CN114848520B - Whitening and repairing composition and application thereof - Google Patents
Whitening and repairing composition and application thereof Download PDFInfo
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- CN114848520B CN114848520B CN202210700234.1A CN202210700234A CN114848520B CN 114848520 B CN114848520 B CN 114848520B CN 202210700234 A CN202210700234 A CN 202210700234A CN 114848520 B CN114848520 B CN 114848520B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention discloses a whitening and repairing composition and application thereof, and relates to the technical field of cosmetics, wherein the whitening and repairing composition comprises the following components in percentage by mass: 0.5-4% of nicotinamide, 0.3-3% of tranexamic acid, 0.05-2% of VC ethyl ether, 0.03-0.5% of ceramide NP and 0.07-0.6% of sodium hyaluronate. The sodium hyaluronate comprises macromolecular sodium hyaluronate, low molecular sodium hyaluronate and hydrolyzed sodium hyaluronate. The whitening and repairing composition has the effects of whitening and repairing at the same time, and mutually synergistic, and three molecular weight sodium hyaluronate are matched with ceramide NP to strengthen skin barrier and reduce water loss. The barrier is repaired, so that the metabolism capability of the skin is improved, and the skin color is even and bright. The whitening component can prevent melanin from appearing on the stratum corneum, uniformly lighten the skin, and has a certain auxiliary effect on repairing skin barriers. Therefore, the composition is suitable for sensitive muscles and has the effects of whitening and repairing skin.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a whitening and repairing composition and application thereof.
Background
Asian women always use whitening as beauty, people's pursuit of whitening is extremely remarkable, but the damage of whitening products to skin is always present, from lead, mercury and hydroquinone to hormonal face, so that sensitive muscles and fragile muscles caused by acid brushing, excessive use of cosmetics and wrong selection of cosmetics at present cause people to worry about the heart of the whitening products, and people do not want to give up, because fair, even and transparent skin is a well-known pursuit of women.
Several approaches are needed for the external-applied whitening skin care product to achieve the whitening effect, namely, the tyrosinase activity is inhibited, the activation of melanocytes is controlled from the source, and the melanin production is reduced; secondly, inhibiting melanin from reaching the stratum corneum, transferring the melanin and preventing the melanin from being displayed on the stratum corneum; finally, the metabolism speed of the skin is increased, and melanin produced by melanocytes is gradually transferred to the horny layer along with the metabolism of the skin and falls off along with aged keratinocytes. Excessive cutin stripping of the whitening product is a way for consumers to see the whitening effect most quickly, but the whitening way can enable the cuticle to be continuously thinned and damaged, the resistance is weakened, allergic phenomena such as redness, acnes, stinging and the like occur, and the skin becomes sensitive muscles; meanwhile, some consumers excessively skin care, select skin care products with unqualified quality and the like, so that the skin barrier is damaged, and the skin becomes sensitive muscle and fragile muscle. Therefore, a product with whitening and repairing effects is developed, damaged skin barriers are repaired, skin tolerance is improved, and meanwhile, the product has the effects of whitening, brightening and homogenizing skin color, and is a trend of sensitive muscle consumers.
Disclosure of Invention
In order to solve the problems, the invention provides a whitening and repairing composition and application thereof, wherein the whitening and repairing composition is prepared by matching whitening components with moisturizing and repairing components, plays a synergistic interaction role, and is used for deeply moisturizing and locking water, repairing muscle bottoms, relieving, enhancing skin barrier function, improving whitening and brightening effects, and can be used for daily care of sensitive muscles and fragile muscles which require whitening effects. The method specifically comprises the following technical scheme:
in a first aspect, a whitening and repairing composition is provided, which comprises the following components in percentage by mass:
0.5-4% of nicotinamide, 0.3-3% of tranexamic acid, 0.05-2% of VC ethyl ether, 0.03-0.5% of ceramide NP and 0.07-0.6% of sodium hyaluronate.
