CN114732743A - Moisturizing and anti-wrinkle face cream with lamellar liquid crystal structure and preparation method thereof - Google Patents
Moisturizing and anti-wrinkle face cream with lamellar liquid crystal structure and preparation method thereof Download PDFInfo
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- CN114732743A CN114732743A CN202210155833.XA CN202210155833A CN114732743A CN 114732743 A CN114732743 A CN 114732743A CN 202210155833 A CN202210155833 A CN 202210155833A CN 114732743 A CN114732743 A CN 114732743A
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- Prior art keywords
- liquid crystal
- moisturizing
- cream
- wrinkle
- crystal structure
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- 239000004973 liquid crystal related substance Substances 0.000 title claims abstract description 52
- 239000006071 cream Substances 0.000 title claims abstract description 48
- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 36
- 230000001153 anti-wrinkle effect Effects 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- -1 hydroxy pinacolone retinoic acid ester Chemical class 0.000 claims abstract description 34
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims abstract description 30
- 239000003921 oil Substances 0.000 claims abstract description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 15
- 229960003471 retinol Drugs 0.000 claims abstract description 15
- 235000020944 retinol Nutrition 0.000 claims abstract description 15
- 239000011607 retinol Substances 0.000 claims abstract description 15
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 13
- 229960001631 carbomer Drugs 0.000 claims abstract description 13
- 239000003974 emollient agent Substances 0.000 claims abstract description 12
- 239000003906 humectant Substances 0.000 claims abstract description 12
- 229930002330 retinoic acid Natural products 0.000 claims abstract description 10
- 229960001727 tretinoin Drugs 0.000 claims abstract description 10
- 239000003755 preservative agent Substances 0.000 claims abstract description 9
- 230000002335 preservative effect Effects 0.000 claims abstract description 9
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- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 claims description 22
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- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 21
- 229930182478 glucoside Natural products 0.000 claims description 20
- 235000019198 oils Nutrition 0.000 claims description 20
- 238000003756 stirring Methods 0.000 claims description 20
- 238000002156 mixing Methods 0.000 claims description 15
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 14
- 230000001804 emulsifying effect Effects 0.000 claims description 13
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 12
- 238000005303 weighing Methods 0.000 claims description 12
- 229960000735 docosanol Drugs 0.000 claims description 11
- 150000008131 glucosides Chemical class 0.000 claims description 11
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 10
- 235000011187 glycerol Nutrition 0.000 claims description 10
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 9
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 9
- 230000037303 wrinkles Effects 0.000 claims description 9
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 8
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 8
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims description 8
- 241001135917 Vitellaria paradoxa Species 0.000 claims description 8
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 8
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 8
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 claims description 8
- 229960005323 phenoxyethanol Drugs 0.000 claims description 8
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 8
- 229940057910 shea butter Drugs 0.000 claims description 8
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 8
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims description 7
- 229940032094 squalane Drugs 0.000 claims description 7
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 6
- 229940081733 cetearyl alcohol Drugs 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 6
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 6
- 244000027321 Lychnis chalcedonica Species 0.000 claims description 5
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 4
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 4
- 238000007599 discharging Methods 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 239000004475 Arginine Substances 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 3
- 235000021314 Palmitic acid Nutrition 0.000 claims description 3
- 235000021355 Stearic acid Nutrition 0.000 claims description 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 3
- 229960000541 cetyl alcohol Drugs 0.000 claims description 3
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 claims description 3
- 238000004945 emulsification Methods 0.000 claims description 3
- 235000019441 ethanol Nutrition 0.000 claims description 3
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims description 3
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 3
- 239000011570 nicotinamide Substances 0.000 claims description 3
- 229960003966 nicotinamide Drugs 0.000 claims description 3
- 235000005152 nicotinamide Nutrition 0.000 claims description 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 3
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 3
- 238000004806 packaging method and process Methods 0.000 claims description 3
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- 150000003077 polyols Chemical class 0.000 claims description 3
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- 229940012831 stearyl alcohol Drugs 0.000 claims description 3
