CN106109261A - Whitening and skin-brightening emulsion and preparation method thereof - Google Patents
Whitening and skin-brightening emulsion and preparation method thereof Download PDFInfo
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- CN106109261A CN106109261A CN201610571604.0A CN201610571604A CN106109261A CN 106109261 A CN106109261 A CN 106109261A CN 201610571604 A CN201610571604 A CN 201610571604A CN 106109261 A CN106109261 A CN 106109261A
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- breast
- whitening
- skin
- skin lightening
- biologically active
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- 230000002087 whitening effect Effects 0.000 title claims abstract description 81
- 239000000839 emulsion Substances 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 238000005282 brightening Methods 0.000 title abstract 3
- 238000004945 emulsification Methods 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 61
- 229920001184 polypeptide Polymers 0.000 claims abstract description 57
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 57
- 239000000341 volatile oil Substances 0.000 claims abstract description 45
- 239000003755 preservative agent Substances 0.000 claims abstract description 31
- 230000002335 preservative effect Effects 0.000 claims abstract description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 22
- 238000003756 stirring Methods 0.000 claims abstract description 13
- 206010040829 Skin discolouration Diseases 0.000 claims description 57
- 241000196324 Embryophyta Species 0.000 claims description 46
- 210000000481 breast Anatomy 0.000 claims description 35
- 239000000758 substrate Substances 0.000 claims description 29
- 239000003795 chemical substances by application Substances 0.000 claims description 22
- 239000003921 oil Substances 0.000 claims description 21
- 235000019198 oils Nutrition 0.000 claims description 21
- 230000003750 conditioning effect Effects 0.000 claims description 19
- 150000002148 esters Chemical class 0.000 claims description 13
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims description 12
- PQUXFUBNSYCQAL-UHFFFAOYSA-N 1-(2,3-difluorophenyl)ethanone Chemical compound CC(=O)C1=CC=CC(F)=C1F PQUXFUBNSYCQAL-UHFFFAOYSA-N 0.000 claims description 12
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical group OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 12
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 11
- 229960003237 betaine Drugs 0.000 claims description 11
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims description 11
- 229960003180 glutathione Drugs 0.000 claims description 11
- 235000003969 glutathione Nutrition 0.000 claims description 11
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 11
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- 240000002319 Citrus sinensis Species 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
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- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 9
- 108010020346 Polyglutamic Acid Proteins 0.000 claims description 7
- 229920002643 polyglutamic acid Polymers 0.000 claims description 7
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 6
- 238000010792 warming Methods 0.000 claims description 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 2
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- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical class [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 229910052740 iodine Inorganic materials 0.000 claims description 2
- 239000011630 iodine Substances 0.000 claims description 2
- KRPAJLYSLFNDOA-UHFFFAOYSA-N mephenesin carbamate Chemical compound CC1=CC=CC=C1OCC(O)COC(N)=O KRPAJLYSLFNDOA-UHFFFAOYSA-N 0.000 claims description 2
- 229950006838 mephenesin carbamate Drugs 0.000 claims description 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical class OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 2
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- 244000173166 Pyrus ussuriensis Species 0.000 claims 1
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- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 125000002632 imidazolidinyl group Chemical group 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
- 230000000975 bioactive effect Effects 0.000 abstract 2
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- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 11
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- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 6
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- BVTHRGZMQHOCOL-UHFFFAOYSA-N OCC(O)(C1(NC(=O)NCNC(=O)NC2(CO)NC(=O)NC2=O)NC(=O)NC1=O)CO Chemical compound OCC(O)(C1(NC(=O)NCNC(=O)NC2(CO)NC(=O)NC2=O)NC(=O)NC1=O)CO BVTHRGZMQHOCOL-UHFFFAOYSA-N 0.000 description 3
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- 230000037394 skin elasticity Effects 0.000 description 3
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
- 208000037259 Amyloid Plaque Diseases 0.000 description 2
- VQPABOFQLUBEIQ-UHFFFAOYSA-N C(C)O.[O].C1=CC=CC=C1 Chemical compound C(C)O.[O].C1=CC=CC=C1 VQPABOFQLUBEIQ-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 2
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
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- 230000036541 health Effects 0.000 description 1
- 230000008821 health effect Effects 0.000 description 1
- 230000036074 healthy skin Effects 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
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- 230000037380 skin damage Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 238000001256 steam distillation Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention provides a whitening and skin-brightening emulsion which comprises the following components in percentage by mass: 10-30% of matrix, 5-20% of skin conditioner, 0.005-5% of bioactive polypeptide, 0.1-5% of plant essential oil, 0.1-1% of preservative and the balance of water. The invention also provides a preparation method of the whitening and skin-brightening emulsion, which comprises the following steps: adding water, matrix and skin conditioner into a stirring pot, heating to 80-100 deg.C while stirring, and dissolving to obtain a first emulsion system; cooling the first emulsion system to below 45 ℃, adding the vegetable essential oil, uniformly stirring and homogenizing for 20-40 minutes to obtain a second emulsion system; and sequentially adding the bioactive polypeptide and the preservative into the second emulsion system, and fully and uniformly stirring to obtain the product.
