KR101384999B1 - Organogel Composition and Organogel Mask Pack using Thereof - Google Patents

Abstract

The present invention relates to an organogel mask pack composition and an organogel mask pack prepared using the same, and more particularly, to an organo comprising an oil, an oil gelling agent, water, a polyhydric alcohol, a gelling polymer and a skin active ingredient. It relates to a gel composition and an organogel mask pack prepared using the same.
In the organogel composition according to the present invention, since the organogel structure has a lamellar structure similar to that of the skin, skin affinity is improved, and thus, the delivery of the active ingredient of the skin can be easily and quickly performed. In addition, since the organogel composition according to the present invention has a relatively high oil content, it is easy to deliver various useful skin active ingredients, and can maintain skin moisture for a long time, thereby reducing the loss of transdermal moisture.

Description

Organogel composition and organogel mask pack prepared using the same {Organogel Composition and Organogel Mask Pack using Thereof}

The present invention relates to an organogel composition and an organogel mask pack prepared using the same, and more particularly, to an organogel composition having excellent percutaneous absorption properties of the skin active ingredients collected in the organogel, An organogel mask pack.

The term "organogel" was first used to describe the specific concept of gelation of oil in water inverse microemulsions (Luisi et al., Colloid & Polymer Science, 1990, vol. 268, pp. 356-374).

The term has recently been extended to a range that includes gelled, mainly hydrogenated, systems containing two oil in water, stabilized with phosphatidylcholine-rich lecithin (Williman et al., Journal of Pharmaceutical Sciences , 1992, vol. 81, pp. 871-874 and Schchipunov et al., Colloid Journal, 1995, vol. 57, pp. 556-560). Organogel has a lamellar phase similar to the skin structure and is characterized by having a gel form without a gelling agent.

Among the organogels, in particular, the lecithin organogel has a skin affinity because of its lamellar structure similar to that of the skin, and has been applied to a variety of cosmetic compositions because it can maintain moisture for the skin for a long time.

Korean Patent No. 0843155 discloses a skin whitening cosmetic composition in which vitamin C is stabilized with a lecithin gel, which is a lecithin-organo gel structure. The cosmetic composition for skin protection stabilized by stabilizing is disclosed.

On the other hand, it is expected to be useful as a mask pack if a more improved organogel composition can be obtained in which delivery of the skin active ingredient encapsulated in the organogel is easily and quickly obtained.

Accordingly, one aspect of the present invention is to provide an organogel composition to facilitate the percutaneous absorption of the skin active ingredient trapped in the organogel.

Another aspect of the present invention is to provide an organogel mask pack prepared using the organogel composition as described above.

According to one aspect of the present invention, there is provided an organogel composition comprising an oil, an oil gelling agent, a polyhydric alcohol, water, a gelling polymer and an active skin component.

According to another aspect of the present invention, an organogel mask pack prepared using the organogel composition is provided.

In the organogel composition according to the present invention, since the organogel structure has a lamellar structure similar to that of the skin, skin affinity is improved, and thus, the delivery of the active ingredient of the skin can be easily and quickly performed. In addition, since the organogel composition according to the present invention has a relatively high oil content, it is easy to deliver various useful skin active ingredients, and can maintain skin moisture for a long time, thereby reducing the loss of transdermal moisture.

According to one aspect of the invention, there is provided an organogel composition which can be easily transdermally absorbed skin active ingredient collected in the organogel.

More specifically, the organogel composition according to the present invention includes an oil, an oil gelling agent, a polyhydric alcohol, water, a gelling polymer and an active ingredient of the skin.