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 claims description 2
- 229940035437 1,3-propanediol Drugs 0.000 claims description 2
- 239000010487 meadowfoam seed oil Substances 0.000 claims description 2
- 229920000166 polytrimethylene carbonate Polymers 0.000 claims description 2
- 229940105990 diglycerin Drugs 0.000 claims 1
- 229960005150 glycerol Drugs 0.000 claims 1
- 239000004519 grease Substances 0.000 abstract description 7
- 239000007788 liquid Substances 0.000 abstract description 4
- 239000007787 solid Substances 0.000 abstract description 4
- 230000014759 maintenance of location Effects 0.000 abstract description 3
- 230000037394 skin elasticity Effects 0.000 abstract description 3
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- LODWEXDBRZBADB-XEVVZDEMSA-N (2s)-6-amino-2-[[(2s)-2-[[(2s)-6-amino-2-(hexadecanoylamino)hexanoyl]amino]-3-methylbutanoyl]amino]hexanoic acid Chemical compound CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(O)=O LODWEXDBRZBADB-XEVVZDEMSA-N 0.000 abstract 1
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- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 abstract 1
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- 229940010747 sodium hyaluronate Drugs 0.000 abstract 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 abstract 1
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0295—Liquid crystals
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/03—Liquid compositions with two or more distinct layers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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Abstract
The invention discloses a moisturizing and anti-wrinkle face cream with a layered liquid crystal structure and a preparation method thereof, and relates to the field of skin care products, wherein the face cream comprises the following raw material components: water, a polyalcohol humectant, an emulsifier, an oil emollient, retinol, hydroxy pinacolone retinoic acid ester, carbomer, a pH regulator, nicotinamide, palmitoyl tripeptide-5, an undaria pinnatifida extract, hydrolyzed vegetable protein, saccharide isomerate, hydrolyzed sodium hyaluronate and a preservative. The invention has the advantages that: according to the invention, the natural liquid crystal emulsifier is compounded with specific solid grease, liquid grease, water and carbomer to prepare the moisturizing and anti-wrinkle cream containing lamellar liquid crystal, and the moisturizing and anti-wrinkle cream has the functions of long-acting moisture retention and improvement of skin roughness, skin elasticity and fine lines.
Description
Technical Field
The invention relates to the field of skin care products, in particular to a moisturizing and anti-wrinkle face cream with a lamellar liquid crystal structure and a preparation method thereof.
Background
The skin is an important organ of the human body, has a complex tissue structure, is closely connected with other organs of the human body, plays a role of a barrier and protects the human body from external stimulation and injury. In recent years, with continuous innovation of skin care products and pharmaceutical technology and improvement of living standard of people, natural, safe, environment-friendly and functional skin care products are more and more popular with consumers. Therefore, the development of the liquid crystal structure cream using the natural raw materials can not only meet the requirements of consumers on moisturizing and anti-wrinkle performance, but also bring brand-new skin care experience to the consumers.
A great deal of literature research data shows that the liquid crystal structure cream has the following advantages compared with other common creams: firstly, the formula has better stability because the liquid crystal protective layer is formed; secondly, the lamellar liquid crystal structure is similar to the structure of lipid between human skin corneocytes, so that the lamellar liquid crystal has better skin affinity; thirdly, the active ingredient can be wrapped by the lamellar liquid crystal structure, so that the stability of the active ingredient is improved, the release of the active ingredient can be slowed down, and the effect of the active ingredient is maximized; fourthly, the skin feel of the skin is excellent and not sticky.
The moisturizing and wrinkle-resisting facial cream with the lamellar liquid crystal structure is an emulsifying system different from common facial cream, wherein a liquid crystal layer can wrap retinol and hydroxy pinacolone retinoic acid ester in a formula, so that the irritation of the retinol can be reduced, the retinol and the hydroxy pinacolone retinoic acid ester can be promoted to permeate below the skin cuticle, other moisturizing components and polypeptide components are compounded, and the roughness, the skin elasticity and fine lines of the skin can be effectively improved.
Disclosure of Invention
In order to solve the technical problems, the technical scheme is that a natural liquid crystal type emulsifier is compounded with specific solid grease, liquid grease, water and carbomer to prepare the moisturizing and anti-wrinkle cream containing the lamellar liquid crystal, and the moisturizing and anti-wrinkle cream has long-acting moisturizing effect and the functions of improving skin roughness, skin elasticity and fine lines.
In order to achieve the above purposes, the technical scheme adopted by the invention is as follows:
the moisturizing and anti-wrinkle face cream with the lamellar liquid crystal structure comprises the following raw material components in percentage by weight:
preferably, the polyhydric alcohol humectant is one or more selected from glycerol, diglycerol, 1, 3-propanediol and butanediol.
