KR101274811B1 - Potent anti-acne composition containing perilla frutescens and/or lygodium japonicum extract - Google Patents

Abstract

The present invention contains the extract of Perilla frutescens and / or Lygodium japonicum having excellent antimicrobial activity against propionibacterium acnes known as the main cause of acne, thus preventing and treating acne. It relates to an excellent composition.

Acne, leaflet extract, haegeum extract, face wash, soap, cream

Description

Potent anti-acne composition containing perilla frutescens and / or lygodium japonicum extract}

The present invention relates to a composition for the prevention and treatment of acne containing leaflet extract and / or haegeum extract. More specifically, the present invention contains a leaf extract (Perilla frutescens) and / or Lygodium japonicum extract excellent in antimicrobial activity against Propionibacterium acnes known as the main cause of acne onset prevention of acne And to compositions having excellent therapeutic effects.

In general, acne is a disease mainly caused in adolescence, adolescence, during which a large amount of androgen hormones are present in the blood. Testosterone, one of the male hormones, is converted to dihydrotestosterone by 5 alpha-reductase, which is the main cause of sebum production in the sebocytes of sebaceous gland. Acts as a substance to promote sebum production. This mechanism leads to the formation of primary micro-comedones due to the overproduction of sebum, secretion and hyperkeratosis of the pores, and chronicity caused by propionibacterium acnes, an anaerobic skin flora that exists in the sebum of the pores. Inflammatory diseases (papule), pustules (pustule), cysts (cyst), nodules (nodule) develops and, if severe, scars (scar).

Looking at the main efficacy and side effects of the current treatment for the treatment of acne, Retinoic acid, a vitamin-A derivative, is mainly used to exfoliate pores, but the stratum of skin It has been reported to cause damage to normal cells of corneum and cause skin redness, and benzoyl peroxide preparations have been reported to reduce free fatty acids in pores by exerting strong antibacterial action as well as exfoliating skin. It has been reported to cause skin sensitization (contact dermatitis, erythema, dry skin, exfoliation) in some patients. In addition, the most widely used salicylic acid preparations or sulfur preparations are not only effective in their treatment, but often cause skin redness, swelling or skin scleroderma and worsen acne in severe cases. In addition, since the use of hormonal preparations may cause systemic side effects, it is necessary to pay considerable attention to its use, and it is known that the use of antibiotics such as tetracycline may cause side effects of the emergence of resistant bacteria or photosensitization.

In view of the above-mentioned problems, the present inventors have excellent antimicrobial activity against propionibacterium acne known as the main cause of acne, and systematic research and experiments with various natural products to develop a high-safety material even for a long time use. As a result, it was found that the face washes, soaps, and creams containing leaflet extracts and / or haegeum extracts having strong antibacterial effects at low concentrations against acne bacteria have a surprisingly excellent antibacterial effect on acne bacteria and complete the present invention. Was done.

The present invention relates to a composition for the prevention and treatment of acne, characterized in that it contains at least one of the leaflet extract or Haegeumsa extract.

In the composition according to the present invention, at least one dry powder of the lobular extract or the haze extract is preferably contained in an amount of 0.01 to 10% by weight based on the total amount of the composition. The addition of at least one leaf extract or haegyeoksa extract less than 0.01% by weight was found to have a slightly lower bactericidal power.

<General features of leaflet>

Lobules (蘇葉) used as a feature of the present invention is also known as the perilla as honey grass and plants, and is native to China. Stems stand straight, 20-80 cm high, rectangular in cross section, mauve, fragrant. The leaves are opposite, broad egg-shaped, pointed at the end, rounded at the bottom, and serrated at the edges. It has hairs on both sides of the leaves, long hairs on the back side, and petioles are long. In oriental medicine, the leaves are called lobules and seeds, which are used for sweating, antitussive, dry stomach, diuretic, soothing and analgesic. When you have food poisoning, you can drink the juice from the leaves or boil the leaves. Sugar made with perylaldehyde in leaflets is 2,000 times stronger than normal sugar, so it is used for tobacco and toothpaste.

Lobules are known to contain proteins, sugars, fiber, ash, calcium, iron, vitamins A, B1, B2, and C. In addition, leaflets are rich in linoleic acid, which has a cholesterol-removing effect, and their unique fragrance stimulates appetite.

