CN105193673B - A kind of clear acne repairs liquid and preparation method thereof - Google Patents
A kind of clear acne repairs liquid and preparation method thereof Download PDFInfo
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- CN105193673B CN105193673B CN201510713649.2A CN201510713649A CN105193673B CN 105193673 B CN105193673 B CN 105193673B CN 201510713649 A CN201510713649 A CN 201510713649A CN 105193673 B CN105193673 B CN 105193673B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
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- A61Q19/00—Preparations for care of the skin
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A61Q19/008—Preparations for oily skin
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Abstract
The present invention relates to a kind of clear acnes to repair liquid comprising contains following components by percentage to the quality: licorice root extract 0.5-5%, dandelion extract 0.5-5%, honeysuckle flower extract 0.5-5%, radix scutellariae root extract 0.5-5%, kuh-seng root extract 0.5-5%, Porcine HGF 0.0001-0.001%, house oil 2-5%, castor oil 3-6%, ethyl alcohol 2-3%, glycerol 5-10%, propylene glycol 5-10%, surfactant 1-5%, preservative 0.01-0.6%, water surplus；Wherein each Chinese medical extract, Porcine HGF, house oil reasonable compatibility are as skin repair agent; collaboration to play anti-inflammatory antibacterial; adjust fat secretion; promote cell neogenesis and reconstruction; achieve the purpose that the light trace of anti-acne; invention also provides preparation method, the activity of effective component, keeps the light trace effect of its anti-acne more significant in effective protection prescription.
Description
Technical field
The present invention relates to cosmetic technical fields more particularly to a kind of clear acne to repair liquid and preparation method thereof.
Background technique
In modern economic society, due to the variation of living environment, the harmful chemicals that contain in interior decoration material at
The factors such as part, easily hair whelk (acne), serious to go back erubescence swell and itch, the course of disease is the more than ten years, becomes obstinate
Chronic disease, even acne disappears, the acne print and dent left is also annoyed, to this skin problem, existing various mouths
Medication, either Chinese patent drug is still boiled medicine, and effect is unobvious, also adds the burden of stomach.That sees currently on the market goes
There are many acne drug and cosmetics, belong to chemically product mostly, and price is high, and effect is slow or unobvious, uses time length, healing
Rate is low, high recurrence rate, often there is side effect after use.Since treatment is not thorough, often scar, brings for a long time to patient
Spirit and the human body pain.
Therefore need overcome the deficiencies in the prior art, develop one kind can not only effective anti-acne, and acne is not stayed after anti-acne
The anti-acne skin care item of trace seem most important.
Summary of the invention
It is an object of the invention to overcome the deficiencies of existing technologies, a kind of clear acne is provided and repairs liquid and preparation method, no
Only anti-acne effect is good, and pockmark is not stayed after anti-acne.
To achieve the goals above, the technical solution adopted by the present invention is as follows:
Technical solution one:
A kind of clear acne reparation liquid comprising contain following components by percentage to the quality:
As further improvement of the invention, the Porcine HGF is selected from keratinocyte growth factor, acidity into fibre
Tie up one of Porcine HGF, basic fibroblast growth factor, platelet derived growth factor and epidermal growth factor or
It is several；
The surfactant is selected from one or more of glycerin polyether -26, laurel glycol ethers, coceth -7；
The preservative is Phenoxyethanol.
As further improvement of the present invention comprising contain following components by percentage to the quality:
Technical solution two:
A kind of clear acne described in a kind of technical solution one repairs the preparation method of liquid, which is characterized in that specifically includes as follows
Step:
Step 1: weighing each component by above-mentioned mass percent proportion；
Step 2: house oil is heated to 40-50 DEG C of thawing, Porcine HGF is then added, it is cold rapidly after being uniformly dispersed
But it is solidified to house oil, obtains cell factor-house oil lotion；
Step 3: castor oil, glycerol, propylene glycol, surfactant, water are added in emulsion tank, it is emulsified in 80-90 DEG C
30min；After being cooled to 40-50 DEG C, be added ethyl alcohol, preservative, licorice root extract, dandelion extract, honeysuckle flower extract,
Radix scutellariae root extract, kuh-seng root extract, continue after emulsifying 10min, are cooled to≤20 DEG C, and it is resulting thin that step 2 is then added
Intracellular cytokine-house oil paste, in≤20 DEG C stirring to be uniformly dispersed to get.
