CN112618422A - Composite whitening composition, preparation method and application - Google Patents
Composite whitening composition, preparation method and application Download PDFInfo
- Publication number
- CN112618422A CN112618422A CN202011555127.1A CN202011555127A CN112618422A CN 112618422 A CN112618422 A CN 112618422A CN 202011555127 A CN202011555127 A CN 202011555127A CN 112618422 A CN112618422 A CN 112618422A
- Authority
- CN
- China
- Prior art keywords
- whitening composition
- composite whitening
- ganoderma lucidum
- composite
- sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000002087 whitening effect Effects 0.000 title claims abstract description 71
- 239000000203 mixture Substances 0.000 title claims abstract description 53
- 239000002131 composite material Substances 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 240000008397 Ganoderma lucidum Species 0.000 claims abstract description 36
- 235000001637 Ganoderma lucidum Nutrition 0.000 claims abstract description 36
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- 229940033280 alpha-arbutin Drugs 0.000 claims abstract description 27
- 239000000047 product Substances 0.000 claims description 23
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 15
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- 238000003756 stirring Methods 0.000 claims description 12
- 238000001816 cooling Methods 0.000 claims description 10
- -1 glycerol glucoside Chemical class 0.000 claims description 10
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 9
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to the field of skin care products, and particularly discloses a composite whitening composition, a preparation method and application thereof, wherein the composite whitening composition comprises the following components in percentage by mass: ganoderma lucidum stem extract: 0.5 to 5.0 percent; alpha-arbutin: 0.5 to 3.0 percent. According to the invention, the ganoderma lucidum stem extract and the alpha-arbutin are reasonably mixed according to a specific proportion to obtain the composite whitening composition, the moisturizing capability and the anti-inflammatory effect of the ganoderma lucidum stem extract are combined, the whitening effect of the alpha-arbutin can be enhanced, and compared with the whitening composition prepared by only adding the alpha-arbutin, the composite whitening composition has more excellent whitening effect and simultaneously has the moisturizing capability and the anti-inflammatory effect.
Description
Technical Field
The invention relates to the field of skin care products, in particular to a composite whitening composition, a preparation method and application.
Background
Skin whitening is a permanent topic and pursuit of vast women who love beauty. The research and development, safety and efficacy evaluation of whitening skin care products naturally become the focus of attention of researchers, production operators and consumers. The color of the skin is mainly determined by the skin pigment content and distribution, with melanin being the most dominant determinant. Melanocytes in the skin produce melanin, melanin granules are transferred to keratinocytes through melanocyte dendrites, and the melanin granules transferred to the keratinocytes ascend to the stratum corneum along with epidermal cells, thereby affecting the color of the skin or forming color spots, and finally being excreted along with the shedding of the stratum corneum.
In addition, the irradiation of ultraviolet rays also changes melanin to generate a substance for protecting the skin, and then the melanin moves layer by layer through cell metabolism to reach the skin epidermis, so that the skin problems such as color spots, uneven skin color and the like seen by people are formed.
At present, the general skin whitening agent mainly inhibits the activity of tyrosinase in the skin through alpha-arbutin, blocks the formation of melanin, and accelerates the decomposition and excretion of the melanin through the direct combination of the alpha-arbutin and the tyrosinase, thereby reducing the pigmentation of the skin and removing stains and freckles. However, as the demand for whitening effects by beauty-conscious people becomes higher, the whitening agent prepared only from α -arbutin has not been able to satisfy the demand for whitening effects by beauty-conscious people, and thus how to provide a whitening composition having a remarkable whitening effect is a technical problem that needs to be solved.
Disclosure of Invention
The first object of the present invention is to provide a composite whitening composition to solve the problem that the whitening effect of the skin whitening agents currently on the market is not obvious.