Description
Technical field
The present invention relates to cosmetic field, especially, relate to a kind of whitening skin lightening breast and preparation method thereof.
Background technology
Along with the raising of modern life level, people increasingly focus on external image, with fine image in various work
Dynamic self-confident with increase under occasion, simultaneously under fine appearance, more pursue skin health, with healthy skin and fine shape
As representing people's pursuit to high-end life.Therefore, whitening class cosmetics are always what people were pursued, and its market share is very
Greatly.
Currently, to the idea of skin-whitening, people there occurs that essence changes, and whitening class cosmetics are from the covering of physical property
Whitening (such as muffin, foundation cream and liquid face powder etc.) is peeled off to physical property and chemical, more normal to interference and blocking-up melanin
Metabolism, develops into " cooperative effect " whitening.But above-mentioned whitening approach brings skin damage in various degree to consumer,
Make skin aging accelerate, even destroy the original defense function of skin, make skin more sensitive and vulnerable.Therefore, open
Send out natural, harmless, green physiological whitening class cosmetics, make skin health whitening, while skin whitening strengthen skin
Elasticity and toughness, make skin the most pale penetrating, will be 21 century beauty treatment science a key areas.
Biologically active polypeptide, such as tetrapeptide-1, nonapeptide-1, glutathion etc., has skin-whitening, skin lightening spot-removal function, energy
Enough suppress the activity of the tryrosinase played a crucial role in cutaneous pigmentation, block melanin and transmit to horny layer, reach
The effect of whitening skin lightening speckle dispelling, it is also possible to the formation of prevention lipofuscin senile plaque with increase the weight of, thus reach to alleviate skin aging,
Reduce pigmentation, improve the effects such as skin brightness (whitening), and due to its mechanism activity clear, superpower and body substance
Homology, high safety and the particular advantages such as be easily absorbed by the skin, it is shown that it is in physiological whitening class cosmetics side
The great potential in face and market prospect.
Plants essential oil be extraction the distinctive aromatic substance of plant, be taken from herbal flower, leaf, root, bark, fruit,
Seed, resin etc. refine the volatile flavor of extraction with distillation, squeezing, merceration or solvent extraction method etc., have natural guarantor
Being good for effect, medical treatment and its cosmetic values, it can promote the skin absorption to biologically active polypeptide, plays whitening skin lightening effect, and
And plants essential oil is natural plant essential oils, respiratory system can be entered, by breath stimulation olfactory nerves to brain centres, with god
The mode of being adjusted accelerates circulation in blood, lymph, and energy relieving psychological pressure, promotes and uses impression.
Summary of the invention
It is an object of the invention to provide a kind of natural, harmless, green physiological whitening skin lightening breast and preparation method thereof,
Its by biologically active polypeptide and have the quintessence oil of white-skinned face function with the use of, stimulate healthy new cell regeneration, affect skin histology
Cellular metabolism, reaches skin whitening, dispels the effect of speckle, makes that skin is fair and clear, water is tender, smooth and high resilience, presents health
Young skin state.
Technical scheme is as follows:
A kind of whitening skin lightening breast, includes following component by mass percentage: substrate 10-30%, skin conditioning agent 5-
20%, biologically active polypeptide 0.005-5%, plants essential oil 0.1-5%, preservative 0.1-1%, surplus is water.
The biologically active polypeptide in described whitening skin lightening Ruzhong is safe and nontoxic and the highest small molecular protein of activity, can press down
Make the activity of the tryrosinase played a crucial role in cutaneous pigmentation, block melanin and transmit to horny layer, reach whitening
The effect of skin lightening speckle dispelling, it is also possible to the formation of prevention lipofuscin senile plaque with increase the weight of, thus reach to alleviate skin aging, minimizing
Pigmentation, improve the effects such as skin brightness (whitening).Compared with the collagen protein that molecular weight is bigger, enzyme etc., biological activity is many
Peptide has that the mechanism of action is clear, have superpower activity and body substance homology, easily the advantage such as be absorbed by the skin.
