CN110179899A - A kind of external application paste preparation and preparation method thereof going acne not trace - Google Patents

A kind of external application paste preparation and preparation method thereof going acne not trace Download PDF

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Publication number
CN110179899A
CN110179899A CN201910319051.3A CN201910319051A CN110179899A CN 110179899 A CN110179899 A CN 110179899A CN 201910319051 A CN201910319051 A CN 201910319051A CN 110179899 A CN110179899 A CN 110179899A
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preparation
external application
acne
kuh
application paste
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周军臣
王庆书
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A61K36/428—Trichosanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/756—Phellodendron, e.g. corktree
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

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Abstract

The invention discloses a kind of external application paste preparations for going acne not trace, the every 100g group of the preparation effective component is grouped as: radix scutellariae 17g, Cortex Phellodendri 15g, kuh-seng 10g, coptis 8g, first nitre files 4.2g, honeysuckle 4g, Radix Angelicae Sinensis 6g, PORIA ALBA 5g, rhizoma typhonii 5g, dandelion 8g, Radix Salviae Miltiorrhizae 2g, radices trichosanthis 3g, root bark of tree peony 7g, menthyl ester 3g, crin thunder element 2.8g, the kuh-seng and Radix Salviae Miltiorrhizae are kuh-seng dry plate and Radix Salviae Miltiorrhizae dry plate respectively, the invention also discloses a kind of preparation methods for removing the acne not external application paste preparation of trace, the following steps are included: raw material mixes, prepare medical fluid, distilling material, launch powder, heating dehydration, filling storage, product sampling observation and cold chain storage.The present invention carries out pulverization process to part Chinese medicine, the utilization rate for being conducive to improve Chinese medicine reduces medicament residual, while by distilling to dandelion and honeysuckle with the dregs of a decoction, facilitate the residual medicament in the recycling dregs of a decoction, while reducing the introducing of partial impurities in dandelion and honeysuckle.