In order to achieve the purpose, the invention adopts the following technical scheme:
a composite whitening composition, comprising by mass percent: ganoderma lucidum stem extract: 0.5 to 5.0 percent;
alpha-arbutin: 0.5 to 3.0 percent;
the preparation method of the ganoderma lucidum stem extract comprises the following steps:
the method comprises the following steps: spreading Ganoderma in sterilized stainless steel tray, and air drying in ventilated and dry place for 1-2 days;
step two: crushing the air-dried ganoderma lucidum in the step one into 1-2 cm-large fragments by using a crusher;
step three: adding ganoderma lucidum, ethanol and water in a weight ratio of 1:2:1 into a stainless steel heating reflux pot, starting heating, setting the temperature to 98 ℃, refluxing and cooking for 2 hours, then cooling, naturally cooling to 50 ℃, filtering, pouring out a first decoction, remaining residues in the pot, repeating the decoction steps in the third step, pouring out a second decoction, and combining the first and second decoctions to obtain an extracting solution.
Step four: filtering the above extractive solution with 200 mesh clean gauze, transferring the filtrate into rotary evaporator, vacuumizing, distilling at 62 deg.C, adding butanediol equivalent to the filtrate when the filtrate is distilled to 20%, and stirring to obtain mixed solution.
Step five: transferring the mixed liquid obtained in the step four to a rotary evaporator in batches, vacuumizing, setting the temperature to 58 ℃, and continuously steaming the residual ethanol to obtain the ganoderma lucidum stem extract.
Further, the composite whitening composition further comprises an emulsifier, wherein the emulsifier comprises one or more of polyglycerol-10 dipalmitate, hydrogenated lecithin, steareth-2, steareth-21, potassium cetyl phosphate, ceteareth-20, glyceryl stearate, methylglucose sesquistearate, PEG-20 methylglucose sesquistearate, polysorbate-60, polysorbate-20, PEG-40 hydrogenated castor oil.
Further, the composite whitening composition also comprises a thickening agent, wherein the thickening agent comprises one or more of hydroxyethyl cellulose, carbomer, xanthan gum, sodium acrylate/sodium acryloyldimethyl taurate copolymer, polyacrylate cross-linked polymer-6, ammonium acryloyldimethyl taurate/VP copolymer, ammonium acryloyldimethyl taurate/behenyl polyether-25 methacrylate cross-linked polymer, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, tamarind seed polysaccharide, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and agarose.
Further, the composite whitening composition further comprises an emollient including one or more of cetostearyl alcohol, squalane, hydrogenated polydecene, neopentyl glycol diheptanoate, ethylhexyl palmitate, polydimethylsiloxane, cyclomethicone, octyl methicone, triglyceride, pentaerythritol tetraester, isononyl isononanoate, mineral oil, prinsepia utilis royle oil, octyl dodecanol, jojoba seed oil, grape seed oil, isopropyl myristate, phenyl methicone, shea butter.
Further, the composite whitening composition also comprises a humectant, wherein the humectant comprises one or more of glycerin, butanediol, 1, 3-propylene glycol, betaine, dipropylene glycol, glyceryl polyether-26, erythritol, methyl propylene glycol, hydroxyethyl urea, sodium polyglutamate, bis-PEG-18 methyl ether dimethylsilane, panthenol, levan and trehalose.
Further, the composite whitening composition also comprises a skin conditioner, wherein the skin conditioner comprises one or more of bisabolol, tocopherol, beta-glucan, nicotinamide, biogum-1, sodium polyaspartate, glycerol glucoside, dipotassium glycyrrhizinate, glutathione, matrine, corn gluten amino acids, purslane extract, carnosine, acetyl chitosamine, madecassoside, sodium polyglutamate, lactobacillus fermentation lysate and aloe vera leaf juice.
Further, the composite whitening composition also comprises a pH regulator, wherein the pH regulator comprises one or more of triethanolamine, potassium hydroxide, arginine, sodium hydroxide, citric acid and sodium citrate.
