CN113893184A - Polypeptide whitening and freckle removing composition, skin care product and preparation method - Google Patents
Polypeptide whitening and freckle removing composition, skin care product and preparation method Download PDFInfo
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
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Abstract
The invention discloses a polypeptide whitening and freckle removing composition, a skin care product and a preparation method, and relates to the technical field of skin care products. The polypeptide whitening and freckle-removing composition comprises: polypeptide compound, acetyl tyrosine, VC ethyl ether, arbutin, tocopherol acetate, hydroxytyrosol, nicotinamide and ethylhexyl methoxycinnamate, wherein the polypeptide compound is a nonapeptide-1, glutathione, carnosine and hexapeptide-2 mixture; the polypeptide whitening and freckle-removing skin care product comprises a humectant, a polypeptide whitening and freckle-removing composition, grease, an emulsifier, a thickening agent, a preservative, a chelating agent, essence, a proper amount of a pH regulator and the balance of deionized water. According to the invention, by adding the whitening polypeptide which is easily absorbed by the skin and whitening components such as acetyl tyrosine, VC ethyl ether, arbutin, tocopherol acetate and the like, the melanin generation of melanocytes can be inhibited through multiple mechanisms, and the generated melanin in the deep layer of the skin is inhibited from transferring to the surface layer of the skin, so that the whitening effect is achieved.
Description
Technical Field
The invention belongs to the technical field of skin care products, and particularly relates to a polypeptide whitening and freckle removing composition, a skin care product and a preparation method thereof.
Background
The color of human skin depends on the content and distribution of melanin, and the structural function and quantity of melanocytes directly influence the content of melanin in skin, and are also the determining factors for melanin production.
Melanin is synthesized by melanocytes, which are divided into dendritic melanocytes and non-dendritic melanocytes, and can synthesize melanin, but only dendritic melanocytes can transport melanin to other cells, and dendritic melanocytes are mainly in human skin. The synthesis of melanin in dendritic melanocyte comprises oxidizing tyrosine into Dopaquinone (DQ) under the catalysis of Tyrosinase (TYR), and autooxidizing dopaquinone to generate DOPA (DOPA) and Dopachrome (DC); at the same time, dopa can also be directly generated by tyrosine under the catalysis of tyrosinase, and dopa can also be generated into dopaquinone again under the catalysis of tyrosinase; DOPAquinone can generate products of 5, 6-Dihydroxyindole (DHI) and 5, 6-dihydroxyindole carboxylic acid (DHICA) respectively through oxidative decarboxylation or catalysis of DOPAchrome isomerase (TYR-2), the products generate black to dark brown DHI melanin and brown DHICA melanin through a series of oxidation reactions or catalysis of enzyme, and the pigments are true melanin and are main sources of black in skin; in the presence of cysteine or glutathione, dopaquinone is converted into cysteinyl DOPA (Cys-DOPA), and finally, yellow to reddish brown PHEO melanin (pheomelanin) is generated through a series of oxidation. Melanin is produced by melanocytes in the deep layer of the skin at first and then continuously transferred to the surface skin of a human body, and the process of melanin transfer is summarized as follows: melanocytes produce melanin; the melanin granules are transferred to the keratinocytes through the melanocyte dendritic processes, and the melanin granules moving to the keratinocytes ascend to the stratum corneum along with the epidermal cells, so that the skin color is deepened or color spots are generated; most of the melanin is finally excreted in vitro as the stratum corneum is shed.
Based on the principle of skin melanin synthesis, whitening can be started from the following methods: adding a tyrosine structural analogue to inhibit the combination of tyrosinase and tyrosine; secondly, directly controlling or inhibiting the activity of various enzymes (such as tyrosinase) in the process of generating melanin; ③ the generation of melanin is blocked by reducing each intermediate in the process of generating melanin or combining with the intermediate; regulating and controlling the proliferation and melanin synthesis capacity of melanocyte in the signal path; selectively destroying melanocyte, inhibiting melanin formation and changing its structure.
On the basis of the principle that melanin is produced from the deep skin and transferred to epidermal cells, whitening can be started from the following methods: inhibiting transfer of melanin to keratinocytes; secondly, transfer of melanin in the keratinocytes to the direction of horny layer is accelerated, and simultaneously horny metabolism is enhanced, so that old keratinocytes are easy to fall off, the falling of the horny layer is accelerated, and the metabolism of melanin is accelerated; and controlling exogenous influence factors, mainly ultraviolet irradiation.
