CN114732743B - Moisturizing anti-wrinkle facial cream with lamellar liquid crystal structure and preparation method thereof - Google Patents
Moisturizing anti-wrinkle facial cream with lamellar liquid crystal structure and preparation method thereof Download PDFInfo
- Publication number
- CN114732743B CN114732743B CN202210155833.XA CN202210155833A CN114732743B CN 114732743 B CN114732743 B CN 114732743B CN 202210155833 A CN202210155833 A CN 202210155833A CN 114732743 B CN114732743 B CN 114732743B
- Authority
- CN
- China
- Prior art keywords
- liquid crystal
- moisturizing
- wrinkle
- crystal structure
- lamellar liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000004973 liquid crystal related substance Substances 0.000 title claims abstract description 48
- 239000006071 cream Substances 0.000 title claims abstract description 43
- 230000001153 anti-wrinkle effect Effects 0.000 title claims abstract description 34
- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 33
- 230000001815 facial effect Effects 0.000 title claims description 16
- 238000002360 preparation method Methods 0.000 title abstract description 11
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims abstract description 43
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims abstract description 23
- 229960003471 retinol Drugs 0.000 claims abstract description 23
- 235000020944 retinol Nutrition 0.000 claims abstract description 23
- 239000011607 retinol Substances 0.000 claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 15
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 13
- 229960001631 carbomer Drugs 0.000 claims abstract description 13
- 239000003974 emollient agent Substances 0.000 claims abstract description 13
- 239000003906 humectant Substances 0.000 claims abstract description 13
- 239000003755 preservative agent Substances 0.000 claims abstract description 10
- 230000002335 preservative effect Effects 0.000 claims abstract description 10
- 239000004519 grease Substances 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 4
- 150000005846 sugar alcohols Polymers 0.000 claims abstract description 3
- LODWEXDBRZBADB-XEVVZDEMSA-N (2s)-6-amino-2-[[(2s)-2-[[(2s)-6-amino-2-(hexadecanoylamino)hexanoyl]amino]-3-methylbutanoyl]amino]hexanoic acid Chemical compound CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(O)=O LODWEXDBRZBADB-XEVVZDEMSA-N 0.000 claims abstract 2
- 108010082495 Dietary Plant Proteins Proteins 0.000 claims abstract 2
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract 2
- 150000001720 carbohydrates Chemical class 0.000 claims abstract 2
- 229940094912 palmitoyl tripeptide-5 Drugs 0.000 claims abstract 2
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract 2
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract 2
- 229940006284 undaria pinnatifida extract Drugs 0.000 claims abstract 2
- -1 hydroxy pinacolone retinoic acid ester Chemical class 0.000 claims description 30
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 claims description 22
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 21
- 229930182478 glucoside Natural products 0.000 claims description 20
- 238000003756 stirring Methods 0.000 claims description 20
- 239000003921 oil Substances 0.000 claims description 18
- 235000019198 oils Nutrition 0.000 claims description 18
- 238000002156 mixing Methods 0.000 claims description 16
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 14
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 14
- 230000001804 emulsifying effect Effects 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 13
- 238000005303 weighing Methods 0.000 claims description 12
- 229960000735 docosanol Drugs 0.000 claims description 11
- 229920005862 polyol Polymers 0.000 claims description 10
- 150000003077 polyols Chemical class 0.000 claims description 10
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 9
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 8
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 8
- 240000000902 Diospyros discolor Species 0.000 claims description 8
- 235000003115 Diospyros discolor Nutrition 0.000 claims description 8
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 8
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 8
- 150000008131 glucosides Chemical class 0.000 claims description 8
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 8
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 8
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 8
- 229960005323 phenoxyethanol Drugs 0.000 claims description 8
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 8
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 7
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims description 7
- OEIJHBUUFURJLI-UHFFFAOYSA-N octane-1,8-diol Chemical compound OCCCCCCCCO OEIJHBUUFURJLI-UHFFFAOYSA-N 0.000 claims description 7
- 229940032094 squalane Drugs 0.000 claims description 7
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 7
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 6
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 6
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims description 6
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 4
- 238000007599 discharging Methods 0.000 claims description 4
- 239000011570 nicotinamide Substances 0.000 claims description 4
- 229960003966 nicotinamide Drugs 0.000 claims description 4
- 235000005152 nicotinamide Nutrition 0.000 claims description 4
