CN102366374A - Naturally extracted anti-acne composition and anti-acne cream prepared thereby - Google Patents

Abstract

The invention relates to a naturally extracted anti-acne composition and anti-acne cream prepared thereby. The invention aims to solve a technical problem about how to provide a naturally extracted anti-acne composition with oil control and acne removal effects as well as anti-acne cream prepared by the composition. The naturally extracted anti-acne composition comprises glycerin, licorice extract, scutellaria extract, honeysuckle extract, sophora flavescens extract and dandelion extract in a weight ratio of 0.1-10: 0.1-10: 0.1-30: 0.1-30: 0.1-10: 0.1-20. The invention also relates to anti-acne cream prepared by the naturally extracted anti-acne composition. Composed of natural extracts, the naturally extracted anti-acne composition of the invention has deoiling and acne removing effects. Added with a common matrix or vector for skin care products, the composition provided in the invention can be prepared into facial masks, facial cleansers or anti-acne cream and other cosmetics. With a good anti-acne effect, the anti-acne cream of the invention is suitable for treating acne and zits by various people groups.

Description

Acne natural extract composition and preparation of the cream eradicates smallpox

Technical field

The invention relates to the field of cosmetics, especially in areas related to acne skin care products, specifically acne is a natural extract composition and preparation of eradicates smallpox cream.

Background technology

At present, a lot of product for resolving poxes are used hormone, antibiotic, and retinoic acid, compositions such as fruit acid, zest is big, causes the drug resistance of skin to Propiobacterium easily, and safety constantly is under suspicion.The product for resolving poxes that lacks the complete pure natural of active component in the prior art.

Summary of the invention

The present invention solves the technical problem is how to fill the gaps existing technology to provide a natural ingredient efficacy raw materials, with the effect of oil and acne acne natural extract composition and preparation of eradicates smallpox cream.

For solving the problems of the technologies described above, anti-acne natural extract compositions of the present invention, its weight is formed as follows:

Glycerol: Radix Glycyrrhizae extract: Radix Scutellariae extracting solution: Flos Lonicerae extractive solution: Radix Sophorae Flavescentis extractive liquid: Herba Taraxaci extract=0.1-10:0.1-10:0.1-30:0.1-30:0.1-10:0.1-20.

The present invention compositions acne natural extracts, natural, environmentally friendly, with oil, eradicates smallpox effect, add commonly used skin care products matrix or carrier, can be made mask, cleanser or acne cream and other cosmetics.

As optimization, the weight ratio of each component is:

Glycerol: Radix Glycyrrhizae extract: Radix Scutellariae extracting solution: Flos Lonicerae extractive solution: Radix Sophorae Flavescentis extractive liquid: Herba Taraxaci extract=0.05:1:3:2:5:5.Facts have proved that the aforementioned proportion effect is best.

Acne eliminating cream of the present invention, hundred parts of compositions of its raw material weight such as following table:

The raw material group	Composition	wt%
			A	Parleam	5
?	Glycerol three (thylhexoic acid) ester	4
			?	Butyrospermum parkii (BUTYROSPERMUM PARKII)	3
?	Cyclomethicone	5
			?	Polydimethylsiloxane	2
?	Glyceryl stearate	2
			?	Cetearyl alcohol	1
?	Caprylic/capric triglyceride	4
			?	PEG-20 methyl glucose sesquistearate	1
?	Methyl glucose sesquistearate	1
			?	Tocopherol acetas	0.5
?	Four-(dibutyl hydroxyl hydrocinnamic acid) pentaerythritol esters	0.02
			?	?	?
B	PPG-2-PEG-11 hydrogenation lauryl alcohol	1
			?	Carbomer	0.5
?	Water	Surplus
			?	Salicylic acid	1
?	Trehalose	1
			?	The EDTA disodium	0.1
?	Triclosan	0.3
			?	?	?
C	Triethanolamine	1
			?	The DMDM hydantoin	0.2
?	?	?
			D	Glycerol	0.05
?	Radix Glycyrrhizae extract	1
			?	The Radix Scutellariae extracting solution	3
?	Flos Lonicerae extractive solution	2
			?	Radix Sophorae Flavescentis extractive liquid	5
?	Herba Taraxaci extract	5

D group raw material constitutes aforementioned anti-acne natural extract compositions, is the acne eliminating cream active component, and all the other are carrier.