The oils that may be used in the present invention include isopropyl myristate, ethyl laurate, ethyl myristate, isopropyl palmitate, cyclopentane, cyclooctane, trans-decalin, n-pentane, n-hexane, But are not limited to, tripropylamine, tripropylamine, 1,7-octadiene, butyl laurate, cyclododecane, dibutyl ether, isooctane, n-octane, tributylamine, triisobutylamine, polyol ester, triglyceride, diglyceride, And may be at least one selected from the group consisting of ricin, carbohydrate, lipid, diglyceride, and fatty acid ester, and further may be caprylic / capric triglyceride, butyleneglycol dicaprylate / dicaprate, triethylhexanone, Ester-based oils such as neoate, isopropyl myristate and octyldodecanol; Hydrocarbon oils such as liquid paraffin, vaseline, hydrogenated polydecene and squalane; Waxes such as micro-stalin wax, beads wax and lanolin wax; Jojoba Oil, Avocado Oil, Almond Oil, Olive Oil, Sesame Oil, Wheat Germ Oil, Four Flower Oil, Camellia Oil, Castor Oil, Grape Seed Oil, Green Tea Seed Oil, Macadamia Nut Oil, Palm Oil, Rosehip Oil, Natural oils such as wood oil, argentine tree kernel oil and lavender oil, and silicone oils such as cyclomethicone, phenyltrimethicone, cyclopentasiloxane, dimethicone, and the like, It is not limited. Preferably, ester-based oils such as caprylic / capric triglyceride, butyleneglycolic dicaprylate / dicaprate, triethylhexanone, cetylethylhexanoate, isopropyl myristate and octyldodecanol are used do.

The oil may be included in an amount of 5 to 45% by weight, more preferably in an amount of 10 to 30% by weight, based on the total weight of the organogel composition for the mask pack. When the oil is included in less than 10% by weight based on the total weight of the organogel composition for the mask pack it is difficult to form the desired organogel because the content of the oil is relatively small, and thus the desired skin active ingredient If the transdermal absorption rate tends to be lowered and is included in an amount exceeding 45% by weight, the oil is separated from the aqueous phase, thereby making it difficult to manufacture the final mask pack.

The oil gelling agent may be at least one selected from the group consisting of lecithin, pluronic lecithin, sorbitan fatty acid esters, gelatin, L-lysine, limonene, and polyethylene, and mixtures thereof may also be used. .

The oil gelling agent may be included in an amount of 0.1 to 10% by weight, more preferably 3 to 7% by weight, based on the total weight of the organogel composition for the mask pack. When the oil gelling agent is added in less than 0.1% based on the total weight of the organogel composition for the mask pack, there is a problem that the oil is separated from the water phase without being mixed with the aqueous phase, and when included in excess of 10% by weight There is a problem that the elasticity of the obtained organogel falls.

The polyhydric alcohol which can be used in the present invention is used as a solvent with water, at least one selected from the group consisting of polyhydric alcohols such as glycerin, ethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, or It may be a mixture.

The polyhydric alcohol may be included in an amount of 0.5 to 35% by weight based on the total weight of the organogel composition, more preferably in an amount of 5 to 15% by weight. If it is less than 0.5% by weight, the dispersion of the gelling polymer tends to be difficult, and if it is more than 35% by weight, the gel content decreases over time because the water content is relatively low, and the stickiness is excessive when applied to the skin. Tends to increase.

On the other hand, the water contained in the organogel of the present invention is included in the amount of the balance, that is, the water is added in the final amount of 100% by weight of the total composition. On the other hand, it is preferable to add water dividingly to the extent that each component other than water can be melt | dissolved easily.

The gelling polymer may be selected from the group consisting of galactomannan, glucomannan, guar gum, locust bean gum, pluronic, agar, algin, carrageenan, xanthan, gellan, gelatin, methylcellulose, cellulose, carboxymethylcellulose and hydroxyethylcellulose Natural sugars; At least one member selected from the group consisting of polyacrylates or salts thereof, hydrophilic gelling agents such as polymethacrylic acid, carboxyvinyl polymer, polyvinyl alcohol, polyacrylamide, polyethylene oxide, polyethyleneimine, polyvinylpyrrolidone / RTI >

The gelling polymer may be included in an amount of 0.1 to 10% by weight, more preferably 0.5 to 5% by weight, based on the total weight of the organogel composition of the present invention. When the water-soluble polymer is added at less than 0.1% by weight based on the total weight of the organogel composition, it is possible to maintain the shape of the gel, but the strength of the gel is high and the flexibility is low, resulting in poor adhesion to the skin and exceeding 20% by weight. When added, the gel is liable to be difficult to maintain the shape and elasticity is difficult to manufacture a problem.