<General features of the lifter>

Haegeumsa (海金沙) is a spore of the fern family and is used as a medicinal herb. Ferns are ferns that have flourished since the late Devonian period, and grow in warm and humid places, and have spore-shaped spores on the back of mature leaves, and spores grow in them. Have In particular, Haegeumsa is a perennial vine herb that is distributed in the foothills of Jeolla-do, Gyeongsang-do, South Korea, and in China's South, South, China, Southwest and Northwest. .

These haegeums belong to the Schizaeaceae, and their origin is defined as Lygodium japonica in Korea and China, and the Latin name is Spora Lygodii. Haegeumsa shows a difference in composition and composition depending on the production area, but the organic matter including oil by extraction or degreasing is 12 to 14% by weight.As a result of analyzing the residues of haegeumsa, the carbon value derived from components such as cellulose, ligrin, hemicellulose, etc. It is composed of about 14 to 18% by weight of inorganic matters 68 to 74% by weight. The inorganic components include iron (Fe) of 7 to 12, silicon (Si) of 13 to 18, aluminum (Al) of 3.5 to 6.5, calcium (Ca) of about 3 to 4, magnesium (Mg) of 1 to Trace amounts of dipotassium (K) and phosphorus (P) and oxygen resulting from the oxide are about 25 to 45% by weight. The minerals contained in these Haegeumsa are mainly derived from the inorganic elements that permeate the soil, and the soil difference of each mountain region leads to the difference in composition.

Haegeum has traditionally been used as an herbal herb for herbal medicines such as urinary tract infections, urethral stones, nephritis, and infection fever, and research on hepatitis, fracture, syphilis, and prostatitis has been reported.

<Manufacture of leaf leaf extract and haegum sand extract>

Referring to the method for extracting leaflets and haegeum used as a feature of the present invention. First, the leaflets and haegeum sasa were purified and powdered and cooled at room temperature for 5 days in about 10 times the amount of the extraction solvent, and then the extract powder was dried, and the dried powders of the extracts of the leaves and haegeum sasa were filtered, concentrated and lyophilized. Extractive solvents of the leaf and haegeum extract include one or two of purified water, ethanol, propanol, butanol, glycerol, propylene glycol, 1,3-butylene glycol, methyl acetate, ethyl acetate, benzene, hexane, diethyl ether, and dichloromethane. More than kinds of solvents were mixed and used for extraction.

<Evaluation of Antimicrobial Activity against Acne Bacteria from Leafy Leaf Extracts and Haegumsa Extracts>

Antimicrobial activity of the extract obtained by the above method was added to the acne bacteria (propionibacterium acne) cultured in a liquid medium by adding a leaflet extract and haegeum extract of a certain concentration to inhibit the growth of acne bacteria after culturing in an anaerobic culture tank The minimum inhibitory concentration (MIC) was calculated. As a result, the range of minimum inhibitory concentration (MIC) for acne bacteria of leaflet extract and haegyeoksa extract by each extract was evaluated as 10 to 100 ppm. Excellent antimicrobial effect was confirmed.

The present inventors included leaflet extracts and haegeum extracts in compositions such as face washes, soaps, and creams to evaluate bactericidal activity against acne bacteria (cleansing agents, soaps, creams) and clinical trials for evaluating acne treatment effects. It was found that the composition containing at least one of the extract and haegeum sasa extract has excellent acne treatment effect without showing side effects such as skin redness.

In more detail, the present invention provides a composition of 1) cleansing agent, 2) soap or 3) cream for acne prevention and treatment containing at least one of the leaflet extract and haegyeosa extract obtained by the above method. . Each composition is based on the base of each product in general, which does not contain excess fat, and for each of the respective compositions, acne prevention and / or acetic acid prevention, characterized in that it contains 0.01 to 10% by weight of dry powder of leaf extracts and / or sea urchin extracts. A therapeutic composition.

According to the present invention, the cleansing agent and the soap contain at least one of the leaflet extract and the haemulsa extract in the cleansing agent and the soap base, in addition to the salicylic acid, alpha-hydroxy acid (α-hydroxy acid), beta hydride to increase the clinical effect It may be used by adding kelatolytic or exfoliating agents such as β-hydroxy acid or sulfur. In addition, fragrances, pigments, fungicides, antioxidants, preservatives, moisturizers and the like can be used, and thickeners, inorganic salts, synthetic polymers and the like can be used for improving the properties. In addition, the cream contains at least one of the leaflet extract and Haegeum extract from the base of the general oil-in-water (O / W) and can use fragrances, pigments, antioxidants, preservatives, etc., synthetic or natural materials to improve the properties There is a number.