As further improvement of the invention, the water is deionized water.
As further improvement of the invention, the ethyl alcohol is dehydrated alcohol.
In the present invention:
Licorice root extract: containing a variety of chemical components such as glycyrrhizic acid, liquiritin, chromocor compound, can not only lead to
It crosses the activity of inhibition tyrosinase and dopachrome interconvertible enzyme (TRP-2), hinder the polymerization of 5,6- dihydroxy indole (DHl), with
This prevents the formation of melanin, to achieve the effect that skin whitening；The molecule of high energy UV can also be absorbed, from
Then ground state transition returns to ground state from activated state again to activated state, release harmless low energy ray, achievees the effect that sun-proof.
Dandelion extract: containing a variety of active ingredients such as flavone compound, chlorogenic acid, SOD enzymes, have extremely strong anti-
Bacterium antiinflammation improves metabolism status of the free radical in skin histology, alleviates superoxide radical to the thorn of skin histology
Sharp and inflammation damnification, keeps acne symptom substantially reduced, and accelerate the reparation of cutaneous lesion and lesion.And active material therein
It can penetrate into skin histology, excitation endogenous SOD activity improves, by dandelion SOD contained by its own and had class
SOD sample effect, these effects collaboration, mutual aid synergy mutually, can remove superoxide radical to the maximum extent, inhibit unsaturated fat
The oxidation course of acid, to reduce pigmented occurrence and development.
Honeysuckle flower extract: also known as Honegsukle flower P.E, have to Propiobacterium, staphylococcus aureus and Pseudomonas aeruginosa
Good inhibiting effect, being capable of antibacterial anti-inflammatory；Furthermore life of the honeysuckle flower extract also to the increment of epidermal keratinocyte, cholesterol
At and the generation of moisturizing factor have good facilitation, be capable of the water and oil balance of conditioning skin, increase the bullet of skin
Property, improve the drying problem of skin.
Radix scutellariae root extract: main active scutelloside, the inhibition to elastoser and the rush to interferon secretion
Into and effect of scavenging radical, triplicity reacted Baical Skullcap root P.E have increase skin metabolism, increase skin
The effect of elasticity and antiallergic.In addition, Baical Skullcap root P.E illustrates the facilitation of activation and interferon secretion to luciferase,
Baical Skullcap root P.E has effect to the resistance for inhibiting dermatitis, enhancing skin, has anti-inflammatory；Baical Skullcap root P.E can neutralize release
Histamine shows that it has prevention and control capability to release group amine type allergy.
Kuh-seng root extract: main active matrine, can Bergamot Mint Extract, dredge and restrain pore, remove
Skin endotoxin contamination, book on Chinese herbal medicine nutrition abundant, promotes the growth and reparation of damaged blood vessels nerve cell, restores subcutaneous blood capillary
Solencyte vigor, skin reproduction is compact fine and smooth, plays the role of beauty and skin care.
Porcine HGF: including acid fibroblast growth factor (AFGF), basic fibroblast growth factor
(BFGF), epithelical cell growth factor (EGF), keratinocyte growth factor (KGF-2) and platelet derived growth factor (PDGF)
Deng, several factors compounding can promotion skin texture from inside to outside improvement, accelerate skin repair speed, reduce scar and produce
It is raw.
