CN112618431A - Novel whitening composition, preparation method and application - Google Patents
Novel whitening composition, preparation method and application Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The invention relates to the field of skin care products, and particularly discloses a novel whitening composition, a preparation method and application thereof, wherein the novel whitening composition comprises the following components in percentage by mass: nonapeptide-1 & tetrapeptide-1: 1 to 5 percent; 3-o-ethyl ascorbic acid: 0.5-3%; glutathione & grape fermentation extract: 0.5-1%; centella asiatica extract: 1 to 2 percent; diglucosylgallic acid: 0.5-3%; decarboxylated carnosine: 0.1 to 2 percent. The invention can simultaneously realize the effects of resisting oxidation and saccharification, protecting DNA, inhibiting tyrosinase activity, preventing melanin transfer, reducing inflammatory factor expression and the like, thereby realizing the way of comprehensively blocking or lightening the problem of influencing skin, reducing the probability of the problems of darkness, spots, redness, wax yellowness and the like of the skin, overcoming the one-sidedness of the prior art and further achieving the optimal whitening effect.
Description
Technical Field
The invention relates to the field of skin care products, in particular to a novel whitening composition, a preparation method and application.
Background
The invention discloses a white-masked three-ugly seed, which is a permanent topic, ancient people wash the face with yoghurt, vinasse, rice washing water and fruit juice to achieve the effects of skin brightening and whitening, whitening cosmetics act on the skin to achieve the effects of skin brightening and whitening, the whitening occupies a large share in the cosmetic market, and the whitening cosmetics on the market only aim at one or two paths. Exposure of the skin to UV generates 7 biological pathways: protein and lipid oxidation, production of DNA dimers, activation of melanin production pathway (MITF), melanin synthesis (tyrosinase), melanin transfer into keratinocytes (galactose receiver), production of prostaglandin-2 (PGE2), etc., with the following visible results: dull, blotchy, reddish, yellowish wax, etc.
However, most of the skin whitening agents currently on the market cannot comprehensively block all approaches to skin problems, resulting in poor whitening effects.
Therefore, it is an urgent technical problem to provide a whitening agent that can comprehensively block all the problems affecting the skin and achieve an optimal whitening effect.
Disclosure of Invention
The first object of the present invention is to provide a novel whitening composition to solve the problem that the skin whitening agents currently on the market cannot comprehensively block all the ways of influencing the skin, and achieve the optimal whitening effect.
In order to achieve the purpose, the invention adopts the following technical scheme:
a novel whitening composition comprising, in mass percent: nonapeptide-1 & tetrapeptide-1: 1 to 5 percent; 3-o-ethyl ascorbic acid: 0.5-3%; glutathione & grape fermentation extract: 0.5-1%; centella asiatica extract: 1 to 2 percent; diglucosylgallic acid: 0.5-3%; decarboxylated carnosine: 0.1 to 2 percent.
Further, the novel whitening composition also comprises an aqueous phase component, wherein the aqueous phase component comprises one or more of deionized water, butanediol, glycerol, trehalose, sodium hyaluronate and ammonium acryloyl dimethyl taurate/VP copolymer.
Further, the novel whitening composition also comprises an oil phase component, wherein the oil phase component comprises one or more of polydimethylsiloxane, myristyl myristate, isononyl isononanoate, ethylhexyl palmitate and shea butter.
Further, the novel whitening composition further comprises an emulsifier, wherein the emulsifier comprises one or more of steareth-2, steareth-21, hydrogenated lecithin, glyceryl stearate & PEG-100 stearate.
Further, the novel whitening composition also comprises a humectant which comprises one or more of glycerin, butanediol, 1, 3-propylene glycol, betaine, dipropylene glycol, glyceryl polyether-26, erythritol, methyl propylene glycol, hydroxyethyl urea, sodium polyglutamate, panthenol, levan and trehalose.