Further, the compound whitening composition also comprises an antiseptic, wherein the antiseptic comprises one or more of methyl hydroxybenzoate, propyl hydroxybenzoate, chlorphenesin, phenoxyethanol, ethylhexyl glycerol, hexamidine dihydrochloride and benzyl alcohol.
A second object of the present invention is to provide a method for preparing the composite whitening composition as described above, which includes a step of mixing the components of the composite whitening composition.
The third purpose of the present invention is to provide a use of the composite whitening composition as described above in skin care products, including aqueous type skin care products, gel type skin care products, emulsion type skin care products or cream type skin care products.
The invention has the beneficial effects that:
the invention provides a composite whitening composition, which comprises the following components in percentage by mass: ganoderma lucidum stem extract: 0.5 to 5.0 percent; alpha-arbutin: 0.5 to 3.0 percent. According to the invention, the ganoderma lucidum stem extract and the alpha-arbutin are reasonably mixed according to a specific proportion to obtain the composite whitening composition which can be applied to cosmetics. The alpha-arbutin can rapidly permeate into skin, effectively inhibit the activity of tyrosinase in the skin and block the formation of melanin while not influencing the cell proliferation concentration, and the decomposition and excretion of the melanin are accelerated by directly combining the alpha-arbutin with the tyrosinase, so that the skin pigmentation is reduced, and color spots and freckles are removed. The ganoderma lucidum stem extract is rich in active polysaccharide, ganoderma lucidum polypeptide, triterpenes, 16 amino acids, various trace elements and the like, can resist inflammation and aging, has an inhibiting effect on tyrosinase, has a good whitening effect, combines the moisturizing capability and the anti-inflammatory effect, and can enhance the whitening effect of alpha-arbutin.
Detailed Description
The invention provides a whitening cosmetic composition and a preparation method and application thereof. In order that the invention may be more readily understood, reference will now be made to the following more particular description of the invention, examples of which are set forth below. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. These embodiments are provided so that this disclosure will be thorough and complete. The various starting materials used in the examples are, unless otherwise indicated, conventional commercial products.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
The numerical values set forth in the examples of the present invention are approximations, not necessarily values. All values within the error range may be included without limiting to the specific values disclosed in the embodiments of the present invention, where the error or experimental conditions allow.
The numerical ranges disclosed in the examples of the present invention are intended to indicate the relative amounts of the components in the mixture and the ranges of temperatures or other parameters recited in the other method examples.
The invention provides a composite whitening composition, which comprises the following components in percentage by mass:
ganoderma lucidum stem extract: 0.5 to 5.0 percent;
alpha-arbutin: 0.5 to 3.0 percent.
In this embodiment, the composite whitening composition includes ganoderma lucidum stem extract and alpha-arbutin.
Wherein, the GANODERMA LUCIDUM (GANODERMA LUCIDUM) stem extract is rich in active polysaccharide, GANODERMA LUCIDUM polypeptide, triterpenes, 16 amino acids (containing seven essential amino acids for human bodies), various trace elements and the like, the GANODERMA LUCIDUM stem extract not only has the effects of moisturizing, anti-inflammation, anti-aging and inhibiting tyrosinase, but also has good whitening effect, and the preparation of whitening cosmetics by using the GANODERMA LUCIDUM stem extract is not reported at present.
The preparation method of the ganoderma lucidum stem extract comprises the following steps:
the method comprises the following steps: spreading Ganoderma in sterilized stainless steel tray, and air drying in ventilated and dry place for 1-2 days;
step two: crushing the air-dried ganoderma lucidum in the step one into 1-2 cm-large fragments by using a crusher;
step three: adding ganoderma lucidum, ethanol and water in a weight ratio of 1:2:1 into a stainless steel heating reflux pot, starting heating, setting the temperature to 98 ℃, refluxing and cooking for 2 hours, then cooling, naturally cooling to 50 ℃, filtering, pouring out a first decoction, remaining residues in the pot, repeating the decoction steps in the third step, pouring out a second decoction, and combining the first and second decoctions to obtain an extracting solution.