The plants essential oil component in described whitening skin lightening Ruzhong is from the flower of plant, leaf, stem, root or fruit, is steamed by water
Steam distillation method, milling process, cold-maceration or solvent extraction method refine the volatile flavor of extraction, have natural health effect,
Medical treatment and its cosmetic values, it can promote the skin absorption to biologically active polypeptide, play whitening skin lightening effect, and plant is smart
Oil is natural plant essential oils, can enter respiratory system, by breath stimulation olfactory nerves to brain centres, with neuroregulation side
Formula accelerates circulation in blood, lymph, and energy relieving psychological pressure, promotes and uses impression.
Preferably, described whitening skin lightening breast includes following component by mass percentage: substrate 10-15%, skin condition
Agent 10-20%, biologically active polypeptide 0.005-5%, plants essential oil 1-3%, preservative 0.1-1%, surplus is water.
Preferably, described biologically active polypeptide is the mixture of one or more of tetrapeptide-1, nonapeptide-1 and glutathion.
Preferably, described plants essential oil is Fructus Citri Limoniae quintessence oil, Flos Rosae Rugosae quintessence oil, sweet orange oil, grapefruit essential oil and Fructus Citri Sarcodactylis essence
The mixture of one or more of oil.
Preferably, described substrate is one or more of carbomer, sorbitan stearate, triethanolamine and sodium acrylate
Mixture.
Preferably, described skin conditioning agent is Jojoba wax PEG-120 esters, propylene glycol, glycine betaine, beta glucan, thoroughly
Bright matter acid sodium, polyglutamic acid and the mixture of one or more of polyquaternary ammonium salt-51.
Preferably, described preservative be Bis(hydroxymethyl)imidazolidinyl urea, iodine propilolic alcohol butyl mephenesin Carbamate, propylene glycol,
The mixture of one or more of phenoxyethanol and Sensiva SC50.
The preparation method of whitening skin lightening breast described above, comprises the following steps:
Water, substrate and skin conditioning agent being added in agitated kettle, warming while stirring is to 80-100 DEG C so that it is the most molten
Solve, obtain the first emulsion system；
First emulsion system being cooled to less than 45 DEG C, adds plants essential oil, stir also homogenizing 20-40 minute,
To the second emulsion system；
In the second emulsion system, it is sequentially added into biologically active polypeptide and preservative, stirs, obtain product.
Before product fill, packing, put in storage, needing to detect the performance such as viscosity and surface tension, it is qualified to detect
Afterwards can fill, pack, put in storage.
Preferably, during described biologically active polypeptide joins the second emulsion system as an aqueous solution.
Biologically active polypeptide is added directly into breast by the preparation method of the whitening skin lightening breast of the present invention as an aqueous solution
In liquid system, by emulsifying agent parcel and the effect of dispersant, biologically active polypeptide is made to be dispersed in emulsion, biological activity
Peptide is quickly absorbed by skin, plays whitening skin lightening effect；And plants essential oil directly joins emulsion system with the form of doping
In so that it is it is evenly distributed, gives full play to stimulate neural, to beautify skin effect；Simultaneously as the effect of people's body-internal-circulation also has
It is beneficial to the skin absorption to biologically active polypeptide material.
Compared to prior art, it is an advantage of the current invention that: the whitening skin lightening breast of the present invention is by biologically active polypeptide and merit
Energy property plants essential oil compound use, on the one hand, there is the biologically active polypeptide of whitening skin lightening effect as active ingredient, play
Its superpower activity and body substance homology, high safety and the particular advantages such as be easily absorbed by the skin, on the other hand,
Coordinate the compounding of functional plants quintessence oil, formation biologically active polypeptide and functional plants quintessence oil, promote that whitening effect skin lightening becomes
The absorption divided, whitening skin lightening effect of multi-faceted raising product, the most effectively play plants essential oil and biologically active polypeptide to people
The synergism of body, reaches whitening skin lightening effect；Additionally, the preparation method of the present invention, there is the advantages such as simple, easy operation.
Detailed description of the invention
In order to be better understood from, implement the claim of the present invention, below in conjunction with specific embodiment, the right to the present invention
Requirement is described in further detail, it is clear that described embodiment is only a part of embodiment rather than all of the present invention
Embodiment.Based on the embodiment in the present invention, those of ordinary skill in the art are institute under not making creative work premise
The all other embodiments obtained, broadly fall into the scope of protection of the invention.