Further, the novel whitening composition further comprises a ph regulator, wherein the ph regulator comprises one or more of triethanolamine, potassium hydroxide, arginine, sodium hydroxide, citric acid and sodium citrate.
Further, the novel whitening composition also comprises a thickening agent, wherein the thickening agent comprises one or more of hydroxyethyl cellulose, carbomer, xanthan gum, sodium acrylate/sodium acryloyldimethyl taurate copolymer, polyacrylate cross-linked polymer-6, ammonium acryloyldimethyl taurate/behenyl polyether-25 methacrylate cross-linked polymer, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, tamarind seed polysaccharide, carrageen powder and agarose.
Further, the novel whitening composition further comprises a preservative, wherein the preservative comprises one or more of methyl hydroxybenzoate, propyl hydroxybenzoate, chlorphenesin, phenoxyethanol, ethylhexyl glycerol, hexamidine dihydrochloride and benzyl alcohol.
A second object of the present invention is to provide a method for preparing the novel whitening composition as described above, which comprises the step of mixing the components of the novel whitening composition.
The third purpose of the present invention is to provide the use of the novel whitening composition as described above in skin care products, including aqueous type skin care products, gel type skin care products, emulsion type skin care products or cream type skin care products.
The invention has the beneficial effects that:
the invention provides a novel whitening composition, which comprises the following components in percentage by mass: nonapeptide-1 & tetrapeptide-1: 1 to 5 percent; 3-o-ethyl ascorbic acid: 0.5-3%; glutathione & grape fermentation extract: 0.5-1%; centella asiatica extract: 1 to 2 percent; diglucosylgallic acid: 0.5-3%; decarboxylated carnosine: 0.1 to 2 percent. The novel whitening composition is formed by combining nonapeptide-1 & tetrapeptide-1, 3-o-ethyl ascorbic acid, glutathione & grape fermentation extract, centella asiatica extract, diglucosylgallic acid and decarboxylated carnosine, and can simultaneously realize the effects of resisting oxidation and saccharification, protecting DNA, inhibiting tyrosinase activity, preventing melanin transfer, reducing inflammatory factor expression and the like, thereby realizing the way of comprehensively blocking or reducing the problem affecting the skin, reducing the probability of the problems of darkness, spots, reddening, wax yellow and the like of the skin, and overcoming the one-sidedness of the prior art, thereby achieving the optimal whitening effect.
Detailed Description
The invention provides a whitening cosmetic composition and a preparation method and application thereof. In order that the invention may be more readily understood, reference will now be made to the following more particular description of the invention, examples of which are set forth below. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. These embodiments are provided so that this disclosure will be thorough and complete. The various starting materials used in the examples are, unless otherwise indicated, conventional commercial products.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
The numerical values set forth in the examples of the present invention are approximations, not necessarily values. All values within the error range may be included without limiting to the specific values disclosed in the embodiments of the present invention, where the error or experimental conditions allow.
The numerical ranges disclosed in the examples of the present invention are intended to indicate the relative amounts of the components in the mixture and the ranges of temperatures or other parameters recited in the other method examples.
The invention provides a novel whitening composition, which comprises the following components in percentage by mass: nonapeptide-1 & tetrapeptide-1: 1 to 5 percent; 3-o-ethyl ascorbic acid: 0.5-3%; glutathione & grape fermentation extract: 0.5-1%; centella asiatica extract: 1 to 2 percent; diglucosylgallic acid: 0.5-3%; decarboxylated carnosine: 0.1 to 2 percent.
In this example, the novel whitening composition includes nonapeptide-1 & tetrapeptide-1, 3-o-ethyl ascorbic acid, glutathione & grape fermentation extract, centella asiatica extract, diglucosylgallic acid, and decarboxylated carnosine.
