CN110075046A - It is a kind of can the light trace of Eradicates acne composition - Google Patents
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61P17/10—Anti-acne agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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Abstract
The invention discloses it is a kind of can the light trace of Eradicates acne composition, include Radix Salviae Miltiorrhizae root extract, cloves alabastrum extract, Baical Skullcap root P.E, papain, Aloe Barbadensis Miller powder, asiaticosid, dipotassium glycyrrhizinate and o- cymene -5- alcohol.Composition of the present invention is cooperated jointly using cloves alabastrum extract and papain, as the Transdermal absorption for promoting plant to remove acne renovation agent (Radix Salviae Miltiorrhizae root extract, Baical Skullcap root P.E, Aloe Barbadensis Miller powder, asiaticosid), the composition is other than adding plant component, it also added dipotassium glycyrrhizinate and o- cymene -5- alcohol, it can be compounded with plant component, on the one hand the irritation of chemicals is reduced, on the other hand the inhibitory effect for causing the bacterium of acne can be improved, reaches more preferably fungistatic effect.Change and dredge pore, be able to suppress the growth of pathogenic bacteria in hair follicle, improves follicular keratosis.The present invention also provides it is a kind of comprising it is described can the light trace of Eradicates acne composition skin care item.
Description
Technical field
The present invention relates to cosmetic technical fields, and in particular to it is a kind of can the light trace of Eradicates acne composition.
Background technique
Acne is a kind of common skin problem, and acne is by hair follicle and sebum adenemphraxis, pilosebaceous follicle inflammation institute
A kind of skin disease caused.Sebaceous glands is opened on follicular orifice more, once follicular orifice blocks, excessive sebum metabolism generates excessive
The effect of the propionibacterium acnes of hyper-proliferative, makes skin produce inflammatory reaction in the stimulation of fatty acid and enclosed environment,
The lipase that propionibacterium acnes generate decomposes sebum and generates free fatty acid, while chemotactic inflammatory cell and medium, final to induce
And aggravate inflammatory reaction.Therefore the performance of small pox is from gently to being hoary hair's blackhead, inflamed papules and useless fellow, tumour and knot again
Section, and small pox that is rubescent and suppurating is to have existing for bacterium infection, acne is mainly in puberty, when puberty, intracorporal He Er
Illiteracy can stimulate hair growth, promote smegma more many greases of sauce, and therefore hair and sebaceous glands accumulate many substances, acne is also named
" whelk ", " whelk " are easy to influence personal image, are easy to cause self-confidence insufficient, self-esteem is impaired, and depression etc. is a series of
Psychological problems cause human communication disorders or influence employment.
Currently, many anti-acne (acne of dispelling) products use hormone, antibiotic, vitamin A acid, the ingredients such as tartaric acid, irritation is big,
Skin is easily caused to the drug resistance of Propiobacterium, safety is constantly under suspicion.It is past in existing natural composition product for resolving poxes
Carry out anti-inflammation and sterilization toward only single selection natural extract, solved the problems, such as not for the bacterium of caused acne,
So the speed that takes effect is frequently not quickly.It is small to skin irritation, mildly, fast and effective product for resolving poxes, it has also become nowadays acne
The primary selection of skin is continuously improved in particular with people's living standard, and the requirement to health and environmental protection is also higher and higher.Mesh
Before, the limitation that commercially available skin care item itself are formulated can only achieve mitigation symptom to a certain extent, and anti-acne effect is undesirable, and
Period is longer, and ideal effect is not achieved at all to more serious acne.How the cause and triggering of acne complexity are combined
Mechanism designs and develops skin-protection product that is more effective and can reaching anti-acne for a long time, desalinate acne print effect, is current skin care research neck
A technical problem existing for domain.
Summary of the invention
There is provided it is an object of the invention to overcome in place of the shortcomings of the prior art it is a kind of can the light trace of Eradicates acne combination
Object.
