CN110075003B - Water-replenishing and freckle-removing cream containing beta-glucan and preparation method thereof - Google Patents
Water-replenishing and freckle-removing cream containing beta-glucan and preparation method thereof Download PDFInfo
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- CN110075003B CN110075003B CN201910458980.2A CN201910458980A CN110075003B CN 110075003 B CN110075003 B CN 110075003B CN 201910458980 A CN201910458980 A CN 201910458980A CN 110075003 B CN110075003 B CN 110075003B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Abstract
The invention discloses a moisturizing and freckle-removing cream containing beta-glucan and a preparation method thereof, and belongs to the technical field of skin care products. The components of the moisturizing and freckle-removing cream containing the beta-glucan comprise tranexamic acid, yeast peptide, coated yeast fermentation product filtrate, rice fermentation product filtrate, snow lotus fermentation liquor, nicotinamide, beta-glucan, tremella sporophore extract and the like, and the yeast peptide, the rice fermentation product filtrate and the snow lotus fermentation liquor are all natural, organic, efficient, healthy and safe freckle-removing components, so that the moisturizing and freckle-removing cream containing the beta-glucan is high in safety and can effectively resist skin melanin and freckles; in the implementation process, the mass ratio of the beta-glucan to the tremella sporophore extract is controlled, so that the prepared water-replenishing and freckle-removing cream has excellent water-replenishing performance.
Description
Technical Field
The invention belongs to the technical field of skin care products, and particularly relates to a moisturizing and freckle removing cream containing beta-glucan and a preparation method thereof.
Background
The skin can protect internal tissues and organs of a human body from being damaged, can prevent water in the human body from losing, can prevent harmful substances from invading the human body, therefore, the skin is an important tissue of the human body, is more directly used for expressing the signs of human health and aging, however, when the metabolism is abnormal, the skin is exposed to strong ultraviolet rays, the mental stress is applied, the cosmetics are mistakenly used, and the like, the color of the spot is deepened, the spot is a common skin disease with brown or melanosis and damage on the face, which is formed by the increase of skin melanin, the spot is frequently generated on the cheek and the forehead, the spot is aggravated after the sun is sunned, and is often seen in women, the color spot is only influenced by beauty if the color spot is slightly existed, and the serious patient can bring great influence to physical and psychological health of the patient, thereby influencing normal life of the patient.
With the continuous improvement of the current social and economic levels and the abundance of material life, people pay more and more attention to the external image of individuals, so that skin care products also become popular with women, and various skin care product types such as facial cleanser (cream/cream), emollient water, toner, mask, facial cream, mascara and the like are presented on the market. For a single product, manufacturers also develop different functional products, such as whitening, freckle removing, moisturizing, oil control and the like.
When the metabolism of the organism is correspondingly weakened along with the aging, the melanin reducing capability is weakened, and the melanin is deposited in the lower layer of the skin; in addition, the formation of melanin is increased by the acceleration of life pace, irregular work and rest, frequent use of electronic products, and use of some cosmetics containing heavy metals. At present, a plurality of skin care products with freckle removing functions are available on the market, such as various freckle removing creams, but because the freckle removing creams are more in variety, a plurality of compounds are often added into the products to enable the products to have better effects so as to enable the products to have more obvious effects, but due to the addition of the compounds, the freckle removing creams have great side effects, such as reactions of dry skin, rebound after being taken out of service and the like.
For example, chinese patent application 201611250583.9 discloses a whitening spot-removing cream and a preparation method thereof, wherein the whitening spot-removing cream comprises: water, butylene glycol, caprylic/capric triglyceride, isohexadecane, glycerol, cyclopentadimethylsiloxane, shea butter, trehalose, cetearyl olivate oleate, sorbitan olivate, cetearyl alcohol, cetearyl glucoside, magnolia sieboldii extract, citrus peel extract, hydrogenated lecithin, phytosterols, bisabolol, tocopherol acetate, glycyrrhiza glabra root extract, thyme extract, panthenol, and sodium hyaluronate, and the like. The whitening and freckle-removing cream disclosed by the invention can inhibit the activities of tyrosinase and dopachrome tautomerase, inhibit the polymerization of DHI, internally inhibit the formation of melanin, improve the pigment cell renewal capacity, reduce the pigmentation, promote the pigment cell to fall off, enhance the cell immunity, improve the skin elasticity and metabolism function, improve the skin self-protection capacity, and achieve the effects of safely whitening and removing freckles, but the invention does not pay attention to the water replenishing performance of the freckle-removing cream.
The Chinese patent application 201610148113.5 discloses a whitening and freckle-removing composition, a whitening and freckle-removing cream and a preparation method thereof, the whitening and freckle-removing composition disclosed by the invention is prepared by compounding a plant extract and a traditional whitening component, the problems of poor safety and high irritation of the traditional whitening and freckle-removing active component are solved, the heat resistance, oxidation resistance and ultraviolet resistance of the whitening and freckle-removing active component can be improved, and the whitening and freckle-removing composition is safer, more stable and more efficient than other whitening and freckle-removing components, and meanwhile, the composition also has the effects of wrinkle resistance and aging resistance, but the application does not pay attention to the water replenishing and water locking performance of the freckle-removing cream.