Preferably, the emulsifier is selected from one or more of hydrogenated lecithin compound, PEG-20 phytosterol compound and cetearyl glucoside compound;
wherein the hydrogenated lecithin compound comprises one or more of hydrogenated lecithin, C12-16 alcohol, palmitic acid and stearic acid;
the PEG-20 phytosterol compound comprises one or more of PEG-20 phytosterol, cetyl alcohol, stearyl alcohol and behenyl alcohol;
the cetearyl glucoside compound comprises one or more of cetearyl glucoside, C12-18 alkyl glucoside, C12-20 alkyl glucoside and cetearyl alcohol.
Preferably, the oil emollient is selected from one or more of squalane, caprylic/capric triglyceride, shea butter, polydimethylsiloxane, meadowfoam seed oil and behenyl alcohol.
Preferably, the pH regulator is selected from one or more of sodium hydroxide, potassium hydroxide and arginine.
Preferably, the preservative is one or more selected from phenoxyethanol, ethylhexyl glycerol, caprylyl glycol and 1, 2 hexanediol.
Preferably, the moisturizing and anti-wrinkle face cream water interface is provided with a lamellar liquid crystal phase protection layer with a maltese cross structure.
Further, a preparation method of the moisturizing and anti-wrinkle face cream with a lamellar liquid crystal structure is provided, and comprises the following steps:
s1, weighing water, a polyol humectant and nicotinamide according to the proportion, adding into an emulsifying pot, and mixing and stirring uniformly;
s2, weighing carbomer according to the proportion, starting an emulsifying pot to homogenize slowly, scattering carbomer slowly into the pot, homogenizing for 5 minutes after the carbomer is added, confirming that the material body is uniform, and heating to 75-80 ℃;
s3, weighing a pH regulator according to the proportion, adding the pH regulator into an emulsifying pot, regulating the pH value to 6.0-7.0, stirring and homogenizing for 5 minutes, and recording the uniform material as a water phase;
s4, weighing the emulsifier and the grease emollient according to the proportion, heating to 75-80 ℃, stirring uniformly, adding retinol and hydroxy pinacolone retinoic acid ester 1 min before emulsification, and recording as oil phase;
and S5, adding the oil phase into the stirred water phase, adding other components weighed according to the proportion, and uniformly stirring to obtain the moisturizing and anti-wrinkle face cream containing the lamellar liquid crystal.
Optionally, the specific operation steps of step S5 are: adding the oil phase into the stirred water phase, stirring and homogenizing at the rotating speed of 1400-1600rpm/min, emulsifying for 5min, stirring and cooling to 40-45 ℃, adding the other components weighed according to the proportion, stirring uniformly, taking a sample, observing a liquid crystal structure containing maltese cross in the cream under the polarization condition by using a microscope, cooling to 20-25 ℃, and discharging to obtain the moisturizing and anti-wrinkle cream containing lamellar liquid crystal.
Optionally, the cream discharging method further comprises the following steps:
filling, packaging finished products, detecting the finished products and leaving the factory.
Compared with the prior art, the invention has the advantages that:
according to the invention, the moisturizing and wrinkle-resisting facial cream with lamellar liquid crystal can be obtained by compounding the natural liquid crystal emulsifier with a specific amount, the specific solid grease, the specific liquid grease, the specific water and the specific carbomer and by the preparation process of the invention. Through the preparation process, the retinol and the hydroxy pinacolone retinoic acid ester can be wrapped in a layered liquid crystal structure, so that the irritation of the retinol can be effectively reduced, the retinol and the hydroxy pinacolone retinoic acid ester can be promoted to permeate below the stratum corneum of the skin, other moisturizing components and polypeptide components are compounded, and the roughness, the elasticity and the fine lines of the skin can be effectively improved.
Drawings
FIG. 1 is a photomicrograph of a proposed cream of the present invention;
fig. 2 is a flow chart of a preparation method of the facial cream provided by the invention.
Detailed Description
The following description is presented to disclose the invention so as to enable any person skilled in the art to practice the invention. The preferred embodiments in the following description are given by way of example only, and other obvious variations will occur to those skilled in the art.