Further, the sodium hyaluronate comprises macromolecular sodium hyaluronate, low molecular sodium hyaluronate and hydrolyzed sodium hyaluronate; the molecular weight of the macromolecular sodium hyaluronate is 100-150wDa; the molecular weight of the low molecular sodium hyaluronate is 20-40wDa; the molecular weight of the hydrolyzed sodium hyaluronate is less than 1wDa;
the mass ratio of the macromolecular sodium hyaluronate to the low-molecular sodium hyaluronate to the hydrolyzed sodium hyaluronate is 1: (0.2-1): (0.3-0.5).
Further, the whitening and repairing composition comprises the following components in percentage by mass:
1-2% of nicotinamide, 0.5-2% of tranexamic acid, 0.1-1% of VC ethyl ether, 0.05-0.3% of ceramide NP, 0.08-0.15% of macromolecular sodium hyaluronate, 0.02-0.15% of low molecular sodium hyaluronate and 0.02-0.15% of hydrolyzed sodium hyaluronate.
In a second aspect, there is provided a skin care cream comprising the whitening and repairing composition according to the first aspect, comprising the following components in percentage by mass: the whitening and repairing composition is 0.95-10.1% and the other auxiliary materials of the cosmetic are 89.9-99.05%.
Further, the skin care cream comprises the following components in percentage by mass:
2 percent of nicotinamide,
1.5 percent of tranexamic acid,
0.8 percent of VC ethyl ether,
ceramide NP 0.1%,
0.1 percent of macromolecular sodium hyaluronate,
0.05 percent of low molecular sodium hyaluronate,
0.04 percent of hydrolyzed sodium hyaluronate,
4 percent of emulsifying agent,
14% of an emollient,
9% of humectant,
0.15 percent of thickening agent,
0.6 percent of preservative,
0.05 percent of essence,
the balance of deionized water.
Further, the emulsifier is selected from one or more of polysorbate-60, sorbitan stearate, glyceryl stearate/PEG-100 stearate, potassium cetyl phosphate, PEG-20 methyl glucose sesquistearate, hydrogenated lecithin, methyl glucose sesquistearate, cetostearyl oleate/sorbitan olive oleate, PEG-8 stearate, and combinations thereof.
Further, the emollient is selected from one or more of isopropyl palmitate, caprylic/capric triglyceride, polydimethylsiloxane, myristyl alcohol myristate, hydrogenated polyisobutene, octyl polymethylsiloxane, cetostearyl alcohol, ethylhexyl palmitate, pentaerythritol tetra (ethylhexanoate), behenyl alcohol, squalane, C12-15 alcohol benzoate, and combinations thereof.
Further, the humectant is selected from one or more of glycerol polyether-26, glycerol, propylene glycol, butylene glycol, polyethylene glycol-32, dipropylene glycol, methyl propylene glycol, betaine, polyglycerol-6, PCA-sodium, trehalose, and combinations thereof.
Further, the thickener is selected from one or more of carbomer, xanthan gum, ammonium acryloyldimethyl taurate/VP copolymer, hydroxyethyl cellulose, polyacrylic acid, sodium polyacrylate, gellan gum, acrylic acid (esters) or C10-30 alkanol acrylate cross-linked polymer, polyacrylate cross-linked polymer-6 copolymer and combinations thereof; the preservative is selected from one or more of methylparaben, propylparaben, phenoxyethanol, ethylhexyl glycerol, chlorpheniramine, sodium benzoate, methylisothiazolinone and a composition thereof; the essence is one or more selected from faint scent type, flower scent type, fruit scent type, compound scent type and their composition.
In a third aspect, there is provided the use of a whitening and repairing composition according to the first aspect in a skin care product. Compared with the prior art, the invention has the beneficial effects that:
nicotinamide: also called vitamin B3, is a very stable vitamin, and many researches have found that nicotinamide has good effects on repairing skin barriers, lightening spots, whitening skin, improving skin elasticity and the like, and can enhance the efficacy on dry and sensitive muscles. It can prevent the migration of melanin from melanocyte to keratinocyte, thus preventing pigmentation and whitening and eliminating speckle. The niacinamide selected in the composition is a DSM cosmetic grade niacinamide with only minimal niacin residue, ensuring that no skin discomfort or sensitization problems are caused.
Tranexamic acid: also called tranexamic acid, can prevent melanin aggregation, alleviate pigment deposition, lighten spots, whiten skin, and make the skin show white, soft, bright and transparent perfect skin. It is mild and has no irritation. The tranexamic acid in the composition is produced by pharmaceutical factories.