Disclosure of Invention
The invention aims to provide a polypeptide skin-care product containing the polypeptide skin-care product capable of inhibiting tyrosinase activity, inhibiting tyrosine and tyrosine kinase from combining, inhibiting oxidation generation of melanin, inhibiting melanin from transferring to a cuticle direction, and simultaneously having a sun-screening function, and inhibiting melanin generation from the source. The skin care product has stable components, mild product, and no irritation to skin.
In order to solve the technical problems, the invention is realized by the following technical scheme:
the invention relates to a polypeptide whitening and freckle-removing composition, which comprises the following components in percentage by weight: 10-30% of polypeptide compound, 5-15% of acetyl tyrosine, 5-15% of VC ethyl ether, 5-15% of arbutin, 2-10% of tocopheryl acetate, 5-15% of hydroxytyrosol, 10-20% of nicotinamide and 10-30% of ethylhexyl methoxycinnamate; still further, the composite material comprises the following components in percentage by weight: 20% of polypeptide compound, 10% of acetyl tyrosine, 10% of VC ethyl ether, 10% of arbutin, 5% of tocopherol acetate, 10% of hydroxytyrosol, 15% of nicotinamide and 20% of ethylhexyl methoxycinnamate.
Further, the polypeptide complex is a mixture of nonapeptide-1, glutathione, carnosine and hexapeptide-2, wherein the weight ratio of the nonapeptide-1 to the glutathione to the carnosine to the hexapeptide-2 is 2: 3: 3: 2.
the polypeptide whitening and freckle-removing composition is used for preparing skin care products or medical products for external use of human skin.
A polypeptide whitening and freckle-removing skin care product comprises, by weight, 10-30% of a humectant, 5-30% of a polypeptide whitening and freckle-removing composition, 10-25% of grease, 0.5-8% of an emulsifier, 0.5-5% of a thickening agent, 0.01-2% of a preservative, 0.1-0.5% of a chelating agent, 0.001-0.1% of an essence, a proper amount of a pH regulator and the balance of deionized water.
Further, the humectant is selected from one or more of glycerol, butanediol, 1, 3-propylene glycol, hexyldecanol, sorbitol and xylitol;
the oil is selected from one or more of squalane, dimethyl polysiloxane, shea butter oil, sucrose dilaurate, trimethoxyoctylsilane, and phytosterol/octyldodecanol lauroyl glutamate;
the emulsifier is one or more selected from hydrogenated lecithin, polysorbate-20, polysorbate-60, potassium cetyl phosphate, laureth-7, methyl dextran polyether-10, PEG-9 dimethyl silicone oxyethyl polydimethylsiloxane, PPG-1-PEG-9 lauryl glycol ether;
the thickening agent is selected from one or more of xanthan gum, carbomer, polyacrylate cross-linked polymer-6, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer;
the preservative is selected from one or more of phenoxyethanol, butylated hydroxytoluene, benzyl alcohol and sodium benzoate;
the pH regulator is selected from one or more of sodium hydroxide, potassium hydroxide, aminomethyl propanol, sodium citrate and triethanolamine;
the chelating agent is EDTA-2Na and/or EDTA-4 Na;
the essence is peach blossom essence.
A preparation method of a polypeptide skin-whitening and freckle-removing skin care product comprises the following steps:
step1, weighing the grease and the emulsifier according to the formula ratio, adding the grease and the emulsifier into a stirring pot, heating and stirring to completely dissolve and uniformly disperse the components to obtain a phase A;
step2, weighing deionized water and the polypeptide whitening and freckle-removing composition according to the formula ratio, adding the deionized water and the polypeptide whitening and freckle-removing composition into another stirring pot, heating and stirring to completely dissolve and uniformly disperse the components to obtain a phase B;
step3, adding the phase A into the phase B under the stirring condition, then weighing the thickening agent and the preservative according to the formula ratio, adding into a stirring pot, heating and stirring to completely dissolve and uniformly disperse the components to obtain a phase C;
step4, under the condition of stirring, weighing the pH regulator according to the formula ratio, the chelating agent and the essence into the phase C, completely dissolving and uniformly dispersing all the components, standing, entering an aseptic production line for filling after sampling and detecting, and warehousing after bacteria inspection, wherein the final product is the product.