- 239000004475 Arginine Substances 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 3
- 235000021314 Palmitic acid Nutrition 0.000 claims description 3
- 235000021355 Stearic acid Nutrition 0.000 claims description 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 3
- 229960000541 cetyl alcohol Drugs 0.000 claims description 3
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 claims description 3
- 238000004945 emulsification Methods 0.000 claims description 3
- 235000019441 ethanol Nutrition 0.000 claims description 3
- 238000000265 homogenisation Methods 0.000 claims description 3
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims description 3
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 3
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 3
- 238000004806 packaging method and process Methods 0.000 claims description 3
- 239000011241 protective layer Substances 0.000 claims description 3
- 230000001105 regulatory effect Effects 0.000 claims description 3
- 239000008117 stearic acid Substances 0.000 claims description 3
- 229940012831 stearyl alcohol Drugs 0.000 claims description 3
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 claims description 2
- 229940035437 1,3-propanediol Drugs 0.000 claims description 2
- 241000218993 Begonia Species 0.000 claims description 2
- 244000027321 Lychnis chalcedonica Species 0.000 claims description 2
- 244000151018 Maranta arundinacea Species 0.000 claims description 2
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 2
- 229940082500 cetostearyl alcohol Drugs 0.000 claims description 2
- 229920000166 polytrimethylene carbonate Polymers 0.000 claims description 2
- 229930002330 retinoic acid Natural products 0.000 claims 1
- 229960001727 tretinoin Drugs 0.000 claims 1
- 230000037303 wrinkles Effects 0.000 abstract description 9
- FFNOWYSCJOKVCL-UHFFFAOYSA-N 1-hydroxy-3,3-dimethylbutan-2-one Chemical compound CC(C)(C)C(=O)CO FFNOWYSCJOKVCL-UHFFFAOYSA-N 0.000 abstract description 4
- 239000007788 liquid Substances 0.000 abstract description 4
- 206010013786 Dry skin Diseases 0.000 abstract description 3
- 230000037394 skin elasticity Effects 0.000 abstract description 3
- 239000007787 solid Substances 0.000 abstract description 3
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 19
- 239000000047 product Substances 0.000 description 13
- 210000003491 skin Anatomy 0.000 description 12
- 238000013329 compounding Methods 0.000 description 9
- 238000009472 formulation Methods 0.000 description 6
- 230000002829 reductive effect Effects 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 5
- 235000011187 glycerol Nutrition 0.000 description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 206010067484 Adverse reaction Diseases 0.000 description 3
- 230000006838 adverse reaction Effects 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 239000010410 layer Substances 0.000 description 3
- 210000000434 stratum corneum Anatomy 0.000 description 3
- XLPLFRLIWKRQFT-XUJYDZMUSA-N (3,3-dimethyl-2-oxobutyl) (2e,4e,6e,8e)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoate Chemical compound CC(C)(C)C(=O)COC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C XLPLFRLIWKRQFT-XUJYDZMUSA-N 0.000 description 2
- 210000000245 forearm Anatomy 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 231100000430 skin reaction Toxicity 0.000 description 2
- GFTPTQVIOIDDRL-UHFFFAOYSA-N 2,3-dimethylbutane-1,2,3-triol Chemical compound CC(C)(O)C(C)(O)CO GFTPTQVIOIDDRL-UHFFFAOYSA-N 0.000 description 1
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 description 1
- 241000283153 Cetacea Species 0.000 description 1
- 206010051788 Sticky skin Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 239000012874 anionic emulsifier Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- HGKOWIQVWAQWDS-UHFFFAOYSA-N bis(16-methylheptadecyl) 2-hydroxybutanedioate Chemical compound CC(C)CCCCCCCCCCCCCCCOC(=O)CC(O)C(=O)OCCCCCCCCCCCCCCCC(C)C HGKOWIQVWAQWDS-UHFFFAOYSA-N 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- CNXJITYCNQNTBD-UHFFFAOYSA-L dipotassium;hexadecyl phosphate Chemical compound [K+].[K+].CCCCCCCCCCCCCCCCOP([O-])([O-])=O CNXJITYCNQNTBD-UHFFFAOYSA-L 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0295—Liquid crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/03—Liquid compositions with two or more distinct layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9711—Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Cosmetics (AREA)
Abstract
The application discloses moisturizing and anti-wrinkle face cream with a lamellar liquid crystal structure and a preparation method thereof, and relates to the field of skin care products, wherein the face cream comprises the following raw material components: water, a polyhydric alcohol humectant, an emulsifier, a grease emollient, retinol, hydroxy pinacolone retinol, carbomer, a pH regulator, nicotinamide, palmitoyl tripeptide-5, undaria pinnatifida extract, hydrolyzed vegetable protein, saccharide isomer, hydrolyzed sodium hyaluronate and a preservative. The application has the advantages that: the application combines the natural liquid crystal emulsifier with specific solid grease, liquid grease, water and carbomer to prepare the moisturizing and anti-wrinkle cream containing lamellar liquid crystal, and has the functions of long-acting moisturizing and improving skin roughness, skin elasticity and fine wrinkles.