VC ethyl ether: is a derivative of vitamin C which has a plurality of effects of inhibiting melanogenesis, the first effect being inhibition of tyrosinase and the second effect being inhibition of polymerization of melanin monomers in the melanogenesis pathway. Can also be used as antiinflammatory substances when applied to skin epidermis. The VC ethyl ether can enhance the phagocytic power of skin macrophages, thereby enhancing the immunity of the skin, improving the barrier function of the skin and resisting the invasion of external harmful substances.
Ceramide NP: also, ceramide 3, which itself is an essential component of our skin, is prone to dryness, tightness and fine wrinkles when the ceramide of the skin is insufficient. The ceramide has strong association molecular capability, namely, the ceramide is mutually combined to form a net shape, so that moisture in the stratum corneum is firmly locked, water is not required to run off, and the ceramide has good effects on skin moisturizing and repairing. The ceramide can also increase the thickness of the epidermis horny layer, improve the water locking capacity of the skin, help to stabilize the horny layer, lighten the sensitive phenomenon of the skin and resist the external stimulus. Impaired barrier function of dry sensitive skin is often characterized by a total ceramide reduction. Ceramide 3 in the composition is produced based on a sustainable biotechnology process, and the biotechnologically produced ceramide is completely consistent with the stereochemical configuration of naturally occurring ceramide in human skin.
Macromolecular sodium hyaluronate: the molecular weight is 100-150 ten thousand daltons, and the skin moisture is supplemented, so that a breathable hydration film is formed, the evaporation of the moisture in the skin is prevented, and the effects of water locking and moisture preservation are achieved.
Low molecular sodium hyaluronate: has molecular weight of 20-40 ten thousand daltons, and can hydrate and soften horny layer and tender skin.
Hydrolysis of sodium hyaluronate: the molecular weight is below 1 ten thousand daltons, and can quickly permeate the skin to reach the dermis layer of the skin, deeply lock water and maintain the muscle sole.
According to the analysis on the mechanism, the composition provided by the invention has the effects of whitening and repairing, and is synergistic, and three kinds of sodium hyaluronate with molecular weight selected in the composition are matched with ceramide NP, wherein the ceramide NP can firmly lock the moisture in the sodium hyaluronate, so that the skin activity is endowed, the skin elasticity is enhanced, the skin barrier is enhanced, the moisture loss is reduced, and the skin dryness is prevented. The barrier is repaired, so that the metabolism capability of the skin is improved, the skin color is uniform and the skin is bright. The selected whitening components (nicotinamide, tranexamic acid, and VC ethyl ether) in the composition can prevent melanin from appearing on the stratum corneum, and can uniformly lighten skin, and simultaneously have certain auxiliary effect on repairing skin barriers. Therefore, the composition is suitable for sensitive muscles and has the effects of whitening and repairing skin.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely, and it is apparent that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
It should be understood that the terms "comprises" and "comprising," when used in this specification and the appended claims, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof.
It is also to be understood that the terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used in this specification and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.
It should be further understood that the term "and/or" as used in the present specification and the appended claims refers to any and all possible combinations of one or more of the associated listed items, and includes such combinations.
In order to more fully understand the technical content of the present invention, the following description and description of the technical solution of the present invention will be further presented with reference to specific embodiments.
Preparation method of skin care cream (whitening repair cream)
S1, preparing raw material components according to the components and the content;
s2, putting deionized water into a water phase pot, adding glycerol, xanthan gum and methylparaben into the water phase pot, stirring and heating to 80-85 ℃, uniformly dispersing, and preserving heat for 20 minutes;
s3, adding cetostearyl oleate/sorbitan olive oleate, glycerol stearate/PEG-100 stearate, cetostearyl alcohol, polydimethylsiloxane, hydrogenated polyisobutene, pentaerythritol tetra (ethyl hexanoate) and caprylic/capric triglyceride into an oil phase pot, stirring and heating to 80-85 ℃, uniformly dissolving, and preserving heat for 20 minutes; adding ceramide NP and stirring uniformly;
s4, pre-dispersing propylene glycol, macromolecular sodium hyaluronate, low-molecular sodium hyaluronate and hydrolyzed sodium hyaluronate uniformly. Preheating an emulsifying pot to 82 ℃, pumping materials of a water phase pot and an oil phase pot into the emulsifying pot, adding the tranexamic acid, propylene glycol, macromolecular sodium hyaluronate, low molecular sodium hyaluronate and hydrolyzed sodium hyaluronate dispersion into the emulsifying pot under stirring, homogenizing for 10 minutes at 3000rpm/min, preserving heat, stirring for 15 minutes, and starting to cool;
s5, cooling to 45 ℃, adding sterilized deionized water to dissolve nicotinamide, VC ethyl ether, phenoxyethanol and essence, and uniformly stirring;
s6, cooling to 38 ℃, and discharging after the inspection is qualified.