Disclosure of Invention
In order to solve the problems and the defects in the prior art, the invention aims to provide the moisturizing and freckle-removing cream containing the beta-glucan and the preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
the moisturizing and freckle-removing cream containing the beta-glucan comprises the following components in percentage by weight: 1-5% of a mixture of candelilla wax/jojoba/rice bran polyglycerol-3 esters, glyceryl stearate, 1-5% of cetostearyl alcohol and sodium stearoyl lactylate, 1-5% of a mixture of jojoba esters, cercis chinensis wax, sunflower seed wax and polyglycerol-3, 1-3% of tranexamic acid, 1-3% of yeast peptide, 1-3% of saussurea involucrata fermentation liquid, 1-3% of nicotinamide, 0.01-0.3% of beta-glucan, 0.01-0.2% of TREMELLA FUCIFORMIS (Tremella FUCIFORMIS) fruiting body extract and the balance of water.
Preferably, the moisturizing and freckle-removing cream comprises the following components in percentage by weight: 1.5-4.5% of a mixture of candelilla wax/jojoba/rice bran polyglycerol-3 esters, glyceryl stearate, 1.5-4.5% of cetostearyl alcohol and sodium stearoyl lactylate, 1.5-4.5% of a mixture of jojoba esters, cercis chinensis wax, sunflower seed wax and polyglycerol-3, 1.2-2.8% of tranexamic acid, 1.2-2.8% of yeast peptide, 1.2-2.8% of saussurea involucrate fermentation liquor, 1.2-2.8% of nicotinamide, 0.05-0.25% of beta-glucan, 0.05-0.18% of a TREMELLA (tremula FUCIFORMIS) solid extract and the balance of water.
The moisturizing and freckle-removing cream also comprises the following components in percentage by weight: 1-10% of hydrogenated polybutylene, 1-8% of 1, 3-propylene glycol, 1-6% of isostearyl isostearate, 1-5% of betaine, 1-5% of pentaerythritol tetra (ethyl hexanoate), 1-5% of propyl heptyl caprylate, 1-5% of glycerol, 1-5% of 1, 2-pentanediol, 11-5% of biogum gum, 1-3% of a mixture of water, glycerol, acrylic acid/MA copolymer sodium and propylene glycol, 1-3% of a membrane-covered yeast fermentation product filtrate, 1-3% of a rice fermentation product filtrate, 1-3% of behenyl alcohol, 1-3% of polydimethylsiloxane, 1-3% of a mixture of glycerol stearate and PEG-100 glycerol stearate, 1-3% of shea butter (TYROSPERMENUM PAR) fruit fat, 1-3% of phytosterol/octyldodecanol lauroyl glutamate, 1-3% of glyceramide ethanol methacrylate/stearyl alcohol methacrylate copolymer, 0.1-2% of medicinal rhubarb extract, 0.1-2% of nano-encapsulated ceramide, 0.1-1% of tocopherol acetate, 0.1-1% of allantoin, 0.01-0.2% of sodium polyglutamate, 0.01-0.2% of sodium hyaluronate, 0.01-0.2% of ammonium acryloyldimethyl taurate/VP copolymer, 0.01-0.2% of stearic acid, 0.01-0.2% of preservative, 0.01-0.2% of carboxymethyl chitosan, 0.01-0.2% of p-hydroxyacetophenone, 0.01-0.2% of xanthan gum and 0.01-0.2% of essence.
Preferably, the moisturizing and freckle-removing cream further comprises the following components in percentage by weight: 2-9% of hydrogenated polybutylene, 2-7% of 1, 3-propylene glycol, 2-5% of isostearyl alcohol isostearate, 1.5-4.5% of betaine, 1.5-4.5% of pentaerythritol tetra (ethyl hexanoate), 1.5-4.5% of propyl heptyl caprylate, 1.5-4.5% of glycerol, 1.5-2-4.5% of 1, 2-pentanediol, 11.5-4.5% of bioglycan gum, 1.2-2.8% of a mixture of water, glycerol, acrylic acid/MA copolymer sodium and propylene glycol, 1.2-2.8% of a film covering fermentation product filtrate, 1.2-2.8% of a rice fermentation product filtrate, 1.2-2.8% of behenyl alcohol, 1.2-2.8% of polydimethylsiloxane, 1701.2-2.8% of a mixture of glycerol stearate and PEG-100 glycerol stearate, 1.2-2.8% of Butyrospermum parka fruit fat (BUROSPERM PARK), 1.2 to 2.8 percent of phytosterol/octyldodecanol lauroyl glutamate, 1.2 to 2.8 percent of glyceramide ethanol methacrylate/stearyl alcohol methacrylate copolymer, 0.5 to 1.8 percent of medicinal rhubarb extract, 0.5 to 1.8 percent of nano-encapsulated ceramide, 0.2 to 0.9 percent of tocopherol acetate, 0.2 to 0.9 percent of allantoin, 0.05 to 0.18 percent of sodium polyglutamate, 0.05 to 0.18 percent of sodium hyaluronate, 0.05 to 0.18 percent of ammonium acryloyldimethyl taurate/VP copolymer, 0.05 to 0.18 percent of stearic acid, 0.05 to 0.18 percent of preservative, 0.05 to 0.18 percent of carboxymethyl chitosan, 0.05 to 0.18 percent of p-hydroxyacetophenone, 0.05 to 0.18 percent of xanthan gum and 0.05 to 0.18 percent of essence.