Further, in Step1, heating and stirring at 65-75 deg.C at 80-100rpm for 10-15 min;
the temperature of the thermal stirring in the Step2 is 40-50 ℃, the stirring speed is 150-200rpm, and the stirring time is 5-8 minutes;
after the thickening agent is added into Step3, stirring at the temperature of 50-55 ℃, at the stirring speed of 50-80rpm for 3-5 minutes;
adding pH regulator, chelating agent and essence into Step4, stopping heating, stirring at 60-100rpm for 3-5 min, standing at room temperature for 3-5 hr to obtain final product with pH of 5-6.
The invention starts from the principle of synthesizing the true melanin by skin cells and the route of melanin transfer, designs the product, and is beneficial to inhibiting the generation of the true melanin in the skin from the source and inhibiting the transfer of the true melanin to the epidermis of a human body, thereby leading the skin to be white, transparent and glossy.
In order to further explain the whitening principle of the polypeptide whitening and freckle-removing composition added in the skin care product, the following description is given by combining the generation and transfer pathways of melanin:
the polypeptide compound in the polypeptide whitening and freckle removing composition is rich in four polypeptides, namely nonapeptide-1, glutathione, carnosine and hexapeptide-2, and has whitening effect. Nonapeptide-1 can compete with alpha-melanocyte stimulating hormone (alpha-MSH) for melanocortin receptor-1 (MC1-R), so that the binding rate of the alpha-MSH and MC1-R is reduced, the ability of MC1-R to activate tyrosinase is further inhibited, and the synthesis pathway of melanin in melanocytes is effectively blocked from the source. Thereby having the effects of reducing pigmentation, whitening skin, improving skin color and lightening color spots.
The glutathione is tripeptide composed of glutamic acid, cysteine and glycine, and is in two forms of oxidized glutathione and reduced glutathione existing in human body, wherein the reduced glutathione can inhibit the activity of tyrosinase, and the inhibition effect and the concentration of the reduced glutathione are in positive correlation. During the process of melanin synthesis, glutathione can provide cysteine, so that dopaquinone reacts with cysteine to generate cysteine dopa, and finally, limonin which is easy to hydrolyze and absorb is synthesized. Thereby achieving the effects of whitening, removing freckles and brightening skin.
Carnosine is a dipeptide consisting of beta-alanine and L-histidine, carnosine is a natural anti-glycation agent, intradermal collagen reacts with sugar in a maillard reaction to generate a glycosylation product, the grey yellow color changes into yellow brown color, the skin loses elasticity and turns yellow, and carnosine can react with sugar in a saccharification reaction to reduce the glycation level of protein in the skin. Thereby achieving the effects of removing yellow skin and brightening skin color.
Hexapeptide-2 has antagonistic effect on alpha-melanocyte stimulating hormone, and can reduce the binding of alpha-melanocyte stimulating hormone and melanocortin receptor-1, and reduce melanin generation. Thereby achieving the effects of reducing high-pigment spots, brightening skin and whitening skin.
The polypeptide whitening and freckle removing composition contains acetyl tyrosine, VC ethyl ether, arbutin, tocopheryl acetate, hydroxytyrosol, nicotinamide and ethylhexyl methoxycinnamate besides polypeptide compounds, and the compounds also have a certain whitening effect. Acetyl tyrosine (N-acetyl-L-tyrosine) is a structural analogue of tyrosine, which competes with tyrosine for binding to tyrosinase, while the product does not continue to react and ultimately produce melanin. Thereby having the effects of reducing melanin generation, whitening skin and improving skin color, and being an efficient and safe amino acid whitening agent.
VC ethyl ether is a VC derivative, and an ethyl ether structure is added on the basis of the original VC, so that an enol structure with unstable VC becomes stable and is hydrophilic and lipophilic. VC reduces the generation of melanin through the interaction with the active sites of tyrosinase, can also be used as a reducing agent of dopaquinone in the process of melanin synthesis, and participates in the metabolism of tyrosinase in vivo to promote the decomposition of tyrosinase. The VC ethyl ether not only has the advantages of VC, but also is very stable in structure, thereby achieving the effects of reducing melanin generation, whitening skin, resisting oxidation and clearing free radicals.