In the present invention, a crosslinked matrix may be obtained by adding at least two gelling polymers, and the matrix thus prepared is preferable for maintaining the form of the organogel when used as a skin care pack.

Most preferably from a group consisting of a branched polymer selected from the group consisting of galactomannan, glucomannan, guar gum, rocastine gum, and pluronic and agar, algin, carrageenan, xanthan, gellan, and gelatin It is preferable to mix at least one selected electrolyte polymer.

The electrolytic gelling polymer serves to maintain the composition of the present invention at normal room temperature (about 20 ℃), preferably in a gel state at a temperature of 0-30 ℃, branched gelling polymer when the temperature rise, That is, at 10-50 ° C., preferably at about 30-40 ° C. near the body temperature, the organogel of the present invention may be changed into a fluid state, and may be effectively applied to the skin.

At this time, it is preferable that the branched gelling polymer and the electrolytic gelling polymer are contained in an amount of 0.05-10 wt% and 0.05-5 wt%, respectively, based on the total weight of the composition, and if it is outside this range, Or when the temperature is raised, the phenomenon that the gel state changes into the fluid state may not occur.

In addition, in the composition of the present invention, the gelling polymer may be mixed with at least one or more crosslinking agents selected from acrylic polymers, styrene copolymers, and mixtures thereof, and a component preferred as the crosslinking agent may be, for example, sodium. Sodium Acrylates / C10-30 Alkyl Acrylate Crosspolymer or Potassium Acrylate / C10-30 Alkyl Acrylate Crosspolymer, Acrylate / C10-30 Alkyl Acrylate Crosspolymer Ethylhexyl Acrylate / HEMA / Styrene Copolymer, Butylene / Ethylene / Styrene Copolymer, Ammonium Acrylate / Styrene Copolymer Ammonium Acrylates / Methyl Styrene / Styrene Copolymer, Styrene / VP Copolymer and Styrene / One or two or more selected from the group consisting of acrylate copolymers (Styrene / Acrylates Copolymer) may be mentioned.

When the cross-linking agent is added, such a cross-linking agent not only serves to further improve the physical properties of the organo gel of the present invention, but also to form a thin film to better adhere to when used on the skin and maintain moisture effectively It may also serve to provide a soft texture to the organo gel of the present invention. The crosslinking agent may be added at 0.01 to 5% by weight based on the total weight of the organogel composition.

Furthermore, the skin active ingredient that may be included in the organogel composition for the mask pack is retinol, retinyl palmitate, retinyl acetate, retinoic acid, coenzyme qtene, elastin, collagen, hyaluronic acid, ceramide, collagen, caffeine, chitosan, ascorbic acid At least one selected from the group consisting of binic acid, ascorbylglucoside, alphabisabolol, tocopherol, tocopherol acetate, arbutin, niacinamide, adenosine, retinol acetate, vitamins A, D, E, and other natural extracts; It is preferable to use a mixture thereof.

When preparing a mask pack using the organogel composition for a mask pack according to the present invention, in particular, useful components such as tocopherol acetate, retinol acetate, vitamin A, D, E, ceramide, coenzymecuten, and alpha bisabolol, transdermal absorption rate This can be significantly improved.

The natural extract may be selected from the group consisting of aloe, green tea, ginseng, red ginseng, vinegar, ginkgo leaf, propolis, mulberry leaf, silkworm, snail mucilage, kakaduplum, camucam, yashiyaki, squalane, caviar, broccoli, , Raspberry, raspberry, raspberry, mackerel, mackerel, mackerel, mulberry root, raspberry, carrot, caffeine, Hamamelis, Spirulina, salmon roe, It is preferably at least one selected from the group consisting of edelweiss, chamomile, lavender, peppermint, eucalyptus, lemon balm, oregano, tea tree, golden,

The skin active ingredient may be contained in an amount of 0.05 to 10% by weight, more preferably 2 to 5% by weight, based on the weight of the whole composition. When the skin active ingredient is included in less than 0.1% by weight based on the total weight of the composition, the skin beauty effect is insignificant, and when included in excess of 20% by weight may cause skin irritation.

