CN110664789A - Acne-curing formula and application thereof - Google Patents
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- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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Abstract
The invention discloses a acne-curing formula and application thereof. A kepox formulation comprising: dichlorobenzyl alcohol, potassium nonanedioyl diglycoate, o-cymene-5-ol and propylene glycol. Preferably, the composition comprises the following components in percentage by weight: 5% of dichlorobenzyl alcohol, 30% of potassium nonanedioyl diglycoate, 5% of o-cymene-5-alcohol and 60% of propylene glycol. The acne-curing formula disclosed by the invention has a killing effect on a wide range of microorganisms, has a good bacteriostatic effect on fungi, can improve the survival rate of cells, enables the skin to recover normal texture, achieves the effect of treating both symptoms and root causes, is very safe in components, is a broad-spectrum bacteriostatic agent capable of contacting mucosa, and can be widely popularized and applied. The invention further provides an application of the acne-curing formula in cosmetics, medical pharmacy and bacteriostatic mite-killing products. Preferably, the acne-curing formula accounts for 0.2-2% of the addition amount of the acne-curing formula in cosmetics, medical pharmacy and bacteriostatic mite-removing products.
Description
Technical Field
The invention relates to the technical field of acne removal, and particularly relates to an acne removing formula and application thereof.
Background
The combined survey results of the Chinese dermatosis society and the Chinese teenager union show that the incidence of the acne in China is on the trend of increasing year by year, and more than 80 percent of the young people encounter the acne in different degrees. The more serious disease condition is more than 1/3 for young people.
Acne is commonly known as acne, also called as "whelk", "pimple" or "comedo", and is a skin disease caused by the blockage and inflammation of hair follicles and sebaceous glands. Pox is a chronic inflammatory skin disease of the pilosebaceous area, which is frequently seen on the face, back, chest, etc. Hypersecretion of sebum results in blockage of the pilosebaceous canal, gram-positive bacteria typical of the genus propionibacterium acnes on the skin, which are nourished by sebum in anaerobic conditions, multiply excessively, resulting in an inflammatory reaction of the skin, producing pox. The occurrence of pox and pox mark can have adverse effect on the face appearance of human body.
In the process of acne treatment, how to effectively inhibit bacteria and sterilize and make the skin recover normal texture becomes the problem which must be solved firstly.
Disclosure of Invention
Based on the situation, the invention aims to provide a acne-curing formula and application thereof.
The acne-curing formula comprises the following components: dichlorobenzyl alcohol, potassium nonanedioyl diglycoate, o-cymene-5-ol and propylene glycol.
Further preferably, the paint comprises the following components in percentage by weight: 5% of dichlorobenzyl alcohol, 30% of potassium nonanedioyl diglycoate, 5% of o-cymene-5-alcohol and 60% of propylene glycol.
Compared with the prior art, the acne-curing formula has a killing effect on a wide range of microorganisms, has a good bacteriostatic effect on fungi, can improve the survival rate of cells, enables the skin to recover normal texture, achieves the effect of treating both principal and secondary aspects of diseases, is very safe in components, is a broad-spectrum bacteriostatic agent capable of contacting mucosa, and can be widely popularized and applied.
The invention also provides an application of the acne-curing formula in cosmetics, medical pharmacy and bacteriostatic mite-killing products.
Further preferably, the addition amount of the acne-removing formula in cosmetics, medical pharmacy and bacteriostatic mite-removing products is 0.2-2%.
The acne-curing formula disclosed by the invention has the beneficial effects that:
1. has wide bactericidal effect, less adding amount and obvious bacteria inhibiting and killing effect.
2. High antibacterial and antiinflammatory effects, and can relieve inflammation and red swelling, inhibit acne bacillus proliferation, and resist irritation and sebum secretion.