Description

A kind of external application paste preparation and preparation method thereof going acne not trace
Technical field
The present invention relates to nursing materials technical field more particularly to a kind of external application paste preparations and its system for going acne not trace Preparation Method.
Background technique
Acne is a kind of chronic inflammatory skin of pilosebaceous unit, teenager is mainly apt to occur in, to teenager Psychology and social influence it is very big, but tended to after puberty nature mitigate or recovery from illness.Clinical manifestation is to be apt to occur in facial powder With the characteristics of the pleomorphism skin lesion such as thorn, papule, warts, tubercle.Effective component rich in treatment acne in Chinese medicine, is often made into external application Paste preparation.So now proposing a kind of external application paste preparation and preparation method thereof for going acne not trace.
Summary of the invention
Technical problems based on background technology, the invention proposes it is a kind of go acne not the external application paste preparation of trace and Preparation method.
A kind of external application paste preparation going acne not trace proposed by the present invention, the every 100g component of the preparation effective component Composition: radix scutellariae 17g, Cortex Phellodendri 15g, kuh-seng 10g, coptis 8g, first nitre file 4.2g, honeysuckle 4g, Radix Angelicae Sinensis 6g, PORIA ALBA 5g, white attached Sub- 5g, dandelion 8g, Radix Salviae Miltiorrhizae 2g, radices trichosanthis 3g, root bark of tree peony 7g, menthyl ester 3g, crin thunder element 2.8g, the kuh-seng and Radix Salviae Miltiorrhizae difference It is kuh-seng dry plate and Radix Salviae Miltiorrhizae dry plate.
A kind of preparation method for removing the acne not external application paste preparation of trace proposed by the present invention, comprising the following steps:
S1: raw material mixing, radix scutellariae, Cortex Phellodendri, kuh-seng, the coptis, PORIA ALBA, rhizoma typhonii and Radix Salviae Miltiorrhizae put into broken wall according to the proportion In machine, wall-broken grinder revolving speed is 8000R/min, obtains powders A；
S2: preparing medical fluid, and powders A and pure water are mixed with mass ratio for the ratio of 1:5, and launches into refinement kettle, It heats up, makes its boiling, then continuous heat preservation 1-2 hours, are filtered medical fluid, obtain medical liquid B and dregs of a decoction C；
S3: distilling material proportionally puts into dandelion and honeysuckle in distilling apparatus, dregs of a decoction C is covered top, so After distilled, and to fraction liquid carry out rectifying, obtain concentrate D；
S4: launching powder, and concentrate D and medical liquid B are launched into mixing kettle, mixing is stirred, by metronidazole, smallpox Powder, menthyl ester and crin thunder element are proportionally launched in mixing kettle, are stirred mixing, are obtained confection E；
S5: heating dehydration heats up to confection E, obtains final medicament F；
S6: filling storage carries out final medicament F by bottle placer filling；
S7: product sampling observation inspects the product of different batches by random samples, detects active constituent content and aflatoxins etc. Bacterial content:
S8: the qualified product of sampling observation is carried out cold chain storage by cold chain storage.
Preferably, in the S4, concentrate D and medical liquid B dispensing are warming up to 55-68 DEG C into mixing kettle.
Preferably, in the S5, so that moisture evaporates, the water content for controlling final medicament F is 45%-60% for heating.
Preferably, in the S7, detection active constituent content is greater than 30%, and aflatoxins content is less than 0.2%, streptococcus Content is less than 0.01%, and E. CoIi content is less than 0.01%.
Preferably, in the S7, it is isolated to underproof batch products are detected, harmless treatment is carried out to medicament.
Having the beneficial effect that in the present invention
1. being conducive to the utilization rate for improving Chinese medicine by carrying out pulverization process to part Chinese medicine, medicament residual is reduced, simultaneously By distilling to dandelion and honeysuckle with the dregs of a decoction, facilitate the residual medicament in the recycling dregs of a decoction, at the same reduce dandelion and The introducing of partial impurities in honeysuckle.
2. the stability of western medicine composition is effectively guaranteed by being allocated mixing to medicament, long-time high temperature is avoided Caused by drug effect decompose, be conducive to improve drug effect.
Detailed description of the invention
Fig. 1 be it is proposed by the present invention it is a kind of go acne not external application paste preparation of trace and preparation method thereof process signal Figure.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.
Referring to Fig.1, a kind of external application paste preparation going acne not trace, the every 100g group of preparation effective component be grouped as: it is yellow Siberian cocklebur 17g, Cortex Phellodendri 15g, kuh-seng 10g, coptis 8g, first nitre file 4.2g, honeysuckle 4g, Radix Angelicae Sinensis 6g, PORIA ALBA 5g, rhizoma typhonii 5g, Pu Public English 8g, Radix Salviae Miltiorrhizae 2g, radices trichosanthis 3g, root bark of tree peony 7g, menthyl ester 3g, crin thunder element 2.8g, kuh-seng and Radix Salviae Miltiorrhizae are kuh-seng dry plate respectively With Radix Salviae Miltiorrhizae dry plate.
A kind of preparation method for removing the acne not external application paste preparation of trace, comprising the following steps:
S1: raw material mixing, radix scutellariae, Cortex Phellodendri, kuh-seng, the coptis, PORIA ALBA, rhizoma typhonii and Radix Salviae Miltiorrhizae put into broken wall according to the proportion In machine, wall-broken grinder revolving speed is 8000R/min, obtains powders A；
S2: preparing medical fluid, and powders A and pure water are mixed with mass ratio for the ratio of 1:5, and launches into refinement kettle, It heats up, makes its boiling, then continuous heat preservation 1-2 hours, are filtered medical fluid, obtain medical liquid B and dregs of a decoction C；
S3: distilling material proportionally puts into dandelion and honeysuckle in distilling apparatus, dregs of a decoction C is covered top, so After distilled, and to fraction liquid carry out rectifying, obtain concentrate D；
S4: launching powder, and concentrate D and medical liquid B are launched into mixing kettle, mixing is stirred, by metronidazole, smallpox Powder, menthyl ester and crin thunder element are proportionally launched in mixing kettle, are stirred mixing, are obtained confection E；
S5: heating dehydration heats up to confection E, obtains final medicament F；
S6: filling storage carries out final medicament F by bottle placer filling；
S7: product sampling observation inspects the product of different batches by random samples, detects active constituent content and aflatoxins etc. Bacterial content:
S8: the qualified product of sampling observation is carried out cold chain storage by cold chain storage.
In S4, concentrate D and medical liquid B dispensing are warming up to 55-68 DEG C into mixing kettle, in S5, heating is so that moisture steams Hair controls the water content of final medicament F as 45%-60%, and in S7, detection active constituent content is greater than 30%, and aflatoxins contains Amount is less than 0.2%, and hammer bacterial content is less than 0.01%, and E. CoIi content is less than in 0.01%, S7, to underproof batch of detection Secondary product is isolated, and carries out harmless treatment to medicament.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto, Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.