Description
Technical Field
The application relates to the field of skin care products, in particular to moisturizing and anti-wrinkle cream with a lamellar liquid crystal structure and a preparation method thereof.
Background
The skin is an important organ of human body, has complex tissue structure, is tightly connected with other organs of human body, plays a barrier role, and protects the human body from external stimulus and injury. In recent years, with the continuous innovation of skin care products and pharmaceutical technology and the improvement of living standard of people, natural, safe, environment-friendly and functional skin care products are increasingly popular with consumers. Therefore, the development of the liquid crystal structure face cream using the natural raw materials can not only meet the requirements of consumers on moisturizing and anti-wrinkle performance, but also bring new skin care experience to the consumers.
A large amount of literature research data show that the face cream with the liquid crystal structure has the following advantages compared with other common face creams: firstly, the liquid crystal protective layer is formed, so that the formula has better stability; secondly, the lamellar liquid crystal structure is similar to the structure of lipid among human skin keratinocytes, so that the lamellar liquid crystal structure has better skin affinity; thirdly, the lamellar liquid crystal structure can wrap the active ingredients, so that the stability of the active ingredients is improved, and meanwhile, the release of the active ingredients can be slowed down, so that the action of the active ingredients is maximized; fourth, the skin-care product has excellent non-sticky skin feel.
The moisturizing and anti-wrinkle cream with the lamellar liquid crystal structure is an emulsifying system different from common creams, and the liquid crystal layer can wrap retinol and hydroxy-pinacolone retinoate in a formula, so that the irritation of the retinol can be reduced, the retinol and the hydroxy-pinacolone retinoate can be promoted to permeate below a skin cuticle, other moisturizing components and polypeptide components are compounded, and the skin roughness, skin elasticity and fine wrinkles can be effectively improved.
Disclosure of Invention
In order to solve the technical problems, the moisturizing and anti-wrinkle facial cream with a lamellar liquid crystal structure and the preparation method thereof are provided.
In order to achieve the above purpose, the application adopts the following technical scheme:
the moisturizing anti-wrinkle face cream with the lamellar liquid crystal structure comprises the following raw material components in percentage by weight:
preferably, the polyol humectant is one or more selected from glycerol, diglycerol, 1, 3-propanediol and butanediol.
Preferably, the emulsifier is selected from one or more of hydrogenated lecithin complex, PEG-20 phytosterol complex and cetylstearyl glucoside complex;
wherein the hydrogenated lecithin compound comprises one or more of hydrogenated lecithin, C12-16 alcohol, palmitic acid and stearic acid;
the PEG-20 phytosterol compound comprises one or more of PEG-20 phytosterol, cetyl alcohol, stearyl alcohol and behenyl alcohol;
the cetostearyl glucoside compound comprises one or more of cetostearyl glucoside, C12-18 alkyl glucoside, C12-20 alkyl glucoside and cetostearyl alcohol.
Preferably, the oil emollient is selected from one or more of squalane, caprylic/capric triglyceride, butter fruit, polydimethylsiloxane, begonia seed oil, and behenyl alcohol.
Preferably, the pH regulator is selected from one or more of sodium hydroxide, potassium hydroxide and arginine.
Preferably, the preservative is selected from one or more of phenoxyethanol, ethylhexyl glycerol, octyl glycol and 1,2 hexanediol.
Preferably, the moisturizing anti-wrinkle cream water interface is provided with a layered liquid crystal phase protective layer with a Malta cross structure.
Further, a preparation method of the moisturizing and anti-wrinkle facial cream with a lamellar liquid crystal structure is provided, and the preparation method comprises the following steps:
s1, weighing water, a polyol humectant and nicotinamide according to a proportion, adding the mixture into an emulsifying pot, and uniformly mixing and stirring;
s2, weighing carbomer according to the proportion, starting an emulsifying pot for slow homogenization, slowly scattering the carbomer into the pot, homogenizing for 5 minutes after the carbomer is added, confirming that the material is uniform, and then heating to 75-80 ℃;
s3, weighing a pH regulator according to the proportion, adding the pH regulator into an emulsifying pot, regulating the pH value to 6.0-7.0, stirring and homogenizing for 5 minutes, confirming that the material is uniform, and marking as a water phase;
s4, weighing the emulsifier and the grease emollient according to the proportion, heating to 75-80 ℃, uniformly stirring, adding retinol and hydroxy pinacolone retinol ester 1 minute before emulsification, and marking as an oil phase;
and S5, adding the oil phase into the stirred water phase, then adding other components weighed according to the proportion, and uniformly stirring to obtain the moisturizing and anti-wrinkle cream containing the lamellar liquid crystal.