Preferably, the moisturizing and freckle-removing cream further comprises the following components in percentage by weight: 3 to 8 percent of hydrogenated polybutene, 3 to 6 percent of 1, 3-propylene glycol, 2.5 to 3.5 percent of isostearyl isostearate, 2.5 to 3.5 percent of candelilla wax/jojoba/rice bran polyglycerol-3 esters, 2 to 4 percent of glycerol stearate, 2 to 4 percent of mixture of cetostearyl alcohol and sodium stearoyl lactylate, 2 to 4 percent of betaine, 2 to 4 percent of jojoba esters, ceryl green tree flower wax, 2 to 4 percent of mixture of sunflower seed wax and polyglycerol-3, 2 to 4 percent of pentaerythritol tetra (ethyl hexanoate), 2 to 4 percent of caprylic propyl heptyl ester, 2 to 4 percent of glycerol, 2 to 4 percent of 1, 2-pentanediol, 12 to 4 percent of biogum gum, 1.5 to 2.5 percent of mixture of water, glycerol, acrylic acid/MA copolymer sodium and propylene glycol, 1.5 to 2.5 percent of tranexamic acid, 1.5-2.5% of yeast peptide, 1.5-2.5% of covered yeast fermentation product filtrate, 1.5-2.5% of rice fermentation product filtrate, 1.5-2.5% of saussurea involucrate fermentation broth, 1.5-2.5% of behenyl alcohol, 1.5-2.5% of polydimethylsiloxane, 1.5-2.5% of nicotinamide, 1.5-2.5% of mixture of glycerol stearate and PEG-100 glycerol stearate, 1.5-2.5% of fruit fat of Butyrospermum parkii (Butyrum parkm), 1.5-2.5% of phytosterol/octyldodecanol lauroyl glutamate, 1.5-2.5% of glyceramide ethanol methacrylate/stearyl alcohol methacrylate copolymer, 0.8-1.5% of medicinal rhubarb extract, 0.8-1.5% of nano-encapsulated ceramide, 0.3-0.8% of tocopherol acetate, 0.3-0.8% of allantoin, and 0.1-0.2.2% of beta-glucan, 0.08-0.15% of TREMELLA (Tremella FUCIFORMIS) fruiting body extract, 0.08-0.15% of sodium polyglutamate, 0.08-0.15% of sodium hyaluronate, 0.08-0.15% of ammonium acryloyldimethyl taurate/VP copolymer, 0.08-0.15% of stearic acid, 0.08-0.15% of preservative, 0.08-0.15% of carboxymethyl chitosan, 0.08-0.15% of p-hydroxyacetophenone, 0.08-0.15% of xanthan gum, 0.08-0.15% of essence and the balance of water.
In some preferred embodiments, the mass ratio of tranexamic acid to niacinamide is 0.5-3: 1; preferably 1-2: 1; preferably 1: 1.
In other preferred embodiments, the mass ratio of the mixture of candelilla wax/jojoba/rice bran polyglycerol-3 esters, glyceryl stearate, cetearyl alcohol and sodium stearoyl lactylate to the mixture of jojoba esters, cercis chinensis wax, sunflower seed wax and polyglycerol-3 is 0.2-5: 1; preferably 0.5-4: 1; preferably in the range of 0.8 to 3: 1; further preferably 1-2: 1; still more preferably 1: 1.
In other preferred embodiments, the mass ratio of β -glucan to TREMELLA FUCIFORMIS (tremela FUCIFORMIS) fruiting body extract is 1-1.5: 1; preferably 1-1.4: 1; more preferably 1-1.3: 1; further preferably 1-1.2: 1; still more preferably 1-1.1: 1.
