CN108524321A - A kind of reduction cutaneous pigmentation topical composition and preparation method thereof - Google Patents
A kind of reduction cutaneous pigmentation topical composition and preparation method thereof Download PDFInfo
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- CN108524321A CN108524321A CN201810510727.2A CN201810510727A CN108524321A CN 108524321 A CN108524321 A CN 108524321A CN 201810510727 A CN201810510727 A CN 201810510727A CN 108524321 A CN108524321 A CN 108524321A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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Abstract
The invention discloses a kind of reduction cutaneous pigmentation topical compositions and preparation method thereof, formula includes water, 1,2 pentanediols, two bay amide Gln Sodium lysinates, 3 O ethylascorbyls ethers, lauric alcohol-caprylate/decylate, Symwhite-337, nonapeptide 1, tetrapeptide 1 and arginine；Preparation method includes the following steps：Step 1, selection；Step 2, pretreatment；Step 3, it is primary to stir；Step 4, secondary agitation；Step 5, triple mixing；Step 6, Symwhite-337 processing；Step 7, mixing and filtering；Step 8, disinfection storage；The present invention advantageously reduces cutaneous pigmentation, not will produce stimulate the reaction, safe to use；Be conducive to that raw material is made fully to dissolve mixing, be stirred by the sequence that raw material adds successively, avoid multigroup raw material while stirring, causes to stir non-uniform thing generation.
Description
Technical field
The present invention relates to nursing materials technical field, specially a kind of reduction cutaneous pigmentation topical composition and its system
Preparation Method.
Background technology
The variation of hormone in vivo can cause melanin to deposit in skin, and lead to cutaneous pigmentation (such as Ai Disheng
Disease, gestation or oral contraceptive).Cutaneous pigmentation also can be caused by iron and silver deposit in skin histology, such as in blood
Pigmentation disease and argyrism.(several years) can cause ochronosus, solar radiation that can also promote skin once in a while using quinhydrones for a long time
Skin pigmentation.
In order to solve the problems, such as cutaneous pigmentation, the drug solved is assisted just to come into being.But existing skin-color
Plain topical composition has the following defects：It is mostly made using chemical substance, is unfavorable for reducing cutaneous pigmentation, will produce simultaneously
Stimulate the reaction, safety in utilization are low；It is unfavorable for that raw material is made fully to dissolve mixing when preparation, is all multigroup raw material while stirring, lead
It causes raw material stirring uneven, product using effect is made to tell somebody what one's real intentions are；For this defect, so we design a kind of reduction skin pigment
Calm topical composition and preparation method thereof is necessary.
Invention content
The purpose of the present invention is to provide a kind of reduction cutaneous pigmentation topical compositions and preparation method thereof, to solve
The problems mentioned above in the background art.
To achieve the above object, the present invention provides the following technical solutions：
A kind of reduction cutaneous pigmentation topical composition, including water, 1,2 pentanediols, two bay amide Glns rely
Propylhomoserin sodium, 3-O- ethylascorbyls ether, lauric alcohol-caprylate/decylate, Symwhite-337, nonapeptide -1, tetrapeptide -1
And arginine, said components proportioning, water are 88~95%, 1,2 pentanediols are 1~2%, two bay amide Gln lysines
Sodium is 0.1~0.5%, 3-O- ethylascorbyl ethers are 2~4%, lauric alcohol-caprylate/decylate is 1~5%, benzene second
Base resorcinol is 0.1~1%, nonapeptide -1 is 0.1~0.15%, tetrapeptide -1 is 0.1~0.15% and arginine be 0.03~
0.05%.