Effect test-safety test of skin cream
The test is based on the fifth part of cosmetic safety Specification (2015 edition): human skin closed patch test.
The detection method comprises the following steps: and (5) performing patch testing. Selecting a qualified patch tester, placing about 0.020-0.025 mL of a test object into the patch tester by a closed patch test method, applying a medical adhesive tape for external use on the back of a subject, removing the test object after 24 hours, observing skin reactions after 0.5, 24 and 48 hours after removing the patch, and recording the results according to skin reaction grading standards in cosmetic safety technical Specification (2015 edition), wherein the skin reaction grading standards are shown in Table 1.
Number of test persons: 30 men, 6 men and 24 women; minimum age: 21 years of age, maximum age: 59. age of two.
TABLE 1 skin reaction grading criteria
Skin care cream effect test-skin moisture loss rate, face brightness and whiteness test
The tester: 270 healthy women with susceptible skin at 25-45 years old are randomly divided into 27 groups of 10 people each
Test area: face (left face using blank sample, right face using example 1 sample or control sample)
The testing method comprises the following steps: is applied once in the morning and evening for 4 weeks
Test instrument: CK skin tester (germany), VISIA full face analyzer (germany).
The effect index is as follows: the skin barrier is better as the percutaneous water loss rate, the face brightness L-value and the whiteness ITA degree are lower; the larger the face brightness L is, the better the effect of the product on brightening skin is; the higher the whiteness ITA degree, the better the product is for whitening skin.
Measuring the percutaneous water loss rate of the skin after 4 weeks using a CK skin tester, and the Δl value and whiteness Δita° of the change in brightness of the face before and after use using VISA; wherein Δl values, Δita° are the average of all test subjects.
Example 1
A skin care cream containing a whitening and repairing composition comprises the following components in percentage by mass: the whitening and repairing composition is 0.95-10.1% and the other auxiliary materials of the cosmetic are 89.9-99.05%.
Wherein the whitening and repairing composition in the skin cream comprises the following components: 2 percent of nicotinamide, 1.5 percent of tranexamic acid, 0.8 percent of VC ethyl ether, 0.1 percent of ceramide NP, 0.1 percent of macromolecular sodium hyaluronate, 0.05 percent of low molecular sodium hyaluronate, 0.04 percent of hydrolyzed sodium hyaluronate,
other cosmetic auxiliary materials in the skin cream comprise: glycerol 5%, propylene glycol 4%, xanthan gum 0.15%, methylparaben 0.2%, cetostearyl oleate/sorbitan oliveate 3%, glyceryl stearate/PEG-100 stearate 1%, cetostearyl alcohol 2%, polydimethylsiloxane 2%, hydrogenated polyisobutene 3%, pentaerythritol tetra (ethyl hexanoate) 2%, caprylic/capric triglyceride 5%, phenoxyethanol 0.4%, perfume compound 0.05% and the balance deionized water.