The invention provides a preparation method of a moisturizing and anti-wrinkle face cream with a lamellar liquid crystal structure, which comprises the following steps:
s1, weighing water, a polyol humectant and nicotinamide according to the proportion, adding into an emulsifying pot, and mixing and stirring uniformly;
s2, weighing carbomer according to the proportion, starting an emulsifying pot to homogenize slowly, scattering carbomer slowly into the pot, homogenizing for 5 minutes after the carbomer is added, confirming that the material body is uniform, and heating to 75-80 ℃;
s3, weighing a pH regulator according to the proportion, adding the pH regulator into an emulsifying pot, regulating the pH value to 6.0-7.0, stirring and homogenizing for 5 minutes, and recording the uniform material as a water phase;
s4, weighing the emulsifier and the oil emollient according to the proportion, heating to 75-80 ℃, uniformly stirring, adding retinol and hydroxy pinacolone retinoic acid ester 1 minute before emulsification, and recording as an oil phase;
s5, adding the oil phase into the stirred water phase, stirring and homogenizing at the rotation speed of 1400-1600rpm/min, emulsifying for 5min, stirring and cooling to 40-45 ℃, adding other components weighed according to the proportion, stirring uniformly, taking a sample, observing a liquid crystal structure containing maltese cross in the cream under the polarization condition by using a microscope, cooling to 20-25 ℃, and discharging to obtain the moisturizing and anti-wrinkle cream containing lamellar liquid crystal.
And (4) filling the discharged cream, packaging the finished product, and detecting the finished product to leave the factory.
Further provides the moisturizing and anti-wrinkle face cream with the lamellar liquid crystal structure, which is prepared based on the preparation method;
the first embodiment is as follows:
in the embodiment, the components and the weight percentages thereof are as follows:
in this embodiment: the polyhydric alcohol humectant is glycerin and butanediol, and the weight ratio of glycerin to butanediol is 7:3 in proportion;
the emulsifier is cetearyl glucoside complex, and is specifically prepared by mixing cetearyl glucoside and cetearyl alcohol according to the ratio of 3: 1;
the oil emollient is prepared by mixing squalane, caprylic/capric triglyceride, shea butter fruit resin, polydimethylsiloxane, chinaroot greenbrier seed oil and behenyl alcohol according to the proportion of 1:4:4:2:1: 2.5;
the pH regulator is sodium hydroxide;
the preservative is prepared by mixing phenoxyethanol, caprylyl glycol and 1, 2 hexanediol according to the proportion of 7:3: 10.
Example two:
in the embodiment, the components and the weight percentages thereof are as follows:
in this embodiment: the polyalcohol humectant is diglycerol;
the emulsifier is composed of hydrogenated lecithin compound and PEG-20 phytosterol compound, and specifically is composed of PEG-20 phytosterol, cetyl alcohol, stearyl alcohol, behenyl alcohol and hydrogenated lecithin according to the proportion of 4:4:5:6: 1;
the oil emollient is prepared from squalane, caprylic/capric triglyceride, shea butter, polydimethylsiloxane, chinaroot greenbrier seed oil, and behenyl alcohol according to the proportion of 1:4:4:2:1: 2.5;
the pH regulator is formed by matching sodium hydroxide and arginine;
the preservative is prepared by mixing phenoxyethanol, caprylyl glycol and 1, 2 hexanediol according to the proportion of 7:3: 10.
Example three:
in the embodiment, the components and the weight percentages thereof are as follows:
in this embodiment:
in this embodiment: the polyhydric alcohol humectant is 1, 3 propylene glycol;
the emulsifier is composed of hydrogenated lecithin compound, PEG-20 phytosterol compound whale, and wax stearyl glucoside compound, and specifically comprises PEG-20 phytosterol, C12-16 alcohol, palmitic acid, stearic acid, hydrogenated lecithin, C12-18 alkyl glucoside, and C12-20 alkyl glucoside at a ratio of 8:1:1:2:1:3: 2;
the oil emollient is prepared from squalane, caprylic/capric triglyceride, shea butter, polydimethylsiloxane, chinaroot greenbrier seed oil, and behenyl alcohol according to the proportion of 1:4:4:2:1: 2.5;
the pH regulator is potassium hydroxide;
the preservative is prepared by mixing phenoxyethanol, caprylyl glycol and 1, 2 hexanediol according to the proportion of 7:3: 10.