To achieve the above object, the technical scheme adopted by the invention is as follows: it is a kind of can the light trace of Eradicates acne composition, include Radix Salviae Miltiorrhizae
Root extract, cloves alabastrum extract, Baical Skullcap root P.E, papain, Aloe Barbadensis Miller powder, asiaticosid, glycyrrhizic acid
Dipotassium and o- cymene -5- alcohol.
It is rich in tanshinone, sterol, flavonoids and other functional ingredient in Radix Salviae Miltiorrhizae root extract, hair follicle, equilibrium oil can be goed deep into
Rouge secretion inhibits propionibacterium acnes flora related to other acnes, mitigates inflammation;Radix scutellariae root extract is rich in flavonoid
Object has antibacterial and contraction and other effects.Contain triterpene compound in asiaticosid, antioxidant in skin wound can be promoted
Concentration and by increase blood supply repair Inflamed tissue, repair skin as early as possible.The extraction material of cloves alabastrum extract is
The dry flower of plant clove of myrtaceae Eugenia caryophyllataThunb., wherein contain eugenol, chemistry knot
The polar group on aromatic rings on structure can destroy microorganism normal generation in conjunction with the active group of enzymes certain in microorganism
It thanks to function, has the function that inhibit fungi, bacterium, additionally it is possible to promote Drug Percutaneous Absorption.Papain can effectively remove acne
The cutin of the dyskeratosis of acne skin and the cutin of blocking pore, also can speed up small pox cut and absorb functional component.Ku La
There is good bacteriostasis rich in the anthraquinones having in rope Chinese aloe leaf powder, can effectively inhibit common and small pox is caused to generate
The microbial growths such as staphylococcus epidermis, propionibacterium acnes, pityrosporum furfur, human body demodex folliculorum;It enriches simultaneously
Aloe polysaccharide substance can accelerate the quick reparation of hair follicle inflammation.Dipotassium glycyrrhizinate is adjustable cell sebum balance, has suppression
Bacterium, anti-inflammatory, removing toxic substances, antiallergic and other effects.O- cymene -5- alcohol has infiltration bactericidal effect.
The present invention is cooperated jointly using cloves alabastrum extract and papain, removes acne renovation agent as promotion plant
The Transdermal absorption of (Radix Salviae Miltiorrhizae root extract, Baical Skullcap root P.E, Aloe Barbadensis Miller powder, asiaticosid), the composition is in addition to adding
Add outside plant component, also added dipotassium glycyrrhizinate and o- cymene -5- alcohol, can compound with plant component, on the one hand reduce
On the other hand the irritation of chemicals can improve the inhibitory effect for causing the bacterium of acne, reach more preferably fungistatic effect.Change and
Pore is dredged, the growth of pathogenic bacteria in hair follicle is able to suppress, improves follicular keratosis.
Preferably, the component comprising following weight percentage: Radix Salviae Miltiorrhizae root extract 1~3%, cloves alabastrum extract 1
~3%, Baical Skullcap root P.E 1~3%, papain 1~3%, Aloe Barbadensis Miller powder 0.1~0.5%, asiaticosid 0.1
~0.5%, dipotassium glycyrrhizinate 0.1~0.3% and o- cymene -5- alcohol 0.05~0.1%.Inventors have found that each ingredient is upper
It states under proportion, Transdermal absorption, inhibiting bacteria and diminishing inflammation and the effect for improving follicular keratosis can be given full play to.
Preferably, the component comprising following weight percentage: Radix Salviae Miltiorrhizae root extract 2%, cloves alabastrum extract 2%,
Baical Skullcap root P.E 2%, papain 2%, Aloe Barbadensis Miller powder 0.3%, asiaticosid 0.3%, dipotassium glycyrrhizinate 0.2%
With o- cymene -5- alcohol 0.08%.Especially under said ratio, anti-acne effect and the effect for repairing scar are best.
Preferably, can the light trace of Eradicates acne composition also include following weight percentage component: 1,2- hexylene glycol 3~
5%, the butanediol of pentanediol 3~5% and surplus.