The invention also provides a preparation method of the moisturizing and freckle-removing cream containing the beta-glucan, which comprises the following steps:
(1) adding betaine, glycerol, 1, 2-pentanediol, biogan-1, water, glycerol, a mixture of acrylic acid/MA copolymer sodium and propylene glycol, tranexamic acid, nicotinamide, allantoin, beta-glucan, tremella fruiting body extract, sodium polyglutamate, sodium hyaluronate, acryloyl dimethyl ammonium taurate/VP copolymer, carboxymethyl chitosan, xanthan gum and water which are used according to the formula amount into an emulsifying device, uniformly stirring, heating to 85-95 ℃, and keeping the temperature and stirring for 20-40 minutes to obtain a mixture A;
(2) adding hydrogenated polyisobutene, isostearyl isostearate, candelilla wax/jojoba/rice bran polyglycerol-3 esters, glyceryl stearate, a mixture of cetyl stearyl alcohol and sodium stearyl lactylate, jojoba esters, cercis green flower wax, a mixture of sunflower seed wax and polyglycerol-3, pentaerythritol tetra (ethyl hexanoate), propyl heptyl caprylate, behenyl alcohol, polydimethylsiloxane glyceryl stearate, a mixture of PEG-100 glyceryl stearate, shea butter, phytosterol/octyldodecanol lauroyl glutamate, glyceramide ethanol methacrylate/stearyl alcohol methacrylate copolymer, tocopherol acetate and stearic acid into a dissolving device, heating to 80-90 ℃, dissolving and stirring uniformly, keeping the temperature for 10-20 minutes, obtaining a mixture B;
(3) transferring the mixture B into an emulsifying device, mixing with the mixture A, stirring uniformly, continuing to stir for 10-30 minutes at a constant temperature, and cooling to obtain a mixture C;
(4) and when the temperature of the mixture C is reduced to 40-50 ℃, adding 1, 3-propylene glycol, preservative, p-hydroxyacetophenone, yeast peptide, membrane-covered yeast fermentation product filtrate, rice fermentation product filtrate, snow lotus fermentation liquid, medicinal rhubarb extract, nano-encapsulated ceramide and essence into an emulsifying device to be mixed with the mixture C, stirring for 10-30 minutes, continuously reducing the temperature to 35-40 ℃, and filtering and discharging the material to obtain the finished product of the water replenishing and freckle removing cream containing beta-glucan.
Compared with the prior art, the invention has the beneficial effects that:
(1) according to the invention, a certain content of natural plant components, namely, fruit fat of Butyrospermum parkii (I) and fruit body extract of Tremella FUCIFORMIS (Tremella FUCIFORMIS), are added into the cream, and the prepared water-replenishing and freckle-removing cream has excellent water-replenishing performance by controlling the mass ratio of beta-glucan to the fruit body extract of Tremella FUCIFORMIS (Tremella FUCIFORMIS) in the implementation process, so that the skin darkness can be obviously improved, and color spots can be reduced;
(2) the prepared cream has high stability by controlling the mass ratio of tranexamic acid to nicotinamide, and the cream does not have the phenomenon of cream layering or grease separation after being placed for a long time, so that the service life of the cream is effectively prolonged;
(3) according to the invention, the mass ratio of the mixture of candelilla wax/jojoba/rice bran polyglycerol-3 esters, glyceryl stearate, cetostearyl alcohol and sodium stearoyl lactylate to the mixture of the jojoba esters, the cercis chinensis wax, the sunflower seed wax and the polyglycerol-3 is controlled, so that the prepared face cream is more favorable for absorption, is not greasy, has long-term water locking performance, and does not irritate the skin after long-term use;
(4) the formula of the freckle removing cream disclosed by the invention is added with the yeast peptide, the rice fermentation product filtrate and the saussurea involucrate fermentation liquid, which are prepared by a microbial fermentation process, are natural, organic, efficient, healthy and safe freckle-removing components, have high safety, and can effectively resist skin melanin, dullness, color spots and roughness.
Detailed Description
The advantageous effects of the present invention are further described by the following examples, which are for illustrative purposes only and do not limit the scope of the present invention, and variations and modifications obvious to those skilled in the art according to the present invention are included in the scope of the present invention, and the following components are calculated in parts by weight unless otherwise specified.
The ingredients of EMULIUM KAPPA 2 mentioned in the following examples are a mixture of candelilla wax/jojoba/rice bran polyglycerin-3 esters, glyceryl stearate, cetyl stearyl alcohol and sodium stearoyl lactylate in a mass ratio of 30:30:20: 20;
the Acticire components have a mass ratio of 60: 4: 32: 4, a mixture of jojoba esters, cercis green (ACACIA DECURRENS) flower wax, sunflower (helioanthus ANNUUS) seed wax, and polyglycerol-3;
the fermentation broth of herba Saussureae Involueratae is a mixture of yeast fermentation filtrate and herba Saussureae Involueratae (SAUSSUREA INVOLUCRATA) extract at a mass ratio of 99: 1;
the nano-encapsulated ceramide is a mixture of ceramide 3, water, caprylic/capric triglyceride, glycerol, ceteareth-20, polyglycerol-10 stearate and polysorbate-20 in a mass ratio of 5:40:3:25:15:10: 2;
the preservative comprises the mixture of phenoxyethanol, decanediol and caprylyl glycol in a mass ratio of 92:4: 4;
the DERMANOL D is a mixture of water, glycerol, acrylic acid/MA copolymer sodium and butanediol with a mass ratio of 50:25:20: 5;
the GMS/ARLACEL 170 is a mixture of 65:35 glyceryl stearate and PEG-100 glyceryl stearate by mass ratio.