Embodiment 1
A kind of whitening skin lightening breast that the present invention provides, includes following component: substrate 12.65%, skin by mass percentage
Conditioner 13.12%, biologically active polypeptide 0.009%, plants essential oil 2%, preservative 0.5%, surplus is water.
Wherein:
Described substrate is made up of the component of following mass percent: carbomer: 11%, sorbitan stearate: 0.8%,
Triethanolamine: 0.25%, sodium acrylate: 0.6%；
Described skin conditioning agent is made up of the component of following mass percent: Jojoba wax PEG-120 esters: 1%, the third two
Alcohol: 3%, glycine betaine: 3%, beta glucan: 5%, hyaluronate sodium: 0.07%, polyglutamic acid: 0.05%, polyquaternium-51:
1%；
Described biologically active polypeptide is made up of the component of following mass percent: tetrapeptide-1:0.002%, nonapeptide-1:
0.001%, glutathion: 0.006%；
Described plants essential oil is made up of the component of following mass percent: Flos Rosae Rugosae quintessence oil: 1%, sweet orange oil: 1%；
Described preservative is made up of the component of following mass percent: phenoxyethanol: 0.3%, Sensiva SC50:
0.2%.
Embodiment 2
The another kind of whitening skin lightening breast that the present invention provides, includes following component: substrate 11.45%, skin by mass percentage
Skin conditioner 15.36%, biologically active polypeptide 0.1%, plants essential oil 2%, preservative 0.5%, surplus is water.
Wherein:
Described substrate is made up of the component of following mass percent: carbomer: 9%, sorbitan stearate: 0.6%, three
Ethanolamine: 1.25%, sodium acrylate: 0.6%；
Described skin conditioning agent is made up of the component of following mass percent: Jojoba wax PEG-120 esters: 1%, the third two
Alcohol: 4%, glycine betaine: 3%, beta glucan: 6%, hyaluronate sodium: 0.28%, polyglutamic acid: 0.08%, polyquaternium-51:
1%；
Described biologically active polypeptide is made up of the component of following mass percent: tetrapeptide-1:0.005%, nonapeptide-1:
0.059%, glutathion: 0.036%；
Described plants essential oil is made up of the component of following mass percent: Fructus Citri Limoniae quintessence oil: 1%, Flos Rosae Rugosae quintessence oil: 1%；
Described preservative is made up of the component of following mass percent: phenoxyethanol: 0.3%, Sensiva SC50:
0.2%.
Embodiment 3
The another kind of whitening skin lightening breast that the present invention provides, includes following component: substrate 14.38%, skin by mass percentage
Skin conditioner 18.16%, biologically active polypeptide 0.8%, plants essential oil 2%, preservative 0.7%, surplus is water.
Wherein:
Described substrate is made up of the component of following mass percent: carbomer: 8%, sorbitan stearate: 2.36%,
Sodium acrylate: 4.02%；
Described skin conditioning agent is made up of the component of following mass percent: Jojoba wax PEG-120 esters: 2%, the third two
Alcohol: 4%, glycine betaine: 5%, beta glucan: 5%, hyaluronate sodium: 0.16%, polyquaternium-51:2%；
Described biologically active polypeptide is made up of the component of following mass percent: tetrapeptide-1:0.25%, nonapeptide-1:
0.40%, glutathion: 0.15%；
Described plants essential oil is made up of the component of following mass percent: Flos Rosae Rugosae quintessence oil: 1%, sweet orange oil: 1%；
Described preservative is made up of the component of following mass percent: phenoxyethanol: 0.3%, Sensiva SC50:
0.4%.
Embodiment 4
The another kind of whitening skin lightening breast that the present invention provides, includes following component: substrate 20%, skin are adjusted by mass percentage
Reason agent 15.75%, biologically active polypeptide 2%, plants essential oil 2.5%, preservative 0.8%, surplus is water.
Wherein:
Described substrate is made up of the component of following mass percent: carbomer: 15%, sorbitan stearate: 2.1%,
Triethanolamine: 1.85%, sodium acrylate: 1.05%；
Described skin conditioning agent is made up of the component of following mass percent: Jojoba wax PEG-120 esters: 0.6%, third
Glycol: 3%, glycine betaine: 3%, beta glucan: 6%, polyglutamic acid: 0.15%, polyquaternium-51:3%；
Described biologically active polypeptide is made up of the component of following mass percent: tetrapeptide-1:1.13%, nonapeptide-1:
0.59%, glutathion: 0.28%；
Described plants essential oil is made up of the component of following mass percent: Flos Rosae Rugosae quintessence oil: 1%, sweet orange oil: 1%, Fructus Citri Sarcodactylis
Citrus chachiensis Hort. quintessence oil 0.5%；
Described preservative is made up of the component of following mass percent: Bis(hydroxymethyl)imidazolidinyl urea: 0.3%, benzene oxygen
Ethanol: 0.3%, Sensiva SC50: 0.2%.
