparation process of multiple-effect maintenance essence as described in claim 1, which comprises the following steps:
Step 1 premixes A phase, takes deionized water, the hydrolysis Sodium Hyaluronate, Sodium Hyaluronate, skin of corresponding weight percent
Conditioner a group and 1,2- pentanediol are sequentially weighed into after persistently stirring 5-10min in emulsion pot, after standing 8-10 hours, are stirred for
12-18min, mixing speed 30-50rpm, is dispersed to uniform liquid；
Step 2, emulsification mixing, takes the trehalose, glycine betaine, hydroxypropyl oxinane triol, small molecule of corresponding weight percent
Tripeptides, carboxymethyl R-glucan sodium, propylene glycol, glycerin polyether -26, hydroxyethyl cellulose and skin conditioning agent b group, sequentially add
Into the emulsion pot containing A phase, it is dispersed with stirring 8-10min, mixing speed 30-50rpm, until it is uniform, multiple-effect can be obtained and repair
Protect essence.
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| CN111135162A (en) * | 2020-01-02 | 2020-05-12 | 上海中医药大学 | Usnea acid photodegradable product and application thereof in preparation of ultraviolet radiation resistant medicines, cosmetics or health care products |
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| CN112402310A (en) * | 2020-10-30 | 2021-02-26 | 广州市妆妍生物技术有限公司 | Vitreous chromogen polypeptide anti-wrinkle eye cream and preparation method thereof |
| CN112426379A (en) * | 2021-01-11 | 2021-03-02 | 点亮星空(杭州)科技有限公司 | Preparation method of polypeptide wrinkle-removing repair essence |
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