A kind of reduction cutaneous pigmentation topical composition preparation method, includes the following steps：Step 1, selection；Step
Two, pretreatment；Step 3, it is primary to stir；Step 4, secondary agitation；Step 5, triple mixing；Step 6, phenethyl isophthalic two
Phenol processing；Step 7, mixing and filtering；Step 8, disinfection storage；
Wherein in above-mentioned step one, by water, 1,2 pentanediols, two bay amide Gln Sodium lysinates, 3-O- second
Base ascorbic acid ether, lauric alcohol-caprylate/decylate, Symwhite-337, nonapeptide -1, tetrapeptide -1 and arginine are according to water
For 88~95%, 1,2 pentanediols be 1~2%, two bay amide Gln Sodium lysinates be 0.1~0.5%, 3-O- ethyls
Ascorbic acid ether is 2~4%, lauric alcohol-caprylate/decylate is 1~5%, Symwhite-337 is 0.1~1%, nine
Peptide -1 is that 0.1~0.15%, ratio that tetrapeptide -1 is 0.1~0.15% and arginine is 0.03~0.05% is prepared, material
Material list is solely stored；
Wherein in above-mentioned step two, the first agitated kettle and the second agitated kettle are cleaned, cleaning solution is poured out, by
Remaining moisture is wiped in one agitated kettle and the second agitated kettle, then blows hot wind by the first agitated kettle and by hair-dryer
Two agitated kettles are dried；
Wherein in above-mentioned step three, by prepared water, 1,2 pentanediols, 3-O- ethylascorbyls ether and smart ammonia
Acid pours into the first agitated kettle simultaneously, is poured slowly into, and starts the first agitated kettle, mixing speed 30r/min, and whipping temp is less than
30 DEG C, after stirring a period of time, the first agitated kettle is closed, stands a period of time；
Wherein in above-mentioned step four, by the nonapeptide -1 configured and tetrapeptide -1 while putting into the first agitated kettle, delay
Slowly it pours into, starts the first agitated kettle, mixing speed 30r/min, whipping temp is less than 30 DEG C, observes nonapeptide -1 and tetrapeptide -1 is complete
After fully dissolved, the first agitated kettle is closed；
Wherein in above-mentioned step five, prepared two bays amide Gln Sodium lysinate is put into first and is stirred
Pot is mixed, the first agitated kettle is started, after stirring is completely dissolved to two bay amide Gln Sodium lysinates, closes the first stirring
Pot stands 20min；
Wherein in above-mentioned step six, the lauric alcohol-caprylate/decylate and Symwhite-337 that will configure
It pours into the second agitated kettle, is poured slowly into simultaneously, start the second agitated kettle, mixing speed 30r/min waits for phenethyl isophthalic two
After phenol is completely dissolved, the second agitated kettle is closed, the material after stirring is poured out, deposits in clean the first container；
Wherein in above-mentioned step seven, the mixture in the first container is poured into the first agitated kettle, starts first and stirs
Pot, mixing speed 1000r/min are mixed, temperature is less than 40 DEG C, and 3~5min of reverse agitating function is enabled again after stirring 10~15min, stirs
After uniformly, the first agitated kettle is closed, then take clean second container, filter screen is placed at the top of second container, by first
Mixture export in agitated kettle, by filter screen filtration, enters in second container；
Wherein in above-mentioned step eight, will be placed in second container with disinfection cabinet, carry out disinfection sterilizing, after disinfection,
Mixture in second container is quantitatively poured into packaging bag, packaging is sealed.
According to above-mentioned technical proposal, in the step 3, mixing time is 10~15min, time of repose 10min.
According to above-mentioned technical proposal, in the step 4, mixing time 30min, observes nonapeptide -1 and tetrapeptide -1 is molten
Solution situation can extend mixing time.
According to above-mentioned technical proposal, in the step 5, mixing speed 30r/min, whipping temp is less than 30 DEG C, stirs
It is 20~25min to mix the time.
According to above-mentioned technical proposal, in the step 6, whipping temp is constant at 40 DEG C.
According to above-mentioned technical proposal, in the step 7, after filtering, filter screen is removed, is cleaned, re-disinfection is dried
It is dry.
According to above-mentioned technical proposal, in the step 8, disinfection way takes ultraviolet light or high temperature to carry out disinfection sterilizing.
Compared with prior art, the beneficial effects of the invention are as follows：
1. it be 1~2%, two bay amide Gln Sodium lysinates is 0.1 that take water, which be 88~95%, 1,2 pentanediols,
~0.5%, 3-O- ethylascorbyls ether is 2~4%, lauric alcohol-caprylate/decylate is 1~5%, phenethyl isophthalic two
Phenol is 0.1~1%, nonapeptide -1 is 0.1~0.15%, tetrapeptide -1 is 0.1~0.15% and arginine is 0.03~0.05%
Ratio is prepared, and cutaneous pigmentation is advantageously reduced, and not will produce stimulate the reaction, safe to use；
2. pass through step 3, it is primary to stir；Step 4, secondary agitation；Step 5, triple mixing；Step 6, between phenethyl
The processing of benzenediol processing and step 7, mixing and filtering, is conducive to that raw material is made fully to dissolve mixing, is added successively by raw material
Sequence be stirred, avoid multigroup raw material while stirring, lead to stir non-uniform thing and occur.
Description of the drawings
Fig. 1 is the preparation method flow chart of the present invention.
Specific implementation mode
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation describes, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
Referring to Fig. 1, the present invention provides a kind of technical solution：A kind of reduction cutaneous pigmentation topical composition and its system
Preparation Method：
Embodiment 1：
A kind of reduction cutaneous pigmentation topical composition, including water, 1,2 pentanediols, two bay amide Glns rely
Propylhomoserin sodium, 3-O- ethylascorbyls ether, lauric alcohol-caprylate/decylate, Symwhite-337, nonapeptide -1, tetrapeptide -1
And arginine, said components proportioning, water 93%, 1,2 pentanediols are that 1%, two bay amide Gln Sodium lysinates are
0.27%, 3-O- ethylascorbyls ether is 2.5%, lauric alcohol-caprylate/decylate is 2.9%, Symwhite-337
For 0.1%, nonapeptide -1 be 0.1%, tetrapeptide -1 is 0.1% and arginine is 0.03%.