Wherein, the nonapeptide-1 and the tetrapeptide-1 are combined with a receptor MCR-1 thereof through competitive antagonism of a natural ligand alpha-MSH, thereby blocking tyrosinase from being activated, reducing melanin generation and preventing excessive melanin generation. The o-ethyl ascorbic acid enters the dermis through the horny layer and is decomposed by biological enzymes in vivo so as to exert the activity of the vitamin C for inhibiting tyrosinase, and the polymerization of melanin monomers in the melanin protogenesis path. The glutathione & grape fermentation extract can remove free radicals and slow down the speed of protein denaturation, lipid oxidation and enzyme catalysis. The glutathione and grape fermentation extract is compounded with the VC derivative, so that the whitening effect is doubled. The herba Centellae extract can reduce the generation of inflammation mediators (IL-1, MMP-1), improve and repair skin barrier, promote the growth of collagen synthetic fibroblast, reduce pigmentation, repair suntan skin, and lighten pigment scar. Diglucosylgallic acid has strong antioxidant effect, and can reduce free radical generation, prevent DNA damage, inhibit NF-kB (an early response gene induced by Lu-ionizing radiation) generation pathway, inhibit PGE2, inhibit tyrosinase activity, prevent melanin transfer, and inhibit MITF activity. The decarboxylated carnosine removes free sugar to prevent the skin saccharification process, replaces glycosylated protein through a saccharification gyration mechanism, repairs the saccharified skin and mainly solves the problem of dark yellow skin.
According to the invention, the novel whitening composition is formed by combining the nonapeptide-1 & tetrapeptide-1, 3-o-ethyl ascorbic acid, the glutathione & grape fermentation extract, the centella asiatica extract, the diglucosylgallic acid and the decarboxylated carnosine, and the effects of resisting oxidation and saccharification, protecting DNA, inhibiting tyrosinase activity, preventing melanin transfer, reducing inflammatory factor expression and the like can be realized simultaneously, so that the way of influencing the skin problem is realized in an omnibearing way or reduced, the probability of the problems of skin such as darkness, spots, redness and tartness is reduced, the sheet property in the prior art is overcome, and the optimal whitening effect is achieved.
In a further embodiment of the present invention, the novel whitening composition further comprises an aqueous phase ingredient comprising one or more of deionized water, butylene glycol, glycerin, trehalose, sodium hyaluronate, ammonium acryloyldimethyl taurate/VP copolymer. The addition amount of the water phase component is 62.41-95.16% by mass percentage of the novel whitening composition. It is mainly used as a product with stable effects of moisturizing, thickening and the like.
In a further embodiment of the present invention, the novel whitening composition further comprises an oil phase ingredient comprising one or more of dimethicone, myristyl myristate, isononyl isononanoate, ethylhexyl palmitate, shea butter. The addition amount of the oil phase component is 7-15.5% by mass of the novel whitening composition. It is applied to the skin as an emollient or skin conditioner.
In a further embodiment of the present invention, the novel whitening composition further comprises an emulsifier comprising one or more of steareth-2, steareth-21, hydrogenated lecithin, glyceryl stearate & PEG-100 stearate. The addition amount of the emulsifier is 3.3-5.2% by mass of the novel whitening composition. The emulsion is mainly used as an interface emulsion of oil-water mixing, and has stable product quality.
In a further embodiment of the present invention, the novel whitening composition further comprises a humectant comprising one or more of glycerin, butylene glycol, 1, 3-propanediol, betaine, dipropylene glycol, glyceryl polyether-26, erythritol, methyl propylene glycol, hydroxyethyl urea, sodium polyglutamate, panthenol, levan, trehalose.
In a further embodiment of the present invention, the novel whitening composition further comprises a ph adjusting agent comprising one or more of triethanolamine, potassium hydroxide, arginine, sodium hydroxide, citric acid, sodium citrate. It is mainly used for adjusting the pH value of the product.