Step four: filtering the above extractive solution with 200 mesh clean gauze, transferring the filtrate into rotary evaporator, vacuumizing, distilling at 62 deg.C, adding butanediol equivalent to the filtrate when the filtrate is distilled to 20%, and stirring to obtain mixed solution.
Step five: transferring the mixed liquid obtained in the step four to a rotary evaporator in batches, vacuumizing, setting the temperature to 58 ℃, and continuously steaming the residual ethanol to obtain the ganoderma lucidum stem extract.
The alpha-arbutin can rapidly permeate into skin, can effectively inhibit the activity of tyrosinase in the skin and block the formation of melanin while not influencing the cell proliferation concentration, and accelerates the decomposition and excretion of the melanin by directly combining the alpha-arbutin with the tyrosinase, thereby reducing the skin pigmentation and removing stains and freckles.
In a further embodiment of the present invention, the composite whitening composition further comprises 0.1-5.0% of an emulsifier comprising one or more of polyglyceryl-10 dipalmitate, hydrogenated lecithin, steareth-2, steareth-21, potassium cetyl phosphate, ceteth-20, glyceryl stearate, methylgluco-sesquistearate, PEG-20 methylgluco-sesquistearate, polysorbate-60, polysorbate-20, PEG-40 hydrogenated castor oil.
In a further embodiment of the present invention, the composite whitening composition further comprises 0.1-2.0% of a thickener comprising one or more of hydroxyethylcellulose, carbomer, xanthan gum, sodium acrylate/sodium acryloyldimethyl taurate copolymer, polyacrylate crosspolymer-6, ammonium acryloyldimethyl taurate/VP copolymer, ammonium acryloyldimethyl taurate/behenyl polyether-25 methacrylate crosspolymer, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, tamarind seed polysaccharide, acrylic acid (ester)/C10-30 alkanol acrylate crosspolymer, agarose.
In a further embodiment of the present invention, the composite whitening composition further comprises 1.0-30.0% of an emollient comprising one or more of cetostearyl alcohol, squalane, hydrogenated polydecene, neopentyl glycol diheptanoate, ethylhexyl palmitate, polydimethylsiloxane, cyclomethicone, octyl methicone, triglycerides, pentaerythritol tetraester, isononyl isononanoate, mineral oil, prinsepia utilis royle oil, octyl dodecanol, jojoba seed oil, grape seed oil, isopropyl myristate, phenyl methicone, shea butter.
In a further embodiment of the present invention, the composite whitening composition further comprises 5.0-20.0% of a humectant, wherein the humectant comprises one or more of glycerin, butylene glycol, 1, 3-propylene glycol, betaine, dipropylene glycol, glyceryl polyether-26, erythritol, methyl propylene glycol, hydroxyethyl urea, sodium polyglutamate, bis-PEG-18 methyl ether dimethylsilane, panthenol, levan, and trehalose.
In a further embodiment of the present invention, the composite whitening composition further comprises 3.0-10.0% of a skin conditioner comprising one or more of bisabolol, tocopherol, β -glucan, niacinamide, biosaccharide-1, sodium polyaspartate, glycerol glucoside, dipotassium glycyrrhizinate, glutathione, matrine, corn gluten amino acids, purslane extract, carnosine, acetyl chitosamine, madecassoside, sodium polyglutamate, lactobacillus fermentation lysate, aloe vera leaf juice.
In a further embodiment of the present invention, the composite whitening composition further comprises 0.1-0.6% of a pH adjusting agent, wherein the pH adjusting agent comprises one or more of triethanolamine, potassium hydroxide, arginine, sodium hydroxide, citric acid, and sodium citrate.
In a further embodiment of the present invention, the composite whitening composition further comprises 0.1-1.0% of a preservative comprising one or more of methylparaben, propylparaben, chlorphenesin, phenoxyethanol, ethylhexylglycerin, hexamidine dihydrochloride, benzyl alcohol.