The object of the invention is also to provide it is a kind of comprising it is described can the light trace of Eradicates acne composition skin care item.
Preferably, the skin care item are aqua, emulsion or paste.
Skin care item of the present invention can be toner, essence, facial mask, lotion or creams.It is defined except said components have
Requirement outside, in the range of lossless effect of the invention, those skilled in the art can add according to specific skin care item dosage form
Add or use other adjunct ingredients.
The beneficial effects of the present invention are: the present invention provides it is a kind of can the light trace of Eradicates acne composition.Of the present invention group
It closes object to cooperate jointly using cloves alabastrum extract and papain, as promoting plant to remove acne renovation agent, (red sage root is extracted
Object, Baical Skullcap root P.E, Aloe Barbadensis Miller powder, asiaticosid) Transdermal absorption, the composition in addition to add plant component
Outside, dipotassium glycyrrhizinate and o- cymene -5- alcohol be also added, can be compounded with plant component, on the one hand reduce the thorn of chemicals
Swash property, on the other hand can improve the inhibitory effect for causing the bacterium of acne, reach more preferably fungistatic effect.Change and dredge pore,
It is able to suppress the growth of pathogenic bacteria in hair follicle, improves follicular keratosis.The present invention also provides one kind comprising it is described can Eradicates acne it is light
The skin care item of the composition of trace.
Specific embodiment
In the embodiment of the present invention, main raw material sources are as follows, other raw materials are purchased from market: Radix Salviae Miltiorrhizae (SALVIA
MILTIORRHIZA) root extract is purchased from Xi'an Yuan Sen Biotechnology Co., Ltd;Cloves (EUGENIA CARYOPHYLLUS)
Alabastrum extract is purchased from Lanzhou water Lai Si Biotechnology Co., Ltd;Radix Astragali (ASTRAGALUS MEMBRANACEUS) root mentions
Taking object is the Q-200657 produced purchased from Switzerland BIOSYNTH;Papain is purchased from Xi'an Bai Chuan Biotechnology Co., Ltd,
Enzymatic activity is ten thousand unit of 100-120, molecular weight 21000-23000.The purchase of aloe barbadensis Miller (AlOE BARBADENSIS) leaf powder
From Tongxiang City Kang Puda Biotechnology Co., Ltd;Asiaticosid is purchased from Xi'an Bo Liante Chemical Co., Ltd..
To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention
It is described further.
Examples 1 to 5 and comparative example 1~4
Described in Examples 1 to 5 and comparative example 1~4 can the formula of composition of the light trace of Eradicates acne be shown in Table 1.
Described in 1 Examples 1 to 5 of table and comparative example 1~4 can the light trace of Eradicates acne composition
Embodiment 6
For verify it is of the present invention can the light trace of Eradicates acne composition antibiosis effect, referring to GB15979-2002
" Disposable Sanitary Accessory sanitary standard " appendix C 4 " stripping property resists (suppression) bacterium product bacteriostasis property test method " is to this hair
Described in bright Examples 1 to 5 and comparative example 1~4 can the light trace of Eradicates acne composition carry out bacteriostasis property measurement: (1) system of bacteria suspension
Standby: taking propionibacterium acnes, culture is washed down with 0.03mol/L phosphate buffer for 24 hours, and it is outstanding that 104~106CFU/mL bacterium is made
Liquid;(2) it is taken respectively by test agent 1g, above-mentioned bacteria suspension 0.1mL even spread mixing is added, starts timing, is added after 20min
9mL0.03mol/L phosphate buffer mixes well, and after doing appropriate dilution, takes wherein 3 dilutions, takes 1mL to be placed in two respectively
In a parallel plate, adds corresponding culture medium and cultivated 24 hours under 36 ± 1 DEG C of anaerobic conditions, make bacterium colony counting.The above examination
It tests and is repeated 3 times, be averaged, blank control group is set.
The calculation formula of bacteriostasis rate are as follows: X=(A-B)/A × 100%, wherein X is bacteriostasis rate, and A is that control sample averagely returns
Bacterium colony is received, B is that test specimen averagely recycles bacterium colony.