Embodiment 5
The another kind of whitening skin lightening breast that the present invention provides, includes following component: substrate 22.36%, skin by mass percentage
Skin conditioner 17.38%, biologically active polypeptide 3%, plants essential oil 1.5%, preservative 0.4%, surplus is water.
Wherein:
Described substrate is made up of the component of following mass percent: carbomer: 10%, sorbitan stearate: 3.8%,
Triethanolamine: 6.45%, sodium acrylate: 2.11%；
Described skin conditioning agent is made up of the component of following mass percent: Jojoba wax PEG-120 esters: 3%, the third two
Alcohol: 3%, glycine betaine: 3%, beta glucan: 6%, polyglutamic acid: 0.38%, polyquaternium-51:2%；
Described biologically active polypeptide is made up of the component of following mass percent: tetrapeptide-1:1%, nonapeptide-1:1%, paddy Guang
Sweet peptide: 1%；
Described plants essential oil is made up of the component of following mass percent: Flos Rosae Rugosae quintessence oil: 0.5%, sweet orange oil: 1%；
Described preservative is made up of the component of following mass percent: phenoxyethanol: 0.2%, Sensiva SC50:
0.2%.
Embodiment 6
The another kind of whitening skin lightening breast that the present invention provides, includes following component: substrate 21.87%, skin by mass percentage
Skin conditioner 15.44%, biologically active polypeptide 4.5%, plants essential oil 3%, preservative 0.8%, surplus is water.
Wherein:
Described substrate is made up of the component of following mass percent: carbomer: 14%, sorbitan stearate: 3.7%,
Triethanolamine: 2.28%, sodium acrylate: 1.89%；
Described skin conditioning agent is made up of the component of following mass percent: Jojoba wax PEG-120 esters: 1%, the third two
Alcohol: 4%, beta glucan: 8%, hyaluronate sodium: 0.19%, polyglutamic acid: 0.25%, polyquaternium-51:2%；
Described biologically active polypeptide is made up of the component of following mass percent: tetrapeptide-1:1.5%, nonapeptide-1:1.5%,
Glutathion: 1%；
Described plants essential oil is made up of the component of following mass percent: Flos Rosae Rugosae quintessence oil: 1%, sweet orange oil: 1%, Fructus Vitis viniferae
Shaddock oil: 1%；
Described preservative is made up of the component of following mass percent: Bis(hydroxymethyl)imidazolidinyl urea: 0.3%, benzene oxygen
Ethanol: 0.3%, Sensiva SC50: 0.2%.
The method of any one whitening skin lightening breast in preparation embodiment 1-6, comprises the following steps:
Step S1, weighs each component by any one group of mass percent in embodiment 1-6；
Step S2, adds water, substrate and skin conditioning agent in agitated kettle, and warming while stirring is to 80-100 DEG C so that it is
Fully dissolve, obtain the first emulsion system；
Step S3, is cooled to less than 45 DEG C by the first emulsion system, adds plants essential oil, stirs and homogenizing 20-40
Minute, obtain the second emulsion system；
Step S4, is sequentially added into biologically active polypeptide and preservative in the second emulsion system, stirs, obtain
Product；
Step S5, carries out the performance such as viscosity and surface tension to product and detects, detect qualified after, fill, packaging, enter
Storehouse.
Preferably, biologically active polypeptide is first dissolved in aqueous solution, then joins as an aqueous solution in reaction system, wherein
Tetrapeptide-1 is 500ppm aqueous solution, and nonapeptide-1 is 500ppm aqueous solution, and glutathion is 2000ppm aqueous solution.