Epithelical cell growth factor can stimulate epithelial cell and endothelial cell growth, grow up to new epidermal cell constantly,
Dead skin layer is pushed and is gradually fallen off, keeps skin delicacy smooth.Promote the metabolism of the various cells of skin simultaneously, enhancing is thin
Born of the same parents absorb nutriment.Promote collagen and collagen enzymatic synthesis, it is fine to adjust collagen for secretion Collagen material, hyaluronic acid and glycoprotein
Dimension has and moisturizes the skin, enhances skin elasticity, reduces wrinkle of skin and prevents the effect of skin aging.Have in beauty circle " beautiful
The title of the factor ".
Acid fibroblast growth factor is a kind of multifunctional powerful cell factor, to the fibroblastic metabolism of promotion
Formation with collagen plays critical function；It can promote the growth and breeding of skin histology, it passes through special with cell surface
Receptor combines, and regulates and controls skin epidermis, and division, breeding and the Growth and Differentiation of endothelium and stroma cell promote cell metabolism, enhances oxygen
Change effect；Can promote cell related with skin injury mushrooms out breeding, and adjusts the synthesis of intercellular matrix, secretes and divide
Solution；It can promote the regeneration of corneocyte, accelerate the reparation of keratoderma and hypothallus, promote the life of human skin cell
It is long；The synthesis and cell metabolism of the protein of Skin Cell can be enhanced, with delaying skin cell ageing, promote epidermal cell
Reparation and growth, keep skin smooth plump.
Basic fibroblast growth factor is existing a kind of denier cyclin in human body, it can promote more
On the one hand the growth and differentiation of kind cell adjust and balance endocrine by the variation of blood vessel, nerve and body fluid, be excited into fibre
Tie up the increment of mother cell and promote it is more plain increase and various related substances, such as a variety of amino acid, elastin laminin, collagen
Deng increase, maintain the normal function and vigor of skin, make deformation fat cell be restored, vigor enhancing；Its again quilt
Referred to as corium growth factor, is primarily present in the keratinocyte of epidermal basal, be important promote cell mitogen because
Son and angiogenesis factor, it is living with extensive biology to a plurality of types of cells from mesoderm and neuroderm
Property, cell Proliferation, growth, differentiation can be promoted, promote angiogenesis, improve cell life microenvironment, promote injured nerve regeneration
And the reparation of blood vessel, muscle, skin etc., it reduces ultraviolet radiation and is damaged caused by skin, be neurotrophic and regeneration
The factor has the title of " cell activating agent ".
The growth and breeding of keratinocyte growth factor promotion skin histology；By regulating and controlling in conjunction with specific cell surface receptors
The division growth and Growth and Differentiation of skin epidermis, endothelium and stroma cell promote the metabolism of cell, enhance oxidation；Promote
With skin injury in relation to the rapid proliferation of cell, and adjusts the synthesis of intercellular matrix (such as collagen) and secrete and divide
Solution；To promote the regeneration of corneocyte, accelerate the reparation of keratoderma and basal layer, when tissue cultures, promotes human body
Skin epithelial cell growth；Enhance the synthesis and cell metabolism of the protein, RNA of epidermal cell；It declines with delaying skin cell
Always, the effect for promoting reparation and the growth of fell cell, keeps skin smooth plump.