PH adjusters such as citric acid, potassium hydroxide and arginine, depending on the application and necessity; Preservatives such as parabens such as methylparaben, propylparaben and phenoxyethanol; Metal ion sequestrants such as 2Na EDTA; Other additives such as betaine, sorbitol, 1,2-hexanediol, moisturizers such as erythritol and the like may be added.

The other additives may be included in an amount of 0.01 to 10% by weight, and more preferably 0.05 to 5% by weight, based on the total weight of the organogel composition of the present invention.

Since the organogel according to the present invention has a lamellar structure similar to that of the skin, skin affinity is improved, thereby allowing the skin active ingredient to be easily and quickly transferred from the organogel to the skin. Furthermore, the organogel according to the present invention has a relatively high oil content and is easy to deliver useful skin active ingredients, and can maintain skin moisture for a long time, thereby reducing transdermal moisture loss.

On the other hand, the mask pack using the organogel composition according to the present invention can be prepared by the following process.

First, if necessary for some water, other additives are mixed and heated to about 70-80 ° C. to dissolve the components. Here, the mixture obtained by adding the gelled polymer, the skin beauty ingredient, and the polyhydric alcohol to the remainder of the water was added, mixed, and stirred to form a uniform solution. At this time, a crosslinking agent can be further added as needed. If the temperature is less than 70 ℃ component is added to water is not completely dissolved, if more than 80 ℃ may be the stability of some additives or natural components.

In the preparation of the organogel of the present invention, water may be added in an appropriate amount so that each component may be easily dissolved in the final amount of the total composition to 100% by weight.

Alternatively, the oil, oil gelling agent is heated to about 70 to 80 ℃ The added mixture is slowly added dropwise to the mixed solution with stirring to prepare an organogel solution. Other additives such as preservatives may be further included if required. When the temperature is less than 70 ℃ during mixing, the aqueous phase and the oil phase is not easily mixed, it is difficult to manufacture the organogel, if the temperature exceeds 80 ℃, the stability of the material added to the water phase and the oil phase is lowered There is concern.

The organogel solution thus obtained is coated on a support, then cooled to room temperature, and molded into a desired shape to prepare an organogel mask pack.

The support may be nylon, rayon, nonwoven fabric or the like, and preferably a rayon mesh fabric may be used.

The organogel mask pack may be molded into a desired shape suitable for body parts such as face, eyes, cheeks, chin, neck, etc. to obtain a final organogel mask pack. Furthermore, both sides of the organogel mask pack may be It can be protected with a film.

The organogel composition coated on the support is preferably a thickness of 0.01 to 50mm, if the thickness is less than 0.01mm may cause a problem that the gel is torn when attached to the skin, the active ingredient included in the gel Since the amount is small, there is a problem that they are not sufficiently delivered to the skin, and if it exceeds 50mm, because the gel is excessively thick, there is a problem of poor adhesion to the skin.

Hereinafter, the present invention will be described more specifically by way of specific examples. The following examples are given for the purpose of helping to understand the present invention, but the scope of the present invention is not limited thereto.

Example

< Example >

One. Organogel Mask pack  Produce

Example  1 and 2

First, EDTA 2Na, betaine and methylparaben were mixed in the first purified water and heated to about 75 to 80 ° C. to dissolve the components. Here, the solution which mixed niacinamide, butylene glycol, glycerin, carrageenan, and locustvin gum was added and mixed to 2nd purified water. In the case of Examples 1 and 2, the respective contents of the components are as described in Table 1 below.

Separately, a mixture of Caprylic / Capric Triglyceride (MCT), lecithin and propylparaben heated to 75-80 ° C. was slowly added dropwise with stirring to the solution to prepare an organogel solution.