A kind of reduction cutaneous pigmentation topical composition preparation method, includes the following steps：Step 1, selection；Step
Two, pretreatment；Step 3, it is primary to stir；Step 4, secondary agitation；Step 5, triple mixing；Step 6, phenethyl isophthalic two
Phenol processing；Step 7, mixing and filtering；Step 8, disinfection storage；
Wherein in above-mentioned step one, by water, 1,2 pentanediols, two bay amide Gln Sodium lysinates, 3-O- second
Base ascorbic acid ether, lauric alcohol-caprylate/decylate, Symwhite-337, nonapeptide -1, tetrapeptide -1 and arginine are according to water
For 93%, 1,2 pentanediols be 1%, two bay amide Gln Sodium lysinates be 0.27%, 3-O- ethylascorbyl ethers are
2.5%, lauric alcohol-caprylate/decylate is 2.9%, Symwhite-337 0.1%, nonapeptide -1 are 0.1%, tetrapeptide -1
For 0.1% and arginine be 0.03% ratio prepared, material is individually stored；
Wherein in above-mentioned step two, the first agitated kettle and the second agitated kettle are cleaned, cleaning solution is poured out, by
Remaining moisture is wiped in one agitated kettle and the second agitated kettle, then blows hot wind by the first agitated kettle and by hair-dryer
Two agitated kettles are dried；
Wherein in above-mentioned step three, by prepared water, 1,2 pentanediols, 3-O- ethylascorbyls ether and smart ammonia
Acid pours into the first agitated kettle simultaneously, is poured slowly into, and starts the first agitated kettle, mixing speed 30r/min, and whipping temp is less than
30 DEG C, after stirring a period of time, the first agitated kettle is closed, stands a period of time；
Wherein in above-mentioned step four, by the nonapeptide -1 configured and tetrapeptide -1 while putting into the first agitated kettle, delay
Slowly it pours into, starts the first agitated kettle, mixing speed 30r/min, whipping temp is less than 30 DEG C, observes nonapeptide -1 and tetrapeptide -1 is complete
After fully dissolved, the first agitated kettle is closed；
Wherein in above-mentioned step five, prepared two bays amide Gln Sodium lysinate is put into first and is stirred
Pot is mixed, the first agitated kettle is started, after stirring is completely dissolved to two bay amide Gln Sodium lysinates, closes the first stirring
Pot stands 20min；
Wherein in above-mentioned step six, the lauric alcohol-caprylate/decylate and Symwhite-337 that will configure
It pours into the second agitated kettle, is poured slowly into simultaneously, start the second agitated kettle, mixing speed 30r/min waits for phenethyl isophthalic two
After phenol is completely dissolved, the second agitated kettle is closed, the material after stirring is poured out, deposits in clean the first container；
Wherein in above-mentioned step seven, the mixture in the first container is poured into the first agitated kettle, starts first and stirs
Pot, mixing speed 1000r/min are mixed, temperature is less than 40 DEG C, and 3~5min of reverse agitating function is enabled again after stirring 10~15min, stirs
After uniformly, the first agitated kettle is closed, then take clean second container, filter screen is placed at the top of second container, by first
Mixture export in agitated kettle, by filter screen filtration, enters in second container；
Wherein in above-mentioned step eight, will be placed in second container with disinfection cabinet, carry out disinfection sterilizing, after disinfection,
Mixture in second container is quantitatively poured into packaging bag, packaging is sealed.
Wherein, in step 3, mixing time is 10~15min, and time of repose 10min is conducive to stir；In step
In four, mixing time 30min, observes nonapeptide -1 and tetrapeptide -1 dissolves situation, can extend mixing time, make nonapeptide -1 and four
Peptide -1 fully dissolves；In step 5, mixing speed 30r/min, whipping temp be less than 30 DEG C, mixing time be 20~
25min, convenient for stirring and dissolving；In step 6, whipping temp is constant at 40 DEG C, improves stirring and dissolving efficiency；In step 7
In, after filtering, filter screen is removed, is cleaned, re-disinfection drying is conducive to cleaning treatment, is used convenient for next time；In step
In eight, disinfection way takes ultraviolet light or high temperature to carry out disinfection sterilizing, is conducive to efficient exterminating bacterium.