The skin care cream containing the whitening and repairing composition of the example 1 is prepared according to the mass percentage and the following steps:
s1, preparing raw material components according to the components and the content;
s2, putting deionized water into a water phase pot, adding glycerol, xanthan gum and methylparaben into the water phase pot, stirring and heating to 80-85 ℃, uniformly dispersing, and preserving heat for 20 minutes;
s3, adding cetostearyl oleate/sorbitan olive oleate, glycerol stearate/PEG-100 stearate, cetostearyl alcohol, polydimethylsiloxane, hydrogenated polyisobutene, pentaerythritol tetra (ethyl hexanoate) and caprylic/capric triglyceride into an oil phase pot, stirring and heating to 80-85 ℃, uniformly dissolving, and preserving heat for 20 minutes; adding ceramide NP and stirring uniformly;
s4, pre-dispersing propylene glycol, macromolecular sodium hyaluronate, low-molecular sodium hyaluronate and hydrolyzed sodium hyaluronate uniformly. Preheating an emulsifying pot to 82 ℃, pumping materials of a water phase pot and an oil phase pot into the emulsifying pot, adding the tranexamic acid, propylene glycol, macromolecular sodium hyaluronate, low molecular sodium hyaluronate and hydrolyzed sodium hyaluronate dispersion into the emulsifying pot under stirring, homogenizing for 10 minutes at 3000rpm/min, preserving heat, stirring for 15 minutes, and starting to cool;
s5, cooling to 45 ℃, adding sterilized deionized water to dissolve nicotinamide, VC ethyl ether, phenoxyethanol and essence, and uniformly stirring;
s6, cooling to 38 ℃, and discharging after the inspection is qualified.
Example 2
Example 2 is different from example 1 in the mass percentage of the components in the whitening and repairing composition, and the rest conditions are the same. Wherein the whitening and repairing composition of embodiment 2 comprises: 1.5% of nicotinamide, 1% of tranexamic acid, 0.5% of VC ethyl ether, 0.05% of ceramide NP, 0.05% of macromolecular sodium hyaluronate, 0.05% of low-molecular sodium hyaluronate and 0.03% of hydrolyzed sodium hyaluronate.
Example 3
Example 3 is different from example 1 in the mass percent of the components in the whitening and repairing composition, and the rest conditions are the same. Wherein the whitening and repairing composition of embodiment 3 comprises: 1% of nicotinamide, 1% of tranexamic acid, 0.2% of VC ethyl ether, 0.08% of ceramide NP, 0.1% of macromolecular sodium hyaluronate, 0.06% of low-molecular sodium hyaluronate and 0.05% of hydrolyzed sodium hyaluronate.
Blank examples
Blank examples differ from example 1 in that no whitening repair composition was included, and the remaining conditions were the same.
1. Effect of different contents of macromolecular sodium hyaluronate on skin cream effect
Comparative examples 1 to 3 differ from example 1 in the mass percent of the macromolecular sodium hyaluronate, and the remaining conditions are the same. The percutaneous water loss rate, the face brightness and the whiteness were measured in example 1 and comparative examples 1 to 3, respectively, and the measurement results were as follows:
TABLE 2 results of the percutaneous Water loss, facial Brightness, fair-ness tests of example 1, comparative examples 1-3
As can be seen from the test results in table 2, when the whitening and repairing composition was not added with macromolecular sodium hyaluronate (comparative example 1), the mass percentage of macromolecular sodium hyaluronate was less than 0.08% (comparative example 2), and the mass percentage of macromolecular sodium hyaluronate was more than 0.15% (comparative example 3), the percutaneous water loss rate was high and the face brightness and whiteness were low. Therefore, the mass percentage of the macromolecular sodium hyaluronate in the whitening and repairing composition is preferably 0.08-0.15%.
2. Effect of different contents of low molecular sodium hyaluronate on skin care cream effect
Comparative examples 4 to 6 differ from example 1 in the mass percent of sodium hyaluronate of low molecular weight, with the remaining conditions being the same. The percutaneous water loss rate, the face brightness and the whiteness were measured in example 1 and comparative examples 4 to 6, respectively, and the measurement results were as follows:
TABLE 3 results of the percutaneous Water loss, face Brightness and whitening tests of example 1, comparative examples 4-6
As can be seen from the test results in table 3, when the weight percentage of low molecular sodium hyaluronate (comparative example 4) was less than 0.02% (comparative example 5) and the weight percentage of low molecular sodium hyaluronate was more than 0.15% (comparative example 6), the skin-whitening and repairing composition had a higher rate of water loss through skin and a lower brightness and whiteness of the face. Therefore, the mass percentage of the low molecular sodium hyaluronate in the whitening and repairing composition is preferably 0.02-0.15%.