The whitening skin lightening breast prepared by above-described embodiment is respectively after 10 volunteers try out 90 days continuously, with commercially available whitening
Product contrasts, and the index of evaluation is whitening skin degree, brightness and the elastic degree promoted, and is divided into 10 degree specifically
Grade, the integer of intensity grade 0-9 is indicated (wherein without, numerical value is the biggest, 0=represents that the degree promoted is the highest), specifically ties
Fruit is such as following table:
| Sample | Whitening skin degree | Brightness | Elastic |
| Embodiment 1 | 4 | 3 | 3 |
| Embodiment 2 | 6 | 5 | 4 |
| Embodiment 3 | 7 | 5 | 5 |
| Embodiment 4 | 7 | 6 | 5 |
| Embodiment 5 | 8 | 7 | 6 |
| Embodiment 6 | 8 | 6 | 7 |
| Commercially available prod 1 | 1 | 0 | 0 |
From upper table data it can be seen that use the whitening skin lightening breast of the present invention program, the whitening skin degree of volunteer is notable
Increase, skin brightness raises, speckle desalinates obvious, the elasticity of skin and toughness strengthens, and the whitening skin lightening breast tool of the present invention is described
Having good whitening skin lightening result, along with the content of biologically active polypeptide increases, whitening skin lightening result is the most obvious, and relative to
Commercially available Skin whitening care cosmetics, the whitening skin lightening result of the present invention is more notable, it is also possible to desalination speckle, strengthens skin elasticity and toughness.
In order to verify the composite whitening effect between biologically active polypeptide variety classes, the present invention also provides for implementing accordingly
Example, wherein embodiment 7 is containing two kinds of biologically active polypeptide, and content is same as in Example 3, and other component and content equal
Same as in Example 3, embodiment 8 comprises only a type of biologically active polypeptide, and content is same as in Example 3, and other group
Dividing and content is the most same as in Example 3, the preparation method of embodiment 7 and embodiment 8 is the most same as in Example 3.
Embodiment 7
The another kind of whitening skin lightening breast that the present invention provides, includes following component: substrate 14.38%, skin by mass percentage
Skin conditioner 18.16%, biologically active polypeptide 0.8%, plants essential oil 2%, preservative 0.7%, surplus is water.
Wherein:
Described substrate is made up of the component of following mass percent: carbomer: 8%, sorbitan stearate: 2.36%,
Sodium acrylate: 4.02%；
Described skin conditioning agent is made up of the component of following mass percent: Jojoba wax PEG-120 esters: 2%, the third two
Alcohol: 4%, glycine betaine: 5%, beta glucan: 5%, hyaluronate sodium: 0.16%, polyquaternium-51:2%；
Described biologically active polypeptide is made up of the component of following mass percent: tetrapeptide-1:0.45%, glutathion:
0.35%；
Described plants essential oil is made up of the component of following mass percent: Flos Rosae Rugosae quintessence oil: 1%, sweet orange oil: 1%；
Described preservative is made up of the component of following mass percent: phenoxyethanol: 0.3%, Sensiva SC50:
0.4%.
Embodiment 8
The another kind of whitening skin lightening breast that the present invention provides, includes following component: substrate 14.38%, skin by mass percentage
Skin conditioner 18.16%, biologically active polypeptide 0.8%, plants essential oil 2%, preservative 0.7%, surplus is water.
Wherein:
Described substrate is made up of the component of following mass percent: carbomer: 8%, sorbitan stearate: 2.36%,
Sodium acrylate: 4.02%；
Described skin conditioning agent is made up of the component of following mass percent: Jojoba wax PEG-120 esters: 2%, the third two
Alcohol: 4%, glycine betaine: 5%, beta glucan: 5%, hyaluronate sodium: 0.16%, polyquaternium-51:2%；
Described biologically active polypeptide is made up of the component of following mass percent: tetrapeptide-1:0.8%；
Described plants essential oil is made up of the component of following mass percent: Flos Rosae Rugosae quintessence oil: 1%, sweet orange oil: 1%；
Described preservative is made up of the component of following mass percent: phenoxyethanol: 0.3%, Sensiva SC50:
0.4%.
The whitening skin lightening breast that embodiment 3, embodiment 7 and embodiment 8 prepare is tried out 90 continuously through 10 volunteers respectively
After it, contrasting with commercially available whitening product, the index of evaluation is whitening skin degree, brightness and the elastic degree promoted, specifically
For be divided into 10 intensity grades, the integer of intensity grade 0-9 is indicated that (wherein 0=promoted without, numerical value the biggest expression
Degree is the highest), concrete outcome such as following table:
| Sample | Whitening skin degree | Brightness | Elastic |
| Embodiment 3 | 7 | 5 | 5 |
| Embodiment 7 | 6 | 4 | 3 |
| Embodiment 8 | 4 | 2 | 3 |
From upper table data it can be seen that embodiment 3 contains the whitening skin lightening effect of the biologically active polypeptide of three types simultaneously
Preferably, embodiment 7 is containing two kinds of biologically active polypeptide, and its whitening skin lightening result is placed in the middle, and embodiment 8 comprises only one for fruit
The biologically active polypeptide of type, its whitening skin lightening result is worst, and therefore, different types of biologically active polypeptide compound use is permissible
Significantly improve whitening skin lightening result.