Platelet derived growth factor is a kind of important factor,mitogenic, has stimulation specific cells group division growth
Ability promotes the generation of fibroblast, to repair the skin corium collagenous fibres fracture as caused by aging and damage and become
Shape promotes skin corium growth to be promoted with elasticity, keeps wrinkle naturally long flat.Promote collagen directly to synthesize in skin corium, more has
Effect delays senescence.Replenishing collagen is almost the common sense that each people seeking beauty both knows about now.However, how human body to be allowed more to fill
The absorption collagen divided is always the topic being difficult to resolve.PDGF can promote the activity of fibroblast and promote secretion collagen
Albumen.The collagen for promoting fibroblast to generate by PDGF more can effectively prolong than directly smearing or edible collagen
Slow skin aging.Promote subcutaneous capillary to be formed, repairs subcutaneous blood microcirculqtory system, provide sufficient nutrition for skin.Skin
One important reason of skin aging is exactly veins beneath the skin atrophy, and so as to cause skin blood supply insufficiency, therefore cell lacks nutrition, causes
The generation of wrinkle.Many growth factors participate in the Physiological effect of angiogenesis.Each serves most important wherein.Its
The regeneration vessel function of middle PDGF has obvious curative effects for anti-aging.Promote the growth and update of Skin Cell, promotes skin
The physiological activity and metabolism of tissue, enhance the immunity and self-repairing capability of Skin Cell, repair due to daylight,
Red capillary caused by severe cold, chemical substance and mechanical wear injure and sensitive skin keep Skin Cell more pale moist, fresh and alive
It is full, make facial colour spot obscure, the aging of withered and yellow drying assumes an entirely new aspect.
House oil: room temperature white solid, free from extraneous odour, acid value: < 1.0mgKOH/g, peroxide value: < 3.0meq/kg, saponification
Value: 195-199, iodine number: 72-86, melting point (freezing point): 36-43 DEG C, index of refraction (40 DEG C): 1.462, relative density (25 DEG C):
0.90-0.915, unsaturated fatty acid content reach 60% or more, and wherein polyunsaturated fatty acid relative amount is up to 24%
More than；Also containing relatively abundant VE and a certain amount of VA；The ingredient of horse fat fat and other animal tallows have obvious difference, contain
The active constituent of natural anti-oxidation performance is a kind of good natural；Its with moisturizing and moisten, anti-inflammatory releive,
Anti-oxidant, anti-acne, Bearberry Extract.
Castor oil: being the vegetable oil of unique energy in nature, the fatty acid composition contained by it is mainly castor-oil plant alcohol
Acid accounts for about 90%, with moisture retention, inoxidizability, does not stimulate mildly, for that can make skin soft comfortable in cosmetics.
Alcohols: ethyl alcohol can promote the osmotic absorption of active constituent, and glycerol, propylene glycol can keep skin as wetting agent
Water profit.
Methylisothiazolinone: being a kind of efficient germicide, heat-resisting waterborne preservative, can inhibit bacterium, fungi, mould
The growth of the microorganisms such as bacterium and mould.
Compared with prior art, obtained by the present invention to have the beneficial effect that:
1, licorice root extract, dandelion extract, honeysuckle flower extract, radix scutellariae root extract, radix sophorae in the present invention
Extract, Porcine HGF, house oil reasonable compatibility as skin repair agent, collaboration to play anti-inflammatory antibacterial, adjust grease point
It secretes, promotes cell neogenesis and reconstruction tissue, thus achieve the purpose that the light trace of anti-acne,.
2, due to Porcine HGF under solution state unstable, easy in inactivation, therefore the present invention during the preparation process will
Porcine HGF is scattered in house oil, is prepared into cell factor-house oil lotion, is then dispersed the lotion in skin care item,
The effective protection activity of cell factor, so that the small effect of the light trace of the clear acne of skin care item of the invention is more significant, storage life is also longer.
3, the present invention uses matrix of the house oil as dispersed encapsulated cell factor, the advantage is that, the freezing point of house oil is
36-43 DEG C, usually in refrigerator cold-storage, house oil cell factor can be isolated with other compositions of the skin care because in, in use, by it
It is applied to face, at the temperature of human body and massage effect, house oil is easy to melt, to discharge cell factor, and its strong infiltration
Property, it is easier to cell factor is brought to the bottom of skin into, to preferably play the light trace effect of anti-acne；In addition house oil itself also has
There is acne-removing inflammation-diminishing, plays effect in terms of the light trace of anti-acne.
