CN106473944B - A kind of acne-removing composition and acne eliminating cream containing antibacterial peptide - Google Patents
A kind of acne-removing composition and acne eliminating cream containing antibacterial peptide Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The present invention provides a kind of acne-removing composition containing antibacterial peptide, including following component and its mass fraction: 5~20 parts of Gotu Kola P.E, 1~10 part of liquiritin and 0.5~3 part of antibacterial peptide.The invention belongs to cosmetic technical fields, acne-removing composition provided by the invention by compounding antibacterial peptide with Gotu Kola P.E and liquiritin in certain proportion, synergy may be implemented, 90% or more is reached to the bacteriostasis rate of whelk relevant bacteria species, there is significant control efficiency to whelk, safety is good, reduces the use concentration of antibacterial peptide.
Description
Technical field
The invention belongs to cosmetic technical field more particularly to a kind of acne-removing compositions and acne eliminating cream containing antibacterial peptide.
Background technique
Whelk is a kind of chronic inflammatory skin of pilosebaceous follicle, is dermatology common disease, is mainly in face, neck
The sebaceous glands such as portion, shirtfront back position abundant, is common in the youth of both sexes of adolescence, and Chinese medicine claims " acne ", and doctor trained in Western medicine claims
For " acne ".When puberty, intracorporal hormone can stimulate hair growth, promote smegma more many greases of sauce, hair and skin
Therefore adipose gland accumulates many substances, adhere to grease and bacterium, causes the reaction such as red swelling of the skin.According to statistics, 80% or more blueness
Year, men and women occurred different degrees of whelk in puberty, caused great puzzlement to youth of both sexes.
Modern medicine is thought: whelk is multifactor functioning as a result, the growth of whelk usually requires to meet such as
Lower condition: 1. hair follicle keratinization is hyperfunction, clogging of pores；2. endotheliosis, sebum secretion is vigorous；3. the growth of bacterium.It is present in
There are many bacterial species in pilosebaceous follicle, including Pseudomonas aeruginosa, Candida albicans and propionibacterium acnes etc., wherein acne third
Acidfast bacilli is the main bacterium for causing whelk, belongs to typical gram-positive anaerobic bacterium.Propionibacterium acnes metabolism generates
Fatty acid can stimulate skin and promote sebaceous glands excessive secretion, to make sebum drainage difficulty, eventually lead to inflammatory papules,
The generation of acne and useless fellow, and then cause hair follicle inflammation, skin injury and form scar.
Acne-eliminating cosmetic currently on the market is many kinds of, and there are the cosmetics of prevention and treatment acne effect to have cream, frost, lotion etc.
Dosage form, common active constituent have salicylic acid, phenol, camphor, VitAVitE, chlorophyll, estrogen, retinol palm fibre
Glycerin monostearate, urea capsule, plant extracts, antibiotic etc..With the raising that security performance requires, antibiotic and hormonal substance exist
It is disabled or limit the use of in acne-eliminating cosmetic.
It includes ox that Chinese patent application CN 105012479, which discloses a kind of acne-removing composition and Whelk-eliminating paste, acne-removing composition,
Oily fruit tree fruit rouge, phellodendron extract, black extract of willow bark, purslane extract, extractive of perilla, Gotu Kola P.E and green
Beans extract achieves preferable anti-acne effect by the collective effect of a variety of extracts, but the component of active constituent is more complex.
Chinese patent application CN 105411873 disclose antibacterial peptide as anti-inflammatory acne removing agent cosmetics preparation in answering
With, using antibacterial peptide as single active ingredient, the concentration of antibacterial peptide liquid can be effectively suppressed when being 3.0% propionibacterium acnes and
The growth of Staphylococcus aureus, it is more demanding to the concentration of antibacterial peptide.
Therefore it provides a kind of anti-acne active constituent is simpler, antibacterial peptide concentration is lower, realizes synergistic anti-acne combination
Object and its cosmetics are of great significance.
Summary of the invention
To solve problems of the prior art, inventor provides a kind of acne-removing composition containing antibacterial peptide, pass through by
Antibacterial peptide compounds in certain proportion with Gotu Kola P.E and liquiritin, and synergy may be implemented, to whelk correlation bacterium
The bacteriostasis rate of kind reaches 90% or more, has significant control efficiency to whelk, safety is good, reduces making for antibacterial peptide
Use concentration.Based on above-mentioned discovery, thereby completing the present invention.