Embodiment 2：
A kind of reduction cutaneous pigmentation topical composition, including water, 1,2 pentanediols, two bay amide Glns rely
Propylhomoserin sodium, 3-O- ethylascorbyls ether, lauric alcohol-caprylate/decylate, Symwhite-337, nonapeptide -1, tetrapeptide -1
And arginine, said components proportioning, water 92%, 1,2 pentanediols are that 1.5%, two bay amide Gln Sodium lysinates are
0.35%, 3-O- ethylascorbyls ether is 2.8%, lauric alcohol-caprylate/decylate is 2.8%, Symwhite-337
For 0.3%, nonapeptide -1 be 0.12%, tetrapeptide -1 is 0.1% and arginine is 0.03%.
A kind of reduction cutaneous pigmentation topical composition preparation method, includes the following steps：Step 1, selection；Step
Two, pretreatment；Step 3, it is primary to stir；Step 4, secondary agitation；Step 5, triple mixing；Step 6, phenethyl isophthalic two
Phenol processing；Step 7, mixing and filtering；Step 8, disinfection storage；
Wherein in above-mentioned step one, by water, 1,2 pentanediols, two bay amide Gln Sodium lysinates, 3-O- second
Base ascorbic acid ether, lauric alcohol-caprylate/decylate, Symwhite-337, nonapeptide -1, tetrapeptide -1 and arginine are according to water
For 92%, 1,2 pentanediols be 1.5%, two bay amide Gln Sodium lysinates be 0.35%, 3-O- ethylascorbyl ethers
For 2.8%, lauric alcohol-caprylate/decylate be 2.8%, Symwhite-337 0.3%, nonapeptide -1 are 0.12%, four
The ratio that peptide -1 is 0.1% and arginine is 0.03% is prepared, and material is individually stored；
Wherein in above-mentioned step two, the first agitated kettle and the second agitated kettle are cleaned, cleaning solution is poured out, by
Remaining moisture is wiped in one agitated kettle and the second agitated kettle, then blows hot wind by the first agitated kettle and by hair-dryer
Two agitated kettles are dried；
Wherein in above-mentioned step three, by prepared water, 1,2 pentanediols, 3-O- ethylascorbyls ether and smart ammonia
Acid pours into the first agitated kettle simultaneously, is poured slowly into, and starts the first agitated kettle, mixing speed 30r/min, and whipping temp is less than
30 DEG C, after stirring a period of time, the first agitated kettle is closed, stands a period of time；
Wherein in above-mentioned step four, by the nonapeptide -1 configured and tetrapeptide -1 while putting into the first agitated kettle, delay
Slowly it pours into, starts the first agitated kettle, mixing speed 30r/min, whipping temp is less than 30 DEG C, observes nonapeptide -1 and tetrapeptide -1 is complete
After fully dissolved, the first agitated kettle is closed；
Wherein in above-mentioned step five, prepared two bays amide Gln Sodium lysinate is put into first and is stirred
Pot is mixed, the first agitated kettle is started, after stirring is completely dissolved to two bay amide Gln Sodium lysinates, closes the first stirring
Pot stands 20min；
Wherein in above-mentioned step six, the lauric alcohol-caprylate/decylate and Symwhite-337 that will configure
It pours into the second agitated kettle, is poured slowly into simultaneously, start the second agitated kettle, mixing speed 30r/min waits for phenethyl isophthalic two
After phenol is completely dissolved, the second agitated kettle is closed, the material after stirring is poured out, deposits in clean the first container；
Wherein in above-mentioned step seven, the mixture in the first container is poured into the first agitated kettle, starts first and stirs
Pot, mixing speed 1000r/min are mixed, temperature is less than 40 DEG C, and 3~5min of reverse agitating function is enabled again after stirring 10~15min, stirs
After uniformly, the first agitated kettle is closed, then take clean second container, filter screen is placed at the top of second container, by first
Mixture export in agitated kettle, by filter screen filtration, enters in second container；
Wherein in above-mentioned step eight, will be placed in second container with disinfection cabinet, carry out disinfection sterilizing, after disinfection,
Mixture in second container is quantitatively poured into packaging bag, packaging is sealed.
Wherein, in step 3, mixing time is 10~15min, and time of repose 10min is conducive to stir；In step
In four, mixing time 30min, observes nonapeptide -1 and tetrapeptide -1 dissolves situation, can extend mixing time, make nonapeptide -1 and four
Peptide -1 fully dissolves；In step 5, mixing speed 30r/min, whipping temp be less than 30 DEG C, mixing time be 20~
25min, convenient for stirring and dissolving；In step 6, whipping temp is constant at 40 DEG C, improves stirring and dissolving efficiency；In step 7
In, after filtering, filter screen is removed, is cleaned, re-disinfection drying is conducive to cleaning treatment, is used convenient for next time；In step
In eight, disinfection way takes ultraviolet light or high temperature to carry out disinfection sterilizing, is conducive to efficient exterminating bacterium.