Hydrogenated polybutene mentioned in the examples below is obtained from lappacon usa, 1, 3-propanediol from dupont usa, isostearyl isostearate from dobbo france, DUB ISIS, EMULIUM KAPPA 2 from garfa france, betaine from dupont usa, BP 20, actire from garfa france, pentaerythritol tetrakis (ethyl hexanoate) from japanese white, salocs 5408, propylheptyl octanoate from basf germany, SENSOFT, glycerol from masamil, 1, 2-pentanediol from beixin germany, Sendiol PG, bioglycan-1 from garcinia france, F1000, DERMANOL D from taiwan wisdom, syneresis from gunfango, trandolite, tranexamic acid, notoriocin, yeast peptide from yeast, yeast strain from yeast strain, yeast strain from saqin, the trade name is tectorial membrane yeast fermentation product filtrate, the rice fermentation product filtrate is purchased from Chongyasu, the trade name is holoenzyme, the saussurea involucrate fermentation liquid is purchased from Hubei Angel yeast, the model is FS002, the behenyl alcohol is purchased from German Basff, the model is Lanete 22, the polydimethylsiloxane is purchased from Dow Corning, the model is PMX-200, the nicotinamide is purchased from Dusmann, the model is Niacinamide PC, the beta-glucan is purchased from Ningpo Hippocampus, the trade name is beta-glucan, the GMS/ARLACEL 170 is purchased from British grass, the fruit fat of Butyrosum Park TYK is purchased from Sweden AAK, the model is LIPEEX SHEA, the phytosterol/lauryl lauroyl glutamate is purchased from Japanese gourmet, the model is ELDEW PS-20, the glycerylamide ethanol methacrylate/stearyl alcohol methacrylate copolymer is purchased from Japan Nissian, type Ceracute L, extract of Rheum OFFICINALE (Rheum OFFICINALE) from Chongqingyasu, trade name: dahuang enzyme, nano-encapsulated ceramide available from Korea fighting mountain, model HydroCeramide5, tocopheryl acetate available from Pasteur, Germany, under the trade name vitamin E acetate, ALLANTOIN available from Laine, Switzerland, model ALLANTOIN, Tremella (TREELLA FUCIFORMIS) fruiting body extract available from Ningbo Cinobio, sodium polyglutamate available from Wuhanjunan, trade name poly-gamma-sodium glutamate, sodium hyaluronate available from Shandong Furuida, model HA-TLM 20-40, ammonium acryloyldimethyltaurate/VP copolymer available from Switzerland, model Aristoflex AVC, stearic acid available from Pasteur, model ST05MMY, carboxymethyl chitosan available from Shanghai Chunlun, model MHA micro, p-hydroxyacetophenone was purchased from carnation, de germany, under the trade name carnanoketone, xanthan gum was purchased from sbikac, usa, under the model keldet, and essence was purchased from chang gouwa, japan.
The instrument homogenizer used in the following examples was purchased from IKA, germany, model T25; the stirrer was purchased from IKA, Germany, and the model number is RW 20; the electronic scale is purchased from a normal-maturing Shuangjie, and the model is 1000 g; the pH meter is purchased from Mettler & Toriduo Switzerland and is of the type FE 28; the constant temperature water bath kettle is purchased from Shanghai Bo Xuan with the model number of HHS-11-1; the water purifier is purchased from Qin Yuan Zhejiang and has the model of RO-1851; beaker was purchased from Sichuan glass 500 mL.
Examples 1 to 5A moisturizing and spot-removing cream containing beta-glucan
The preparation method comprises the following steps: the method specifically comprises the following steps:
(1) adding betaine, glycerol, 1, 2-pentanediol, bioglycan-1, DERMANOL D, tranexamic acid, nicotinamide, allantoin, beta-glucan, Tremella (Tremella FUCIFORMIS) fruiting body extract, sodium polyglutamate, sodium hyaluronate, ammonium acryloyldimethyl taurate/VP copolymer, carboxymethyl chitosan, xanthan gum and water into an emulsifying device according to formula dosage, stirring uniformly, heating to 90 ℃, keeping the temperature and stirring for 30 minutes to obtain a mixture A;
(2) adding hydrogenated polyisobutene, isostearyl isostearate, EMULIUM KAPPA 2, acticore, pentaerythritol tetra (ethyl hexanoate) ester, propylheptyl caprylate, behenyl alcohol, polydimethylsiloxane, CMS/ARLACEL 170, Butyrospermum parkii (I) fruit fat, phytosterol/octyldodecanol lauroyl glutamate, glyceramide ethanol methacrylate/stearyl alcohol methacrylate copolymer, tocopherol acetate and stearic acid which are used according to the formula amount into a dissolving device, heating to 85 ℃, dissolving and uniformly stirring the raw materials, and then keeping the temperature for 15 minutes to obtain a mixture B;
(3) transferring the mixture B into an emulsifying device, mixing with the mixture A, stirring uniformly, continuing to stir for 20 minutes at a constant temperature, and cooling to obtain a mixture C;
(4) when the temperature of the mixture C is reduced to 45 ℃, adding 1, 3-propylene glycol, preservative, p-hydroxyacetophenone, yeast peptide, membrane-covered yeast fermentation product filtrate, rice fermentation product filtrate, snow lotus fermentation liquor, rhubarb (RHEUM OFFICINALE) extract, nano-encapsulated ceramide and essence into an emulsifying device to be mixed with the mixture C, stirring for 10-30 minutes, continuously reducing the temperature to 38 ℃, filtering and discharging the materials to obtain the finished product of the moisturizing cream containing beta-glucan for removing freckles.