The purpose of the present invention will be further described in detail below reflect and description.
The present invention provides a kind of acne-removing composition containing antibacterial peptide, including following component and its mass fraction: centella mentions
Take 5~20 parts of object, 1~10 part of liquiritin and 0.5~3 part of antibacterial peptide.
In above-mentioned composition, antibacterial peptide is a kind of biologically active Small-molecule basic generated in organism through induction
Polypeptide is made of 20~60 amino acid residues, and molecular weight has broad spectrum antibiotic activity, to a variety of 2000~7000 or so
Bacterium has stronger killing effect；Gotu Kola P.E have effects that it is anti-inflammatory, dispel aging cutin, can effectively dissolve pore
The grease soils of depths, dredge blockage hair follicle improve skin quality conducive to the discharge of toxin；Liquiritin energy conditioning skin, antiallergy,
Activating cell plays the role of enhancing other active components effect.By adopting the above technical scheme, by Gotu Kola P.E, sweet
The synergy of careless glycosides and antibacterial peptide, dispelled from sterilization, the control of anti-inflammatory, grease, aging cutin, skin condition etc. realize it is comprehensive
Prevention and treatment is closed, 90% or more is reached to the bacteriostasis rate of whelk relevant bacteria species, there is significant control efficiency, safety to whelk
Property is good, reduces the use concentration of antibacterial peptide.
Preferably, the acne-removing composition containing antibacterial peptide, including following component and its mass fraction: centella is extracted
10~15 parts of object, 3~8 parts of liquiritin and 1~3 part of antibacterial peptide.
It is highly preferred that the acne-removing composition containing antibacterial peptide, including following component and its mass fraction: centella mentions
Take 12 parts of object, 6 parts of liquiritin and 2 parts of antibacterial peptide.
Preferably, the antibacterial peptide is selected from house fly antibiotic peptide or antibacterial peptide DC.Antibacterial peptide DC can refer to patent
200510032743.8 method in is prepared, and the activity of antibacterial peptide DC is 5000IU/mL.
In addition, the present invention also provides a kind of acne eliminating cream, including following component and its parts by weight: the acne-removing composition
6~12 parts, 2~4 parts of saualane, 1~3 part of wheat-germ oil, 1~3 part of cetearyl glucoside, isopropyl myristate 1
~3 parts, 1~3 part of ethylhexyl palmitate, 1~2 part of octyl methoxycinnamate, 3~5 parts of glycerol, 0.5~2 part of xanthan gum,
0.5~2 part of cetostearyl alcohol, 2~6 parts of sorbierite, 2~6 parts of propylene glycol and 60~80 parts of water.
Preferably, the acne eliminating cream, including following component and its parts by weight: 10 parts of the acne-removing composition, angle
3 parts of shark alkane, 2 parts of wheat-germ oil, 2 parts of cetearyl glucoside, 2 parts of isopropyl myristate, ethylhexyl palmitate 1
Part, 1 part of octyl methoxycinnamate, 4 parts of glycerol, 1 part of xanthan gum, 2 parts of cetostearyl alcohol, 3 parts of sorbierite, 3 parts of propylene glycol and
66 parts of water.
Preferably, the acne eliminating cream further includes 0.1~1 part of essence and/or 0.1~1 part of chelating agent.
Correspondingly, the present invention also provides the preparation method of acne eliminating cream, include the following steps:
S1 weigh saualane, wheat-germ oil, cetearyl glucoside, isopropyl myristate, palm acid ethyl oneself
Ester, octyl methoxycinnamate and cetostearyl alcohol are stirred and heated to 80~85 DEG C, obtain material A in first reactor,
It keeps the temperature spare；
S2 weighs glycerol, sorbierite, propylene glycol, xanthan gum and water in second reactor, is stirred and heated to 80~85
DEG C, it is slowly added to the material flow A, homogeneous is stirred, obtains material B；It is preferred that 5~10min of homogeneous.
The material B is cooled to 40~45 DEG C by S3, is weighed and is added the acne-removing composition, stir evenly, cooling,
Obtain acne eliminating cream.