Embodiment 3：
A kind of reduction cutaneous pigmentation topical composition, including water, 1,2 pentanediols, two bay amide Glns rely
Propylhomoserin sodium, 3-O- ethylascorbyls ether, lauric alcohol-caprylate/decylate, Symwhite-337, nonapeptide -1, tetrapeptide -1
And arginine, said components proportioning, water 89.95%, 1,2 pentanediols are 1.8%, two bay amide Gln Sodium lysinates
For 0.45%, 3-O- ethylascorbyl ethers be 3.5%, lauric alcohol-caprylate/decylate is 3.5%, phenethyl isophthalic two
Phenol is 0.5%, nonapeptide -1 is 0.13%, tetrapeptide -1 is 0.13% and arginine is 0.04%.
A kind of reduction cutaneous pigmentation topical composition preparation method, includes the following steps：Step 1, selection；Step
Two, pretreatment；Step 3, it is primary to stir；Step 4, secondary agitation；Step 5, triple mixing；Step 6, phenethyl isophthalic two
Phenol processing；Step 7, mixing and filtering；Step 8, disinfection storage；
Wherein in above-mentioned step one, by water, 1,2 pentanediols, two bay amide Gln Sodium lysinates, 3-O- second
Base ascorbic acid ether, lauric alcohol-caprylate/decylate, Symwhite-337, nonapeptide -1, tetrapeptide -1 and arginine are according to water
For 89.95%, 1,2 pentanediols be 1.8%, two bay amide Gln Sodium lysinates be 0.45%, 3-O- ethyl Vitamin Cs
Sour ether is 3.5%, lauric alcohol-caprylate/decylate is 3.5%, Symwhite-337 0.5%, nonapeptide -1 are
0.13%, the ratio that tetrapeptide -1 is 0.13% and arginine is 0.04% is prepared, and material is individually stored；
Wherein in above-mentioned step two, the first agitated kettle and the second agitated kettle are cleaned, cleaning solution is poured out, by
Remaining moisture is wiped in one agitated kettle and the second agitated kettle, then blows hot wind by the first agitated kettle and by hair-dryer
Two agitated kettles are dried；
Wherein in above-mentioned step three, by prepared water, 1,2 pentanediols, 3-O- ethylascorbyls ether and smart ammonia
Acid pours into the first agitated kettle simultaneously, is poured slowly into, and starts the first agitated kettle, mixing speed 30r/min, and whipping temp is less than
30 DEG C, after stirring a period of time, the first agitated kettle is closed, stands a period of time；
Wherein in above-mentioned step four, by the nonapeptide -1 configured and tetrapeptide -1 while putting into the first agitated kettle, delay
Slowly it pours into, starts the first agitated kettle, mixing speed 30r/min, whipping temp is less than 30 DEG C, observes nonapeptide -1 and tetrapeptide -1 is complete
After fully dissolved, the first agitated kettle is closed；
Wherein in above-mentioned step five, prepared two bays amide Gln Sodium lysinate is put into first and is stirred
Pot is mixed, the first agitated kettle is started, after stirring is completely dissolved to two bay amide Gln Sodium lysinates, closes the first stirring
Pot stands 20min；
Wherein in above-mentioned step six, the lauric alcohol-caprylate/decylate and Symwhite-337 that will configure
It pours into the second agitated kettle, is poured slowly into simultaneously, start the second agitated kettle, mixing speed 30r/min waits for phenethyl isophthalic two
After phenol is completely dissolved, the second agitated kettle is closed, the material after stirring is poured out, deposits in clean the first container；
Wherein in above-mentioned step seven, the mixture in the first container is poured into the first agitated kettle, starts first and stirs
Pot, mixing speed 1000r/min are mixed, temperature is less than 40 DEG C, and 3~5min of reverse agitating function is enabled again after stirring 10~15min, stirs
After uniformly, the first agitated kettle is closed, then take clean second container, filter screen is placed at the top of second container, by first
Mixture export in agitated kettle, by filter screen filtration, enters in second container；
Wherein in above-mentioned step eight, will be placed in second container with disinfection cabinet, carry out disinfection sterilizing, after disinfection,
Mixture in second container is quantitatively poured into packaging bag, packaging is sealed.
Wherein, in step 3, mixing time is 10~15min, and time of repose 10min is conducive to stir；In step
In four, mixing time 30min, observes nonapeptide -1 and tetrapeptide -1 dissolves situation, can extend mixing time, make nonapeptide -1 and four
Peptide -1 fully dissolves；In step 5, mixing speed 30r/min, whipping temp be less than 30 DEG C, mixing time be 20~
25min, convenient for stirring and dissolving；In step 6, whipping temp is constant at 40 DEG C, improves stirring and dissolving efficiency；In step 7
In, after filtering, filter screen is removed, is cleaned, re-disinfection drying is conducive to cleaning treatment, is used convenient for next time；In step
In eight, disinfection way takes ultraviolet light or high temperature to carry out disinfection sterilizing, is conducive to efficient exterminating bacterium.