3. Preventing acne, reducing blackhead, and improving skin brightness.
4. Killing fungus, removing dandruff and relieving itching.
5. Can absorb ultraviolet rays with certain wavelength and has certain oxidation resistance.
For a better understanding and practice, the invention is described in detail below with reference to the accompanying drawings.
Drawings
FIG. 1 is a graph of the results of an experiment of the anti-Propionibacterium acnes formulation of the present invention.
Figure 2 is a graph of the effect of the anti-acne formula of the invention on acne treatment.
FIG. 3 is a graph showing the variation of the antibacterial experimental process of the anti-acne formulation of the present invention.
FIG. 4 is a bactericidal test chart of the anti-acne formula of the present invention.
Fig. 5 is a graph showing the therapeutic effect of the acne-curing formulation of the present invention on pruritus.
Detailed Description
The implementations described in the exemplary embodiments below are not intended to represent all implementations consistent with the present disclosure. Rather, they are merely examples of methods consistent with certain aspects of the present disclosure, as detailed in the appended claims.
The terminology used in the present disclosure is for the purpose of describing particular embodiments only and is not intended to be limiting of the disclosure. As used in this disclosure and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It should also be understood that the term "and/or" as used herein refers to and encompasses any and all possible combinations of one or more of the associated listed items.
The acne-curing formula comprises the following components: dichlorobenzyl alcohol, potassium nonanedioyl diglycoate, o-cymene-5-ol and propylene glycol.
Preferably, the composition comprises the following components in percentage by weight: 5% of dichlorobenzyl alcohol, 30% of potassium nonanedioyl diglycoate, 5% of o-cymene-5-alcohol and 60% of propylene glycol.
Dichlorobenzyl alcohol is a broad-spectrum antibacterial agent, and the antibacterial active substance of the dichlorobenzyl alcohol can be compatible with a wide range of products, has good temperature stability and is suitable for a wide pH range. Dichlorobenzyl alcohol has an effect on a wide range of microorganisms, and has the best antibacterial effect on fungi. The broad-spectrum antibacterial activity of dichlorobenzyl alcohol is well verified in different application fields, and the dichlorobenzyl alcohol is used as an antifungal preservative in personal protection products, medicines and household products; as antifungal actives for foot creams and lotions; as bactericidal actives in cough drops, mouthwash formulations and skin preservatives; can also be used for preserving drugs, cosmetics and industrial products, effectively kill fungi and have excellent safety; can also be used together with other bactericides.
Potassium azelate is a newly developed azelaic acid derivative, is soluble in water, is low in use amount, has a good effect of regulating oil secretion, and has a stronger whitening effect. A large number of experiments prove that the cosmetic is safe and non-irritant, and can enable the formula of the cosmetic to fully exert the excellent efficacy.
o-cymene-5-ol is an antifungal agent used in cosmetics and cosmetic products to prevent the proliferation of harmful microorganisms, and also used as a cosmetic bactericide, or an ingredient to aid in skin cleansing, or to prevent odor by destroying and inhibiting the growth of microorganisms, and has an anti-acne and bactericidal effect to prolong the shelf life of the product.
The chickenpox formulation of the present invention softens and removes the first step "corner pin" that forms the chickenpox. The excessive sebum secretion is the cause of acne on the skin. After sebum enters and blocks pores, acne bacilli multiply and cause inflammation, thereby forming pox. For the generated pox, the acne-curing formula disclosed by the invention can quickly act on the pox part and practically control the excessive sebum, so that the acne-curing formula can effectively resist the causes causing the pox, inhibit the reproduction of acne bacillus, prevent rough skin, synchronously tighten pores and inhibit the excessive sebum secretion.
Please refer to fig. 1 and fig. 2.
FIG. 1 is a graph of the results of an experiment of the anti-Propionibacterium acnes formulation of the present invention. The abscissa is the addition amount of the acne-curing formula, and the graph shows that the addition amount of the acne-curing formula is gradually close to 2%, the bacteriostatic effect of the acne-curing formula on propionibacterium acnes is more and more obvious.