Comparative example one:
in this comparative example: the components and the weight percentage thereof are as follows:
in this comparative example: the polyhydric alcohol humectant is glycerin and butanediol, and the weight ratio of glycerin to butanediol is 7:3 in proportion;
the emulsifier is cetearyl glucoside complex, and is specifically prepared by mixing cetearyl glucoside and cetearyl alcohol according to the ratio of 3: 1;
the oil emollient is prepared from squalane, caprylic/capric triglyceride, shea butter, polydimethylsiloxane, chinaroot greenbrier seed oil, and behenyl alcohol according to the proportion of 1:4:4:2:1: 2.5;
the pH regulator is sodium hydroxide;
the preservative is prepared by mixing phenoxyethanol, caprylyl glycol and 1, 2 hexanediol according to the proportion of 7:3: 10.
Comparative example two:
in this comparative example: the components and the weight percentage thereof are as follows:
in this comparative example: the polyhydric alcohol humectant is glycerin and butanediol, and the weight ratio of glycerin to butanediol is 7:3 in proportion;
the emulsifier is cetearyl glucoside complex, specifically prepared by mixing cetearyl glucoside and cetearyl alcohol at a ratio of 3: 1;
the oil emollient is prepared from squalane, caprylic/capric triglyceride, shea butter, polydimethylsiloxane, chinaroot greenbrier seed oil, and behenyl alcohol according to the proportion of 1:4:4:2:1: 2.5;
the pH regulator is sodium hydroxide;
the preservative is prepared by mixing phenoxyethanol, caprylyl glycol and 1, 2 hexanediol according to the proportion of 7:3: 10.
Comparative example three:
in this comparative example: the components and the weight percentage thereof are as follows:
in this comparative example: the polyhydric alcohol humectant is glycerin and butanediol, and the weight ratio of glycerin to butanediol is 7:3 in proportion;
the emulsifier is cetearyl glucoside complex, and is specifically prepared by mixing cetearyl glucoside and cetearyl alcohol according to the ratio of 3: 1;
the oil emollient is prepared by mixing caprylic acid/capric acid triglyceride, shea butter, polydimethylsiloxane and behenyl alcohol according to the proportion of 4:4:2: 2.5;
the pH regulator is sodium hydroxide;
the preservative is prepared by mixing phenoxyethanol, caprylyl glycol and 1, 2 hexanediol according to the proportion of 7:3: 10.
And (3) performance testing:
experiment one: stability test
The test method comprises the following steps: the cream was left at 50 ℃, 40 ℃, 25 ℃, 5 ℃ and-18 ℃ for 12 weeks, and the appearance of the sample was observed under a polarizing microscope, and the results are shown in the following table:
in the system of example 1, when the potassium cetyl phosphate serving as an anionic emulsifier is compounded, the liquid crystal structure in the original system is damaged; in the system of example 1, when the highly polar oil diisostearyl malate was used in place of the oil in the formulation, the liquid crystal structure in the original system was also destroyed. In addition, the number of liquid crystal structures is reduced under high and low temperature conditions, but still within an acceptable range.
Experiment two: patch test
The test method comprises the following steps: 30 qualified test subjects are recruited, qualified test subjects are selected, a closed spot test method is adopted, about 0.020g-0.025g (solid) or 0.020mL-0.025mL (liquid) of the test subjects are placed in a spot test device, low-sensitization adhesive tapes are externally applied to the curved side of the forearm of the test subjects, the test subjects are removed after 24 hours, skin reactions are observed after 0.5 hour, 24 hour and 48 hour after removal respectively, the results are recorded according to the skin reaction grading standard in the current effective technical specification, and the results are shown in the following table:
as can be seen from the data in the table, examples 1, 2, 3 and comparative example 2 did not have any adverse reaction; while comparative examples 1 and 3 have three adverse reactions, respectively, indicating that comparative examples 1 and 3 have potential irritation risks. The possibility of causing adverse reactions in comparative examples 1 and 3 was due to retinol in the formulation; in the embodiments 1, 2 and 3, the lamellar liquid crystal structure is formed, so that the retinol is effectively wrapped, and the direct contact of the retinol with the skin is reduced.