In a further embodiment of the present invention, the composite whitening composition further comprises a solvent, such as water.
According to the invention, the ganoderma lucidum stem extract and the alpha-arbutin are reasonably mixed according to a specific proportion to obtain the composite whitening composition which can be applied to cosmetics. The alpha-arbutin can rapidly permeate into skin, effectively inhibit the activity of tyrosinase in the skin and block the formation of melanin while not influencing the cell proliferation concentration, and the decomposition and excretion of the melanin are accelerated by directly combining the alpha-arbutin with the tyrosinase, so that the skin pigmentation is reduced, and color spots and freckles are removed. The ganoderma lucidum stem extract is rich in active polysaccharide, ganoderma lucidum polypeptide, triterpenes, 16 amino acids (including seven essential amino acids for human bodies), various trace elements and the like, can resist inflammation and aging, has an inhibiting effect on tyrosinase, has a good whitening effect, combines the moisturizing capability and the anti-inflammatory effect, and can enhance the whitening effect of alpha-arbutin.
The whitening composition provided by the invention can be applied to various product forms of whitening cosmetics, and has the characteristics of simple preparation method, wide application and capability of meeting market demands.
In another aspect, the present invention also provides a method for preparing a composite whitening composition, which includes a step of mixing the components of the composite whitening composition.
The invention also provides application of the composite whitening composition in skin care products, wherein the skin care products comprise aqueous skin care products, gel skin care products, emulsion skin care products or cream skin care products.
DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION
Embodiments of the present invention will be described in detail below with reference to examples 1 to 3 and comparative examples 1 to 3, but those skilled in the art will appreciate that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products commercially available.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
Examples 1 to 3 and comparative examples 1 to 3 provide whitening creams, which comprise the following raw materials in parts by weight as shown in table 1:
TABLE 1
The preparation method comprises the following steps:
(1) accurately weighing various raw materials in the formula, and placing the raw materials in a clean and sterilized vessel;
(2) adding phase A raw materials (water, carbomer, sodium polyglutamate, agarose, methyl hydroxybenzoate, butanediol and glycerol) into a vacuum emulsifying pot, stirring, heating to 80-85 deg.C, stirring, and keeping the temperature for use;
(3) adding phase B raw materials (steareth-2, steareth-21, cetostearyl alcohol, squalane, neopentyl glycol diheptanoate, bisabolol, polydimethylsiloxane and octyl methicone) into an oil pan, stirring and heating to 80-85 ℃, fully and uniformly stirring, and keeping the temperature for later use;
(4) pumping the phase B raw material into a vacuum emulsifying pot, mixing and stirring uniformly, homogenizing and emulsifying for 5-8 minutes, stirring uniformly, stirring at constant temperature for defoaming for 10 minutes, and cooling;
(5) cooling to below 40 deg.C, adding phase C materials (tocopherol (vitamin E), erythritol, arginine, corn gluten amino acids, beta-dextran, Ganoderma lucidum stem extract, and alpha-arbutin), stirring, and cooling;
(6) cooling to below 35 deg.C, adding D phase material (phenoxyethanol), stirring, discharging, and standing;
(7) after the inspection is qualified, filling, packaging and code spraying are carried out;
(8) and warehousing after the inspection is qualified.
Test example I, physical and chemical index detection
The prepared whitening cream is subjected to physicochemical index test according to QB/T1857O/W type. The results are as follows:
1. appearance: white or light yellow cream.
2. pH value: 5.5-6.8.
3. And (3) investigating heat resistance stability: keeping the temperature at (40 +/-1) ℃ for 24h, and ensuring that no obvious character difference exists between the temperature after the temperature is restored to the room temperature and the temperature before the test, so that the product is qualified.
4. And (3) cold resistance stability investigation: keeping the temperature of minus 5 ℃ to minus 10 ℃ for 24h, and having no obvious character difference after the temperature is restored to the room temperature and before the test, and being qualified.