The arbutin can inhibit the biological activity of tyrosinase and the generation of melanin, and the arbutin can accelerate the decomposition and metabolism of the melanin and reduce the deposition of the melanin, thereby achieving the effects of whitening, lightening spots, repairing damage, resisting oxidation and preventing sunburn.
Tocopheryl acetate is a compound produced by esterification of tocopherol (vitamin E) and acetic acid and has antioxidant, uv damage preventing, and free radical damage preventing effects.
Hydroxytyrosol is a tyrosol olive extract, has a catechol structure, is a typical antioxidant stress substance and free radical scavenger, and has sustained antioxidant, anti-free radical and skin whitening effects.
Nicotinamide is a derivative of vitamin B3, and has effects in inhibiting the transfer of melanosomes from melanocytes to keratinocytes, reducing the transfer of melanin to epidermal cells, whitening skin, resisting oxidation, resisting saccharification, resisting inflammation, and keeping moisture.
Ethylhexyl methoxycinnamate is the most widely used ultraviolet absorbent worldwide, can effectively prevent 280-310nm ultraviolet rays, and has excellent sunscreen effect.
The invention has the following beneficial effects:
1. the invention provides a polypeptide whitening and freckle-removing composition, which contains whitening polypeptides such as nonapeptide-1, glutathione, carnosine and hexapeptide-2, wherein the small molecules of the whitening polypeptides are easy to be absorbed by skin, and whitening components such as acetyl tyrosine, VC ethyl ether, arbutin, tocopherol acetate and the like, can inhibit melanin cells from generating melanin through multiple mechanisms, and inhibit the generated melanin in the deep layer of the skin from transferring to the surface layer of the skin, so that the whitening effect is achieved, and no side effect is caused on a human body.
2. The polypeptide whitening and freckle-removing composition provided by the invention also comprises the following common ultraviolet protective agent components: the ethylhexyl methoxycinnamate has the capability of preventing ultraviolet rays from directly irradiating the skin, further has the effects of preventing keratinocytes from secreting various neuropeptides, stimulating melanocytes to transcribe and generate key enzymes for synthesizing melanin, and fundamentally inhibiting the generation of melanin in skin cells.
3. The formula of the whitening cosmetic is mild, the materials are easily available in the market, the whitening cosmetic does not contain substances harmful to skin and human bodies, such as mercury, hydroquinone and the like, contained in the traditional chemical whitening cosmetic, and the preservative also adopts compounds mild to skin, such as phenoxyethanol, benzyl alcohol and the like, so that the side effect of the whitening cosmetic to the human skin is effectively reduced. Of course, it is not necessary for any product in which the invention is practiced to achieve all of the above-described advantages at the same time.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a process flow diagram of the preparation method of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the present invention, it is to be understood that the terms "opening," "upper," "lower," "thickness," "top," "middle," "length," "inner," "peripheral," and the like are used in an orientation or positional relationship that is merely for convenience in describing and simplifying the description, and do not indicate or imply that the referenced component or element must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be considered as limiting the present invention.
Example 1
Whitening and freckle removing essence
The implementation provides a whitening and freckle-removing essence containing a polypeptide whitening and freckle-removing composition, which comprises the following components in percentage by mass:
as shown in fig. 1, the preparation method of the whitening and freckle-removing essence comprises the following steps:
the method comprises the following steps: adding the grease and the emulsifier into a stirring pot, heating and stirring for 10 minutes at 100rpm and 65 ℃ to completely dissolve and uniformly disperse all the components to be used as an A phase;
step two: adding the deionized water and the polypeptide whitening and freckle-removing composition into another stirring pot, heating and stirring for 5 minutes at 150rpm and 40 ℃ to completely dissolve and uniformly disperse the components to obtain a phase B;
step three: adding the phase A into the phase B under stirring, adding the thickening agent and the preservative into a stirring pot, heating and stirring for 5 minutes at 70rpm and 50 ℃ to completely dissolve and uniformly disperse the components to obtain a phase C;
step four: and (3) under the stirring condition of 75rpm, adding a pH regulator, a chelating agent and essence into the phase C to completely dissolve and uniformly disperse the components, standing for 4 hours, taking samples to be detected to be qualified, filling the samples in an aseptic production line, and warehousing the samples after being detected to be qualified through bacteria, wherein the final product is the product.