3. Based on the influence of different contents of hydrolyzed sodium hyaluronate on the effect of skin cream
Comparative examples 7 to 9 differ from example 1 in the mass percent of sodium hyaluronate hydrolyzed, and the remaining conditions are the same. The percutaneous water loss rate, the face brightness and the whiteness were measured in example 1 and comparative examples 7 to 9, respectively, and the measurement results were as follows:
TABLE 4 results of the percutaneous Water loss, facial Brightness, fair-ness tests of example 1, comparative examples 7-9
As can be seen from the test results in table 4, the whitening and repairing composition was not added with hydrolyzed molecular sodium hyaluronate (comparative example 7), the mass percentage of hydrolyzed molecular sodium hyaluronate was less than 0.02% (comparative example 8), the mass percentage of hydrolyzed molecular sodium hyaluronate was more than 0.15% (comparative example 9), the percutaneous water loss rate was high and the face brightness and whiteness were low. Therefore, the mass percentage of the low molecular sodium hyaluronate in the whitening and repairing composition is preferably 0.02-0.15%.
4. Effects of different mass ratios of macromole sodium hyaluronate, low molecular sodium hyaluronate and hydrolyzed sodium hyaluronate on skin cream effect
Comparative example 10-the difference from example 1 is the mass ratio of the large molecular sodium hyaluronate, the low molecular sodium hyaluronate and the hydrolyzed sodium hyaluronate, and the other conditions are the same. The percutaneous water loss rate, the face brightness and the whiteness were tested for example 1 and comparative example 10 respectively, and the test results were as follows:
TABLE 5 results of the percutaneous Water loss, facial Brightness, fair-ness tests of example 1, comparative examples 10-13
As can be seen from the test results in table 5, the skin whitening and repairing composition has a higher rate of percutaneous water loss and lower brightness and whiteness of the face when the mass ratio of the macromolecular sodium hyaluronate, the low molecular sodium hyaluronate and the hydrolyzed sodium hyaluronate is smaller (comparative example 10) or the mass ratio of the macromolecular sodium hyaluronate, the low molecular sodium hyaluronate and the hydrolyzed sodium hyaluronate is larger (comparative example 11). The skin whitening and repairing composition has the advantages that the skin whitening and repairing composition has higher percutaneous water loss rate and lower brightness and whiteness of the face when the mass ratio of macromolecular sodium hyaluronate, low-molecular sodium hyaluronate and hydrolyzed sodium hyaluronate is smaller (comparative example 12) or the mass ratio of macromolecular sodium hyaluronate, low-molecular sodium hyaluronate and hydrolyzed sodium hyaluronate is larger (comparative example 13). Therefore, the mass ratio of the macromolecular sodium hyaluronate, the low molecular sodium hyaluronate and the hydrolyzed sodium hyaluronate in the whitening and repairing composition is preferably 1: (0.2-1): (0.3-0.5).
5. Effect of different contents of sodium hyaluronate on skin cream effect
Comparative examples 14 to 18 differ from example 1 in the mass percent of sodium hyaluronate, with the remaining conditions being the same. The percutaneous water loss rate, face brightness and whiteness were measured for example 1 and comparative examples 14 to 18, respectively, and the measurement results were as follows:
TABLE 6 results of the percutaneous Water loss, facial Brightness, fair-ness tests of example 1, comparative examples 14-18
As can be seen from the test results of table 6, when sodium hyaluronate (comparative example 14) or sodium hyaluronate, which does not contain macromolecular sodium hyaluronate and low molecular sodium hyaluronate (comparative example 15) or sodium hyaluronate, which does not contain low molecular sodium hyaluronate and hydrolyzed molecular sodium hyaluronate (comparative example 16), was added to the whitening and repairing composition, the percutaneous water loss rate was high and the face brightness and whiteness were low. In addition, the effect of the lack of three components in sodium hyaluronate is higher than the lack of two components in percutaneous water loss rate, and the brightness and whiteness of the face are lower. The whitening and repairing composition has the advantages that the mass percentage of sodium hyaluronate is lower than 0.07 percent (comparative example 17), the mass percentage of sodium hyaluronate is higher than 0.6 percent (comparative example 18), the percutaneous water loss rate is higher, and the brightness and whiteness of the face are lower. Therefore, the mass percentage of the sodium hyaluronate in the whitening and repairing composition is preferably 0.07-0.6%.