Optionally, the specific operation steps of the step S5 are: adding the oil phase into the stirred water phase, stirring and homogenizing at 1400-1600rpm/min, emulsifying for 5min, stirring and cooling to 40-45deg.C, adding other components weighed according to the proportion, stirring uniformly, observing the liquid crystal structure containing Maranta cross in the face cream under polarized light condition by using a microscope, cooling to 20-25deg.C, and discharging to obtain the moisturizing and anti-wrinkle face cream containing lamellar liquid crystal.
Optionally, the discharging of the cream further comprises the following steps:
filling, packaging finished products, detecting finished products and leaving factories.
Compared with the prior art, the application has the advantages that:
according to the application, the natural liquid crystal type emulsifier with a specific dosage is compounded with the specific solid grease, the specific liquid grease, the specific water and the specific carbomer, and the preparation process is needed, so that the moisturizing and anti-wrinkle facial cream with lamellar liquid crystals can be obtained. Through the preparation process, retinol and hydroxy-pinacolone retinol can be wrapped in a lamellar liquid crystal structure, so that the irritation of retinol can be effectively reduced, meanwhile, the permeation of retinol and hydroxy-pinacolone retinol below the skin cuticle can be promoted, other moisturizing components and polypeptide components are compounded, and the skin roughness, skin elasticity and fine wrinkles can be effectively improved.
Drawings
FIG. 1 is a photomicrograph of a face cream of the present application;
fig. 2 is a flowchart of a method for preparing a face cream according to the present application.
Detailed Description
The following description is presented to enable one of ordinary skill in the art to make and use the application. The preferred embodiments in the following description are by way of example only and other obvious variations will occur to those skilled in the art.
The application provides a preparation method of moisturizing and anti-wrinkle cream with a lamellar liquid crystal structure, which comprises the following steps:
s1, weighing water, a polyol humectant and nicotinamide according to a proportion, adding the mixture into an emulsifying pot, and uniformly mixing and stirring;
s2, weighing carbomer according to the proportion, starting an emulsifying pot for slow homogenization, slowly scattering the carbomer into the pot, homogenizing for 5 minutes after the carbomer is added, confirming that the material is uniform, and then heating to 75-80 ℃;
s3, weighing a pH regulator according to the proportion, adding the pH regulator into an emulsifying pot, regulating the pH value to 6.0-7.0, stirring and homogenizing for 5 minutes, confirming that the material is uniform, and marking as a water phase;
s4, weighing the emulsifier and the grease emollient according to the proportion, heating to 75-80 ℃, uniformly stirring, adding retinol and hydroxy pinacolone retinol ester 1 minute before emulsification, and marking as an oil phase;
and S5, adding the oil phase into the stirred water phase, stirring and homogenizing at the rotating speed of 1400-1600rpm/min, emulsifying for 5min, stirring and cooling to 40-45 ℃, adding other components weighed according to the proportion, stirring uniformly, observing the liquid crystal structure containing the maltese cross in the face cream under the polarizing condition of a microscope for a sample, cooling to 20-25 ℃ and discharging to obtain the moisturizing and anti-wrinkle face cream containing the lamellar liquid crystal.
And (5) filling, packaging the finished product and detecting the finished product of the discharged face cream to leave the factory.
Further provides moisturizing and anti-wrinkle cream with a lamellar liquid crystal structure prepared based on the preparation method;
embodiment one:
in this embodiment, the following components in weight percentage:
in this embodiment: polyol humectant glycerin and butylene glycol according to 7:3, the mixture is prepared by matching the proportion of 3;
the emulsifier is a cetostearyl glucoside compound, and is specifically prepared by compounding cetostearyl glucoside and cetylstearyl alcohol according to a ratio of 3:1;
the oil emollient is prepared by mixing squalane, caprylic/capric triglyceride, butter fruit, polydimethylsiloxane, white pool flower seed oil and behenyl alcohol according to the proportion of 1:4:4:2:1:2.5;
the pH regulator is sodium hydroxide;
the preservative is prepared by mixing phenoxyethanol, octanediol and 1,2 hexanediol according to the proportion of 7:3:10.