Figure 2 is a graph of the effect of the anti-acne formula of the invention on acne treatment. The abscissa is the addition amount of the kopox killing formula disclosed by the invention, and the figure shows that the survival rate of cells is improved along with the gradual increase of the addition amount of the kopox killing formula.
The experimental results of the combined drawings 1 and 2 show that when the acne-curing formula is applied to curing acne, the acne-curing formula can have an obvious bacteriostatic effect on propionibacterium acnes, can improve the survival rate of cells and achieve the effect of treating both principal and secondary aspect of disease, and the optimal addition amount of the acne-curing formula is 2%.
Please refer to fig. 3 and 4.
FIG. 3 is a graph showing the variation of the antibacterial experimental process of the anti-acne formulation of the present invention. The experimental result shows that the skin infection index is remarkably reduced to about 15% within 24 hours after the acne-curing formula disclosed by the invention is used for treating acne.
FIG. 4 is a bactericidal test chart of the anti-acne formula of the present invention. From the test results, it was confirmed that the anti-acne formulation of the present invention can be completely sterilized after 36 hours of treatment.
The experimental results of fig. 3 and fig. 4 show that, when the anti-bacteria and sterilization are performed by using the anti-acne formula of the invention, the skin infection index is remarkably reduced to about 15% within 24 hours after treatment, and the anti-bacteria and sterilization can be completely performed after 36 hours of treatment, so that excellent anti-bacteria and sterilization effects are achieved.
Referring to fig. 5, fig. 5 is a graph showing the effect of the anti-acne formula of the present invention on pruritus. After the acne-curing formula disclosed by the invention is used for curing 24 hours, the improvement effect on pruritus can reach about 80%.
The acne-curing formula disclosed by the invention has the main effects that:
1. inhibiting seborrhea of skin, and eliminating acne of skin.
2. Competitively inhibits tyrosinase activity, and has effects of whitening skin and removing speckle.
3. Improve the moisture retention capacity of the skin and improve the elasticity of the skin.
The acne-curing formula disclosed by the invention has a killing effect on a wide range of microorganisms, has a good bacteriostatic effect on fungi, can improve the survival rate of cells, enables the skin to recover normal texture, achieves the effect of treating both symptoms and root causes, is very safe in components, is a broad-spectrum bacteriostatic agent capable of contacting mucosa, and can be widely popularized and applied.
The invention also provides an application of the acne-curing formula in cosmetics, medical pharmacy and bacteriostatic mite-killing products.
The acne-curing formula can inhibit bacteria, remove inflammation, quickly relieve inflammation, swelling and other conditions, and has the effects of preventing acne and preventing acne deterioration; in addition, the acne-removing and sterilizing liquid has excellent acne-removing and sterilizing effects, can quickly permeate into the skin, acts from the inside of the skin, prevents acne from occurring, and fades acne marks.
Further preferably, the addition amount of the acne-removing formula in cosmetics, medical pharmacy and bacteriostatic mite-removing products is 0.2-2%.
When the addition amount of the acne-removing formula in cosmetics, medical pharmacy and bacteriostatic mite-removing products is 0.2%, the acne-removing formula can quickly kill any active microorganism, effectively inhibit the growth of various bacteria and dermatophytes, and have bacteriostatic and bacteriostatic effects.
The product efficacy of the acne-curing formula of the invention is as follows:
1. has anti-inflammatory, antiallergic and repairing effects, and has similar anti-inflammatory effect to hydrocortisone, and rapid and lasting effect.
2. Has good repairing effect on allergy, red itch, skin fragility and the like caused by hormone.
3. Has antibacterial and antiinflammatory effects, and can be used for treating acne, comedo, and skin pruritus.
4. Baby products with the functions of diminishing inflammation and relieving itching and private part nursing lotion with private part itching.
The acne-curing formula disclosed by the invention has the beneficial effects that:
1. has wide bactericidal effect, less adding amount and obvious bacteria inhibiting and killing effect.
2. High antibacterial and antiinflammatory effects, and can relieve inflammation and red swelling, inhibit acne bacillus proliferation, and resist irritation and sebum secretion.
3. Preventing acne, reducing blackhead, and improving skin brightness.
4. Killing fungus, removing dandruff and relieving itching.
5. Can absorb ultraviolet rays with certain wavelength and has certain oxidation resistance.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention.
Claims (4)
1. A acne-curing formula which is characterized by comprising: dichlorobenzyl alcohol, potassium nonanedioyl diglycoate, o-cymene-5-ol and propylene glycol.
2. The chickenpox formulation according to claim 1, comprising, in weight percent: 5% of dichlorobenzyl alcohol, 30% of potassium nonanedioyl diglycoate, 5% of o-cymene-5-alcohol and 60% of propylene glycol.
3. The use of a acne-curing formulation according to claim 1 or 2 in cosmetics, medical pharmaceuticals and bacteriostatic mite-killing products.
4. The use of the kepox formulation according to claim 3, wherein the kepox formulation is added in an amount of 0.2-2% by weight in cosmetic, medical pharmaceutical and bacteriostatic acaricidal products.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201911036061.2A CN110664789A (en) | 2019-10-29 | 2019-10-29 | Acne-curing formula and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201911036061.2A CN110664789A (en) | 2019-10-29 | 2019-10-29 | Acne-curing formula and application thereof |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101524316A (en) * | 2009-03-09 | 2009-09-09 | 兰晶 | Acne-removing cream capable of rapidly removing facial acne without leaving marks on face |
| CN102342894A (en) * | 2011-10-18 | 2012-02-08 | 薛丽 | Cosmetic capable of removing acne |
| CN107789308A (en) * | 2017-11-06 | 2018-03-13 | 诺斯贝尔化妆品股份有限公司 | A kind of gentle oil control and acne removal elite |
| CN108451782A (en) * | 2018-05-18 | 2018-08-28 | 河北博恩医药科技开发有限公司 | A kind of Whelk-eliminating paste |
| US20180311358A1 (en) * | 2015-11-05 | 2018-11-01 | Lubrizol Advanced Materials, Inc. | Thermoformable dual network hydrogel compositions |
| CN110075046A (en) * | 2019-05-29 | 2019-08-02 | 广州睿晞生化科技有限公司 | It is a kind of can the light trace of Eradicates acne composition |
-
2019
- 2019-10-29 CN CN201911036061.2A patent/CN110664789A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101524316A (en) * | 2009-03-09 | 2009-09-09 | 兰晶 | Acne-removing cream capable of rapidly removing facial acne without leaving marks on face |
| CN102342894A (en) * | 2011-10-18 | 2012-02-08 | 薛丽 | Cosmetic capable of removing acne |
| US20180311358A1 (en) * | 2015-11-05 | 2018-11-01 | Lubrizol Advanced Materials, Inc. | Thermoformable dual network hydrogel compositions |
| CN107789308A (en) * | 2017-11-06 | 2018-03-13 | 诺斯贝尔化妆品股份有限公司 | A kind of gentle oil control and acne removal elite |
| CN108451782A (en) * | 2018-05-18 | 2018-08-28 | 河北博恩医药科技开发有限公司 | A kind of Whelk-eliminating paste |
| CN110075046A (en) * | 2019-05-29 | 2019-08-02 | 广州睿晞生化科技有限公司 | It is a kind of can the light trace of Eradicates acne composition |
Non-Patent Citations (2)
| Title |
|---|
| 裘炳毅等: "《现代化妆品科学与技术 下册》", 30 March 2016 * |
| 贺尊诗等主编: "《有机药物质谱坚定》", 28 February 1996, 吉林科学技术出版社 * |
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