6. Effect of different ceramide content on skin cream effect
Comparative examples 19 to 21 differ from example 1 in the mass percent of ceramide, with the remaining conditions being the same. The percutaneous water loss rate, face brightness and whiteness were measured for example 1 and comparative examples 19 to 21, respectively, and the measurement results were as follows:
TABLE 7 results of the percutaneous Water loss, facial Brightness, fair-ness tests of example 1, comparative examples 19-21
As is clear from the test results shown in Table 7, the whitening and repairing composition was not added with ceramide (comparative example 19), the mass percentage of ceramide was less than 0.03% (comparative example 20), the mass percentage of ceramide was more than 0.5% (comparative example 21), the percutaneous water loss rate was high and the face brightness and whiteness were low. Therefore, the mass percentage of the ceramide in the whitening and repairing composition is preferably 0.03-0.5%.
7. Effect of combination action of ceramide and sodium hyaluronate on skin cream effect
Comparative example 22 differs from example 1 in that ceramide and sodium hyaluronate are absent, and the remaining conditions are the same. Comparative example 14 was different from example 1 in that sodium hyaluronate was not contained, the other conditions were the same, comparative example 19 was different from example 1 in that ceramide was not contained, and the other conditions were the same. The percutaneous water loss rate, face brightness and whiteness were measured for example 1, comparative example 22, comparative example 14 and comparative example 19, respectively, and the measurement results were as follows:
TABLE 8 results of the percutaneous Water loss, facial Brightness, fair-ness tests for example 1, comparative example 22, comparative example 14, comparative example 19
From the test results of table 8, it is seen that the effects of the percutaneous water loss rate, the facial brightness and the whiteness of the two kinds of components lacking sodium hyaluronate and ceramide in the whitening and repairing composition are inferior to those of the single kind of components lacking sodium hyaluronate and ceramide.
8. Based on the effect of the combination of nicotinamide, tranexamic acid and VC ethyl ether on the effect of skin cream
Comparative example 23 differs from example 1 in that it does not contain nicotinamide, the remaining conditions being the same. Comparative example 24 differs from example 1 in that it does not contain tranexamic acid, and the other conditions are the same. Comparative example 25 differs from example 1 in that nicotinamide and tranexamic acid are absent, and the remaining conditions are the same. Comparative example 26 differs from example 1 in that it does not contain nicotinamide, tranexamic acid and VC ethyl ether, with the remaining conditions being the same. The percutaneous water loss rate, face brightness and whiteness were measured for example 1 and comparative examples 23 to 16, respectively, and the measurement results were as follows:
TABLE 9 results of the percutaneous Water loss, face Brightness and whiteness tests of example 1, comparative examples 23 to 26
From the test results in table 9, it can be seen that the effects of percutaneous loss of water, facial brightness and whiteness of the various components of niacinamide, tranexamic acid and VC ethyl ether are less effective in the whitening and repairing composition than the effects of the single components of niacinamide, tranexamic acid and VC ethyl ether.
9. Comparison with the effects of blank examples
Blank examples differ from example 1 in that the conditions remaining without the whitening repair composition are the same. Safety tests were performed on examples 1-3 and blank examples, and the test results are shown in Table 10:
TABLE 10 safety test results for examples 1-3 and blank
| Examples/blanksExample(s) | Test results |
| Example 1 | All are negative reactions |
| Example 2 | All are negative reactions |
| Example 3 | All are negative reactions |
| Blank examples | Two cases of suspicious reactions |
As can be seen from the test results in Table 10, among 30 persons, the test results in examples 1 to 3 showed positive reactions in 0 cases, and the test results in the blank cases showed suspicious reactions in 2 cases, indicating that the cream prepared by adding the whitening and repairing composition of the present application was milder.
The test results show that the skin cream prepared from the whitening and repairing composition of the embodiments 1-3 has whitening and repairing effects and is synergistic. The skin cream which lacks one or more components of nicotinamide, tranexamic acid, VC ethyl ether, ceramide NP, macromolecular sodium hyaluronate, low molecular sodium hyaluronate and hydrolyzed sodium hyaluronate is difficult to repair damaged skin barriers, improves skin tolerance, and has the ideal effects of whitening, brightening and homogenizing skin colors.