Embodiment 4：
A kind of reduction cutaneous pigmentation topical composition, including water, 1,2 pentanediols, two bay amide Glns rely
Propylhomoserin sodium, 3-O- ethylascorbyls ether, lauric alcohol-caprylate/decylate, Symwhite-337, nonapeptide -1, tetrapeptide -1
And arginine, said components proportioning, water 88%, 1,2 pentanediols are that 2%, two bay amide Gln Sodium lysinates are
0.5%, 3-O- ethylascorbyls ether is 3.2%, lauric alcohol-caprylate/decylate is 5%, Symwhite-337 is
1%, nonapeptide -1 is 0.1%, tetrapeptide -1 is 0.15% and arginine is 0.05%.
A kind of reduction cutaneous pigmentation topical composition preparation method, includes the following steps：Step 1, selection；Step
Two, pretreatment；Step 3, it is primary to stir；Step 4, secondary agitation；Step 5, triple mixing；Step 6, phenethyl isophthalic two
Phenol processing；Step 7, mixing and filtering；Step 8, disinfection storage；
Wherein in above-mentioned step one, by water, 1,2 pentanediols, two bay amide Gln Sodium lysinates, 3-O- second
Base ascorbic acid ether, lauric alcohol-caprylate/decylate, Symwhite-337, nonapeptide -1, tetrapeptide -1 and arginine are according to water
For 88%, 1,2 pentanediols be 2%, two bay amide Gln Sodium lysinates be 0.5%, 3-O- ethylascorbyl ethers are
3.2%, lauric alcohol-caprylate/decylate is 5%, Symwhite-337 1%, nonapeptide -1 are 0.1%, tetrapeptide -1 is
0.15% and arginine be 0.05% ratio prepared, material is individually stored；
Wherein in above-mentioned step two, the first agitated kettle and the second agitated kettle are cleaned, cleaning solution is poured out, by
Remaining moisture is wiped in one agitated kettle and the second agitated kettle, then blows hot wind by the first agitated kettle and by hair-dryer
Two agitated kettles are dried；
Wherein in above-mentioned step three, by prepared water, 1,2 pentanediols, 3-O- ethylascorbyls ether and smart ammonia
Acid pours into the first agitated kettle simultaneously, is poured slowly into, and starts the first agitated kettle, mixing speed 30r/min, and whipping temp is less than
30 DEG C, after stirring a period of time, the first agitated kettle is closed, stands a period of time；
Wherein in above-mentioned step four, by the nonapeptide -1 configured and tetrapeptide -1 while putting into the first agitated kettle, delay
Slowly it pours into, starts the first agitated kettle, mixing speed 30r/min, whipping temp is less than 30 DEG C, observes nonapeptide -1 and tetrapeptide -1 is complete
After fully dissolved, the first agitated kettle is closed；
Wherein in above-mentioned step five, prepared two bays amide Gln Sodium lysinate is put into first and is stirred
Pot is mixed, the first agitated kettle is started, after stirring is completely dissolved to two bay amide Gln Sodium lysinates, closes the first stirring
Pot stands 20min；
Wherein in above-mentioned step six, the lauric alcohol-caprylate/decylate and Symwhite-337 that will configure
It pours into the second agitated kettle, is poured slowly into simultaneously, start the second agitated kettle, mixing speed 30r/min waits for phenethyl isophthalic two
After phenol is completely dissolved, the second agitated kettle is closed, the material after stirring is poured out, deposits in clean the first container；
Wherein in above-mentioned step seven, the mixture in the first container is poured into the first agitated kettle, starts first and stirs
Pot, mixing speed 1000r/min are mixed, temperature is less than 40 DEG C, and 3~5min of reverse agitating function is enabled again after stirring 10~15min, stirs
After uniformly, the first agitated kettle is closed, then take clean second container, filter screen is placed at the top of second container, by first
Mixture export in agitated kettle, by filter screen filtration, enters in second container；
Wherein in above-mentioned step eight, will be placed in second container with disinfection cabinet, carry out disinfection sterilizing, after disinfection,
Mixture in second container is quantitatively poured into packaging bag, packaging is sealed.