Comparative examples 1 to 4A moisturizing and spot-removing cream containing beta-glucan
The preparation method is the same as the embodiment.
Comparative example 1 differs from example 1 in that: comparative example 1 without EMULIUM KAPPA 2;
comparative example 2 differs from example 1 in that: comparative example 2 no acticore was added;
comparative example 3 differs from example 1 in that: comparative example 3 No rice fermentation product filtrate, snow lotus fermentation broth and yeast peptide were added;
comparative example 4 differs from example 1 in that: comparative example 4 no nicotinamide or tranexamic acid was added;
comparative examples 5 to 9A moisturizing and spot-removing cream containing beta-glucan
Comparative example 5 differs from example 1 in that: in the comparative example 5, the mass ratio of the tranexamic acid to the nicotinamide is 0.1:1, namely the percentage content of the tranexamic acid in the moisturizing and freckle-removing cream is 0.36 percent, and the percentage content of the nicotinamide is 3.64 percent; the preparation method is the same as the embodiment.
Comparative example 6 differs from example 1 in that: in the comparative example 6, the mass ratio of the tranexamic acid to the nicotinamide is 10:1, that is, the percentage content of the tranexamic acid in the moisturizing and freckle-removing cream is 3.64%, and the percentage content of the nicotinamide is 0.36%; the preparation method is the same as the embodiment.
Comparative example 7 differs from example 1 in that: the mass ratio of EMULIUM KAPPA 2 to acticore in the comparative example 7 is 0.02:1, that is, the EMULIUM KAPPA 2 content in the moisturizing and freckle-removing cream is 0.098%, and the acticore content in the moisturizing and freckle-removing cream is 4.902%; the preparation method is the same as the embodiment.
Comparative example 8 differs from example 1 in that: in the comparative example 8, the mass ratio of EMULIUM KAPPA 2 to acticore is 10:1, that is, the content of EMULIUM KAPPA 2 in the moisturizing and freckle-removing cream is 4.55%, and the content of acticore is 0.45%; the preparation method is the same as the embodiment.
Comparative example 9 differs from example 1 in that: the mass ratio of β -glucan to the extract of the fruit body of TREMELLA FUCIFORMIS (tremela FUCIFORMIS) described in comparative example 9 was 5:1, namely the water replenishing and freckle removing cream has the content of beta-glucan of 0.083 percent and the content of TREMELLA FUCIFORMIS (Tremella FUCIFORMIS) fruiting body extract of 0.017 percent, and the preparation method is the same as the embodiment.
Test evaluation
1. Test of whitening and freckle-removing effects
(1) Experimental population
280 female volunteers of 20-50 years old are selected and randomly and evenly divided into 14 groups of 20.
(2) Laboratory apparatus
German CK multi-probe skin test system MPA9, melanin and heme test probe (Mexamter MX 18).
(3) Experimental methods
After cleaning face, the product is applied on face until absorption, and no cleaning is needed; used 3 times per week for 4 weeks; before testing, the test subjects cleaned their faces with clear water, wiped clean with facial tissue, and started to measure after sitting still in a constant temperature and humidity laboratory (temperature 20. + -. 1 ℃ C., humidity 55. + -. 3) for 30 minutes. A4 x 4cm area in the middle of the right face of each human subject was selected and the average melanin content was measured by a probe at the four corners and in the middle for a total of 5 locations in the area. And then respectively testing the average melanin content of each group of people according to the method on the 7 th, 14 th, 21 th and 28 th days after the water replenishing and freckle removing cream is tried out.
(4) Evaluation method
The skin melanin content is tested by an instrument, and the content is reduced to indicate effectiveness, and the content is increased or unchanged to indicate ineffectiveness.
(5) Results of the experiment
The results for melanin content are shown in Table 1
TABLE 1 results comparing the effects of the products of examples 1-5 with those of comparative examples 1-9
According to the detection data in the table 1, it can be seen that the spot removing cream prepared in the embodiment and the comparative example has the effects of whitening skin and removing spots, and can reduce melanin of skin. However, the skin melanin is reduced more obviously after the freckle-removing cream prepared by the embodiment is used, so that the freckle-removing cream prepared by the embodiment has obvious whitening and freckle-removing effects.
2. Testing of water replenishing effect
(1) Experimental population
280 female volunteers of 20-50 years old are selected and randomly and evenly divided into 14 groups of 20.
(2) Laboratory apparatus
The skin moisture tester Corneometer CM 825 utilizes the characteristic that the dielectric constant of water is far higher than that of other substances, can reflect the moisture content in the skin stratum corneum through determining the capacitance value of skin, and the higher the capacitance value, the higher the stratum corneum moisture content also, vice versa.