In order to verify the synergism of biologically active polypeptide and plants essential oil, the present invention also provides for corresponding comparative example, its
Middle comparative example 1 does not contains plants essential oil, and other component and content are the most same as in Example 3, and it is many that comparative example 2 does not contains biological activity
Peptide, other component and content are the most same as in Example 3, and the preparation method of comparative example 1 and comparative example 2 is same as in Example 3.
Comparative example 1
A kind of whitening skin lightening breast, includes following component by mass percentage: substrate 14.38%, skin conditioning agent
18.16%, biologically active polypeptide 0.8%, preservative 0.7%, surplus is water.
Wherein:
Described substrate is made up of the component of following mass percent: carbomer: 8%, sorbitan stearate: 2.36%,
Sodium acrylate: 4.02%；
Described skin conditioning agent is made up of the component of following mass percent: Jojoba wax PEG-120 esters: 2%, the third two
Alcohol: 4%, glycine betaine: 5%, beta glucan: 5%, hyaluronate sodium: 0.16%, polyquaternium-51:2%；
Described biologically active polypeptide is made up of the component of following mass percent: tetrapeptide-1:0.25%, nonapeptide-1:
0.40%, glutathion: 0.15%；
Described preservative is made up of the component of following mass percent: phenoxyethanol: 0.3%, Sensiva SC50:
0.4%.
Comparative example 2
A kind of whitening skin lightening breast, includes following component by mass percentage: substrate 14.38%, skin conditioning agent
18.16%, plants essential oil 2%, preservative 0.7%, surplus is water.
Wherein:
Described substrate is made up of the component of following mass percent: carbomer: 8%, sorbitan stearate: 2.36%,
Sodium acrylate: 4.02%；
Described skin conditioning agent is made up of the component of following mass percent: Jojoba wax PEG-120 esters: 2%, the third two
Alcohol: 4%, glycine betaine: 5%, beta glucan: 5%, hyaluronate sodium: 0.16%, polyquaternium-51:2%；
Described plants essential oil is made up of the component of following mass percent: Flos Rosae Rugosae quintessence oil: 1%, sweet orange oil: 1%；
Described preservative is made up of the component of following mass percent: phenoxyethanol: 0.3%, Sensiva SC50:
0.4%.
By whitening skin lightening breast prepared to embodiment 3 and comparative example 1-2 respectively after 10 volunteers try out 90 days continuously, with
Commercially available Skin whitening care cosmetics comparing result is as follows:
In embodiment 3 and comparative example 1-2, in addition to biologically active polypeptide is different with the content of plants essential oil, other group
Dividing and content is the most identical, embodiment 3 contains the biologically active polypeptide of three types and two kinds of plants essential oil simultaneously, and it is beautiful
White skin lightening result is optimum；Biologically active polypeptide containing three types of comparative example 1 and its content are same as in Example 3, its whitening
Skin lightening result is placed in the middle；Comparative example 2 is same as in Example 3 containing two kinds of plants essential oil and its content, and its whitening skin lightening is imitated
Fruit is more weak, therefore, can embody the association of multiple biologically active polypeptide and plants essential oil from the result of the test of these three embodiment
Same-action, and relative to commercially available Skin whitening care cosmetics, the whitening skin lightening result of the present invention is more notable, it is also possible to desalination speckle, increase
Strong skin elasticity and toughness.
It should be appreciated that the application of the present invention is not limited to above-mentioned citing, for those of ordinary skills, can
To be improved according to the above description or to convert, all these modifications and variations all should belong to the guarantor of claims of the present invention
Protect scope.
Claims (9)
1. a whitening skin lightening breast, it is characterised in that include following component by mass percentage: substrate 10-30%, skin are adjusted
Reason agent 5-20%, biologically active polypeptide 0.005-5%, plants essential oil 0.1-5%, preservative 0.1-1%, surplus is water.
Whitening skin lightening the most according to claim 1 breast, it is characterised in that described whitening skin lightening breast wraps by mass percentage
Include following component: substrate 10-25%, skin conditioning agent 10-20%, biologically active polypeptide 0.005-5%, plants essential oil 1-3%,
Preservative 0.1-1%, surplus is water.
Whitening skin lightening the most according to claim 1 breast, it is characterised in that described biologically active polypeptide be tetrapeptide-1, nonapeptide-
1 and the mixture of one or more of glutathion.