Its preparation method comprises the steps:

1.. A is organized raw material, B group raw material be heated to 85 ℃ respectively;

2.. C is organized raw material add B group raw material, stir, form the BC mixed phase;

3.. A is added in the BC mixed phase, stir, form the ABC mixed phase;

4.. after the ABC mixed phase is cooled to 45 ℃, add D group raw material, stir then and be cooled to 36 ℃ and stop to stir discharging, promptly get acne eliminating cream.

The present invention compositions acne natural extracts constituted by the natural extracts, natural, environmentally friendly, with oil, eradicates smallpox effect, add commonly used skin care products matrix or carrier, can be made mask, cleanser or acne cream and other cosmetics, The present invention eradicates eradicates smallpox smallpox frost effect, suitable for all kinds of people treat acne, acne.

The specific embodiment

Embodiment one: get the glycerol of 0.1kg respectively, Radix Glycyrrhizae extract, 6kg Radix Scutellariae extracting solution, 4kg Flos Lonicerae extractive solution, 10kg Radix Sophorae Flavescentis extractive liquid and the 10kg Herba Taraxaci extract of 2kg is mixed into anti-acne natural extract compositions I.

Get the glycerol of 10kg respectively, Radix Glycyrrhizae extract, 30kg Radix Scutellariae extracting solution, 0.1kg Flos Lonicerae extractive solution, 5kg Radix Sophorae Flavescentis extractive liquid and the 0.1 Herba Taraxaci extracting solution of 0.1kg is mixed into anti-acne natural extract compositions II

Get the glycerol of 5kg respectively, Radix Glycyrrhizae extract, 0.1kg Radix Scutellariae extracting solution, 30kg Flos Lonicerae extractive solution, 0.1kg Radix Sophorae Flavescentis extractive liquid and the 20kg Herba Taraxaci extract of 10kg is mixed into anti-acne natural extract compositions III.

Get above-mentioned anti-acne natural extract compositions I, be equipped with suitable quantity of water, process cleansing milk, transfer to 25 moderate patients with acne and use (sooner or later respectively once), after two weeks, 1 people recovery from illness, 6 people have obvious curative effects, and 16 people are effective, and 2 people are invalid.Total effective rate is 88%.

Replace anti-acne natural extract compositions I with anti-acne natural extract compositions II, III respectively, transfer to the moderate patients with acne and use, show curative effect preferably equally, slightly.

Acne eliminating cream of the present invention, hundred parts of compositions of its raw material weight such as following table:

The raw material group	Composition	wt%
			A	Parleam	5
?	Glycerol three (thylhexoic acid) ester	4
			?	Butyrospermum parkii (BUTYROSPERMUM PARKII)	3
?	Cyclomethicone	5
			?	Polydimethylsiloxane	2
?	Glyceryl stearate	2
			?	Cetearyl alcohol	1
?	Caprylic/capric triglyceride	4
			?	PEG-20 methyl glucose sesquistearate	1
?	Methyl glucose sesquistearate	1
			?	Tocopherol acetas	0.5
?	Four-(dibutyl hydroxyl hydrocinnamic acid) pentaerythritol esters	0.02
			?	?	?
B	PPG-2-PEG-11 hydrogenation lauryl alcohol	1
			?	Carbomer	0.5
?	Water	Surplus
			?	Salicylic acid	1
?	Trehalose	1
			?	The EDTA disodium	0.1
?	Triclosan	0.3
			?	?	?
C	Triethanolamine	1
			?	The DMDM hydantoin	0.2
?	?	?
			D	Glycerol	0.05
?	Radix Glycyrrhizae extract	1
			?	The Radix Scutellariae extracting solution	3
?	Flos Lonicerae extractive solution	2
			?	Radix Sophorae Flavescentis extractive liquid	5
?	Herba Taraxaci extract	5

D group raw material constitutes aforementioned anti-acne natural extract compositions, is the acne eliminating cream active component, and all the other are carrier.