(3) Experimental methods
After cleaning face, the product is applied on face until absorption, and no cleaning is needed; used 3 times per week for 4 weeks; before testing, the test subjects cleaned their faces with clear water, wiped clean with facial tissue, and started to measure after sitting still in a constant temperature and humidity laboratory (temperature 20. + -. 1 ℃ C., humidity 55. + -. 3) for 30 minutes. A4 x 4cm area in the middle of the right face of each human subject is selected, and the average capacitance values of the four corners and the middle of the area are tested by a probe for 5 positions in total. And then respectively testing the average capacitance value of each group of people according to the method on the 7 th, 14 th, 21 th and 28 th days after the water replenishing and freckle removing cream is tried out.
(4) Evaluation method
The skin capacitance is tested by the instrument, and if the capacitance is increased, the skin capacitance is effective, and if the capacitance is reduced or unchanged, the skin capacitance is ineffective.
(5) Results of the experiment
The water replenishing effect is shown in Table 2
TABLE 2 comparison of the effects of the products of examples 1-5 with those of comparative examples 1-9
According to the detection data in the table 2, the freckle removing cream prepared by the invention has the moisturizing effect, and can increase the water content of skin. However, the skin water content of the freckle removing cream prepared in the embodiment is increased more obviously after the freckle removing cream is used, so that the freckle removing cream prepared in the embodiment has an obvious moisturizing effect.
3. Product stability testing
Centrifugal investigation: and (3) taking 10g of sample, placing the sample in a centrifugal tube, rotating the sample at 2000r/min for 30min, and observing whether the sample is layered or not.
The freckle removing cream prepared by the invention in the embodiments 1-5 is subjected to a centrifugal investigation test according to the above conditions, and the layering condition of the freckle removing cream is observed.
And (3) stability investigation: the spot removing creams prepared in the embodiments 1-5 and the comparison examples 5-8 of the present invention are respectively put in the environment of 40 ℃ and-15 ℃ for stability test, and are continuously observed for 1 month after being compared and observed once a week (the sample needs to be restored to room temperature for observation again), and then, are observed once a month. And (3) placing for 3 months, and observing the layering condition of the product, wherein the layering condition is that 0 grade is not layered, 1 grade is slight layering and does not influence the use, 2 grade is layering and influences the use, and 3 grade is serious layering and can not be used.
The results of the measurements are shown in Table 3 below
According to the detection results in the above table 3, it can be seen that the contents and mass ratio of nicotinamide and tranexamic acid, and EMULIUM KAPPA 2 and Acticire in the components of the spot removing cream prepared by the present invention obviously affect the stability of the product, and only the spot removing cream prepared by using the components provided by the present invention in the mass ratio range has higher stability.
The above detailed description is specific to possible embodiments of the present invention, and the embodiments are not intended to limit the scope of the present invention, and all equivalent implementations or modifications that do not depart from the scope of the present invention should be included within the scope of the present invention.
Claims (4)
1. The moisturizing and freckle-removing cream containing the beta-glucan is characterized in that: the moisturizing and freckle-removing cream comprises the following components in percentage by weight: 3 to 8 percent of hydrogenated polybutene, 3 to 6 percent of 1, 3-propylene glycol, 2.5 to 3.5 percent of isostearyl isostearate, 2.5 to 3.5 percent of candelilla wax/jojoba/rice bran polyglycerol-3 esters, 2 to 4 percent of glycerol stearate, 2 to 4 percent of mixture of cetostearyl alcohol and sodium stearoyl lactylate, 2 to 4 percent of betaine, 2 to 4 percent of jojoba esters, ceryl green tree flower wax, 2 to 4 percent of mixture of sunflower seed wax and polyglycerol-3, 2 to 4 percent of pentaerythritol tetra (ethyl hexanoate), 2 to 4 percent of caprylic propyl heptyl ester, 2 to 4 percent of glycerol, 2 to 4 percent of 1, 2-pentanediol, 12 to 4 percent of biogum gum, 1.5 to 2.5 percent of mixture of water, glycerol, acrylic acid/maleic acid copolymer sodium and propylene glycol, 1.5 to 2.5 percent of tranexamic acid, 1.5-2.5% of yeast peptide, 1.5-2.5% of tectorial membrane yeast fermentation product filtrate, 1.5-2.5% of rice fermentation product filtrate, 1.5-2.5% of saussurea involucrata fermentation liquid, 1.5-2.5% of behenyl alcohol, 1.5-2.5% of polydimethylsiloxane, 