Whitening skin lightening the most according to claim 1 breast, it is characterised in that described plants essential oil is Fructus Citri Limoniae quintessence oil, rhodamine toner
The mixture of one or more of oil, sweet orange oil, grapefruit essential oil and Bergamot.
Whitening skin lightening the most according to claim 1 breast, it is characterised in that described substrate is carbomer, the smooth stearic acid of Pyrusussuriensis
The mixture of one or more of ester, triethanolamine and sodium acrylate.
Whitening skin lightening the most according to claim 1 breast, it is characterised in that described skin conditioning agent is Jojoba wax PEG-
One or more of 120 esters, propylene glycol, glycine betaine, beta glucan, hyaluronate sodium, polyglutamic acid and polyquaternary ammonium salt-51
Mixture.
Whitening skin lightening the most according to claim 1 breast, it is characterised in that described preservative is double (methylol) imidazolidinyls
Urea, iodine propilolic alcohol butyl mephenesin Carbamate, phenoxyethanol and the mixture of one or more of Sensiva SC50.
8. according to the preparation method of the whitening skin lightening breast described in claim 1-7 any one, it is characterised in that include following step
Rapid:
Water, substrate and skin conditioning agent being added in agitated kettle, warming while stirring is to 80-100 DEG C so that it is fully dissolve,
To the first emulsion system；
First emulsion system is cooled to less than 45 DEG C, adds plants essential oil, stir and homogenizing 20-40 minute, obtain the
Two emulsion systems；
In the second emulsion system, it is sequentially added into biologically active polypeptide and preservative, stirs, obtain product.
The preparation method of whitening skin lightening the most according to claim 8 breast, it is characterised in that described biologically active polypeptide is with water
Solution form joins in the second emulsion system.
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| CN107982127A (en) * | 2017-12-08 | 2018-05-04 | 广州赛莱拉干细胞科技股份有限公司 | Whitening and tightening emulsion containing cell growth factors and preparation method and application thereof |
| CN108056929A (en) * | 2016-11-07 | 2018-05-22 | 珠海联邦制药股份有限公司 | A kind of peptide composition for inhibiting melanogenesis and application |
| CN108338933A (en) * | 2017-01-23 | 2018-07-31 | 珠海联邦制药股份有限公司 | A kind of peptide composition and its application for whitening and reparation skin |
| CN108524321A (en) * | 2018-05-24 | 2018-09-14 | 广州銮滢化妆品有限公司 | A kind of reduction cutaneous pigmentation topical composition and preparation method thereof |
| CN109010116A (en) * | 2018-10-23 | 2018-12-18 | 深圳市吉爱丝迪生物科技有限公司 | A kind of whitening spot-eliminating composition and its preparation method and application |
| CN110115694A (en) * | 2019-05-23 | 2019-08-13 | 中山市粤美医疗生物科技有限公司 | A kind of Essence with whitening, effect of dispelling spots |
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| CN105362088A (en) * | 2015-12-22 | 2016-03-02 | 深圳市维琪医药研发有限公司 | Polypeptide composition for skin whitening and spot relieving |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108056929A (en) * | 2016-11-07 | 2018-05-22 | 珠海联邦制药股份有限公司 | A kind of peptide composition for inhibiting melanogenesis and application |
| CN108056929B (en) * | 2016-11-07 | 2020-11-10 | 珠海联邦制药股份有限公司 | Polypeptide composition for inhibiting melanogenesis and application thereof |
| CN108338933A (en) * | 2017-01-23 | 2018-07-31 | 珠海联邦制药股份有限公司 | A kind of peptide composition and its application for whitening and reparation skin |
| CN107982127A (en) * | 2017-12-08 | 2018-05-04 | 广州赛莱拉干细胞科技股份有限公司 | Whitening and tightening emulsion containing cell growth factors and preparation method and application thereof |
| CN108524321A (en) * | 2018-05-24 | 2018-09-14 | 广州銮滢化妆品有限公司 | A kind of reduction cutaneous pigmentation topical composition and preparation method thereof |
| CN109010116A (en) * | 2018-10-23 | 2018-12-18 | 深圳市吉爱丝迪生物科技有限公司 | A kind of whitening spot-eliminating composition and its preparation method and application |
| CN110115694A (en) * | 2019-05-23 | 2019-08-13 | 中山市粤美医疗生物科技有限公司 | A kind of Essence with whitening, effect of dispelling spots |
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Application publication date: 20161116 |