Embodiment two:
in this embodiment, the following components in weight percentage:
in this embodiment: the polyalcohol humectant is diglycerol;
the emulsifier is prepared by compounding hydrogenated lecithin compound and PEG-20 phytosterol compound, and is specifically prepared by compounding PEG-20 phytosterol, cetyl alcohol, stearyl alcohol, behenyl alcohol and hydrogenated lecithin according to the ratio of 4:4:5:6:1;
the oil emollient is prepared by mixing squalane, caprylic/capric triglyceride, butter fruit, polydimethylsiloxane, white pool flower seed oil and behenyl alcohol according to the proportion of 1:4:4:2:1:2.5;
the pH regulator is formed by compounding sodium hydroxide and arginine;
the preservative is prepared by mixing phenoxyethanol, octanediol and 1,2 hexanediol according to the proportion of 7:3:10.
Embodiment III:
in this embodiment, the following components in weight percentage:
in this embodiment:
in this embodiment: the polyol humectant is 1,3 propylene glycol;
the emulsifier is prepared by compounding a hydrogenated lecithin compound, a PEG-20 phytosterol compound whale and a wax stearyl glucoside compound, and is specifically prepared by compounding PEG-20 phytosterol, C12-16 alcohol, palmitic acid, stearic acid, hydrogenated lecithin, C12-18 alkyl glucoside and C12-20 alkyl glucoside according to the proportion of 8:1:1:2:1:3:2;
the oil emollient is prepared by mixing squalane, caprylic/capric triglyceride, butter fruit, polydimethylsiloxane, white pool flower seed oil and behenyl alcohol according to the proportion of 1:4:4:2:1:2.5;
the pH regulator is potassium hydroxide;
the preservative is prepared by mixing phenoxyethanol, octanediol and 1,2 hexanediol according to the proportion of 7:3:10.
Comparative example one:
in this comparative example: the components and the weight percentages thereof are as follows:
in this comparative example: polyol humectant glycerin and butylene glycol according to 7:3, the mixture is prepared by matching the proportion of 3;
the emulsifier is a cetostearyl glucoside compound, and is specifically prepared by compounding cetostearyl glucoside and cetylstearyl alcohol according to a ratio of 3:1;
the oil emollient is prepared by mixing squalane, caprylic/capric triglyceride, butter fruit, polydimethylsiloxane, white pool flower seed oil and behenyl alcohol according to the proportion of 1:4:4:2:1:2.5;
the pH regulator is sodium hydroxide;
the preservative is prepared by mixing phenoxyethanol, octanediol and 1,2 hexanediol according to the proportion of 7:3:10.
Comparative example two:
in this comparative example: the components and the weight percentages thereof are as follows:
in this comparative example: polyol humectant glycerin and butylene glycol according to 7:3, the mixture is prepared by matching the proportion of 3;
the emulsifier is a cetostearyl glucoside compound, and is specifically prepared by compounding cetostearyl glucoside and cetylstearyl alcohol according to a ratio of 3:1;
the oil emollient is prepared by mixing squalane, caprylic/capric triglyceride, butter fruit, polydimethylsiloxane, white pool flower seed oil and behenyl alcohol according to the proportion of 1:4:4:2:1:2.5;
the pH regulator is sodium hydroxide;
the preservative is prepared by mixing phenoxyethanol, octanediol and 1,2 hexanediol according to the proportion of 7:3:10.
Comparative example three:
in this comparative example: the components and the weight percentages thereof are as follows:
in this comparative example: polyol humectant glycerin and butylene glycol according to 7:3, the mixture is prepared by matching the proportion of 3;
the emulsifier is a cetostearyl glucoside compound, and is specifically prepared by compounding cetostearyl glucoside and cetylstearyl alcohol according to a ratio of 3:1;
the oil emollient is prepared by mixing caprylic/capric triglyceride, butter fruit, polydimethylsiloxane and behenyl alcohol according to the proportion of 4:4:2:2.5;
the pH regulator is sodium hydroxide;
the preservative is prepared by mixing phenoxyethanol, octanediol and 1,2 hexanediol according to the proportion of 7:3:10.
Performance test:
experiment one: stability test
The test method comprises the following steps: the appearance of the samples was observed under a polarizing microscope by leaving the cream at 50, 40, 25, 5 and-18 ℃ for 12 weeks, and the results are shown in the following table:
in the system of example 1, the liquid crystal structure in the original system is destroyed when the anionic emulsifier, namely, cetyl phosphate potassium, is compounded; in the system of example 1, the replacement of the oils in the formulation with the highly polar oil diisostearyl malate also destroyed the liquid crystalline structure in the original system. In addition, the number of liquid crystal structures is reduced under high and low temperature conditions, but still within acceptable limits.