Example 2: whitening and freckle removing emulsion
The implementation provides a whitening and freckle-removing emulsion containing a polypeptide whitening and freckle-removing composition, which comprises the following components in percentage by mass:
as shown in fig. 1, the preparation method of the whitening and freckle-removing emulsion comprises the following steps:
the method comprises the following steps: adding the grease and the emulsifier into a stirring pot, heating and stirring for 15 minutes at 80rpm and 65 ℃ to completely dissolve and uniformly disperse all the components to be used as an A phase;
step two: adding the deionized water and the polypeptide whitening and freckle-removing composition into another stirring pot, heating and stirring for 8 minutes at 175rpm and 40 ℃ to completely dissolve and uniformly disperse the components to obtain a phase B;
step three: adding phase A into phase B under stirring, adding thickener and antiseptic into stirring pan, heating and stirring at 50 deg.C at 70rpm to completely dissolve and uniformly disperse each component to obtain phase C;
step four: and (3) under the stirring condition of 40rpm, adding a pH regulator, a chelating agent and essence into the phase C to completely dissolve and uniformly disperse the components, standing for 3 hours, taking samples to be detected to be qualified, filling the samples in an aseptic production line, and warehousing the samples after being detected to be qualified through bacteria, wherein the final product is the product.
Example 3: whitening and freckle removing cream
The implementation provides a whitening and freckle-removing cream containing a polypeptide whitening and freckle-removing composition, which comprises the following components in percentage by mass:
as shown in fig. 1, the preparation method of the whitening and freckle-removing cream comprises the following steps:
the method comprises the following steps: adding the grease and the emulsifier into a stirring pot, heating and stirring for 15 minutes at 80rpm and 70 ℃ to completely dissolve and uniformly disperse all the components to be used as an A phase;
step two: adding the deionized water and the polypeptide whitening and freckle-removing composition into another stirring pot, heating and stirring for 8 minutes at 150rpm and 40 ℃ to completely dissolve and uniformly disperse the components to obtain a phase B;
step three: adding the phase A into the phase B under stirring, adding the thickening agent and the preservative into a stirring pot, heating and stirring at 80rpm and 55 ℃, and completely dissolving and uniformly dispersing the components to obtain a phase C;
step four: and (3) under the stirring condition of 40rpm, adding a pH regulator, a chelating agent and essence into the phase C to completely dissolve and uniformly disperse the components, standing for 5 hours, taking samples to be detected to be qualified, filling the samples in an aseptic production line, and warehousing the samples after being detected to be qualified through bacteria, wherein the final product is the product.
In the above examples 1-3, the polypeptide whitening and spot removing composition comprises, by weight: 20% of polypeptide compound, 10% of acetyl tyrosine, 10% of VC ethyl ether, 10% of arbutin, 5% of tocopherol acetate, 10% of hydroxytyrosol, 15% of nicotinamide and 20% of ethylhexyl methoxycinnamate; wherein the weight ratio of the nonapeptide-1 to the glutathione to the carnosine to the hexapeptide-2 in the polypeptide compound is 2: 3: 3: 2.
in the description herein, references to the description of "one embodiment," "an example," "a specific example" or the like are intended to mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The preferred embodiments of the invention disclosed above are intended to be illustrative only. The preferred embodiments are not intended to be exhaustive or to limit the invention to the precise embodiments disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best utilize the invention. The invention is limited only by the claims and their full scope and equivalents.
Claims (9)
1. The polypeptide whitening and freckle-removing composition is characterized by comprising the following components in percentage by weight: 10-30% of polypeptide compound, 5-15% of acetyl tyrosine, 5-15% of VC ethyl ether, 5-15% of arbutin, 2-10% of tocopheryl acetate, 5-15% of hydroxytyrosol, 10-20% of nicotinamide and 10-30% of ethylhexyl methoxycinnamate.
2. The polypeptide whitening and freckle-removing composition according to claim 1, which comprises the following components in percentage by weight: 20% of polypeptide compound, 10% of acetyl tyrosine, 10% of VC ethyl ether, 10% of arbutin, 5% of tocopherol acetate, 10% of hydroxytyrosol, 15% of nicotinamide and 20% of ethylhexyl methoxycinnamate.
3. The polypeptide whitening and freckle-removing composition of claim 1, wherein the polypeptide complex is a mixture of nonapeptide-1, glutathione, carnosine and hexapeptide-2.
4. A polypeptide whitening and freckle-removing skin care product, which is characterized by comprising the polypeptide whitening and freckle-removing composition as claimed in any one of the claims 1 to 3;
the polypeptide whitening and freckle-removing skin care product comprises, by weight, 10-30% of a humectant, 5-30% of a polypeptide whitening and freckle-removing composition, 10-25% of grease, 0.5-8% of an emulsifier, 0.5-5% of a thickening agent, 0.01-2% of a preservative, 0.1-0.5% of a chelating agent, 0.001-0.1% of an essence, a proper amount of a pH regulator and the balance of deionized water.
5. The polypeptide whitening and freckle-removing skin care product according to claim 4, wherein the humectant is selected from one or more of glycerin, butylene glycol, 1, 3-propylene glycol, hexyldecanol, sorbitol and xylitol;
the oil is selected from one or more of squalane, dimethyl polysiloxane, shea butter oil, sucrose dilaurate, trimethoxyoctylsilane, and phytosterol/octyldodecanol lauroyl glutamate;
the emulsifier is one or more selected from hydrogenated lecithin, polysorbate-20, polysorbate-60, potassium cetyl phosphate, laureth-7, methyl dextran polyether-10, PEG-9 dimethyl silicone oxyethyl polydimethylsiloxane, PPG-1-PEG-9 lauryl glycol ether;
the thickening agent is selected from one or more of xanthan gum, carbomer, polyacrylate cross-linked polymer-6, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer;
the preservative is selected from one or more of phenoxyethanol, butylated hydroxytoluene, benzyl alcohol and sodium benzoate;
the pH regulator is selected from one or more of sodium hydroxide, potassium hydroxide, aminomethyl propanol, sodium citrate and triethanolamine;
the chelating agent is EDTA-2Na and/or EDTA-4 Na;
the essence is peach blossom essence.
6. A method for preparing the polypeptide whitening and freckle-removing skin care product as claimed in claim 5, which is characterized by comprising the following steps:
step1, weighing the grease and the emulsifier according to the formula ratio, adding the grease and the emulsifier into a stirring pot, heating and stirring to completely dissolve and uniformly disperse the components to obtain a phase A;
step2, weighing deionized water and the polypeptide whitening and freckle-removing composition according to the formula ratio, adding the deionized water and the polypeptide whitening and freckle-removing composition into another stirring pot, heating and stirring to completely dissolve and uniformly disperse the components to obtain a phase B;
step3, adding the phase A into the phase B under the stirring condition, then weighing the thickening agent and the preservative according to the formula ratio, adding into a stirring pot, heating and stirring to completely dissolve and uniformly disperse the components to obtain a phase C;
step4, under the condition of stirring, weighing the pH regulator according to the formula ratio, the chelating agent and the essence into the phase C, completely dissolving and uniformly dispersing all the components, standing, entering an aseptic production line for filling after sampling and detecting, and warehousing after bacteria inspection, wherein the final product is the product.
7. The method for preparing a polypeptide whitening and freckle-removing skin care product according to claim 6, wherein in Step1, the heating and stirring temperature is 65-75 ℃, the stirring speed is 80-100rpm, and the stirring time is 10-15 minutes; the temperature of the thermal stirring in the Step2 is 40-50 ℃, the stirring speed is 150-200rpm, and the stirring time is 5-8 minutes; after the thickening agent is added into Step3, stirring at the temperature of 50-55 ℃, at the stirring speed of 50-80rpm for 3-5 minutes;
adding pH regulator, chelating agent and essence into Step4, stopping heating, stirring at 60-100rpm for 3-5 min, standing at room temperature for 3-5 hr to obtain final product with pH of 5-6.
8. The application of the polypeptide whitening and freckle-removing composition as claimed in any one of claims 1-3, wherein the composition is used for preparing skin care products or medical products for external application on human skin.
9. The use according to claim 8, wherein the skin care product is in the form of a serum, lotion or cream.
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