Compared with prior art, the beneficial effects of the present invention are: the acne-removing composition provided by the invention containing antibacterial peptide is logical
The synergy for crossing Gotu Kola P.E, liquiritin and antibacterial peptide is dispelled, skin from sterilization, anti-inflammatory, grease control, aging cutin
Integrated control is realized in skin conditioning etc., reaches 90% or more to the bacteriostasis rate of whelk relevant bacteria species, has to whelk
Significant control efficiency, safety is good, reduces the use concentration of antibacterial peptide.Whelk-eliminating paste provided by the invention can significantly reduce skin
Skin fat content promotes the quick absorption of active constituent, prevents the symptoms such as the blocking of pore, and safety is good, and quality is stablized, room
Temperature still has significant fungistatic effect to whelk relevant bacteria species after saving 2 years.
Specific embodiment
Below by specific embodiment, the present invention is described in further detail.
In the present invention, related component and raw material are conventional commercial product, or can pass through the ordinary skill in the art
Means obtain, such as: Gotu Kola P.E is purchased from Guilin Laiyin Biotechnology Co., Ltd., and No. CAS is 84696-21-9.
Acne-removing composition of the embodiment one containing antibacterial peptide
Acne-removing composition containing antibacterial peptide includes following component and its mass fraction: 12 parts of Gotu Kola P.E, liquiritin 6
Part and 2 parts of antibacterial peptide DC.
Preparation method: weighing Gotu Kola P.E, liquiritin and antibacterial peptide DC, mixes, obtains the anti-acne group containing antibacterial peptide
Close object.
Acne-removing composition of the embodiment two containing antibacterial peptide
Acne-removing composition containing antibacterial peptide includes following component and its mass fraction: 15 parts of Gotu Kola P.E, liquiritin 8
Part and 3 parts of house fly antibiotic peptide.
Preparation method is the same as embodiment one.
Acne-removing composition of the embodiment three containing antibacterial peptide
Acne-removing composition containing antibacterial peptide includes following component and its mass fraction: 10 parts of Gotu Kola P.E, liquiritin 3
Part and 1 part of antibacterial peptide DC.
Preparation method is the same as embodiment one.
Comparative example 1
Acne-removing composition includes following component and its mass fraction: 18 parts and 2 parts of antibacterial peptide DC of Gotu Kola P.E.
Preparation method is the same as embodiment one.
Comparative example 1 and the difference of embodiment one are: being free of liquiritin, the number of Gotu Kola P.E increases.
Comparative example 2
Acne-removing composition includes following component and its mass fraction: 18 parts and 2 parts of antibacterial peptide DC of liquiritin.
Preparation method is the same as embodiment one.
Comparative example 2 and the difference of embodiment one are: being free of Gotu Kola P.E, the number of liquiritin increases.
Comparative example 3
Acne-removing composition includes following component and its mass fraction: 12 parts of Gotu Kola P.E, 8 parts of liquiritin.
Preparation method is the same as embodiment one.
Comparative example 3 and the difference of embodiment one are: being free of antibacterial peptide DC, the number of liquiritin increases.
Example IV Whelk-eliminating paste
Acne eliminating cream includes following component and its parts by weight: 10 parts of the acne-removing composition of embodiment one, 3 parts of saualane, small
2 parts of wheat germ oil, 2 parts of cetearyl glucoside, 2 parts of isopropyl myristate, 1 part of ethylhexyl palmitate, methoxyl group meat
1 part of cinnamate, 4 parts of glycerol, 1 part of xanthan gum, 2 parts of cetostearyl alcohol, 3 parts of sorbierite, 3 parts of propylene glycol and 66 parts of water.
The preparation method of acne eliminating cream includes the following steps:
S1 weigh saualane, wheat-germ oil, cetearyl glucoside, isopropyl myristate, palm acid ethyl oneself
Ester, octyl methoxycinnamate and cetostearyl alcohol are stirred and heated to 82 DEG C in first reactor, obtain material A, heat preservation
It is spare；
S2 weighs glycerol, sorbierite, propylene glycol, xanthan gum and water in second reactor, is stirred and heated to 82 DEG C, delays
Slowly the material flow A is added, stirs homogeneous 5min, obtains material B；
The material B is cooled to 42 DEG C by S3, is weighed and is added the acne-removing composition of embodiment one, stir evenly, cooling,
Obtain acne eliminating cream.