In a further embodiment of the present invention, the novel whitening composition further comprises a thickener comprising one or more of hydroxyethylcellulose, carbomer, xanthan gum, sodium acrylate/sodium acryloyldimethyl taurate copolymer, polyacrylate crosspolymer-6, ammonium acryloyldimethyl taurate/behenyl polyether-25 methacrylate crosspolymer, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, tamarind seed polysaccharide, carrageen powder, agarose. It is primarily used to increase the adherence of the composition to the skin.
In a further embodiment of the present invention, the novel whitening composition further comprises a preservative comprising one or more of methylparaben, propylparaben, chlorphenesin, phenoxyethanol, ethylhexylglycerin, hexamidine dihydrochloride, benzyl alcohol. It is mainly used for protecting formula structure and inhibiting microorganism propagation.
In a further embodiment of the present invention, the novel whitening composition further comprises a perfume, which is mainly used to adjust the taste of the composition, playing a pleasant role.
The invention reasonably mixes nonapeptide-1 & tetrapeptide-1, 3-o-ethyl ascorbic acid, glutathione & grape fermentation extract, centella asiatica extract, diglucosylgallic acid and decarboxylated carnosine according to a specific proportion to obtain a novel whitening composition which is applied to cosmetics. The skin whitening cream can simultaneously realize the effects of resisting oxidation and saccharification, protecting DNA, inhibiting tyrosinase activity, preventing melanin transfer, reducing inflammatory factor expression and the like, thereby blocking or reducing the probability of the problems of darkness, spots, redness, wax yellowness and the like of the skin, overcoming the one-sidedness of the prior art and further achieving the effect of novel skin whitening.
The novel whitening composition can be applied to various product forms of whitening cosmetics, and has the characteristics of simple preparation method, wide application and capability of meeting market demands.
In another aspect, the present invention also provides a method for preparing a novel whitening composition, which comprises the step of mixing the components of the novel whitening composition.
In another aspect, the present invention also provides a use of the novel whitening composition in skin care products, including aqueous type skin care products, gel type skin care products, emulsion type skin care products or cream type skin care products.
DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION
Embodiments of the present invention will be described in detail below with reference to examples 1-2, but those skilled in the art will appreciate that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products commercially available.
Example 1
The invention discloses novel whitening toner which comprises the following components in percentage by weight:
a whitening component 3.6-16%
The water phase component B is 81.91 to 95.16 percent
1.24 to 2.09 percent of C auxiliary agent component
As mentioned above, the novel whitening toner is characterized in that the whitening component comprises the following components in percentage by weight:
as mentioned above, the novel whitening toner comprises the following components in percentage by weight:
as mentioned above, the novel whitening toner comprises the following components in percentage by weight:
the preparation method of the novel whitening toner comprises the following steps:
s1: putting the water phase component B into a vacuum emulsifying pot, heating to 85-90 deg.C, maintaining the temperature for 10min, stirring and homogenizing for 5min until completely dissolved, vacuumizing, stirring, and cooling;
s2: cooling to 45 deg.C, adding the whitening component A, stirring, and cooling;
s3: cooling to 40-42 deg.C, adding adjuvant component C, and stirring;
s4: discharging, filling, packaging and spraying codes after the inspection is qualified;
s5: and warehousing after the inspection is qualified.
In conclusion, the invention has the effects of resisting oxidation, resisting saccharification, resisting inflammation, protecting DNA, inhibiting tyrosine activity, reducing melanin generation, balancing skin color and whitening skin.
Example 2
The invention discloses a novel whitening emulsion which comprises the following components in percentage by weight:
as described above, the novel whitening emulsion comprises the following components in percentage by weight:
as mentioned above, the novel whitening emulsion has the oil phase component which consists of the following components in percentage by weight:
as described above, the novel whitening emulsion has the following components in percentage by weight:
as described above, the novel whitening emulsion comprises the following components in percentage by weight:
as mentioned above, the novel whitening emulsion comprises the following components in percentage by weight:
the method for preparing the novel emulsion cosmetic comprises the following steps:
s1: heating the water phase component C in a vacuum emulsifying pot to 85-90 deg.C, maintaining the temperature for 10min, adding the oil phase component B and emulsifier D, stirring and homogenizing for 5min until completely emulsifying, maintaining the temperature at 80-85 deg.C for 10min, vacuumizing, stirring, cooling,
s11: cooling to 60 ℃, adding the E auxiliary agent component, stirring and cooling;
s12: cooling to 40-45 deg.C, adding phase A, and stirring;
s13: discharging, filling, packaging and spraying codes after the inspection is qualified;
s14: and warehousing after the inspection is qualified.