Acne-removing evaluation criterion are as follows: (1), bacteriostasis rate >=90% be it is effective;(2), it is effective that bacteriostasis rate, which is 50~90%,;
(3), bacteriostasis rate < 50% is invalid.
Described in Examples 1 to 5 and comparative example 1~4 can the light trace of Eradicates acne composition bacteriostasis efficacy evaluation be shown in Table 2.
Described in 2 Examples 1 to 5 of table and comparative example 1~4 can the light trace of Eradicates acne composition bacteriostasis efficacy evaluation
Group | Bacteriostasis rate (%) | Bacteriostasis efficacy evaluation |
Embodiment 1 | 98.0 | It is effective |
Embodiment 2 | 90.1 | It is effective |
Embodiment 3 | 98.5 | It is effective |
Embodiment 4 | 94.4 | It is effective |
Embodiment 5 | 95.3 | It is effective |
Comparative example 1 | 89.0 | Effectively |
Comparative example 2 | 94.0 | It is effective |
Comparative example 3 | 86.4 | Effectively |
Comparative example 4 | 80.3 | Effectively |
It can be seen that Examples 1 to 5 and the composition of comparative example 1~4 from the data of table 2 to have propionibacterium acnes
There is bactericidal and bacteriostatic effect, acne-removing is evaluated as effective or effective.And the bactericidal and bacteriostatic effect of embodiment 1 is better than comparative example 4,
Show that dipotassium glycyrrhizinate and o- cymene -5- alcohol can increase fungistatic effect.
Embodiment 7
By described in Examples 1 to 5 and comparative example 1~4 can the composition of the light trace of Eradicates acne gel is made by formula as below: can Eradicates
Composition 36%, glycerol 3%, propylene glycol 3%, hyaluronic acid 0.5%, carbomer 0.3%, the ethylenediamine tetra-acetic acid two of the light trace of acne
The deionized water of sodium 0.1%, citric acid 0.8% and surplus.
The effect of to further illustrate composition of the present invention, chooses 45 slight or moderate acne person (references
PillSburv and international improvement acne pulvis method diagnose mild or moderate acne person), wherein male 26, women 19, the age is 18
Between~30 years old, the course of disease 1~3 year, volunteer's exclusion condition met " cosmetics contact dermatitis diagnostic criteria and treatment principle "
Receive people's exclusion criteria.9 groups are equally divided into, every group of 5 people, it is desirable that every group of volunteer smears after being inferior to facial cleansing in daily early, evening two
Examples 1 to 5 and the gel of comparative example 1~4 in 8 weeks of test, are scattered and disappeared tester Tewameter with moisture of skin
TM300 carried out data acquisition to test zone respectively at the 0th, 1,4,8 week.Statistical result is anti-by transepidermal water loss TEWL value
Reflect the acne-removing of composition of the present invention.
It is detected respectively with the moisture of skin tester that scatters and disappears using before Examples 1 to 5 and the gel of comparative example 1~4 and even
Skin when continuing using 0,1,4,8 week the results are shown in Table 3 through epidermis dehydration value.
3 skin of table is through epidermis dehydration value (g/m2h)
Skin is the important parameter for assessing moisture of skin protection layer function through epidermis dehydration TEWL, and protective layer of skin is completeer
Good, TEWL value is lower.From table 3 it can be seen that after being used continuously gel 8 weeks containing composition described in Examples 1 to 5, TEWL
Value reduces 30% or more (TEWL value reduced rate=(0 week -8 week of TEWL value TEWL value)/0 week TEWL value after 8 weeks), shows this hair
Skin lesion caused by the bright composition can be repaired significantly because of acne, wherein the reduced rate of embodiment 1 is maximum (42.1%).Implement
Example 1 is compared with comparative example 1~4, Radix Salviae Miltiorrhizae root extract, cloves alabastrum extract, Baical Skullcap root P.E, papain, Curacao
Chinese aloe leaf powder, asiaticosid, dipotassium glycyrrhizinate are identical with the total amount of adding of o- cymene -5- alcohol, are not added in comparative example 1~3
Cloves alabastrum extract and/or papain, TEWL value reduced rate is lower than embodiment 1 after 8 weeks, shows that cloves bud extracts
Object and papain can promote Radix Salviae Miltiorrhizae root extract, Baical Skullcap root P.E, Aloe Barbadensis Miller powder, centella to a certain extent
The absorption of glycosides.The repairing effect of embodiment 1 is higher than the comparative example 4 for being not added with dipotassium glycyrrhizinate and o- cymene -5- alcohol.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention
The limitation of range is protected, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should
Understand, it can be with modification or equivalent replacement of the technical solution of the present invention are made, without departing from the essence of technical solution of the present invention
And range.