Test example two, application Performance test
1) And (3) product safety test:
the skin care compositions obtained in examples and comparative examples were subjected to a human patch test according to the method described in technical specification for cosmetic safety (2015 edition).
The experimental population is as follows: total 36, 30 women, 6 men, age 21-59, 6 per group, composite subject volunteer enrollment criteria;
the test method comprises the following steps: the selection area is not more than 50mm2A suitable patch tester with a depth of about 1mm, wherein about 0.020-0.025mL of the test substance is added into the patch tester by a closed patch test method; applying the spot tester to the curved side of forearm of subject, and removing the subject 24h laterThe test samples were observed for skin reactions at 0.5, 24, and 48h after removal, and the results were recorded according to the skin reaction grading standard in technical specifications for cosmetic safety (2015).
And (3) test results: the 36 subjects scored 0 at 3 observation time points 0.5h, 24h, 48h after removal of the patch (negative response).
2) And (3) product efficacy test:
test of whitening Effect
(1) Taking the example and comparative example cosmetics;
(2) the test population: 90 testers with average age of 25-35 years; wherein, 35 men and 65 women have no damage to skin health; each example and comparative example had 15 subjects. Selecting the left and right cheekbones of the face of a subject, the left and right cheeks at the intersection of the nose tip and the pupil, and the left and right sides at the intersection of the temple and the mouth corner as test areas;
(3) firstly, a blank value of an experimental part before the cosmetic is applied is measured by a technician by using a skin melanin tester (Mexa meter MX 18) of Germany CK company, five times are measured at each point, and an average value is taken;
(4) the subjects measured the data of the experimental sites using a skin melanin tester (Mexamete r MX 18) five times per spot, and averaged once a day, morning and night, after one, two, three, and four consecutive weeks using the example and comparative cosmetics;
(5) and (4) counting the average value of the values measured at each time of the experimental part of the subject, and analyzing the change rule of the MI value, thereby determining the whitening efficacy of the cosmetics of the examples and the comparative examples.
Test data: after four weeks (28 days) of use of the product, the statistics are shown in table 2:
TABLE 2
Examples are examples in which ganoderma lucidum stem extract and alpha-arbutin were added in different ratios; comparative example 1 was a control blank with alpha-arbutin added, comparative example 2 was a control blank with Ganoderma lucidum stem extract added. As shown in table 2, from the test results, it can be seen that: the melanin value was in a decreasing trend but the decreasing trend was not significant after analysis from the instrumental test data using the comparative example. After the analysis of instrument test data, the reduction of melanin value is obvious after the composition is used for 4 weeks, which shows that the synergistic whitening effect of the ganoderma lucidum stem extract and the alpha-arbutin product is obvious and is obviously better than that of the ganoderma lucidum stem extract or the alpha-arbutin which is used alone.
The above description is only a preferred embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications and equivalents of the present invention, which are made by the present specification and directly/indirectly applied to other related technical fields within the spirit of the present invention are included in the scope of the present invention.