In conclusion, the invention has the effects of resisting oxidation, resisting saccharification, resisting inflammation, protecting DNA, inhibiting tyrosine activity, reducing melanin generation, balancing skin color and whitening skin.
Physical and chemical index detection
1. And testing the physical and chemical indexes of the novel whitening toner prepared by the method according to QB/T2660. The results are as follows:
a. appearance: light yellow to yellow transparent liquid.
b. pH value: 5.0-6.5.
c. And (3) investigating heat resistance stability: keeping the temperature at (40 +/-1) ℃ for 24h, and ensuring that no obvious character difference exists between the temperature after the temperature is restored to the room temperature and the temperature before the test, so that the product is qualified.
d. And (3) cold resistance stability investigation: keeping the temperature at (5 +/-1) ℃ for 24h, and ensuring that no obvious character difference exists between the product after the temperature is restored to the room temperature and the product before the test, so that the product is qualified.
2. The novel whitening emulsion prepared by the method is subjected to physicochemical indexes according to QB/T29665 (O/W). The results are as follows:
a. appearance: a pale yellow mobile emulsion.
b. pH value: 5.0-6.5.
c. And (3) investigating heat resistance stability: keeping the temperature at (40 +/-1) ℃ for 24h, and ensuring that no obvious character difference exists between the temperature after the temperature is restored to the room temperature and the temperature before the test, so that the product is qualified.
d. And (3) cold resistance stability investigation: keeping the temperature at (-8 +/-2) DEG C for 24h, and ensuring that no obvious character difference exists between the temperature after the temperature is restored to the room temperature and the temperature before the test, and the product is qualified.
Application performance detection
1. And (3) product safety test:
the skin care compositions obtained in examples and comparative examples were subjected to a human patch test according to the method described in technical specification for cosmetic safety (2015 edition).
The experimental population is as follows: the total 50 people, female 40 people and male 10 people, age 25-55, are divided into 2 groups, one group tests the novel whitening toner, and the other group tests the novel whitening emulsion, and the novel whitening lotion meets the volunteer selection standard of a subject.
The test method comprises the following steps: the selection area is not more than 50mm2A suitable patch tester with a depth of about 1mm, wherein about 0.020-0.025mL of the test substance is added into the patch tester by a closed patch test method; the plaque test device is pasted on the curved side of the forearm of a subject, the subject is removed after 24h, the skin reaction is observed after 0.5h, 24h and 48h respectively after the removal, and the result is recorded according to the skin reaction grading standard in technical Specification for cosmetic safety (2015 edition).
And (3) test results: the 50 subjects scored 0 at 3 observation time points 0.5h, 24h, 48h after removal of the patch (negative response).
2. And (3) product efficacy test:
a. pigmentation improvement test
Testing the population: the toner of the present invention and the placebo group toner were used on the inner side of both arms of 30 subjects (22-50 years) who formed sunburn (erythema) on both arms.
Irradiation dose: the irradiation dose of 1.5MED is carried out on the inner side of the right arm, and the irradiation time is 25 min.
Sample trial: the samples were tried 3 times per day after illumination.
And (3) phenomenon analysis: after the irradiation is finished for several hours, obvious erythema is generated, pigmentation occurs in 3-4 days, the skin brightness is reduced, and the pigment is gradually lightened along with the updating of the stratum corneum.