Experiment three: short term moisture retention test
The test method comprises the following steps: the area of the test area on the curved side of the forearm of the subject was selected to be 2X 2cm2, six sites were selected on both arms (for six experimental examples), and after cleaning, the product was applied to the area to be tested. The measurement of the stratum corneum moisture content of the area to be tested was carried out using a Corneometer (skin moisture tester) at 0h, 4h and 8h before and after use, respectively. The same site was measured 5 times, and 3 averages were taken after excluding the maximum and minimum values and recorded. The values are the average of 5 subjects and the results are shown in the table below.
Parameter interpretation: the greater the stratum corneum moisture content value (CORNE), the higher the skin stratum corneum moisture content.
From the data in the above table, it can be seen that the stratum corneum water growth rate was 52% after the product of example 1 of the present application, and still remained 34.2% after 8 h. Compared with comparative examples 1 and 3, the moisture content of the skin after the product is used is obviously better than that of the comparative examples 1 and 3. It can be seen that the formula containing the lamellar liquid crystal structure has more excellent moisture retention.
Experiment four: long acting anti-wrinkle test
VISIA-CR photographs were taken and the IPP software analyzed for facial fine line area and proportion. Parameter interpretation: the smaller the wrinkle area is, the smaller the proportion is, and the better the wrinkle-resistant effect is.
The using method comprises the following steps: the subjects were divided into two groups of 15 subjects each. Using the half-face test, the first group of subjects used example 1 and comparative example 1 for the left and right faces, respectively; the second group of subjects used example 1 and comparative example 2 on both the left and right faces. The using method comprises the following steps: the face image acquisition is carried out on the subjects after 2W and 4W respectively.
As can be seen from the data in the table above, with the products of the present application example 1 and comparative example 1, the wrinkle area was reduced by 15.2% and 10.7%, respectively, after two weeks; after 4 weeks of use, the wrinkle area was reduced by 17.9% and 13.4%, respectively. Therefore, the formula containing the liquid crystal structure has better anti-wrinkle effect. The possible reason is that the hydroxy pinacolone retinoic acid ester and retinol in the formulation of example 1 are wrapped in lamellar liquid crystal, and have better permeability and thus better anti-wrinkle effect.
From the data in the table above, it can be seen that the wrinkle area was reduced by 16.0% and 10.9% after two weeks using the products of example 1 and comparative example 2 of the present application; after 4 weeks of use, the wrinkle area was reduced by 17.1% and 12.4%, respectively. Therefore, in the formula containing the liquid crystal structure, the formula containing the hydroxy pinacolone retinoic acid ester and retinol has a better anti-wrinkle effect.
In conclusion, the cream provided by the invention has a stable lamellar liquid crystal structure, and experiments show that the cream has good moisturizing and anti-wrinkle effects.
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are merely illustrative of the principles of the invention, but that various changes and modifications may be made without departing from the spirit and scope of the invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (10)
1. The moisturizing and anti-wrinkle face cream with a lamellar liquid crystal structure is characterized by comprising the following raw material components in percentage by weight:
2. the moisturizing and wrinkle-resisting cream with a lamellar liquid crystal structure according to claim 1, wherein the polyhydric alcohol humectant is one or more selected from glycerin, diglycerin, 1, 3-propanediol and butanediol.
3. The moisturizing and anti-wrinkle cream with a lamellar liquid crystal structure according to claim 1, wherein the emulsifier is selected from one or more of hydrogenated lecithin compound, PEG-20 phytosterol compound, cetearyl glucoside compound;
wherein the hydrogenated lecithin compound comprises one or more of hydrogenated lecithin, C12-16 alcohol, palmitic acid and stearic acid;
the PEG-20 phytosterol compound comprises one or more of PEG-20 phytosterol, cetyl alcohol, stearyl alcohol and behenyl alcohol;
the cetearyl glucoside complex comprises one or more of cetearyl glucoside, C12-18 alkyl glucoside, C12-20 alkyl glucoside, and cetearyl alcohol.
4. The moisturizing and anti-wrinkle face cream with a lamellar liquid crystal structure as claimed in claim 1, wherein the oil emollient is selected from one or more of squalane, caprylic/capric triglyceride, shea butter, polydimethylsiloxane, meadowfoam seed oil and behenyl alcohol.
5. The moisturizing and wrinkle-resisting cream with a layered liquid crystal structure as claimed in claim 1, wherein the pH regulator is selected from one or more of sodium hydroxide, potassium hydroxide and arginine.