Experiment II: patch test
The testing method comprises the following steps: collecting 30 subjects meeting the requirements, selecting qualified patch equipment, placing about 0.020g-0.025g (solid) or 0.020mL-0.025mL (liquid) of the subject into a patch tester, applying a hyposensitization adhesive tape to the forearm curved side of the subject, removing the subject after 24 hours, observing skin response after 0.5, 24 and 48 hours respectively, and recording the results according to the skin response grading standard in the current effective technical specifications, wherein the results are shown in the following table:
/>
as can be seen from the data in the table, examples 1,2,3 and comparative example 2 do not have any adverse reaction; while comparative examples 1 and 3 have three adverse reactions, respectively, indicating the potential risk of irritation for comparative examples 1 and 3. The potential for adverse reactions in comparative examples 1 and 3 was due to retinol in the formulation; whereas examples 1,2, and 3 effectively encapsulate retinol due to the formation of a lamellar liquid crystal structure, thereby reducing direct contact with the skin.
Experiment III: short-term moisturizing test
The testing method comprises the following steps: the forearm of the subject was selected to have a measuring area of 2 x 2cm2, six sites were selected on both arms (for six experimental examples), and after cleaning, the product was applied to the area to be measured. The measurements of the moisture content of the stratum corneum in the area to be measured were carried out using a Corneometer (skin moisture tester) before use and 0h, 4h and 8h after use, respectively. The same site was measured 5 times, and the average value of 3 times was taken after excluding the maximum value and the minimum value. The values are the average of 5 subjects and the results are shown in the following table.
Parameter interpretation: the greater the stratum corneum moisture content value (core), the higher the stratum corneum moisture content of the skin.
From the data in the above table, the moisture increase rate of the horny layer was 52% after using the product of example 1 of the present application, and the moisture increase rate of the horny layer was still 34.2% after 8 hours of use. The skin moisture content after application of the product was significantly better than that of comparative examples 1,3, compared with comparative examples 1,3. It can be seen that the formulation containing the lamellar liquid crystal structure has more excellent moisture retention.
Experiment IV: long-acting anti-wrinkle test
Facial fine line wrinkle area and duty cycle were analyzed by IPP software using a VISIA-CR photograph. Parameter interpretation: the smaller the wrinkle area, the smaller the ratio, and the better the anti-wrinkle effect.
The using method comprises the following steps: subjects were divided into two groups of 15 subjects each. Using the half-face test, the first group of subjects used example 1 and comparative example 1 for their left and right faces, respectively; the second group of subjects used example 1 and comparative example 2 on their left and right faces. The using method comprises the following steps: the method is used once in the morning and evening every day, and facial image acquisition is carried out on the subjects after 2W and 4W respectively.
As can be seen from the data in the above table, using the products of inventive example 1 and comparative example 1, the wrinkle area was reduced by 15.2% and 10.7% after two weeks, respectively; after 4 weeks of use, the wrinkle area decreased by 17.9% and 13.4%, respectively. Therefore, the formula containing the liquid crystal structure has better anti-wrinkle effect. The possible reason is that the formulation of example 1 has a better permeability and thus a better anti-wrinkle effect, because the hydroxy pinacol retinol and retinol are encapsulated in the lamellar liquid crystal.
From the data in the above table, it can be seen that using the products of inventive example 1 and comparative example 2, the wrinkle area was reduced by 16.0% and 10.9% after two weeks, respectively; after 4 weeks of use, the wrinkle area was reduced by 17.1% and 12.4%, respectively. Thus, among the formulations containing liquid crystal structures, the formulations containing hydroxy pinacolone retinol and retinol have better anti-wrinkle effect.
In conclusion, the face cream provided by the application has a stable lamellar liquid crystal structure, and experiments show that the face cream has good moisturizing and anti-wrinkle effects.
The foregoing has shown and described the basic principles, principal features and advantages of the application. It will be understood by those skilled in the art that the present application is not limited to the embodiments described above, and that the above embodiments and descriptions are merely illustrative of the principles of the present application, and various changes and modifications may be made therein without departing from the spirit and scope of the application, which is defined by the appended claims. The scope of the application is defined by the appended claims and equivalents thereof.