Prescription cooperation science in the present invention, natural safety is without side-effects, acts synergistically between each component, effect Xiang Fuxiang
At, and in preparation method effective protection prescription effective component activity, so that clear acne produced by the present invention is repaired liquid in anti-acne
Significant effect in terms of light trace, while also extending the shelf-life of facial treatment milk.
Specific embodiment
Licorice root extract: it is purchased from Xi'an Yuan Sen Biotechnology Co., Ltd；
Dandelion extract: it is purchased from Xi'an Jin Lv biotechnology Co., Ltd
Honeysuckle flower extract: it is purchased from Xi'an Yuan Sen Biotechnology Co., Ltd
Radix scutellariae root extract: Xi'an Rayleigh Biotechnology Co., Ltd
Kuh-seng root extract: Shaanxi Kang Yue Biotechnology Co., Ltd
Basic fibroblast growth factor: Xi'an Wei Fulan peptide Biotechnology Co., Ltd
Keratinocyte growth factor: Xi'an Wei Fulan peptide Biotechnology Co., Ltd
Epidermal growth factor: Xi'an Wei Fulan peptide Biotechnology Co., Ltd
Keratinocyte growth factor: Xi'an Wei Fulan peptide Biotechnology Co., Ltd
Further details of narration is carried out to the present invention with reference to embodiments.
Embodiment 1
A kind of clear acne reparation liquid comprising contain following components by percentage to the quality:
Preparation method:
Step 1: weighing each component by above-mentioned mass percent proportion；
Step 2: house oil is heated to 45 DEG C of thawings, Porcine HGF (keratinocyte growth factor, alkali is then added
Property fibroblast growth factor, epidermal growth factor), after being uniformly dispersed, be rapidly cooled to house oil solidification, obtain cell factor-
House oil lotion；
Step 3: by castor oil, glycerol, propylene glycol, surfactant (glycerin polyether -26, laurel glycol ethers, lauric alcohol
Polyethers -7), deionized water be added in emulsion tank, 85 DEG C are heated to, after emulsifying 30min；Be cooled to 45 DEG C, be added dehydrated alcohol,
Preservative (methylisothiazolinone, sodium benzoate), licorice root extract, dandelion extract, honeysuckle flower extract, scutellariae,radix
Extract, kuh-seng root extract, continue emulsify 10min after, be cooled to≤20 DEG C, then be added the resulting cell of step 2 because
Son-house oil paste, in≤20 DEG C stirring to be uniformly dispersed to get.
Method for preserving: it is saved in refrigerator cold-storage.
Embodiment 2
A kind of clear acne reparation liquid comprising contain following components by percentage to the quality:
Preparation method:
Step 1: weighing each component by above-mentioned mass percent proportion；
Step 2: house oil is heated to 45 DEG C of thawings, Porcine HGF (keratinocyte growth factor, alkali is then added
Property fibroblast growth factor, epidermal growth factor), after being uniformly dispersed, be rapidly cooled to house oil solidification, obtain cell factor-
House oil lotion；
Step 3: by castor oil, glycerol, propylene glycol, surfactant (glycerin polyether -26, laurel glycol ethers, lauric alcohol
Polyethers -7), deionized water be added in emulsion tank, 85 DEG C are heated to, after emulsifying 30min；Be cooled to 45 DEG C, be added dehydrated alcohol,
Preservative (methylisothiazolinone, sodium benzoate), licorice root extract, dandelion extract, honeysuckle flower extract, scutellariae,radix
Extract, kuh-seng root extract, continue emulsify 10min after, be cooled to≤20 DEG C, then be added the resulting cell of step 2 because
Son-house oil paste, in≤20 DEG C stirring to be uniformly dispersed to get.
Method for preserving: with embodiment 1.