6. The moisturizing and wrinkle-resisting cream with a lamellar liquid crystal structure according to claim 1, wherein the preservative is one or more selected from phenoxyethanol, caprylyl glycol and 1, 2 hexanediol.
7. The moisturizing and wrinkle-resistant cream with a lamellar liquid crystal structure according to claim 1, wherein the moisturizing and wrinkle-resistant cream has a lamellar liquid crystal phase protection layer with a maltese cross structure at the water interface.
8. A preparation method of a moisturizing and anti-wrinkle face cream with a lamellar liquid crystal structure is characterized by comprising the following steps:
s1, weighing water, a polyol humectant and nicotinamide according to the proportion, adding into an emulsifying pot, and mixing and stirring uniformly;
s2, weighing carbomer according to the proportion, starting an emulsifying pot to homogenize slowly, scattering carbomer slowly into the pot, homogenizing for 5 minutes after the carbomer is added, confirming that the material body is uniform, and heating to 75-80 ℃;
s3, weighing a pH regulator according to the proportion, adding the pH regulator into an emulsifying pot, regulating the pH value to 6.0-7.0, stirring and homogenizing for 5 minutes, and recording the uniform material as a water phase;
s4, weighing the emulsifier and the oil emollient according to the proportion, heating to 75-80 ℃, uniformly stirring, adding retinol and hydroxy pinacolone retinoic acid ester 1 minute before emulsification, and recording as an oil phase;
and S5, adding the oil phase into the stirred water phase, adding other components weighed according to the proportion, and uniformly stirring to obtain the moisturizing and anti-wrinkle face cream containing the lamellar liquid crystal.
9. The method for preparing the moisturizing and wrinkle-resistant cream with the lamellar liquid crystal structure according to claim 8, wherein the specific operation steps of the step S5 are as follows: adding the oil phase into the stirred water phase, stirring and homogenizing at the rotating speed of 1400-1600rpm/min, emulsifying for 5min, stirring and cooling to 40-45 ℃, adding the other components weighed according to the proportion, stirring uniformly, taking a sample, observing a liquid crystal structure containing maltese cross in the cream under the polarization condition by using a microscope, cooling to 20-25 ℃, and discharging to obtain the moisturizing and anti-wrinkle cream containing lamellar liquid crystal.
10. The preparation method of the moisturizing and anti-wrinkle cream with the lamellar liquid crystal structure according to claim 8, wherein the cream further comprises the following steps after the cream is discharged:
filling, packaging finished products, detecting the finished products and leaving the factory.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116059124A (en) * | 2023-03-06 | 2023-05-05 | 水羊化妆品制造有限公司 | Composition for improving gamma-aminobutyric acid irritation as well as preparation method and application thereof |
| CN117064771A (en) * | 2023-10-17 | 2023-11-17 | 清远市望莎生物科技有限公司 | Oil-in-water emulsifier and application thereof as well as daily chemical product |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110368323A (en) * | 2019-08-05 | 2019-10-25 | 广州市玉鑫化妆品有限公司 | A kind of composite skin care product and its preparation method and application containing liquid crystal emulsifier |
| CN110974742A (en) * | 2019-12-04 | 2020-04-10 | 威莱(广州)日用品有限公司 | Moisturizing and repairing hand cream with liquid crystal structure and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110368323A (en) * | 2019-08-05 | 2019-10-25 | 广州市玉鑫化妆品有限公司 | A kind of composite skin care product and its preparation method and application containing liquid crystal emulsifier |
| CN110974742A (en) * | 2019-12-04 | 2020-04-10 | 威莱(广州)日用品有限公司 | Moisturizing and repairing hand cream with liquid crystal structure and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116059124A (en) * | 2023-03-06 | 2023-05-05 | 水羊化妆品制造有限公司 | Composition for improving gamma-aminobutyric acid irritation as well as preparation method and application thereof |
| CN117064771A (en) * | 2023-10-17 | 2023-11-17 | 清远市望莎生物科技有限公司 | Oil-in-water emulsifier and application thereof as well as daily chemical product |
| CN117064771B (en) * | 2023-10-17 | 2023-12-12 | 清远市望莎生物科技有限公司 | Oil-in-water emulsifier and application thereof as well as daily chemical product |
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