Its preparation method comprises the steps:

1.. A is organized raw material, B group raw material be heated to 85 ℃ respectively;

2.. C is organized raw material add B group raw material, stir, form the BC mixed phase;

3.. A is added in the BC mixed phase, stir, form the ABC mixed phase;

4.. after the ABC mixed phase is cooled to 45 ℃, add D group raw material, stir then and be cooled to 36 ℃ and stop to stir discharging, promptly get acne eliminating cream.

This acne eliminating cream effect test:

My one uses clean pox series of products treatment 28 routine light moderate patients with acne from July 31,2011 29 days to 2011 June in, observes through test, obtains certain effect, the result is reported as follows at present:

One, tester's data

Go into group 28 routine acne testers, male's 6 examples, women's 22 examples altogether; Age 16-40 year, average 25.3 years old; Meet the requirements and accomplish clinical observation person's 26 examples, 2 examples withdraw from because of occurring untoward reaction in the process of the test.

Morbidity influence factor: diet: pungent 16 examples, sweet food 9 examples, higher fatty acid 7 examples, irrelevant 8 examples; Relevant person's 10 examples with constipation account for 35.7%; Relevant person's 5 examples with weather account for 17.9%; Relevant person's 12 examples with stress account for 42.9%; Among the women tester with menstruation relative 12 examples, 54.5%.

 

Two, method of testing and effect standard

1. inclusion criteria

With reference to Pill Sburv and international improvement acne staging diagnostic light moderate patients with acne; The men and women does not limit; Be willing to be intended to the regulation that duration of test is observed the drug combination restriction.

2. the method for testing and the course of treatment

(1) method for using: the tester cleans facial back and outside the skin lesion place, is coated with the skim acne eliminating cream, every day each 1 time sooner or later.Not take a shower, shave, sauna bath or strenuous exercise (as causing perspiration) use within 2 hours and 30 minutes afterwards before.

(2) course of treatment: this test is totally 2 weeks, divides and observes scoring for three times, is respectively treatment the 1st day, 1 week of treatment back and treatment closing day, if symptom " eliminations " when treating a week, then external still continues to use extremely and just can stop after 2 weeks altogether.

3. criterion of therapeutical effect

(1) to the scoring of each item sign and pruritus symptom

, treatment the 1st day, treatment 1 all backs and treatment mark for following four signs when finishing: acne, pimple, pustule, seborrhea degree.Each item sign is the scoring of 0-3 level Four.Calculating degree of improvement, formula: scoring * 100% before ［ scoring before the treatment (four sign scoring sums)-treatment back scoring (ditto) ］/treatment.

(2) to the clinical response evaluation

Treatment 1 week back and treated for 2 weeks after change and do an assessment having treated clinical condition since the 1st day respectively.

Clinical recovery: skin lesion disappears basically, and integration reduces >=95%;

Produce effects: residual a small amount of acne, pimple, integration reduces >=70%;

Effectively: skin lesion takes a turn for the better, and integration reduces >=30%

Invalid: do not have and improve, very increase the weight of, integration reduces < 30%

Three, result

The curative effect general comment: cure rate is 3.8%, obvious effective rate is 23.1%, and effective percentage is 57.7%, total effective rate is 84.6%, and inefficiency is 15.4% (seeing table 1).Onset time be 1 day to not waiting in 1 week, average 3 days onset times.

 

Table 1 curative effect general comment table

─────────────────────────────

Follow up a case by regular visits to the % treatment in first week of curative effect and finish to follow up a case by regular visits to %

─────────────────────────────

Fully recover 001 3.8

Produce effects 006 23.1

Effective 11 42.3 15 57.7

Invalid 15 57.7 4 15.4

─────────────────────────────

Add up to 26 100% 26 100%

─────────────────────────────

Acne improvement rate is 41.7% in the clinical disease, pimple, pustule improvement rate 58.6%, and seborrhea degree improvement rate is 31.7% (seeing table 2).The bright and clean pox series of products of above-mentioned tables of data are treated light moderate acne has certain curative effect.