The face wash, soap and cream according to the present invention can be easily prepared by conventional manufacturing methods. Hereinafter, although this invention is demonstrated concretely based on an Example and a comparative example, this invention is not restrict | limited to these Examples in any way.

Example 1-Face Wash

99.99% by weight of the cleansing agent base (including water) and 0.01% by weight of dry powder of leaflet extract was prepared in a homomixer through a process such as stirring, heating, degassing and cooling to prepare the composition of the cleansing composition so as to uniformly mix. By using the method, a facial cleanser containing at least one leaf extract or haegeum extract may be prepared.

[Table 1] (Unit: weight%)

Raw material name Example
One Example
2 Example
3 Example
4 Example
5 Example
6 Example
7 Example
8 Example
9 1. Glycerin  5.00  5.00  5.00  5.00  5.00  5.00  5.00  5.00  5.00 2.monoalkyl phosphates 40.00 40.00 40.00 40.00 40.00 40.00 40.00 40.00 40.00 3.Sodium hydroxide (50%) 15.00 15.00 15.00 15.00 15.00 15.00 15.00 15.00 15.00 4. Myristic acid  5.00  5.00  5.00  5.00  5.00  5.00  5.00  5.00  5.00 5. Leaflet extract  0.01  - 0.005 1.0 - 0.5 10.0 - 5.0 6. Haegumsa Extract - 0.01 0.005 - 1.0 0.5 - 10.0 5.0 7. Spices Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount 8. Purified water 34.99 34.99 34.99 34.90 34.0 30.0 25.0 25.0 25.0

Raw material name Comparative Example
One Comparative Example
2 Comparative Example
3 Comparative Example
4 Comparative Example
5 Comparative Example
6 Comparative Example
7 1. Glycerin  5.00  5.00  5.00  5.00  5.00  5.00  5.00 2.monoalkyl phosphates 40.00 40.00 40.00 40.00 40.00 40.00 40.00 3. Sodium hydroxide (50%) 15.00 15.00 15.00 15.00 15.00 15.00 15.00 4. Myristic acid  5.00  5.00  5.00  5.00  5.00  5.00  5.00 5. Lobules Extract - 0.005 - 0.0025 11.0 - 5.5 6. Haegeumsa Extract - - 0.005 0.0025 - 11.0 5.5 7. Spices Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount 8. Purified water 34.995 34.995 24.00 34.995 34.995 24.00 24.00

Experimental Example 1: Test for bactericidal power against acne bacteria (propionibacterium acnes) (cleanser)

In order to confirm the acne prevention and treatment effect of the facial cleanser composition prepared in Examples and Comparative Examples of Table 1, after inoculating acne bacteria (propionibacterium acnes) to the Patridish (bacterial culture dish) for 3 days anaerobic It can then were cultured in the culture tank and measuring the colony number (N ₁₎ of the acne bacteria, drop the examples and comparative examples, cleanser aqueous solution of 5% on the Petri dishes were incubated in an anaerobic culture tank for more than three days colonies (N ₂ ) Was measured. The number of colonies obtained by the above was evaluated using the following method for the sterilization rate for acne bacteria.

The bactericidal rate of acne bacteria (propionibacterium acnes) is determined to have a bactericidal effect only when the result is more than 90%.

Experimental Example 2: Clinical Experiment of Preventing and Treating Acne (Cleanser)

Men in their late teens to late twenties to determine the clinical effects of acne prevention and treatment using facial cleansers (Examples 4, 5, 6 and Comparative Example 1) prepared in Examples and Comparative Examples of Table 1 above. (20 patients per experiment group) were selected as subjects and used three times a day for one month to evaluate the effects of acne prevention and treatment.

Judging method is to determine the reduction of the cotton cloth by visual observation after a certain rating according to the condition of acne before the start of the experiment.