And (3) testing results: the erythema fades from the sixth day after the C-Cube erythema analysis test, the effect of using the toner or the emulsion is more obvious, and the erythema almost completely fades by the 14 th day. Skin brightness the skin brightness gradually increased with days using the cosmetic of the present invention.
The self-evaluation of 30 subjects showed 85% of the effects or better, 10% of the effects in the middle, and 5% of the effects, and the results were consistent with the results of C-Cube analysis and no adverse reactions.
Experiments prove that the traditional Chinese medicine can accelerate the extinction of erythema, reduce pigmentation, lighten melanin degree and brighten skin color.
Testing the population: the emulsion of the present invention and the placebo emulsion were used on 30 subjects (22-50 years old) both arms with inside UV irradiation to form sunburn (erythema) both arms.
Irradiation dose: the irradiation dose of 1.5MED is carried out on the inner side of the right arm, and the irradiation time is 25 min.
Sample trial: the samples were tried 3 times per day after illumination.
And (3) phenomenon analysis: after the irradiation is finished for several hours, obvious erythema is generated, pigmentation occurs in 3-4 days, the skin brightness is reduced, and the pigment is gradually lightened along with the updating of the stratum corneum.
And (3) testing results: the erythema fades from the sixth day after the C-Cube erythema analysis test, the effect of using the toner or the emulsion is more obvious, and the erythema almost completely fades by the 14 th day. Skin brightness the skin brightness gradually increased with days using the cosmetic of the present invention.
The self-evaluation of 30 subjects showed 85% of the effects or better, 10% of the effects in the middle, and 5% of the effects, and the results were consistent with the results of C-Cube analysis and no adverse reactions.
Experiments prove that the traditional Chinese medicine can accelerate the extinction of erythema, reduce pigmentation, lighten melanin degree and brighten skin color.
b. Clinical long-acting whitening test
The test population: 80 testers with average age of 25-40 years; wherein, 30 men and 50 women have healthy and undamaged skin; selecting the left face and the right face of the face of a subject as test areas; the sunscreen cream is used once in the morning and at night, and is used in combination with a conventional sunscreen product in the daytime.
And (3) testing a product: the novel whitening toner and the blank control group toner plus the conventional sunscreen cream are disclosed.
And (3) testing time: 2 months old
A detection instrument: VISA photographic record analysis
And (4) analyzing results: the test is carried out in the first week, the fourth week, the sixth week and the eighth week respectively, and the analysis results L value is average +0.3 in the first week, TIA value +0.5 in the fourth week, average +0.77 in the fourth week, TIA value +1.05 in the sixth week, average +1.0TIA value +1.45 in the sixth week, L value +1.21 in the eighth week, TIA value +1.75 in the sixth week
Self-evaluation results after eighth week test
Female 38 male 22 with obvious whitening effect
Female 12 men 8 with moderate whitening effect
Non-effective female 0 male 0
Content of obvious evaluation of effect: the skin becomes white, the skin color becomes uniform, the skin has luster, spots are lightened, the problem of flushing is solved, and the whitening effect is achieved. The patent is considered to have obvious whitening effect by 75% of subjects, and the skin quality improvement is moderately obvious by 25% of subjects. The subject indicated a willingness to continue using the product of this patent.
The test population: 80 testers with average age of 25-40 years; wherein, 30 men and 50 women have healthy and undamaged skin; selecting the left and right cheekbones of the face of a subject, the left and right cheeks at the intersection of the nose tip and the pupil, and the left and right sides at the intersection of the temple and the mouth corner as test areas; the sunscreen cream is used once in the morning and at night, and is used in combination with a conventional sunscreen product in the daytime.
And (3) testing a product: the novel whitening emulsion and the blank control group toner + the conventional sunscreen cream are provided.
