CN109010116A - A kind of whitening spot-eliminating composition and its preparation method and application - Google Patents
A kind of whitening spot-eliminating composition and its preparation method and application Download PDFInfo
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- CN109010116A CN109010116A CN201811238709.XA CN201811238709A CN109010116A CN 109010116 A CN109010116 A CN 109010116A CN 201811238709 A CN201811238709 A CN 201811238709A CN 109010116 A CN109010116 A CN 109010116A
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- whitening spot
- whitening
- eliminating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to technical field of compositions, and in particular to a kind of whitening spot-eliminating composition, composition include the component of following mass percents: whitening spot-removing component 1-22%, carrier 78-99%；Wherein whitening spot-removing component is made of nonapeptide -1, tetrapeptide -1, carnosine, ascorbic acid glucoside and niacinamide, it is transmitted using nonapeptide -1 from the extracellular information for blocking melanin to be formed in access by nti-freckle combination, melanin is inhibited to generate from source, while can pigmentation after prevention of inflammation；Carnosine has powerful scavenging activated oxygen, anti-oxidant, anti-aging effects, also has superior anti-glycosylation, can protect skin collagen, yellow significant effect of dispelling.Ascorbic acid glucoside releases vitamin C by glucosidase and inhibits tyrosinase activity formation to inhibit melanin and produced melanin by reduction desalination；Niacinamide can inhibit melanin to be transferred to horn cell from melanocyte, and reach better whitening effect.
Description
Technical field
The present invention relates to technical field of compositions, and in particular to a kind of whitening spot-eliminating composition and preparation method thereof and answers
With.
Background technique
The type of the melanin that the colour of skin, hair color and the eye color of people is mainly synthesized with melanocyte, quantity and point
Cloth is related.In melanocyte, by the catalytic action of tyrosinase, tyrosine is successively oxidized to DOPA and DOPA quinone,
DOPA quinone is further converted to dopachrome；In the catalysis respectively of DHI enzyme and dopachrome interconvertible enzyme and DHICA oxidizing ferment
Under effect, dopachrome passes through 5,6- dihydroxy indole and 5, and 6- dihydroxy indole -2- carboxylic acid is further converted to 5,6- indoles
Quinone and 5,6- istain -2- carboxylic acid；5,6- istain and 5,6- istain -2- carboxylic acid, which finally polymerize, forms melanin.Tyrosine
Enzyme is the first step rate-limiting enzyme and key enzyme of B16 cell.Therefore, all contain tyrosinase inhibitor in most of whitening agents.
Melanin formed due to be it is various, to make product whitening effect significant, it is necessary to Comprehensive consider
The reason of melanin formation, the generation and transfer process of melanin are acted on using a variety of whitening raw materials multipaths, plays its association
Same whitening function.
Since the life stress of modern people is big, rhythm is fast, the irregular rule of life such as often stay up late, and by gas
The influence for waiting the factors such as environment leads to dry skin, intensely dark pool, turns to be yellow and is easy long spot.
Summary of the invention
It is an object of the invention to solve the problems, such as the skin of above-mentioned modern.
To achieve the above object, the present invention provides the following technical scheme that a kind of whitening spot-eliminating composition, the composition
Component including following mass percents: whitening spot-removing component: 1-22%, carrier: 78-99%；The wherein whitening spot-removing group
Divide and is made of nonapeptide -1, tetrapeptide -1, carnosine, ascorbic acid glucoside and niacinamide.
Further preferred embodiment of the present invention, the nonapeptide -1 account for the 1-15% of total composition.
Further preferred embodiment of the present invention, the carnosine account for the 0.1-1% of total composition.
Further preferred embodiment of the present invention, the ascorbic acid glucoside account for the 1-2% of total composition.
Further preferred embodiment of the present invention, the niacinamide account for the 1-4% of total composition.
Further preferred embodiment of the present invention, the carrier further includes moisturizer: 0.1-10%, thickener: 0.1-
0.7%, releive agent: 0.05-0.65%, preservative: 0.5-2% and remaining be deionized water.
Further preferred embodiment of the present invention, the moisturizer are selected from glycerol, butanediol, trehalose, hyaluronic acid
At least one of sodium, panthenol.
Further preferred embodiment of the present invention, the thickener are selected from hydroxyethyl cellulose, xanthan gum, acryloyl two
At least one of N-methyltaurine ammonium/VP copolymer.
Further preferred embodiment of the present invention, it is described releive agent in allantoin, dipotassium glycyrrhizinate at least one
Kind.
Further preferred embodiment of the present invention, the preservative are selected from hexylene glycol, pentanediol, decoyl hydroximic acid, sweet
At least one of oily octanoic acid rouge.
Further preferred embodiment of the present invention, the whitening spot-removing component is by nonapeptide -1, carnosine, ascorbic acid glucose
Glycosides and niacinamide composition.
It is another object of the present invention to the preparation methods for proposing above-mentioned whitening spot-eliminating composition.
The preparation method of the whitening spot-eliminating composition, includes the following steps:
1), deionized water, moisturizer, thickener are successively imported according to combinations of the above object ratio in heating container, is stirred
It mixes uniformly, is allowed to mix；
2) above-mentioned mixed liquor is heated to 80-90 DEG C, stirring and dissolving is uniform；
3) above-mentioned mixed liquor is cooled to 40-45 DEG C, sequentially add whitening spot-removing component, agent of releiving, preservative according to
Secondary addition, stirs evenly, and is cooled to room temperature.
It is another object of the present invention to propose the whitening spot-eliminating composition in preparation whitening and freckle-removing product
Using.
In conclusion the invention has the following advantages:
This kind of whitening spot-eliminating composition and its preparation method and application, by nti-freckle combination using nonapeptide -1 from extracellular
The information transmitting for blocking melanin to be formed in access, inhibits melanin to generate from source, while can pigmentation after prevention of inflammation；
Carnosine has powerful scavenging activated oxygen, anti-oxidant, anti-aging effects, also has superior anti-glycosylation, can protect
Skin collagen, yellow significant effect of dispelling.Ascorbic acid glucoside releases vitamin C by glucosidase and inhibits tyrosinase
Activity has produced melanin to inhibit the formation of melanin and by reduction desalination；Niacinamide can inhibit melanin from black
Plain cell is transferred to horn cell, to reach better whitening effect.
Specific embodiment
For a more detailed description to the present invention combined with specific embodiments below, embodiments of the present invention are not limited thereto,
Embodiment is exemplary, it is intended to is used to explain the present invention, and is not considered as limiting the invention.For not indicating especially
Technological parameter or condition, can refer to routine techniques progress.
The present invention provides a kind of whitening spot-eliminating composition, composition includes the component of following mass percents: whitening is dispelled
Spot component: 1-22%, carrier: 78-99%；Wherein whitening spot-removing component is by nonapeptide -1, tetrapeptide -1, carnosine, ascorbic acid glucose
Glycosides and niacinamide composition.
In further preferred embodiment of the present invention, nonapeptide -1 accounts for the 1-15% of total composition；Carnosine accounts for composition
The 0.1-1% of total amount；Ascorbic acid glucoside accounts for the 1-2% of total composition；Niacinamide accounts for the 1-4% of total composition；It carries
Body further includes moisturizer: 0.1-10%, thickener: 0.1-0.7%, agent of releiving: 0.05-0.65%, preservative: 0.5-2% with
And remaining is deionized water；Moisturizer is selected from at least one of glycerol, butanediol, trehalose, Sodium Hyaluronate, panthenol；Thickening
Agent is selected from least one of hydroxyethyl cellulose, xanthan gum, ammonium acryloyl taurate/VP copolymer；Agent of releiving choosing
From at least one of allantoin, dipotassium glycyrrhizinate；Preservative is selected from hexylene glycol, pentanediol, decoyl hydroximic acid, glycerol octanoic acid rouge
At least one of；Whitening spot-removing component is made of nonapeptide -1, carnosine, ascorbic acid glucoside and niacinamide.
The whitening spot-removing component of composition above-mentioned raw materials component: moisturizer: thickener: agent of releiving: preservative: deionized water
Specific gravity be 1-22:0.1-10:0.1-0.7:0.05-0.65:0.5-2:20-52.A kind of preparation side of whitening spot-eliminating composition
Method includes the following steps:
1), deionized water, moisturizer, thickener are successively imported according to combinations of the above object ratio in heating container, is stirred
It mixes uniformly, is allowed to mix；
2) above-mentioned mixed liquor is heated to 80-90 DEG C, stirring and dissolving is uniform；
3) above-mentioned mixed liquor is cooled to 40-45 DEG C, sequentially add whitening spot-removing component, agent of releiving, preservative according to
Secondary addition, stirs evenly, and is cooled to room temperature.
Test method: choosing 33-35 year old women, and after face cleaning, this composition is equably applied to face, morning and evening two
It is secondary, it uses 56 days.
The composition can be used as general composition and use, and have the beautiful effect of whitening after smearing.
It is collocated with each other in the present invention using small-molecular peptides and traditional whitening spot-removing raw material, improves skin from many aspects and approach
Skin is obscure, and the effect of whitening effect is significant.
In the present invention, this kind of whitening spot-eliminating composition and its preparation method and application utilizes nine by nti-freckle combination
Peptide -1 inhibits melanin to generate, while can prevent inflammation from the extracellular information transmitting for blocking melanin to be formed in access from source
Pigmentation after disease；Carnosine has powerful scavenging activated oxygen, anti-oxidant, anti-aging effects, also has superior anti-glycosylation
Effect, can protect skin collagen, yellow significant effect of dispelling.Ascorbic acid glucoside releases vitamin by glucosidase
C inhibits tyrosinase activity the formation to inhibit melanin and has produced melanin by reduction desalination；Niacinamide can press down
Melanin processed is transferred to horn cell from melanocyte, to reach better whitening effect.
Embodiment table one
In table one:
Freckle effect: the spot on subjects skin, at least one dark color spots, the number ratio of light spot reduction
Example.
In table one:
Whitening effect: subject's skin brightness is promoted and the number ratio of colour of skin improving uniformity.
In table one:
Skin improves satisfaction: subject is to using product, the satisfaction of skin entirety improvement.
Interpretation of result: shown in table one as above, the freckle effect and whitening effect of example 4 are preferable, and subjects skin improves full
Meaning degree is best.
Above-described embodiment is served only for that invention is further explained to specific descriptions of the invention, should not be understood as
Limiting the scope of the present invention, those skilled in the art make the present invention according to the content of foregoing invention
Nonessential modifications and adaptations are fallen within the scope of protection of the present invention.
Claims (13)
1. a kind of whitening spot-eliminating composition, which is characterized in that the composition includes the component of following mass percents: whitening is dispelled
Spot component: 1-22%, carrier: 78-99%；Wherein the whitening spot-removing component is by nonapeptide -1, tetrapeptide -1, carnosine, ascorbic acid
Glucoside and niacinamide composition.
2. a kind of whitening spot-eliminating composition according to claim 1, it is characterised in that: the nonapeptide -1 accounts for total composition
1-15%.
3. a kind of whitening spot-eliminating composition according to claim 1, it is characterised in that: the carnosine accounts for total composition
0.1-1%.
4. a kind of whitening spot-eliminating composition according to claim 1, it is characterised in that: the ascorbic acid glucoside accounts for group
Close the 1-2% of object total amount.
5. a kind of whitening spot-eliminating composition according to claim 1, it is characterised in that: the niacinamide accounts for total composition
1-4%.
6. a kind of whitening spot-eliminating composition according to claim 1, it is characterised in that: the carrier further includes moisturizer:
0.1-10%, thickener: 0.1-0.7%, agent of releiving: 0.05-0.65%, preservative: 0.5-2% and remaining be deionization
Water.
7. a kind of whitening spot-eliminating composition according to claim 6, it is characterised in that: the moisturizer is selected from glycerol, fourth
At least one of glycol, trehalose, Sodium Hyaluronate, panthenol.
8. a kind of whitening spot-eliminating composition according to claim 6, it is characterised in that: it is fine that the thickener is selected from ethoxy
Tie up at least one of element, xanthan gum, ammonium acryloyl taurate/VP copolymer.
9. a kind of whitening spot-eliminating composition according to claim 6, it is characterised in that: it is described releive agent be selected from allantoin,
At least one of dipotassium glycyrrhizinate.
10. a kind of whitening spot-eliminating composition according to claim 6, it is characterised in that: the preservative be selected from hexylene glycol,
At least one of pentanediol, decoyl hydroximic acid, glycerol octanoic acid rouge.
11. a kind of whitening spot-eliminating composition according to claim 1, it is characterised in that: the whitening spot-removing component is by nine
Peptide -1, carnosine, ascorbic acid glucoside and niacinamide composition.
12. the preparation method of -11 described in any item whitening spot-eliminating compositions according to claim 1, which is characterized in that including such as
Lower step:
1), deionized water, moisturizer, thickener are successively imported according to combinations of the above object ratio in heating container, stirring is equal
It is even, it is allowed to mix；
2) above-mentioned mixed liquor is heated to 80-90 DEG C, stirring and dissolving is uniform；
3) above-mentioned mixed liquor is cooled to 40-45 DEG C, sequentially adds whitening spot-removing component, agent of releiving, preservative successively add
Enter, stir evenly, is cooled to room temperature.
13. application of the described in any item whitening spot-eliminating compositions of claim 1-11 in preparation whitening and freckle-removing product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811238709.XA CN109010116A (en) | 2018-10-23 | 2018-10-23 | A kind of whitening spot-eliminating composition and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811238709.XA CN109010116A (en) | 2018-10-23 | 2018-10-23 | A kind of whitening spot-eliminating composition and its preparation method and application |
Publications (1)
| Publication Number | Publication Date |
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| CN109010116A true CN109010116A (en) | 2018-12-18 |
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ID=64613911
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| CN201811238709.XA Pending CN109010116A (en) | 2018-10-23 | 2018-10-23 | A kind of whitening spot-eliminating composition and its preparation method and application |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110787081A (en) * | 2019-12-12 | 2020-02-14 | 广东博然堂生物科技有限公司 | Whitening and anti-wrinkle composition and skin care product thereof |
| CN110812271A (en) * | 2019-11-16 | 2020-02-21 | 王洪波 | Polypeptide whitening and spot-fading essence and preparation method thereof |
| CN111012715A (en) * | 2020-01-10 | 2020-04-17 | 西安润玉医疗科技有限公司 | Whitening composition capable of improving chloasma and preparation method thereof |
| CN111743796A (en) * | 2020-05-26 | 2020-10-09 | 泉后(广州)生物科技研究院有限公司 | Whitening milk and preparation method thereof |
| CN111973500A (en) * | 2019-05-24 | 2020-11-24 | 西安博鸿生物技术有限公司 | Whitening and freckle-removing essence and preparation method thereof |
| CN112618431A (en) * | 2020-12-24 | 2021-04-09 | 广州尚品生物科技有限公司 | Novel whitening composition, preparation method and application |
| CN112826756A (en) * | 2021-01-15 | 2021-05-25 | 广州诺禾生物科技有限公司 | Whitening compound peptide and application thereof |
| CN113274305A (en) * | 2021-06-23 | 2021-08-20 | 植物医生(广东)生物科技有限公司 | Instant firming wrinkle-removing whitening mask liquid and preparation method and application thereof |
| CN113893184A (en) * | 2021-10-28 | 2022-01-07 | 安徽瀚海博兴生物技术有限公司 | Polypeptide whitening and freckle removing composition, skin care product and preparation method |
| CN114712260A (en) * | 2022-04-07 | 2022-07-08 | 上海新高姿化妆品有限公司 | Skin external composition with effects of relieving, repairing and whitening skin |
| CN115381727A (en) * | 2022-09-27 | 2022-11-25 | 广州森野生物医药科技有限公司 | Whitening and freckle removing composition and preparation method thereof |
| CN115708797A (en) * | 2022-11-07 | 2023-02-24 | 上海上柯医药有限公司 | Antioxidant composition and application thereof |
| CN118161440A (en) * | 2024-05-14 | 2024-06-11 | 中科微针（北京）科技有限公司 | Whitening and freckle-removing composition, gel, and preparation method and application thereof |
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Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111973500A (en) * | 2019-05-24 | 2020-11-24 | 西安博鸿生物技术有限公司 | Whitening and freckle-removing essence and preparation method thereof |
| CN110812271A (en) * | 2019-11-16 | 2020-02-21 | 王洪波 | Polypeptide whitening and spot-fading essence and preparation method thereof |
| CN110787081A (en) * | 2019-12-12 | 2020-02-14 | 广东博然堂生物科技有限公司 | Whitening and anti-wrinkle composition and skin care product thereof |
| CN111012715A (en) * | 2020-01-10 | 2020-04-17 | 西安润玉医疗科技有限公司 | Whitening composition capable of improving chloasma and preparation method thereof |
| CN111743796A (en) * | 2020-05-26 | 2020-10-09 | 泉后(广州)生物科技研究院有限公司 | Whitening milk and preparation method thereof |
| CN112618431A (en) * | 2020-12-24 | 2021-04-09 | 广州尚品生物科技有限公司 | Novel whitening composition, preparation method and application |
| CN112826756A (en) * | 2021-01-15 | 2021-05-25 | 广州诺禾生物科技有限公司 | Whitening compound peptide and application thereof |
| CN113274305B (en) * | 2021-06-23 | 2023-02-03 | 植物医生(广东)生物科技有限公司 | Instant firming, wrinkle-removing and whitening mask liquid as well as preparation method and application thereof |
| CN113274305A (en) * | 2021-06-23 | 2021-08-20 | 植物医生(广东)生物科技有限公司 | Instant firming wrinkle-removing whitening mask liquid and preparation method and application thereof |
| CN113893184A (en) * | 2021-10-28 | 2022-01-07 | 安徽瀚海博兴生物技术有限公司 | Polypeptide whitening and freckle removing composition, skin care product and preparation method |
| CN114712260A (en) * | 2022-04-07 | 2022-07-08 | 上海新高姿化妆品有限公司 | Skin external composition with effects of relieving, repairing and whitening skin |
| CN114712260B (en) * | 2022-04-07 | 2023-08-01 | 上海新高姿化妆品有限公司 | Skin external composition with soothing and whitening effects |
| CN115381727A (en) * | 2022-09-27 | 2022-11-25 | 广州森野生物医药科技有限公司 | Whitening and freckle removing composition and preparation method thereof |
| CN115381727B (en) * | 2022-09-27 | 2023-07-04 | 广州森野生物医药科技有限公司 | Whitening and freckle-removing composition and preparation method thereof |
| CN115708797A (en) * | 2022-11-07 | 2023-02-24 | 上海上柯医药有限公司 | Antioxidant composition and application thereof |
| CN118161440A (en) * | 2024-05-14 | 2024-06-11 | 中科微针（北京）科技有限公司 | Whitening and freckle-removing composition, gel, and preparation method and application thereof |
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Application publication date: 20181218 |