Comparative example 4
Acne eliminating cream includes following component and its parts by weight: 10 parts of the acne-removing composition of comparative example 1,3 parts of saualane, wheat
2 parts of embryo oil, 2 parts of cetearyl glucoside, 2 parts of isopropyl myristate, 1 part of ethylhexyl palmitate, methoxycinnamate
1 part of misery ester, 4 parts of glycerol, 1 part of xanthan gum, 2 parts of cetostearyl alcohol, 3 parts of sorbierite, 3 parts of propylene glycol and 66 parts of water.
The same example IV of the preparation method of acne eliminating cream.
Comparative example 5
Acne eliminating cream includes following component and its parts by weight: 10 parts of the acne-removing composition of comparative example 2,3 parts of saualane, wheat
2 parts of embryo oil, 2 parts of cetearyl glucoside, 2 parts of isopropyl myristate, 1 part of ethylhexyl palmitate, methoxycinnamate
1 part of misery ester, 4 parts of glycerol, 1 part of xanthan gum, 2 parts of cetostearyl alcohol, 3 parts of sorbierite, 3 parts of propylene glycol and 66 parts of water.
The same example IV of the preparation method of acne eliminating cream.
Comparative example 6
Acne eliminating cream includes following component and its parts by weight: 10 parts of the acne-removing composition of comparative example 3,3 parts of saualane, wheat
2 parts of embryo oil, 2 parts of cetearyl glucoside, 2 parts of isopropyl myristate, 1 part of ethylhexyl palmitate, methoxycinnamate
1 part of misery ester, 4 parts of glycerol, 1 part of xanthan gum, 2 parts of cetostearyl alcohol, 3 parts of sorbierite, 3 parts of propylene glycol and 66 parts of water.
The same example IV of the preparation method of acne eliminating cream.
One safety testing of test example
The related request of " human skin patch " in 2015 editions " cosmetics health specifications " issued referring to the Ministry of Public Health
Tested with acne eliminating cream of the measuring method to the embodiment of the present invention four, comparative example 4 to comparative example 6, respectively 0h, 6h, 12h,
For 24 hours, 48h observes dermoreaction, and the experimental result of all trial volunteers is negative findings, does not occur skin adverse reaction.
Acne eliminating cream provided by the invention is nonirritant, and safety is good.
Two bacteriostatic test of test example
Referring to appendix C 4 in GB 15979-2002 " Disposable Sanitary Accessory sanitary standard ", " stripping property resists (suppression) bacterium
The bacteriostasis property that product bacteriostasis property test method " carries out the acne eliminating cream of the embodiment of the present invention four, comparative example 4 to comparative example 6 is surveyed
Fixed: the 1. preparation of bacteria suspension: test organisms for 24 hours washed down with 0.03mol/L phosphate buffer by (bacterium) culture, is made
106efu/mL bacteria suspension；2. being taken respectively by test agent 1g, adds the above-mentioned bacteria suspension 0.1mL even spread mixing of people, start timing
After 20min, 9mL 0.03mol/L phosphate buffer is added and mixes well, after making appropriate dilution, takes wherein 3 dilutions, point
It does not take 1mL to be placed in two parallel plates and adds corresponding culture medium difference Hybrid NC machine tool, make bacterium colony counting.The above test weight
It is 3 times multiple, its average is taken, while setting blank control.Calculation formula: X (%)=(A-B)/A × 100, wherein X is bacteriostasis rate, A
Clump count is averagely recycled for control sample；B is that test specimen averagely recycles clump count.
Acne-removing evaluation criterion is as shown in table 1, and the bacteriostasis efficacy evaluation of different acne eliminating creams is as shown in table 2.
1 acne-removing evaluation criterion of table
The bacteriostasis efficacy evaluation table of 2 acne eliminating cream of table
As known from Table 2, the acne eliminating cream of the embodiment of the present invention four all has very strong bactericidal to whelk relevant bacteria species
Effect, acne-removing are evaluated as effective；And 4 groups of comparative example and 5 groups of comparative example are in the feelings for lacking liquiritin or Gotu Kola P.E
Under condition, acne-removing is evaluated as effectively, 6 groups of comparative example in the case where lacking antibacterial peptide, bactericidal and bacteriostatic effect significantly reduce, dispel
Acne efficacy assessments are invalid.Make as it can be seen that Gotu Kola P.E, liquiritin and antibacterial peptide play synergistic bactericidal
With.
Three stability test of test example
Accelerated stability test is carried out to the acne eliminating cream of the embodiment of the present invention four, comparative example 4 to comparative example 6, comprising: heat-resisting
Test, is placed 1 month in 45 DEG C of insulating box, and whether observation sample is layered, changes colour, goes bad；Low temperature resistant test, at -10 DEG C
It is placed 1 month in insulating box, whether observation sample is layered, changes colour, goes bad.The results are shown in Table 3.
The accelerated stability test result of the different acne eliminating creams of table 3
| Group | Heat resistant test | Low temperature resistant test |
| Example IV group | It is not layered, do not change colour, do not go bad | It is not layered, do not change colour, do not go bad |
| 4 groups of comparative example | Layering does not change colour, goes bad | It is not layered, do not change colour, do not go bad |
| 5 groups of comparative example | It is not layered, do not change colour, do not go bad | It is not layered, do not change colour, do not go bad |
| 6 groups of comparative example | It is not layered, do not change colour, do not go bad | It is not layered, do not change colour, do not go bad |
As known from Table 3, the stability of acne eliminating cream provided by the invention is good, and 4 groups of comparative example is the case where being free of liquiritin
Under, occur being layered through heat resistant test and denaturalization phenomenon, illustrates that liquiritin plays an important role to the stability of system of the present invention.
In addition, not being layered yet after example IV group is stored at room temperature 2 years, not changing colour, do not go bad, bacteriostasis efficacy is carried out
Detection, the results are shown in Table 4.As known from Table 4, after the acne eliminating cream of example IV saves 2 years, remain to that there is very strong bactericidal
Effect, stability is good, and acne-removing is evaluated as effective.
Bacteriostasis efficacy evaluation table behind acne eliminating cream preservation 1 year and 2 years of 4 example IV of table
The clinical test of four acne eliminating cream of test example
The acne eliminating cream of the acne eliminating cream of example IV and certain commercially available famous brand name is subjected to the on probation of whelk patient volunteer,
It takes and is coated in clean affected part in right amount, 2 times a day, try out 4 weeks.In whelk patient volunteer, 64 people of female, male 56 people, the age
Between 20~30 years old, face has apparent acne and small pox, and skin characteristic is Oily, and no skin disease allergies meet
Subject volunteers inclusion criteria, is randomly divided into 2 groups, every group of 60 people (32 people of female, male 28 people), and the difference between 2 groups does not have system
Meter learns meaning.It is tested and is visited using the skin oil and fat content Sebumeter of German Courage Khazaka company (German CK company)
Head is detected, and patient volunteer was in the 0th day, the 14th day, the content of the 28th day skin oil and fat, and the results are shown in Table 5, simultaneously
Collect patient volunteer using after 28 days anti-acne, acne print desalination and in terms of evaluation marking, each is expired
It is divided into 10 points, the results are shown in Table 6.
5 patient volunteer of table tries out the content of the skin oil and fat of different time
6 patient volunteer of table tries out the evaluation marking of acne eliminating cream of the present invention
As known from Table 5, fat content can be significantly reduced after acne eliminating cream use provided by the invention, uses the grease after 28 days
Content reduces up to 59.4%, better than the 53.7% of commercially available control group.
As known from Table 6, acne eliminating cream provided by the invention is all tried out in terms of anti-acne, acne print desalination and pore
The approval of person, in addition to suitable with commercially available control group at anti-inflammatory aspect of releiving, in anti-acne, acne print desalination, pore is shunk and skin oil
Light reduces aspect and is all substantially better than commercially available control group.There are the diseases such as pruitus, shouting pain in whole non-someone of patient volunteer
Shape illustrates that acne eliminating cream provided by the invention has good anti-acne effect, and safety is good.
The above content is a further detailed description of the present invention in conjunction with specific preferred embodiments, and it cannot be said that
Specific implementation of the invention is only limited to these instructions.For those of ordinary skill in the art to which the present invention belongs, exist
Under the premise of not departing from present inventive concept, a number of simple deductions or replacements can also be made, all shall be regarded as belonging to of the invention
Protection scope.
Claims (8)
1. a kind of acne-removing composition containing antibacterial peptide, it is characterised in that: be made of following component and its mass fraction: centella mentions
Take 5 ~ 20 parts of object, 1 ~ 10 part and 0.5 ~ 3 part of antibacterial peptide of liquiritin.
2. the acne-removing composition according to claim 1 containing antibacterial peptide, it is characterised in that: by following component and its mass parts
Array is at 3 ~ 8 parts and 1 ~ 3 part of antibacterial peptide of: 10 ~ 15 parts of Gotu Kola P.E, liquiritin.
3. the acne-removing composition according to claim 2 containing antibacterial peptide, it is characterised in that: by following component and its mass parts
Array is at 12 parts of Gotu Kola P.E, 6 parts of liquiritin and 2 parts of antibacterial peptide.
4. the acne-removing composition according to any one of claim 1 to 3 containing antibacterial peptide, it is characterised in that: the antibacterial
Peptide is selected from house fly antibiotic peptide or antibacterial peptide DC.
5. a kind of acne eliminating cream, it is characterised in that: including following component and its parts by weight: described in any one of claims 1 to 4
6 ~ 12 parts of acne-removing composition, 2 ~ 4 parts of saualane, 1 ~ 3 part of wheat-germ oil, 1 ~ 3 part of cetearyl glucoside, nutmeg
1 ~ 3 part of isopropyl propionate, 1 ~ 3 part of ethylhexyl palmitate, 1 ~ 2 part of octyl methoxycinnamate, 3 ~ 5 parts of glycerol, xanthan gum 0.5 ~ 2
Part, 0.5 ~ 2 part of cetostearyl alcohol, 2 ~ 6 parts of sorbierite, 2 ~ 6 parts and 60 ~ 80 parts of water of propylene glycol.
6. acne eliminating cream according to claim 5, it is characterised in that: including following component and its parts by weight: claim 1
To 10 parts of acne-removing composition described in any one of 4,3 parts of saualane, 2 parts of wheat-germ oil, 2 parts of cetearyl glucoside,
2 parts of isopropyl myristate, 1 part of ethylhexyl palmitate, 1 part of octyl methoxycinnamate, 4 parts of glycerol, 1 part of xanthan gum, whale
2 parts of wax stearyl alcohol, 3 parts of sorbierite, 3 parts of propylene glycol and 66 parts of water.
7. acne eliminating cream according to claim 5 or 6, it is characterised in that: further include 0.1 ~ 1 part of essence and/or chelating agent
0.1 ~ 1 part.
8. the preparation method of acne eliminating cream according to claim 5, characterized by the following steps:
S1 weigh saualane, wheat-germ oil, cetearyl glucoside, isopropyl myristate, ethylhexyl palmitate,
Octyl methoxycinnamate and cetostearyl alcohol are stirred and heated to 80 ~ 85 DEG C in first reactor, obtain material A, heat preservation
It is spare；
S2 weighs glycerol, sorbierite, propylene glycol, xanthan gum and water in second reactor, is stirred and heated to 80 ~ 85 DEG C, delays
Slowly the material A is added, stirs homogeneous, obtains material B；
The material B is cooled to 40 ~ 45 DEG C by S3, is weighed and is added the acne-removing composition, stir evenly, cooling, is obtained
Acne eliminating cream.
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| CN108403582A (en) * | 2018-04-08 | 2018-08-17 | 北京皓尔生物科技有限公司 | A kind of anti-acne, acne-removing composition and its application containing antibacterial peptide |
| CN108324586A (en) * | 2018-04-08 | 2018-07-27 | 北京皓尔生物科技有限公司 | A kind of antibacterial anti-inflammatory composition and its application |
| CN110279844A (en) * | 2019-01-31 | 2019-09-27 | 浙江星杭泰乐生物医药有限公司 | Artificial synthetic antimicrobial peptide is preparing application and inhibiting bacteria and diminishing inflammation acne-removing composition in inhibiting bacteria and diminishing inflammation acne-eliminating cosmetic or external medicine preparation |
| CN110507680B (en) * | 2019-09-04 | 2022-08-19 | 广州市半月美医药科技有限公司 | Compound external liniment for treating facial acne and acne rosacea and preparation method thereof |
| CN115487114B (en) * | 2022-10-12 | 2023-10-03 | 广东粤港澳大湾区黄埔材料研究院 | Antibacterial peptide composition, acne-removing cream containing antibacterial peptide composition and preparation method of acne-removing cream |
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| CN106473944A (en) | 2017-03-08 |
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