And (3) testing time: 2 months old
A detection instrument: VISA photographic record analysis
And (4) analyzing results: the test is carried out in the first week, the fourth week, the sixth week and the eighth week respectively, and the analysis results L value is average +0.35 in the first week, TIA value +0.55 in the fourth week, average +0.8 in the fourth week, TIA value +1.1 in the sixth week, average +1.02TIA value +1.47 in the sixth week, L value +1.28 in the eighth week, TIA value +1.83 in the sixth week
Self-evaluation results after eighth week test
Female 42 male 23 with obvious whitening effect
Medium whitening effect for 8 women 7 men
Non-effective female 0 male 0
Content of obvious evaluation of effect: the skin becomes white, the skin color becomes uniform, the skin has luster, spots are lightened, the problem of flushing is solved, and the whitening effect is achieved. 81% of subjects think that the patent has obvious whitening effect, and 19% of subjects feel moderate and obvious improvement of skin. The subject indicated a willingness to continue using the product of this patent.
The above description is only a preferred embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications and equivalents of the present invention, which are made by the present specification and directly/indirectly applied to other related technical fields within the spirit of the present invention are included in the scope of the present invention.
The above description of the embodiments is only intended to facilitate the understanding of the method of the invention and its core idea. It should be noted that, for those skilled in the art, it is possible to make various improvements and modifications to the present invention without departing from the principle of the present invention, and those improvements and modifications also fall within the scope of the claims of the present invention.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (10)
1. A novel whitening composition, characterized in that it comprises, in mass percent:
nonapeptide-1 & tetrapeptide-1: 1 to 5 percent;
3-o-ethyl ascorbic acid: 0.5-3%;
glutathione & grape fermentation extract: 0.5-1%;
centella asiatica extract: 1 to 2 percent;
diglucosylgallic acid: 0.5-3%;
decarboxylated carnosine: 0.1 to 2 percent.
2. The novel whitening composition according to claim 1, further comprising an aqueous phase ingredient comprising one or more of deionized water, butylene glycol, glycerin, trehalose, sodium hyaluronate, ammonium acryloyldimethyl taurate/VP copolymer.
3. The novel whitening composition according to claim 1, further comprising an oil phase ingredient comprising one or more of dimethicone, myristyl myristate, isononyl isononanoate, ethylhexyl palmitate, shea butter.
4. The novel whitening composition of claim 1, further comprising an emulsifier comprising one or more of steareth-2, steareth-21, hydrogenated lecithin, glyceryl stearate & PEG-100 stearate.
5. The novel whitening composition according to claim 1, further comprising a humectant comprising one or more of glycerin, butylene glycol, 1, 3-propanediol, betaine, dipropylene glycol, glyceryl polyether-26, erythritol, methyl propanediol, hydroxyethyl urea, sodium polyglutamate, panthenol, levan, trehalose.
6. The novel whitening composition of claim 1, further comprising a ph modifier comprising one or more of triethanolamine, potassium hydroxide, arginine, sodium hydroxide, citric acid, sodium citrate.
7. The novel whitening composition according to claim 1, further comprising a thickener comprising one or more of hydroxyethylcellulose, carbomer, xanthan gum, sodium acrylate/sodium acryloyldimethyl taurate copolymer, polyacrylate crosspolymer-6, ammonium acryloyldimethyl taurate/behenyl polyether-25 methacrylate crosspolymer, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, tamarind seed polysaccharide, rugose carrageenan, agarose.
8. The novel whitening composition according to claim 1, further comprising a preservative comprising one or more of methylparaben, propylparaben, chlorphenesin, phenoxyethanol, ethylhexylglycerin, hexamidine dihydrochloride, benzyl alcohol.
9. A method of preparing a novel whitening composition according to any one of claims 1 to 8, comprising the step of mixing the components of the novel whitening composition.
10. Use of a novel whitening composition according to any one of claims 1 to 8 in skin care products, including aqueous, gel, emulsion or cream type skin care products.