1.5-2.5% of nicotinamide, 1.5-2.5% of mixture of glycerol stearate and PEG-100 glycerol stearate, 1.5-2.5% of shea butter, 1.5-2.5% of phytosterol/octyldodecanol lauroyl glutamate, 1.5-2.5% of glycerylamide ethanol methacrylate/stearyl alcohol methacrylate copolymer, 0.8-1.5% of medicinal rhubarb extract, 0.8-1.5% of nano-encapsulated ceramide, 0.3-0.8% of tocopherol acetate, 0.3-0.8% of allantoin, 0.1-0.2.2% of beta-glucan, 0.08-0.15% of tremella fruiting body extract, 0.08-0.15% of sodium polyglutamate, 0.08-0.15% of sodium hyaluronate, 0.08-0.15% of ammonium acryloyl dimethyl taurate/vinyl pyrrolidone copolymer, 0.08-0.15% of stearic acid, 0.08-0.15% of preservative, 0.08-0.15% of carboxymethyl chitosan, 0.08-0.15% of p-hydroxyacetophenone, 0.08-0.15% of xanthan gum, 0.08-0.15% of essence and the balance of water;
the mass ratio of tranexamic acid to nicotinamide is 0.5-3: 1;
in the mixture of the candelilla wax/jojoba/rice bran polyglycerol-3 esters, the glyceryl stearate, the cetearyl alcohol and the sodium stearoyl lactylate, the mass ratio of the candelilla wax/jojoba/rice bran polyglycerol-3 esters to the glyceryl stearate, the cetearyl alcohol and the sodium stearoyl lactylate is 30:30:20: 20;
the weight ratio of the jojoba esters to the green wattle flower wax to the sunflower seed wax to the polyglycerol-3 in the mixture of the jojoba esters to the green wattle flower wax to the sunflower seed wax to the polyglycerol-3 is 60: 4: 32: 4;
the mass ratio of the mixture of candelilla wax/jojoba/rice bran polyglycerol-3 esters, glyceryl stearate, cetostearyl alcohol and sodium stearoyl lactylate to the mixture of jojoba esters, cercis chinensis wax, sunflower seed wax and polyglycerol-3 is 0.2-5: 1; the saussurea involucrate fermentation liquor is a mixture of yeast fermentation product filtrate and saussurea involucrate extract in a mass ratio of 99: 1;
the mass ratio of the glyceryl stearate to the PEG-100 glyceryl stearate in the mixture of the glyceryl stearate and the PEG-100 glyceryl stearate is 65: 35;
the preservative is a mixture of phenoxyethanol, decanediol and caprylyl glycol in a mass ratio of 92:4: 4;
the mass ratio of water to glycerin to the mixture of water, glycerin, acrylic acid/maleic acid copolymer sodium and propylene glycol is 50:25:20: 5;
the nano-encapsulated ceramide is a mixture of ceramide 3, water, caprylic/capric triglyceride, glycerol, ceteareth-20, polyglycerol-10 stearate and polysorbate-20 in a mass ratio of 5:40:3:25:15:10: 2.
2. The moisturizing and freckle-removing cream containing beta-glucan according to claim 1, wherein the moisturizing and freckle-removing cream comprises: the mass ratio of tranexamic acid to nicotinamide is 1-2: 1.
3. The moisturizing and freckle-removing cream containing beta-glucan according to claim 1, wherein the moisturizing and freckle-removing cream comprises: the mass ratio of the beta-glucan to the tremella fruiting body extract is 1-1.5: 1.
4. a method for preparing a moisturizing and freckle-removing cream containing beta-glucan according to any one of claims 1 to 3, wherein the moisturizing and freckle-removing cream comprises the following steps: the method specifically comprises the following steps:
(1) uniformly mixing betaine, glycerol, 1, 2-pentanediol, biogan-1, water, glycerol, a mixture of acrylic acid/maleic acid copolymer sodium and propylene glycol, tranexamic acid, nicotinamide, allantoin, beta-glucan, tremella fruiting body extract, sodium polyglutamate, sodium hyaluronate, acryloyl dimethyl ammonium taurate/vinyl pyrrolidone copolymer, carboxymethyl chitosan, xanthan gum and water according to formula dosage, and heating and emulsifying to obtain a mixture A;
(2) uniformly mixing hydrogenated polyisobutene, isostearyl isostearate, candelilla wax/jojoba/rice bran polyglycerol-3 esters, glyceryl stearate, a mixture of cetyl stearyl alcohol and sodium stearyl lactylate, jojoba esters, cercis chinensis wax, a mixture of sunflower seed wax and polyglycerol-3, pentaerythritol tetra (ethyl hexanoate), propyl heptyl caprylate, behenyl alcohol, polydimethylsiloxane, glyceryl stearate, a mixture of PEG-100 glyceryl stearate, shea butter, phytosterol/octyldodecanol lauroyl glutamate, glyceramide ethanol methacrylate/stearyl alcohol methacrylate copolymer, tocopherol acetate and stearic acid according to formula dosage, and heating and stirring until the mixture is dissolved to obtain a mixture B;
(3) mixing the mixture B with the mixture A, and uniformly stirring to obtain a mixture C;
(4) when the mixture C is cooled to 40-50 ℃, adding 1, 3-propylene glycol, preservative, p-hydroxyacetophenone, yeast peptide, membrane-covered yeast fermentation product filtrate, rice fermentation product filtrate, snow lotus fermentation liquid, medicinal rhubarb extract, nano-encapsulated ceramide and essence according to the formula dosage, and uniformly stirring to obtain the finished product of the moisturizing and freckle removing cream.
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