Claims (6)
1. one kind can the light trace of Eradicates acne composition, which is characterized in that include Radix Salviae Miltiorrhizae root extract, cloves alabastrum extract, radix scutellariae
Extract, papain, Aloe Barbadensis Miller powder, asiaticosid, dipotassium glycyrrhizinate and o- cymene -5- alcohol.
2. as described in claim 1 can the light trace of Eradicates acne composition, which is characterized in that the group comprising following weight percentage
Point: Radix Salviae Miltiorrhizae root extract 1~3%, cloves alabastrum extract 1~3%, Baical Skullcap root P.E 1~3%, papain 1~3%,
Aloe Barbadensis Miller powder 0.1~0.5%, asiaticosid 0.1~0.5%, dipotassium glycyrrhizinate 0.1~0.3% and o- cymene -5-
Alcohol 0.05~0.1%.
3. as described in claim 1 can the light trace of Eradicates acne composition, which is characterized in that the group comprising following weight percentage
Point: Radix Salviae Miltiorrhizae root extract 2%, cloves alabastrum extract 2%, Baical Skullcap root P.E 2%, papain 2%, Aloe Barbadensis Miller
Powder 0.3%, asiaticosid 0.3%, dipotassium glycyrrhizinate 0.2% and o- cymene -5- alcohol 0.08%.
4. as described in any one of Claims 2 or 3 can the light trace of Eradicates acne composition, which is characterized in that can Eradicates acne light trace
Composition also includes the component of following weight percentage: the fourth two of 1,2- hexylene glycol 3~5%, pentanediol 3~5% and surplus
Alcohol.
5. it is a kind of comprising described in any one of Claims 1 to 4 can the light trace of Eradicates acne composition skin care item.
6. skin care item as claimed in claim 5, which is characterized in that the dosage form of the skin care item is aqua, emulsion or paste.
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CN110638728A (en) * | 2019-11-14 | 2020-01-03 | 广州一一生物技术有限公司 | Skin care composition for removing acne and lightening acne marks and preparation method and application thereof |
CN110664789A (en) * | 2019-10-29 | 2020-01-10 | 广州市博之越精细化工有限公司 | Acne-curing formula and application thereof |
CN114948805A (en) * | 2021-02-23 | 2022-08-30 | 上海昆药生物科技有限公司 | Antibacterial composition containing sweet wormwood herb volatile oil and application of antibacterial composition in acne-removing skin care product |
CN115919699A (en) * | 2023-01-16 | 2023-04-07 | 广州凡岛网络科技有限公司 | Acne-removing composition and application thereof in cosmetics |
CN116270371A (en) * | 2023-05-23 | 2023-06-23 | 广州瑞誉化工科技有限公司 | Mild pore-shrinking blackhead-removing composition, blackhead liquid, nose patch and daily chemical product |
CN116407478A (en) * | 2023-05-11 | 2023-07-11 | 杭州以息互联网科技有限公司 | Mild acne-removing composition and application thereof |
CN114948805B (en) * | 2021-02-23 | 2024-06-07 | 上海昆药生物科技有限公司 | Antibacterial composition containing sweet wormwood volatile oil and application of antibacterial composition in acne-removing skin care product |
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