The organogel solution was coated with a rayon mesh fabric as a wick and coated on both sides, and then molded into a desired shape to prepare an organogel mask pack.

NO. Raw material name Example 1 Example 2 One First purified water 43.62 80.02 2 EDTA 2Na 0.01 0.01 3 Betaine 0.5 0.1 4 Methyl paraben 0.2 0.2 5 Second purified water 10 10 6 Niacinamide 2 2 7 Butylene Glycol (1,3) 2 - 8 glycerin 5 0.5 9 Locust bean sword 1.2 1.2 10 Carrageenan 0.45 0.45 11 Caprylic / Capric Triglyceride (MCT) 30 5 12 lecithin 5 0.5 13 Propylparaben 0.02 0.02

Example  3 and 4

First, EDTA 2Na, sorbitol, methylparaben and sodium acrylate / C 10-30 alkyl acrylate crosspolymer were mixed in the first purified water and heated to about 75 to 80 ° C. to dissolve the components. Here, the solution which mixed tocopherol acetate, glycerin, carrageenan, and locustbin gum was added and mixed to 2nd purified water. In the case of Examples 3 and 4, the respective contents of the components are as shown in Table 2 below.

Separately, an organogel solution was prepared by dropwise addition of butyleneglycoldicaprylate / dicaprate or a mixture of triethylhexanoin and lecithin heated to 75-80 ° C. with stirring.

The organogel solution was coated with a rayon mesh fabric as a wick and coated on both sides, and then molded into a desired shape to prepare an organogel mask pack.

NO. Raw material name Example 3 Example 4 One First purified water 67.62 60.57 2 EDTA 2Na 0.01 0.01 3 Sorbitol 0.5 0.5 4 Methyl paraben 0.2 0.2 5 Second purified water 10 10 6 Tocopherol acetate 2 2 7 glycerin 2 4 8 Locust bean sword 1.2 0.5 9 Carrageenan 0.45 0.2 10 Butyleneglycol dicaprylate / dicaprate 15 - Triethylhexanone - 20 11 lecithin One 2 12 Sodium Acrylate / C10-30 Alkylacrylate Crosspolymer 0.02 0.02

Example  5 and 6

First, EDTA 2Na, sorbitol, butylene / ethylene / styrene copolymer and methylparaben were mixed in the first purified water and heated to about 75 to 80 ° C. to dissolve the components. Here, the solution which mixed alpha bisabolol, glycerin, carrageenan, and glucomannan to the 2nd purified water was added and mixed. In the case of Examples 5 and 6, each content of the above components is as described in Table 3 below.

Separately, a mixture of cetylethylhexanoate or isopropyl myristate and lecithin or pluronic lecithin heated to 75-80 ° C. was slowly added dropwise with stirring to the solution to prepare an organogel solution.

The organogel solution was coated with a rayon mesh fabric as a wick and coated on both sides, and then molded into a desired shape to prepare an organogel mask pack.

NO. Raw material name Example 5 Example 6 One First purified water 51.62 43.62 2 EDTA 2Na 0.01 0.01 3 Sorbitol 0.5 0.5 4 Methyl paraben 0.2 0.2 5 Second purified water 10 10 6 Alpha-bisabolol 2 2 7 glycerin 6 8 8 Glucomannan 1.2 1.2 9 Carrageenan 0.45 0.45 10 Cetyl ethyl hexanoate 25 - Isopropyl myristate 30 11 lecithin 3 - Pluronic Lecithin - 4 12 Butylene / Ethylene / Styrene Copolymer 0.02 0.02

Example  7 and 8

First, EDTA 2Na, sorbitol, butylene / ethylene / styrene copolymer and methylparaben were mixed in the first purified water and heated to about 75 to 80 ° C. to dissolve the components. Here, the solution which mixed alpha bisabolol, glycerin, glucomannan and gellan or carrageenan was added and mixed to 2nd purified water. In the case of Examples 7 and 8, each content of the above components is as described in Table 4 below.