Claims (8)
1. The moisturizing and anti-wrinkle facial cream with the lamellar liquid crystal structure is characterized by comprising the following raw material components in percentage by weight:
55% -75% of water;
8% -15% of a polyol humectant;
3.5% -6.5% of emulsifying agent;
10% -20% of grease emollient;
0.02% -0.08% of retinol;
0.01% -0.04% of hydroxy pinacolone retinoic acid ester;
carbomer 0.3% -0.5%;
0.1% -0.3% of pH regulator;
1% -3% of nicotinamide;
palmitoyl tripeptide-5, 0.001% -0.05%;
0.01% -0.05% of undaria pinnatifida extract;
0.001% -0.05% of hydrolyzed vegetable protein;
0.5% -2% of saccharide isomer;
0.03% -0.1% of hydrolyzed sodium hyaluronate;
0.8% -1.3% of preservative;
the emulsifier is one or more selected from hydrogenated lecithin complex, PEG-20 phytosterol complex and cetylstearyl glucoside complex;
wherein the hydrogenated lecithin compound comprises one or more of hydrogenated lecithin, C12-16 alcohol, palmitic acid and stearic acid;
the PEG-20 phytosterol compound comprises one or more of PEG-20 phytosterol, cetyl alcohol, stearyl alcohol and behenyl alcohol;
the cetostearyl glucoside compound comprises one or more of cetostearyl glucoside, C12-18 alkyl glucoside, C12-20 alkyl glucoside and cetostearyl alcohol;
the oil emollient consists of squalane, caprylic/capric triglyceride, butter fruit, polydimethylsiloxane, begonia seed oil and behenyl alcohol.
2. The moisturizing and anti-wrinkle facial cream with a lamellar liquid crystal structure according to claim 1, wherein the polyalcohol humectant is one or more selected from glycerol, diglycerol, 1,3 propanediol and butanediol.
3. The moisturizing and anti-wrinkle cream with the lamellar liquid crystal structure according to claim 1, wherein the pH regulator is one or more selected from sodium hydroxide, potassium hydroxide and arginine.
4. The moisturizing and anti-wrinkle facial cream with the lamellar liquid crystal structure according to claim 1, wherein the preservative is prepared by mixing phenoxyethanol, octanediol and 1,2 hexanediol according to the proportion of 7:3:10.
5. The moisturizing and anti-wrinkle facial cream with a layered liquid crystal structure according to claim 1, wherein the moisturizing and anti-wrinkle facial cream has a layered liquid crystal phase protective layer with a maltese cross structure at a water interface.
6. The method for preparing the moisturizing and anti-wrinkle facial cream with the lamellar liquid crystal structure according to any one of claims 1 to 5, which is characterized by comprising the following steps:
s1, weighing water, a polyol humectant and nicotinamide according to a proportion, adding the mixture into an emulsifying pot, and uniformly mixing and stirring;
s2, weighing carbomer according to the proportion, starting an emulsifying pot for slow homogenization, slowly scattering the carbomer into the pot, homogenizing for 5 minutes after the carbomer is added, confirming that the material is uniform, and then heating to 75-80 ℃;
s3, weighing a pH regulator according to the proportion, adding the pH regulator into an emulsifying pot, regulating the pH value to 6.0-7.0, stirring and homogenizing for 5 minutes, confirming that the material is uniform, and marking as a water phase;
s4, weighing the emulsifier and the grease emollient according to the proportion, heating to 75-80 ℃, uniformly stirring, adding retinol and hydroxy pinacolone retinol ester 1 minute before emulsification, and marking as an oil phase;
and S5, adding the oil phase into the stirred water phase, then adding other components weighed according to the proportion, and uniformly stirring to obtain the moisturizing and anti-wrinkle cream containing the lamellar liquid crystal.
7. The method for preparing the moisturizing and anti-wrinkle facial cream with the lamellar liquid crystal structure according to claim 6, wherein the specific operation steps of the step S5 are as follows: adding the oil phase into the stirred water phase, stirring and homogenizing at 1400-1600rpm/min, emulsifying for 5min, stirring and cooling to 40-45deg.C, adding other components weighed according to the proportion, stirring uniformly, observing the liquid crystal structure containing Maranta cross in the face cream under polarized light condition by using a microscope, cooling to 20-25deg.C, and discharging to obtain the moisturizing and anti-wrinkle face cream containing lamellar liquid crystal.