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| CN202011554979.9A CN112618431A (en) | 2020-12-24 | 2020-12-24 | Novel whitening composition, preparation method and application |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113980098A (en) * | 2021-12-27 | 2022-01-28 | 浙江湃肽生物有限公司深圳分公司 | Nonapeptide-1 derivative and synthesis method and application thereof |
| CN117797040A (en) * | 2023-12-29 | 2024-04-02 | 济宁环聚医药科技有限公司 | Whitening nanoemulsion containing 4-butylresorcinol and preparation method thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106265236A (en) * | 2016-08-15 | 2017-01-04 | 广州澳希亚实业有限公司 | A kind of lightening compositions and the skin care item containing said composition |
| CN108524321A (en) * | 2018-05-24 | 2018-09-14 | 广州銮滢化妆品有限公司 | A kind of reduction cutaneous pigmentation topical composition and preparation method thereof |
| CN109010116A (en) * | 2018-10-23 | 2018-12-18 | 深圳市吉爱丝迪生物科技有限公司 | A kind of whitening spot-eliminating composition and its preparation method and application |
| CN109893463A (en) * | 2019-04-24 | 2019-06-18 | 深圳市健翔生物制药有限公司 | A kind of whitening peptide composition and its preparation and use |
| CN111658585A (en) * | 2020-06-24 | 2020-09-15 | 珠海美逸生物科技有限公司 | Whitening and spot-fading composition and preparation method thereof |
| CN111743796A (en) * | 2020-05-26 | 2020-10-09 | 泉后(广州)生物科技研究院有限公司 | Whitening milk and preparation method thereof |
| CN111973500A (en) * | 2019-05-24 | 2020-11-24 | 西安博鸿生物技术有限公司 | Whitening and freckle-removing essence and preparation method thereof |
-
2020
- 2020-12-24 CN CN202011554979.9A patent/CN112618431A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106265236A (en) * | 2016-08-15 | 2017-01-04 | 广州澳希亚实业有限公司 | A kind of lightening compositions and the skin care item containing said composition |
| CN108524321A (en) * | 2018-05-24 | 2018-09-14 | 广州銮滢化妆品有限公司 | A kind of reduction cutaneous pigmentation topical composition and preparation method thereof |
| CN109010116A (en) * | 2018-10-23 | 2018-12-18 | 深圳市吉爱丝迪生物科技有限公司 | A kind of whitening spot-eliminating composition and its preparation method and application |
| CN109893463A (en) * | 2019-04-24 | 2019-06-18 | 深圳市健翔生物制药有限公司 | A kind of whitening peptide composition and its preparation and use |
| CN111973500A (en) * | 2019-05-24 | 2020-11-24 | 西安博鸿生物技术有限公司 | Whitening and freckle-removing essence and preparation method thereof |
| CN111743796A (en) * | 2020-05-26 | 2020-10-09 | 泉后(广州)生物科技研究院有限公司 | Whitening milk and preparation method thereof |
| CN111658585A (en) * | 2020-06-24 | 2020-09-15 | 珠海美逸生物科技有限公司 | Whitening and spot-fading composition and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 佚名: "红酒亮白面膜", 《HTTPS://WWW.XIAOHONGSHU.COM/DISCOVERY/ITEM/5C01EE8C672E14069CA08BCF》 * |
| 汝新美肌: "【美白】真的是小姐姐们不朽的课题", 《HTTPS://ZHUANLAN.ZHIHU.COM/P/273225077》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113980098A (en) * | 2021-12-27 | 2022-01-28 | 浙江湃肽生物有限公司深圳分公司 | Nonapeptide-1 derivative and synthesis method and application thereof |
| CN117797040A (en) * | 2023-12-29 | 2024-04-02 | 济宁环聚医药科技有限公司 | Whitening nanoemulsion containing 4-butylresorcinol and preparation method thereof |
| CN117797040B (en) * | 2023-12-29 | 2024-06-04 | 济宁环聚医药科技有限公司 | Whitening nanoemulsion containing 4-butylresorcinol and preparation method thereof |
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Application publication date: 20210409 |