Wherein, in step 3, mixing time is 10~15min, and time of repose 10min is conducive to stir；In step
In four, mixing time 30min, observes nonapeptide -1 and tetrapeptide -1 dissolves situation, can extend mixing time, make nonapeptide -1 and four
Peptide -1 fully dissolves；In step 5, mixing speed 30r/min, whipping temp be less than 30 DEG C, mixing time be 20~
25min, convenient for stirring and dissolving；In step 6, whipping temp is constant at 40 DEG C, improves stirring and dissolving efficiency；In step 7
In, after filtering, filter screen is removed, is cleaned, re-disinfection drying is conducive to cleaning treatment, is used convenient for next time；In step
In eight, disinfection way takes ultraviolet light or high temperature to carry out disinfection sterilizing, is conducive to efficient exterminating bacterium.
Based on above-mentioned, it is an advantage of the current invention that it is 88~95%, 1 that the present invention, which takes water, 2 pentanediols are 1~2%, two
Lauramide glutamine Sodium lysinate is 0.1~0.5%, 3-O- ethylascorbyl ethers are 2~4%, lauric alcohol-octanoic acid
Ester/decylate is 1~5%, Symwhite-337 is 0.1~1%, nonapeptide -1 is 0.1~0.15%, tetrapeptide -1 be 0.1~
0.15% and arginine be 0.03~0.05% ratio prepared, advantageously reduce cutaneous pigmentation, not will produce thorn
Swash reaction, it is safe to use；First agitated kettle and the second agitated kettle are cleaned, cleaning solution is poured out, by the first agitated kettle
It is wiped with remaining moisture in the second agitated kettle, then hot wind is blowed by the first agitated kettle and the second agitated kettle by hair-dryer
It is dried, by prepared water, 1,2 pentanediols, 3-O- ethylascorbyls ether and arginine pour into the first agitated kettle simultaneously
In, it being poured slowly into, starts the first agitated kettle, mixing speed 30r/min, whipping temp is less than 30 DEG C, after stirring a period of time,
The first agitated kettle is closed, a period of time is stood, by the nonapeptide -1 configured and tetrapeptide -1 while being put into the first agitated kettle, slowly
It pours into, starts the first agitated kettle, mixing speed 30r/min, whipping temp is less than 30 DEG C, observes nonapeptide -1 and tetrapeptide -1 is complete
After dissolving, the first agitated kettle is closed, prepared two bays amide Gln Sodium lysinate is put into the first agitated kettle, is opened
Dynamic first agitated kettle after stirring is completely dissolved to two bay amide Gln Sodium lysinates, is closed the first agitated kettle, is stood
20min by the lauric alcohol-caprylate/decylate and Symwhite-337 that have configured while being poured into the second agitated kettle, is delayed
Slowly it pours into, starts the second agitated kettle, mixing speed 30r/min closes second and stir after Symwhite-337 is completely dissolved
Pot is mixed, the material after stirring is poured out, deposits in clean the first container, the mixture in the first container is poured into the first stirring
In pot, start the first agitated kettle, mixing speed 1000r/min, temperature is less than 40 DEG C, is enabled again reversely after stirring 10~15min
3~5min is stirred, after stirring evenly, closes the first agitated kettle, then take clean second container, is placed at the top of second container
There is filter screen, the mixture in the first agitated kettle is exported, by filter screen filtration, enters in second container, is conducive to make
Raw material fully dissolves mixing, is stirred by the sequence that raw material adds successively, avoids multigroup raw material while stirring, causes to stir
Non-uniform thing occurs.
It should be noted that herein, relational terms such as first and second and the like are used merely to a reality
Body or operation are distinguished with another entity or operation, are deposited without necessarily requiring or implying between these entities or operation
In any actual relationship or order or sequence.Moreover, the terms "include", "comprise" or its any other variant are intended to
Non-exclusive inclusion, so that the process, method, article or equipment including a series of elements is not only wanted including those
Element, but also include other elements that are not explicitly listed, or further include for this process, method, article or equipment
Intrinsic element.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
Understanding without departing from the principles and spirit of the present invention can carry out these embodiments a variety of variations, modification, replace
And modification, the scope of the present invention is defined by the appended.
Claims (8)
1. a kind of reduction cutaneous pigmentation topical composition, including water, 1,2 pentanediols, two bay amide Glns rely ammonia
Sour sodium, 3-O- ethylascorbyls ether, lauric alcohol-caprylate/decylate, Symwhite-337, nonapeptide -1, tetrapeptide -1 and
Arginine, it is characterised in that：Said components match, and water is 88~95%, 1, and 2 pentanediols are 1~2%, two lauramide paddy ammonia
Amide Sodium lysinate is 0.1~0.5%, 3-O- ethylascorbyl ethers are 2~4%, lauric alcohol-caprylate/decylate is 1
~5%, Symwhite-337 is 0.1~1%, nonapeptide -1 is 0.1~0.15%, tetrapeptide -1 is 0.1~0.15% and smart ammonia
Acid is 0.03~0.05%.