Separately, a mixture of cetylethylhexanoate or isopropyl myristate and lecithin or pluronic lecithin heated to 75-80 ° C. was slowly added dropwise with stirring to the solution to prepare an organogel solution.

The organogel solution was coated with a rayon mesh fabric as a wick and coated on both sides, and then molded into a desired shape to prepare an organogel mask pack.

NO. Raw material name Example 7 Example 8 One First purified water 38.02 30.30 2 EDTA 2Na 0.01 0.01 3 Sorbitol 0.5 0.5 4 Methyl paraben 0.2 0.2 5 Second purified water 10 10 6 Alpha-bisabolol 0.1 2.0 7 glycerin 10 12 8 Glucomannan 1.2 1.2 9 Carrageenan 0.45 - Guerlan - 0.45 10 Cetyl ethyl hexanoate 35 - Isopropyl myristate - 40 11 lecithin 4.5 - Pluronic Lecithin 3.5 12 Butylene / Ethylene / Styrene Copolymer 0.02 0.02

Comparative Example  1 and 2

First, EDTA 2Na, betaine and methylparaben were mixed in the first purified water and heated to about 75 to 80 ° C. to dissolve the components. Here, the solution which mixed tocopherol acetate, glycerin, locust bean gum, and carrageenan was added and mixed to 2nd purified water. In the case of Comparative Examples 1 and 2, the respective contents of the components are as described in Table 5 below.

Separately, a mixture of MTC, lecithin and propylparaben heated to 75-80 ° C. was slowly added dropwise with stirring to the solution to prepare an organogel solution.

The organogel solution was coated with a rayon mesh fabric as a wick and coated on both sides, and then molded into a desired shape to prepare an organogel mask pack.

NO. Raw material name Comparative Example 1 Comparative Example 2 One First purified water 80.02 10.62 2 EDTA 2Na 0.01 0.01 3 Betaine 0.5 0.5 4 Methyl paraben 0.2 0.2 5 Second purified water 10 10 6 Tocopherol acetate 2 2 7 glycerin 2.5 15 8 Locust bean sword 1.2 1.2 9 Carrageenan 0.45 0.45 10 Caprylic / Capric Triglyceride (MCT) 3 50 11 lecithin 0.1 10 12 Propylparaben 0.02 0.02

2. Organogel Mask pack  Property evaluation

The physical properties of the organogel mask packs prepared in Examples and Comparative Examples were measured, and the results are shown in the following table.

(1) Evaluation of moisturizing degree

The organogel was cut into a 10 mm diameter circle, and the initial weight thereof was measured. Then, the organogel was attached to the inside of the upper arm of 20 healthy women for 30 minutes, and then detached. In order to prevent evaporation of moisture, a vinyl of the same size as the organogel was covered and fixed.

Moisturizing power of organogel-attached skin was measured using Corneometer CM 825 (Courage and Khazaka, Germany), a device that measures capacitance in vivo in a non-invasive manner. The amount of water loss (g / m ² h) was measured using Tewarmeter TM210 (Courage and khazaka, Germany), a device for measuring transepidermal water loss (TEWL).

The measurement was performed for each of 20 people, the average value of the values obtained from them was obtained, and the results are shown in Table 6 below.

(2) Evaluation of skin irritation degree

Organogel was cut into a 10 mm diameter circle, attached to the inner arm upper arm of 20 healthy women, detached after 24 hours, and visually evaluated the condition of the skin and evaluated according to the following evaluation criteria. 6 is shown.

◎: No stimulation

○: weak stimulus

□: Erythema

Δ: erythema and edema

X: Erythema, edema and blisters

(3) Evaluation of stability (discoloration, gel strength, phase separation)

While leaving the organogel in air at 25 ° C, the physical change of the organogel was visually measured with the passage of 60 minutes, 5 hours, 10 hours, 24 hours, and evaluated according to the following evaluation criteria. It is shown in Table 6 below.