Claims (7)

1. a kind of external application paste preparation for going acne not trace, which is characterized in that the every 100g group grouping of the preparation effective component At: radix scutellariae 17g, Cortex Phellodendri 15g, kuh-seng 10g, coptis 8g, first nitre file 4.2g, honeysuckle 4g, Radix Angelicae Sinensis 6g, PORIA ALBA 5g, rhizoma typhonii 5g, dandelion 8g, Radix Salviae Miltiorrhizae 2g, radices trichosanthis 3g, root bark of tree peony 7g, menthyl ester 3g, crin thunder element 2.8g.
2. a kind of external application paste preparation for going acne not trace according to claim 1, which is characterized in that the kuh-seng and pellet Ginseng is kuh-seng dry plate and Radix Salviae Miltiorrhizae dry plate respectively.
3. a kind of preparation method for removing the acne not external application paste preparation of trace according to claim 1, which is characterized in that packet Include following steps:
S1: raw material mixing, radix scutellariae, Cortex Phellodendri, kuh-seng, the coptis, PORIA ALBA, rhizoma typhonii and Radix Salviae Miltiorrhizae put into wall-breaking machine according to the proportion In, wall-broken grinder revolving speed is 8000R/min, obtains powders A；
S2: preparing medical fluid, and powders A and pure water are mixed with mass ratio for the ratio of 1:5, and launches to refining in kettle, carried out Heating, makes its boiling, and then continuous heat preservation 1-2 hours, are filtered medical fluid, obtain medical liquid B and dregs of a decoction C；
S3: distilling material proportionally puts into dandelion and honeysuckle in distilling apparatus, by dregs of a decoction C cover top, then into Row distillation, and rectifying is carried out to fraction liquid, obtain concentrate D；
S4: launching powder, and concentrate D and medical liquid B are launched into mixing kettle, mixing is stirred, by metronidazole, radices trichosanthis, Menthyl ester and crin thunder element are proportionally launched in mixing kettle, are stirred mixing, are obtained confection E；
S5: heating dehydration heats up to confection E, obtains final medicament F；
S6: filling storage carries out final medicament F by bottle placer filling；
S7: product sampling observation inspects the product of different batches by random samples, detects the bacteriums such as active constituent content and aflatoxins Content:
S8: the qualified product of sampling observation is carried out cold chain storage by cold chain storage.
4. a kind of preparation method for removing the acne not external application paste preparation of trace according to claim 1, which is characterized in that institute It states in S4, concentrate D and medical liquid B dispensing is warming up to 55-68 DEG C into mixing kettle.
5. a kind of preparation method for removing the acne not external application paste preparation of trace according to claim 1, which is characterized in that institute It states in S5, so that moisture evaporates, the water content for controlling final medicament F is 45%-60% for heating.
6. a kind of preparation method for removing the acne not external application paste preparation of trace according to claim 1, which is characterized in that institute It states in S7, detection active constituent content is greater than 30%, and aflatoxins content is less than 0.2%, and hammer bacterial content is less than 0.01%, greatly Enterobacteria content is less than 0.01%.
7. a kind of preparation method for removing the acne not external application paste preparation of trace according to claim 1, which is characterized in that institute It states in S7, is isolated to underproof batch products are detected, harmless treatment is carried out to medicament.
CN201910319051.3A 2019-04-19 2019-04-19 A kind of external application paste preparation and preparation method thereof going acne not trace Pending CN110179899A (en)

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Citations (2)

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CN102366374A (en) * 2011-11-10 2012-03-07 珠海姗拉娜化妆品有限公司 Naturally extracted anti-acne composition and anti-acne cream prepared thereby
CN103933179A (en) * 2013-01-23 2014-07-23 王思农 A medicine used for treating acne and a preparing method thereof

Patent Citations (2)

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Application publication date: 20190830