The whitening and repairing composition provided by the invention utilizes three sodium hyaluronate and ceramide NP with different molecular weights to repair skin barriers, reduce water loss and relieve skin dryness. The barrier is repaired, so that the metabolism capability of the skin is improved, the skin color is uniform and the skin is bright. Meanwhile, the invention utilizes three whitening components of nicotinamide, tranexamic acid and VC ethyl ether to prevent melanin from appearing on the stratum corneum, and uniformly lightens the skin, and has certain auxiliary effect on repairing skin barriers. Therefore, the composition is suitable for sensitive muscles and has the effects of whitening and repairing skin. The invention utilizes the mutual synergistic effect of the repairing barrier component and the whitening component to repair the skin barrier, lighten and whiten the skin evenly, and realizes better skin whitening and repairing effects.
In summary, the synergistic effect of the different components in examples 1-3 realizes repair of damaged skin barrier, improves skin tolerance, and has effects of whitening, brightening and evening skin color.
While the invention has been described with reference to certain preferred embodiments, it will be understood by those skilled in the art that various changes and substitutions of equivalents may be made and equivalents will be apparent to those skilled in the art without departing from the scope of the invention. Therefore, the protection scope of the invention is subject to the protection scope of the claims.
Claims (3)
1. The skin care cream containing the whitening and repairing composition is characterized by comprising the following components in percentage by mass:
2 percent of nicotinamide,
1.5 percent of tranexamic acid,
0.8 percent of VC ethyl ether,
ceramide NP 0.1%,
0.1 percent of macromolecular sodium hyaluronate,
0.05 percent of low molecular sodium hyaluronate,
0.04 percent of hydrolyzed sodium hyaluronate,
4 percent of emulsifying agent,
14% of an emollient,
9% of humectant,
0.15 percent of thickening agent,
0.6 percent of preservative,
0.05 percent of essence,
the balance of deionized water;
the molecular weight of the macromolecular sodium hyaluronate is 100-150wDa; the molecular weight of the low molecular sodium hyaluronate is 20-40wDa; the molecular weight of the hydrolyzed sodium hyaluronate is less than 1wDa;
wherein, the emollient consists of cetostearyl alcohol 2%, polydimethylsiloxane 2%, hydrogenated polyisobutene 3%, pentaerythritol tetra (ethyl caproic acid) ester 2% and caprylic/capric triglyceride 5%; the humectant consists of 5% of glycerin and 4% of propylene glycol.
2. The skin cream of claim 1 wherein the emulsifier is selected from one or more of polysorbate-60, sorbitan stearate, glyceryl stearate/PEG-100 stearate, potassium cetyl phosphate, PEG-20 methyl glucurolactone, hydrogenated lecithin, methyl glucurolactone, cetostearyl oleate/sorbitan olivate, PEG-8 stearate, and combinations thereof.
3. The skin care cream comprising a whitening and repairing composition according to claim 1, wherein the thickener is selected from one or more of carbomers, xanthan gum, ammonium acryloyldimethyl taurate/VP copolymer, hydroxyethyl cellulose, polyacrylic acid, sodium polyacrylate, gellan gum, acrylic acid (esters) type/C10-30 alkanol acrylate cross-linked polymer, polyacrylate cross-linked polymer-6 copolymer and combinations thereof; the preservative is selected from one or more of methylparaben, propylparaben, phenoxyethanol, ethylhexyl glycerol, chlorpheniramine, sodium benzoate, methylisothiazolinone and a composition thereof; the essence is one or more selected from faint scent type, flower scent type, fruit scent type, compound scent type and their composition.
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| CN116115528B (en) * | 2022-12-14 | 2024-10-15 | 广州市科能化妆品科研有限公司 | Composition for relieving, repairing and moisturizing as well as application and preparation method thereof |
| CN116473869A (en) * | 2023-03-30 | 2023-07-25 | 上海伯通伟达生物科技开发有限公司 | Composition for moisturizing skin and preparation method thereof |
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