The above description of the embodiments is only intended to facilitate the understanding of the method of the invention and its core idea. It should be noted that, for those skilled in the art, it is possible to make various improvements and modifications to the present invention without departing from the principle of the present invention, and those improvements and modifications also fall within the scope of the claims of the present invention.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (10)
1. A composite whitening composition is characterized by comprising the following components in percentage by mass:
ganoderma lucidum stem extract: 0.5 to 5.0 percent;
alpha-arbutin: 0.5 to 3.0 percent;
the preparation method of the ganoderma lucidum stem extract comprises the following steps:
the method comprises the following steps: spreading Ganoderma in sterilized stainless steel tray, and air drying in ventilated and dry place for 1-2 days;
step two: crushing the air-dried ganoderma lucidum in the step one into 1-2 cm-large fragments by using a crusher;
step three: adding ganoderma lucidum, ethanol and water in a weight ratio of 1:2:1 into a stainless steel heating reflux pot, starting heating, setting the temperature to 98 ℃, carrying out reflux cooking for 2 hours, then cooling, naturally cooling to 50 ℃, filtering, pouring out a first decoction, leaving residues in the pot, repeating the decocting steps in the third step, pouring out a second decoction, and combining the first and second decoctions to obtain an extracting solution;
step four: filtering the extractive solution with 200 mesh clean gauze, transferring the filtrate into a rotary evaporator, vacuumizing, distilling at 62 deg.C, adding butanediol equivalent to the filtrate when the filtrate is distilled to 20%, and stirring to obtain mixed solution;
step five: transferring the mixed liquid obtained in the step four to a rotary evaporator in batches, vacuumizing, setting the temperature to 58 ℃, and continuously steaming the residual ethanol to obtain the ganoderma lucidum stem extract.
2. The composite whitening composition of claim 1, further comprising an emulsifier comprising one or more of polyglyceryl-10 dipalmitate, hydrogenated lecithin, steareth-2, steareth-21, potassium cetylphosphate, ceteth-20, glyceryl stearate, methylglucose sesquistearate, PEG-20 methylglucose sesquistearate, polysorbate-60, polysorbate-20, PEG-40 hydrogenated castor oil.
3. The composite whitening composition of claim 1, further comprising a thickener comprising one or more of hydroxyethylcellulose, carbomer, xanthan gum, sodium acrylate/sodium acryloyldimethyl taurate copolymer, polyacrylate crosspolymer-6, ammonium acryloyldimethyl taurate/VP copolymer, ammonium acryloyldimethyl taurate/behenyl polyether-25 methacrylate crosspolymer, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, tamarind seed polysaccharide, acrylic acid (ester)/C10-30 alkanol acrylate crosspolymer, agarose.
4. The composite whitening composition of claim 1, further comprising an emollient including one or more of cetostearyl alcohol, squalane, hydrogenated polydecene, neopentyl glycol diheptanoate, ethylhexyl palmitate, dimethicone, cyclomethicone, octyl methicone, triglycerides, pentaerythritol tetraester, isononyl isononanoate, mineral oil, prinsepia utilis royle oil, octyl dodecanol, jojoba seed oil, grape seed oil, isopropyl myristate, phenyl methicone, shea butter oil.
5. The composite whitening composition of claim 1, further comprising a humectant including one or more of glycerin, butylene glycol, 1, 3-propylene glycol, betaine, dipropylene glycol, glyceryl polyether-26, erythritol, methyl propylene glycol, hydroxyethyl urea, sodium polyglutamate, bis-PEG-18 methyl ether dimethylsilane, panthenol, levan, trehalose.
6. The composite whitening composition of claim 1, further comprising a skin conditioner comprising one or more of bisabolol, tocopherol, beta-glucan, niacinamide, biosaccharide-1, sodium polyaspartate, glycerol glucoside, dipotassium glycyrrhizinate, glutathione, matrine, corn gluten amino acids, purslane extract, carnosine, acetyl chitosamine, madecassoside, sodium polyglutamate, lactobacillus fermentation lysate, aloe vera leaf juice.
7. The composite whitening composition of claim 1, further comprising a pH adjuster comprising one or more of triethanolamine, potassium hydroxide, arginine, sodium hydroxide, citric acid, and sodium citrate.
8. The composite whitening composition of claim 1, further comprising a preservative comprising one or more of methylparaben, propylparaben, chlorphenesin, phenoxyethanol, ethylhexylglycerin, hexamidine dihydrochloride, benzyl alcohol.
9. A method for preparing the composite whitening composition according to any one of claims 1 to 8, comprising the step of mixing the components of the composite whitening composition.
10. Use of the composite whitening composition according to any one of claims 1 to 8 in skin care products, including aqueous, gel, emulsion or cream type skin care products.
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