8. The method for preparing the moisturizing and anti-wrinkle facial cream with the lamellar liquid crystal structure according to claim 7, wherein the facial cream is discharged and further comprises the following steps:
filling, packaging finished products, detecting finished products and leaving factories.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210155833.XA CN114732743B (en) | 2022-02-21 | 2022-02-21 | Moisturizing anti-wrinkle facial cream with lamellar liquid crystal structure and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210155833.XA CN114732743B (en) | 2022-02-21 | 2022-02-21 | Moisturizing anti-wrinkle facial cream with lamellar liquid crystal structure and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114732743A CN114732743A (en) | 2022-07-12 |
| CN114732743B true CN114732743B (en) | 2023-10-20 |
Family
ID=82274602
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210155833.XA Active CN114732743B (en) | 2022-02-21 | 2022-02-21 | Moisturizing anti-wrinkle facial cream with lamellar liquid crystal structure and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114732743B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116059124A (en) * | 2023-03-06 | 2023-05-05 | 水羊化妆品制造有限公司 | Composition for improving gamma-aminobutyric acid irritation as well as preparation method and application thereof |
| CN117064771B (en) * | 2023-10-17 | 2023-12-12 | 清远市望莎生物科技有限公司 | Oil-in-water emulsifier and application thereof as well as daily chemical product |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110368323A (en) * | 2019-08-05 | 2019-10-25 | 广州市玉鑫化妆品有限公司 | A kind of composite skin care product and its preparation method and application containing liquid crystal emulsifier |
| CN110974742A (en) * | 2019-12-04 | 2020-04-10 | 威莱(广州)日用品有限公司 | Moisturizing and repairing hand cream with liquid crystal structure and preparation method thereof |
-
2022
- 2022-02-21 CN CN202210155833.XA patent/CN114732743B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110368323A (en) * | 2019-08-05 | 2019-10-25 | 广州市玉鑫化妆品有限公司 | A kind of composite skin care product and its preparation method and application containing liquid crystal emulsifier |
| CN110974742A (en) * | 2019-12-04 | 2020-04-10 | 威莱(广州)日用品有限公司 | Moisturizing and repairing hand cream with liquid crystal structure and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114732743A (en) | 2022-07-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN114732743B (en) | Moisturizing anti-wrinkle facial cream with lamellar liquid crystal structure and preparation method thereof | |
| JP2544198B2 (en) | Composition based on a hydratable lamellar phase or liposome consisting of an extract of mulberry and a pharmaceutical composition, in particular a dermatological composition with skin lightening or anti-inflammatory activity, or a cosmetic composition Stuff | |
| WO2018196482A1 (en) | Skin care cosmetic composition | |
| KR101384999B1 (en) | Organogel Composition and Organogel Mask Pack using Thereof | |
| US6607735B2 (en) | Method for reducing the appearance of dark circles under the eyes | |
| EP2772270A1 (en) | Emulsified hydrogel composition and a production method therefor | |
| CN108498382A (en) | A kind of moisturizing conveys nano-composition and its preparation method and application altogether | |
| KR20200051997A (en) | Cosmetic Composition For Improving Wrinkle Containing Retinol, Glutathione Or Tocopherol Stabilized By Nano-Structured Lipid Carrier | |
| CA2139018A1 (en) | Cosmetic and/or dermatologic composition for the treatment of aging comprising ceramids, and its use | |
| US20220339090A1 (en) | Retinal-containing multilamellar vesicle and cosmetic composition comprising same | |
| KR20130134532A (en) | Multilayer liquid crystal vesicle for relieving skin irritation and for recovering skin barrier, and cosmetic composition comprising the same | |
| KR101870514B1 (en) | Cosmetic composition comprising retinal liposome | |
| CN109157423A (en) | A kind of preparation method and application of water-in-oil nano-emulsion | |
| CN114617816B (en) | Anti-aging composition and preparation method thereof | |
| CN107213027B (en) | Cosmetic composition with skin repairing and moistening functions and preparation method thereof | |
| KR100545836B1 (en) | Cosmetic composition for skin irritation relief containing nanoliposomes of intracellular lipid components | |
| WO2022087666A1 (en) | Retinol compositions, methods of their preparation and use | |
| KR101003847B1 (en) | Skin -like complex composition | |
| JP2002161027A (en) | Method for suppressing inflammation and erythema and composition therefor | |
| KR100588743B1 (en) | Emulsion type-cosmetic composition containing liquid crystal having high moisturizing nature | |
| KR20110052095A (en) | Cosmetic composition for moisturizing of skin containing tremella fuciformis extracts | |
| KR20150107288A (en) | Emulsifier-Free Emulsion Cosmetic Formulations | |
| KR101694987B1 (en) | Oil-in-water solubilized cosmetic composition comprising hydrolyzed jojoba ester oil | |
| KR100858628B1 (en) | Cosmetic Composition for alleviating Skin Irritation Comprising Rumex Crispus L. Extract Stabilized in Nanoliposome | |
| CN103301044A (en) | Tea oil skin-moistening emulsion and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |