CN115919699A - Acne-removing composition and application thereof in cosmetics - Google Patents
Acne-removing composition and application thereof in cosmetics Download PDFInfo
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- CN115919699A CN115919699A CN202310057157.7A CN202310057157A CN115919699A CN 115919699 A CN115919699 A CN 115919699A CN 202310057157 A CN202310057157 A CN 202310057157A CN 115919699 A CN115919699 A CN 115919699A
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- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 80
- 206010000496 acne Diseases 0.000 title claims abstract description 80
- 239000000203 mixture Substances 0.000 title claims abstract description 27
- 239000002537 cosmetic Substances 0.000 title claims abstract description 17
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims abstract description 12
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000011701 zinc Substances 0.000 claims abstract description 9
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 9
- 239000004365 Protease Substances 0.000 claims abstract description 8
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 8
- 108090000526 Papain Proteins 0.000 claims abstract description 7
- 238000000855 fermentation Methods 0.000 claims abstract description 7
- 230000004151 fermentation Effects 0.000 claims abstract description 7
- 229940055729 papain Drugs 0.000 claims abstract description 7
- 235000019834 papain Nutrition 0.000 claims abstract description 7
- SCVVSSZVLZQUDZ-UHFFFAOYSA-N 3-methyl-2,6-dihydro-1H-pyrimidine-2-carboxylic acid Chemical compound CN1C(NCC=C1)C(=O)O SCVVSSZVLZQUDZ-UHFFFAOYSA-N 0.000 claims abstract description 6
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims abstract description 6
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims abstract description 6
- 229960000458 allantoin Drugs 0.000 claims abstract description 6
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims abstract description 6
- 229940059958 centella asiatica extract Drugs 0.000 claims abstract description 4
- 239000000284 extract Substances 0.000 claims description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 6
- 235000001014 amino acid Nutrition 0.000 claims description 5
- 150000001413 amino acids Chemical class 0.000 claims description 5
- 239000002738 chelating agent Substances 0.000 claims description 5
- 239000003974 emollient agent Substances 0.000 claims description 5
- 239000003995 emulsifying agent Substances 0.000 claims description 5
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- 229920003169 water-soluble polymer Polymers 0.000 claims description 5
- 239000004475 Arginine Substances 0.000 claims description 4
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 4
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 4
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 claims description 4
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 4
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- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims description 2
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 2
- KWVPFECTOKLOBL-KTKRTIGZSA-N 2-[(z)-octadec-9-enoxy]ethanol Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCO KWVPFECTOKLOBL-KTKRTIGZSA-N 0.000 claims description 2
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical group [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 2
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- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims description 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 2
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 2
- 239000004472 Lysine Substances 0.000 claims description 2
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- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims description 2
- 239000004473 Threonine Substances 0.000 claims description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 2
- 235000003704 aspartic acid Nutrition 0.000 claims description 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 2
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 2
- 229960001631 carbomer Drugs 0.000 claims description 2
- 229940073639 ceteareth-6 Drugs 0.000 claims description 2
- 229940081733 cetearyl alcohol Drugs 0.000 claims description 2
- 229960000541 cetyl alcohol Drugs 0.000 claims description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 2
- CNHQWLUGXFIDAT-UHFFFAOYSA-N dioctyl 2-hydroxybutanedioate Chemical compound CCCCCCCCOC(=O)CC(O)C(=O)OCCCCCCCC CNHQWLUGXFIDAT-UHFFFAOYSA-N 0.000 claims description 2
- 229960000735 docosanol Drugs 0.000 claims description 2
- 235000013922 glutamic acid Nutrition 0.000 claims description 2
- 239000004220 glutamic acid Substances 0.000 claims description 2
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 2
- 229920006007 hydrogenated polyisobutylene Polymers 0.000 claims description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 2
- 229960002216 methylparaben Drugs 0.000 claims description 2
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 2
- 229940093446 oleth-5 Drugs 0.000 claims description 2
- 229960005323 phenoxyethanol Drugs 0.000 claims description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 2
- 229920005862 polyol Polymers 0.000 claims description 2
- 150000003077 polyols Chemical class 0.000 claims description 2
- 239000001509 sodium citrate Substances 0.000 claims description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 2
- 229940012831 stearyl alcohol Drugs 0.000 claims description 2
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- 206010067484 Adverse reaction Diseases 0.000 description 2
- 241000186427 Cutibacterium acnes Species 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 2
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- 208000010201 Exanthema Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 235000004347 Perilla Nutrition 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
- 241000972672 Phellodendron Species 0.000 description 1
- 244000234609 Portulaca oleracea Species 0.000 description 1
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- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
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- 235000010721 Vigna radiata var radiata Nutrition 0.000 description 1
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- 235000018936 Vitellaria paradoxa Nutrition 0.000 description 1
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- 239000004480 active ingredient Substances 0.000 description 1
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 1
- 239000003098 androgen Substances 0.000 description 1
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Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Cosmetics (AREA)
Abstract
The invention relates to an acne-removing composition and application thereof in cosmetics, wherein the acne-removing composition comprises, by weight, 5-15 parts of yeast/zinc fermentation product, 0.5-5 parts of papain, 1-5 parts of tetrahydromethylpyrimidine carboxylic acid, 1-10 parts of dipotassium glycyrrhizinate, 0.1-1 part of O-cymene-5-alcohol, 0.5-5 parts of centella asiatica extract and 0.1-5 parts of allantoin; the acne-removing composition has the effects of inhibiting bacteria, diminishing inflammation, removing cutin and repairing skin barriers through a reasonable formula. In addition, when the acne cream is applied to cosmetics such as cream, essence, emulsion or gel, grease can be effectively balanced, acne can be effectively inhibited comprehensively, the acne removing effect is remarkable, and the acne cream is safe and mild, is beneficial to repairing the skin after acne and helps the skin to recover more quickly.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to an acne-removing composition and application thereof in cosmetics.
Background
Acne is also called as acne and is a chronic inflammation of hair follicle sebaceous glands caused by the blockage of hair follicles and sebaceous glands and the abnormal outflow of sebum, and the main occurring parts are areas with vigorous sebum secretion, such as faces, chest, back and the like; the main causes of the inflammation include excessive androgen secretion, abnormal follicular sebaceous gland duct keratosis, massive propionibacterium acnes propagation, perifollicular inflammatory reaction and the like.
The current methods for treating acne are mainly divided into drug therapy and physical and chemical therapy. The drug therapy mainly comprises tretinoin, antibiotics and hormones, but the components have high irritation, more side effects, limited application range, long treatment course, easy generation of drug resistance of thalli, difficult control of drug dosage and poor safety. More importantly, the practicability of allergic skin to some medicines is poor, so that the allergic phenomenon of a patient can be caused, and certain side effects are brought; the physical and chemical treatments mainly include photodynamic, red and blue light, laser and photon treatments, chemical exfoliation treatments, and the like. The physical and chemical treatment has the disadvantages of complicated operation, high price, poor patient compliance and difficult popularization.
Chinese patent application CN106924169A discloses a honey acne-removing composition and a preparation method thereof, the acne-removing composition comprises honey, purslane herb extracting solution, wallflower extracting solution, hollyhock flower extracting solution and yogurt, the problems of propionibacterium acnes proliferation and inflammation are solved, the effects of bacteriostasis and inflammation diminishing are achieved, but the problems of sebum hypersecretion and follicular keratosis are lacked to be solved.
Chinese patent application CN105012479B discloses an acne removing composition and an acne removing cream, wherein the acne removing composition comprises shea butter, a phellodendron extract, a black willow bark extract, a purslane extract, a perilla extract, a centella asiatica extract and a mung bean extract, and a good acne removing effect is obtained through the combined action of various extracts, but the active ingredients are complex in components and high in production cost.
Disclosure of Invention
Based on the above, there is a need to provide an acne-removing composition and its application in cosmetics, which address the problems in the prior art.
An acne-removing composition comprises, by weight, 5-15 parts of yeast/zinc fermentation product, 0.5-5 parts of papain, 1-5 parts of tetrahydro-methyl pyrimidine carboxylic acid, 1-10 parts of dipotassium glycyrrhizinate, 0.1-1 part of O-cymene-5-alcohol, 0.5-5 parts of centella extract and 0.1-5 parts of allantoin.
In one embodiment, the feed comprises 2 to 6 parts by weight of yeast/zinc fermentation product, 2 to 3 parts by weight of papain, 1 to 2 parts by weight of tetrahydro-methyl pyrimidine carboxylic acid, 4 to 6 parts by weight of dipotassium glycyrrhizinate, 0.1 to 0.5 part by weight of O-cymene-5-alcohol, 0.5 to 1 part by weight of centella asiatica extract and 2 to 5 parts by weight of allantoin.
An application of acne-removing composition in cosmetics is provided.
In one embodiment, the acne removing composition is added into the cosmetic in an amount of 1-10 parts.
In one embodiment, the skin care cream further comprises 1-15 parts of polyol, 0.1-0.5 part of water-soluble polymer, 0.05-0.1 part of chelating agent, 0.2-1 part of preservative, 0.1-0.8 part of pH regulator, 0-4 parts of emulsifier, 0-15 parts of emollient oil, 0-5 parts of amino acid and the balance of water.
In one embodiment, the water-soluble polymer is one or more of xanthan gum, carbomer U20 and hydroxyethyl cellulose;
the polyalcohol is one or more of butanediol, glycerol, propylene glycol and 1,2-hexanediol.
In one embodiment, the emulsifier is one or more of ceteareth-6, ceteareth-25, oleth-5, oleth-10;
the chelating agent is EDTA-2Na.
In one embodiment, the emollient oil is one or more of hydrogenated polyisobutene, hydrogenated polyisodecene, dioctyl malate, polydimethylsiloxane, cetearyl alcohol, cetyl alcohol, stearyl alcohol, and behenyl alcohol.
In one embodiment, the amino acid is one or more of lysine, histidine, arginine, aspartic acid, threonine, serine, glutamic acid, proline.
In one embodiment, the preservative is one or more of phenoxyethanol and methylparaben;
the pH regulator is one or more of sodium hydroxide, triethanolamine, arginine, citric acid and sodium citrate.
In the invention, the yeast/zinc fermentation product is prepared by utilizing the enrichment capacity of saccharomyces cerevisiae on zinc in the growth and metabolism process and then extracting and refining the zinc by a modern biological enzymolysis technology, can effectively repair damaged cells of the skin and restore the elasticity of the skin, and is safe and mild; the papain adopts the technology of connecting active protease to acrylic acid polymer, not only retains the activity of the enzyme, but also enables the enzyme to be slowly released to the surface of the horny layer, can effectively improve the skin and promote the metabolism of the skin.
The acne-removing composition is water-soluble, and has the effects of inhibiting bacteria, diminishing inflammation, removing cutin and repairing skin barrier through a reasonable formula. In addition, when the acne cream is applied to cosmetics such as cream, essence, emulsion or gel, grease can be effectively balanced, acne can be effectively inhibited comprehensively, the acne removing effect is remarkable, and the acne cream is safe and mild, is beneficial to repairing the skin after acne and helps the skin to recover more quickly.
Detailed Description
The present invention will be described in detail with reference to the following embodiments in order to make the above objects, features and advantages of the present invention more comprehensible. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein, as those skilled in the art will recognize without departing from the spirit and scope of the present invention.
The term "prepared from …" as used herein is synonymous with "comprising". The terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.
When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when a range of "1 to 5" is disclosed, the described range should be interpreted to include the ranges "1 to 4", "1 to 3", "1 to 2 and 4 to 5", "1 to 3 and 5", and the like. When a range of values is described herein, unless otherwise specified, the range is intended to include the endpoints thereof, and all integers and fractions within the range.
In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are intended to have no limitation on the number (i.e., number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the stated number clearly indicates that the singular form is intended.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
An acne-removing composition comprises, by weight, 1-5 parts of yeast/zinc fermentation product, 0.1-5 parts of papain, 1-15 parts of tetrahydro-methyl pyrimidine carboxylic acid, 1-10 parts of dipotassium glycyrrhizinate, 0.1-1 part of O-cymene-5-alcohol, 0.5-10 parts of centella extract and 0.1-5 parts of allantoin.
Further, the specific raw material components and contents of the acne-removing composition are shown in table 1:
the above examples A1 to A4 are respectively applied to cosmetics, wherein the addition amount of the acne-removing composition in the cosmetics is 1 to 10 parts; in addition, the cosmetic also comprises 1 to 15 parts of polyhydric alcohol, 0.1 to 0.5 part of water-soluble polymer, 0.05 to 0.1 part of chelating agent, 0.2 to 1 part of preservative, 0.1 to 0.8 part of pH regulator, 0 to 4 parts of emulsifier, 0 to 15 parts of emollient oil, 0 to 5 parts of amino acid and the balance of water.
More specifically, the acne-removing composition is applied to acne-removing essence, and the specific raw material components and contents of the acne-removing essence are shown in table 2:
the above examples B1 to B4 were tested according to the following test methods and test results:
1) Stability test
The acne removing essence obtained in the embodiments B1 to B4 are respectively filled in bottles and then are respectively placed for 1 month under the conditions of 48 ℃, 15 ℃, 25 ℃ and 15 ℃ to 48 ℃ (4 cold and hot cycles); after 1 month investigation, the 4 acne removing essences have no obvious abnormality, which indicates that the acne removing essences have good stability.
2) Safety and adverse reaction evaluation
Testing population: patients with visible acne had 120, 30 patients each.
The test method comprises the following steps: the anti-acne essence prepared in the corresponding embodiment is respectively and uniformly coated on acne once in the morning and at night, the anti-acne essence is continuously used for 28 days, in the test process, a professional dermatologist inquires whether the tested subject has symptoms of dryness, greasiness, desquamation, redness, stabbing pain and the like in the process of using the essence to be tested, and the condition that whether the face has phenomena of rash, redness and desquamation is observed and recorded.
Wherein the adverse reaction scoring criteria are shown in table 3:
no adverse reactions occurred during the trial by the subjects as tested.
3) Evaluation of improvement of acne lesion symptom
Testing the population: patients with visible acne had 120, 30 patients each.
The test method comprises the following steps: the anti-acne essence prepared in the corresponding embodiment is respectively and uniformly coated on acne once in the morning and at night and continuously used for 28 days, a dermatologist evaluates the facial acne skin damage condition of a subject in a photo before and after the subject uses the product, the improvement of the skin damage symptoms of the subject before and after use is scored through an ISGA scale, the ISGA score before and after use is compared, the anti-acne effect of the product is reflected, and the percentage of skin damage reduction is calculated.
Wherein, percent skin damage reduction = (pre-product ISGA score-post-product ISGA score/pre-product ISGA score x 100%.
The specific test results are shown in table 4:
as can be seen from table 4, the skin lesion symptoms are reduced relative to the initial value (D0) in the test period, and have significant differences relative to the initial value, which indicates that the anti-acne essence has a certain anti-acne effect.
4) Evaluation of area improvement of Individual acne lesions
Testing the population: patients with visible acne had 120, 30 patients each.
The test method comprises the following steps: the anti-acne essence prepared according to the embodiment is respectively and uniformly coated on acne once in the morning and at night, the anti-acne essence is continuously used for 28 days, the area ratio of a single acne skin lesion in an AOI selected area can be calculated through a red area Image shot by a VISIA7 skin detector and spot analysis in an Image Pro Plus software skin comprehensive analysis module, and the anti-acne efficacy of the product can be reflected by comparing the change of the area ratio of the single acne skin lesion before and after use.
Wherein, the area percentage reduction rate of the acne skin lesion = (the area percentage of the acne before using the product-the area percentage of the acne after using the product)/the area percentage of the acne before using the product is multiplied by 100%.
The specific test results are shown in table 5:
as can be seen from table 5, the area ratio of the single acne skin lesion is reduced relative to the initial value (D0) in the test period, and has significant difference relative to the initial value, which indicates that the anti-acne essence has a certain anti-acne effect.
5) Color of individual acne lesions a * Evaluation of improvement
Testing the population: there were 120 patients with visible acne, 30 patients each.
The test method comprises the following steps: respectively and uniformly coating the acne-removing essence prepared by the corresponding groups on acne once in the morning and at night, continuously using for 28 days, carrying out color analysis in an Image Pro Plus software skin comprehensive analysis module on a red area Image shot by a VISIA7 skin detector to calculate the color ratio of a single acne skin lesion in an AOI selected area, wherein the software adopts a three-primary color stimulation value (L) determined by the International Commission on illumination * 、a * 、b * ) Skin color was quantified. In addition, at L * 、a * 、b * In chromaticity, a * The greater the valueThe larger the color is toward red, the smaller the color is toward green. By comparing the color of individual acne lesions a before and after application * The change of the value can reflect the acne removing efficacy of the product.
Wherein the acne skin lesion a * Value reduction rate = (acne a before use of product) * Value-acne a after use of the product * Value)/acne a before use of the product * The value is 100%.
The specific test results are shown in table 6:
as can be seen from Table 6, a single acne skin a was observed during the test period * The values are all reduced relative to the initial value (D0) and have significant difference relative to the initial value, which indicates that the acne-removing essence has certain acne-removing effect.
The acne-removing composition has the effects of inhibiting bacteria, diminishing inflammation, removing cutin and repairing skin barriers through a reasonable formula. In addition, when the acne cream is applied to cosmetics such as cream, essence, emulsion or gel, grease can be effectively balanced, acne can be effectively inhibited comprehensively, the acne removing effect is remarkable, and the acne cream is safe and mild, is beneficial to repairing the skin after acne and helps the skin to recover more quickly.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that various changes and modifications can be made by those skilled in the art without departing from the spirit of the invention, and these changes and modifications are all within the scope of the invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
1. An acne-removing composition is characterized by comprising, by weight, 5-15 parts of yeast/zinc fermentation product, 0.5-5 parts of papain, 1-5 parts of tetrahydro-methyl pyrimidine carboxylic acid, 1-10 parts of dipotassium glycyrrhizinate, 0.1-1 part of O-cymene-5-alcohol, 0.5-5 parts of centella extract and 0.1-5 parts of allantoin.
2. The acne removing composition according to claim 1, which comprises 2 to 6 parts by weight of yeast/zinc fermentation product, 2 to 3 parts by weight of papain, 1 to 2 parts by weight of tetrahydromethylpyrimidine carboxylic acid, 4 to 6 parts by weight of dipotassium glycyrrhizinate, 0.1 to 0.5 part by weight of O-cymene-5-ol, 0.5 to 1 part by weight of centella asiatica extract, and 2 to 5 parts by weight of allantoin.
3. Use of the acne-removing composition according to claim 1 or 2 in cosmetics.
4. The application of the acne-removing composition in cosmetics according to claim 3, wherein the acne-removing composition is added in the cosmetics in an amount of 1-10 parts.
5. The use according to claim 4, further comprising 1 to 15 parts of polyol, 0.1 to 0.5 part of water-soluble polymer, 0.05 to 0.1 part of chelating agent, 0.2 to 1 part of preservative, 0.1 to 0.8 part of pH regulator, 0 to 4 parts of emulsifier, 0 to 15 parts of emollient oil, 0 to 5 parts of amino acid and the balance of water.
6. The use according to claim 5, wherein the water soluble polymer is one or more of xanthan gum, carbomer U20, hydroxyethyl cellulose;
the polyalcohol is one or more of butanediol, glycerol, propylene glycol and 1,2-hexanediol.
7. Use according to claim 5, wherein the emulsifier is one or more of ceteareth-6, ceteareth-25, oleth-5, oleth-10;
the chelating agent is EDTA-2Na.
8. Use according to claim 5, wherein the emollient fat is one or more of hydrogenated polyisobutene, hydrogenated polyisodecene, dioctyl malate, dimethicone, cetearyl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol.
9. The use according to claim 5, wherein the amino acid is one or more of lysine, histidine, arginine, aspartic acid, threonine, serine, glutamic acid, proline.
10. The use of claim 5, wherein the preservative is one or more of phenoxyethanol, methylparaben;
the pH regulator is one or more of sodium hydroxide, triethanolamine, arginine, citric acid and sodium citrate.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN117679344A (en) * | 2023-12-19 | 2024-03-12 | 广州凡岛网络科技有限公司 | Anti-aging repairing composition and preparation method and application thereof |
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| CN110075046A (en) * | 2019-05-29 | 2019-08-02 | 广州睿晞生化科技有限公司 | It is a kind of can the light trace of Eradicates acne composition |
| CN114712283A (en) * | 2022-04-12 | 2022-07-08 | 北京至乐界生物科技有限公司 | Oil-control acne-clearing composition and application thereof in skin care products |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110075046A (en) * | 2019-05-29 | 2019-08-02 | 广州睿晞生化科技有限公司 | It is a kind of can the light trace of Eradicates acne composition |
| CN114712283A (en) * | 2022-04-12 | 2022-07-08 | 北京至乐界生物科技有限公司 | Oil-control acne-clearing composition and application thereof in skin care products |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN117679344A (en) * | 2023-12-19 | 2024-03-12 | 广州凡岛网络科技有限公司 | Anti-aging repairing composition and preparation method and application thereof |
| CN117679344B (en) * | 2023-12-19 | 2024-05-24 | 广州凡岛网络科技有限公司 | Anti-aging repairing composition and preparation method and application thereof |
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