Embodiment 3
A kind of clear acne reparation liquid comprising contain following components by percentage to the quality:
Preparation method:
Step 1: weighing each component by above-mentioned mass percent proportion；
Step 2: house oil is heated to 45 DEG C of thawings, Porcine HGF (Keratiocyte growth factor 1 is then added thereto
Son, basic fibroblast growth factor, epidermal growth factor), after being uniformly dispersed, it is rapidly cooled to house oil solidification, obtains cell
The factor-house oil lotion；
Step 3: by castor oil, glycerol, propylene glycol, surfactant (glycerin polyether -26, laurel glycol ethers, lauric alcohol
Polyethers -7), deionized water be added in emulsion tank, 85 DEG C are heated to, after emulsifying 30min；Be cooled to 45 DEG C, be added dehydrated alcohol,
Preservative (methylisothiazolinone, sodium benzoate), licorice root extract, dandelion extract, honeysuckle flower extract, scutellariae,radix
Extract, kuh-seng root extract, continue emulsify 10min after, be cooled to≤20 DEG C, then be added the resulting cell of step 2 because
Son-house oil paste, in≤20 DEG C stirring to be uniformly dispersed to get.
Method for preserving: with embodiment 1.
Comparative example 1
A kind of clear acne reparation liquid comprising contain following components by percentage to the quality:
Preparation method:
Step 1: weighing each component by above-mentioned mass percent proportion；
Step 2: house oil is heated 45 DEG C of thawings, it is rapidly cooled to house oil solidification, obtains house oil lotion；
Step 3: by castor oil, glycerol, propylene glycol, surfactant (glycerin polyether -26, laurel glycol ethers, lauric alcohol
Polyethers -7), deionized water be added in emulsion tank, 85 DEG C are heated to, after emulsifying 30min；Be cooled to 45 DEG C, be added dehydrated alcohol,
Preservative (methylisothiazolinone, sodium benzoate), licorice root extract, dandelion extract, honeysuckle flower extract, scutellariae,radix
Extract, kuh-seng root extract continue after emulsifying 10min, are cooled to≤20 DEG C, house oil lotion is then added, stirs in≤20 DEG C
Mix to be uniformly dispersed to get.
Method for preserving: with embodiment 1.
Comparative example 2
A kind of clear acne reparation liquid comprising contain following components by percentage to the quality:
Preparation method:
Step 1: weighing each component by above-mentioned mass percent proportion；
Step 2: house oil is heated to 45 DEG C of thawings, Porcine HGF (Keratiocyte growth factor 1 is then added thereto
Son, basic fibroblast growth factor, epidermal growth factor), after being uniformly dispersed, it is rapidly cooled to house oil solidification, obtains cell
The factor-house oil lotion；
Step 3: by castor oil, glycerol, propylene glycol, surfactant (glycerin polyether -26, laurel glycol ethers, lauric alcohol
Polyethers -7), deionized water be added in emulsion tank, 85 DEG C are heated to, after emulsifying 30min；Be cooled to 45 DEG C, be added dehydrated alcohol,
Preservative (methylisothiazolinone, sodium benzoate) continues after emulsifying 10min, is cooled to≤20 DEG C, step 2 institute is then added
Cell factor-house oil paste, in≤20 DEG C stirring to be uniformly dispersed to get.
Method for preserving: with embodiment 1.
Comparative example 3
A kind of clear acne reparation liquid comprising contain following components by percentage to the quality:
Preparation method:
Step 1: weighing each component by above-mentioned mass percent proportion；
Step 2: by castor oil, glycerol, propylene glycol, surfactant (glycerin polyether -26, laurel glycol ethers, lauric alcohol
Polyethers -7), deionized water be added in emulsion tank, 85 DEG C are heated to, after emulsifying 30min；Be cooled to 45 DEG C, be added dehydrated alcohol,
Preservative (methylisothiazolinone, sodium benzoate), licorice root extract, dandelion extract, honeysuckle flower extract, scutellariae,radix
Extract, kuh-seng root extract, Porcine HGF (keratinocyte growth factor, basic fibroblast growth factor, epidermis
Growth factor), house oil, continue emulsify 10min after, be cooled to≤20 DEG C to get.
Method for preserving: with embodiment 1.
Effect example 1
Choose the patient that 300 faces have small pox, men and women everybody 150, the age was at 20-30 years old.
The illness of patient is divided into:
Serious: the raw acne time is long, and quantity is more, and red and swollen serious；
Slight: the raw acne time is not grown, and quantity is few, and red and swollen not serious or without redness；
In 300 patients, serious is 150, is slightly 150.
Severe patient and patients with mild are divided into 6 groups respectively, every group of male to female ratio is consistent；
It tests one group: after daily face cleaning, anti-acne skin care item obtained by the embodiment of the present invention 1 being applied to face in right amount, it is early
Evening is each primary；
It tests two groups: after daily face cleaning, anti-acne skin care item obtained by the embodiment of the present invention 2 being applied to face in right amount, it is early
Evening is each primary；
It tests three groups: after daily face cleaning, anti-acne skin care item obtained by the embodiment of the present invention 3 being applied to face in right amount, it is early
Evening is each primary；
It compares one group: after daily face cleaning, anti-acne skin care item obtained by comparative example 1 of the present invention being applied to face in right amount, it is early
Evening is each primary；
It compares two groups: after daily face cleaning, anti-acne skin care item obtained by comparative example 2 of the present invention being applied to face in right amount, it is early
Evening is each primary；
It compares three groups: after daily face cleaning, anti-acne skin care item obtained by comparative example 3 of the present invention being applied to face in right amount, it is early
Evening is each primary；
Wherein severe patient was respectively at the 10th day, the 20th day, the 30th day, the 90th day, the 180th day each primary recovery feelings of statistics
Condition；Patients with mild the results are shown in Table 1 in the 15th day statistics recovery situation.
Therapeutic effect judgment criteria:
Cure completely: whelk 100% is eliminated, and without pockmark, skin is without other adverse reactions；
Basic to cure: whelk 80% is eliminated, and eliminates part without pockmark, and skin is without other adverse reactions；
Be clearly better: whelk 50% is eliminated, and eliminates part without pockmark, and skin is without other adverse reactions.
The SS of therapeutic effect:
Complete cure rate %: the number of cases cured completely ratio shared by its tested group；
Basic cure rate %: the number of cases cured completely and the number of cases summation cured the substantially ratio shared by its tested group
Example；
The rate that is clearly better %: the number of cases cured completely, the number of cases cured substantially and the number of cases summation being clearly better exist
Ratio shared by its tested group.
The recovery situation statistical form of each experimental group of table 1 and control group
From the data in the table, on prescription, liquid is repaired using clear acne obtained by Examples 1 to 3, clear acne is dispelled trace effect
Preferably, it is removed in prescription in the comparative example 1 and prescription of Porcine HGF and removes licorice root extract, dandelion is extracted
The comparative example 2 of object, honeysuckle flower extract, radix scutellariae root extract, kuh-seng root extract, the light trace effect of anti-acne is much not as good as implementation
Example 1~3；Also not as good as use prescription with embodiment 1 only preparation method be different from embodiment 1 comparative example 3.Therefore, it can obtain
Conclusion out: licorice root extract, dandelion extract, honeysuckle flower extract, radix scutellariae root extract, radix sophorae extract in the present invention
Synergistic effect is played in terms of the light trace of anti-acne between object and Porcine HGF, indispensable, these ingredients and others one
A little skin care moisturizing ingredients play effect jointly.
And the prescription of comparative example 3 is same as Example 1, and in preparation method, cell factor is with house oil in comparative example 3
Using independent addition manner, cell factor and house oil are first prepared into cell factor-house oil lotion in embodiment 1, then are added；
Since the freezing point of house oil is 36-43 DEG C, cell factor can be made to be wrapped up by house oil in this way, thus and other
Skin care ingredient isolation, the effective protection activity of cell factor are allowed to persistently effectively, therefore using clear acne made from embodiment 1
Its clear light trace effect of acne of liquid is repaired, is much better than and liquid is repaired using clear acne made from comparative example 3.
Embodiment described above is merely a preferred embodiment of the present invention, and the simultaneously exhaustion of the feasible implementation of non-present invention.It is right
For persons skilled in the art, any aobvious to made by it under the premise of without departing substantially from the principle of the invention and spirit and
The change being clear to should be all contemplated as falling within claims of the invention.
Claims (5)
1. a kind of clear acne repairs liquid, which is characterized in that it includes containing following components by percentage to the quality:
The preparation method that the clear acne repairs liquid specifically comprises the following steps:
Step 1: weighing each component by above-mentioned mass percent proportion；
Step 2: house oil is heated to 40-50 DEG C of thawing, Porcine HGF is then added, after being uniformly dispersed, is rapidly cooled to
House oil solidification, obtains cell factor-house oil lotion；
Step 3: castor oil, glycerol, propylene glycol, surfactant, water are added in emulsion tank, it is emulsified in 80-90 DEG C
30min；After being cooled to 40-50 DEG C, be added ethyl alcohol, preservative, licorice root extract, dandelion extract, honeysuckle flower extract,
Radix scutellariae root extract, kuh-seng root extract, continue after emulsifying 10min, are cooled to≤20 DEG C, and it is resulting thin that step 2 is then added
Intracellular cytokine-house oil paste, in≤20 DEG C stirring to be uniformly dispersed to get.
2. a kind of clear acne according to claim 1 repairs liquid, which is characterized in that it is thin that the Porcine HGF is selected from cutin
The intracellular growth factor, acid fibroblast growth factor, basic fibroblast growth factor, platelet derived growth factor and epidermis
One or more of growth factor；
The surfactant is selected from one or more of glycerin polyether -26, laurel glycol ethers, coceth -7；
The preservative is Phenoxyethanol.
3. a kind of clear acne according to claim 1 repairs liquid, which is characterized in that it includes containing by percentage to the quality
Following components:
4. a kind of clear acne according to claim 1 repairs liquid, which is characterized in that the water is deionized water.
5. a kind of clear acne according to claim 1 repairs liquid, which is characterized in that the ethyl alcohol is dehydrated alcohol.
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| CN105596280A (en) * | 2016-01-19 | 2016-05-25 | 中山百鸥医药科技有限公司 | Acne removal facial cleanser and preparation method thereof |
| CN105816377A (en) * | 2016-04-15 | 2016-08-03 | 冯昱钦 | Wrinkle-free repair cream and preparation method thereof |
| CN105963214A (en) * | 2016-06-29 | 2016-09-28 | 田东县浙缘农业科技有限公司 | Acne-removing and grease-controlling mask lotion and making method thereof |
| CN106727021A (en) * | 2017-01-10 | 2017-05-31 | 广州英姿源生物科技有限公司 | A kind of photon peptide combination preparation for skin repair maintenance and preparation method thereof |
| CN107308049A (en) * | 2017-07-04 | 2017-11-03 | 甘肃青黛中草药美容研究有限责任公司 | A kind of cleansing pox remover print skin care item using traditional Chinese medicinal components as active component |
| CN108686260B (en) * | 2018-05-24 | 2020-02-28 | 海南芬森医疗器械有限公司 | Preparation method of compound scar-proof emulsion biological dressing |
| CN109044860A (en) * | 2018-09-27 | 2018-12-21 | 梅淑婕 | It is a kind of add growth factor skin care compositions and facial mask preparation method |
| CN112515999A (en) * | 2020-12-21 | 2021-03-19 | 阿谷巴(杭州)生物科技发展有限公司 | Mite and acne removing composition rich in cytokines and preparation method thereof |
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