The clinical disease of table 2 is improved situation:

Symptom	Integration before the treatment	Treat all integrations	Treatment back integration	The improvement rate
					Acne	36	30	21	41.7%
Pimple, pustule	87	54	36	58.6%
					The seborrhea degree	41	37	28	31.7%

Four, analyze

1. effect analysis

According to readme effect and testing evaluation evaluation, this product has certain effect to light moderate acne, total effective rate 84.6%.Improve situation analysis from disease: the improvement to face acne and pimple, pustule is comparatively obvious; The improvement rate is respectively 41.7% and 58.6%; Wherein particularly remarkable to the improvement of pimple, pustule; No matter be that significantly the skin lesion effect is better to inflammation for this medicine from test evaluation or from tester oneself feedback; In addition, this medicine also has improvement to a certain degree to facial seborrhea degree, and the improvement rate is 31.7%.

2. safety analysis

Treat viewing duration all testers, have untoward reaction to occur after 2 routine tester's medications and end test, tester's readme is coated with the product rear face and sticky sense of discomfort occurs, initiatively requires to stop to test.Any adverse events does not appear in all the other testers, and hence one can see that, and it is better that this product is treated the safety of light moderate acne.

Claims (3)

1. anti-acne natural extract compositions, its weight is formed as follows:

Glycerol: Radix Glycyrrhizae extract: Radix Scutellariae extracting solution: Flos Lonicerae extractive solution: Radix Sophorae Flavescentis extractive liquid: Herba Taraxaci extract=0.1-10:0.1-10:0.1-30:0.1-30:0.1-10:0.1-20.

2. according to the said anti-acne natural extract of claim 1 compositions, it is characterized in that: the weight ratio of each component is:

Glycerol: Radix Glycyrrhizae extract: Radix Scutellariae extracting solution: Flos Lonicerae extractive solution: Radix Sophorae Flavescentis extractive liquid: Herba Taraxaci extract=0.05:1:3:2:5:5.

3. acne eliminating cream, hundred parts of compositions of its raw material weight such as following table:

The raw material group Composition wt% A Parleam 5 ? Glycerol three (thylhexoic acid) ester 4 ? Butyrospermum parkii (BUTYROSPERMUM PARKII) 3 ? Cyclomethicone 5 ? Polydimethylsiloxane 2 ? Glyceryl stearate 2 ? Cetearyl alcohol 1 ? Caprylic/capric triglyceride 4 ? PEG-20 methyl glucose sesquistearate 1 ? Methyl glucose sesquistearate 1 ? Tocopherol acetas 0.5 ? Four-(dibutyl hydroxyl hydrocinnamic acid) pentaerythritol esters 0.02 ? ? ? B PPG-2-PEG-11 hydrogenation lauryl alcohol 1 ? Carbomer 0.5 ? Water Surplus ? Salicylic acid 1 ? Trehalose 1 ? The EDTA disodium 0.1 ? Triclosan 0.3 ? ? ? C Triethanolamine 1 ? The DMDM hydantoin 0.2 ? ? ? D Glycerol 0.05 ? Radix Glycyrrhizae extract 1 ? The Radix Scutellariae extracting solution 3 ? Flos Lonicerae extractive solution 2 ? Radix Sophorae Flavescentis extractive liquid 5 ? Herba Taraxaci extract 5

D group raw material constitutes the described anti-acne natural extract of claim 2 compositions, is the acne eliminating cream active component, all the other carriers,

Its preparation method comprises the steps:

1.. A is organized raw material, B group raw material be heated to 85 ℃ respectively;

2.. C is organized raw material add B group raw material, stir, form the BC mixed phase;

3.. A is added in the BC mixed phase, stir, form the ABC mixed phase;

4.. after the ABC mixed phase is cooled to 45 ℃, add D group raw material, stir then and be cooled to 36 ℃ and stop to stir discharging, promptly get acne eliminating cream.