2. a kind of reduction cutaneous pigmentation topical composition preparation method, includes the following steps：Step 1, selection；Step 2,
Pretreatment；Step 3, it is primary to stir；Step 4, secondary agitation；Step 5, triple mixing；Step 6, Symwhite-337
Processing；Step 7, mixing and filtering；Step 8, disinfection storage；It is characterized in that：
Wherein in above-mentioned step one, by water, 1,2 pentanediols, two bay amide Gln Sodium lysinates, 3-O- ethyls are anti-
Bad hematic acid ether, lauric alcohol-caprylate/decylate, Symwhite-337, nonapeptide -1, tetrapeptide -1 and arginine are 88 according to water
~95%, 1,2 pentanediols be 1~2%, two bay amide Gln Sodium lysinates be 0.1~0.5%, 3-O- ethyls it is anti-bad
Hematic acid ether is 2~4%, lauric alcohol-caprylate/decylate is 1~5%, Symwhite-337 is 0.1~1%, nonapeptide -1
The ratio that for 0.1~0.15%, tetrapeptide -1 be 0.1~0.15% and arginine is 0.03~0.05% is prepared, bill of materials
Solely stored；
Wherein in above-mentioned step two, the first agitated kettle and the second agitated kettle are cleaned, cleaning solution is poured out, first is stirred
It mixes remaining moisture in pot and the second agitated kettle to be wiped, then hot wind is blowed by hair-dryer and stirs the first agitated kettle and second
Pot is mixed to be dried；
Wherein in above-mentioned step three, by prepared water, 1,2 pentanediols, 3-O- ethylascorbyls ether and arginine are same
When pour into the first agitated kettle, be poured slowly into, start the first agitated kettle, mixing speed 30r/min, whipping temp be less than 30
DEG C, after stirring a period of time, the first agitated kettle is closed, stands a period of time；
Wherein in above-mentioned step four, by the nonapeptide -1 configured and tetrapeptide -1 while putting into the first agitated kettle, slowly fall
Enter, start the first agitated kettle, mixing speed 30r/min, whipping temp is less than 30 DEG C, observes nonapeptide -1 and tetrapeptide -1 is completely molten
Xie Hou closes the first agitated kettle；
Wherein in above-mentioned step five, prepared two bays amide Gln Sodium lysinate is put into the first stirring
Pot starts the first agitated kettle, after stirring is completely dissolved to two bay amide Gln Sodium lysinates, closes the first agitated kettle,
Stand 20min；
Wherein in above-mentioned step six, simultaneously by the lauric alcohol-caprylate/decylate and Symwhite-337 that have configured
It pours into the second agitated kettle, is poured slowly into, start the second agitated kettle, mixing speed 30r/min waits for that Symwhite-337 is complete
After fully dissolved, the second agitated kettle is closed, the material after stirring is poured out, deposits in clean the first container；
Wherein in above-mentioned step seven, the mixture in the first container is poured into the first agitated kettle, starts the first agitated kettle,
Mixing speed is 1000r/min, and temperature is less than 40 DEG C, enables 3~5min of reverse agitating function again after stirring 10~15min, stirs evenly
Afterwards, the first agitated kettle is closed, then takes clean second container, filter screen is placed at the top of second container, by the first stirring
Mixture export in pot, by filter screen filtration, enters in second container；
It wherein in above-mentioned step eight, will be placed in second container with disinfection cabinet, carry out disinfection sterilizing, after disinfection, by the
Mixture in two containers quantitatively pours into packaging bag, is sealed packaging.
3. a kind of reduction cutaneous pigmentation topical composition preparation method according to claim 2, it is characterised in that：Described
In step 3, mixing time is 10~15min, time of repose 10min.
4. a kind of reduction cutaneous pigmentation topical composition preparation method according to claim 2, it is characterised in that：Described
In step 4, mixing time 30min, observes nonapeptide -1 and tetrapeptide -1 dissolves situation, can extend mixing time.
5. a kind of reduction cutaneous pigmentation topical composition preparation method according to claim 2, it is characterised in that：Described
In step 5, mixing speed 30r/min, whipping temp is less than 30 DEG C, and mixing time is 20~25min.
6. a kind of reduction cutaneous pigmentation topical composition preparation method according to claim 2, it is characterised in that：Described
In step 6, whipping temp is constant at 40 DEG C.
7. a kind of reduction cutaneous pigmentation topical composition preparation method according to claim 2, it is characterised in that：Described
In step 7, after filtering, filter screen is removed, is cleaned, re-disinfection drying.
8. a kind of reduction cutaneous pigmentation topical composition preparation method according to claim 2, it is characterised in that：Described
In step 8, disinfection way takes ultraviolet light or high temperature to carry out disinfection sterilizing.
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