◎: Maintain property

○: less than 10% of total area, discoloration, gel strength (dryness), phase separation

□: Less than 30% of the total area shows discoloration, gel strength (dryness), phase separation

?: Less than 50% of the total area, discoloration, gel strength (dryness), phase separation

X: Less than 80% of the total area, discoloration, gel strength (dryness), phase separation

division Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Comparative Example 2 Moisturizing Weight (g) difference 0.3 0.35 0.2 0.21 0.28 No formulation Early
Corneometer Value (AU) 32.0 29.0 28.7 30.3 27.2 No formulation 30 minutes later
Corneometer Value (AU) 35.5 34.1 33.4 34.1 29.1 No formulation Initial Tewarmeter Value
(g / m ² h) 7.0 6.5 6.5 6.5 4.7 No formulation 30 minutes later
Tewarmeter value (g / m ² h) 6.3 5.4 5.5 5.7 4.5 No formulation Skin irritation ◎ ◎ ◎ ◎ ○ No formulation stability 60 minutes ◎ ◎ ◎ ◎ □ No formulation 5 hours ◎ ◎ ◎ ◎ △ No formulation 10 hours ◎ ◎ ◎ ◎ X No formulation 24 hours ◎ ◎ ◎ ◎ X No formulation

As shown in Table 6, Examples 1 to 4 of the present invention can be confirmed that the excellent moisturizing degree, skin irritation degree and stability. On the other hand, in Comparative Example 1, the moisturizing degree, skin irritation degree and stability were insufficient, and Comparative Example 2 was unable to measure the physical properties of the formulation itself.

(4) evaluation of transdermal absorption efficiency

In vitro skin penetration tests were carried out using the skin of hairless mice. 48 microliters of the samples of Examples 3 and 4 and Comparative Example 1 were respectively applied to the surface of the mouse skin having a diameter of 15.0 mm, and the amount of tocopherol acetate permeated after 24 hours using a Hanson Microette was analyzed by liquid chromatography. Quantification, the results are shown in Table 7 below. As shown in Table 7, it can be seen that the transdermal absorption efficiency of Examples 3 and 4 according to the present invention is superior to Comparative Example 1.

sample Example 3 Example 4 Comparative Example 1 Transmittance 15.3% 16.1% 7.2%

(5) wrinkle improvement evaluation

Organogels prepared according to Examples 3 and 4 and Comparative Example 1 were uniformly attached in a round shape of 20 mm around the eyes twice a day for 20 women aged 40 to 60 years. The experiment was conducted for a total of 3 months, which was defined as crow's feet. The organogel prepared in Example 3 or 4 was applied to the left eye of the test subject, and the composition prepared in Comparative Example 1 was applied to the right eye.

Three months after the organogel was applied, the degree of wrinkles was visually determined (no improvement, slight improvement, moderate improvement, and significant improvement compared with the control group), and the results are shown in Table 8 below. .

division No improvement Slight improvement Moderate improvement A significant improvement Example 3 One 2 3 4 Example 4 0 2 4 4 Comparative Example 1 3 3 3 One

Furthermore, the depth of wrinkles (μm) was measured by using an image analysis method in relation to the eye wrinkle wrinkle (replica) before and after application of the organogel, and as a result, the wrinkle depth reduction rate is shown in Table 9 below.

division Example 3 Example 4 Comparative Example 1 Before application 325 ± 41 308 ± 39 295 ± 35 90 days after application 179 ± 41 255 ± 32 276 ± 37 Wrinkle depth reduction rate 14.10% 17.20% 6.40%

As shown in Tables 8 and 9, the organogel prepared according to the present invention can be confirmed that the transdermal absorption efficiency is excellent and also effective in improving wrinkles.

Claims (16)

Purified water 53.62%, EDTA 2Na 0.01%, sorbitol 0.5%, methylparaben 0.2%, alpha bisabolol 2%, glycerin 8%, glucomannan 1.2%, carrageenan 0.45%, isopropyl myristate 30% An organogel layer formed of an organogel composition comprising%, 4% by weight of pluronic lecithin and 0.02% by weight of butylene / ethylene / styrene copolymer;
And a support,
The organogel layer is an organogel mask pack coated with a thickness of 0.01 to 50mm on the support.
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