Rating condition 0   Normal state One   Very small number or size of cotton cloth or no inflammation 2   Inflammation does not progress moderately in number or size of cotton cloth 3   Scrub with a small number of inflammatory papules 4   Small and widespread nodules and inflammatory scalp 5   Small number and size of papular nodules 6   Moderate inflammatory nodules 7   A large number of inflammatory nodules are present 8   Severe nodular sclera 9   Severe cystic and inflammatory nodules are present

It is judged that the grade of acne of the clinical trial subjects is more than 3 grades, the effect is excellent, if the decrease of 1 to 2 is moderate, the effect is no, if the decrease does not appear, the grade after the test is worse than the grade before the trial.

The results for the above experiments are shown in Table 2 below.

Table 2-1 (Cleanser): Results of bactericidal activity against acne bacteria (Propionibacterium acnes)

Example
One Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 Example 9 First culture
Acne bacteria count (N ₁ ) 756 578 514 436 512 674 488 578 665 Number of Acne Bacteria after 3 Days of Washing Solution (N ₂ )  75  58  51  21  23 29  0 0   0 Sterilization Rate of Acne Bacteria (%) 90.1 90.0 90.1 95.2 95.5 95.7 100.0 100.0 100.0 Workability Good Good Good Good Good Good Good Good Good

Comparative Example
One Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Comparative Example 7 First culture
Acne bacteria count (N ₁ ) 756 515 327 554 512 874 564 Number of Acne Bacteria after 3 Days of Washing Solution (N ₂ ) 425  220 149 228 0   0 0 Sterilization Rate of Acne Bacteria (%) 43.8 57.3 54.4 58.8 100.0 100.0 100.0 Workability Good Good Good Good Bad Bad Bad

Table 2-2 (Cleanser): Clinical Trial Results for Preventing and Treating Acne

                                                             Unit: persons (%)

Rating
Kinds Excellent effect Effect medium no effect Worse Side Effect
(Skin redness, etc.) system Example 4 14 (70%) 6 (30%) 0 (0%) 0 (0%) 0 (0%) 20 (100%) Example 5 13 (65%) 7 (35%) 0 (0%) 0 (0%) 0 (0%) 20 (100%) Example 6 14 (70%) 5 (25%) 1 (5%) 0 (0%) 0 (0%) 20 (100%) Comparative Example 1 0 (0%) 6 (30%) 10 (50%) 4 (20%) 0 (0%) 20 (100%)

As shown in Table 2, the cleansing agent containing at least one of the leaflet extract or Haegumsa extract was found to be superior to the bactericidal power against acne bacteria, even in clinical trials. Appeared to be. In addition, as shown in the above results, the addition of less than 0.01% by weight of at least one leaf leaf extract or haegyeoksa extract showed that the sterilization power was slightly lower, and more than 10% by weight, the sterilization power was excellent, but there was difficulty in manufacturing. . Therefore, the content of one or more of the leaflet extract or haegeum extract in the face wash used in the present invention was found to be very good sterilizing power and workability against acne bacteria within the range of 0.01 to 10% by weight.

Example 2-Soap

99.99% by weight of the soap base (including moisture and various additives) and 0.01% by weight of the dry powder of the leaflet extract were mixed well in a mixer, followed by extrusion, cutting and molding in a soap manufacturing machine to prepare a soap composition in the form of a solid soap. At least one extract of the leaflet extract or haegeum sasa extract of can be prepared by including not only general soap, but also synthetic soap and composite soap by a conventional soap production method.

[Table 3]

                                                          (Unit: weight%)

Raw material name Example
One Example
2 Example
3 Example
4 Example
5 Example
6 Example
7 Example
8 Example
9 1. Soap Base
(13% moisture included)  99.99 99.99 99.99 99.0 99.0 99.0 90.0 90.0 90.0 2. Leaflet extract   0.01  -   0.005  1.0 -  0.5 10.0 -  5.0 3. Haegumsa Extract -  0.01   0.005 -  1.0  0.5 - 10.0  5.0 4. Spices Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount

Raw material name Comparative Example
One Comparative Example
2 Comparative Example
3 Comparative Example
4 Comparative Example
5 Comparative Example
6 Comparative Example
7 1. Soap Base
(13% moisture included) 100.0 99.995 99.995 99.995 89.0 89.0 89.0 2. Leaflet Extract -  0.005 -  0.0025 11.0 - 5.5 3. Haegeumsa Extract - -  0.005  0.0025 - 11.0 5.5 4. Spices Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount

Experimental Example 3: Test for bactericidal power against acne bacteria (propionibacterium acnes) (soap)

3 days after the inoculation of acne bacteria (propionibacterium acnes) to the petri dish (bacterial culture dish) to confirm the acne prevention and treatment effect on the soap composition prepared in Examples and Comparative Examples of Table 3 After culturing in an anaerobic culture tank and the colony number of acne bacteria (N ₁ ) was measured, 5% of the example and comparative soap solution was dropped on a petri dish and incubated in an anaerobic culture tank for 3 days or more. ₂ ) was measured. The number of colonies obtained by the above was evaluated using the following method for the sterilization rate for acne bacteria.

The bactericidal rate of acne bacteria (propionibacterium acnes) is determined to have a sterilizing effect when the result is 90% or more. The bactericidal power test results for acne bacteria (propionibacterium acnes) of the soap composition are shown in Table 4 below.

[Table 4]

Example
One Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 Example 9 First culture
Acne bacteria count (N ₁ ) 526 478 414 438 512 644 588 478 605 Acne bacteria count after 3 days of soap solution (N ₂ ) 50  47  40  20  20 25  0 0   0 Sterilization Rate of Acne Bacteria (%) 90.5 90.2 90.3 95.4 96.1 96.1 100.0 100.0 100.0 Workability Good Good Good Good Good Good Good Good Good

Comparative Example
One Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Comparative Example 7 First culture
Acne bacteria count (N ₁ ) 556 505 427 398 554 512 874 Acne bacteria count after 3 days of soap solution (N ₂ ) 302 222 200 188 0 0   0 Sterilization Rate of Acne Bacteria (%) 45.7 56.0 53.2 52.8 100.0 100.0 100.0 Workability Good Good Good Good Bad Bad Bad

As shown in Table 4, the soap containing at least one of the leaflet extract or Haegeumsa extract was found to be superior to the bactericidal power against acne bacteria than the soap does not contain it. As shown in the above results, the addition of less than 0.01% by weight of leaflet extract or haegyeoksa extract was found to have a slightly lower bactericidal power. When it exceeds 10% by weight, the bactericidal power was excellent, but there were manufacturing difficulties. Therefore, the content of at least one leaf leaf extract or haegeum sand extract in the soap used in the present invention was found to be very good sterilizing power and workability against acne bacteria within the range of 0.01 to 10% by weight.

Example 3-Cream

A cream composition was prepared by emulsifying the dry powder of the leaflet extract in an amount of 99.99% by weight (including water) of a combination of an oily component, an aqueous component, and a surfactant, which was a cream base, in a mixer, degassing, filtering, and cooling. Other additives, such as preservatives, chelating agents, fragrances and pigments, may be added. The formulation is formulated in water type (O / W) so that a small amount of oily ingredients are present. It can be conveniently added to basic cosmetics such as essences and used as an agent for preventing and treating acne.

 [Table 5]

                                                              (Unit: wt%)

Raw material name Example
One Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 Example 9 1. Stearic acid  8.00  8.00  8.00  8.00  8.00  8.00  8.00  8.00  8.00 2. Stearyl alcohol  4.00  4.00  4.00  4.00  4.00  4.00  4.00  4.00  4.00 3. Butyl Stearate  6.00  6.00  6.00  6.00  6.00  6.00  6.00  6.00  6.00 4. Propylene Glycol  5.00  5.00  5.00  5.00  5.00  5.00  5.00  5.00  5.00 5. Glycerin Monostearate  2.00  2.00  2.00  2.00  2.00  2.00  2.00  2.00  2.00 6. Potassium Hydroxide  0.40  0.40  0.40  0.40  0.40  0.40  0.40  0.40  0.40 7. Leaflet Extract  0.01  -   0.005  1.0 -  0.5 10.0 -  5.0 8. Haegumsa Extract -  0.01   0.005 -  1.0  0.5 - 10.0  5.0 9. Spices Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount 10. Preservative Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount 11. Purified water 74.59 74.59 74.59 73.60 73.60 73.60 64.60 64.60 64.60

Raw material name Comparative Example
One Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Comparative Example 7 1. Stearic acid  8.00  8.00  8.00  8.00  8.00  8.00  8.00 2. Stearyl alcohol  4.00  4.00  4.00  4.00  4.00  4.00  4.00 3. Butyl Stearate  6.00  6.00  6.00  6.00  6.00  6.00  6.00 4. Propylene Glycol  5.00  5.00  5.00  5.00  5.00  5.00  5.00 5. Glycerin Monostearate  2.00  2.00  2.00  2.00  2.00  2.00  2.00 6. Potassium Hydroxide  0.40  0.40  0.40  0.40  0.40  0.40  0.40 2. Leaflet Extract -  0.005 -  0.0025 11.0 - 5.5 3. Haegeumsa Extract - -  0.005  0.0025 - 11.0 5.5 9. Spices Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount 10. Preservative Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount 11. Purified water 74.59 74.59 74.59 73.60 73.60 73.60 64.60

Experimental Example 4: Test bactericidal power (acne) against acne bacteria (propionibacterium acnes)

3 days after the inoculation of acne bacteria (propionibacterium acnes) to the petri dish (bacterial culture dish) to confirm the acne prevention and treatment effect on the cream composition prepared in Examples and Comparative Examples of Table 5 After culturing in an anaerobic culture tank and the colony count of acne bacteria (N ₁ ) was measured, 5% of the aqueous solution of Examples and Comparative Examples was dropped on a petri dish and incubated in an anaerobic culture tank for at least 3 days, and then the colony (N ₂ ) was measured. The number of colonies obtained by the above was evaluated using the following method for the sterilization rate for acne bacteria.

The bactericidal rate of acne bacteria (propionibacterium acnes) is determined to have a bactericidal effect only when the result is 90% or more. The bactericidal power test results for acne bacteria (propionibacterium acnes) of the cream composition are shown in Table 6 below.

TABLE 6

Example
One Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 Example 9 First culture
Acne bacteria count (N ₁ ) 400 408 414 448 502 604 532 578 505 Number of acne bacteria after 3 days of applying cream solution (N ₂ ) 39  40  40  22  22 25  0 0   0 Sterilization Rate of Acne Bacteria (%) 90.3 90.2 90.3 95.1 95.6 95.8 100.0 100.0 100.0 Workability Good Good Good Good Good Good Good Good Good

Comparative Example
One Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Comparative Example 7 First culture
Acne bacteria count (N ₁ ) 556 515 437 498 554 554 455 Number of acne bacteria after 3 days of applying cream solution (N ₂ ) 302 222 201 199 0 0   0 Sterilization Rate of Acne Bacteria (%) 45.7 56.9 54.0 60.0 100.0 100.0 100.0 Workability Good Good Good Good Bad Bad Bad

As shown in Table 6, the cream containing at least one leaf leaf extract or haegeum sasa extract was found to be superior to the bactericidal power against acne bacteria than the cream does not contain it. As shown in the above results, the addition of less than 0.01% by weight of leaflet extract or haegyeoksa extract showed a slightly lower germicidal power. Therefore, the content of at least one leaf leaf extract or haegeum sand extract in the cream used in the present invention was found to be very good sterilizing power and workability against acne bacteria within the range of 0.01 to 10% by weight.

Taken together, the cleansing, soap or cream compositions containing 0.01 to 10% by weight of leaflet extracts and / or haegeum extracts were evaluated to have an excellent antibacterial effect on acne bacteria and to prevent and treat acne. Is evaluated.

Claims (5)

Acne improvement cosmetic composition comprising a leaf extract (Perilla frutescens) and haegosa extract (lygodium japonicum) as an active ingredient. The method of claim 1, The leaflet extract and haegeum sasa extract each of the cosmetic composition for acne improvement comprising 0.01 to 10% by weight relative to the total composition. The method of claim 1, The leaflet extract and haegeum extract are one or more selected from purified water, ethanol, propanol, butanol, glycerol, propylene glycol, 1,3-butylene glycol, methyl acetate, ethyl acetate, benzene, hexane, diethyl ether and dichloromethane. Acne improvement cosmetic composition is an extract obtained by evaporating or freeze drying the solvent after cooling at room temperature using a mixed solvent. The method of claim 1, Wherein the cosmetic composition for improving acne is a cosmetic composition for improving acne that is formulated with a face wash, soap or cream. delete